???global.info.a_carregar???
João Morais Cabral completed his Licenciatura in Bioquímica in 1987 at University of Porto and was awarded a Doctorate in Philosophy in 1993 by The University of Edinburgh, Scotland, UK. João Is a Principal Investigator at the IBMC-Instituto de Biologia Molecular e Celular and I3S- Instituto de Investigação e Inovação em Saúde. Works in the area(s) of Natural sciences with emphasis on Biological Sciences and Biochemistry. The general focus of his research are the molecular mechanisms of ion transport, in particular the mechanism of gating in the voltage gated K+ KCNH channels and the mechanisms of regulation of the K+ homeostasis machinery in the bacterial model system B. subtilis.
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
João Morais Cabral

Nomes de citação

  • Morais-Cabral, João

Identificadores de autor

Ciência ID
8618-FEB9-AC28
ORCID iD
0000-0002-4461-9716

Telefones

Telefone
  • 220408800 (Profissional)

Moradas

  • i3S, Rua Alfredo Allen 208, 4200-135, Porto, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
Formação
Grau Classificação
1993
Concluído
 n/a (Doctor of Philosophy)
The University of Edinburgh CALL Scotland, Reino Unido
"Structural studies of two lipocalins" (TESE/DISSERTAÇÃO)
 n/a
1987
Concluído
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
 16??
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/06/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2008/01/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2001/01/01 - 2007/12/31 Assistant and Associate Professor Yale University Department of Molecular Biophysics and Biochemistry, Estados Unidos
1997/03/01 - 2000/12/31 Postdoctoral Scientist Rockefeller University, Estados Unidos
1996/01/01 - 1997/01/31 Postdoctoral scientist University of Leicester, Reino Unido
1994/04/01 - 1995/12/31 Postdoctoral scientist Dana Farber Cancer Institute, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2024/02/07 - 2027/02/06 The cellular organization and molecular function of the K+ machinery in a bacterium
Kmachinery
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/10/01 - 2025/09/30 Using small-molecule inhibitors to explore the unique properties of the bacterial K+ machinery and its potential as an antibacterial target
LCF/PR/HR22/52420004
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação 'la Caixa'
Em curso
2018/08/01 - 2024/07/31 Allosteric modulation of EAG1 gating
2 R01 NS081320
Orientador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 National Institutes of Health
Concluído
2018/07/01 - 2021/06/30 Characterization of the molecular properties of the K+ homeostasis machinery in a bacterium
PTDC/BIA-BQM/29863/2017
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2017/01 - 2020/06 Bacterial K+ transporters are potential antimicrobial targets: mechanisms of transport and regulation
FLAD Life Science 2020
 Fundação Luso-Americana
2012/11/01 - 2016/06/30 Allosteric modulation of EAG1 gating
1 R01 NS081320
Orientador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 National Institutes of Health
Concluído
2013/06/01 - 2015/09/30 Structural and functional studies of a membrane protein, the KtrAB ion transporter
PTDC/BBB-BEP/2017/2012
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/06/01 - 2013/05/31 Functional and structural studies of a Na+-K+ tranporter.
Provided by PTCRIS: 105342
105342
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2003/08 - 2008/07 Structural and functional studies of ion transporters.
5R01GM068585-05
Investigador responsável
Yale University, Estados Unidos
 National Institute of General Medical Sciences
Concluído
2003/08 - 2008/07 Structural and functional studies of ion transporters.
R01GM068585
 National Institute of General Medical Sciences
Produções

Publicações

Artigo em revista
  1. Monteiro, Ricardo; Cereija, Tatiana B.; Pombinho, Rita; Voskuilen, Thijs; Codée, Jeroen D. C.; Sousa, Sandra; Morais-Cabral, João H.; Cabanes, Didier. "Molecular properties of the RmlT wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes". Nature Communications 16 1 (2025): https://doi.org/10.1038/s41467-024-55360-1.
