???global.info.a_carregar???
Bruno Oliveira is an Assistant Researcher at C2TN-IST since 2023 funded by a prestigious FCT Stimulus Fellowship. He received his PhD in Nuclear Medicine, University of Lisbon in 2012. His interests are in the field of biomedical research, with an emphasis on the use of chemical probes and molecular imaging methods (PET, SPECT, fluorescence) to elucidate the molecular mechanisms of disease in living cells and/or subjects. His PhD work was focused on the identification of 99mTc SPECT probes for imaging Nitric Oxide Synthase overexpressed in specific tumor types, being the first example of metal complexes that recognize this enzyme. During his PhD Bruno visited the research groups of Francisco Blanco (CNIO, Madrid), Roger Alberto (University of Zurich) and Maria João Ramos (University of Porto), expanding his background to other scientific areas like protein expression and purification (J Mol Biol 2010, 396, 1117), organometallic (Org Biomol Chem 2010, 8, 2829) and computational chemistry (J Mol Graphics Modell 2013, 45, 13). After his PhD, Bruno Oliveira was a NIH Assistant Researcher at the MGH/Harvard Medical School (2013 - 2015) in the group of Peter Caravan. In the US his work led to the discovery of a Fibrin-Binding Probe for PET imaging of thrombus, which is currently under clinical studies. From 2015 to the end of 2018, Bruno was a Postdoctoral Fellow at Cambridge (UK) in the group of Gonçalo Bernardes sponsored by a prestigious Marie Curie Fellowship. His work focused on the development of new bioorthogonal reactions for biomedical applications. For example, in Cambridge, his work resulted in a significant breakthrough with the discovery of a cleavable reaction for prodrug activation, which is triggered by platinum complexes (JACS 2020, 142, 10869; inside cover). In 2019, Bruno secured his first FCT Stimulus Fellowship to join iMM. More recently, he was awarded with the same prestigious grant to start his own line of research at C2TN-IST. At the core of his work is the development of innovative strategies for modification of antibodies and small proteins for imaging and drug-delivery. Bruno´s scientific work until today resulted in 45 articles published in journals with an average IF of 11.1 (e.g. JACS, Angew Chem, Chem Sci, Nature Comm, JNM, Chem Soc Rev, Nature Rev Chem; >3300 citations; h-index 26), more than 50 scientific communications (20 invited oral communications, 6 conference articles, 25 posters), 4 cover articles, and 2 Alavi-Mandell awards. These publications are a good example of Bruno´s international recognition, and are a clear evidence of the various international collaborations that he currently maintain. Bruno was recently awarded with two research grants as PI to study new chemical methods to produce novel protein-drug conjugates (SIMICA, 800K €) and to detect GlycoRNA modifications in cancer biology (FCT, PTDC/MED-QUI/4160/2021, 249K €). The SIMICA project involved the participation of 5 European partners and intended to place Portugal within the core of European Laboratories that seeks to produce cutting-edge research in the field of protein modification. Bruno is participating or participated in 3 multidisciplinary FCT projects in the field of biomedicine. Since 2016 Bruno has been enrolled in teaching activities (Part IB chemistry teaching labs and Part III vivas at Cambridge). Until today he co-supervised more than 18 research projects of national or international master and PhD students. At C2TN Bruno has already supervised 2 MSc students (1 to completion and 1 ongoing), 1 first cycle project integrator student and 2 Erasmus students. Bruno has served as peer-reviewer in top journals, evaluator of EU research projects, examiner of PhD thesis, organizer of 4 scientific events, and chair in scientific meetings. Currently, Bruno is an objective driver of the thematic strand "Radiopharmaceutical Sciences and Health Physics" and responsible for the SPECT/PET-CT scanner at C2TN.
Identificação

Identificação pessoal

Nome completo
BRUNO LUÍS JESUS PINTO DE OLIVEIRA

Nomes de citação

  • Oliveira, Bruno L.

Identificadores de autor

Ciência ID
A016-1DDF-E7CB
ORCID iD
0000-0002-7687-4746
Google Scholar ID
http://scholar.google.com/citations?user=-Pk72DAAAAAJ&hl=en
Researcher Id
T-5374-2018
Scopus Author Id
24577505300

Endereços de correio eletrónico

  • bruno.oliveira@medicina.ulisboa.pt (Profissional)

