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Dr Eduardo Sousa earned his PhD in Chemistry (Bioinorganic chemistry, 2003) in the Graduate Program of Chemistry of the Federal University of Ceará (Brazil), while spent time also investigating recombinant metalloproteins at the San Francisco State University (USA). From 2004 to 2009, he worked with Dr Marie-Alda Gilles-Gonzalez as a pos-doctor and later research scientist at the University of Texas Southwestern Medical Center (USA), investigating heme-based sensor proteins. In 2009, he was recruited by the Department of Organic and Inorganic Chemistry at the Federal University of Ceará (Brazil), when he joined the Bioinorganic chemistry group, and, in 2017, was promoted to associate professor. He also spent times as a visiting researcher at the University of Warwick (2013-2014, prof Peter Sadler’s lab) and Universidade Nova de Lisboa (2019-2020, prof José Moura’s lab), while worked as ad hoc consulting to Brazilian (CNPq) and foreign scientific agencies (British Society for Antimicrobial Chemotherapy and Czech Science Foundation). Currently, he is member of the National Institute of Science and Technology themed Tuberculosis, and has published 65 peer-reviewed papers. Additionally, he wrote 7 book chapters and filed 3 patents, besides production of one educational software. He was advisor and co-advisor of 17 Master students and 7 PhD students, along with supervision of 2 pos-doctors. His current interests are on the role of metals in biology, particularly focused on the development of metallodrugs and heme-based sensors with interest in Mycobacterium tuberculosis.
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Identificação

Identificação pessoal

Nome completo
Eduardo Henrique Silva de Sousa

Nomes de citação

  • Sousa, Eduardo
  • Sousa, E. H. S.
  • de Sousa, E. H. S.
  • Sousa, E. H.

Identificadores de autor

Ciência ID
9817-BDD0-0734
ORCID iD
0000-0002-0007-8452

Domínios de atuação

  • Ciências Exatas - Química - Química Inorgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2003
Concluído
 Programa de Pós-Graduação em Química (Doutoramento)
Universidade Federal do Ceará, Brasil
"REATIVIDADE DE COMPOSTOS INORGANICOS QUE INIBEM A 2-TRANS-ENOIL-ACP(CoA) REDUTASE, UM ALVO ANTI-TUBERCULOSE" (TESE/DISSERTAÇÃO)
 n/a
2000
Concluído
 Programa de Pós-GRaduação em Química (Mestrado)
Universidade Federal do Ceará, Brasil
"Estudo da reatividade dos ligantes tionicotinamida e isoniazida" (TESE/DISSERTAÇÃO)
 n/d
1998
Concluído
 Bacharelado em Química (Bacharelato)
Universidade Federal do Ceará, Brasil
"n/d" (TESE/DISSERTAÇÃO)
 n/d
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/05 - 2020/01/30 Investigador visitante (Investigação) Universidade Federal do Ceará, Brasil
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008/05/01 - 2009/01/20 Investigador (Investigação) The University of Texas Southwestern Medical Center, Estados Unidos

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2009/01/26 - 2017/04/18 Professor associado do Departamento de Química Orgânica e Inorgânica (situação atual) Universidade Federal do Ceará, Brasil
2013/01/31 - 2014/02/01 Pesquisador (liberado tipo sabático), Department of Chemistry University of Warwick, Reino Unido
2004/06/24 - 2008/04/30 Post-doctoral researcher The University of Texas Southwestern Medical Center, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2016/01 - 2018/01 Investigação de Hemeproteínas Sensoras: mecanismos e reguladores
88881.068193/2014-01
 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Projeto

Designação Financiadores
2016/01/02 - 2020/12/31 Potenciais Fármacos Anti-Tuberculose: Novas Estratégias no Combate à Tuberculose Latente e a Resistência Múltipla às Droga
88887.130198/2017-01
Investigador
Universidade Federal do Ceará, Brasil
Em curso
2017/06/01 - 2020/05/28 Metaloproteínas Sensoras: mecanismos moleculares e a identificação de reguladores com potencialidades farmacológicas
403866/2016-2
Investigador responsável
Universidade Federal do Ceará, Brasil
Em curso
2016/07/02 - 2019/07/01 Compostos de Coordenação: Da Modelagem Molecular à Produção de Metalofármacos e Novos Materiais
PR2 0101-00030.01.00/15 SPU Nº: 3265612/2015
Investigador
Universidade Federal do Ceará, Brasil
Concluído
Produções