    10.1038/s41467-024-55360-1
  2. Rocha, Rita; Jorge, João M. P.; Teixeira-Duarte, Celso M.; Figueiredo-Costa, Inês R.; Cereija, Tatiana B.; Ferreira-Teixeira, Paula F.; Herzberg, Christina; Stülke, Jörg; Morais-Cabral, João H.. "c-di-AMP determines the hierarchical organization of bacterial RCK proteins". Proceedings of the National Academy of Sciences 121 18 (2024): https://doi.org/10.1073/pnas.2318666121.
    10.1073/pnas.2318666121
  3. Stevens-Sostre, Whitney A.; Flores-Aldama, Lisandra; Bustos, Daniel; Li, Jin; Morais-Cabral, João H.; Delemotte, Lucie; Robertson, Gail A.. "An intracellular hydrophobic nexus critical for hERG1 channel slow deactivation". Biophysical Journal (2024): http://dx.doi.org/10.1016/j.bpj.2024.01.010.
    10.1016/j.bpj.2024.01.010
  4. Celestino, Ricardo; Gama, José B.; Castro-Rodrigues, Artur F.; Barbosa, Daniel J.; Rocha, Helder; d’Amico, Ennio A.; Musacchio, Andrea; et al. "JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport". Journal of Cell Biology 221 8 (2022): http://dx.doi.org/10.1083/jcb.202110057.
    10.1083/jcb.202110057
  5. Sousa, Carla F.; Coimbra, João T.S.; Richter, Robert; Morais-Cabral, João H.; Ramos, Maria J.; Lehr, Claus-Michael; Fernandes, Pedro A.; Gameiro, Paula. "Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model". Biochimica et Biophysica Acta (BBA) - Biomembranes 1864 3 (2022): 183838. http://dx.doi.org/10.1016/j.bbamem.2021.183838.
    10.1016/j.bbamem.2021.183838
  6. Harley, Carol A.; Bernardo-Seisdedos, Ganeko; Stevens-Sostre, Whitney A.; Jones, David K.; Azevedo, Maria M.; Sampaio, Paula; Lorga-Gomes, Marta; et al. "Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating". Proceedings of the National Academy of Sciences 118 44 (2021): e2108796118. http://dx.doi.org/10.1073/pnas.2108796118.
    10.1073/pnas.2108796118
  7. Tatiana B. Cereija; João P. L. Guerra; João M. P. Jorge; João H. Morais-Cabral. "c-di-AMP, a likely master regulator of bacterial K + homeostasis machinery, activates a K + exporter". Proceedings of the National Academy of Sciences 118 14 (2021): https://doi.org/10.1073/pnas.2020653118.
    10.1073/pnas.2020653118
  8. Cereija B. tatiana; Guerra, João P.L.; Jorge, João M.P.; Morais-Cabral, João. "c-di-AMP, a likely master regulator of bacterial K+ homeostasis machinery, activates a K+ exporter". Proceedings of the National Academy of Sciences of the United States of America (2021):
    Aceite para publicação
  9. Fernandes, Andreia S.; Pombinho, António; Teixeira-Duarte, Celso M.; Morais-Cabral, João H.; Harley, Carol A.. "Fluorometric Liposome Screen for Inhibitors of a Physiologically Important Bacterial Ion Channel". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.603700.
    Acesso aberto • 10.3389/fmicb.2021.603700
  10. Kotov, Vadim; Mlynek, Georg; Vesper, Oliver; Pletzer, Marina; Wald, Jiri; Teixeira-Duarte, Celso M.; Celia, Herve; et al. "In-depth interrogation of protein thermal unfolding data with MoltenProt". Protein Science 30 1 (2020): 201-217. http://dx.doi.org/10.1002/pro.3986.
    Publicado • 10.1002/pro.3986
  11. Teixeira-Duarte, Celso M; Fonseca, Fátima; Morais-Cabral, João H. "Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site". eLife 8 (2019): http://dx.doi.org/10.7554/elife.50661.
    Publicado • 10.7554/elife.50661
  12. Celso M Teixeira-Duarte; Fátima Fonseca; João H Morais-Cabral. "Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site". eLife 8 (2019): https://doi.org/10.7554/eLife.50661.
    10.7554/eLife.50661
  13. Robertson, Gail A.; Morais-Cabral, João H.. "hERG Function in Light of Structure". Biophysical Journal (2019): http://dx.doi.org/10.1016/j.bpj.2019.10.010.
