Vera Mónica Miranda Gonçalves (8E1B-B722-284F)

Curriculum Vitae

Vera Mónica Miranda Gonçalves

I am a junior researcher at the Cancer Biology & Epigenetics Group (CBEG) in the Research Center of the Portuguese Oncology Institute of Porto (CI-IPOP). With a Scopus h-index of 25, I have published 56 papers in international peer-reviewed journals and 4 book chapters, accumulating 2014 citations and an impact factor of 330, indicating a significant impact in my field. I have been the first author on 12 papers and the senior author on 1. My scientific career began at the Centre for Neurosciences and Cell Biology - Vectors and Gene Therapy Lab, where I developed her BSc thesis on Liposomal vectors for cancer cell lines targeting. In 2008, I joined the Cancer Metabolism Group as a Fellowship Researcher at the Life and Health Sciences Research Institute (ICVS). In 2016, I obtained her PhD in Health Sciences from the School of Medicine, University of Minho, where I worked on Monocarboxylate Transporters (MCTs) in gliomas: Regulation and therapeutic implications, also at the Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil. I moved to CI-IPOP in 2017 through a post-doctoral fellowship, and since January 2019, I have held a contract as a junior researcher (January 2019-June 2021 - FCT: POCI-01-0145-FEDER-29043; from July 2021 onwards - NORTE-01-0145-FEDER-072678). During my time at CI-IPOP, I have worked on several projects addressing the impact of epigenetics on tumour progression and therapy resistance, co-authoring 23 papers with an accumulated impact factor of 187. My research interests integrate Oncobiology (Urological Tumors), with a focus on the crossroads between tumour metabolism, cancer epigenetics and radiotherapy. I have consolidated a significant scientific output in the tumour metabolism and cancer epigenetic areas, allowing for the implementation of important skills for my research line implementation: Tumour Metabolism & Epigenetics crosstalk in cancer. So far, this has resulted in 3 review papers, 2 original papers (1 as the last author), and 1 book chapter within this research topic. In this research area, I have an accumulated impact factor of 27. Since 2017, I have participated in the supervision of 1 BSc student, 11 MSc students, and since 2020, I have been enrolled as supervisor of 2 PhD students. I am an active member of the scientific community, contributing to the lecturing of practical and theoretical classes from MSc/PhD programs in Medicine and Molecular Oncology at FMUP, and from the MSc program in Oncology at ICBAS-UP. Additionally, I was an invited assistant professor (30%) at the School of Health Sciences - Polytechnic of Porto (ESS-UP), where I teached the curricular unit Oncobiology. My work has been nationally and internationally recognized through 8 selected oral presentations in scientific meetings, invitations to review for Clinical Epigenetics, BMC Cancer, Cancers, among others, and participation in 9 scientific juries. I currently manage and supervise the MCTKidCan, EpiMetaboK, and EpiPaRty-funded projects and I am also a member of the H2020 Marie Sklodowska-Curie Action - PROSTAMET.

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Identificação

Identificação pessoal

Nome completo: Vera Mónica Miranda Gonçalves

Nomes de citação

Vera Miranda-Gonçalves

Identificadores de autor

Ciência ID: 8E1B-B722-284F
ORCID iD: 0000-0002-4231-5532
Scopus Author Id: 47361242700

Endereços de correio eletrónico

vera.miranda.goncalves@ipoporto.min-saude.pt (Profissional)

Telefones

Telefone

225084000 Ext.: 1953 (Profissional)

Moradas

Research Center of Portuguese Oncology Institute of Porto . Rua Dr. António Bernardino de Almeida , 4200-072, Porto, Porto, Portugal (Profissional)

Websites

http://www.ipoporto.pt/eu-profissional/investigacao/centro-de-investigacao/ (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Ciências da Saúde
Ciências Naturais - Ciências Biológicas - Bioquímica
Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)
Português (Idioma materno)

Formação

	Grau	Classificação
2024/11/05 - 2024/11/26 Concluído	Advanced R programming for multi-omics data analysis (Outros) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2018 Concluído	Advanced Training Course in Human Laboratory Genetics - Molecular Genetics (Outros) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	14
2018 Concluído	Advanced Training Course in Human Laboratory Genetics - Biochemical Genetics (Outros) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	18
2018 Concluído	Advanced Training Course in Human Laboratory Genetics - Clinical Laboratory Genetics (Outros) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	18
2012 - 2016 Concluído	PhD in Health Scencies (Doutoramento) Universidade do Minho Escola de Medicina, Portugal "Monocarboxylate Transporters in gliomas: regulation and therapeutic implications" (TESE/DISSERTAÇÃO)	Muito Bom
2015 Concluído	Controversies and Development in Gastric Cancer (Outros) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2014 Concluído	Bioinformatics mini-course (Outros) São Paulo School of Advanced Sciences, Brasil
2013 Concluído	Laboratorial Rotation - Tumor metabolic plasticity: Gluconeogenesis pathway as an alternative source of glucose (Outros) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal	19
2013 Concluído	Laboratorial Rotation - Oxidative stress: Cell death mechanism of Parthenolide in Diffuse Large B cell Lymphoma (Outros) Universidade de Coimbra Faculdade de Medicina, Portugal	19
2010 - 2012 Concluído	MSc in Health Sciences (Mestrado) Universidade do Minho Escola de Medicina, Portugal "Role of monocarboxylate transporters in the metabolic remodelling of glioblastomas" (TESE/DISSERTAÇÃO)	17
2011 Concluído	An Integrative Approach to Cell Analysis (Outros) Universidade do Minho Escola de Medicina, Portugal	16
2010 Concluído	Radioactive Materials: How to deal with radioactive material (Outros) Universidade do Minho Escola de Medicina, Portugal
2010 Concluído	Biostatistics in Health Sciences (Outros) Universidade do Minho Escola de Medicina, Portugal	14
2010 Concluído	Laboratory Animal Sciences (Outros) Universidade do Minho Escola de Medicina, Portugal	16
2010 Concluído	Bioinformatics in Health Sciences (Outros) Universidade do Minho Escola de Medicina, Portugal	18
2009 Concluído	Applications of flow cytometry in biomedical research (Outros) Universidade do Minho Escola de Medicina, Portugal
2004 - 2008 Concluído	BSc in Biochemistry (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Targeting of Lipossomal Vectors for cancer cell lines" (TESE/DISSERTAÇÃO)	16
2007 Concluído	Voluntary Internship - Clinical Analysis (Outros) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2019/01/02 - Atual	Investigador (Investigação)	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2017 - 2018	Pós-doutorado (Investigação)	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

2008 - 2012	Assistente de Investigação (carreira) (Investigação)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2019 - Atual	Professor Auxiliar Convidado (Docente Universitário)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/03/27 - 2023/07/28	Assistente convidado (Docente Ensino Superior Politécnico)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2012 - 2016	PhD Fellowship	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

2014/06 - 2014/10	PhD student	Centro de Pesquisa em Oncologia Molecular, Hospital do Câncer de Barretos, Brasil
	Centro de Pesquisa em Oncologia Molecular, Hospital do Câncer de Barretos, Brasil

Projetos

Bolsa

	Designação	Financiadores
2024/01/01 - Atual	DNA methylation-based biomarkers as a novel minimal invasive technique for prostate cancer prognostication upon radiotherapeutic treatment (MethProstaR) LPCC NRN 2024 Orientador Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Liga Portuguesa Contra o Cancro Núcleo Regional do Norte Em curso
2022/01 - 2022/12	The role of VHL/HIF axis- dependent metabolic profile in clear cell renal cell carcinoma aggressiveness LPCC NRN 2022 Orientador Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Liga Portuguesa Contra o Cancro Núcleo Regional do Norte Em curso
2017 - 2018	ESTIMA: Early-stage cancer treatment, driven by context of molecular imaging NORTE-01-0145-FEDER-000027 Bolseiro de Pós-Doutoramento Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Fundação para a Ciência e a Tecnologia Em curso

Projeto

	Designação	Financiadores
2018/08/10 - 2021/12/31	ACCuseD renAl Cell Carcinoma Detection Renal Cancer detection: a translational metabolomics research based on Volatile Organic Compounds fingerprinting PTDC/SAU-SER/30388/2017 Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Fundação Ensino e Cultura Fernando Pessoa, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019 - 2021	Development of novel prognostic and predictive epigenetic biomarkers for malignant testicular germ cell tumors POCI-01-0145-FEDER-29043 Investigador Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011 - 2014	Potential predictive biomarkers of anti-RTKs therapy response in gliomas: An “in vitro” and “in vivo” Study info:eu-repo/grantAgreement/FCT/5876-PPCDTI/114549/PT Outra Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/04/01 - 2013/06/30	Transportadores de monocarboxilatos como potenciais alvos terapêuticos em cancro: estudos de inibição em modelos de tumores sólidos PTDC/SAU-FCF/104347/2008 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/04/01 - 2013	Role of monocarboxylate transporters (MCTs) in the metabolism of prostate cancer info:eu-repo/grantAgreement/FCT/5876-PPCDTI/113415/PT Outra Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Outro

