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Maria Sousa Rebelo completed her PhD in Biomedical Sciences in 2017/04 at the Faculty of Medicine of the University of Lisbon. She did her Master in Applied Microbiology in 2010/10 at the Faculty of Sciences of the University of Lisbon and has a Degree in Microbiology in 2009/06 by the Faculty of Medicine of the University of Lisbon. She did her first post-doc QIMR Berghofer Medical Research Institute, Australia, where she joined Dr McCarthy group. In May 2020, she started her second post-doc at iMM, Portugal, at Prof Bernardes group. She published 24 articles in peer-reviewed journals and has been invited to present her work in 5 of specialized conferences. She organized 4 events, received 8 awards and / or honors. In 2018, she was awarded with a Seed Grant from the Australian Centre of Research Excellence in Malaria Elimination. More recently, in 2023, she was granted with the prestigious "la Caixa" Junior Leader Fellowship and an FCT RESTART grant. She operates in the area of Medical and Health Sciences with an emphasis on Infectious Diseases. In its Ciência Vitae curriculum, the most frequent terms in the context of scientific and technological production are: malaria; antimalarial drugs; flow cytometry; microbiology; ELISA; diagnostic techniques; drug resistance; microbiology; parasitology; hemozoin; malarial pigment.
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Identificação

Identificação pessoal

Nome completo
Maria Sousa Rebelo
Data de nascimento
1986/03/13
Género
Feminino

Nomes de citação

  • Rebelo, Maria

Identificadores de autor

Ciência ID
8B1D-62C4-0050
ORCID iD
0000-0003-2715-7182

Endereços de correio eletrónico

  • mariarebelo@medicina.ulisboa.pt (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde - Parasitologia
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1)
Formação
Grau Classificação
2020/05/07 - 2021
Em curso
 Post-doctoral Research Scientist (Pós-doutoramento)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2017/10/03 - 2020/03/31
Concluído
 Research Officer (level 3) (Postgraduate Certificate)
QIMR Berghofer Medical Research Institute, Austrália
2013/01 - 2017/05
Concluído
 Biomedical Sciences (Doutoramento)
Especialização em Microbiology and Parasitology
Universidade de Lisboa Faculdade de Medicina, Portugal
"DEVELOPMENT OF AN INNOVATIVE REAL-TIME ASSAY FOR ANTIMALARIAL SENSITIVITY TESTING AND INTERROGATION OF NOVEL COMPOUNDS" (TESE/DISSERTAÇÃO)
2009/09 - 2010/10
Concluído
 Microbiologia Aplicada (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
 18
2005/09 - 2009/06
Concluído
 Microbiologia (Licenciatura)
Especialização em Microbiologia
Universidade de Lisboa Faculdade de Medicina, Portugal
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/05/07 - Atual Pós-doutorado (Investigação) Instituto de Medicina Molecular João Lobo Antunes, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2017/10 - 2020/05 Pós-doutorado (Investigação) QIMR Berghofer Medical Research Institute, Austrália
QIMR Berghofer Medical Research Institute, Austrália
Projetos

Bolsa

Designação Financiadores
2018/01 - 2020/06 Development of a screening tool to identify antimalarial drugs effective against artemisinin-resistant malaria
N/A
Investigador responsável
QIMR Berghofer Medical Research Institute, Austrália

The Australian Centre of Research Excellence in Malaria Elimination (ACREME), Austrália
The Australian Centre of Research Excellence in Malaria Elimination (ACREME)
2013/01 - 2017/01 Development of an innovative real-time assay for antimalarial sensitivity testing and interrogation of novel compounds
SFRH/BD/84530/201
 Fundação para a Ciência e a Tecnologia
2010/02 - 2013/01 Respiratory tract infections & malaria: a new case of mutual interactions?
grant.Provided by PTCRIS: 108578
 Fundação para a Ciência e a Tecnologia

Outro

Designação Financiadores
2020/12 - Atual Pre-clinical investigation of a hACE2 decoy against SARS-CoV-2 infection in K18hACE2 mice
N/a
Investigador Pós-doutorado
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Neoleukin Therapheutics, Inc
Em curso
2017/10 - 2020/05 Investigation of malaria parasite viability after drug treatment in volunteer infection studies
N/A
Investigador Pós-doutorado
QIMR Berghofer Medical Research Institute, Austrália
Em curso
Produções

