???global.info.a_carregar???
Identificação

Identificação pessoal

Nome completo
Jaclyn Winter

Nomes de citação

  • Winter, Jaclyn

Identificadores de autor

Ciência ID
9414-DBB5-70F2
ORCID iD
0000-0001-6273-5377
Formação
Grau Classificação
2010/03/23
Concluído
 Marine Natural Product Biosynthesis (Doctor of Philosophy)
University of California San Diego Scripps Institution of Oceanography, Estados Unidos
2004/05/30
Concluído
 Chemistry and Molecular Genetics (Bachelor)
State University of New York College at Fredonia, Estados Unidos
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/02 - Atual Investigador principal (carreira) (Investigação) The University of Utah, Estados Unidos
2011 - 2015/01/01 Pós-doutorado (Investigação) University of California Los Angeles, Estados Unidos
University of California Los Angeles Department of Chemical and Biomolecular Engineering, Estados Unidos
2010/04/01 - 2011/03/31 Pós-doutorado (Investigação) Hans Knoll Institute, Alemanha
Projetos

Bolsa

Designação Financiadores
2017/07/24 - Atual America's Dead Sea: A Resource for Novel Anti-Cancer Drugs
54503681
Investigador responsável
Concluído
2018/11/15 - 2021/11/14 Decoding Microorganism Communication
7621
Investigador responsável
2020/01/01 - 2020/12/31 Natural Consumption and Evolution of the New Zealand Psychedelic False Truffle Psilocybe weraroa
NGS-62142R-19
Investigador responsável
2017/10/01 - 2018/09/30 Elucidating gene regulation in filamentous fungi for antibiotic discovery
50503252
Investigador responsável
2016/03/15 - 2018/03/14 Novel Systemically-Active Galanin Analogs for the Treatment of Pain
W81XWH-15-1-0380
Outra
Concluído
Produções