Publicações

Artigo em conferência
  1. Sabino, L.G.; Guimarães, W.G.; Costa, P.M.; Carepo, M.S.P.; Gondim, A.C.S.; Lopes, L.G.F.; Sousa, E.H.S.. "The application of low angle light scattering to evaluate qualitatively and quantitatively the dynamics of formation of oligomers in heme protein sensors". 2016.
    10.1117/12.2213733
Artigo em revista
  1. Geângela de Fátima Sousa Oliveira; Florencio Sousa Gouveia; Aryane de Azevedo Pinheiro; Luiz Gonzaga do Nascimento Neto; Mayron Alves de Vasconcelos; Edson Holanda Teixeira; Ana Claudia Silva Gondim; et al. "An anthracene-pendant ruthenium(ii) complex conjugated to a biotin anchor, an essential handle for photo-induced anti-cancer activity". New Journal of Chemistry (2020): https://doi.org/10.1039/D0NJ00209G.
    10.1039/D0NJ00209G
  2. Giamwemberg A. Barreto; Marta S. P. Carepo; Ana C. S. Gondim; Wellinson G. Guimarães; Luiz G. F. Lopes; Paul V. Bernhardt; Tércio F. Paulo; Eduardo H. S. Sousa; Izaura C. N. Diógenes. "A spectroelectrochemical investigation of the heme-based sensor DevS from Mycobacterium tuberculosis : a redox versus oxygen sensor". The FEBS Journal (2019): https://doi.org/10.1111/febs.14974.
    10.1111/febs.14974
  3. Pedro M. Silva Filho; Iury A. Paz; Nilberto R. F. Nascimento; Cláudia F. Santos; Valdevane R. Araújo; Camila P. Aquino; T. S. Ribeiro; et al. "Incorporation of Nitroprusside on Silica Nanoparticles—A Strategy for Safer Use of This NO Donor in Therapy". Molecular Pharmaceutics (2019): https://doi.org/10.1021/acs.molpharmaceut.9b00110.
    10.1021/acs.molpharmaceut.9b00110
  4. Nilberto Robson Falcão do Nascimento; Francisco Léo Nascimento de Aguiar; Cláudia Ferreira Santos; Angélica Maria Luna Costa; Daiana de Jesus Hardoim; Kátia da Silva Calabrese; Fernando Almeida-Souza; et al. "In vitro and in vivo leishmanicidal activity of a ruthenium nitrosyl complex against Leishmania (Viannia) braziliensis". Acta Tropica 192 (2019): 61-65. https://doi.org/10.1016/j.actatropica.2019.01.021.
    10.1016/j.actatropica.2019.01.021
  5. Sousa, Eduardo. "Effect of Crotalus basiliscus snake venom on the redox reaction of myoglobin". JBIC Journal of Biological Inorganic Chemistry (2019): http://dx.doi.org/10.1007/s00775-019-01636-7.
    10.1007/s00775-019-01636-7
  6. Josiane Bezerra da Silva Lobão; Ana C. S. Gondim; Wellinson G. Guimarães; Marie-Alda Gilles-Gonzalez; Luiz Gonzaga de França Lopes; Eduardo H. S. Sousa. "Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure". The FEBS Journal 286 3 (2019): 479-494. https://doi.org/10.1111/febs.14734.
    10.1111/febs.14734
  7. Adolfo I. B. Romo; Vitória S. Dibo; Dieric S. Abreu; Marta S. P. Carepo; Andrea C. Neira; Ivan Castillo; Luis Lemus; et al. "Ascorbyl and hydroxyl radical generation mediated by a copper complex adsorbed on gold". Dalton Transactions (2019): https://doi.org/10.1039/C9DT01726G.
    10.1039/C9DT01726G
  8. Falcao Nascimento, Nilberto Robson; Franca Lopes, Luiz Gonzaga; Silva Sousa, Eduardo Henrique; Santos, Claudia Ferreira; Paz, Iury Araujo; Silva Filho, Pedro Martins; Longhinotti, Elisane; Fonteles, Manasses Claudino. "Sodium nitroprusside encapsulated in Silica nanoparticles as a strategy for safer nitric oxide delivery". The FASEB Journal (2019): https://publons.com/publon/30506774/.
  9. Gilles-Gonzalez, Marie-Alda; Sousa, Eduardo H. S.. "Escherichia coli DosC and DosP: a role of c-di-GMP in compartmentalized sensing by degradosomes". Advances in Microbial Physiology (2019): https://publons.com/publon/30565504/.
    10.1016/BS.AMPBS.2019.05.002
