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Victor Diogo Alves. Completed the Doutoramento in Veterinary Sciences, PhD in 2002 by Universidade de Lisboa Faculdade de Medicina Veterinária, Mestrado in PAPCC - MSc-like in 1993 by Universidade de Lisboa Faculdade de Medicina Veterinária and Licenciatura in Veterinary Medicine, DVM in 1984 by Universidade de Lisboa Faculdade de Medicina Veterinária. Is Auxiliary Professor (Tenure) in Universidade de Lisboa Faculdade de Medicina Veterinária. Published 23 articles in journals. Has 1 book(s).
Identificação

Identificação pessoal

Nome completo
Victor Diogo Alves

Nomes de citação

  • Alves, Victor Diogo

Identificadores de autor

Ciência ID
A11D-6F4D-30CA
ORCID iD
0000-0002-8430-4380

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador independente (B1)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2002
Concluído
 Veterinary Sciences, PhD (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
"African Swine Fever Virus Dna- Phenotype Dependent on Putative Subunit RNA polymerase Genes" (TESE/DISSERTAÇÃO)
 Unanimous approval
2002
Concluído
 Ciências Veterinárias (Doutoramento)
Especialização em Sem especialidade
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
"Fenótipo Dna do Vírus da Peste Suína Africana Dependente de Genes de Subunidades Putativas da Rna - Polimerase" (TESE/DISSERTAÇÃO)
1993
Concluído
 PAPCC - MSc-like (Mestrado)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
"Major Histocompatibility Complex - Swine Leucocyte Antigen Complex -SLA-" (TESE/DISSERTAÇÃO)
 Very Good
1984
Concluído
 Veterinary Medicine, DVM (Licenciatura)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
"Licenciatura em Medicina Veterinária" (TESE/DISSERTAÇÃO)
 15.48
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2016 - 2019 Professor Auxiliar (Docente Universitário) Universidade de Lisboa, Portugal
2013 - 2016 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
1993/03/01 - 2002/06/01 Assistente (Docente Universitário) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2018 - 2019 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Lisboa, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/06/01 - Atual Auxiliary Professor (Tenure) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2002/06/01 - 2007/07/01 Auxilliary Professor Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
1988/10/01 - 1993/03/01 Pre Assistant Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
1986/08/01 - 1988/09/30 Assistant Veterinarian Clínica Veterinária Infante Santo, Portugal
1985/03/01 - 1986/07/30 Military Veterinarian Escola Prática do Serviço Veterinário Militar, Portugal
1984/07/01 - 1985/05/01 Assistant Veterinarian Instituto Veterinário Dr. Marques de Almeida, Portugal
Projetos

Bolsa

Designação Financiadores
2021 - 2023 Glycomed - A new generation of enzymes for biofilm dispersion and immunomodulation in cancer
LISBOA-01-0247-FEDER-047033
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
 European Regional Development Fund
Concluído
2021 - 2023 ALGADIGEST – Desenvolvimento de uma nova solução de suplementação enzimática para a sustentabilidade da produção avícola com base na utilização eficiente de microalgas
LISBOA-01-0247-FEDER-070114
17/SI/2019/70114
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
 European Regional Development Fund
Concluído
2016/05 - 2019/05 An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition
PTDC/BBB-BEP/0869/2014
 Universidade de Coimbra
2016/05 - 2019/04 Molecular determinants of bacterial cellulosome diversity in different ecological niches
PTDC/BIA-MIC/5947/2014
 Universidade de Coimbra
2013/07 - 2016/06 Modern Structural Biology: Resources for the advancement of in-house X-ray Crystallography
125363
Provided by PTCRIS: 125363
 Fundação para a Ciência e a Tecnologia, I.P.
2013/06 - 2014/05 An Innovative Recombinant Hit-Maximization Strategy to Unravel the Structure of Cohesin-Dockerin Complexes of Bacteroides cellulosolvens and Acetivibrio cellulolyticus
129521
Provided by PTCRIS: 129521
 Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2013/06 The Cellulosome assembly: structure, function and specificity of new cellulases and supramolecular complexes
Provided by PTCRIS: 100359
100359
 Fundação para a Ciência e a Tecnologia, I.P.
2010/01 - 2013/06 Structure and function of novel Glycoside Hydrolases and Carbohydrate-Binding Modules of Clostridium thermocellum cellulosome
103980
Provided by PTCRIS: 103980
 Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2009/04 Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes
82210
Provided by PTCRIS: 82210
 Fundação para a Ciência e a Tecnologia, I.P.
2005/07 - 2007/12 Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes
59118
Provided by PTCRIS: 59118
 Fundação para a Ciência e a Tecnologia, I.P.
2001 - 2005 Perspectives on African Swine Fever (ASF) Control
QLK2-CT-2001-02216
 European Parliament Brussels
Produções