Publicações

Artigo em revista
  1. Jaclyn Winter. "Expressing genes in Saccharomyces cerevisiae". protocols.io (2019): https://www.protocols.io/view/expressing-genes-in-saccharomyces-cerevisiae-8gchtsw.
    dx.doi.org/10.17504/protocols.io.8gchtsw
  2. Jaclyn Winter. "Protein expression in yeast". protocols.io (2019): https://www.protocols.io/view/protein-expression-in-yeast-8gahtse.
    dx.doi.org/10.17504/protocols.io.8gahtse
  3. Jaclyn Winter. "Advanced Marfey's". protocols.io (2019): https://www.protocols.io/view/advanced-marfey-x27-s-8f6htre.
    dx.doi.org/10.17504/protocols.io.8f6htre
  4. Jaclyn Winter. "Single nick pCrispomyces 2". protocols.io (2019): https://www.protocols.io/view/single-nick-pcrispomyces-2-8f5htq6.
    dx.doi.org/10.17504/protocols.io.8f5htq6
  5. Jaclyn Winter. "cpf1 cloning". protocols.io (2019): https://www.protocols.io/view/cpf1-cloning-8f4htqw.
    dx.doi.org/10.17504/protocols.io.8f4htqw
  6. Shang, Z.; Winter, J.M.; Kauffman, C.A.; Yang, I.; Fenical, W.. "Salinipeptins: Integrated Genomic and Chemical Approaches Reveal Unusual d -Amino Acid-Containing Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) from a Great Salt Lake Streptomyces sp.". ACS Chemical Biology 14 3 (2019): 415-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062542894&partnerID=MN8TOARS.
    10.1021/acschembio.8b01058
  7. Winter, Jaclyn. "Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp.". Marine Drugs (2017): http://www.mdpi.com/1660-3397/15/7/195.
    10.3390/md15070195
  8. Sato, M.; Dander, J.E.; Sato, C.; Hung, Y.-S.; Gao, S.-S.; Tang, M.-C.; Hang, L.; et al. "Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases". Journal of the American Chemical Society 139 15 (2017): 5317-5320. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018504230&partnerID=MN8TOARS.
    10.1021/jacs.7b02432
  9. Agarwal, V.; Miles, Z.D.; Winter, J.M.; Eustáquio, A.S.; El Gamal, A.A.; Moore, B.S.. "Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse". Chemical Reviews 117 8 (2017): 5619-5674. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018814792&partnerID=MN8TOARS.
    10.1021/acs.chemrev.6b00571
  10. Sato, M.; Winter, J.M.; Kishimoto, S.; Noguchi, H.; Tang, Y.; Watanabe, K.. "Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis". Organic Letters 18 6 (2016): 1446-1449. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961777950&partnerID=MN8TOARS.
    10.1021/acs.orglett.6b00380
  11. Cochrane, R.V.K.; Gao, Z.; Lambkin, G.R.; Xu, W.; Winter, J.M.; Marcus, S.L.; Tang, Y.; Vederas, J.C.. "Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs". ChemBioChem 16 17 (2015): 2479-2483. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955194832&partnerID=MN8TOARS.
    10.1002/cbic.201500428
  12. Winter, J.M.; Cascio, D.; Dietrich, D.; Sato, M.; Watanabe, K.; Sawaya, M.R.; Vederas, J.C.; Tang, Y.. "Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis". Journal of the American Chemical Society 137 31 (2015): 9885-9893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938931415&partnerID=MN8TOARS.
    10.1021/jacs.5b04520
  13. Winter, J.M.; Tang, Y.. "Natural products: Getting a handle on peptides". Nature Chemistry 6 12 (2014): 1037-1038. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911498604&partnerID=MN8TOARS.
    10.1038/nchem.2117
  14. Winter, J.M.; Chiou, G.; Bothwell, I.R.; Xu, W.; Garg, N.K.; Luo, M.; Tang, Y.. "Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain". Organic Letters 15 14 (2013): 3774-3777. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880521217&partnerID=MN8TOARS.
    10.1021/ol401723h
  15. Winter, J.M.; Tang, Y.. "Synthetic biological approaches to natural product biosynthesis". Current Opinion in Biotechnology 23 5 (2012): 736-743. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865515585&partnerID=MN8TOARS.
    10.1016/j.copbio.2011.12.016
  16. Winter, J.M.; Sato, M.; Sugimoto, S.; Chiou, G.; Garg, N.K.; Tang, Y.; Watanabe, K.. "Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase". Journal of the American Chemical Society 134 43 (2012): 17900-17903. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868110726&partnerID=MN8TOARS.
    10.1021/ja3090498
  17. Bernhardt, P.; Okino, T.; Winter, J.M.; Miyanaga, A.; Moore, B.S.. "A stereoselective vanadium-dependent chloroperoxidase in bacterial antibiotic biosynthesis". Journal of the American Chemical Society 133 12 (2011): 4268-4270. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953057976&partnerID=MN8TOARS.
    10.1021/ja201088k
  18. Udwary, D.W.; Gontang, E.A.; Jones, A.C.; Jones, C.S.; Schultz, A.W.; Winter, J.M.; Yang, J.Y.; et al. "Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses". Applied and Environmental Microbiology 77 11 (2011): 3617-3625. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958290073&partnerID=MN8TOARS.
    10.1128/AEM.00038-11
  19. Winter, J.M.; Behnken, S.; Hertweck, C.. "Genomics-inspired discovery of natural products". Current Opinion in Chemical Biology 15 1 (2011): 22-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-79851507787&partnerID=MN8TOARS.
    10.1016/j.cbpa.2010.10.020
  20. Winter, J.M.; Moore, B.S.. "Exploring the chemistry and biology of vanadium-dependent haloperoxidases". Journal of Biological Chemistry 284 28 (2009): 18577-18581. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650539068&partnerID=MN8TOARS.
    10.1074/jbc.R109.001602
  21. Winter, J.M.; Jansma, A.L.; Handel, T.M.; Moore, B.S.. "Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone". Angewandte Chemie - International Edition 48 4 (2009): 767-770. http://www.scopus.com/inward/record.url?eid=2-s2.0-58249098607&partnerID=MN8TOARS.
    10.1002/anie.200805140
  22. Winter, J.M.; Moffitt, M.C.; Zazopoulos, E.; McAlpine, J.B.; Dorrestein, P.C.; Moore, B.S.. "Molecular basis for chloronium-mediated meroterpene cyclization: Cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster". Journal of Biological Chemistry 282 22 (2007): 16362-16368. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447558011&partnerID=MN8TOARS.
    10.1074/jbc.M611046200
  23. Cifuentes, M.; Schilling, B.; Ravindra, R.; Winter, J.; Janik, M.E.. "Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs". Bioorganic and Medicinal Chemistry Letters 16 10 (2006): 2761-2764. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645848477&partnerID=MN8TOARS.
    10.1016/j.bmcl.2006.02.010

