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Currently, I am a Research Group Leader at the University Hospital at Tübingen, and I am leading the team of “Hyperpolarized Metabolism and Molecular Imaging”. I have supervised/trained/mentored several high-school, undergraduate and graduate students. So far, my scientific work has produced 36 publications in scientific international journals as well as some prestigious awards. The research interest of my group is directed towards understanding the physicochemical, biochemical and biological properties of the next generation of non-invasive metabolic sensors for application in translational biomedical and clinical sciences. We wish to translate new technology in vivo and validate imaging biomarkers relevant to severe abnormal metabolic diseases as, cancer senescence, diabetes, neurodegeneration, cirrhosis, inflammation, and kidney failure. The multidisciplinary research of our lab combines advanced multimodal, multiparametric and, state-of-art hybrid imaging that allows for accurate detection of disease and predict response to personalized therapies. Research topics: 1) Multimodal/Hybrid Imaging of the microenvironment & immunotherapy 2) Hyperpolarized metabolism and metallomics 3) Functional quantitative imaging (next generation of imaging agents) 4) Metabolic profiling & aggressiveness
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Identificação

Identificação pessoal

Nome completo
Andre Ferreira Martins

Nomes de citação

  • Martins, Andre F.
  • Andre F. Martins
  • AF Martins

Identificadores de autor

Ciência ID
931F-8493-9C96
ORCID iD
0000-0002-0171-0261

Endereços de correio eletrónico

  • andre.martins@med.uni-tuebingen.de (Profissional)

Websites

  • http://www.isct.uni-tuebingen.de/wsic/group/staff/staff-member/andre-martins/ (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Radiologia, Medicina Nuclear e Imagens Médicas
  • Ciências Exatas - Química - Química Inorgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Francês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador independente (B1)
Alemão Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2009 - 2013/11/11
Em curso
 Bioquimica / Quimica (Doutoramento)
Universidade de Coimbra, Portugal
"Targeted Multimodal Imaging Agents for the Detection of Aß Plaques in Alzheimer’s Disease" (TESE/DISSERTAÇÃO)
2009 - 2009
Concluído
 Quimica (Mestrado)
Centre National de la Recherche Scientifique, França
"Gadolinium based contrast agents" (TESE/DISSERTAÇÃO)
 16.2
2003 - 2008
Concluído
 Bioquimica (Licenciatura)
Universidade de Coimbra, Portugal
"Gadolinium based contrast agents" (TESE/DISSERTAÇÃO)
 16.2
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/04 - Atual Investigador principal (carreira) (Investigação) Eberhard Karls Universität Tübingen, Alemanha
Werner Siemens Imaging Center, Alemanha
(...)
Projetos

Bolsa

Designação Financiadores
2020/06/01 - Atual PET/MR Imaging of Macrophage Responses to Radiation and Immunotherapy
n/a
Investigador responsável
Stanford University Department of Radiology
Em curso
2018/09/01 - 2023/08/30 Imaging glucose-stimulated zinc secretion (GSZS) from the prostate by MRI: A potentially powerful method for early detection of prostate cancer
RP180178
Outra
Cancer Prevention and Research Institute of Texas, Estados Unidos
 Cancer Prevention and Research Institute of Texas
Em curso
2012/09/19 - 2023/08 Imaging beta cell function in vivo with a Zinc responsive MRI contrast agent
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES/4R01DK095416-05/US
National Institute of Diabetes and Digestive and Kidney Diseases, Estados Unidos
 National Institutes of Health
Em curso
2020/02/01 - 2023/01/31 Towards Metabolic Profiling of Tumours in vivo
NWG_UKT_AnFM
Investigador responsável
Eberhard Karls Universität Tübingen, Alemanha
 Eberhard Karls Universität Tübingen
Em curso
Produções