Publicações

Artigo em revista
  1. José M. Pestana; Cristina M. Alfaia; David Miguel Ribeiro; Mónica M. Costa; Daniela F.P. Carvalho; Cátia F. Martins; Victor M.D. Alves; et al. "Enhancing meat quality of weaned piglets with the dietary incorporation of Ulva lactuca and carbohydrases supplementation". Meat Science 205 (2023): 109306-109306. http://dx.doi.org/10.1016/j.meatsci.2023.109306.
    10.1016/j.meatsci.2023.109306
  2. Duarte, M.; Alves, V.D.; Correia, M.; Caseiro, C.; Ferreira, L.M.A.; Romão, M.J.; Carvalho, A.L.; et al. "Structure-function studies can improve binding affinity of cohesin-dockerin interactions for multi-protein assemblies". International Journal of Biological Macromolecules 224 (2023): 55-67. http://www.scopus.com/inward/record.url?eid=2-s2.0-85140335415&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2022.10.102
  3. Duarte, Marlene; Viegas, Aldino; Alves, Victor Diogo; Prates, José A.M.; Ferreira, Luís M.A.; Najmudin, Shabir; Cabrita, Eurico J.; et al. Autor correspondente: Bule, Pedro. "A dual cohesin–dockerin complex binding mode in Bacteroides cellulosolvens contributes to the size and complexity of its cellulosome". Journal of Biological Chemistry 296 (2021): 100552. http://dx.doi.org/10.1016/j.jbc.2021.100552.
    10.1016/j.jbc.2021.100552
  4. Bule P; Pires VM; Fontes CM; Alves VD. "Cellulosome assembly: paradigms are meant to be broken!". Current opinion in structural biology (2018): http://europepmc.org/abstract/med/29597100.
    10.1016/j.sbi.2018.03.012
  5. Bule P; Cameron K; Prates JAM; Ferreira LMA; Smith SP; Gilbert HJ; Bayer EA; et al. "Structure-function analyses generate novel specificities to assemble the components of multi-enzyme bacterial cellulosome complexes.". The Journal of biological chemistry (2018): http://europepmc.org/abstract/med/29367338.
    10.1074/jbc.ra117.001241
  6. Bule, Pedro; Pires, Virgínia M. R.; Alves, Victor D.; Carvalho, Ana Luísa; Prates, José A. M.; Ferreira, Luís M. A.; Smith, Steven P.; et al. "Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-25171-8.
    10.1038/s41598-018-25171-8,title
  7. Pires, V.M.R.; Pereira, P.M.M.; Brás, J.L.A.; Correia, M.; Cardoso, V.; Bule, P.; Alves, V.D.; et al. "Stability and ligand promiscuity of type A carbohydrate-binding modules are illustrated by the structure of Spirochaeta thermophila StCBM64C". Journal of Biological Chemistry 292 12 (2017): 4847-4860. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016255875&partnerID=MN8TOARS.
    10.1074/jbc.M116.767541
  8. Bule, P.; Alves, V.D.; Israeli-Ruimy, V.; Carvalho, A.L.; Ferreira, L.M.A.; Smith, S.P.; Gilbert, H.J.; et al. "Assembly of Ruminococcus flavefaciens cellulosome revealed by structures of two cohesin-dockerin complexes". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018985262&partnerID=MN8TOARS.
    10.1038/s41598-017-00919-w
  9. Israeli-Ruimy, V.; Bule, P.; Jindou, S.; Dassa, B.; Moraïs, S.; Borovok, I.; Barak, Y.; et al. "Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85012036956&partnerID=MN8TOARS.
    10.1038/srep42355
  10. Goyal, A.; Ahmed, S.; Sharma, K.; Gupta, V.; Bule, P.; Alves, V.D.; Fontes, C.M.G.A.; Najmudin, S.. "Molecular determinants of substrate specificity revealed by the structure of Clostridium thermocellum arabinofuranosidase 43A from glycosyl hydrolase family 43 subfamily 16". Acta Crystallographica Section D: Structural Biology 72 12 (2016): 1281-1289. http://www.scopus.com/inward/record.url?eid=2-s2.0-85005980967&partnerID=MN8TOARS.
    10.1107/S205979831601737X