Moradas

  • Av. Professor Egas Moniz, 1649-028 , Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Exatas - Química - Química Nuclear
  • Ciências Exatas - Química - Química Inorgânica
  • Ciências Exatas - Química - Química Orgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2007/11/01 - 2012/06/27
Concluído
Inorganic chemistry - radiopharmaceutical sciences (Doutoramento)
Especialização em Inorganic chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
"Re and 99mTc Organometallic Complexes for Targeting Nitric Oxide Synthase" (TESE/DISSERTAÇÃO)
Approved with distinction and honor by unanimity
2004/10/01 - 2006/10/01
Concluído
Biomedical inorganic chemistry (Mestrado)
Especialização em Inorganic chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
"New fac-[99mTc(CO)3]+ L-Arginine derivatives for detection of Nitric Oxide Synthase" (TESE/DISSERTAÇÃO)
19/20
1999/09/01 - 2004/09/01
Concluído
Chemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Inorganic Chemistry" (TESE/DISSERTAÇÃO)
15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/02/01 - Atual Assistente de Investigação (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
2015/03/01 - 2019/01/15 Pós-doutorado (Investigação) Cambridge University - Chemistry Department, Reino Unido
2013/01/01 - 2015/02/28 Assistente de Investigação (carreira) (Investigação) Athinoula A Martinos Center for Biomedical Imaging, Estados Unidos
Athinoula A Martinos Center for Biomedical Imaging, Estados Unidos
2010/06/01 - 2010/12/31 Investigador visitante (Investigação) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2010/01/03 - 2010/05/31 Investigador visitante (Investigação) University of Zurich Department of Chemistry, Suiça
University of Zurich Department of Chemistry, Suiça
2008/02/01 - 2008/06/30 Investigador visitante (Investigação) University of Zurich Department of Chemistry, Suiça
2005/05/28 - 2005/09/30 Investigador visitante (Investigação) Centro Nacional de Investigaciones Oncológicas, Espanha
Centro Nacional de Investigaciones Oncológicas, Espanha
Projetos

