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During my research career, I have studied the cellular mechanisms of disease, focusing the heart and brain. I did my PhD and a first postdoctoral stay at the Hospital U. la Princesa, (Immunology department) with a BEFI fellowship (Ministerio de Sanidad y Consumo, 1999-2002) and I published 4 first author or first co-author publications in Blood, JBC, J. Immunology and Arthritis Rheum. Funded by an IF Marie Curie fellowship (2005-2007), I then moved to the National Institute for Medical Research (MRC, London) for 5.5 years, under the direction of Dr. Lovell-Badge, to study the regulation of neural stem cells by the endothelium (Gomez-Gaviro et al., J. Cardiovasc. Transl. Res. 2013; Gomez-Gaviro Meth. Mol. Biol. 2013; Gómez-Gaviro* et al., PNAS 2012). In 2010 I moved to Hospital Gregorio Marañón, funded by a second IF Marie Curie fellowship (2011-2013) (Cuadrado*, Gomez- Gaviro*, Biochem Pharmacol. 2014; *joint first author). During this three years I set up different surgical and molecular biology techniques in the field of cardiology and we studied the cardioprotective effects of the DT1 diterpene in the context of ischemia/reperfusion. In 2013 I joined the Medical Imaging Laboratory at the HGM and I opened a new line of research focused in Optics and Tissue Biology. I am now principal investigator Group Leader of this research line and I have published 9 articles as a senior author (Last or corresponding). I am currently investigating new technologies for 3D brain visualization. I have tutored more than 20 Master thesis and Degrees and currently I am the director of 2 doctoral thesis. I am a teacher in: Máster universitario de investigación en Medicina Traslacional (Universidad Complutense de Madrid (2017-)) and Máster in Física Médica. (UNED (2017-)). Principal Investigator in 3 Projects. More than 30 Publications in indexded journals with 9 publications as a senior and/or corresp. author. Total citations of more than 1230. Other Merits: - Management Committee (MC) COST-CA16124 since 2017- - Expert evaluator H2020-WIDESPREAD-05-2017-Twinning- - ANEP manager, Cardiovascular and Bioengineer área. FIS central panel, Mineco, 2017. - Evaluator of European projects Marie Curie: Call H2020-MSCA-IF-2015- LIF panel. 2015- - Vicechair of European projects Marie Curie: Call H2020-MSCA-IF-2016- LIF panel. 2016, 2017, 2018- - ANEP scientific projects evaluator: 2012- - Member of Animal Ethical Commitee in IISGM (2014- ) and European Projects in IISGM (2015-) - Member of the European Society of Cardiology (2011 - ) - Member of the Cell Biology Working Group of the European Society of Cardiology (2011 - ) - Referee of the journals Plos One, Stem cells, Histology & Histopathology, FEBS Letters, Journal of Cardiovascular Translational research,....
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Identificação

Identificação pessoal

Nome completo
Maria VIctoria Gómez-Gaviro

Nomes de citação

  • Gómez-Gaviro, Maria

Identificadores de autor

Ciência ID
AB1C-2F78-7B69
ORCID iD
0000-0002-8683-5150

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica
Formação
Grau Classificação
1999 - 2003
Concluído
 Surgery and experimental medicine (Doktor (PhD))
Hospital Universitario de la Princesa, Espanha
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2010/05/01 - Atual Investigador Coordenador (carreira) (Investigação) La Fundación para la Investigación Biomédica del Hospital Gregorio Marañón, Espanha
Instituto de Investigación Sanitaria Gregorio Marañón, Espanha
(...)
2005 - 2010 Assistente de Investigação (carreira) (Investigação) National Institute for Medical Research (MRC), Reino Unido

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2008/06/01 - 2008/06/30 Visiting Scientist King's College London, Reino Unido
2005/01/15 - 2005/01/31 Visiting Scientist Baylor College of Medicine, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2014 - 2018 Grant of National Agency of Chile. ¿Shh/Gli signaling in the Netrin/Neo1 axis¿. Fondecyt.
Fondecyt.
 N/A
2010 - 2011 Beca Recava: Servicio de Cardiología, HGGM, Spain.
Beca Recava
Bolseiro de Pós-Doutoramento
1999 - 2003 PhD Fellowship BEFI, Ministerio de Sanidad. Hospital de la Princesa, Madrid
PhD Fellowship BEFI
Bolseiro de Doutoramento