  10. Edinaira Nunes; Anne Drumond Villela; Luiz Augusto Basso; Edson Teixeira; Alexandre Andrade; Mayron Vasconcelos; Luiz Nascimento Neto; et al. "Light-induced disruption of an acyl hydrazone link as a novel strategy for drug release and activation: isoniazid as a proof-of-concept case". Inorganic Chemistry Frontiers (2019): https://publons.com/publon/26789726/.
    10.1039/C9QI01172B
  11. de Sousa, Aurideia P.; do Nascimento, Juliana S.; Ayala, Alejandro Pedro; Bezerra, Beatriz Pinheiro; Sousa, Eduardo H. S.; Lopes, Luiz G. F.; Holanda, Alda K. M.. "A new water-soluble ruthenium(II) carbonyl complex: cis-[Ru (bpy)(2)(SO3)(CO)]". Polyhedron (2019): https://publons.com/publon/20911208/.
    10.1016/J.POLY.2019.04.017
  12. Sousa, Eduardo. "Structural aspects and physiological implications of the hemoglobin of green iguana (Iguana iguana)". International Journal of Biological Macromolecules (2018): http://dx.doi.org/10.1016/j.ijbiomac.2018.08.174.
    10.1016/j.ijbiomac.2018.08.174
  13. Sousa, Eduardo. "Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?". Frontiers in Microbiology (2018): http://dx.doi.org/10.3389/fmicb.2018.00880.
    10.3389/fmicb.2018.00880
  14. de Sousa, A. P.; Ellena, J.; Gondim, A. C. S.; Lopes, L. G. F.; Sousa, E. H. S.; de Vasconcelos, M. A.; Teixeira, E. H.; Ford, P. C.; Holanda, A. K. M.. "Antimicrobial activity of cis- Ru(bpy)(2)(L)(L ') (n+) complexes, where L=4-(4-chlorobenzoyl)pyridine or 4-(benzoyl)pyridine and L ' = Cl- or CO". Polyhedron 144 (2018): 88-94. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000428829400012&KeyUID=WOS:000428829400012.
    10.1016/j.poly.2018.01.002
  15. Silva, C. D. S.; Paz, I. A.; Abreu, F. D.; de Sousa, A. P.; Verissimo, C. P.; Nascimento, N. R. F.; Paulo, T. F.; et al. "Thiocarbonyl-bound metallonitrosyl complexes with visible-light induced DNA cleavage and promising vasodilation activity". Journal of Inorganic Biochemistry 182 (2018): 83-91. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000430157000009&KeyUID=WOS:000430157000009.
    10.1016/j.jinorgbio.2018.02.005
  16. Laborde, J.; Deraeve, C.; Vieira, F. G. D.; Soumia-Saquet, A.; Rechignat, L.; Villela, A. D.; Abbadi, B. L.; et al. "Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy". Journal of Inorganic Biochemistry 179 (2018): 71-81. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000423497200008&KeyUID=WOS:000423497200008.
    10.1016/j.jinorgbio.2017.11.013
  17. Wendy M. T. Q. de Medeiros; Mayara J. C. de Medeiros; Edinilton M. Carvalho; Jailma A. de Lima; Verônica da S. Oliveira; Ana C. F. de B. Pontes; Francisco O. N. da Silva; et al. "A vanillin-based copper(ii) metal complex with a DNA-mediated apoptotic activity". RSC Advances (2018): https://doi.org/10.1039/C8RA03626H.
    10.1039/C8RA03626H
  18. Eduardo H. S. Sousa; Gonzalo Gonzalez; Marie-Alda Gilles-Gonzalez. "Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT". The FEBS Journal 284 22 (2017): 3954-3967. https://doi.org/10.1111/febs.14284.
    10.1111/febs.14284
  19. Felipe Diógenes Abreu; Tercio de F. Paulo; Marcelo H. Gehlen; Rômulo A. Ando; Luiz G. F. Lopes; Ana Cláudia S. Gondim; Mayron A. Vasconcelos; et al. "Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding". Inorganic Chemistry 56 15 (2017): 9084-9096. https://doi.org/10.1021/acs.inorgchem.7b01108.
    10.1021/acs.inorgchem.7b01108
  20. Eduardo Henrique Silva Sousa; Luiz Gonzaga de França Lopes; Gonzalo Gonzalez; Marie-Alda Gilles-Gonzalez. "Drug discovery targeting heme-based sensors and their coupled activities". Journal of Inorganic Biochemistry 167 (2017): 12-20. http://dx.doi.org/10.1016/j.jinorgbio.2016.11.022.
    10.1016/j.jinorgbio.2016.11.022