	Designação	Financiadores
2023 - Atual	PROSTAMET - A comprehensive Translational Research and Training Pipeline Harnessing Lipid Metabolism to Improve PROSTate Cancer Management and Educate Young Researchers in Tackling Complex Disease 101120283 Investigador Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions Em curso
2022 - Atual	EpiMetaboK: Epitrasnciptomic alterations within renal cancer metabolism reprogramming: uncovering new targets CI-IPOP 08-2022 Investigador Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	Instituto Português de Oncologia do Porto Francisco Gentil EPE Em curso
2020 - Atual	EpiPaRty: Dissecting the interplay between epigenetics and radiotherapy resistance in prostate cancer CI-IPOP-152-2021 Investigador Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	Instituto Português de Oncologia do Porto Francisco Gentil EPE Em curso
2017 - Atual	MCTKidCan: epigenetics and tumour metabolism crosstalk in kidney cancer CI-IPOP-92-2018 Investigador Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação Em curso
2013 - 2016	Estudo do efeito antineoplásico de extratos e derivados de Euphorbia tirucalli em tumores cerebrais e células tronco tumorais cerebrais MCTI/CNPq Nº73/2013 Outra Hospital de Câncer de Barretos, Brasil	Conselho Nacional de Desenvolvimento Científico e Tecnológico Concluído

