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Michael Duchen studied Medicine at the Oxford and London Universities, and was awarded his MB,BS degree in 1978. From 1978 to 1981 he served as a junior hospital doctor at the St Georges Hospital Group, and in 1981, obtained a postgraduate medical diploma from the Royal Colleges of Physicians (MRCP). In 1981 he was awarded a Bayliss-Starling Research scholarship to study for a PhD at University College London (UCL), where in 1984, he obtained his PhD. in Physiology. Michael remained at UCL, first as a Royal Society University Research Fellow (1984 to 1992) and then as Reader in Physiology (1992 to 1999). From 1999 to this day he is a Professor of Physiology at UCL, where he also Chaired the Basic Life Sciences Domain from 2011 to 2013. His research interests are related to the interplay between calcium signalling, mitochondria and free radicals in cell physiology and pathophysiology. Michael is specifically interested in characterizing the contributions of mitochondrial dysfunction to cell injury and cell death in ischaemia-reperfusion injury and in neurodegenerative diseases with the ultimate goal of identifying novel therapeutic pathways for otherwise intractable human disease. He is the author of 323 publications (ISI Web of Science) and has an H index of 88 (Google scholar). His recent work has been published in high impact factor, peer-reviewed journals which include Nature, Cell Metabolism, Nature Genetics, Nature Cell Biology, among others. Michael was awarded the Charles L Hoppel International prize in 2018 in recognition of his ‘outstanding contributions to mitochondrial research’. Michael was elected a Member of Academia Europaea in 2007, a Fellow of the Royal Society of Biologists in 2011, to the Council of the Bioenergetics group of the Biophysical Society in 2011 and a Fellow of the Royal College of Physicians since 2014. Michael has served on the International Scientific advisory board for: Myotubular trust, Mitochondrial Physiology Society (MiP); Italian Ministry of Education, University and Research; the Italian ALS charity AriSLA and the International Commission for Strategic Grants for the University of Padova; the Finnish Academy of Science; Qatar National Research Fund; The French Association National de Recherche. He has served on special NIH, BHF and MRC grant panels, including the quinquennial review panel for the MRC MBU. He Chairs the Bogue Research Fellowship committee at UCL. Michael has served on the Editorial Board of the Journal of Physiology and of the Journal of General Physiology. He is an Associate Editor of the Biochemical Journal in Bioenergetics, and a reviewing editor for Frontiers in Mitochondrial Research and for BMC Physiology. Michael’s scientific activity is currently funded by grants including equipment grants from the Wellcome Trust and the UCL Capital equipment fund, and project grants from the Michael J Fox Foundation, GOSH/Sparks, Biotechnology and Biological Sciences Research Council (BBSRC, BB/P018726/1), Mundipharma, and MSD (Merck) and the MRC (a CASE PhD studentship). Since 1989, he has supervised 26 PhD students and 36 post docs, of whom several are now Full Professors, several are clinical consultants, one is the Director of an Institute, and most of those who are still more junior are still working in science.
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Identificação

Identificação pessoal

Nome completo
Michael Duchen

Nomes de citação

  • Duchen, Michael
  • Duchen M.R.

Identificadores de autor

Ciência ID
8D1B-24B1-4444
ORCID iD
0000-0003-2548-4294

Endereços de correio eletrónico

  • m.duchen@ucl.ac.uk (Profissional)

Telefones

Telemóvel
  • (+44) 7932223427 (Pessoal)

Moradas

  • Department of Cell and Developmental Biology, UCL Gower Street, WC1E 6BT, Londn , London , Reino Unido (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica
Formação
Grau Classificação
1981 - 1984
Concluído
 PhD (Doctor of Philosophy)
Especialização em Physiology
University College London, Reino Unido
 NA
1975 - 1978
Concluído
 MB, BS (Bachelor)
Especialização em Medicine
St George's University of London, Reino Unido
 Distinction
1971/10/01 - 1975/06/01
Concluído
 BA (Bachelor)
Especialização em hysiology
University of Oxford, Reino Unido
 1st class
Percurso profissional

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
1984/10/01 - Atual Dirigente de laboratório, instituto, museu, centro ou observatório University College London, Reino Unido
University College London, Reino Unido
Projetos