Publicações

Artigo em revista
  1. Veronica Clavijo Jordan; Alia Al-Ebraheem; Kalotina Geraki; Erica Dao; Andre F. Martins; Sara Chirayil; Michael Farquharson; A. Dean Sherry. "Synchrotron Radiation X-ray Fluorescence Elemental Mapping in Healthy versus Malignant Prostate Tissues Provides New Insights into the Glucose-Stimulated Zinc Trafficking in the Prostate As Discovered by MRI". Inorganic Chemistry (2019): https://doi.org/10.1021/acs.inorgchem.9b01132.
    10.1021/acs.inorgchem.9b01132
  2. Namini N. Paranawithana; Andre F. Martins; Veronica Clavijo Jordan; Piyu Zhao; Sara Chirayil; Gabriele Meloni; A. Dean Sherry. "A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo". Journal of the American Chemical Society (2019): https://doi.org/10.1021/jacs.8b13493.
    10.1021/jacs.8b13493
  3. Daniel Parrott; W. Shirangi Fernando; Andre Martins. "Smart MRI Agents for Detecting Extracellular Events In Vivo: Progress and Challenges". Inorganics (2019): http://www.mdpi.com/2304-6740/7/2/18.
    10.3390/inorganics7020018
  4. André F. Martins; Veronica Clavijo Jordan; Filip Bochner; Sara Chirayil; Namini Paranawithana; Shanrong Zhang; Su-Tang Lo; et al. "Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions". Journal of the American Chemical Society (2018): https://doi.org/10.1021/jacs.8b07607.
    10.1021/jacs.8b07607
  5. Martins, Andre. "Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor". Molecular Pharmaceutics (2018): http://dx.doi.org/10.1021/acs.molpharmaceut.8b00262.
    10.1021/acs.molpharmaceut.8b00262
  6. Lei Zhang; André F. Martins; Piyu Zhao; Yunkou Wu; Gyula Tircsó; A. Dean Sherry; Martins, Andre. "Lanthanide-Based T2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents". Angewandte Chemie 129 52 (2017): 16853-16857. https://doi.org/10.1002/ange.201707959.
    10.1002/ange.201707959
  7. Lei Zhang; Osasere M. Evbuomwan; Michael Tieu; Piyu Zhao; Andre F. Martins; A. Dean Sherry. "Protonation of carboxyl groups in EuDOTA-tetraamide complexes results in catalytic prototropic exchange and quenching of the CEST signal". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 375 2107 (2017): 20170113-20170113. https://doi.org/10.1098/rsta.2017.0113.
    10.1098/rsta.2017.0113
  8. Martins, Andre. "Transition Metal Doping Reveals Link Between Electron T1 Reduction and 13C Dynamic Nuclear Polarization Efficiency.". The journal of physical chemistry. A (2017): http://europepmc.org/abstract/med/29125294.
    10.1021/acs.jpca.7b09448
  9. Martins, Andre. "Enantiomeric recognition of D- and L-lactate by CEST with the aid of a paramagnetic shift reagent.". Journal of the American Chemical Society (2017): http://europepmc.org/abstract/med/29083166.
    10.1021/jacs.7b08292
  10. Martins, Andre. "Zinc as an Imaging Biomarker of Prostate Cancer". Israel Journal of Chemistry (2017): http://dx.doi.org/10.1002/ijch.201700043.
    10.1002/ijch.201700043
  11. Zohreh Hashami; Andre F. Martins; Alexander M. Funk; Veronica Clavijo Jordan; Stéphane Petoud; Svetlana V. Eliseeva; Zoltan Kovacs; Martins, Andre. "Lanthanide DO3A-Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium". European Journal of Inorganic Chemistry 2017 43 (2017): 4965-4968. https://doi.org/10.1002%2Fejic.201701003.
    10.1002/ejic.201701003
  12. Lei Zhang; André F. Martins; Yuyan Mai; Piyu Zhao; Alexander M. Funk; M. Veronica Clavijo Jordan; Shanrong Zhang; et al. "Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent". Chemistry - A European Journal (2017): https://doi.org/10.1002%2Fchem.201604558.
    10.1002/chem.201604558
  13. Cemile Kumas; W. Shirangi Fernando; Piyu Zhao; Martín Regueiro-Figueroa; Garry E. Kiefer; André F. Martins; Carlos Platas-Iglesias; A. Dean Sherry. "Unexpected Changes in the Population of Coordination Isomers for the Lanthanide Ion Complexes of DOTMA–Tetraglycinate". Inorg. Chem. (2016): http://dx.doi.org/10.1021/acs.inorgchem.6b01390.