Bolsa

Designação Financiadores
2022/05/01 - 2025/04/30 Rapid mapping of glycoRNA using click chemistry and sequencing approaches
PTDC/MED-QUI/4160/2021
Investigador responsável
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/10 - 2022/10 Site-selective protein-modification chemistries for antibody-drug conjugates (ADCs)
Investigador responsável
Instituto de Medicina Molecular, Portugal
European Commission
2018/10 - 2021/10 Drug delivery of bioactive agents through selective decaging
PTDC/MED-QUI/28333/2017
Investigador
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
2018/10 - 2021/10 Intracellular Drug Delivery using Small Molecule Drug Conjugates for Prostate Cancer Therapy
PTDC/MED-QUI/28764/2017
Investigador
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
2018/08/01 - 2021/07/31 Novel Molecular Imaging tools for Cystic Fibrosis
PTDC/BTM-TEC/29256/2017
Bolseiro de Investigação
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/05/01 - 2018/09/30 Selective protein modification of antibody fragments targeting the Cystic Fibrosis transmembrane conductance regulator (CFTR) protein
FEBS Summer Fellowship
Orientador
Cambridge University - Chemistry Department, Reino Unido
Federation of European Biochemical Societies
Concluído
2016/02 - 2018/02 Collagen imaging in cells
702574
Investigador responsável
Cambridge University - Chemistry Department, Reino Unido
European Commission
2007/11 - 2012/06 FCT PhD Grant - Re and 99mTc Organometallic Complexes for Targeting Nitric Oxide Synthase
SFRH/BD/38753/2007
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2019/01/01 - 2025/01/01 Rationally Designed Bispecific antibodies for Brain-Targeted Delivery of Cancer Therapeutics
CEECIND/02335/2017
Investigador
Universidade de Lisboa Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em conferência
  1. Oliveira, Bruno L.. "A triple-isotope SPECT/PET-CT study with two novel fibrin-specific probes for non-invasive imaging of thrombus". Trabalho apresentado em SNMMI 2015 Annual Meeting, Baltimore, 2015.
    Publicado
  2. Oliveira, Bruno L.. "Molecular Imaging of Arterial and Deep Vein Thrombosis: Toward a Single-modality Approach for Thrombus Detection and Fibrin Content Estimation". Trabalho apresentado em American Heart Association's 2014 Scientific Sessions and Resuscitation Science Symposium, Chicago, 2014.
    Publicado
  3. Oliveira, Bruno L.. "Cystic Fibrosis: new molecular imaging tools". Trabalho apresentado em 16th European Cystic Fibrosis Basic Science Conference, Zurich, 2014.
    Publicado • https://doi.org/10.1007/s00775-014-1150-5
  4. Oliveira, Bruno L.. "In Vivo Molecular Imaging of Thrombosis and Thrombolysis Using a Fibrin-binding PET Probe". Trabalho apresentado em International Stroke Conference, 2014.
  5. Oliveira, Bruno L.. "Radiometalated L-Arginine derivatives for imaging nitric oxide synthase". Trabalho apresentado em 33rd European Peptide Symposium, Sofia, 2014.
    https://doi.org/10.1002/psc.2688
  6. Oliveira, Bruno L.. "2,3-Diamino propionic acid based chelators for labeling biomolecules with 99mTc(I)". Trabalho apresentado em International symposium on Technetium and other radiometals in chemistry and medicine, 2010.
    https://doi.org/10.1016/j.nucmedbio.2010.04.111
Artigo em revista
  1. Zawada, Zbigniew; Guo, Zijian; Oliveira, Bruno L.; Navo, Claudio D.; Li, He; Cal, Pedro M. S. D.; Corzana, Francisco; Jiménez-Osés, Gonzalo; Bernardes, Gonçalo J. L.. "Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions". Bioconjugate Chemistry 32 8 (2021): 1812-1822. http://dx.doi.org/10.1021/acs.bioconjchem.1c00276.
    10.1021/acs.bioconjchem.1c00276
  2. Ferreira, Vera F. C.; Oliveira, Bruno L.; D’Onofrio, Alice; Farinha, Carlos M.; Gano, Lurdes; Paulo, António; Bernardes, Gonçalo J. L.; Mendes, Filipa. "In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry". Bioconjugate Chemistry 32 1 (2020): 121-132. http://dx.doi.org/10.1021/acs.bioconjchem.0c00551.
    10.1021/acs.bioconjchem.0c00551
  3. Oliveira, Bruno L.; Stenton, Benjamin J.; Unnikrishnan, V. B.; de Almeida, Cátia Rebelo; Conde, João; Negrão, Magda; Schneider, Felipe S. S.; et al. "Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation". Journal of the American Chemical Society 142 24 (2020): 10869-10880. http://dx.doi.org/10.1021/jacs.0c01622.
    10.1021/jacs.0c01622
  4. Eloah Latocheski; Gean M. Dal Forno; Thuany M. Ferreira; Bruno L. Oliveira; Gonçalo J. L. Bernardes; Josiel B. Domingos. "Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions". Chemical Society Reviews (2020): https://doi.org/10.1039/D0CS00630K.