Produções

Publicações

Artigo em revista	Mariana Cantante; Vera Miranda-Gonçalves; Nuno Tiago Tavares; Rita Guimarães; Isaac Braga; Joaquina Maurício; Andres M. Acosta; et al. "Differential expression of metabolic enzymes in testicular germ cell tumors: The impact of glycolytic metabolism in embryonal carcinoma histotype". Andrology (2024): https://doi.org/10.1111/andr.13824. 10.1111/andr.13824 Nair Lopes; Sofia Salta; Bianca Troncarelli Flores; Vera Miranda-Gonçalves; Margareta P. Correia; Davide Gigliano; Rita Guimarães; Rui Henrique; Carmen Jerónimo. "Anti-tumour activity of Panobinostat in oesophageal adenocarcinoma and squamous cell carcinoma cell lines". Clinical Epigenetics (2024): http://dx.doi.org/10.1186/s13148-024-01700-3. 10.1186/s13148-024-01700-3 Catarina Macedo-Silva; Vera Miranda-Gonçalves; Nuno Tiago Tavares; Daniela Barros-Silva; Joana Lencart; João Lobo; Ângelo Oliveira; et al. "Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling". Signal Transduction and Targeted Therapy (2023): http://dx.doi.org/10.1038/s41392-023-01639-6. 10.1038/s41392-023-01639-6 Catarina Macedo-Silva; Vera Constâncio; Vera Miranda-Gonçalves; Pedro Leite-Silva; Sofia Salta; João Lobo; Rita Guimarães; et al. "DNA methylation biomarkers accurately detect esophageal cancer prior and post neoadjuvant chemoradiation". Cancer Medicine 12 7 (2023): 8777-8788. http://dx.doi.org/10.1002/cam4.5623. Publicado • 10.1002/cam4.5623 Sara Monteiro-Reis; Vera Miranda-Gonçalves; Catarina Guimarães-Teixeira; Cláudia Martins-Lima; João Lobo; Diana Montezuma; Paula C. Dias; et al. "Vimentin epigenetic deregulation in Bladder Cancer associates with acquisition of invasive and metastatic phenotype through epithelial-to-mesenchymal transition". International Journal of Biological Sciences 19 1 (2023): 1-12. http://dx.doi.org/10.7150/ijbs.77181. Publicado • 10.7150/ijbs.77181 Martins, Eduarda P.; Gonçalves, Céline S.; Pojo, Marta; Carvalho, Rita; Ribeiro, Ana S.; Miranda-Gonçalves, Vera; Taipa, Ricardo; et al. "Cadherin-3 is a novel oncogenic biomarker with prognostic value in glioblastoma". Molecular Oncology (2022): http://dx.doi.org/10.1002/1878-0261.13162. Publicado • 10.1002/1878-0261.13162 Florian A. Büttner; Stefan Winter; Viktoria Stühler; Steffen Rausch; Jörg Hennenlotter; Susanne Füssel; Stefan Zastrow; et al. "A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy". Genome Medicine 14 1 (2022): http://dx.doi.org/10.1186/s13073-022-01105-y. Publicado • 10.1186/s13073-022-01105-y Ana Salomé Correia; D. Duarte; Vera Miranda-Gonçalves; Nuno Vale. "Potential Translational Thioflavin T Methodology as a Complement of Cell-Based Assays and after Drug Exposition". International Journal of Translational Medicine (2022): https://www.mdpi.com/2673-8937/2/2/11. 10.3390/ijtm2020011 Beatriz Chaves Lourenço; Catarina Guimarães-Teixeira; Bianca C. T. Flores; Vera Miranda-Gonçalves; Rita Guimarães; Mariana Cantante; Paula Lopes; et al. "Ki67 and LSD1 Expression in Testicular Germ Cell Tumors Is Not Associated with Patient Outcome: Investigation Using a Digital Pathology Algorithm". Life 12 2 (2022): 264-264. https://doi.org/10.3390/life12020264. Publicado • 10.3390/life12020264 Cláudia Martins-Lima; Vera Miranda-Gonçalves; João Lobo; Vera Constâncio; Pedro Leite-Silva; Catarina Guimarães-Teixeira; Sara Monteiro-Reis; et al. "Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression". Cellular Oncology (2022): https://doi.org/10.1007/s13402-021-00657-2. Publicado • 10.1007/s13402-021-00657-2 Guimarães-Teixeira, Catarina; Lobo, João; Miranda-Gonçalves, Vera; Barros-Silva, Daniela; Martins-Lima, Cláudia; Monteiro-Reis, Sara; Sequeira, José Pedro; et al. "Downregulation of m6A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness". Molecular Oncology (2022): http://dx.doi.org/10.1002/1878-0261.13181. Publicado • 10.1002/1878-0261.13181 Catarina Guimarães-Teixeira; Daniela Barros-Silva; João Lobo; Diana Soares-Fernandes; Vera Constâncio; Pedro Leite-Silva; Rui Silva-Santos; et al. Autor correspondente: Vera Miranda-Gonçalves. "Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes". Journal of Personalized Medicine 11 10 (2021): https://doi.org/10.3390/jpm11100996. Publicado • 10.3390/jpm11100996 Marques-Magalhães, Ângela; Graça, Inês; Miranda-Gonçalves, Vera; Henrique, Rui; Lopez, Marie; Arimondo, Paola B.; Jerónimo, Carmen. "Anti-neoplastic and demethylating activity of a newly synthetized flavanone-derived compound in Renal Cell Carcinoma cell lines". Biomedicine & Pharmacotherapy 141 (2021): 111681. http://dx.doi.org/10.1016/j.biopha.2021.111681. Publicado • 10.1016/j.biopha.2021.111681 Vera Miranda-Gonçalves; João Lobo; Catarina Guimarães-Teixeira; Daniela Barros-Silva; Rita Guimarães; Mariana Cantante; Isaac Braga; et al. "The component of the m6A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors". Journal of Experimental & Clinical Cancer Research (2021): https://doi.org/10.1186/s13046-021-02072-9. Publicado • 10.1186/s13046-021-02072-9 Vera Miranda-Gonçalves; Céline S. Gonçalves; Sara Granja; Joana Vieira de Castro; Rui M. Reis; Bruno M. Costa; Fátima Baltazar. "MCT1 Is a New Prognostic Biomarker and Its Therapeutic Inhibition Boosts Response to Temozolomide in Human Glioblastoma". Cancers 13 14 (2021): 3468-3468. https://doi.org/10.3390/cancers13143468. Publicado • 10.3390/cancers13143468 Talukdar, Fazlur Rahman; Soares Lima, Sheila C.; Khoueiry, Rita; Laskar, Ruhina Shirin; Cuenin, Cyrille; Sorroche, Bruna Pereira; Boisson, Anne-Claire; et al. "Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers". Cancer Research 81 10 (2021): 2612-2624. http://dx.doi.org/10.1158/0008-5472.can-20-3445. Publicado • 10.1158/0008-5472.can-20-3445 João Lobo; Vera Constâncio; Catarina Guimarães-Teixeira; Pedro Leite-Silva; Vera Miranda-Gonçalves; José Pedro Sequeira; Laura Pistoni; et al. "Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors.". Molecular oncology (2021): https://doi.org/10.1002/1878-0261.12909. Publicado • 10.1002/1878-0261.12909 João Lobo; Ana Rita Cardoso; Vera Miranda-Gonçalves; Leendert H. J. Looijenga; Marie Lopez; Paola B. Arimondo; Rui Henrique; Carmen Jerónimo. "Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest". Pharmaceutics 13 1 (2021): 73-73. https://doi.org/10.3390/pharmaceutics13010073. Publicado • 10.3390/pharmaceutics13010073 Filipa Quintela Vieira; Ângela Marques-Magalhães; Vera Miranda-Gonçalves; Ricardo Ferraz; Mónica Vieira; Cristina Prudêncio; Carmen Jerónimo; Regina Augusta Silva. "The Impact of [C16Pyr][Amp] on the Aggressiveness in Breast and Prostate Cancer Cell Lines". International Journal of Molecular Sciences 21 24 (2020): 9584-9584. https://doi.org/10.3390/ijms21249584. Publicado • 10.3390/ijms21249584 Catarina Macedo-Silva; Vera Miranda-Gonçalves; Ana Lameirinhas; Joana Lencart; Alexandre Pereira; João Lobo; Rita Guimarães; et al. "JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma.". Cell death & disease (2020): https://doi.org/10.1038/s41419-020-03279-y. Publicado • 10.1038/s41419-020-03279-y Sofia Salta; Catarina Macedo-Silva; Vera Miranda-Gonçalves; Nair Lopes; David Gigliano; Rita Guimarães; Mónica Farinha; et al. "A DNA methylation-based test for esophageal cancer detection.". Biomarker research (2020): https://europepmc.org/articles/PMC7691099. Publicado • 10.1186/s40364-020-00248-7 Andreia Pereira-Nunes; Susana Simões-Sousa; Céline Pinheiro; Vera Miranda-Gonçalves; Sara Granja; Fátima Baltazar, PhD. "Targeting lactate production and efflux in prostate cancer". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 11 (2020): 165894-165894. http://dx.doi.org/10.1016/j.bbadis.2020.165894. 10.1016/j.bbadis.2020.165894 João Lobo; Catarina Guimarães-Teixeira; Daniela Barros-Silva; Vera Miranda-Gonçalves; Vânia Camilo; Rita Guimarães; Mariana Cantante; et al. "Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors". Cancers (2020): https://doi.org/10.3390/cancers12102903. 10.3390/cancers12102903 João Lobo; Rita Guimarães; Vera Miranda-Gonçalves; Sara Monteiro-Reis; Mariana Cantante; Luís Antunes; Isaac Braga; et al. "Differential expression of DNA methyltransferases and demethylases among the various testicular germ cell tumor subtypes". Epigenomics 12 18 (2020): 1579-1592. http://dx.doi.org/10.2217/epi-2020-0066. 10.2217/epi-2020-0066 Ana Rita Cardoso; João Lobo; Vera Miranda-Gonçalves; Rui Henrique; Carmen Jerónimo. "Epigenetic alterations as therapeutic targets in Testicular Germ Cell Tumours : current and future application of ‘epidrugs’". Epigenetics (2020): https://doi.org/10.1080/15592294.2020.1805682. 10.1080/15592294.2020.1805682 Vera Miranda-Gonçalves; Ana Lameirinhas; Rui Henrique; Fátima Baltazar; Carmen Jerónimo. "The metabolic landscape of urological cancers: New therapeutic perspectives". Cancer Letters 477 (2020): 76-87. https://doi.org/10.1016/j.canlet.2020.02.034. 10.1016/j.canlet.2020.02.034 Filipa Amaro; Joana Pinto; Sílvia Rocha; Ana Margarida Araújo; Vera Miranda-Gonçalves; Carmen Jerónimo; Rui Henrique; et al. "Volatilomics Reveals Potential Biomarkers for Identification of Renal Cell Carcinoma: An In Vitro Approach". Metabolites 10 5 (2020): 174-174. https://doi.org/10.3390/metabo10050174. 10.3390/metabo10050174 Sara Monteiro-Reis; Ana Lameirinhas; Vera Miranda-Gonçalves; Diana Felizardo; Paula C. Dias; Jorge Oliveira; Inês Graça; et al. "Sirtuins’ Deregulation in Bladder Cancer: SIRT7 Is Implicated in Tumor Progression through Epithelial to Mesenchymal Transition Promotion". Cancers 12 5 (2020): 1066-1066. http://dx.doi.org/10.3390/cancers12051066. 