    10.1021/acs.inorgchem.6b01390
  14. W. Shirangi Fernando; André F. Martins; Piyu Zhao; Yunkou Wu; Garry E. Kiefer; Carlos Platas-Iglesias; A. Dean Sherry. "Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents". Inorg. Chem. (2016): http://dx.doi.org/10.1021/acs.inorgchem.5b02850.
    10.1021/acs.inorgchem.5b02850
  15. Andhika Kiswandhi; Peter Niedbalski; Christopher Parish; Pavanjeet Kaur; André Martins; Leila Fidelino; Chalermchai Khemtong; et al. "Impact of Ho3+-doping on13C dynamic nuclear polarization using trityl OX063 free radical". Phys. Chem. Chem. Phys. 18 31 (2016): 21351-21359. http://dx.doi.org/10.1039/c6cp03954e.
    10.1039/c6cp03954e
  16. Damien Cressier; Martine Dhilly; Thang T. Cao Pham; Fabien Fillesoye; Fabienne Gourand; Auriane Maïza; André F. Martins; et al. "Gallium-68 Complexes Conjugated to Pittsburgh Compound B: Radiolabeling and Biological Evaluation". Mol Imaging Biol (2015): http://dx.doi.org/10.1007/s11307-015-0906-9.
    10.1007/s11307-015-0906-9
  17. André F. Martins; Alexandre C. Oliveira; Jean-François Morfin; Douglas V. Laurents; Éva Tóth; Carlos F. G. C. Geraldes. "Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aß amyloid aggregates". J Biol Inorg Chem (2015): http://dx.doi.org/10.1007/s00775-015-1316-9.
    10.1007/s00775-015-1316-9
  18. Yu J; Martins AF; Preihs C; Clavijo Jordan V; Chirayil S; Zhao P; Wu Y; et al. "Amplifying the Sensitivity of Zinc(II) Responsive MRI Contrast Agents by Altering Water Exchange Rates.". (2015): http://europepmc.org/abstract/med/26462412.
  19. Luis M. De León-Rodríguez; André F. Martins; Marco C. Pinho; Neil M. Rofsky; A. Dean Sherry. "Basic MR relaxation mechanisms and contrast agent design". J. Magn. Reson. Imaging 42 3 (2015): 545-565. http://dx.doi.org/10.1002/jmri.24787.
    10.1002/jmri.24787
  20. André F. Martins; David M. Dias; Jean-François Morfin; Sara Lacerda; Douglas V. Laurents; Éva Tóth; Carlos F. G. C. Geraldes. "Interaction of PiB-Derivative Metal Complexes with Beta-Amyloid Peptides: Selective Recognition of the Aggregated Forms". Chem. Eur. J. 21 14 (2015): 5413-5422. http://dx.doi.org/10.1002/chem.201406152.
    10.1002/chem.201406152
  21. Martins, André F.; Eliseeva, Svetlana V.; Carvalho, Henrique F.; Teixeira, João M. C.; Paula, Carlos T. B.; Hermann, Petr; Platas-Iglesias, Carlos; et al. "A Bis(pyridine N-oxide) Analogue of DOTA: Relaxometric Properties of the GdIII Complex and Efficient Sensitization of Visible and NIR-Emitting Lanthanide(III) Cations Including PrIII and HoIII". Chemistry – A European Journal (2014): n/a-n/a.
    10.1002/chem.201403856
  22. Monteiro, João P.; Martins, André F.; Nunes, Cláudia; Morais, Catarina M.; Lúcio, Marlene; Reis, Salette; Pinheiro, Teresa J.T.; et al. "A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 8 (2013): 1899-1908.
    Publicado • 10.1016/j.bbamem.2013.04.006
  23. Martins, André F.; Prata, M. I. M.; Rodrigues, S. P. J.; Geraldes, Carlos F. G. C.; Riss, P. J.; Amor-Coarasa, A.; Burchardt, C.; Kroll, C.; Roesch, F.. "Spectroscopic, radiochemical, and theoretical studies of the Ga 3+ - N -2-hydroxyethyl piperazine- N '-2-ethanesulfonic acid (HEPES buffer) system: evidence for the formation of Ga 3+ - HEPES complexes in 68 ¿Ga labeling reactions". Contrast Media & Molecular Imaging 8 3 (2013): 265-273.
    Publicado • 10.1002/cmmi.1517
  24. Martins, André F.; Morfin, Jean-François; Kubicekova, Anna; kubicek; Buron, Frédéric; Suzenet, Franck; Salerno, Milena; et al. "PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of ß-Amyloid Plaques". ACS Medicinal Chemistry Letters 4 5 (2013): 436-440.
    Publicado • 10.1021/ml400042w