    Aceite para publicação • 10.1016/j.bpj.2019.10.010
  14. Rocha, Rita; Teixeira-Duarte, Celso M.; Jorge, João M.P.; Morais-Cabral, João Henrique. "Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis". Journal of Structural Biology 205 3 (2019): 34-43. http://dx.doi.org/10.1016/j.jsb.2019.02.002.
    10.1016/j.jsb.2019.02.002
  15. Pereira, Sara B.; Santos, Marina; Leite, José P.; Flores, Carlos; Eisfeld, Carina; Büttel, Zsófia; Mota, Rita; et al. "The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803". MicrobiologyOpen (2019): e753. http://dx.doi.org/10.1002/mbo3.753.
    10.1002/mbo3.753
  16. Castro-Rodrigues, Artur F.; Zhao, Yaxian; Fonseca, Fátima; Gabant, Guillaume; Cadene, Martine; Robertson, Gail A.; Morais-Cabral, João H.. "The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase". Journal of Molecular Biology 430 24 (2018): 5029-5049. http://dx.doi.org/10.1016/j.jmb.2018.10.015.
    10.1016/j.jmb.2018.10.015
  17. Pinheiro, Jorge; Lisboa, Johnny; Pombinho, Rita; Carvalho, Filipe; Carreaux, Alexis; Brito, Cláudia; Pöntinen, Anna; et al. "MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence". Nucleic Acids Research (2018): http://dx.doi.org/10.1093/nar/gky624.
    10.1093/nar/gky624
  18. Zhao, Yaxian; Goldschen-Ohm, Marcel P.; Morais-Cabral, João H.; Chanda, Baron; Robertson, Gail A.. "The intrinsically liganded cyclic nucleotide–binding homology domain promotes KCNH channel activation". The Journal of General Physiology 149 2 (2017): 249-260. http://dx.doi.org/10.1085/jgp.201611701.
    10.1085/jgp.201611701
  19. Marques-Carvalho, Maria João; Oppermann, Johannes; Muñoz, Eva; Fernandes, Andreia S.; Gabant, Guillaume; Cadene, Martine; Heinemann, Stefan H.; Schönherr, Roland; Morais-Cabral, João Henrique. "Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel". Structure 24 10 (2016): 1742-1754. http://dx.doi.org/10.1016/j.str.2016.07.020.
    10.1016/j.str.2016.07.020
  20. Harley, Carol A.; Starek, Greg; Jones, David K.; Fernandes, Andreia S.; Robertson, Gail A.; Morais-Cabral, João H.. "Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain". Proceedings of the National Academy of Sciences 113 35 (2016): 9916-9921. http://dx.doi.org/10.1073/pnas.1601116113.
    10.1073/pnas.1601116113
  21. Fernandes, Andreia S.; Morais-Cabral, João H.; Harley, Carol A.. "Screening for Non-Pore-Binding Modulators of EAG K+ Channels". Journal of Biomolecular Screening 21 7 (2016): 758-765. http://dx.doi.org/10.1177/1087057116636592.
    10.1177/1087057116636592
  22. Szollosi, Andras; Vieira-Pires, Ricardo S.; Teixeira-Duarte, Celso M.; Rocha, Rita; Morais-Cabral, João H.. "Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter". PLOS Biology 14 1 (2016): e1002356. http://dx.doi.org/10.1371/journal.pbio.1002356.
    10.1371/journal.pbio.1002356
  23. Morais-Cabral, João H.; Robertson, Gail A.. "The Enigmatic Cytoplasmic Regions of KCNH Channels". Journal of Molecular Biology 427 1 (2015): 67-76. http://dx.doi.org/10.1016/j.jmb.2014.08.008.
    10.1016/j.jmb.2014.08.008
  24. Pessoa, João; Fonseca, Fátima; Furini, Simone; Morais-Cabral, João H.. "Determinants of ligand selectivity in a cyclic nucleotide–regulated potassium channel". The Journal of General Physiology 144 1 (2014): 41-54. http://dx.doi.org/10.1085/jgp.201311145.