10.3390/cancers12051066 Vera Miranda-Gonçalves; Ana Lameirinhas; Catarina Macedo-Silva; João Lobo; Paula C. Dias; Verónica Ferreira; Rui Henrique; Carmen Jerónimo. "Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation". Cells (2020): Publicado Vera Miranda-Gonçalves. "The T-box transcription factor brachyury behaves as a tumor suppressor in gliomas.". The Journal of pathology (2020): https://doi.org/10.1002/path.5419. 10.1002/path.5419 Catarina Macedo-Silva; Vera Miranda-Gonçalves; Rui Henrique; Carmen Jerónimo; Isabel Bravo. "The Critical Role of Hypoxic Microenvironment and Epigenetic Deregulation in Esophageal Cancer Radioresistance". Genes (2019): http://dx.doi.org/10.3390/genes10110927. Publicado • 10.3390/genes10110927 Lobo; Nunes; Gillis; Barros-Silva; Miranda-Gonçalves; Berg; Cantante; et al. "XIST-Promoter Demethylation as Tissue Biomarker for Testicular Germ Cell Tumors and Spermatogenesis Quality". Cancers 11 9 (2019): 1385. http://dx.doi.org/10.3390/cancers11091385. Publicado • 10.3390/cancers11091385 Ana Lameirinhas; Vera Miranda-Gonçalves; Rui Henrique; Carmen Jeronimo. "The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma". Genes (2019): https://www.mdpi.com/2073-4425/10/4/264. Publicado • 10.3390/genes10040264 Miranda-Gonçalves, V.; Lameirinhas, A.; Henrique, R.; Jerónimo, C.. "Metabolism and epigenetic interplay in cancer: Regulation and putative therapeutic targets". Frontiers in Genetics 9 OCT (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055323422&partnerID=MN8TOARS. 10.3389/fgene.2018.00427 Silva, V.A.O.; Rosa, M.N.; Miranda-Gonçalves, V.; Costa, A.M.; Tansini, A.; Evangelista, A.F.; Martinho, O.; et al. "Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells". Investigational New Drugs (2018): 1-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048839289&partnerID=MN8TOARS. 10.1007/s10637-018-0620-y Vilaça, N.; Totovao, R.; Prasetyanto, E.A.; Miranda-Gonçalves, V.; Morais-Santos, F.; Fernandes, R.; Figueiredo, F.; et al. "Internalization studies on zeolite nanoparticles using human cells". Journal of Materials Chemistry B 6 3 (2018): 469-476. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040868389&partnerID=MN8TOARS. 10.1039/c7tb02534c Ferreira, N.N.; M.B. Ferreira, L.; Miranda-Gonçalves, V.; Reis, R.M.; Seraphim, T.V.; Borges, J.C.; Baltazar, F.; Gremião, M.P.D.. "Alginate hydrogel improves anti-angiogenic bevacizumab activity in cancer therapy". European Journal of Pharmaceutics and Biopharmaceutics 119 (2017): 271-282. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021992926&partnerID=MN8TOARS. 10.1016/j.ejpb.2017.06.028 Miranda-Gonçalves, V.; Bezerra, F.; Costa-Almeida, R.; Freitas-Cunha, M.; Soares, R.; Martinho, O.; Reis, R.M.; Pinheiro, C.; Baltazar, F.. "Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk". Molecular Carcinogenesis 56 12 (2017): 2630-2642. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028302772&partnerID=MN8TOARS. 10.1002/mc.22707 Miranda-Gonçalves, V.; Cardoso-Carneiro, D.; Valbom, I.; Cury, F.P.; Silva, V.A.; Granja, S.; Reis, R.M.; Baltazar, F.; Martinho, O.. "Metabolic alterations underlying Bevacizumab therapy in glioblastoma cells". Oncotarget 8 61 (2017): 103657-103670. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035349210&partnerID=MN8TOARS. 10.18632/oncotarget.21761 Martinho, Olga; Silva-Oliveira, Renato; Cury, Fernanda P.; Barbosa, Ana Martins; Granja, Sara; Evangelista, Adriane Feijó; Marques, Fábio; et al. "HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors". Theranostics 7 3 (2017): 717-732. http://dx.doi.org/10.7150/thno.17154. Publicado • 10.7150/thno.17154 Pinheiro, C.; Miranda-Gonçalves, V.; Longatto-Filho, A.; Vicente, A.L.S.A.; Berardinelli, G.N.; Scapulatempo-Neto, C.; Costa, R.F.A.; et al. "The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4". Cell Cycle 15 11 (2016): 1462-1470. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969138646&partnerID=MN8TOARS. 10.1080/15384101.2016.1175258 Yan, L.-P.; Silva-Correia, J.; Ribeiro, V.P.; Miranda-Goncalves, V.; Correia, C.; Da Silva Morais, A.; Sousa, R.A.; et al. "Tumor Growth Suppression Induced by Biomimetic Silk Fibroin Hydrogels". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84982730530&partnerID=MN8TOARS. 10.1038/srep31037 Miranda-Gonçalves, V.; Granja, S.; Martinho, O.; Honavar, M.; Pojo, M.; Costa, B.M.; Pires, M.M.; et al. "Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas". Oncotarget 7 29 (2016): 46335-46353. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979950555&partnerID=MN8TOARS. 10.18632/oncotarget.10114 Miranda-Gonçalves, V.; Reis, R.M.; Baltazar, F.. "Lactate transporters and pH regulation: Potential therapeutic targets in glioblastomas". Current Cancer Drug Targets 16 5 (2016): 388-399. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973664272&partnerID=MN8TOARS. 10.2174/1568009616666151222150543 Amorim, R.; Pinheiro, C.; Miranda-Gonçalves, V.; Pereira, H.; Moyer, M.P.; Preto, A.; Baltazar, F.. "Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells". Cancer Letters 365 1 (2015): 68-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930823940&partnerID=MN8TOARS. 10.1016/j.canlet.2015.05.015 Afonso, J.; Santos, L.L.; Miranda-Gonçalves, V.; Morais, A.; Amaro, T.; Longatto-Filho, A.; Baltazar, F.. "CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance". Molecular Carcinogenesis 54 11 (2015): 1451-1466. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945189106&partnerID=MN8TOARS. 10.1002/mc.22222 Morais-Santos, F.; Granja, S.; Miranda-Gonçalves, V.; Moreira, A.H.J.; Queirós, S.; Vilaça, J.L.; Schmitt, F.C.; et al. "Targeting lactate transport suppresses in vivo breast tumour growth". Oncotarget 6 22 (2015): 19177-19189. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938895687&partnerID=MN8TOARS. 10.18632/oncotarget.3910 Silva-Carvalho, R.; Miranda-Gonçalves, V.; Ferreira, A.M.; Cardoso, S.M.; Sobral, A.J.F.N.; Almeida-Aguiar, C.; Baltazar, F.. "Antitumoural and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models". Journal of Functional Foods 11 C (2014): 160-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926359911&partnerID=MN8TOARS. 10.1016/j.jff.2014.09.009 Morais-Santos, F.; Miranda-Gonçalves, V.; Pinheiro, S.; Vieira, A.F.; Paredes, J.; Schmitt, F.C.; Baltazar, F.; Pinheiro, C.. "Differential sensitivities to lactate transport inhibitors of breast cancer cell lines". Endocrine-Related Cancer 21 1 (2014): 27-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893558970&partnerID=MN8TOARS. 10.1530/ERC-13-0132 Valença, I.; Morais-Santos, F.; Miranda-Gonçalves, V.; Ferreira, A.M.; Almeida-Aguiar, C.; Baltazar, F.. "Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro". BMC Complementary and Alternative Medicine 13 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880334946&partnerID=MN8TOARS. 10.1186/1472-6882-13-184 Martinho, O.; Silva-Oliveira, R.; Miranda-Gonçalves, V.; Clara, C.; Almeida, J.R.; Carvalho, A.L.; Barata, J.T.; Reis, R.M.. "In vitro and in vivo analysis of RTK inhibitor efficacy and identification of its novel targets in glioblastomas". Translational Oncology 6 2 (2013): 187-196. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875783182&partnerID=MN8TOARS. 10.1593/tlo.12400 Miranda-Gonçalves, V.; Honavar, M.; Pinheiro, C.; Martinho, O.; Pires, M.M.; Cordeiro, M.; Bebiano, G.; et al. "Monocarboxylate transporters (MCTs) in gliomas: Expression and exploitation as therapeutic targets". Neuro-Oncology 15 2 (2013): 172-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875731196&partnerID=MN8TOARS. 10.1093/neuonc/nos298 Granja, S.; Morais-Santos, F.; Miranda-Gonçalves, V.; Viana-Ferreira, M.; Nogueira, R.; Nogueira-Silva, C.; Correia-Pinto, J.; Baltazar, F.. "The monocarboxylate transporter inhibitor a-cyano-4-hydroxycinnamic acid disrupts rat lung branching". Cellular Physiology and Biochemistry 32 6 (2013): 1845-1856. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890530426&partnerID=MN8TOARS. 10.1159/000356617 Martinho, O.; Pinto, F.; Granja, S.; Miranda-Gonçalves, V.; Moreira, M.A.R.; Ribeiro, L.F.J.; di Loreto, C.; et al. "RKIP Inhibition in Cervical Cancer Is Associated with Higher Tumor Aggressive Behavior and Resistance to Cisplatin Therapy". PLoS ONE 8 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875122880&partnerID=MN8TOARS. 10.1371/journal.pone.0059104 Martinho, O.; Granja, S.; Jaraquemada, T.; Caeiro, C.; Miranda-Gonçalves, V.; Honavar, M.; Costa, P.; et al. "Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas". PLoS ONE 7 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856088642&partnerID=MN8TOARS. 10.1371/journal.pone.0030769 Silva-Correia, J.; Miranda-Gonçalves, V.; Salgado, A.J.; Sousa, N.; Oliveira, J.M.; Reis, R.M.; Reis, R.L.. "Angiogenic potential of gellan-gum-based hydrogels for application in nucleus pulposus regeneration: In vivo study". Tissue Engineering - Part A 18 11-12 (2012): 1203-1212. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861820964&partnerID=MN8TOARS. 10.1089/ten.tea.2011.0632 Pértega-Gomes, N.; Vizcaíno, J.R.; Miranda-Gonçalves, V.; Pinheiro, C.; Silva, J.; Pereira, H.; Monteiro, P.; et al. "Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer". BMC Cancer 11 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79960587072&partnerID=MN8TOARS. 10.1186/1471-2407-11-312