  11. Freire, F.; Verma, A.; Bule, P.; Alves, V.D.; Fontes, C.M.G.A.; Goyal, A.; Najmudin, S.. "Conservation in the mechanism of glucuronoxylan hydrolysis revealed by the structure of glucuronoxylan xylanohydrolase (CtXyn30A) from Clostridium thermocellum". Acta Crystallographica Section D: Structural Biology 72 11 (2016): 1162-1173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995953684&partnerID=MN8TOARS.
    10.1107/S2059798316014376
  12. Bule, P.; Alves, V.D.; Leitão, A.; Ferreira, L.M.A.; Bayer, E.A.; Smith, S.P.; Gilbert, H.J.; Najmudin, S.; Fontes, C.M.G.A.. "Single binding mode integration of hemicellulose-degrading enzymes via adaptor scaffoldins in Ruminococcus flavefaciens cellulosome". Journal of Biological Chemistry 291 52 (2016): 26658-26669. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007035674&partnerID=MN8TOARS.
    10.1074/jbc.M116.761643
  13. Brás, Joana L. A.; Pinheiro, Benedita A.; Cameron, Kate; Cuskin, Fiona; Viegas, Aldino; Najmudin, Shabir; Bule, Pedro; et al. "Diverse specificity of cellulosome attachment to the bacterial cell surface". Scientific Reports 6 (2016): http://hdl.handle.net/10362/36982.
    https://doi.org/10.1038/srep38292
  14. Pires, A.J.; Ribeiro, T.; Thompson, A.; Venditto, I.; Fernandes, V.O.; Bule, P.; Santos, H.; et al. "Purification and crystallographic studies of a putative carbohydrate-binding module from the Ruminococcus flavefaciens FD-1 endoglucanase Cel5A". Acta Crystallographica Section:F Structural Biology Communications 71 (2015): 958-961. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938853150&partnerID=MN8TOARS.
    10.1107/S2053230X15009784
  15. Cameron, K.; Weinstein, J.Y.; Zhivin, O.; Bule, P.; Fleishman, S.J.; Alves, V.D.; Gilbert, H.J.; et al. "Combined crystal structure of a type I cohesin: Mutation and affinity binding studies reveal structural determinants of Cohesin-dockerin specificities". Journal of Biological Chemistry 290 26 (2015): 16215-16225. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941299732&partnerID=MN8TOARS.
    10.1074/jbc.M115.653303
  16. Cameron, K.; Najmudin, S.; Alves, V.D.; Bayer, E.A.; Smith, S.P.; Bule, P.; Waller, H.; et al. "Cell-surface attachment of bacterial multienzyme complexes involves highly dynamic protein-protein anchors". Journal of Biological Chemistry 290 21 (2015): 13578-13590. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929995654&partnerID=MN8TOARS.
    10.1074/jbc.M114.633339
  17. Bule, P.; Correia, A.; Cameron, K.; Alves, V.D.; Cardoso, V.; Fontes, C.M.G.A.; Najmudin, S.. "Overexpression, purification, crystallization and preliminary X-ray characterization of the fourth scaffoldin A cohesin from Acetivibrio cellulolyticus in complex with a dockerin from a family 5 glycoside hydrolase". Acta Crystallographica Section F:Structural Biology Communications 70 8 (2014): 1065-1067. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905507495&partnerID=MN8TOARS.
    10.1107/S2053230X14013181
  18. Fushinobu, S.; Alves, V.D.; Coutinho, P.M.. "Multiple rewards from a treasure trove of novel glycoside hydrolase and polysaccharide lyase structures: New folds, mechanistic details, and evolutionary relationships". Current Opinion in Structural Biology 23 5 (2013): 652-659. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885472999&partnerID=MN8TOARS.
    10.1016/j.sbi.2013.06.001
  19. Brás, J.L.A.; Alves, V.D.; Carvalho, A.L.; Najmudin, S.; Prates, J.A.M.; Ferreira, L.M.A.; Bolam, D.N.; et al. "Novel Clostridium thermocellum type I cohesin-dockerin complexes reveal a single binding mode". Journal of Biological Chemistry 287 53 (2012): 44394-44405. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871786607&partnerID=MN8TOARS.