    10.1039/D0CS00630K
  5. Davies S; Qiao L; Oliveira B; Navo C; Jiménez-Osés G; Bernardes GJL. "Tetrazine-triggered release of carboxylic-acid containing molecules for activation of an anti-inflammatory drug.". Chembiochem : a European journal of chemical biology (2019): http://europepmc.org/abstract/med/30773780.
    10.1002/cbic.201900098
  6. Gil De Montes, E.; Jiménez-Moreno, E.; Oliveira, B.L.; Navo, C.D.; Cal, P.M.S.D.; Jiménez-Osés, G.; Robina, I.; Moreno-Vargas, A.J.; Bernardes, G.J.L.. "Azabicyclic vinyl sulfones for residue-specific dual protein labelling". Chemical Science 10 16 (2019): 4515-4522. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064611173&partnerID=MN8TOARS.
    10.1039/c9sc00125e
  7. Davies, S.; Oliveira, B.L.; Bernardes, G.J.L.. "Development of a self-immolative linker for tetrazine-triggered release of alcohols in cells". Organic and Biomolecular Chemistry 17 23 (2019): 5725-5730. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067259532&partnerID=MN8TOARS.
    10.1039/c9ob01167f
  8. Hoyt, E.A.; Cal, P.M.S.D.; Oliveira, B.L.; Bernardes, G.J.L.. "Contemporary approaches to site-selective protein modification". Nature Reviews Chemistry 3 3 (2019): 147-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062102884&partnerID=MN8TOARS.
    10.1038/s41570-019-0079-1
  9. Alcock, L.J.; Oliveira, B.L.; Deery, M.J.; Pukala, T.L.; Perkins, M.V.; Bernardes, G.J.L.; Chalker, J.M.. "Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells". ACS Chemical Biology 14 4 (2019): 594-598. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064812432&partnerID=MN8TOARS.
    10.1021/acschembio.8b01104
  10. Sarah Davies; Bruno L. Oliveira; Gonçalo J. L. Bernardes. "Development of a self-immolative linker for tetrazine-triggered release of alcohols in cells". Organic & Biomolecular Chemistry (2019): https://doi.org/10.1039/C9OB01167F.
    10.1039/C9OB01167F
  11. Zwicker VE; Oliveira BL; Yeo JH; Fraser ST; Bernardes GJL; New EJ; Jolliffe KA. "A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism.". Angewandte Chemie (International ed. in English) (2018): http://europepmc.org/abstract/med/30548909.
    10.1002/anie.201812489
  12. Ferreira VFC; Oliveira BL; Santos JD; Correia JDG; Farinha CM; Mendes FF. "Targeting of the cystic fibrosis transmembrane conductance regulator (CFTR) protein with a technetium-99m imaging probe.". ChemMedChem (2018): http://europepmc.org/abstract/med/29864241.
    10.1002/cmdc.201800187
  13. Stenton BJ; Oliveira BL; Matos MJ; Sinatra L; Bernardes GJL. "A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging.". Chemical science (2018): http://europepmc.org/abstract/med/29780549.
    10.1039/c8sc00256h
  14. Matos MJ; Oliveira BL; Martínez-Sáez N; Guerreiro A; Cal PMSD; Bertoldo J; Maneiro M; et al. "Chemo- and Regioselective Lysine Modification on Native Proteins.". Journal of the American Chemical Society (2018): http://europepmc.org/abstract/med/29473744.
    10.1021/jacs.7b12874
  15. Sun, S.; Oliveira, B.L.; Jiménez-Osés, G.; Bernardes, G.J.L.. "Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells". Angewandte Chemie - International Edition 57 48 (2018): 15832-15835. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055950141&partnerID=MN8TOARS.
    10.1002/anie.201811338
  16. Benjamin J. Stenton; Bruno L. Oliveira; Maria J. Matos; Laura Sinatra; Gonçalo J. L. Bernardes. "A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging". Chemical Science 9 17 (2018): 4185-4189. https://doi.org/10.1039/C8SC00256H.
    10.1039/C8SC00256H
  17. Dos Santos Ferreira D; Jesus de Oliveira Pinto BL; Kumar V; Cardoso VN; Fernandes SO; Souza CM; Cassali GD; et al. "Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice.". Nanomedicine : nanotechnology, biology, and medicine (2017): http://europepmc.org/abstract/med/28343016.
    10.1016/j.nano.2017.03.005
  18. Morais M; Ferreira VFC; Figueira F; Mendes F; Raposinho P; Santos I; Oliveira BL; Correia JDG. "Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters.". (2017): http://europepmc.org/abstract/med/28612866.
    10.1039/c7dt01146f
  19. Bruno L. Oliveira; Peter Caravan. "Peptide-based fibrin-targeting probes for thrombus imaging". Dalton Transactions 46 42 (2017): 14488-14508. https://doi.org/10.1039/C7DT02634J.
    10.1039/C7DT02634J
  20. Maurício Morais; Vera F. C. Ferreira; Flávio Figueira; Filipa Mendes; Paula Raposinho; Isabel Santos; Bruno L. Oliveira; João D. G. Correia. "Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters". Dalton Transactions 46 42 (2017): 14537-14547. https://doi.org/10.1039/C7DT01146F.