Capítulo de livro	Vera Miranda-Gonçalves; Catarina Guimarães-Teixeira; Rui Henrique; Carmen Jerónimo. "Metabolic regulation in urological tumors: interplay with epigenetics and epitranscriptomics". In Epigenetics and Metabolomics. Elsevier, 2021. Publicado Ana C. Fernandes; Cláudia Caeiro; Vera Miranda-Gonçalves; Fernanda Cury; Margarida Damasceno; Rui M. Reis; Olga Martinho. "Bevacizumab for Glioblastoma Treatment: Reviewing Biological and Clinical Hypothesis for its Success and Failures". In Anti-Angiogenesis Drug Discovery and Development, 175-226. BENTHAM SCIENCE PUBLISHERS, 2016. Publicado • 10.2174/9781681081557116030007 Céline Pinheiro; Filipa Morais-Santos; Sara Granja; Vera Miranda-Gonçalves; Julieta Afonso; Ricardo Amorim; Fátima Baltazar. "Targeting Metabolic Reprogramming as an Anti- Cancer Strategy: Aiming at Monocarboxylate Transporters". In Frontiers in Anti-Cancer Drug Discovery, 3-65. BENTHAM SCIENCE PUBLISHERS, 2015. Publicado • 10.2174/9781681081496115060003 Gonçalves, Vera Miranda; Baltazar, Fátima; Reis, Rui Manuel. "Brain Tumor Metabolism — Unraveling Its Role in Finding New Therapeutic Targets". In Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor. InTech, 2015. Publicado • 10.5772/59606
Poster em conferência	Carriço, Íris; Catarina Macedo-Silva; João A.M. Santos; Carmen Jerónimo; Vera Miranda-Gonçalves. "Epigenetic and Metabolic Insights in Prostate Cancer Radioresistance". Trabalho apresentado em 2nd Young Researchers Day, 2024. Fernandes-Pontes, Fernanda; Constâncio, Vera; Lobo, João; Henrique, Rui; Jerónimo, Carmen; Vera Miranda-Gonçalves. Autor correspondente: Vera Miranda-Gonçalves. "Uncovering the interplay between epigenetics and metabolism in sarcomatoid Renal Cell Carcinoma: A novel era for biomarkers". Trabalho apresentado em 2nd Young Researchers Day, 2024. Vera Miranda-Gonçalves; Carriço, Íris; Macedo-Silva, Catarina; Lencart, Joana; Henrique, Rui; Carmen Jerónimo. "EPIGENETIC INSIGHTS INTO PROSTATE CANCER RADIOTHERAPY: THERAPEUTIC INNOVATIONS FOR RADIOSENSITIZATION". Trabalho apresentado em RISE Day 2024, 2024. Oliveira-Sousa, Rúben; Carla Castro; Carriço, Íris; João A.M. Santos; Carmen Jerónimo; Vera Miranda-Gonçalves. "Impacto do horário do tratamento de radioterapia nos resultados oncológicos em pacientes com adenocarcinoma da próstata localizado: um estudo clínico observacional retrospetivo português". Trabalho apresentado em 6º ENCONTRO NACIONAL JOVENS INVESTIGADORES EM ONCOLOGIA - LPCC Norte, 2024. Angela Albuquerque-Castro; Vera Miranda-Gonçalves; Catarina Macedo-Silva; Angel Diaz-Lagares; Carmen Jerónimo. "A reprogramação metabólica como mecanismo de resistência à radioterapia em cancro da próstata: uma perspetiva epigenética". Trabalho apresentado em 6º ENCONTRO NACIONAL JOVENS INVESTIGADORES EM ONCOLOGIA - LPCC Norte, 2024. Carriço, Íris; Macedo-Silva, Catarina; João A.M. Santos; Carmen Jerónimo; Vera Miranda-Gonçalves. "Unravelling the Intricate Interplay Between Epigenetics and Metabolism to Overcome Radioresistance in Prostate Cancer". Trabalho apresentado em 48th European Radiation Research Society Meeting, 2024. Fernandes-Pontes, Fernanda; Constâncio, Vera; Jerónimo, Carmen; Henrique, Rui; Vera Miranda-Gonçalves. Autor correspondente: Vera Miranda-Gonçalves. "The interplay between epigenetics and metabolism in sarcomatoid Renal Cell Carcinoma: A novel era for biomarkers?". Trabalho apresentado em IPO Porto Summit, 2024. Macedo-Silva, Catarina; Angela Albuquerque-Castro; Lencart, Joana; Carneiro, Isa; Nuno Tiago Tavares; Barros-Silva, Daniela; João Lobo; et al. "Epigenetic reprogramming as Hallmark of prostate cancer radiobiology". Trabalho apresentado em Young Researchers Day IPO Porto, 2023. Vera Miranda-Gonçalves; Ana Lameirinhas; Beatriz Costa; Catarina Macedo-Silva; Paula C.Dias; Verónica Ferreira; Rui Silva-Santos; et al. "Metabolic-epigenetic landscape recoding in renal cell carcinoma: towards new therapeutic strategies". Trabalho apresentado em III ASPIC-ASEICA International Meeting: Cancer Immunology, Tumor Microenvironment & Metastasis, 2023. Macedo-Silva, Catarina; Vera Miranda-Gonçalves; Nuno Tiago Tavares; Barros-Silva, Daniela; Angela Albuquerque-Castro; Lencart, Joana; Carneiro, Isa; et al. "Epigenetic modulation of p53 by GSK-J4 attenuates prostate cancer radioresistance". Trabalho apresentado em ImmunoRad, 2023. Vera Miranda-Gonçalves; Catarina Guimarães-Teixeira; Ana Lameirinhas; João Lobo; Paula C.Dias; Verónica Ferreira; Henrique, Rui; Carmen Jeronimo. "Uncover a lactate - sirtuin 6 crosstalk in the metabolic reprogramming of renal cell carcinoma". Trabalho apresentado em Symposium on Cancer Genomics and Epitranscriptomics: from the bench to the clinic, 2022. Catarina Guimarães-Teixeira; Barros-Silva, Daniela; João Lobo; Silva-Santos, Rui; Henrique, Rui; Vera Miranda-Gonçalves; Carmen Jeronimo. Autor correspondente: Vera Miranda-Gonçalves. "N6-Methyladenosine RNA Modification and ts regulatory proteins in Renal Cell Carcinoma". Trabalho apresentado em Symposium on Cancer Genomics and Epitranscriptomics: from the bench to the clinic, 2022. Costa, Beatriz; João Lobo; Henrique, Rui; Carmen Jerónimo; Vera Miranda-Gonçalves. Autor correspondente: Vera Miranda-Gonçalves. "A inter-relação entre VHL e o perfil metabólico no carcinoma renal de células claras: MCTs e agressividade tumoral". Trabalho apresentado em 4º ENJIO edição, 2022. Vera Miranda-Gonçalves; Ana Lameirinhas; Catarina Macedo-Silva; João Lobo; Paula C.Dias; Verónica Ferreira; Henrique, Rui; Carmen Jeronimo. "Lactate – Sirtuin 6 axis mediating a metabolic reprogramming in renal cell carcinoma". Trabalho apresentado em 5th ASPIC International Congress, 2022. Catarina Macedo-Silva; Constâncio, Vera; Vera Miranda-Gonçalves; Leite-Silva, Pedro; Salta, Sofia; João Lobo; Rita Guimarães; et al. "DNA methylation biomarkers to residual disease detection in esophageal cancer upon neoadjuvant chemoradiation.". Trabalho apresentado em 5th ASPIC International congress, 2022. Catarina Macedo-Silva; Oriana Ribeiro; Nuno Tiago Tavares; Vera Miranda-Gonçalves; Lencart, Joana; Rosário Benedetti; Correia, Margareta P; Lucia Atucci; Carmen Jeronimo. "Epigenetically-induced TP53 in radioresistante prostate cancer model: a new radiosensitizing strategy". Trabalho apresentado em EACR Congress - Innovative Cancer Science: Translating Biology to Medicine, 2022. Macedo-Silva, Catarina; Oriana Ribeiro; Nuno Tiago Tavares; Vera Miranda-Gonçalves; Joana Lencart; Sofia Silva; Benedetti, Rosaria; et al. "Epigenetically-induced TP53 in radioresistant prostate cancer model: A new radiosensitizing strategy.". Trabalho apresentado em EACR 2022 Congress ¿ Innovative Cancer Science: Translating Biology to Medicine., 2022. Filipa Amaro.; Carolina Pisoeiro; Maria João Valente; Vera Miranda-Gonçalves; Carmen Jerónimo; Rui Henrique; Maria de Lourdes Bastos; et al. "In vitro metabolic response of renal cell carcinoma and non-tumorigenic cells to tyrosine kinase inhibitors". Trabalho apresentado em Metabolomics 2022: the 18th Annual Conference of Metabolomics Society, Valencia, 19 a 23 junho de 202, 2022. Filipa Amaro; Carolina Pisoeiro; Maria João Valente; Vera Miranda-Gonçalves; , Carmen Jerónimo, Rui Henrique, Maria de Lourdes Bastos, Paula Guedes de Pinho, Márcia Carvalho, Joana Pinto. "Differential cellular effects of sunitinib and pazopanib targeted drugs for metastatic renal cell carcinoma ¿ an in vitro approach". Trabalho apresentado em APCF-TOXRUN, 2022. Vera Miranda-Gonçalves; João Lobo; Catarina Guimarães-Teixeira; Daniela Barros-Silva; Rita Guimarães; Mariana Cantante; Isaac Braga; et al. "The role of m6A methyltransferase VIRMA in testicular germ cell tumors aggressivness and cisplatin response". Trabalho apresentado em II ASPIC-ASEICA International Meeting: Current trends of precision medicine in cancer, 2021. Cláudia Martins-Lima; Lobo, João; Constâncio, Vera; Catarina Guimarães-Teixeira; Vera Miranda-Gonçalves; Monteiro-Reis, Sara; Ana Lameirinhas; et al. "EMT impact in bladder cancer progression: understanding the cadherins´ role and their regulatory mechanisms". Trabalho apresentado em Porto Cancer Meeting, 2021. Vera Miranda-Gonçalves; Ana Lameirinhas; João Lobo; Paula C. Dias; Verónica Ferreira; Rui Henrique; Carmen Jerónimo. "Role of lactate on sirtuin 1 modulation: an interplay in renal cell carcinoma aggressiveness". Trabalho apresentado em EACR-AACR-ASPIC Conference: Tumor Microenvironment, 2020. Filipa Quintela Vieira; Ângela Marques-Magalhães; Vera Miranda-Gonçalves; Ricardo Ferraz; Cristina Prudêncio; Carmen Jerónimo; Regina Augusta Silva. "Molecular impact of [C16Pyr][Amp] treatment on breast and prostate cancer cell lines". Trabalho apresentado em P.PORTO Research Workshops, 2019. Vera Miranda-Gonçalves; Ana Lameirinhas; Catarina Macedo-Silva; Rui Henrique; Carmen Jerónimo. "Lactate in renal cell carcinoma progression: modulation of epigenetic landscape". Trabalho apresentado em Epigenetics & Chromatin - Cold Spring Harbor Laboratory, 2018. Catarina Macedo-Silva; Vera Miranda-Gonçalves; Joana Lencart; Sofia Silva; Ana Lameirinhas; Rui Henrique; Isabel Bravo; Carmen Jerónimo. "Esophageal cancer therapy response: role of hypoxia in epigenetic mechanism regulation". Trabalho apresentado em ASPIC International Congress, 2018. Vera Miranda-Gonçalves; Ana lameirinhas; Catarina Macedo-Silva; Rui Henrique; Carmen Jerónimo. "Lactate