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Identificação

Identificação pessoal

Nome completo
Gabriela Martinho de Almeida

Identificadores de autor

Ciência ID
A016-D031-3648

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Oncologia
  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Médicas e da Saúde - Medicina Básica - Toxicologia
Formação
Grau Classificação
2006
Concluído
 PhD degree (Doutoramento)
University of Leicester, Reino Unido
"Analysis of DNA damage and cellular responses to platinum-based chemotherapeutic agents in ‘in vitro’ models of non-small cell lung cancer" (TESE/DISSERTAÇÃO)
 Honours
2000
Concluído
 Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/10 - Atual Investigador (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2008/04/01 - 2021/04/30 Investigador Contratado (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Outras Carreiras

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/05/01 - Atual Técnico Superior (Técnico Superior) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Affiliated Professor Pathology Department, Medical Faculty, University of Porto, Portugal
2005/10/01 - 2008/03/31 Assistant Researcher University of Leicester, Reino Unido
Produções

Publicações

Artigo em conferência
  1. Solorzano, L.; Almeida, G.M.; Mesquita, B.; Martins, D.; Oliveira, C.; Wählby, C.. "Whole Slide Image Registration for the Study of Tumor Heterogeneity". 2018.
    10.1007/978-3-030-00949-6_12
Artigo em revista
  1. Santos, M.; Fidalgo, A.; Varanda, A.S.; Soares, A.R.; Almeida, G.M.; Martins, D.; Mendes, N.; Oliveira, C.; Santos, M.A.S.. "Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells". Frontiers in Molecular Biosciences 9 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130283309&partnerID=MN8TOARS.
    10.3389/fmolb.2022.809985
  2. Pereira, C.; Park, J.-H.; Campelos, S.; Gullo, I.; Lemos, C.; Solorzano, L.; Martins, D.; et al. "Comparison of East-Asia and West-Europe cohorts explains disparities in survival outcomes and highlights predictive biomarkers of early gastric cancer aggressiveness". International Journal of Cancer 150 5 (2022): 868-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-85121371701&partnerID=MN8TOARS.
    10.1002/ijc.33872
  3. Gabriela M Almeida; Carla Pereira; Ji-Hyeon Park; Carolina Lemos; Sofia Campelos; Irene Gullo; Diana Martins; et al. "CD44v6 High Membranous Expression Is a Predictive Marker of Therapy Response in Gastric Cancer Patients". Biomedicines (2021): https://doi.org/10.3390/biomedicines9091249.
    10.3390/biomedicines9091249
  4. Leslie Solorzano; Carla Pereira; Diana Martins; Raquel Almeida; Fatima Carneiro; Gabriela M. Almeida; Carla Oliveira; Carolina Wahlby. "Towards Automatic Protein Co-Expression Quantification in Immunohistochemical TMA Slides". IEEE Journal of Biomedical and Health Informatics (2021): 1-1. https://doi.org/10.1109/JBHI.2020.3008821.
    10.1109/JBHI.2020.3008821
  5. Sara Rocha; Afonso P Basto; Marieke E Ijsselsteijn; Sara P Teles; Maria M Azevedo; Gilza Gonçalves; Irene Gullo; et al. "Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development". Cancers (2021): https://doi.org/10.3390/cancers13030421.
    10.3390/cancers13030421
  6. Nunes, M.; Silva, P.M.A.; Coelho, R.; Pinto, C.; Resende, A.; Bousbaa, H.; Almeida, G.M.; Ricardo, S.. "Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein". Frontiers in Oncology 11 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118608070&partnerID=MN8TOARS.
    10.3389/fonc.2021.752127
  7. Silvana Lobo; Carla Pereira; Carla Oliveira; Gabriela M. Almeida. "Skipping Exon-v6 from CD44v6-Containing Isoforms Influences Chemotherapy Response and Self-Renewal Capacity of Gastric Cancer Cells". Cancers (2020): https://doi.org/10.3390/cancers12092378.