    10.1039/C7DT01146F
  21. Waghorn, P.A.; Oliveira, B.L.; Jones, C.M.; Tager, A.M.; Caravan, P.. "High sensitivity HPLC method for determination of the allysine concentration in tissue by use of a naphthol derivative". Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1064 (2017): 7-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028694988&partnerID=MN8TOARS.
    10.1016/j.jchromb.2017.08.032
  22. Jiménez-Moreno, E.; Guo, Z.; Oliveira, B.L.; Albuquerque, I.S.; Kitowski, A.; Guerreiro, A.; Boutureira, O.; et al. "Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells". Angewandte Chemie - International Edition 56 1 (2017): 243-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006386992&partnerID=MN8TOARS.
    10.1002/anie.201609607
  23. Oliveira, B.L.; Guo, Z.; Bernardes, G.J.L.. "Inverse electron demand Diels-Alder reactions in chemical biology". Chemical Society Reviews 46 16 (2017): 4895-4950. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027397427&partnerID=MN8TOARS.
    10.1039/c7cs00184c
  24. Oliveira, B.L.; Caravan, P.. "Peptide-based fibrin-targeting probes for thrombus imaging". Dalton Transactions 46 42 (2017): 14488-14508. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032625401&partnerID=MN8TOARS.
    10.1039/c7dt02634j
  25. Oliveira BL; Guo Z; Boutureira O; Guerreiro A; Jiménez-Osés G; Bernardes GJ. "A Minimal, Unstrained S-Allyl Handle for Pre-Targeting Diels-Alder Bioorthogonal Labeling in Live Cells.". Angewandte Chemie International Edition in English (2016): http://europepmc.org/abstract/med/27763724.
    10.1002/anie.201608438
  26. Bernardim B; Cal PM; Matos MJ; Oliveira BL; Martínez-Sáez N; Albuquerque IS; Perkins E; et al. "Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents.". Nature Communications (2016): http://europepmc.org/abstract/med/27782215.
    10.1038/ncomms13128
  27. Ferreira Ddos S; Faria SD; Lopes SC; Teixeira CS; Malachias A; Magalhães-Paniago R; de Souza Filho JD; et al. "Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity, and biodistribution evaluation in a mouse model of bone metastasis.". International journal of nanomedicine (2016): http://europepmc.org/abstract/med/27563241.
    10.2147/ijn.s109966
  28. Oliveira BL; Blasi F; Rietz TA; Rotile NJ; Day H; Caravan P. "Multimodal molecular imaging reveals high target uptake and specificity of 111In and 68Ga labeled fibrin-binding probes for thrombus detection in rats.". Journal of Nuclear Medicine (2015): http://europepmc.org/abstract/med/26251420.
    10.2967/jnumed.115.160754
  29. Blasi F; Oliveira BL; Rietz TA; Rotile NJ; Naha PC; Cormode DP; Izquierdo-Garcia D; Catana C; Caravan P. "Multisite Thrombus Imaging and Fibrin Content Estimation With a Single Whole-Body PET Scan in Rats.". Arteriosclerosis, Thrombosis, and Vascular Biology (2015): http://europepmc.org/abstract/med/26272938.
    10.1161/ATVBAHA.115.306055
  30. Blasi F; Oliveira BL; Rietz TA; Rotile NJ; Day H; Naha PC; Cormode DP; et al. "Radiation Dosimetry of the Fibrin-Binding Probe 64Cu-FBP8 and Its Feasibility for PET Imaging of Deep Vein Thrombosis and Pulmonary Embolism in Rats.". Journal of Nuclear Medicine (2015): http://europepmc.org/abstract/med/25977464.
    10.2967/jnumed.115.157982
  31. Oliveira BL; Morais M; Mendes F; Moreira IS; Cordeiro C; Fernandes PA; Ramos MJ; et al. "Re(I) and Tc(I) Complexes for Targeting Nitric Oxide Synthase: Influence of the Chelator in the Affinity for the Enzyme.". Chemical Biology & Drug Design (2015): http://europepmc.org/abstract/med/25894011.
    10.1111/cbdd.12575
  32. Amgarten B; Rajan R; Martínez-Sáez N; Oliveira BL; Albuquerque IS; Brooks RA; Reid DG; Duer MJ; Bernardes GJ. "Collagen labelling with an azide-proline chemical reporter in live cells.". Chemical Communications (London) (2014): http://europepmc.org/abstract/med/25415185.
    10.1039/c4cc07974d
  33. Ay I; Blasi F; Rietz TA; Rotile NJ; Kura S; Brownell AL; Day H; et al. "In vivo molecular imaging of thrombosis and thrombolysis using a fibrin-binding positron emission tomographic probe.". Circulation Cardiovascular Imaging (2014): http://europepmc.org/abstract/med/24777937.
    10.1161/CIRCIMAGING.113.001806
  34. Oliveira BL; Morais M; Gano L; Santos I; Correia JD. "A 99mTc(CO)3 -labeled benzylguanidine with persistent heart uptake.". Journal of Labelled Compounds and Radiopharmaceuticals (2014): http://europepmc.org/abstract/med/24861983.