modulates epigenetic mechanisms contributing to kidney cancer progression". Trabalho apresentado em ASPIC International Congress, 2018. Sara Monteiro-Reis; Ana Lameirinhas; Vera Miranda-Gonçalves; Diana Montezuma-Felizardo; Paula C. Dias; Jorge Oliveira; Inês Graça; Rui Henrique; Carmen Jerónimo. "Role of SIRT7 in invasive high grade bladder cancer". Trabalho apresentado em Epigenetics & Chromatin Cold Spring Harbor Laboratory, 2018. Vera Miranda-Gonçalves; Diana Cardoso-Carneiro; Inês Valbom; Fernanda Cury; Viviane Aline; Sara Granja; Fátima Baltazar; Rui Manuel Vieira Reis; Olga Catarina Lopes Martinho. "Understanding the cellular metabolic reprogramming associated with bevacizumab therapy in glioblastoma". Trabalho apresentado em ICVS Open day, 2017. Olga Martinho; Renato Silva-Oliveira; Fernanda Cury; Ana Martins Barbosa; Sara Granja; Adriane Feijó Evangelista; Fábio Marques; et al. "Blocking glucose metabolism enhances the effect of HER inhibitors in cervical cancer therapy". Trabalho apresentado em XIX Congresso Nacional da Sociedade Portuguesa de Bioquímica, Guimarãres (Portugal), 2016. Olga Martinho; Renato Silva-Oliveira; Fernanda Cury; Ana Martins Barbosa; Sara Granja; Fábio Marques; Vera Miranda-Gonçalves; et al. "HER receptors are important theranostic biomarkers on cervical cancer: blocking glucose metabolism enhances the therapeutic effect of HER inhibitors.". Trabalho apresentado em 16th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2016), 2016. Vera Miranda-Gonçalves; Filipa Berreza; Raquel Costa-Almeida; Marta Freitas-Cunha; Raquel Soares; Olga Martinho; Rui M. Reis; Céline Pinheiro; Fátima Baltazar. "Monocarboxylate Transporter 1 is an important player in tumor endothelial cell crosstalk in glioblastomas". Trabalho apresentado em ISCaM: Metabolic Network in Cancer, 2016. Vera Miranda-Gonçalves; Mrinalini Honavar; Manuel M. Pires; Célia Pinheiro; Michelle Cordeiro; Gil Bebiano; Paulo Costa; Rui M. Reis; Baltazar, F. "Monocarboxylate Transporter 1 (MCT1) expression at hypoxic conditions in glioblastomas: functional role and regulation". Trabalho apresentado em XXIII Porto Cancer Meeting - Stem Cells and Cancer, 2015. Filipa Morais-Santos; Sara Granja; Vera Miranda-Gonçalves; António H.J. Moreira; João L. Vilaça; Joana Paredes; Fernando C. Schmitt; Baltazar, F; Céline Pinheiro. "Targeting lactate transport suppresses in vivo breast tumor growth". Trabalho apresentado em XXIII Porto Cancer Meeting - Stem Cells and Cancer, 2015. Vera Miranda-Gonçalves; Ribeiro V. P.; Silva-Correia J.; Yan L. P.; Oliveira A.L.; Reis R.M.; Reis R.L.; Oliveira J.M.. "Novel Enzymatically Cross-linked Silk Fibroin Hydrogel with potential applications as supressor of angiogenesis and tumor progression". Trabalho apresentado em ESB - 27th European Conferenceon Biomaterials, 2015. Vera Miranda-Gonçalves; Mrinalini Honavar; Manuel M. Pires; Célia Pinheiro; Michelle Cordeiro; Gil Bebiano; Paulo Costa; Rui M. Reis; Fátima Baltazar. "MCT1 plasma membrae expression at hypoxic regions could be a mediator of cellular aggressiveness in glioblastomas". Trabalho apresentado em Stem cell and Cancer - XXIII Porto Cancer Meeting, 2015. Silva-Carvalho, Ricardo; Vera Miranda-Gonçalves; Ferreira, AM; Cardoso, Susana M.; Abilio J. F. N. Sobral; Almeida-Aguiar, Cristina. "Characterization of antitumor and antiangiogenic properties of Pereiro Propolis". Trabalho apresentado em 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 2014. Silva-Carvalho, Ricardo; Vera Miranda-Gonçalves; Ferreira, AM; Cardoso, Susana M.; Sobral, Abílio JFN; Almeida-Aguiar, Cristina; Baltazar, Fatima. "Characterization of the antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models". Trabalho apresentado em 3rd Iberian conference of Apiculture, Mirandela, Portugal, 2014. Vera Miranda-Gonçalves; Mrinalini Honavar; Rui M. Reis; Fátima Baltazar. "Involvemetn of Monocarboxylate Transporter 1 (MCT1) in glioblastoma aggressiveness". Trabalho apresentado em 1st ASPIC International Congress, 2014. Vera Miranda-Gonçalves; Mrinalini Honavar; Rui M. Reis; Fátima Baltazar. "Involvement of MCT1 at hypoxic regions in aggressiveness of glioblastomas". Trabalho apresentado em IV Simpósio Internacional de Oncologia Translational do Hospital de Câncer de Barretos, 2014. Vera Miranda-Gonçalves; Mrinalini Honavar; Rui M. Reis; Fátima Baltazar. "Involvement of Monocarboxylate Transporter 1 (MCT1) in glioblastoma aggressiveness". Trabalho apresentado em ESPCA: Oncogenesis and Translational Medicine for Cancer Therapy, 2014. Vera Miranda-Gonçalves; Mrinalini Honavar; Manuel M. Pires; Célia Pinheiro; Michelle Cordeiro; Gil Bebiano; Paulo Costa; Rui M. Reis; Fátima Baltazar. "MCT1 plasma membrane expression at hypoxic regions could be a mediator of celullar aggressiveness in glioblastomas". Trabalho apresentado em Congresso Nacional da Associação Portuguesa de Neuro-Oncologia (APNO), 2013. Filipa Bezerra; Marta Freitas-Cunha; Vera Miranda-Gonçalves; Céline Pinheiro; Fátima Baltazar. "Monocarboxylate transporters as a mediator in tumor-endothelial crosstalk". Trabalho apresentado em XXII Porto Cancer Meeting, 2013. Susana Sousa; Vera Miranda-Gonçalves; Nelma Pétrega-Gomes; José Ramón Vizcaíno; Carmen Jerónimo; Carlos Lopes; Fátima Baltazar; Rui Henrique. "The effect of MCT1 and MCT4 downregulation on prostate cancer survival and aggressiveness". Trabalho apresentado em XXII Porto Cancer Meeting, 2013. Julieta Afonso; Adhemar Longatto-Filho; Vera Miranda-Gonçalves; Nuno Sousa; António Morais; Teresina Amaro; Lúcio L. Santos; Fátima Baltazar. "CD147 and MCT1-Potential partners in bladder cancer aggressiveness and chemoressitance". Trabalho apresentado em XXII Porto Cancer Meeting, 2013. Vera Miranda-Gonçalves; Mrinalini Honavar; Céline Pinheiro; Olga Martinho; Rui M. Reis; Fátima Baltazar. "MCT1 plasma membrane expression is associated to hypoxic regions in glioblastomas". Trabalho apresentado em EACR22 - from Basic Research to Personalized Cancer Treatment, 2012. Vera Miranda-Gonçalves; Mrinalini Honavar; Céline Pinheiro; Olga Martinho; Michelle Cordeiro; Gil Bebiano; Paulo Costa; Rui M. Reis; Fátima Baltazar. "Hypoxia induce MCT1 plasma membrane expression in glioblastomas". Trabalho apresentado em XXI Porto Cancer Meeting: Metabolism and Cancer from Etiophatogenesis to Therapy, 2012. Vera Miranda-Gonçalves; Mrinalini Honavar; Céline Pinheiro; Olga Martinho; Paulo Costa; Rui M. Reis; Fátima Baltazar. "Targeting lactate transport in glioblastomas". Trabalho apresentado em 2nd Symposium of the International Society of Proton and Dynamics in Cancer (ISPDC), 2011. Vera Miranda-Gonçalves; Nelma Pétrega-Gomes; Tatiana Lourenço; Céline Pinheiro; Carmen Jerónimo; José Ramón Vizcaíno; Carlos Lopes; Fátima Baltazar. "Prostate Cancer: exploitation of monocarboxylate transporters as potential therapeutic targets". Trabalho apresentado em 39th Meeting of International Society of Oncology and Biomarkers (ISOBM), 2011. Vera Miranda-Gonçalves; Mrinalini Honavar; Céline Pinheiro; Olga Martinho; Paulo Costa; Rui M. Reis; Fátima Baltazar. "Monocarboxylate transporters as potential therapeutic target in glioblastomas". Trabalho apresentado em XX Porto Cancer Meeting - Drug Resistance in cancer: From biology to molecular targets and drugs, 2011. Marta Pojo; Tiago Gonçalves; Joana Cunha; Bernardo Gama; Vera Miranda-Gonçalves; Rui M. Reis; Bruno M Costa. "Influence of HOXA9 expression in the response of glioblastomas cell to Temozolomide". Trabalho apresentado em XX Porto Cancer Meeting - Drug Resistance: from biology to molecular targets and drugs, 2011. Vera Miranda-Gonçalves; Silva- Correia J.; Oliveira J.M.; Rui M. Reis; Rui L. Reis. "Methacrylated gellan gum hydrogels for application in nucleus pulposus regeneration: in vitro and in vivo studies". Trabalho apresentado em 24th European Conference on Biomaterials, 2011. Vera Miranda-Gonçalves; Céline Pinheiro; Mrinalini Honavar; Paulo Costa; Fátima Baltazar; Rui M. Reis. "Upregulation of MCT1 and its chaperone CD147 in glioblastomas". Trabalho apresentado em XIX Porto Cancer Meeting - Differentiation, Regeneration and Cancer, 2010. Céline Pinheiro; Silvia Pinheiro; Vera Miranda-Gonçalves; André Vieira; Joana Paredes; Fernando Schmitt; Fátima Baltazar. "Sensitivity of breast cancer cells to CHC, an inhibitor of monocarboxylate transporter 1". Trabalho apresentado em XIX Porto Cancer Meeting - Differentiation, Regeneration and Cancer, 2010. Vera Miranda-Gonçalves; Nelma Pétrega-Gomes; Céline Pinheiro; José Ramón Vizcaíno; Carlos Lopes; Fátima Baltazar. "Monocarboxylate Transporter 2 as a putative prostate cancer marker". Trabalho apresentado em XIX Porto Cancer Meeting - Differentiation, Regeneration and Cancer, 2010. Vera Miranda-Gonçalves; Céline Pinheiro; Honavar, Mrinalini; Paulo Costa; Fátima Baltazar; Rui M. Reis. "Therapeutic potential of MCT inhibitors in glioblastoma". Trabalho apresentado em 2º National Congress of Neuro-Oncology Portuguese Association, 2009.
Tese / Dissertação	Baltazar, Fátima; Reis, R. M.; Gonçalves, Vera Mónica Miranda. "Monocarboxylate Transporters in gliomas: regulation and therapeutic implications". Doutoramento, 2016. http://hdl.handle.net/1822/45259. Baltazar, Fátima; Reis, R. M.; Gonçalves, Vera Mónica Miranda. "Role of monocarboxylate transporters in the metabolic remodelling of glioblastomas". Mestrado, Universidade do Minho Escola de Medicina, 2012. http://hdl.handle.net/1822/24445.