Bolsa

Designação Financiadores
2023/08 - 2026/07 Role of microvascular dysfunction in mitochondrial disease: impact of mtDNA mutations on microvascular function as a cause of multisystem mitochondrial disease
PG/23/11425
 British Heart Foundation
2023/03 - 2026/02 Targeting Mitochondrial Dysfunction in iPSc-Derived Neurons from Vici Syndrome Patients: Towards Novel Treatments
GN2959
 Action Medical Research
2021 - 2024 causes and consequences of impaired metabolism in GBA1 related Parkinson’s Disease
G2103
Investigador responsável
University College London, Reino Unido
Em curso
2019 - 2023 Exploring novel treatment strategies for primary mitochondrial disease. Collaboration with Nannatherapeutics
MRC iCASE
Investigador responsável
Em curso
2019/01 - 2021/01 “Autophagy and mitochondrial dysfunction as potential therapeutic targets in GBA related Parkinson’s disease.”
12159
 Michael J Fox Foundation for Parkinson's Research
2014/06 - 2017/06 In situ quantification of metabolic function using fluorescence lifetime imaging
BB/L020874/1
 Biotechnology and Biological Sciences Research Council
2010 - 2015/12 ‘Understanding Parkinson’s disease: lessons from biology’
WT089698/Z/09/Z
 Wellcome Trust
2013/02 - 2015/01 KDAC inhibition and intracellular dynamics: impact on NEUROnal development, survival and transmission
124418
Provided by PTCRIS: 124418
 Universidade de Coimbra
2006/09 - 2011/09 Imaging the effects of inflammation and impulse activity on normal and demyelinated nerve tissue
G0500814
 Medical Research Council
2007/12 - 2010/11 Determining the effects of ischaemia and reperfusion in the intact heart using multi-photon microscopy
G0700933
 Medical Research Council
2005/12 - 2008/05 UCL Sepsis Group
G0500712
 Medical Research Council

Projeto

Designação Financiadores
2020 - 2023 Targeting pathways to metabolic dysfunction in Down syndrome-associated Alzheimer’s disease using iPSC derived neurons as a platform for drug discovery
NA
Investigador responsável
Produções