    10.1074/jbc.M112.407700
  20. Cameron, K.; Alves, V.D.; Bule, P.; Ferreira, L.M.A.; Fontes, C.M.G.A.; Najmudin, S.. "Purification, crystallization and preliminary X-ray characterization of the Acetivibrio cellulolyticus type i cohesin ScaC in complex with the ScaB dockerin". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 68 9 (2012): 1030-1033. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865727287&partnerID=MN8TOARS.
    10.1107/S1744309112031922
  21. Luís, A.S.; Alves, V.D.; Romão, M.J.; Prates, J.A.M.; Fontes, C.M.G.A.; Najmudin, S.. "Overproduction, purification, crystallization and preliminary X-ray characterization of a novel carbohydrate-binding module of endoglucanase Cel5A from Eubacterium cellulosolvens". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 4 (2011): 491-493. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955111233&partnerID=MN8TOARS.
    10.1107/S1744309111004246
  22. Ribeiro, T.; Santos-Silva, T.; Alves, V.D.; Dias, F.M.V.; Luís, A.S.; Prates, J.A.M.; Ferreira, L.M.A.; Romão, M.J.; Fontes, C.M.G.A.. "Family 42 carbohydrate-binding modules display multiple arabinoxylan-binding interfaces presenting different ligand affinities". Biochimica et Biophysica Acta - Proteins and Proteomics 1804 10 (2010): 2054-2062. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956061008&partnerID=MN8TOARS.
    10.1016/j.bbapap.2010.07.006
  23. Correia, M.A.S.; Pires, V.M.R.; Gilbert, H.J.; Bolam, D.N.; Fernandes, V.O.; Alves, V.D.; Prates, J.A.M.; Ferreira, L.M.A.; Fontes, C.M.G.A.. "Family 6 carbohydrate-binding modules display multiple ß1,3-linked glucan-specific binding interfaces". FEMS Microbiology Letters 300 1 (2009): 48-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349667081&partnerID=MN8TOARS.
    10.1111/j.1574-6968.2009.01764.x
  24. Pinheiro, B.A.; Gilbert, H.J.; Sakka, K.; Fernandes, V.O.; Prates, J.A.M.; Alves, V.D.; Bolam, D.N.; Ferreira, L.M.A.; Fontes, C.M.G.A.. "Functional insights into the role of novel type I cohesin and dockerin domains from Clostridium thermocellum". Biochemical Journal 424 3 (2009): 375-384. http://www.scopus.com/inward/record.url?eid=2-s2.0-73149122122&partnerID=MN8TOARS.
    10.1042/BJ20091152
  25. Najmudin, S.; Guerreiro, C.I.P.D.; Carvalho, A.L.; Prates, J.A.M.; Correia, M.A.S.; Alves, V.D.; Ferreira, L.M.A.; et al. "Xyloglucan is recognized by carbohydrate-binding modules that interact with ß-glucan chains". Journal of Biological Chemistry 281 13 (2006): 8815-8828. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646840847&partnerID=MN8TOARS.
    10.1074/jbc.M510559200
Capítulo de livro
  1. Alves, V.D.; Fontes, C.M.G.A.; Bule, P.. "Cellulosomes: Highly Efficient Cellulolytic Complexes". 323-354. 2021.
    10.1007/978-3-030-58971-4_9
  2. Alves, Victor Diogo. "The Fine Structure of the Cellulosome Defines the Intricacies of Carbohydrate Deconstruction in the Mammalian Gut". 87-107. Springer International Publishing, 2020.
    10.1007/978-3-030-61981-7_5
  3. Alves, Victor Diogo. "Exogenous Enzymes Improve the Nutritive Value of Cereal-Based Diets for Monogastric Animals Through Different Mechanisms". 108-127. Springer International Publishing, 2020.
    10.1007/978-3-030-61981-7_6
Livro
  1. Brás, J.L.A.; Carvalho, A.L.; Viegas, A.; Najmudin, S.; Alves, V.D.; Prates, J.A.M.; Ferreira, L.M.A.; et al. Escherichia coli expression, purification, crystallization, and structure determination of bacterial cohesin-dockerin complexes. 2012.
    10.1016/B978-0-12-415931-0.00021-5