    10.3390/cancers12092378
  8. Carla Pereira; Daniel Ferreira; Nuno Mendes; Pedro L. Granja; Gabriela M. Almeida; Carla Oliveira. "Expression of CD44v6-Containing Isoforms Influences Cisplatin Response in Gastric Cancer Cells". Cancers (2020): https://doi.org/10.3390/cancers12040858.
    10.3390/cancers12040858
  9. Gullo, I.; Oliveira, P.; Athelogou, M.; Gonçalves, G.; Pinto, M.L.; Carvalho, J.; Valente, A.; et al. "New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression". Gastric Cancer 22 1 (2019): 77-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047119532&partnerID=MN8TOARS.
    10.1007/s10120-018-0836-8
  10. Gullo, I.; Carneiro, F.; Oliveira, C.; Almeida, G.M.. "Heterogeneity in Gastric Cancer: From Pure Morphology to Molecular Classifications". Pathobiology 85 1-2 (2018): 50-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021073873&partnerID=MN8TOARS.
    10.1159/000473881
  11. Korsak, B.; Almeida, G.M.; Rocha, S.; Pereira, C.; Mendes, N.; Osório, H.; Pereira, P.M.R.; et al. "Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic therapy of gastric cancer". International Journal of Cancer 141 7 (2017): 1478-1489. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022335625&partnerID=MN8TOARS.
    10.1002/ijc.30844
  12. Coelho, S.C.; Almeida, G.M.; Pereira, M.C.; Santos-Silva, F.; Coelho, M.A.N.. "Functionalized gold nanoparticles improve afatinib delivery into cancer cells". Expert Opinion on Drug Delivery 13 1 (2016): 133-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955199883&partnerID=MN8TOARS.
    10.1517/17425247.2015.1083973
  13. Coelho, S.C.; Almeida, G.M.; Santos-Silva, F.; Pereira, M.C.; Coelho, M.A.N.. "Enhancing the efficiency of bortezomib conjugated to pegylated gold nanoparticles: an in vitro study on human pancreatic cancer cells and adenocarcinoma human lung alveolar basal epithelial cells". Expert Opinion on Drug Delivery 13 8 (2016): 1075-1081. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965081654&partnerID=MN8TOARS.
    10.1080/17425247.2016.1178234
  14. Frasco, M.F.; Almeida, G.M.; Santos-Silva, F.; Do Carmo Pereira, M.; Coelho, M.A.N.. "Transferrin surface-modified PLGA nanoparticles-mediated delivery of a proteasome inhibitor to human pancreatic cancer cells". Journal of Biomedical Materials Research - Part A 103 4 (2015): 1476-1484. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923600004&partnerID=MN8TOARS.
    10.1002/jbm.a.35286
  15. Queirós, P.; Pinheiro, H.; Carvalho, J.; Oliveira, P.; Gullo, I.; Carneiro, F.; Almeida, G.M.; Oliveira, C.. "KRAS mutations in microsatellite instable gastric tumours: impact of targeted treatment and intratumoural heterogeneity". Virchows Archiv 467 4 (2015): 383-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944513629&partnerID=MN8TOARS.
    10.1007/s00428-015-1823-7
  16. Duraes, Cecilia; Almeida, Gabriela M.; Seruca, Raquel; Oliveira, Carla; Carneiro, Fatima. "Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?". Virchows Archiv 464 3 (2014): 367-378.
    10.1007/s00428-013-1533-y
  17. Almeida, G.M.; Lima, R.T.; Seca, H.; Vasconcelos, M.H.; Bergantim, R.; Guimarães, J.E.; Sobrinho-Simões, M.. "Effect of miR-128 in DNA damage of HL-60 acute myeloid leukemia cells". Current Pharmaceutical Biotechnology 15 5 (2014): 492-502. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907184167&partnerID=MN8TOARS.
  18. Freitas, Daniela P.; Teixeira, Cristina A.; Santos-Silva, Filipe; Vasconcelos, M. Helena; Almeida, Gabriela M.. "Therapy-induced enrichment of putative lung cancer stem-like cells". International Journal of Cancer 134 6 (2013): 1270-1278. http://dx.doi.org/10.1002/ijc.28478.
    10.1002/ijc.28478