    10.1085/jgp.201311145
  25. Vieira-Pires, Ricardo S.; Szollosi, Andras; Morais-Cabral, João H.. "The structure of the KtrAB potassium transporter". Nature 496 7445 (2013): 323-328. http://dx.doi.org/10.1038/nature12055.
    10.1038/nature12055
  26. Adaixo, Ricardo; Harley, Carol A.; Castro-Rodrigues, Artur F.; Morais-Cabral, João H.. "Structural Properties of PAS Domains from the KCNH Potassium Channels". PLoS ONE 8 3 (2013): e59265. http://dx.doi.org/10.1371/journal.pone.0059265.
    10.1371/journal.pone.0059265
  27. Marques-Carvalho, Maria J.; Sahoo, Nirakar; Muskett, Frederick W.; Vieira-Pires, Ricardo S.; Gabant, Guillaume; Cadene, Martine; Schönherr, Roland; Morais-Cabral, João H.. "Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel". Journal of Molecular Biology 423 1 (2012): 34-46. http://dx.doi.org/10.1016/j.jmb.2012.06.025.
    10.1016/j.jmb.2012.06.025
  28. Harley, Carol A.; Jesus, Catarina S. H.; Carvalho, Ricardo; Brito, Rui M. M.; Morais-Cabral, João H.. "Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel". PLoS ONE 7 3 (2012): e32654. http://dx.doi.org/10.1371/journal.pone.0032654.
    10.1371/journal.pone.0032654
  29. Marques-Carvalho, Maria João; Morais-Cabral, João Henrique. "Crystallization and preliminary X-ray crystallographic characterization of a cyclic nucleotide-binding homology domain from the mouse EAG potassium channel". Acta Crystallographica Section F Structural Biology and Crystallization Communications 68 3 (2012): 337-339. http://dx.doi.org/10.1107/s1744309112004216.
    10.1107/s1744309112004216
  30. Marques-Carvalho, M.J.; Morais-Cabral, J.H.. "Crystallization and preliminary X-ray crystallographic characterization of a cyclic nucleotide-binding homology domain from the mouse EAG potassium channel". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 68 3 (2012): 337-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858952456&partnerID=MN8TOARS.
    10.1107/S1744309112004216
  31. Mari, S. A.; Pessoa, J.; Altieri, S.; Hensen, U.; Thomas, L.; Morais-Cabral, J. H.; Muller, D. J.. "Gating of the MlotiK1 potassium channel involves large rearrangements of the cyclic nucleotide-binding domains". Proceedings of the National Academy of Sciences 108 51 (2011): 20802-20807. http://dx.doi.org/10.1073/pnas.1111149108.
    10.1073/pnas.1111149108
  32. Vieira-Pires, Ricardo Simão; Morais-Cabral, João Henrique. "3(10) helices in channels and other membrane proteins". The Journal of General Physiology 136 6 (2010): 585-592. http://dx.doi.org/10.1085/jgp.201010508.
    10.1085/jgp.201010508
  33. Adaixo, Ricardo; Morais-Cabral, João Henrique. "Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels". Acta Crystallographica Section F Structural Biology and Crystallization Communications 66 9 (2010): 1056-1059. http://dx.doi.org/10.1107/s1744309110027880.
    10.1107/s1744309110027880
  34. Adaixo, R.; Morais-Cabral, J.H.. "Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66 9 (2010): 1056-1059. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956518140&partnerID=MN8TOARS.
    10.1107/S1744309110027880
  35. Clayton, Gina M.; Aller, Steve G.; Wang, Jimin; Unger, Vinzenz; Morais-Cabral, João H.. "Combining electron crystallography and X-ray crystallography to study the MlotiK1 cyclic nucleotide-regulated potassium channel". Journal of Structural Biology 167 3 (2009): 220-226. http://dx.doi.org/10.1016/j.jsb.2009.06.012.
    10.1016/j.jsb.2009.06.012
  36. Altieri, Stephen L.; Clayton, Gina M.; Silverman, William R.; Olivares, Adrian O.; De La Cruz, Enrique M.; Thomas, Lise R.; Morais-Cabral, João H.. "Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain". Journal of Molecular Biology 381 3 (2008): 655-669. http://dx.doi.org/10.1016/j.jmb.2008.06.011.