  21. Sousa, E. H. S.; Silva, P. M.; Paz, Y. A.; Nascimento, N. R. F.; Longhinotti, E.. "Nitroprusside Anchored to Silica Nanoparticles - a Promising Future". Journal of Biological Inorganic Chemistry 22 (2017): S110-S110. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419606600079&KeyUID=WOS:000419606600079.
  22. de Sousa, A. P.; Fernandes, A. F.; Paz, I. A.; Nascimento, N. R. F.; Ellena, J.; Sousa, E. H. S.; Lopes, L. G. F.; Holanda, A. K. M.. "A Potential Visible-Light NO Releaser: Synthesis, Reactivity and Vasodilator Properties". Journal of the Brazilian Chemical Society 28 11 (2017): 2117-2129. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000412117900009&KeyUID=WOS:000412117900009.
    10.21577/0103-5053.20170057
  23. Guimarães, W.G.; Gondim, A.C.S.; Costa, P.M.D.S.; Gilles-Gonzalez, M.-A.; Lopes, L.G.F.; Carepo, M.S.P.; Sousa, E.H.S.. "Insights into signal transduction by a hybrid FixL: Denaturation study of on and off states of a multi-domain oxygen sensor". Journal of Inorganic Biochemistry 172 (2017): 129-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018185960&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2017.04.013
  24. Gondim, A. C. S.; Romero-Canelon, I.; Sousa, E. H. S.; Blindauer, C. A.; Butler, J. S.; Romero, M. J.; Sanchez-Cano, C.; et al. "The potent anti-cancer activity of Dioclea lasiocarpa lectin". Journal of Inorganic Biochemistry 175 (2017): 179-189. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000411919000019&KeyUID=WOS:000411919000019.
    10.1016/j.jinorgbio.2017.07.011
  25. Gazzi, T. P.; Rotta, M.; Villela, A. D.; Rodrigues, V.; Martinelli, L. K. B.; Sales, F. A. M.; de Sousa, E. H. S.; et al. "Synthesis, Inhibition of Mycobacterium tuberculosis Enoyl-acyl Carrier Protein Reductase and Antimycobacterial Activity of Novel Pentacyanoferrate(II)-isonicotinoylhydrazones". Journal of the Brazilian Chemical Society 28 10 (2017): 2028-2037. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000411813200024&KeyUID=WOS:000411813200024.
    10.21577/0103-5053.20170033
  26. Nascimento, N. R. F.; Cabral, P. H. B.; Sousa, E. H. S.; Lopes, L. G. F.; Paz, I. A.; Santos, C. F.; Fonteles, M. C.. "Ru(bipyridine)(2)(thiourea)(NO) has Long Lasting Antihypertensive Effects in 2Kidney-1Clip and Dahl-Salt Sensitive Hypertensive Rats". Faseb Journal 31 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000405986501750&KeyUID=WOS:000405986501750.
  27. de Sousa, A. P.; Carvalho, E. M.; Ellena, J.; Sousa, E. H. S.; de Sousaa, J. R.; Lopes, L. G. F.; Ford, P. C.; Holanda, A. K. M.. "Photochemical studies of cis- Ru(bpy)(2)(4-bzpy)(CO) (PF6)(2) and cis- Ru (bpy)(2)(4-bzpy)(Cl) (PF6): Blue light-induced nucleobase binding". Journal of Inorganic Biochemistry 173 (2017): 144-151. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000405159600016&KeyUID=WOS:000405159600016.
    10.1016/j.jinorgbio.2017.05.006
  28. José Marcos da Silveira Carvalho; Andressa Hellen de Morais Batista; Nádia Accioly Pinto Nogueira; Alda Karine Medeiros Holanda; Jackson Rodrigues de Sousa; Dávila Zampieri; Maria Júlia Barbosa Bezerra; et al. "A biphosphinic ruthenium complex with potent anti-bacterial and anti-cancer activity". New J. Chem. 41 21 (2017): 13085-13095. https://doi.org/10.1039/C7NJ02943H.
    10.1039/C7NJ02943H
  29. Adolfo I. B. Romo; Dieric S. Abreu; Tércio de F. Paulo; Marta S. P. Carepo; Eduardo H. S. Sousa; Luis Lemus; Carolina Aliaga; et al. "Hydroxyl Radical Generation and DNA Nuclease Activity: A Mechanistic Study Based on a Surface-Immobilized Copper Thioether Clip-Phen Derivative". Chemistry - A European Journal 22 29 (2016): 10081-10089. https://doi.org/10.1002%2Fchem.201601719.
    10.1002/chem.201601719