Outros

Outra produção
  1. Animal biosynthesis of complex polyketides in a photosynthetic partnership. 2019. Joshua P. Torres; Zhenjian Lin; Jaclyn M. Winter; Patrick J. Krug; Eric W. Schmidt. https://doi.org/10.1101/764225.
    10.1101/764225
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020 Title TBD 3rd International Conference of the Marine Fungal Natural Products
(Nice, França)
2020 Exploring the Chemical Potential of Great Salt Lake Microorganisms Pacifichem
(Honolulu, Estados Unidos)
2020 Unlocking the Chemical Potential of the Fungal Terpenome Marine Natural Products Gordon Research Conference
(Ventura, Estados Unidos)
2020 Developing Microorganisms for Drug Discovery National Cancer Institute
(Frederick, Estados Unidos)
2020 Genomics-Assisted Antibiotic Discovery from Unprecedented Microbes of the Great Salt Lake Perlman Symposium
University of Wisconsin (Madison, Estados Unidos)
2020 Developing Microorganisms for Drug Discovery Department of Chemistry and Chemical Biology
University of New Mexico (Albuquerque, Estados Unidos)
2019 Chemical Potential of Great Salt Lake Microorganisms XVI International Symposium on Marine Natural Products
(Peniche, Portugal)
2019 Engineering a Heterologous Expression Platform for Fungal Terpene Biosynthesis 2nd Synthetic Biology for Natural Products Conference
(Puerto Vallarta, México)
2019 Exploring the Chemical Potential of Great Salt Lake Microorganisms American Society of Pharmacognosy
(Madison, Estados Unidos)
2019 Developing Microorganisms for Drug Discovery Department of Chemistry Seminar Program
Oregon State (Corvallis, Estados Unidos)
2019 Developing Microorganism Communication for Antibiotic Discovery Vitae
University of Utah Health (Salt Lake City, Estados Unidos)
2019 Developing Microorganisms for Drug Discovery Immunology, Inflammation and Infectious Disease Annual Symposium
University of Utah (Salt Lake City, Estados Unidos)
2018 Exploring the Chemical Potential of Great Salt Lake Microorganisms American Society of Pharmacognosy
(Lexington, Estados Unidos)
2018 Developing Heterologous Expression Platforms for Fungal Terpenes Industrial Synthetic Biology Congress
(Munich, Alemanha)
2018 Engineering Heterologous Expression Platforms for Elucidating Fungal Terpene Biosynthesis Canadian Chemistry Conference
(Alberta, Canadá)
2018 Engineering a Heterologous Expression Platform for Fungal Terpene Biosynthesis Poulter Endowed Lectureships
Department of Chemistry at the University of Utah (Salt Lake City, Estados Unidos)
2018 Developing Microorganisms for Drug Discovery American Association of Pharmaceutical Scientists
Rocky Mountain Discussion Group, University of Washington (Seattle, Estados Unidos)
2017 Identification of the Mangicol Biosynthetic Gene Cluster in Fusarium equiseti CNC-477 and Characterization of its Sesterterpene Synthase American Society of Pharmacognosy
(Portland, Estados Unidos)
2017 Developing Heterologous Expression Platforms for Elucidating Fungal Natural Product Biosynthesis Keystone Symposia on Natural Products and Synthetic Biology: Parts and Pathways
(Olympic Valley, Estados Unidos)
2017 Exploiting Microorganisms for Drug Discovery Microbial Pathogenesis Seminar Series
University of Utah (Salt Lake City, Estados Unidos)
2016 Fungal Natural Products: Elucidating the Biosynthesis of the Good, the Bad and the Unknown LS Skaggs Biomedical Research Symposium
(Pocatello, Estados Unidos)
2015 Elucidating the Biosynthesis of Fungal Azaphilone Natural Products from Chaetomium globosum Bioscience Symposium
University of Utah (Salt Lake City, Estados Unidos)
2013 Identifying and Characterizing Fungal Polyketide Synthases Involved in the Biosynthesis of the Chaetoviridin and Chaetomugilin Azaphilones Society of Industrial Microbiology and Biotechnology
(San Diego, Estados Unidos)
2010 Investigation the Biosynthesis of Halogenated Meroterpenoid Natural Products from Marine Actinomycetes Society for General Microbiology
(Dublin, Irlanda)
2008 The Napyradiomycin Biosynthetic Cluster Provides a Powerful Toolbox to Study Unique Halogenating Enzymes Society of Industrial Microbiology and Biotechnology
(San Diego, Estados Unidos)
2008 Aspects in Azamerone Biosynthesis, Formation of the Unprecedented Phthalazinone Core American Chemical Society Western Regional Meeting
(Las Vegas, Estados Unidos)

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019 - Atual 2020 International Congress on Natural Products Research

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2019 - Atual First Round Grant Reviewer
Avaliador
 Gordon and Betty Moore Foundation, Estados Unidos
2018 - Atual First Round Grant Reviewer
Avaliador
 Fondation L'Oréal, França

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2015 - Atual Scientific Reviewer Génome Québec, Canadá