Publicações

Artigo em revista
  1. Gabriel E Valdebenito; Anitta R Chacko; Michael R Duchen. "The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target". The EMBO Journal (2023): https://doi.org/10.15252/embj.2023114141.
    10.15252/embj.2023114141
  2. Liliana M. Almeida; Brígida R. Pinho; Michael R. Duchen; Jorge M. A. Oliveira. "The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases". Biological Reviews (2022): https://doi.org/10.1111/brv.12860.
    10.1111/brv.12860
  3. "Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency". eLife 11 (2022): http://dx.doi.org/10.7554/elife.72595.
    10.7554/elife.72595
  4. Chi H; Bhosale G; Duchen MR. "Assessing the Redox Status of Mitochondria Through the NADH/FAD2+ Ratio in Intact Cells.". Methods in molecular biology (Clifton, N.J.) (2022): http://europepmc.org/abstract/med/35771452.
    10.1007/978-1-0716-2309-1_21
  5. "Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243¿A¿>¿G mtDNA mutation". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-26746-2.
    10.1038/s41467-021-26746-2
  6. "Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation". Life Sciences 285 (2021): 120009-120009. http://dx.doi.org/10.1016/j.lfs.2021.120009.
    10.1016/j.lfs.2021.120009
  7. "Rewiring cell signalling pathways in pathogenic mtDNA mutations". Trends in Cell Biology (2021): http://dx.doi.org/10.1016/j.tcb.2021.10.005.
    10.1016/j.tcb.2021.10.005
  8. "Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis in rats". British Journal of Anaesthesia 127 4 (2021): 577-586. http://dx.doi.org/10.1016/j.bja.2021.05.036.
    10.1016/j.bja.2021.05.036
  9. "The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy". Autophagy (2021): 1-22. http://dx.doi.org/10.1080/15548627.2021.1943177.
    10.1080/15548627.2021.1943177
  10. "Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines". International Journal of Molecular Sciences 22 11 (2021): 6117-6117. http://dx.doi.org/10.3390/ijms22116117.
    10.3390/ijms22116117
  11. "Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown". Trends in Neurosciences 44 5 (2021): 342-351. http://dx.doi.org/10.1016/j.tins.2021.01.001.
    10.1016/j.tins.2021.01.001
  12. "MitoSegNet: Easy-to-use Deep Learning Segmentation for Analyzing Mitochondrial Morphology". iScience 23 10 (2020): 101601-101601. http://dx.doi.org/10.1016/j.isci.2020.101601.
    10.1016/j.isci.2020.101601
  13. "Mitochondrial Signature in Human Monocytes and Resistance to Infection in C. elegans During Fumarate-Induced Innate Immune Training". Frontiers in Immunology 11 (2020): http://dx.doi.org/10.3389/fimmu.2020.01715.
    10.3389/fimmu.2020.01715
  14. "Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00051.
    10.3389/fcell.2020.00051
  15. Duchen, Michael. "Multiphoton NAD(P)H FLIM reveals metabolic changes in individual cell types of the intact cochlea upon sensorineural hearing loss.". Scientific reports (2019): https://europepmc.org/articles/PMC6906381.
    10.1038/s41598-019-55329-x
  16. Sean M. Davidson; Gyorgy Szabadkai; Michael R. Duchen. "Fantastic beasts and how to find them—Molecular identification of the mitochondrial ATP-sensitive potassium channel". Cell Calcium 84 (2019): 102100-102100. https://doi.org/10.1016/j.ceca.2019.102100.
    10.1016/j.ceca.2019.102100
  17. Duchen, Michael. "Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload.". Cell death and differentiation (2019): https://doi.org/10.1038/s41418-019-0442-2.
    10.1038/s41418-019-0442-2
  18. Duchen, Michael. "A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification.". Molecular and cellular biochemistry (2019): https://europepmc.org/articles/PMC6790197.
    10.1007/s11010-019-03593-w
  19. Duchen, Michael. "Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic ß-cells.". Nature communications (2019): https://europepmc.org/articles/PMC6554411.
    10.1038/s41467-019-10189-x
  20. Duchen, Michael. "Polarized Two-Photon Absorption and Heterogeneous Fluorescence Dynamics in NAD(P)H.". The journal of physical chemistry. B (2019): https://europepmc.org/articles/PMC6558641.
    10.1021/acs.jpcb.9b01236
  21. Duchen, Michael. "Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening.". Current protocols in pharmacology (2019): https://doi.org/10.1002/cpph.59.