    10.1002/jlcr.3188
  35. Blasi F; Oliveira BL; Rietz TA; Rotile NJ; Day H; Looby RJ; Ay I; Caravan P. "Effect of Chelate Type and Radioisotope on the Imaging Efficacy of 4 Fibrin-Specific PET Probes.". Journal of Nuclear Medicine (2014): http://europepmc.org/abstract/med/24790217.
    10.2967/jnumed.113.136275
  36. Oliveira BL; Moreira IS; Fernandes PA; Ramos MJ; Santos I; Correia JD. "Theoretical studies on the binding of rhenium(I) complexes to inducible nitric oxide synthase.". Journal of Molecular Graphics and Modelling (2013): http://europepmc.org/abstract/med/23995452.
    10.1016/j.jmgm.2013.07.007
  37. Oliveira BL; Moreira IS; Fernandes PA; Ramos MJ; Santos I; Correia JD. "Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms.". Journal of Molecular Modeling (2013): http://europepmc.org/abstract/med/23263357.
    10.1007/s00894-012-1677-8
  38. Morais M; Oliveira BL; Correia JD; Oliveira MC; Jiménez MA; Santos I; Raposinho PD. "Influence of the bifunctional chelator on the pharmacokinetic properties of 99mTc(CO)3-labeled cyclic a-melanocyte stimulating hormone analog.". Journal of Medicinal Chemistry (2013): http://europepmc.org/abstract/med/23414214.
    10.1021/jm301647t
  39. De Almeida, A.; Oliveira, B.L.; Correia, J.D.G.; Soveral, G.; Casini, A.. "Emerging protein targets for metal-based pharmaceutical agents: An update". Coordination Chemistry Reviews 257 19-20 (2013): 2689-2704. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882843820&partnerID=MN8TOARS.
    10.1016/j.ccr.2013.01.031
  40. Palma, E.; Correia, J.D.G.; Oliveira, B.L.; Gano, L.; Santos, I.C.; Santos, I.. "99mTc(CO)3-labeled pamidronate and alendronate for bone imaging". Dalton Transactions 40 12 (2011): 2787-2796. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952647633&partnerID=MN8TOARS.
    10.1039/c0dt01396j
  41. Oliveira, B.L.; Raposinho, P.D.; Mendes, F.; Santos, I.C.; Santoes, I.; Ferreira, A.; Cordeiro, C.; Freire, A.P.; Correia, J.D.G.. "Targeting nitric oxide synthase with 99mTc/Re-tricarbonyl complexes containing pendant guanidino or isothiourea moieties". Journal of Organometallic Chemistry 696 5 (2011): 1057-1065. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952194212&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2010.09.019
  42. Oliveira BL; Raposinho PD; Mendes F; Figueira F; Santos I; Ferreira A; Cordeiro C; Freire AP; Correia JD. "Re and Tc tricarbonyl complexes: from the suppression of NO biosynthesis in macrophages to in vivo targeting of inducible nitric oxide synthase.". Journal of the Chemical Society Dalton Transactions (2010): http://europepmc.org/abstract/med/21043515.
    10.1021/bc100291e
  43. Liu Y; Oliveira BL; Correia JD; Santos IC; Santos I; Spingler B; Alberto R. "Syntheses of bifunctional 2,3-diamino propionic acid-based chelators as small and strong tripod ligands for the labelling of biomolecules with (99m)Tc.". Organic & Biomolecular Chemistry (2010): http://europepmc.org/abstract/med/20445942.
    10.1039/c002796k
  44. Palacios A; Moreno A; Oliveira BL; Rivera T; Prieto J; García P; Fernández-Fernández MR; et al. "The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin.". Journal of Molecular Biology (2010): http://europepmc.org/abstract/med/20053357.
    10.1016/j.jmb.2009.12.049
  45. Oliveira BL; Correia JD; Raposinho PD; Santos I; Ferreira A; Cordeiro C; Freire AP. "Re and (99m)Tc organometallic complexes containing pendant l-arginine derivatives as potential probes of inducible nitric oxide synthase.". Journal of the Chemical Society Dalton Transactions (2009): http://europepmc.org/abstract/med/19081984.
    10.1039/b805986a
  46. Palma E; Oliveira BL; Correia JD; Gano L; Maria L; Santos IC; Santos I. "A new bisphosphonate-containing (99m)Tc(I) tricarbonyl complex potentially useful as bone-seeking agent: synthesis and biological evaluation.". Journal of Biological Inorganic Chemistry (2007): http://europepmc.org/abstract/med/17333301.
    10.1007/s00775-007-0215-0
  47. Palma, E.; Oliveira, B.L.; Figueira, F.; Correia, J.D.G.; Raposinho, P.D.; Santos, I.. "A pyrazolylamine-phosphonate monoester chelator for the fac-[M(CO)3 core (M = Re, 99mTc): Synthesis, coordination properties and biological assessment". Journal of Labelled Compounds and Radiopharmaceuticals 50 13 (2007): 1176-1184. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949087577&partnerID=MN8TOARS.
    10.1002/jlcr.1415
Website
  1. Oliveira, Bruno L.. BioImaging and Targeting. 2019. https://bioimagingtargeting.weebly.com/.