    10.1016/j.jmb.2008.06.011
  37. Clayton, G. M.; Altieri, S.; Heginbotham, L.; Unger, V. M.; Morais-Cabral, J. H.. "Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel". Proceedings of the National Academy of Sciences 105 5 (2008): 1511-1515. http://dx.doi.org/10.1073/pnas.0711533105.
    10.1073/pnas.0711533105
  38. Albright, Ronald A.; Joh, Kyu; Morais-Cabral, João H.. "Probing the Structure of the Dimeric KtrB Membrane Protein". Journal of Biological Chemistry 282 48 (2007): 35046-35055. http://dx.doi.org/10.1074/jbc.m704260200.
    10.1074/jbc.m704260200
  39. Albright, R.A.; Joh, K.; Morais-Cabral, J.H.. "Probing the structure of the dimeric KtrB membrane protein". Journal of Biological Chemistry 282 48 (2007): 35046-35055. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849015754&partnerID=MN8TOARS.
    10.1074/jbc.M704260200
  40. Albright, Ronald A.; Ibar, José-Luís Vazquez; Kim, Chae Un; Gruner, Sol M.; Morais-Cabral, João Henrique. "The RCK Domain of the KtrAB K+ Transporter: Multiple Conformations of an Octameric Ring". Cell 126 6 (2006): 1147-1159. http://dx.doi.org/10.1016/j.cell.2006.08.028.
    10.1016/j.cell.2006.08.028
  41. Clayton, Gina M.; Silverman, William R.; Heginbotham, Lise; Morais-Cabral, João H.. "Structural Basis of Ligand Activation in a Cyclic Nucleotide Regulated Potassium Channel". Cell 119 5 (2004): 615-627. http://dx.doi.org/10.1016/j.cell.2004.10.030.
    10.1016/j.cell.2004.10.030
  42. Zhou, Yufeng; Morais-Cabral, João H.; Kaufman, Amelia; MacKinnon, Roderick. "Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0¿Å resolution". Nature 414 6859 (2001): 43-48. http://dx.doi.org/10.1038/35102009.
    10.1038/35102009
  43. Morais-Cabral, João H.; Zhou, Yufeng; MacKinnon, Roderick. "Energetic optimization of ion conduction rate by the K+ selectivity filter". Nature 414 6859 (2001): 37-42. http://dx.doi.org/10.1038/35102000.
    10.1038/35102000
  44. Zhou, Ming; Morais-Cabral, João H.; Mann, Sabine; MacKinnon, Roderick. "Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors". Nature 411 6838 (2001): 657-661. http://dx.doi.org/10.1038/35079500.
    10.1038/35079500
  45. Cabral, João H.Morais; Lee, Alice; Cohen, Steven L; Chait, Brian T; Li, Min; Mackinnon, Roderick. "Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus". Cell 95 5 (1998): 649-655. http://dx.doi.org/10.1016/s0092-8674(00)81635-9.
    10.1016/s0092-8674(00)81635-9
  46. Doyle, D. A.. "The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity". Science 280 5360 (1998): 69-77. http://dx.doi.org/10.1126/science.280.5360.69.
    10.1126/science.280.5360.69
  47. Morals Cabral, J.H.; Lee, A.; Cohen, S.L.; Chait, B.T.; Li, M.; Mackinnon, R.. "Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain". Cell 95 5 (1998): 649-655. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032567106&partnerID=MN8TOARS.
  48. Marfatia, Shirin M.; Morais-Cabral, Joao H.; Kim, Anthony C.; Byron, Olwyn; Chishti, Athar H.. "The PDZ Domain of Human Erythrocyte p55 Mediates Its Binding to the Cytoplasmic Carboxyl Terminus of Glycophorin C". Journal of Biological Chemistry 272 39 (1997): 24191-24197. http://dx.doi.org/10.1074/jbc.272.39.24191.
    10.1074/jbc.272.39.24191
  49. Cabral, Joo H. Morais; Jackson, Andrew P.; Smith, Clare V.; Shikotra, Nita; Maxwell, Anthony; Liddington, Robert C.. "Crystal structure of the breakage–reunion domain of DNA gyrase". Nature 388 6645 (1997): 903-906. http://dx.doi.org/10.1038/42294.