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018 - Atual Bioscience Capstone Examiner (Doctor of Philosophy) The University of Utah, Estados Unidos
2017 - Atual Integrated Pharmacotherapeutics II (Doctor of Philosophy) The University of Utah College of Pharmacy, Estados Unidos
2016 - Atual Foundations in Biochemistry (Doctor of Philosophy) The University of Utah College of Pharmacy, Estados Unidos
2017 - 2017 Integrated Pharmacotherapeutics III The University of Utah College of Pharmacy, Estados Unidos
2017 - 2017 Mycology (Bachelor) The University of Utah, Estados Unidos
2015 - 2017 Research Seminar (Doctor of Philosophy) The University of Utah College of Pharmacy, Estados Unidos
2015 - 2016 Organic Medicinal Chemistry II (Doctor of Philosophy) The University of Utah College of Pharmacy, Estados Unidos

Membro de associação

Nome da associação Tipo de participação
2016 - Atual American Society of Pharmacognosy Younger Members Committee Chair
2015/06/01 - Atual American Society of Pharmacognosy Member
2013 - Atual American Chemical Society
2013 - Atual American Association for the Advancement of Science Member
2015 - 2019 American Association of Colleges of Pharmacy Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019 - Atual Steering Committee Member for the Biological Chemistry Graduate Program The University of Utah, Estados Unidos
2018 - Atual Scientific Advisory Board for the Immunology, Inflammation and Infectious Diseases Initiative The University of Utah, Estados Unidos
2017 - Atual Steering Committee Member for the Presidential Commission on the Status of Women The University of Utah, Estados Unidos
2016 - Atual T32 Steering Committee Member for the Biological Chemistry Graduate Program's Interdisciplinary Training Program in Chemical Biology The University of Utah, Estados Unidos
2015 - Atual Faculty Sponsor and Student Mentor for the College of Pharmacy The University of Utah College of Pharmacy, Estados Unidos
2015 - Atual Member of the Biological Chemistry Graduate Program The University of Utah, Estados Unidos
2019 - 2020 Faculty Search Committee for the Department of Medicinal Chemistry The University of Utah, Estados Unidos
2018 - 2019 Admission Chair for the Biological Chemistry Graduate Program The University of Utah, Estados Unidos
2016 - 2019 Steering Committee Member for Women in Health, Medicine and Science University of Utah Health, Estados Unidos
2015 - 2019 Admission Committee Member for the Biological Chemistry Graduate Program The University of Utah, Estados Unidos
2017 - 2018 Curriculum Chair for the Biological Chemistry Graduate Program The University of Utah, Estados Unidos
2016 - 2018 Faculty Search Committee Member for the Department of Biochemistry The University of Utah, Estados Unidos
2016 - 2017 Faculty Search Committee for the Department of Pharmacology and Toxicology, USTAR Position in Cancer Therapeutics The University of Utah, Estados Unidos
2016 - 2017 Co-Curriculum Chair for the Biological Chemistry Graduate Program The University of Utah, Estados Unidos

Tutoria

Tópico Nome do aluno
2019 - Atual Dr. Peng Zhang
2019 - Atual Dr. David Gallegos
2019 - Atual Uonita Khachoomian
2018 - Atual Jeannette Dimpel
2017 - Atual Stephanie Heard
2016 - Atual Randy Chou
2019 - 2019 Matthew Savas
2019 - 2019 Abbey Smith
2017 - 2018 Chris Fullmer
2016 - 2018 Dr. Emilio Cortez
2015 - 2018 Heilly Galvez
2017 - 2017 Cy Perkins
2015 - 2017 Dr. Stephen Bell
2007 - 2010 Michelle Hook
Distinções

Prémio

2018 2017-2018 College of Pharmacy Teacher of the Year
The University of Utah College of Pharmacy, Estados Unidos
2018 Third Profession Year Teacher of the Year
The University of Utah College of Pharmacy, Estados Unidos
2012 L'Oreal/AAAS USA Postdoctoral Fellowship for Women in Science
L'Oreal USA, Estados Unidos

American Association for the Advancement of Science, Estados Unidos
2008 Outstanding Student Oral Presenter at the Society of Industrial Microbiology Meeting
2007 Claude ZoBell Fellowship for Microbiologist of the Year
University of California San Diego Scripps Institution of Oceanography, Estados Unidos
2006 NIH Marine Biotechnology Predoctoral Ruth L. Kirschstein National Research Service Award
University of California San Diego Scripps Institution of Oceanography, Estados Unidos
2004 Roy Keller Award for Undergraduate Researcher of the Year
State University of New York College at Fredonia, Estados Unidos
2002 Merck/AAAS Undergraduate Research Fellowship
State University of New York College at Fredonia, Estados Unidos

Outra distinção

2019 Selected as a presenter for the Senior Vice President of Health Science's Vitae event
The University of Utah, Estados Unidos
2018 Scialog Fellow for Chemical Machinery of the Cell
Research Corporation for Science Advancement, Estados Unidos

Gordon and Betty Moore Foundation, Estados Unidos
2016 Vice President's Clinical and Translational Scholars Program
University of Utah Health, Estados Unidos