  25. Mendonça, Ana C.; Martins, André F.; Melchior, Andrea; Marques, Sérgio M.; Chaves, Sílvia; Villette, Sandrine; Petoud, Stéphane; et al. "New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties". Dalton Transactions 42 17 (2013): 6046-6046.
    Publicado • 10.1039/C2DT32237D
  26. Martins, Andre Ferreira; Ferreira, Miguel F.; Martins, Catarina; Martins, José A.; Tóth, Éva; Rodrigues, Tiago; Geraldes, Carlos F.G.C.; Cerdan, Sebastian; Lopez-Larrubia, Pilar. "Amide conjugates of the DO3A-N-(a-amino)propionate ligand: leads for stable, high relaxivity contrast agents for MRI?". Contrast Media & Molecular Imaging 8 1 (2013): 40-49.
    Publicado
  27. Martins, André F.; Morfin, Jean-François; Geraldes, Carlos F. G. C.; Tóth, Éva. "Gd3+ complexes conjugated to Pittsburgh compound B: potential MRI markers of ß-amyloid plaques". JBIC Journal of Biological Inorganic Chemistry (2013):
    10.1007/s00775-013-1055-8
  28. Ferreira, M. F.; Pereira, G.; Martins, A. F.; Martins, C. I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; et al. "Ln[DO3A-N-a-(pyrenebutanamido)propionate] complexes: optimized relaxivity and NIR optical properties". Dalton Transactions (2013):
    10.1039/c3dt52958d
  29. Lima, Luís M. P.; Delgado, Rita; Hermann, Petr; Šev¿?ík, Radek; Lubal, Premysl; Carvalho, Henrique F.; Martins, André F.; Tóth, Éva; Geraldes, Carlos F. G. C.. "Tris(phosphonomethyl)cyclen Derivatives: Thermodynamic Stability, Kinetics, Solution Structure, and Relaxivity of Ln3+ Complexes". European Journal of Inorganic Chemistry 2012 15 (2012): 2548-2559.
    Publicado • 10.1002/ejic.201101335
  30. Monteiro, João P.; Martins, André F.; Lúcio, Marlene; Reis, Salette; Geraldes, Carlos F. G. C.; Oliveira, Paulo J.; Jurado, Amália S.. "Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling". Journal of Bioenergetics and Biomembranes 43 3 (2011): 287-298.
    Publicado • 10.1007/s10863-011-9359-2
  31. Monteiro, João P.; Martins, André F.; Lúcio, Marlene; Reis, Salette; Pinheiro, Teresa J.T.; Geraldes, Carlos F.G.C.; Oliveira, Paulo J.; Jurado, Amália S.. "Nimesulide interaction with membrane model systems: Are membrane physical effects involved in nimesulide mitochondrial toxicity?". Toxicology in Vitro 25 6 (2011): 1215-1223.
    Publicado • 10.1016/j.tiv.2011.05.014
  32. Chaves, Sílvia; Mendonça, Ana C.; Marques, Sérgio M.; Prata, M. Isabel; Santos, Ana C.; Martins, André F.; Geraldes, Carlos F.G.C.; Santos, M. Amélia. "A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging: solution and in vivo studies of 67Ga-labeled species". Journal of Inorganic Biochemistry 105 1 (2011): 31-38.
    Publicado • 10.1016/j.jinorgbio.2010.09.012
  33. Silvério, Sara; Torres, Susana; Martins, André F.; Martins, José A.; André, João P.; Helm, Lothar; Prata, M. Isabel M.; Santos, Ana C.; Geraldes, Carlos F. G. C.. "Lanthanide chelates of (bis)-hydroxymethyl-substituted DTTA with potential application as contrast agents in magnetic resonance imaging". Dalton Transactions 24 (2009): 4656-4656.
    Publicado • 10.1039/b823402g
  34. Ferreira, Miguel F.; Martins, André F.; Martins, José A.; Ferreira, Paula M.; Tóth, Éva; Geraldes, Carlos F.G.C.. "Gd(DO3A-N-a-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents". Chemical Communications 42 (2009): 6475-6475.
    Publicado • 10.1039/b912201j
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2008 Ln(III) chelates of (bis)-hydroxymethyl substituted N’-benzyl-DTTA: NMR and relaxometric characterization of the Gd(III) complex and in vivo study of the 153Sm(III) labeled compound 3º Encontro Nacional de Estudantes de Bioquímica 2008 (ENEBIOQ)
ENEBIOQ (Coimbra, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2007 - 2007 Vitor Madeira Conference
Conferência (Outra)
 NEBIOQ-AAC, Portugal
2007 - 2007 Nanotechnology
Simpósio (Outra)
 NEBIOQ, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019 - Atual European Molecular Imaging Meeting