    10.1002/cpph.59
  22. Duchen, Michael. "Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells.". World journal of stem cells (2019): https://europepmc.org/articles/PMC6545525.
    10.4252/wjsc.v11.i5.236
  23. Pollard AE; Martins L; Muckett PJ; Khadayate S; Bornot A; Clausen M; Admyre T; et al. "AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.". Nature metabolism (2019): http://europepmc.org/abstract/med/30887000.
    10.1038/s42255-019-0036-9
  24. Duchen, Michael. "Metabolic Profiling of Live Cancer Tissues Using NAD(P)H Fluorescence Lifetime Imaging.". Methods in molecular biology (Clifton, N.J.) (2019): https://doi.org/10.1007/978-1-4939-9027-6_19.
    10.1007/978-1-4939-9027-6_19
  25. Duchen, Michael. "Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets.". Trends in pharmacological sciences (2018): https://doi.org/10.1016/j.tips.2018.11.004.
    10.1016/j.tips.2018.11.004
  26. Soares TR; Reis SD; Pinho BR; Duchen MR; Oliveira JMA. "Targeting the proteostasis network in Huntington's disease.". Ageing research reviews (2018): http://europepmc.org/abstract/med/30502498.
    10.1016/j.arr.2018.11.006
  27. Duchen, Michael. "The role of mitochondria in sepsis-induced cardiomyopathy.". Biochimica et biophysica acta. Molecular basis of disease (2018): https://doi.org/10.1016/j.bbadis.2018.10.011.
    10.1016/j.bbadis.2018.10.011
  28. Martin W. Nicholson; Aaron Sweeney; Eva Pekle; Sabina Alam; Afia B. Ali; Michael Duchen; Jasmina N. Jovanovic. "Diazepam-induced loss of inhibitory synapses mediated by PLCd/ Ca2+/calcineurin signalling downstream of GABAA receptors". Molecular Psychiatry 23 9 (2018): 1851-1867. https://doi.org/10.1038/s41380-018-0100-y.
    10.1038/s41380-018-0100-y
  29. Duchen, Michael. "Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.". Nature reviews. Drug discovery (2018): https://europepmc.org/articles/PMC6456907.
    10.1038/nrd.2018.109
  30. Duchen, Michael. "Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients.". Human molecular genetics (2018): https://europepmc.org/articles/PMC6005141.
    10.1093/hmg/ddy149
  31. Duchen, Michael. "Decellularized Cartilage Directs Chondrogenic Differentiation: Creation of a Fracture Callus Mimetic.". Tissue engineering. Part A (2018): https://doi.org/10.1089/ten.TEA.2017.0450.
    10.1089/ten.tea.2017.0450
  32. Corrochano S; Blanco G; Williams D; Wettstein J; Simon M; Kumar S; Moir L; et al. "A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.". Human molecular genetics (2018): http://europepmc.org/abstract/med/29509900.
    10.1093/hmg/ddy077
  33. Duchen, Michael. "Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering.". Cell reports (2018): https://europepmc.org/articles/PMC5917451.
    10.1016/j.celrep.2018.03.091
  34. Duchen, Michael. "Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury.". Critical care medicine (2018): https://europepmc.org/articles/PMC5856355.
    10.1097/CCM.0000000000002937
  35. Duchen, Michael. "The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation, and mitochondrial abnormalities.". Journal of neurochemistry (2018): https://doi.org/10.1111/jnc.14293.
    10.1111/jnc.14293
  36. Sajic M; Ida KK; Canning R; Gregson NA; Duchen MR; Smith KJ. "Mitochondrial damage and "plugging" of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation.". Journal of neuroinflammation (2018): http://europepmc.org/abstract/med/29486771.
    10.1186/s12974-018-1094-8
  37. Davidson SM; Duchen MR. "Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single- or Two-Photon Confocal Microscopy.". Methods in molecular biology (Clifton, N.J.) (2018): http://europepmc.org/abstract/med/29851000.
    10.1007/978-1-4939-7831-1_10
  38. Duchen, Michael. "Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease.". Frontiers in cell and developmental biology (2017): https://europepmc.org/articles/PMC5732996.
    10.3389/fcell.2017.00110
  39. Duchen, Michael. "Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.". Cell death and differentiation (2017): https://europepmc.org/articles/PMC5864235.
    10.1038/s41418-017-0020-4
  40. Duchen, Michael. "Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of haemorrhagic shock.". British journal of anaesthesia (2017): https://doi.org/10.1016/j.bja.2017.11.074.