    10.1038/42294
  50. Brownlow, Sharon; Cabral, João H Morais; Cooper, Ron; Flower, Darren R; Yewdall, Stephen J; Polikarpov, Igor; North, Anthony CT; Sawyer, Lindsay. "Bovine ß-lactoglobulin at 1.8 Å resolution —  still an enigmatic lipocalin". Structure 5 4 (1997): 481-495. http://dx.doi.org/10.1016/s0969-2126(97)00205-0.
    10.1016/s0969-2126(97)00205-0
  51. Marfatia, S. M.; Morais-Cabral, Joao H.; Lin, L; Hough C; Bryant PJ; Stolz L; Chishti AH. "Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton". The Journal of Cell Biology 135 3 (1996): 753-766. http://dx.doi.org/10.1083/jcb.135.3.753.
    10.1083/jcb.135.3.753
  52. Morais-Cabral, J. H.; Petosa,C.; Sutcliffe MJ; Raza S; Byron O; Poy F; Marfatia SM; Chishti AH; Liddington, Robert C.. "Crystal structure of a PDZ domain". Nature 382 6592 (1996): 649-652.
    Publicado
  53. Morais Cabral, J.H.; Petosa, C.; Sutcliffe, M.J.; Raza, S.; Byron, O.; Poy, F.; Marfatia, S.M.; Chishti, A.H.; Liddington, R.C.. "Crystal structure of a PDZ domai". Nature 382 6592 (1996): 649-652. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001643541&partnerID=MN8TOARS.
    10.1038/382649a0
  54. Morais Cabral, João H.; Atkins, Gordon L.; Sánchez, Luis M.; López-Boado, Yolanda S.; López-Otin, Carlos; Sawyer, Lindsay. "Arachidonic acid binds to apolipoprotein D: implications for the protein's function". FEBS Letters 366 1 (1995): 53-56. http://dx.doi.org/10.1016/0014-5793(95)00484-q.
    10.1016/0014-5793(95)00484-q
  55. Morais Cabral, J.H.; Atkins, G.L.; Sánchez, L.M.; López-Boado, Y.S.; López-Otin, C.; Sawyer, L.. "Arachidonic acid binds to apolipoprotein D: implications for the protein's function". FEBS Letters 366 1 (1995): 53-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029057534&partnerID=MN8TOARS.
    10.1016/0014-5793(95)00484-Q
Pré-impressão
  1. Monteiro, Ricardo; Cereija, Tatiana B.; Pombinho, Rita; Sousa, Sandra; Morais-Cabral, João H.; Cabanes, Didier. "Molecular properties of RmlT, a wall teichoic acid rhamnosyltransferase that modulatesListeria monocytogenesvirulence and antibiotic resistance". 2024. http://dx.doi.org/10.1101/2024.01.23.574818.
    10.1101/2024.01.23.574818
  2. Rocha, Rita; Jorge, João M. P.; Texeira-Duarte, Celso M.; Figueiredo-Costa, Inês R.; Herzberg, Christina; Stülke, Jörg; Morais-Cabral, João H.. "c-di-AMP determines the hierarchical organization of bacterial RCK proteins". 2023. http://dx.doi.org/10.1101/2023.04.24.538052.