Outros

Outra produção
  1. Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo - ChemRxiv. 2018. Stenton B; Oliveira B; Conde J; Negrão M; Godinho Ferreira M; Fior R; Bernardes G. http://europepmc.org/abstract/PPR/PPR61887.
    10.26434/chemrxiv.7327904
  2. Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells. 2018. Alcock L; Oliveira B; Deery M; Pukala T; Perkins M; Bernardes G; Chalker J. http://europepmc.org/abstract/PPR/PPR63300.
    10.26434/chemrxiv.7396958
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/02/14 Methods for protein modification and their biological applications". Lisbon BioMed day
2021/10/14 The tale of cysteine bioconjugation ACORN workshop
IMM (Praia verde, Portugal)
2021/07/14 Chemical modifications of proteins and their applications C2TN open day
Radiopharmaceutic science group (Lisboa, Portugal)
2019/01/04 Diels-Alder click reactions for chemical biology applications Chemistry and Biology CrossTalks 2019
Pedro Góis (Lisboa, Portugal)
2018/11/04 From bioorthogonal chemistry to chemical physiology of antibody conjugates and natural products; Scientific retreat of Hagan Bayley group
Hagan Bayley (Lisbon, Portugal)
2017/05/16 Molecular Imaging of Disease Chemistry Departmental-wide lectures series, Cambridge University, UK
Cambridge University (Cambridge, Reino Unido)
2016/09/04 Thrombus imaging: how to hunt a serial killer YES (Young European Scientist) Meeting
YES meeting comittee (Porto, Portugal)
2015/06/08 A Triple-isotope SPECT/PET-CT Study With Two Novel Fibrin-Specific Probes for Non-Invasive Imaging of Thrombus SNMMI 2015 Annual Meeting
SNMMI (Baltimore, Estados Unidos)
2011/03/08 Structural determinants for targeting iNOS with 99mTc/Re complexes EU COST Action D38
Stephen Faulkner (Oxford, Reino Unido)
2010/10/12 Technetium-99m complexes of l-arginine derivatives for targeting iNOS 1st PYCHEM
Portuguese Chemistry Society (Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2022/03/01 - 2022/10/31 Protein conjugates targeting the epithelial cellular adhesion molecule for combined imaging and chemo-therapy
Orientador
Master degree (Licenciatura/Bacharelato)
Centro de Ciências e Tecnologias Nucleares, Portugal
2022/02/13 - 2022/05/31 A chemical approach for modification of de novo proteins targeting the PD-L1 receptor for imaging and chemotherapy
Orientador
PhD (Doutoramento)
Universidade de Santiago de Compostela, Espanha
2019/05/01 - 2020/03/01 Platinum-triggered Bioorthogonal Decaging for Targeted-Drug Activation in vivo
Coorientador
Master (Doutoramento)
Instituto de Medicina Molecular, Portugal
2018/01/01 - 2018/11/30 Indium mediated reactions for protein modification
Coorientador
PhD (Doutoramento)
Cambridge University - Chemistry Department, Reino Unido
2018/01/01 - 2018/11/30 Norbornene probes for the detection of cysteine sulfenic acid in cells
Coorientador
PhD (Doutoramento)
Cambridge University - Chemistry Department, Reino Unido
2018/01/01 - 2018/11/30 Azabicyclic vinyl sulfones for residue-specific dual protein labeling
Coorientador
PhD (Doutoramento)
Cambridge University - Chemistry Department, Reino Unido
2018/01/01 - 2018/11/30 Tetrazine-triggered release of carboxylic-acid containing molecules for activation of an anti-inflammatory drug
Coorientador
Master (Mestrado)
Cambridge University - Chemistry Department, Reino Unido
2017/01/01 - 2018/01/01 Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells
Coorientador
PhD (Doutoramento)
Cambridge University - Chemistry Department, Reino Unido
2017/01/01 - 2018/01/01 Tetrazine-triggered release of carboxylic-acid containing molecules for activation of an anti-inflammatory drug
Coorientador
PhD (Doutoramento)
Cambridge University - Chemistry Department, Reino Unido
2016/01/01 - 2017/01/01 Vinyl ether–tetrazine pair for the traceless release of alcohols in cells
Coorientador
PhD (Iniciação científica)
Cambridge University - Chemistry Department, Reino Unido
2016/01/01 - 2017/01/01 Thioether-directed Palladium-cleavable Linker for Targeted Bioorthogonal Drug Decaging
Coorientador
PhD (Doutoramento)
Cambridge University - Chemistry Department, Reino Unido
2016/05/01 - 2016/10/31 A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism
Coorientador
PhD (Doutoramento)
Cambridge University - Chemistry Department, Reino Unido
2015/03/01 - 2016/03/01 Collagen labelling with an azide-proline chemical reporter in live cells
Coorientador
Master (Mestrado)
University of Cambridge Department of Chemistry, Reino Unido
2016/01/01 - 2016/01/01 A minimal, unstrained S-allyl handle for pretargeting Diels–Alder bioorthogonal labelling in live cells
Coorientador
PhD (Doutoramento)
University of Cambridge Department of Chemistry, Reino Unido
2013/09/01 - 2014/09/01 Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice
Coorientador
PhD (Iniciação científica)
Athinoula A Martinos Center for Biomedical Imaging, Estados Unidos
2008/09/01 - 2009/09/01 Re and Tc Tricarbonyl Complexes: From the Suppression of NO Biosynthesis in Macrophages to in Vivo Targeting of Inducible Nitric Oxide Synthase
Coorientador
Master (Mestrado)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2020/02/11 - 2020/02/11 IMM Postdoc Day 2020 (2020/02/11 - 2020/02/11)
Encontro (Membro da Comissão Organizadora)
Instituto de Medicina Molecular, Portugal
2019/11/14 - 2019/11/15 Lisbon Area Postdoc Meeting 2019 (2019/11/14 - 2019/11/15)
Encontro (Membro da Comissão Organizadora)
Instituto de Medicina Molecular, Portugal
2014/06/25 - 2014/06/25 Networking event PAPS & Madrid-MIT M+Visión (2014/06/25 - 2014/06/25)
Encontro (Membro da Comissão Organizadora)
Athinoula A Martinos Center for Biomedical Imaging, Estados Unidos
2013/05/10 - 2013/05/10 XV PAPS Forum 2013 (2013/05/10 - 2013/05/10)
Festival (Membro da Comissão Organizadora)
Portuguese American Postgraduate Society , Estados Unidos

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2020/02/28 - 2020/02/28 Rodent Necropsy Workshop 2020
Oficina (workshop)
Animal experimentation course
Instituto Gulbenkian de Ciência, Portugal
2020/02/11 - 2020/02/11 Chair of a scientific session at IMM Postdoc Day 2020, Lisboa, Portugal
Encontro
IMM Postdoc Day 2020
Instituto de Medicina Molecular, Portugal
2019/11/05 - 2019/11/06 Laboratory Animal Sciences Course 2019
Oficina (workshop)
FELASA Category B course
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2019/10/14 - 2019/10/14 Chair of the session “La Caixa Funding Scheme“ at Lisbon Area Postdoc Meeting 2019, Lisboa, Portugal
Encontro
Lisbon Area Postdoc Meeting 2019
Instituto de Medicina Molecular, Portugal
2016/09/04 - 2016/09/09 Hands-on training course in techniques of confocal microscopy
Oficina (workshop)
Confocal Microscopy Course
University of York Department of Biology, Reino Unido
2011/06/05 - 2011/06/10 AMBER software workshop
Oficina (workshop)
Theoretical and computational course
Centro Nacional de Supercomputación, Espanha
2008/06/15 - 2008/07/15 Zürich School of Crystallography. Bring Your Own Crystals
Oficina (workshop)
Universität Zurich Biochemisches Institut, Suiça