  30. Leitao Junior, A. S.; Campos, R. M.; Cerqueira, J. B. G.; Fonteles, M. C.; Santos, C. F.; de Nucci, G.; Sousa, E. H. S.; et al. "Relaxant effect of a metal-based drug in human corpora cavernosa and its mechanism of action". International Journal of Impotence Research 28 1 (2016): 20-24. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000367770700005&KeyUID=WOS:000367770700005.
    10.1038/ijir.2015.27
  31. Silva Sousa, E.H.; Ridnour, L.A.; Gouveia, F.S.; Silva Da Silva, C.D.; Wink, D.A.; De França Lopes, L.G.; Sadler, P.J.. "Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1a Inhibition for Cancer Therapy". ACS Chemical Biology 11 7 (2016): 2057-2065. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978705861&partnerID=MN8TOARS.
    10.1021/acschembio.6b00222
  32. Honorio-Felício, N.; Carepo, M.S.P.; de F. Paulo, T.; de França Lopes, L.G.; Sousa, E.H.S.; Diógenes, I.C.N.; Bernhardt, P.V.. "The Heme-Based Oxygen Sensor Rhizobium etli FixL: Influence of Auxiliary Ligands on Heme Redox Potential and Implications on the Enzyme Activity". Journal of Inorganic Biochemistry 164 (2016): 34-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-84993995835&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2016.08.009
  33. Abreu, F.D.; Diógenes, I.C.N.; Lopes, L.G.D.F.; Sousa, E.H.S.; De Carvalho, I.M.M.. "Ruthenium(II) bipyridine complexes with pendant anthracenyl and naphthyl moieties: A strategy for a ROS generator with DNA binding selectivity". Inorganica Chimica Acta 439 (2016): 92-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945156624&partnerID=MN8TOARS.
    10.1016/j.ica.2015.09.034
  34. Santana, Ana Paula M.; Tavares, Bruno M.; Lucetti, Larisse T.; Gouveia, Florencio S., Jr.; Ribeiro, Ronaldo A.; Soares, Pedro M. G.; Sousa, Eduardo H. S.; et al. "The nitric oxide donor cis- Ru(bpy)(2)(SO3)NO (PF6) increases gastric mucosa protection in mice - Involvement of the soluble guanylate cyclase/K (ATP pathway)". Nitric Oxide-Biology and Chemistry 45 (2015): 35-42. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351479400007&KeyUID=WOS:000351479400007.
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  35. Cândido, M.C.L.; Oliveira, A.M.; Silva, F.O.N.; Holanda, A.K.M.; Pereira, W.G.; Sousa, E.H.S.; Carneiro, Z.A.; Silva, R.S.; Lopes, L.G.F.. "Photochemical and electrochemical study of the release of nitric oxide from [Ru(bpy)<inf>2</inf>L(NO)](PF<inf>6</inf>)<inf>n</inf> complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), toward the development of therapeutic photodynamic agents". Journal of the Brazilian Chemical Society 26 9 (2015): 1824-1830. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941625728&partnerID=MN8TOARS.
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  36. Sá, D.S.; Fernandes, A.F.; Silva, C.D.S.; Costa, P.P.C.; Fonteles, M.C.; Nascimento, N.R.F.; Lopes, L.G.F.; Sousa, E.H.S.. "Non-nitric oxide based metallovasodilators: synthesis, reactivity and biological studies". Dalton Transactions 44 30 (2015): 13633-13640. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937458906&partnerID=MN8TOARS.
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  37. Sousa, Eduardo. "On the incorporation of Rhodamine B and 2',7'-dichlorofluorescein dyes in silica: Synthesis of fluorescent nanoparticles". Optical Materials (2014): http://dx.doi.org/10.1016/j.optmat.2014.02.028.
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  38. Silva Sousa, Eduardo Henrique; de Mesquita Vieira, Francisca Gilmara; Butler, Jennifer S.; Basso, Luiz Augusto; Santiago, Diogenes S.; Diogenes, Izaura C. N.; de Franca Lopes, Luiz Gonzaga; Sadler, Peter J.. "Fe(CN)(5)(isoniazid)(3-): An iron isoniazid complex with redox behavior implicated in tuberculosis therapy". Journal of Inorganic Biochemistry 140 (2014): 236-244. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000342608900029&KeyUID=WOS:000342608900029.