Outros

Outra produção

Tumor growth suppression induced by biomimetic silk fibroin hydrogels. Protein-based hydrogels with distinct conformations which enable encapsulation or differentiation of cells are of great interest in 3D cancer research models. Conformational changes may cause macroscopic shifts in the hydrogels, allowing for its use as biosensors and drug carriers. In depth knowledge on how 3D conformational changes in proteins may affect cell fate and tumor formation is required.. 2016. Leping, Yan; Silva-Correia, Joana; Ribeiro, Viviana Pinto; Gonçalves, Vera Mónica Miranda; Correia, Cristina; Morais, Alain José Silva; Sousa, Rui A.; et al. http://hdl.handle.net/1822/42482.
10.1038/srep31037
Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells. Cancer cells rely mostly on glycolysis to meet their energetic demands, producing large amounts of lactate that are extruded to the tumour microenvironment by monocarboxylate transporters (MCTs). The role of MCTs in the survival of colorectal cancer (CRC) cells is scarce and poorly understood. In this study, we aimed to better understand this issue and exploit these transporters as novel therapeut. 2015. Amorim, Ricardo; Pinheiro, Céline; Gonçalves, Vera Mónica Miranda; Pereira, Helena; Moyer, Mary P.; Preto, Ana; Baltazar, Fátima. http://hdl.handle.net/1822/40241.
10.1016/j.canlet.2015.05.015
Targeting lactate transport suppresses in vivo breast tumour growth. Background: Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as “Warburg effect”. Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with higher cell proliferation, migration, invasion, angiogenesis and increased cell survival. Previously, we. 2015. Morais-Santos, Filipa; Granja, Sara; Miranda-Gonçalves, Vera; Moreira, António H.J.; Queirós, Sandro; Vilaça, João L.; Schmitt, Fernando C.; et al. http://hdl.handle.net/11110/997.
Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models. Propolis, a natural product, has important biological properties, however, studies with Portuguese propolis are scarce. Thus, we aimed to characterize the chemical composition and the antitumoural and antiangiogenic activities of a sample from Pereiro (Portugal). The chemical profile of our propolis sample (P10.EE) is similar to the poplar propolis type. P10.EE decreased cell viability of differen. 2014. Carvalho, Ricardo Silva; Gonçalves, Vera Mónica Miranda; Ferreira, Ana Margarida; Cardoso, Susana M.; Sobral, Abílio J. F. N.; Aguiar, Cristina; Baltazar, Fátima. http://hdl.handle.net/1822/31677.
10.1016/j.jff.2014.09.009
Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro. Propolis is a resin collected by bees from plant buds and exudates, which is further processed through the activity of bee enzymes. Propolis has been shown to possess many biological and pharmacological properties, such as antimicrobial, antioxidant, immunostimulant and antitumor activities. Due to this bioactivity profile, this resin can become an alternative, economic and safe source of natural. 2013. Santos, Luísa Filipa Morais dos; Gonçalves, Vera Mónica Miranda; Baltazar, Fátima; Valença, Isabel; Ferreira, Ana Margarida; Aguiar, Cristina. http://hdl.handle.net/1822/28150.
10.1186/1472-6882-13-184