Publicações

Artigo em revista
  1. Sigitas Mikutis; Maria Rebelo; Eliza Yankova; Muxin Gu; Cong Tang; Ana R. Coelho; Mo Yang; et al. "Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules". ACS Central Science (2023): http://dx.doi.org/10.1021/acscentsci.3c00015.
    10.1021/acscentsci.3c00015
  2. Tang C; Ana R Coelho; Rebelo M; Kiely-Collins H; Carvalho T; Gonçalo J. L. Bernardes. "A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species.". ACS central science (2023): https://europepmc.org/articles/PMC9881195.
    10.1021/acscentsci.2c01243
  3. Radohery GFR; Walz A; Gumpp C; Mohammed H. Cherkaoui-Rbati; Gobeau N; Gower J; Davenport MP; et al. "Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment.". Antimicrobial agents and chemotherapy (2022): https://europepmc.org/articles/PMC9295577.
    10.1128/aac.00114-22
  4. Radohery, G.F.R.; Gower, J.; Barber, B.E.; Kansagra, K.; Möhrle, J.J.; Davenport, M.P.; McCarthy, J.S.; Khoury, D.S.; Rebelo, M.. "Effect of novel antimalarial ZY-19489 on Plasmodium falciparum viability in a volunteer infection study". The Lancet Infectious Diseases 22 6 (2022): 760-761. http://www.scopus.com/inward/record.url?eid=2-s2.0-85130526886&partnerID=MN8TOARS.
    10.1016/S1473-3099(22)00294-8
  5. Stephen Woolley; Melissa Fernandez; Rebelo, Maria (8B1D-62C4-0050); Stacey A. Llewellyn; Louise Marquart; Fiona H. Amante; Helen E. Jennings; et al. "Development and evaluation of a new Plasmodium falciparum 3D7 blood stage malaria cell bank for use in malaria volunteer infection studies.". Malaria journal (2021): https://doi.org/10.1186/s12936-021-03627-z.
    10.1186/s12936-021-03627-z
  6. Odedra, Anand; Mudie, Kari; Kennedy, Glen; Watts, Rebecca E.; Rossignol, Emilie; Mitchell, Hayley; Gower, Jeremy; et al. "Safety and feasibility of apheresis to harvest and concentrate parasites from subjects with induced blood stage Plasmodium vivax infection". Malaria Journal 20 1 (2021): http://dx.doi.org/10.1186/s12936-021-03581-w.
    Publicado • 10.1186/s12936-021-03581-w
  7. Maria Rebelo; James S McCarthy; David S Khoury. "Reply to White and Watson". The Journal of Infectious Diseases (2020): https://doi.org/10.1093/infdis/jiaa791.
    10.1093/infdis/jiaa791
  8. Rebelo, Maria; Pawliw, Rebecca; Gower, Jeremy; Webb, Lachlan; Mitchell, Hayley; Pava, Zuleima; Watts, Rebecca E; et al. "Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans". The Journal of Infectious Diseases (2020): http://dx.doi.org/10.1093/infdis/jiaa678.
    Publicado • 10.1093/infdis/jiaa678
  9. Watts, Rebecca E.; Odedra, Anand; Marquart, Louise; Webb, Lachlan; Abd-Rahman, Azrin N.; Cascales, Laura; Chalon, Stephan; et al. "Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia". PLOS Medicine 17 8 (2020): e1003203. http://dx.doi.org/10.1371/journal.pmed.1003203.
    Publicado • 10.1371/journal.pmed.1003203
  10. Khoury, David S.; Zaloumis, Sophie G.; Grigg, Matthew J.; Haque, Ashraful; Davenport, Miles P.. "Malaria Parasite Clearance: What Are We Really Measuring?". Trends in Parasitology (2020): http://dx.doi.org/10.1016/j.pt.2020.02.005.
    Publicado • 10.1016/j.pt.2020.02.005
  11. Orbán, Ágnes; Rebelo, Maria; Molnár, Petra; Albuquerque, Inês S.; Butykai, Adam; Kézsmárki, István. "Efficient monitoring of the blood-stage infection in a malaria rodent model by the rotating-crystal magneto-optical method". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep23218.
    10.1038/srep23218