    10.1016/j.bja.2017.11.074
  41. Duchen, Michael. "Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability.". Scientific reports (2017): https://europepmc.org/articles/PMC5585167.
    10.1038/s41598-017-10673-8
  42. Pinto BB; Dyson A; Umbrello M; Carré JE; Ritter C; Clatworthy I; Duchen MR; Singer M. "Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand.". Critical care medicine (2017): http://europepmc.org/abstract/med/28410346.
    10.1097/ccm.0000000000002448
  43. Tsuchiya Y; Peak-Chew SY; Newell C; Miller-Aidoo S; Mangal S; Zhyvoloup A; Bakovic J; et al. "Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells.". The Biochemical journal (2017): http://europepmc.org/abstract/med/28341808.
    10.1042/bcj20170129
  44. Kon S; Ishibashi K; Katoh H; Kitamoto S; Shirai T; Tanaka S; Kajita M; et al. "Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.". Nature cell biology (2017): http://europepmc.org/abstract/med/28414314.
    10.1038/ncb3509
  45. Foote JR; Levine AP; Behe P; Duchen MR; Segal AW. "Imaging the Neutrophil Phagosome and Cytoplasm Using a Ratiometric pH Indicator.". Journal of visualized experiments : JoVE (2017): http://europepmc.org/abstract/med/28448042.
    10.3791/55107
  46. Blacker TS; Berecz T; Duchen MR; Szabadkai G. "Assessment of Cellular Redox State Using NAD(P)H Fluorescence Intensity and Lifetime.". Bio-protocol (2017): http://europepmc.org/abstract/med/28286806.
    10.21769/bioprotoc.2105
  47. McKenzie M; Lim SC; Duchen MR. "Simultaneous Measurement of Mitochondrial Calcium and Mitochondrial Membrane Potential in Live Cells by Fluorescent Microscopy.". Journal of visualized experiments : JoVE (2017): http://europepmc.org/abstract/med/28190045.
    10.3791/55166
  48. Plotegher N; Duchen MR. "Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders.". Trends in molecular medicine (2017): http://europepmc.org/abstract/med/28111024.
    10.1016/j.molmed.2016.12.003
  49. Bhosale G; Sharpe JA; Koh A; Kouli A; Szabadkai G; Duchen MR. "Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.". Biochimica et biophysica acta. Molecular cell research (2017): http://europepmc.org/abstract/med/28132899.
    10.1016/j.bbamcr.2017.01.015
  50. Blacker TS; Chen W; Avezov E; Marsh RJ; Duchen MR; Kaminski CF; Bain AJ. "Investigating State Restriction in Fluorescent Protein FRET Using Time-Resolved Fluorescence and Anisotropy.". The journal of physical chemistry. C, Nanomaterials and interfaces (2016): http://europepmc.org/abstract/med/28217242.
    10.1021/acs.jpcc.6b11235
  51. Chisholm KI; Ida KK; Davies AL; Tachtsidis I; Papkovsky DB; Dyson A; Singer M; Duchen MR; Smith KJ. "Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis.". (2016): http://europepmc.org/abstract/med/26661160.
    10.1177/0271678x15606457
  52. Briston T; Lewis S; Koglin M; Mistry K; Shen Y; Hartopp N; Katsumata R; et al. "Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria.". (2016): http://europepmc.org/abstract/med/27886240.
    10.1038/srep37798
  53. Blacker TS; Duchen MR. "Investigating mitochondrial redox state using NADH and NADPH autofluorescence.". (2016): http://europepmc.org/abstract/med/27519271.
    10.1016/j.freeradbiomed.2016.08.010
  54. Bolaños JP; Cadenas E; Duchen MR; Hampton MB; Mann GE; Murphy MP. "Introduction to Special Issue on Mitochondrial Redox Signaling in Health and Disease.". (2016): http://europepmc.org/abstract/med/27502830.
    10.1016/j.freeradbiomed.2016.08.004
  55. Guedes-Dias P; Pinho BR; Soares TR; de Proença J; Duchen MR; Oliveira JM. "Mitochondrial dynamics and quality control in Huntington's disease.". (2016): http://europepmc.org/abstract/med/26388396.
    10.1016/j.nbd.2015.09.008
  56. Corona JC; Duchen MR. "PPAR¿ as a therapeutic target to rescue mitochondrial function in neurological disease.". (2016): http://europepmc.org/abstract/med/27352979.
    10.1016/j.freeradbiomed.2016.06.023
  57. Tosatto A; Sommaggio R; Kummerow C; Bentham RB; Blacker TS; Berecz T; Duchen MR; et al. "The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1a.". (2016): http://europepmc.org/abstract/med/27138568.
    10.15252/emmm.201606255