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/09/10	Unveiling the circadian rhythm's influence on prostate cancer radiotherapy response	48th European Radiation Research Society Meeting (Aveiro, Portugal)
2024/05/09	Epigenetic Radiosensitizing Approaches in Prostate Cancer Therapy: Bridging Bench to Bedside	IPO PORTO SUMMIT Portuguese Oncology Institute of Porto (IPO-Porto) (Porto, Portugal)
2024/04/29	Lactate in the epigenetic landscape recoding: towards new therapeutic strategies in renal cell carcinoma.	6th ASPIC International Congress ASPIC (Faro, Portugal)
2023/11/09	Decoding the Metabolic-Epigenetic Rewiring in Renal Cell Carcinoma: Towards New Therapeutic Strategies	1st Young Researchers Day Portuguese Oncology Institute of Porto (IPO-Porto) (Porto, Portugal)
2021/09/21	Unraveling the role of m6A writer complex VIRMA in Germ Cell Tumors progression	EPITRAN European Epitranscriptomics Network COST European Cooperation in Sciences & Technology (Trento, Itália)
2019/10	Metabolic reprogramming and epigenetic landscape: an interplay to renal cell carcinoma aggressiveness promotion	The 26th Meeting of the EAU Section of Urological Research (ESUR) (Porto, Portugal)
2019/10	Epigenetic-Metabolic interplay in renal cell carcinoma: role of lactate on sirtuin’s modulation	ISCaM2019, 6th Anual Meeting: Cancer Metabolic Rewiring International Society of Cancer Metabolism (ISCaM) (Braga, Portugal)
2019	Impact of lactate exposure in renal cell carcinoma aggressiveness: role of sirtuin's modulation	12º edição do IJUP (Porto, Portugal)
2019	Role of JmjC-KDMs in HIF-1alpha-dependent modulation: Effect on esophageal squamous cell carcinoma radioresistance	12º edição IJUP (Porto, Portugal)
2016	Monocarboxylate transporter 1 (MCT1) in glioblastoma: prognostic value and exploitation as therapeutic target	XIX National Congress of Biochemistry (Guimarães, Portugal)
2015	MCT1 plasma membrane expression as a mediator of cellular aggressiveness at hypoxic regions inglioblastomas	2nd ISCaM meeting- Metabolism and Microenvironment in cancer plasticity International Society of Cancer Metabolism (ISCaM) (Venice, Itália)
2013	Development of Anatomical Silk/Methacrylated Gellan Gum Scaffolds for Controlling Segmental Vascularization in Meniscus Tissue Regeneration	TERMIS-EU (Istanbul, Turquia)
2013	Novel Silk-based Scaffolds for Meniscus Tissue Engineering: The Relevance of Controlling Segmental Vascularization by Methacrylated Gellan gum Hydrogels	14th EFORT Congress (Istanbul, Turquia)
2012	Novas matrizes de seda para Engenharia de Tecidos do Menisco: A importância do controlo da neovascularização com Hidrogéis de Goma Gelana Metacrilada	XXXII Congress of the Portuguese Society of Orthopaedics and Traumatology (Vila Moura, Portugal)
2012	Functionalized gellan gum hydrogels for intervertebral disc regeneration: In vitro and in vivo studies	9th World Biomaterials Congress (Chengdu, China)
2011	Effectiveness of receptor tyrosine kinase (RTKs) targeted therapies in glioblastomas	International Society of Oncology and Biomarkers (ISOBM) (Florence, Itália)
2009	Prostate Cancer: Metabolism and Monocarboxylate transporters (MCTs)	IV Young European Scientist Meeting (Porto, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2023/12 - Atual	Probing the Molecular Interplay of Epigenetics and Metabolism to Overcome Radioresistance in Prostate Cancer Orientador	PhD in Pathology and Molecular Genetics (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09 - Atual	The interplay between epigenetics and metabolism in sarcomatoid Renal Cell Carcinoma: A novel era for biomarkers? Orientador	MSc in Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09 - Atual	CIRCA-PREDICT: Epigenetic Insights into Chronotype-Integrated Radiotherapy for Prostate CAncer - PREDICting the Impact on Efficacy and Toxicity of Treatment Timing with Circadian Rhythms Orientador	MSc in Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09 - Atual	Epitranscriptomic alterations within renal cancer metabolism reprogramming: uncovering new therapeutic targets Coorientador	Pathology and Molecular Genetics (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - 2022	The Role of VHL/HIF axis-dependent metabolic profile in clear cell renal cell carcinoma aggressiveness Orientador	Master in Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/09 - 2020/11	Anti-neoplastic effect of MLo1302 in Testicular Germ Cell Tumors: comparison with classical differentiating and demethylating agents, ATRA and DAC Coorientador	Master In Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/03 - 2020/06	Metabolic characterization of testicular tumours: a role of epigenetic landscape Orientador	Curricular traineeship in Biochemistry (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2017 - 2018	Interplay between Warburg effect and epigenetic mechanisms in kidney cancer Coorientador	Master in Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2018	Esophageal cancer therapy response: role of hypoxia in epigenetic mechanism regulation Coorientador	Master in Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2018	Monocarboxylate Transporters (MCTs) in kidney cancer: the role of epigenetic mechanisms Coorientador	Master in oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2015	Metabolic alterations in bevacizumab treated glioblastoma cells Coorientador	Curricular traineeship in Biochemistry (Licenciatura/Bacharelato) Universidade do Minho Escola de Ciências, Portugal
2014 - 2014	Characterization of glycolytic metabolic protein expressions in melanomas Coorientador	Integrated Master in Medicine (Mestrado) Universidade do Minho Escola de Medicina, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/12/09	BIOFABRICATION OF 3D TUMOR MODELS FOR IN VITRO SCREENING OF THERAPEUTICS Arguente	Inês Margarida Curioso Freitas (Mestrado) Universidade de Aveiro, Portugal
2024/11/15	"Biomarcadores de prognóstico e potenciais alvos terapêuticos no carcinoma epidermóide da orofaringe" Arguente	Ana Isabel Pereira Rodrigues (Mestrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/12	Dissecting the roles of the Aryl Hydrocarbon Receptor from a sensor to a regulator of the melanoma microenvironment Arguente principal	Beatriz Gandra Moreira (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/07	O papel da CD147 na imunossupressão tumoral Arguente principal	Ana Teresa Moreira Leal (Outro) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/12/09	The role of hypoxia on immunomodulation at the colon cancer microenvironment Arguente principal	Ana Rita Fialho dos Santos (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/11/29	O papel do GPR81 no cancro de pulmão de não pequenas células Arguente principal	Ana Margarida Ribeiro Silva (Mestrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/11/25	Estudo do Efeito da Berberina em Cancro da Próstata: o Papel da SMYD3 Arguente principal	Maria João Ribeiro Oliveria (Mestrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2022/11/25	The role of VHL/HIF axis-dependent metabolic profile in clear cell renal cell carcinoma aggressiveness Orientador	Ana Beatriz Ferreira Costa (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/02/16	GPR81 in Bladder Cancer - Functional Insights Arguente principal	Ana Mafalda Azevedo Félix (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2021/03	Embryonic T-box transcription factor Brachyury as a predictive biomarker and therapeutic target in prostate and lung cancer Arguente principal	Patricia Fernandes Fontão (Mestrado) Universidade do Minho Escola de Ciências, Portugal
2019/12/16	Prostate cancer cells metabolism on the interplay of androgenic regulation and metabolic environment Arguente	Henrique José Matos Morão Mingote Cardoso (Doutoramento) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018	Interplay between Warburg effect and epigenetic mechanisms in kidney cancer Orientador	Ana Lameirinhas (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2024/10 - 2024/11	Lecture " CAM assay" from curricular unit Experimental Cancerization from MSc program in Oncology	(Mestrado)	Universidade do Porto Faculdade de Medicina, Portugal
2024/10 - 2024/11	Lecture “In vivo experimental models: chicken chorioallantoic membrane (CAM) assay”, curricular unit Oncobiology, MSc in Biochemistry and MSc in Bioengineering of Faculty of Sciences, University of Porto (FCUP) and Faculty of Engineering, University of Porto (FEUP)	MSc in Biochemistry/ MSc in Bioengineering (Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Faculdade de Engenharia, Portugal
2023/10 - 2024/10	Lecture Class "Epigenetics & Cancer Metabolism", curricular unit Epigenetics from MSc in Oncology	MSc in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/05 - 2024/05	“Confocal Microscopy: 3D reconstruction imaging” and “In vitro and In vivo Experimental Models of Radiotherapy”, Curricular Unit Research Practices in Oncology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP).	MSc in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/10 - 2023/10	Lecture "Fundamentals of Chicken Chorioallantoic Membrane (CAM) Assay" of curricular unit Experimental Cancerization from MSc program in Oncology	MSc in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/03/27 - 2023/07/28	Oncobiology	Medicinal Biotechnology (Licenciatura)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/03/27 - 2023/07/28	Oncobiology	Biomedical Laboratory Sciences (Licenciatura)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023/04 - 2023/04	Lecture Class "Epigenetics & Cancer Metabolism", curricular unit Epigenetics from MSc in Oncology	MSc in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/03 - 2023/03	Lecture classe on" Epigenetics and cancer Metabolism" of curricular unit Cancer Epigenetics from PhD/MSc program in Medicine and Molecular Oncology and PhD program in Pathology & molecular Genetics	MSc In Medicine and Molecular Oncology (Mestrado)	Universidade do Porto Faculdade de Medicina, Portugal
2022/04 - 2022/04	Lecture Class "Epigenetics & Cancer Metabolism", curricular unit Epigenetics from MSc in Oncology	MSc in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/02/07 - 2022/02/07	Lecture classe on" Epigenetics and cancer Metabolism" of curricular unit Cancer Epigenetics from PhD/MSc program in Medicine and Molecular Oncology and PhD program in Pathology & molecular Genetics	Master in Medicine and Molecular Oncology (Mestrado)	Universidade do Porto Faculdade de Medicina, Portugal
2022 - 2022	Lecture "Fundamentals of Chicken Chorioallantoic Membrane (CAM) Assay" of curricular unit Experimental Cancerization from MSc program in Oncology	MSc in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/10/28 - 2021/10/28	Lecture "Fundamentals of Chicken Chorioallantoic Membrane (CAM) Assay" of curricular unit Experimental Cancerization from MSc program in Oncology	Master Degree in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/04/27 - 2021/04/27	Lecture classe on" Epigenetics and cancer Metabolism" of curricular unit Epigenetics from MSc program in Oncology	Master Degree in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/02/08 - 2021/02/08	Lecture classe on" Epigenetics and cancer Metabolism" of curricular unit Cancer Epigenetics from PhD/MSc program in Medicine and Molecular Oncology and PhD program in Pathology & molecular Genetics	MSc in Medicine and Molecular Oncology (Mestrado)	Universidade do Porto Faculdade de Medicina, Portugal
2020/11/03 - 2020/11/24	Lecture "Fundamentals of Chicken Chorioallantoic Membrane (CAM) Assay" of curricular unit Experimental Cancerization from MSc program in Oncology	Master in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/11 - 2020/11	Lecture "Cell culture" class in Introduction to Research Activity CI-IPOP Training Course	(Outros)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2020/02/03 - 2020/02/20	Lecture classe on" Epigenetics and cancer Metabolism" of curricular unit Cancer Epigenetics from PhD/MSc program in Medicine and Molecular Oncology and PhD program in Pathology & molecular Genetics	MSc in Medicine and Molecular Oncology (Mestrado)
2019/10/21 - 2019/11/01	Co-organization and Lecture of Basic cell culture course, 5th edition	Basic course of cell culture (Outros)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2019/09/17 - 2019/10/17	Lecture "Cell culture" class in Introduction to Research Activity CI-IPOP Training Course	(Outros)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2019 - 2019	Lecture classe on" Epigenetics and cancer Metabolism" of curricular unit Cancer Epigenetics from PhD/MSc program in Medicine and Molecular Oncology and PhD program in Pathology & molecular Genetics	(Outros)	Universidade do Porto, Portugal
2019 - 2019	Lecture in "Epigenetics and Cancer Metabolism" of curricular unit Epigenetics	Master in Oncology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/10/01 - 2018/10/13	Co-organization and Lecture of Basic cell culture course, 4th edition	Basic course of cell culture (Outros)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2018 - 2018	Lecture classe on "Epigenetics and Cancer Metabolism" of curricular unit Cancer Epigenetics from PhD/MSc program in Medicine and Molecular Oncology	(Outros)	Universidade do Porto Faculdade de Medicina, Portugal
2017/09/04 - 2017/09/09	Co-organization and Lecture of Basic cell culture course, 3rd edition	Basic course of cell culture (Outros)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2017/05/08 - 2017/05/20	Co-organization and Lecture of Basic cell culture course, 2nd edition	Basic course of cell culture (Outros)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2015/11/09 - 2015/11/20	Lecture of pratical classes in Fundamentals in Genetic, Development and Neoplasia course, 7th edition	(Mestrado)	Universidade do Minho Escola de Medicina, Portugal
2014/10/13 - 2014/10/20	Lecture of pratical classes in Fundamentals in Genetic, Development and Neoplasia course, 6th edition	(Mestrado)	Universidade do Minho Escola de Medicina, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2014 - Atual	Portuguese Association of Cancer Research (ASPIC)
2014 - Atual	European Association for Cancer Research (EACR)
2011 - Atual	International Society for Cancer Metabolism (ISCaM)
2010 - Atual	Sociedade Portuguesa de Bioquimica
2009 - Atual	Neuro-Oncology Portuguese Association (APNO)

Revisão ad hoc de artigos em revista

	Nome da revista (ISSN)	Editora
2021 - Atual	Journal of Translational Medicine	BMC journal
2019 - Atual	Clinical Epigenetics	BMC Journal
2019 - Atual	Theranostics
2019 - Atual	Cancers	MDPI

Tutoria

	Tópico	Nome do aluno
2023/03 - 2023/06	Tumor metabolism and prostate cancer radioresistance	Rúben Diogo Oliveira de Sousa
2023/03 - 2023/06	Sarcomatoid methylation profile	Fernanda Pontes
2021/02/22 - 2021/06/23	Laboratory Practice / Clinical Practice of the Master's Degree in Oncology	Ana Beatriz Ferreira Costa
2019/02/11 - 2019/06/07	Laboratory Practice / Clinical Practice of the Master's Degree in Oncology	Ana Rita Cardoso

Distinções

Prémio

2024	2º award in a poster presentation, “Impacto do horário do tratamento de radioterapia nos resultados oncológicos em pacientes com adenocarcinoma da próstata localizado: um estudo clínico observacional retrospetivo português". Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2024	1º award in oral communication, “Reprogramação metabólica e ativação imunológica no carcinoma renal: papel do FTO e potencial terapêutico do inibidor DAC51” Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2023	1º award in a poster presentation: "Epigenetic reprogramming as Hallmark of prostate cancer radiobiology". Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2017	Prémio Professor Manuel Teixeira Silva Universidade do Minho Escola de Medicina, Portugal
2009	2º award in oral communication : "Prostate Cancer: Metabolism and Monocarboxylate Transporters (MCTs)" IV Young European Scientist Meeting, Portugal