  19. dos Santos, Tiago; Tavares, Catarina; Sousa, Diana; Vaz, Josiana A.; Calhelha, Ricardo C.; Martins, Anabela; Almeida, Gabriela M.; Ferreira, Isabel C. F. R.; Helena Vasconcelos, M.. "Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line". Food Research International 53 1 (2013): 476-481.
    10.1016/j.foodres.2013.05.037
  20. Coelho, Silvia Castro; Rocha, Sandra; Juzenas, Petras; Sampaio, Paula; Almeida, Gabriela M.; Silva, Filipe Santos; Pereira, Maria Carmo; Coelho, Manuel A. N.. "Gold nanoparticle delivery-enhanced proteasome inhibitor effect in adenocarcinoma cells". Expert Opinion on Drug Delivery 10 10 (2013): 1345-1352.
    10.1517/17425247.2013.827659
  21. Seca, H.; Lima, R.T.; Lopes-Rodrigues, V.; Guimarães, J.E.; Almeida, G.M.; Vasconcelos, M.H.. "Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells". Current Drug Targets 14 10 (2013): 1135-1143. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881353774&partnerID=MN8TOARS.
    10.2174/13894501113149990185
  22. Cazal, C.M.; Choosang, K.; Severino, V.G.P.; Fernandes, J.B.; da Silva, M.F.G.F.; Vieira, P.C.; Nascimento, M.S.J.; et al. "Natural compounds with cell growth inhibitory activity in human tumor cell lines". Anti-Cancer Agents in Medicinal Chemistry 13 10 (2013): 1582-1589. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898928442&partnerID=MN8TOARS.
    10.2174/1871520613666131125122857
  23. Vaz, J.A.; Ferreira, I.C.F.R.; Tavares, C.; Almeida, G.M.; Martins, A.; Helena Vasconcelos, M.. "Suillus collinitus methanolic extract increases p53 expression and causes cell cycle arrest and apoptosis in a breast cancer cell line". Food Chemistry 135 2 (2012): 596-602. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863914727&partnerID=MN8TOARS.
    10.1016/j.foodchem.2012.04.127
  24. Vaz, J.A.; Almeida, G.M.; Ferreira, I.C.F.R.; Martins, A.; Vasconcelos, M.H.. "Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential". Food Chemistry 132 1 (2012): 482-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-84355166472&partnerID=MN8TOARS.
    10.1016/j.foodchem.2011.11.031
  25. Lima, R.T.; Busacca, S.; Almeida, G.M.; Gaudino, G.; Fennell, D.A.; Vasconcelos, M.H.. "MicroRNA regulation of core apoptosis pathways in cancer". European Journal of Cancer 47 2 (2011): 163-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650686123&partnerID=MN8TOARS.
    10.1016/j.ejca.2010.11.005
  26. Queiroz, M.-J.R.P.; Calhelha, R.C.; Vale-Silva, L.A.; Pinto, E.; Almeida, G.M.; Vasconcelos, M.H.. "Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis". European Journal of Medicinal Chemistry 46 1 (2011): 236-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650510707&partnerID=MN8TOARS.
    10.1016/j.ejmech.2010.11.009
  27. Seca, H.; Almeida, G.M.; Guimarães, J.E.; Vasconcelos, M.H.. "miR signatures and the role of miRs in acute myeloid leukaemia". European Journal of Cancer 46 9 (2010): 1520-1527. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952583849&partnerID=MN8TOARS.
    10.1016/j.ejca.2010.03.031
  28. Palmeira, A.; Paiva, A.; Sousa, E.; Seca, H.; Almeida, G.M.; Lima, R.T.; Fernandes, M.X.; Pinto, M.; Vasconcelos, M.H.. "Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone". Chemical Biology and Drug Design 76 1 (2010): 43-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953008434&partnerID=MN8TOARS.
    10.1111/j.1747-0285.2010.00978.x
  29. Vaz, J.A.; Heleno, S.A.; Martins, A.; Almeida, G.M.; Vasconcelos, M.H.; Ferreira, I.C.F.R.. "Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines". Food and Chemical Toxicology 48 10 (2010): 2881-2884. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956392342&partnerID=MN8TOARS.
    10.1016/j.fct.2010.07.021
  30. Cazal, C.M.; Choosang, K.; Severino, V.G.P.; Soares, M.S.; Sarria, A.L.F.; Fernandes, J.B.; Silva, M.F.G.F.; et al. "Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines". Anti-Cancer Agents in Medicinal Chemistry 10 10 (2010): 769-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952740999&partnerID=MN8TOARS.