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2018/06/15 Indium-111 based complexes bearing specific peptides for cancer theranostics
Arguente principal
Filipe Vultos (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2020/02/11 - 2020/02/11 IMM Postdoc day IMM
2019/10/14 - 2019/10/15 Lisbon Area Postdoc Meeting 2019 Lisbon Postdoc Association

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2018/09/24 - 2018/09/28 Chemistry Showcase Week Jury of Poster awards
Avaliador
Cambridge University - Chemistry Department, Reino Unido

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2017/01/01 - 2018/11/30 Tutor for Part IB chemistry teaching labs (Bachelor) University of Cambridge Department of Chemistry, Reino Unido
2017/01/01 - 2018/11/30 Assessor of Rota projects from EPSRC Synthetic Biology, Centre for Doctoral Training (Doktor (PhD)) Cambridge University - Chemistry Department, Reino Unido
2016/01/01 - 2018/11/30 Examiner of Part III projects (Master) Cambridge University - Chemistry Department, Reino Unido
2015/03/01 - 2016/12/31 Demonstrator for Part IB chemistry teaching labs (Bachelor) University of Cambridge Department of Chemistry, Reino Unido

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2015/10/13 New methods for detection of thrombus Jornal Público

Membro de associação

Nome da associação Tipo de participação
2021 - Atual Royal society of chemistry Member of the Royal society of chemistry
2019/01/01 - Atual IMM Postdoc Association Member of the executive committee of the IMM PDA
2018/01/01 - 2018/12/31 Clare Hall College Fellow
2013/09/01 - 2014/12/31 Vice-President of the Portuguese-American Post-graduate Society Vice-President

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2019/09/04 - 2019/12/05 Reviewer of Marie Sklodowska-Curie Actions European Union, Bélgica
2019/09/15 - 2019/11/30 Reviewer for EU projects European Union, Bélgica
2019/09/17 - 2019/09/17 Assessor of the project “Site-selective antibody modification using carbonylacrylic reagents for imaging of CFTR protein in Cystic Fibrosis” for the course Advanced Experimental Techniques and Methodologies in Biotechnology at Instituto Superior Técnico Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/06/01 - 2018/12/31 Administrator of the cell culture facility and epifluorescence microscopy of the Centre for Biological Chemistry, Chemistry Department, Cambridge University Cambridge University - Chemistry Department, Reino Unido

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2020/03/01 - Atual Chemical science RSC
2019/02/03 - Atual Journal of Nuclear Medicine (2159-662X) Society of Nuclear Medicine
2018/11/13 - Atual Theranostics (1838-7640) Ivyspring International Publisher
2018/02/06 - Atual Organic & Biomolecular Chemistry (1477-0539) The Royal Society of Chemistry
2015/08/20 - Atual Bioorganic & Medicinal Chemistry (0968-0896) Elsevier
2015/02/15 - Atual Journal of Enzyme Inhibition and Medicinal Chemistry Taylor & Francis Online

Tutoria

Tópico Nome do aluno
2021 - Atual Mentoring program for resident doctors Larissa Dornelles
Distinções

Prémio

2020 Inside cover paper at JACS 2020
2019 Scientific Meeting Grant
The Company of Biologists, Reino Unido
2018 Assistant Researcher: FCT Stimulus of Scientific Employment
Fundação para a Ciência e a Tecnologia, Portugal
2015 Alavi-Mandell award for best paper published in 2015 at JNM (2015, 56, 1088)
Society of Nuclear Medicine and Molecular Imaging, Estados Unidos
2015 Alavi-Mandell award for best paper published in 2015 at JNM (2015, 56, 1587)
Society of Nuclear Medicine and Molecular Imaging, Estados Unidos
2014 Best poster prize at Pfizer Symposium 2014 “Collagen labelling with an azide-proline chemical reporter in live cells
University of Cambridge Department of Chemistry, Reino Unido
2013 Traveling fellowship to attend the Gordon Conference - Metals in Medicine 2013, NH, USA.
Gordon Research Conferences, Estados Unidos
2007 PhD Fellowship - National Science Foundation Portugal - PhD Grant (FCT, SFRH/BD/38753/2007)
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2017 Inside cover paper at Dalton Trans 2017
Royal Society of Chemistry, Reino Unido
2017 Inside cover paper at Chem Soc Rev 2017
Royal Society of Chemistry, Reino Unido
2016 Cover paper at Arteriosclerosis, Thrombosis, and Vascular Biology 2016
American Heart Association Inc, Estados Unidos