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  39. da Silva Junior, Jose Nunes; Sousa Lima, Mary Anne; Silva Sousa, Eduardo Henrique; Oliveira Alexandre, Francisco Serra; Melo Leite Junior, Antonio Jose. "KinChem: A Computational Resource for Teaching and Learning Chemical Kinetics". Journal of Chemical Education 91 12 (2014): 2203-2205. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346693900035&KeyUID=WOS:000346693900035.
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  40. Freire, R. M.; Longhinotti, E.; Sousa, E. H. S.; Fechine, P. B. A.. "Inorganic Nanoparticle Materials for Controlled Drug Delivery Systems". Bioengineered Nanomaterials (2014): https://publons.com/publon/10009063/.
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Capítulo de livro
  1. Sousa, Eduardo. "Escherichia coli DosC and DosP: a role of c-di-GMP in compartmentalized sensing by degradosomes". 2019.
    10.1016/bs.ampbs.2019.05.002
  2. Sousa, E. H. S.; Gilles-Gonzalez, M. A.. "Haem-Based Sensors of O-2: Lessons and Perspectives". editado por Poole, R. K., 235-257. 2017.
    10.1016/bs.ampbs.2017.05.001
Livro
  1. Silva, A.T.B.; Magalhães, J.L.; Sousa, E.H.S.; Da Silva, W.C.. Using supramolecular chemistry strategy for mapping electrochemical phenomena on the nanoscale. 2013.
    10.1007/978-3-642-29250-7_5
  2. Sousa, E.H.S.; Gonzalez, G.; Gilles-Gonzalez, M.-A.. Soluble guanylyl cyclase and its evolutionary relatives. 2008.
    10.1016/B978-044452839-1.50020-6
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018/03/02 - 2023/02/01 Investigações estruturais do sensor heme DevS
Orientador
 Química (Doutoramento)
Universidade Federal do Ceará, Brasil
2016/08/02 - 2020/07/01 Estudos funcionais e estruturais de heme proteínas como potenciais biocatalisadores
Orientador
 Química (Doutoramento)
Universidade Federal do Ceará, Brasil
2018/02/05 - 2020/01/26 Complexo heteroléptico de rutênio(II) acoplado à biotina ([Ru(bpy-anth)(bpy-biot)(dppz)](PF6)2): síntese, caracterização, estudos de reatividade e ensaios biológicos.
Orientador
 Química (Mestrado)
Universidade Federal do Ceará, Brasil
2017/08/05 - 2019/07/10 SÍNTESE, CARACTERIZAÇÃO E ESTUDOS DE REATIVIDADE DE NOVOS COMPOSTOS DE RUTÊNIO COM LIGANTES DERIVADOS TERPIRIDÍNICOS E BENZIMIDAZÓLICOS
Orientador
 Química (Mestrado)
Universidade Federal do Ceará, Brasil
2016/02/05 - 2018/12/05 Influência de ligantes, força iônica e pH sobre o potencial redox da proteína recombinante DevS do Mycobacterium tuberculosis
Coorientador
 Química (Mestrado)
Universidade Federal do Ceará, Brasil
2018/02/05 - 2018/07/05 Estudos espectroscópicos e cromatográficos da proteína recombinante DevS do Mycobacterium tuberculosis.
Orientador
 Química (Mestrado)
Universidade Federal do Ceará, Brasil
2013/02/05 - 2018/01/27 NITROSILO COMPLEXOS E ISONIAZIDA: REATIVIDADE E POTENCIAL BIOLÓGICO
Orientador
 Química (Doutoramento)
Universidade Federal do Ceará, Brasil
2013/06/01 - 2018/01/26 Desenvolvimento de novos complexos fosfínicos de rutênio com potencial anticâncer e bactericida
Orientador
 Química (Doutoramento)
Universidade Federal do Ceará, Brasil
2012/08/05 - 2017/01/20 Estudo espectroeletroquímico das hemeproteínas sensoras Rhizobium etli FixL e Mycobacterium tuberculosis DevS
Coorientador
 Química (Doutoramento)
Universidade Federal do Ceará, Brasil
2014/08/06 - 2016/07/05 FixL Híbrida da Bactéria Rhizobium etli: Estudos Conformacionais e de Estabilidade
Orientador
 Química (Mestrado)
Universidade Federal do Ceará, Brasil