  31. Zainol, M.; Stoute, J.; Almeida, G.M.; Rapp, A.; Bowman, K.J.; Jones, G.D.D.. "Introducing a true internal standard for the Comet assay to minimize intra-and inter-experiment variability in measures of DNA damage and repair". Nucleic Acids Research 37 22 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-75649106826&partnerID=MN8TOARS.
    10.1093/nar/gkp826
  32. Grigg, J.; Tellabati, A.; Rhead, S.; Almeida, G.M.; Higgins, J.A.; Bowman, K.J.; Jones, G.D.; Howes, P.B.. "DNA damage of macrophages at an air-tissue interface induced by metal nanoparticles Macrophage". Nanotoxicology 3 4 (2009): 348-354. http://www.scopus.com/inward/record.url?eid=2-s2.0-71449090197&partnerID=MN8TOARS.
    10.3109/17435390903276917
  33. Song, R.; Duarte, T.L.; Almeida, G.M.; Farmer, P.B.; Cooke, M.S.; Zhang, W.; Sheng, G.; Fu, J.; Jones, G.D.D.. "Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells". Toxicology Letters 185 1 (2009): 23-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-58349122277&partnerID=MN8TOARS.
    10.1016/j.toxlet.2008.11.011
  34. Almeida, G.M.; Duarte, T.L.; Farmer, P.B.; Steward, W.P.; Jones, G.D.D.. "Multiple end-point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: Implications for predictive testing". International Journal of Cancer 122 8 (2008): 1810-1819. http://www.scopus.com/inward/record.url?eid=2-s2.0-40349089783&partnerID=MN8TOARS.
    10.1002/ijc.23188
  35. Duarte, Tiago L.; Almeida, Gabriela M.; Jones, George D.D.. "Investigation of the role of extracellular H2O2 and transition metal ions in the genotoxic action of ascorbic acid in cell culture models". Toxicology Letters 170 1 (2007): 57-65. http://dx.doi.org/10.1016/j.toxlet.2007.02.005.
    Publicado • 10.1016/j.toxlet.2007.02.005
  36. Moiseeva, E.P.; Almeida, G.M.; Jones, G.D.D.; Manson, M.M.. "Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells". Molecular Cancer Therapeutics 6 11 (2007): 3071-3079. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749087040&partnerID=MN8TOARS.
    10.1158/1535-7163.MCT-07-0117
  37. Barber, R.C.; Hickenbotham, P.; Hatch, T.; Kelly, D.; Topchiy, N.; Almeida, G.M.; Jones, G.D.D.; et al. "Radiation-induced transgenerational alterations in genome stability and DNA damage". Oncogene 25 56 (2006): 7336-7342. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749626120&partnerID=MN8TOARS.
    10.1038/sj.onc.1209723
  38. Almeida, G.M.; Duarte, T.L.; Steward, W.P.; Jones, G.D.D.. "Detection of oxaliplatin-induced DNA crosslinks in vitro and in cancer patients using the alkaline comet assay". DNA Repair 5 2 (2006): 219-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-30344435005&partnerID=MN8TOARS.
    10.1016/j.dnarep.2005.09.010
  39. Teixeira, J.P.; Gaspar, J.; Martinho, G.; Silva, S.; Rodrigues, S.; Mayan, O.; Martin, E.; Farmer, P.B.; Rueff, J.. "Aromatic DNA adduct levels in coke oven workers: Correlation with polymorphisms in genes GSTP1, GSTM1, GSTT1 and CYP1A1". Mutation Research - Genetic Toxicology and Environmental Mutagenesis 517 1-2 (2002): 147-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037182142&partnerID=MN8TOARS.
    10.1016/S1383-5718(02)00063-3
Tese / Dissertação
  1. Almeida, Gabriela M. "Analysis of DNA damage and cellular responses to platinum-based chemotherapeutic agents in "in vitro" models of non-small cell lung cancer". Doutoramento, University of Leicester, 2006.

Outros

Outra produção
  1. CD44v6 expression is a novel predictive marker of therapy response and poor prognosis in gastric cancer patients. 2018. Carla Pereira; Daniel Ferreira; Carolina Lemos; Diana Martins; Nuno Mendes; Daniela Almeida; Pedro Granja; et al. https://doi.org/10.1101/468934.
    10.1101/468934