  58. Hawkins KE; Joy S; Delhove JM; Kotiadis VN; Fernandez E; Fitzpatrick LM; Whiteford JR; et al. "NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming.". (2016): http://europepmc.org/abstract/med/26904936.
    10.1016/j.celrep.2016.02.003
  59. Warne J; Pryce G; Hill JM; Shi X; Lennerås F; Puentes F; Kip M; et al. "Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.". (2016): http://europepmc.org/abstract/med/26679998.
    10.1074/jbc.m115.700385
  60. Kilpatrick BS; Magalhaes J; Beavan MS; McNeill A; Gegg ME; Cleeter MW; Bloor-Young D; et al. "Endoplasmic reticulum and lysosomal Ca²¿ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts.". (2016): http://europepmc.org/abstract/med/26691915.
    10.1016/j.ceca.2015.11.002
  61. Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).". (2016): http://europepmc.org/abstract/med/26799652.
    10.1080/15548627.2015.1100356
  62. Chisholm KI; Ida KK; Davies AL; Papkovsky DB; Singer M; Dyson A; Tachtsidis I; Duchen MR; Smith KJ. "In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue.". (2016): http://europepmc.org/abstract/med/26782217.
    10.1007/978-1-4939-3023-4_29
  63. McKenzie M; Duchen MR. "Impaired Cellular Bioenergetics Causes Mitochondrial Calcium Handling Defects in MT-ND5 Mutant Cybrids.". (2016): http://europepmc.org/abstract/med/27110715.
    10.1371/journal.pone.0154371
  64. Sadeghian M; Mastrolia V; Rezaei Haddad A; Mosley A; Mullali G; Schiza D; Sajic M; et al. "Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis.". (2016): http://europepmc.org/abstract/med/27624721.
    10.1038/srep33249
  65. Davidson SM; Foote K; Kunuthur S; Gosain R; Tan N; Tyser R; Zhao YJ; et al. "Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.". (2015): http://europepmc.org/abstract/med/26395965.
    10.1093/cvr/cvv226
  66. Guedes-Dias P; de Proença J; Soares TR; Leitão-Rocha A; Pinho BR; Duchen MR; Oliveira JM. "HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons.". (2015): http://europepmc.org/abstract/med/26300485.
    10.1016/j.bbadis.2015.08.012
  67. Shahni R; Cale CM; Anderson G; Osellame LD; Hambleton S; Jacques TS; Wedatilake Y; et al. "Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.". (2015): http://europepmc.org/abstract/med/26122121.
    10.1093/brain/awv182
  68. Nickel AG; von Hardenberg A; Hohl M; Löffler JR; Kohlhaas M; Becker J; Reil JC; et al. "Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.". (2015): http://europepmc.org/abstract/med/26256392.
    10.1016/j.cmet.2015.07.008
  69. Bhosale G; Sharpe JA; Sundier SY; Duchen MR. "Calcium signaling as a mediator of cell energy demand and a trigger to cell death.". (2015): http://europepmc.org/abstract/med/26375864.
    10.1111/nyas.12885
  70. Ikaga R; Namekata I; Kotiadis VN; Ogawa H; Duchen MR; Tanaka H; Iida-Tanaka N. "Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells.". Biochemistry and biophysics reports (2015): http://europepmc.org/abstract/med/29124204.
    10.1016/j.bbrep.2015.09.009
  71. Zolfaghari PS; Carré JE; Parker N; Curtin NA; Duchen MR; Singer M. "Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis.". (2015): http://europepmc.org/abstract/med/25714676.
    10.1152/ajpendo.00562.2014
  72. Corona JC; Duchen MR. "Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?". (2015): http://europepmc.org/abstract/med/25216534.
    10.1007/s10863-014-9576-6
  73. Llorente-Folch I; Rueda CB; Pardo B; Szabadkai G; Duchen MR; Satrustegui J. "The regulation of neuronal mitochondrial metabolism by calcium.". (2015): http://europepmc.org/abstract/med/25809592.
    10.1113/JP270254
  74. Corona JC; Duchen MR. "PPAR¿ and PGC-1a as therapeutic targets in Parkinson's.". (2015): http://europepmc.org/abstract/med/25007880.
    10.1007/s11064-014-1377-0
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Pré-impressão
  1. De la Rossa A; Laporte MH; Astori S; Marissal T; Montessuit S; Sheshadri P; Ramos-Fernández E; et al. "Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency". 2020. http://europepmc.org/abstract/PPR/PPR255792.
    10.1101/2020.12.22.423903
Distinções

Prémio

2024 Keilin medal and lecture
Biochemical Society, Reino Unido
2018 Charles Hoppel Prize
Case Western Reserve University, Estados Unidos

Outra distinção

2007 Member of Academia Europaea
Academia Europaea, Reino Unido