  12. Rebelo, Maria; Hänscheid, Thomas. "Flow Cytometry for Antimalarial Drug Testing: More than Meets the Eye". Journal of Clinical Microbiology 54 3 (2016): 817-817. http://dx.doi.org/10.1128/jcm.03017-15.
    10.1128/jcm.03017-15
  13. Rebelo, Maria; Grenho, Rita; Orban, Agnes; Hänscheid, Thomas. "Transdermal Diagnosis of Malaria Using Vapor Nanobubbles". Emerging Infectious Diseases 22 2 (2016): 343-344. http://dx.doi.org/10.3201/eid2202.151203.
    10.3201/eid2202.151203
  14. Rebelo, Maria; Tempera, Carolina; Fernandes, José F; Grobusch, Martin P; Hänscheid, Thomas. "Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay". Malaria Journal 14 1 (2015): http://dx.doi.org/10.1186/s12936-015-0657-8.
    10.1186/s12936-015-0657-8
  15. Rebelo, Maria; Tempera, Carolina; Bispo, Claudia; Andrade, Claudia; Gardner, Rui; Shapiro, Howard M.; Hänscheid, Thomas. "Light depolarization measurements in malaria: A new job for an old friend". Cytometry Part A 87 5 (2015): 437-445. http://dx.doi.org/10.1002/cyto.a.22659.
    10.1002/cyto.a.22659
  16. Hänscheid, Thomas; Rebelo, Maria; Grobusch, Martin P. "Point-of-care tests: where is the point?". The Lancet Infectious Diseases 14 10 (2014): 922. http://dx.doi.org/10.1016/s1473-3099(14)70914-4.
    10.1016/s1473-3099(14)70914-4
  17. Agnes Orbán; Ádám Butykai; András Molnár; Zsófia Pröhle; Gergö Fülöp; Tivadar Zelles; Wasan Forsyth; et al. "Evaluation of a novel magneto-optical method for the detection of malaria parasites.". PloS One (2014): http://europepmc.org/abstract/med/24824542.
    10.1371/journal.pone.0096981
  18. Kirsten K Hanson; Ana S Ressurreição; Kathrin Buchholz; Miguel Prudêncio; Jonathan D Herman-Ornelas; Rebelo, Maria; Wandy L Beatty; et al. "Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.". Proceedings of the National Academy of Sciences of the United States of America (2013): http://europepmc.org/abstract/med/23836641.
    10.1073/pnas.1306097110
  19. Shapiro, Howard M.; Apte, Simon H.; Chojnowski, Grace M.; Hänscheid, Thomas; Rebelo, Maria; Grimberg, Brian T.. "Cytometry in Malaria-A Practical Replacement for Microscopy?". Current Protocols in Cytometry 65 1 (2013): 11.20.1-11.20.23. http://dx.doi.org/10.1002/0471142956.cy1120s65.
    Publicado • 10.1002/0471142956.cy1120s65
  20. Rebelo, Maria; Claudia Sousa; Howard M Shapiro; Maria M Mota; Martin P Grobusch; Thomas Hänscheid. "A novel flow cytometric hemozoin detection assay for real-time sensitivity testing of Plasmodium falciparum.". PloS one (2013): http://europepmc.org/abstract/med/23637865.
    10.1371/journal.pone.0061606
  21. Rebelo, Maria; Howard M Shapiro; Teresa Amaral; José Melo-Cristino; Thomas Hänscheid. "Haemozoin detection in infected erythrocytes for Plasmodium falciparum malaria diagnosis-prospects and limitations.". Acta tropica (2012): http://europepmc.org/abstract/med/22465900.
    10.1016/j.actatropica.2012.03.005
  22. Rosangela Frita; Rebelo, Maria; Ana Pamplona; Ana M Vigario; Maria M Mota; Martin P Grobusch; Thomas Hänscheid. "Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing.". Malaria journal (2011): http://europepmc.org/abstract/med/21453521.
    10.1186/1475-2875-10-74
Pré-impressão
  1. Molly Parkyn Schneider; Oliver Looker; Maria Rebelo; David K. Khoury; Matthew W.A. Dixon; Claude Oeuvray; Brendan S. Crabb; James McCarthy; Paul R. Gilson. "The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts". 2023. http://dx.doi.org/10.1101/2023.04.24.538013.
    10.1101/2023.04.24.538013