    10.1101/2023.04.24.538052
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/10/01 Special Seminar Special Seminar
Department of Neurosciences, Univ. of Wisconsin-Madison (Estados Unidos)
2023/10/01 Departmental seminar Departmental seminar
Dep. of Bioch. and Mol. Biology, University of Chicago (Estados Unidos)
2023/10/01 Special Seminar Special Seminar
Rockefeller Univiversity (Estados Unidos)
2023/07/01 Advanced Workshop on Ion Channels Advanced Workshop on Ion Channels
Institutua Biofisika, University of Basque Country (Espanha)
2023/06/01 Biophysics Festival 2023 Portuguese Young Biophysicists
Portuguese Biophysical Society (Portugal)
2023/04/14 Structural Biology Symposium Structural Biology Symposium
Sciences Academy of Lisbon (Portugal)
2019/12/16 Institute of Biomedical Technologies, Universidad de La Laguna, Spain
2019/10/02 7th SIPF International Workshop 7th SIPF International Workshop
(Sestri Levante, Genova, Itália)
2019/02/01 Dept. of Bioch. and Mol. Biology, Baylor College of Medicine, Houston, USA, February 2019 Dept. of Bioch. and Mol. Biology, Baylor College of Medicine, Houston, USA
(Houston, Estados Unidos)
2017/09/01 FEBS congress 2017, Symposium speaker, Jerusalem, Israel, September 2017 FEBS congress 2017
(Jerusalém, Israel)
2015/11/01 11th Symposium “Trends in Structural Biology”, Univ. of Zurich, Zurich, Switzerland, August 2015 11th Symposium “Trends in Structural Biology”
2015/10/01 5th RECI meeting, Meeting of the Spanish Network on Ion Channels, Barcelona, October 2015 5th RECI meeting, Meeting of the Spanish Network on Ion Channels
2015/06/01 Membrane Transport Colloquium (inter-departmental seminar series), Goethe Univ., Frankfurt, Germany, June 2015
Membrane Transport Colloquium (inter-departmental seminar series)
2014/07/01 European Bioenergetics Conference, Plenary Lecture speaker, Lisboa, Portugal July 2014 European Bioenergetics Conference
2014/06/01 Colloque du Patch-Club de Montpellier, Montpellier, France, June 2014 Colloque du Patch-Club de Montpellier
2014/05/01 Conferences for the International Year of Crystallography 2014, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, May 2014 Conferences for the International Year of Crystallography 2014
2014/05/01 Instituto Gulbenkian de Ciência, Oeiras, Portugal, May 2014 Instituto Gulbenkian de Ciência
2014/03/01 Gordon Research Conf., Ligand Recognition and Molecular Gating, Ventura, USA, March 2014 Gordon Research Conf., Ligand Recognition and Molecular Gating
2013/08/01 Alfred Benzon symposium- Membrane proteins: structure, function and dynamics, Copenhagen, Denmark, August 2013 Alfred Benzon symposium- Membrane proteins: structure, function and dynamics
2013/07/01 IUPS 2013(International Union of Phys. Soc.), Symposium speaker, Birmingham, July 2013 IUPS 2013(International Union of Phys. Soc.)
2013/07/01 9th European Biophysics Congress, Symposium speaker, Lisbon, Portugal, July 2013 9th European Biophysics Congress
2012/11/01 ITQB, Inst. Tecnol. Quím. e Biol., Lisbon, Portugal, November 2012
2012/10/01 Center for Molecular Medicine, Friedrich Schiller University of Jena, October 2012
2012/02/01 56th Biophysical Society meeting, San Diego, Symposium speaker, February 2012 56th Biophysical Society meeting
2012/02/01 Dept of Physiology and Cellular Biophysics, Columbia University, USA, February 2012
2011/11/01 Dept. of Biochemistry, University of Leicester, UK, November 2011
2011/02/01 RECI-3, Meeting of the Spanish Network on Ion Channels, Tenerife, Spain, February 2011 RECI-3, Meeting of the Spanish Network on Ion Channels
2010/05/01 Gordon Research Conf. Ligand Recognition and Molecular Gating, Il Ciocco, Italy, May 2010 Gordon Research Conf. Ligand Recognition and Molecular Gating
2010/02/01 Workshop “Channelopathies: from bench to bedside”, Gavá (Barcelona), Spain, February 2010 Workshop “Channelopathies: from bench to bedside”
2009/10/01 University of Dundee, Division of Molecular MicroBiology, Dundee, UK, October 2009