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - Atual Pharmaceuticals (1424-8247) MDPI AG
2019 - Atual Metabolites (2218-1989) MDPI AG
2013/07/20 - 2013/08/20 mRNA

Membro de associação

Nome da associação Tipo de participação
2004 - 2013 mRNA (NEBIOQ)
2010 - 2012 ANBIOQ
2008 - 2010 ANBIOQ
2007 - 2008 Academic Student Assotiation (AAC)
2006 - 2007 NEBIOQ
2006 - 2007 University Senate

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020 - Atual Tubingen-Nothingahm Alliance
Membro
 Eberhard Karls Universität Tübingen, Alemanha

University of Nottingham, Reino Unido
Distinções

Prémio

2018 Best Presentation Award
International Society for Magnetic Resonance in Medicine, Estados Unidos
2017 Travel award, World Molecular Imaging Society
World Molecular Imaging Society, Estados Unidos

Título

2019 Junior Academy Member of the Faculty of Medicine, University of Tuebingen
Eberhard Karls Universität Tübingen, Alemanha
2017 Chair at the Annual ACS Meeting San Francisco
American Chemical Society, Estados Unidos

Outra distinção

2017 Qualification Maitre de Conférences Section 64
Gouvernement francais Ministere de l'education nationale, França
2012 Biotechnocentre Best Poster Presentation Award (France)
Region Centre, Portugal
2011 ESMI Poster Award within the category “Probe Design” in the field of Molecular Imaging (The Netherlands)
ESMI, Portugal
1996 National Vice Champion in Canoeing K1 Cadet
FPC, Portugal