Outros

Outra produção
  1. Plasmodium falciparum artemisinin-resistant K13 mutations confer a sexual-stage transmission advantage that can be overcome with atovaquone-proguanil. 2020. Zuleima Pava; Sachel Mok; Katharine A. Collins; Maria Rebelo; Rebecca E. Watts; Gregory J. Robinson; Claire Y.T. Wang; et al. https://doi.org/10.1101/2020.10.26.20214619.
    10.1101/2020.10.26.20214619
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/09/28 Antiviral NL-CVX1 efficiently blocks infection by SARS-CoV-2 viral variants of concern (VOC) IDWeek 2021
Infectious Diseases Society of America (IDSA) (San Diego, Estados Unidos)
2020/02/27 Viability of artemisinin-sensitive and artemisinin-resistant P. falciparum parasites after drug treatment in volunteer infection studies Molecular Approaches to Malaria Conference
(Lorne, Austrália)
2019/10/29 Viability of artemisinin-sensitive and artemisinin-resistant P. falciparum parasites after artesunate treatment in a volunteer infection study. Malaria in Melbourne
(Melbourne, Austrália)
2019/06/29 Drug Testing in Volunteer Infection Studies: The Importance of Blood-Stage Parasite Viability in the Investigation of Antimalarial Drug Efficacy Malaria Gordon Research Seminar
(Les Diablerets, Suiça)
2018/10 A randomized controlled trial comparing parasite clearance profiles after single dose artesunate among subjects experimentally infected with artemisinin-resistant or artemisinin-sensitive Plasmodium falciparum parasites ASTMH 67th Annual Meeting
America Society for Tropical Medicine and Hygiene (New Orleans, Estados Unidos)
2016/04/09 Deteção de luz depolarizada por citometria de fluxo e o seu papel no estudo da Malária. 13o Congresso da Análises Clínicas e Saúde Pública
(Coimbra, Portugal)
2015/06 Flow Cytometric Detection of Light Depolarization and Malaria Research XIV Congresso Sociedade Ibérica de Citometria
Sociedade Ibérica de Citometria (Las Palmas, Espanha)
2014/05/20 Flow Cytometric Detection of Light Depolarization: A Novel Assay to Detect Antimalarial Drug Effects. CYTO2014 - XXIX Congress of the International Society for Advancement of Cytometry
International Society for Advancement of Cytometry (Fort Lauderdale, Estados Unidos)
2013/05 A novel flow cytometric approach to assess antimalarial drug resistance XIII Congresso Sociedade Ibérica de Citometria
Sociedade Ibérica de Citometria (Aveiro, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/02 - 2020/12 Investigating the Role of OPG, TRAIL and Fas in Plasmodium falciparum Infection
Coorientador
 Biomedical Sciences (Iniciação científica)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/08 - 2019/09 Trainer of “Malaria Flow cytometry Practical workshop” in the Flow Cytometry Methods Course hosted in QIMR Berghofer in Brisbane, Australia. (2019/08/25 - 2019/08/30)
Oficina (workshop) (Outra)
 QIMR Berghofer Medical Research Institute, Austrália
2019/05 - 2019/08 Organiser of the "Clinical Tropical Medicine" 2-day Malaria Workshop, hosted at QIMR Berghofer Research Institute in Brisbane, Australia. (2019/08/07 - 2019/08/08)
Oficina (workshop) (Presidente da Comissão Organizadora)
 QIMR Berghofer Medical Research Institute, Austrália
2013/07 - 2013/07 Trainer of ELISA Workshop from CANTAM (Central Africa Network on Tuberculosis, HIV/AIDS and Malaria) at Centre de Recherches Medicales de Lambaréné, Albert Schweitzer Hospital, Gabon. (2013/07 - 2013/07)
Oficina (workshop) (Membro da Comissão Organizadora)
 Centre de Recherches Médicales de Lambaréné, Gabão

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2020/05 - Atual Pro bono consultant at Medicines for Malaria Venture Medicines for Malaria Venture, Suiça

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2015/05 - 2015/05 Lecturer at two practical lessons on Malaria Diagnosis and Antimalarial Drug Resistance Testing in the Master of Microbiology from Instituto Superior Técnico de Lisboa. Microbiologia (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/07 - 2014/07 Lecturer in Clinical Microbiology and Tropical Diseases in the Programa de Pós- Graduação Ciência para o Desenvolvimento (PGCD) from Instituto Gulbenkian de Ciência (Pós-Graduação) Instituto Gulbenkian de Ciência, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2020/01/05 - 2020/01/05 Telejornal de Domingo da RTP Madeira Estudar malaria em voluntários na Australia
2015 - 2015 Madeira à vista Experiencia como investigadora de malaria em Portugal e no Gabao

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020/01 - 2020/09 Member of the BLiSS*Brisbane 2020 organising committee, Australia.
Membro
2015/05 - 2016/05 Representative of the PhD Students Commission at Institute de Medicina Molecular, Portugal.
Presidente / Vice-presidente
 Instituto de Medicina Molecular João Lobo Antunes, Portugal

Tutoria

Tópico Nome do aluno
2018/04 - Atual Understanding parasite growth dynamics using in vivo models of blood-stage malaria Lianne Lansink
Distinções

Prémio

2023 "la Caixa" Junior Leader Fellowship
"la Caixa" Foundation, Espanha
2020 Best Talk at ACORN Summer School and Workshop
Royal Society of Chemistry, Reino Unido
2019 Best oral presentation at 2019 Malaria in Melbourne
2014 2014 Exceptional Student Award, awarded by the International Society for Advancement of Cytometry during the CYTO2014 meeting in Fort Lauderdale, USA.
2013 Scholarship to attend the 7th European & Developing Countries Clinical Trials Partnership (EDCTP) Forum in Berlin
2010 Best Poster Prize at the VIII AIDS National Congress and X National Congress of Infectious Diseases

Título

2017 PhD with distinction and praise on Microbiology and Parasitology.
Universidade de Lisboa Faculdade de Medicina, Portugal

Outra distinção

2018 Seed Grant from The Australian Centre of Research Excellence in Malaria Elimination (15.000 AUD).