2009/08/01 21st IUBMB International Congress and 12th FAOBMB Congress of Biochemistry and -Molecular Biology, Symposium speaker, Shanghai, China, August 2009 21st IUBMB International Congress and 12th FAOBMB Congress of Biochemistry and -Molecular Biology
2009/01/01 Mini-symposium on Frontiers of membrane protein structure, Partnership for Structural Biology, Grenoble, January 2009 Mini-symposium on Frontiers of membrane protein structure, Partnership for Structural Biology
2008/09/01 Autumn meeting of the Society for General Microbiology, Dublin, Symposium speaker, September 2008 Autumn meeting of the Society for General Microbiology
2008/06/01 Young Investigator Program 2008 meeting, EMBL, Heidelberg, Germany, June 2008
2008/05/01 Sinal 2008 (2nd National meeting on Signal transduction), IBMC, Porto, Portugal, May 2008
2008/04/01 MPI of Biophysics, Max Planck Institute of Biophysics, Frankfurt, Germany, April 2008
2008/02/01 IPATIMUP, Inst. de Patologia e Imunol. Molec. da Univ. do Porto, Porto, Portugal, March 2008
2008/02/01 ITQB, Inst. Tecnol. Quím. e Biol., Lisbon, Portugal, February 2008
2008/02/01 52nd Biophysical Society Meeting, Long Beach, Platform speaker, February 2008
2007/04/01 Institute for Biophysical Dynamics, University of Chicago, April 2007
2007/03/01 Membrane Protein Interest Group, National Institutes of Health, March 2007
2006/06/01 Biochemistry Department, University of Zurich, Switzerland, June 2006
2006/06/01 Gordon Research Conf. Ligand Recognition and Molecular Gating, Il Ciocco, Italy, June 2006
2006/04/01 Structural Biology Program at Memorial Sloan-Kettering Cancer Center, New York, April 2006
2004/11/01 Symposium on Structural Biology, IBMC, University of Porto, Porto, Portugal, November 2004
2004/10/01 3rd Portuguese and Spanish Biophysics Meeting, Lisbon, Portugal, October 2004
2004/09/01 Dept. of Biochemistry and Molecular Biophysics, Columbia University, New York, September 2004
2004/07/01 Gordon Conference Ion Channels, Tilton College, July 2004
2002/12/01 XIII Portuguese Biochemistry Meeting, Lisbon, Portugal December 2002
2002/05/01 Olga G. Nalbandov Symposium, University of Illinois, Urbana-Champaign, May 2002
2002/04/01 Dept. Physiology and Biophysics, University Texas Medical Branch at Galveston, April 2002

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/02/01 - Atual Isabel Matas - Postdoctoral Scientist
Orientador
2020/03/02 - Atual Katharina Weinhäupl - Postdoctoral Scientist
Orientador
2018/05/01 - Atual Tatiana Cereija - Postdoctoral Scientist
Orientador
2008/01/01 - Atual Carol Ann Harley - Research Scientist
Orientador
2015/01/01 - 2023/01/01 Andreia Fernandes - Research Scientist
Orientador
2016/02/01 - 2021/06/01 Rita Rocha - Postdoctoral Scientist
Orientador
2016/01/01 - 2021/06/01 Celso Duarte - PhD student
Orientador
 Thesis submitted (Doutoramento)
2009/04/01 - 2021/01/01 Omar Santín - Postdoctoral Scientist
Orientador
2009/03/01 - 2020/08/01 João Jorge - Former postdoctoral scientist in the lab
Orientador
2012/12/01 - 2015/12/01 Maria João Marques de Carvalho - Former PhD student in the lab
Orientador
 Thesis: Structural and Biochemical characterization of the interaction of calmodulin with the EAG1 potassium channel cytoplasmic regions (Doutoramento)
2011/12/01 - 2014/12/01 João Pedro Abreu Pessoa - Former PhD student in the lab
Orientador
 Thesis: Cyclic nucleotide regulation in a potassium channel (Doutoramento)
2001/03/01 - 2007/01/01 Aristidis Sachpatzidis - Former postdoctoral scientist in the lab
Orientador
2001/05/01 - 2006/04/01 Jose-Luis Vazquez Ibar - Former postdoctoral scientist in the lab
Orientador
2001/02/01 - 2006/01/01 Gina Clayton - Former postdoctoral scientist in the lab
Orientador
2001/01/01 - 2006/01/01 Ronald Albright - Former postdoctoral scientist in the lab
Orientador
2001/06/01 - 2005/02/02 Sean Zhou - Former postdoctoral scientist in the lab
Orientador