Projeto

Designação Financiadores
2019 - 2022 “Study and characterization of Fetomaternal Microchimerisms in a mouse model”.
FIS 18/00462. ISCIII.
Investigador responsável
2017 - 2021 European Action COST CA16124-Biobrillouin
CA16124-Biobrillouin
Investigador responsável
2015 - 2020 IP FIS 2018PI18-00462: Estudio de los microquimerismos fetomaternales en el infarto de miocardio. IISGM.
IP FIS 2018PI18-00462
Investigador
2013 - 2016 Human Frontiers Scientific program. “An innovative, interdisplicinary model system for studying the developmental origins of sleep and brain rhythms”. UC3M, Madrid
UC3M
Investigador responsável
Desativado
2011 - 2013 Marie Curie post-doctoral contract, EU. 7th FP, EU.
Grant ref. 275885
Bolseiro de Pós-Doutoramento
2005 - 2010 Quantum Grant, NIH, USA. Title: "A neurovascular niche". National Grants
Quantum Grant, NIH
Investigador
2006 - 2008 Marie Curie post-doctoral contract, EU, 6th FP, EU.
Grant ref. 024714
Produções

Publicações

Artigo em conferência
  1. Zufiria, B.; Bocancea, D. I.; Gómez-Gaviro, M. V.; Vaquero, J. J.; Desco, M.; Fresno, M.; Ripoll, J.; Arranz, A.. "3D imaging of the cleared intact murine colon with light sheet microscopy". 2016.
    10.1117/12.2212039
Artigo em revista
  1. Ortega, Felipe; Gomez-Villafuertes, Rosa; Benito-León, María; Martínez de la Torre, Margaret; Olivos-Oré, Luis A.; Arribas-Blazquez, Marina; Gomez-Gaviro, María Victoria; et al. "Salient brain entities labelled in P2rx7-EGFP reporter mouse embryos include the septum, roof plate glial specializations and circumventricular ependymal organs". Brain Structure and Function (2021): http://dx.doi.org/10.1007/s00429-020-02204-5.
    10.1007/s00429-020-02204-5
  2. Gómez-Gaviro, Maria Victoria; Sanderson, Daniel; Ripoll, Jorge; Desco, Manuel. "Biomedical Applications of Tissue Clearing and Three-Dimensional Imaging in Health and Disease". iScience 23 8 (2020): 101432. http://dx.doi.org/10.1016/j.isci.2020.101432.
    10.1016/j.isci.2020.101432
  3. Padrón-Barthe, Laura; Villalba-Orero, María; Gómez-Salinero, Jesús M.; Domínguez, Fernando; Román, Marta; Larrasa-Alonso, Javier; Ortiz-Sánchez, Paula; et al. "Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3ß". Circulation 140 14 (2019): 1188-1204. http://dx.doi.org/10.1161/circulationaha.119.040366.
    10.1161/circulationaha.119.040366
  4. Rafael J. Jiménez Riobóo; Manuel Desco; María Victoria Gómez-Gaviro. "Impact of optical tissue clearing on the Brillouin signal from biological tissue samples". Biomedical Optics Express (2019): https://doi.org/10.1364/BOE.10.002674.
    10.1364/BOE.10.002674
  5. Elísabet Bello-Arroyo; Hélio Roque; Alberto Marcos; Javier Orihuel; Alejandro Higuera-Matas; Manuel Desco; Valeria R. Caiolfa; et al. "MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice". Frontiers in Behavioral Neuroscience 12 (2018): https://doi.org/10.3389%2Ffnbeh.2018.00201.
    10.3389/fnbeh.2018.00201
  6. María-Victoria Gómez-Gaviro; Manuel Desco. "The Paracrine Neural Stem Cell Niche: New Actors in the Play". Current Stem Cell Reports 4 1 (2018): 33-38. https://doi.org/10.1007%2Fs40778-018-0112-1.
    10.1007/s40778-018-0112-1
  7. María Victoria Gómez-Gaviro; Evan Balaban; Diana Bocancea; María Teresa Lorrio; Maria Pompeiano; Manuel Desco; Jorge Ripoll; Juan José Vaquero. "Optimized CUBIC protocol for three-dimensional imaging of chicken embryos at single-cell resolution". Development 144 11 (2017): 2092-2097. https://doi.org/10.1242/dev.145805.
    10.1242/dev.145805
  8. Nehrhoff I; Ripoll J; Samaniego R; Desco M; Gómez-Gaviro MV. "Looking inside the heart: a see-through view of the vascular tree.". (2017): http://europepmc.org/abstract/med/28663930.
    10.1364/boe.8.003110
  9. Cioffi M; Trabulo SM; Vallespinos M; Raj D; Kheir TB; Lin ML; Begum J; et al. "The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.". (2017): http://europepmc.org/abstract/med/28423491.
    10.18632/oncotarget.15450
  10. Lara-Pezzi E; Desco M; Gatto A; Gómez-Gaviro MV. "Neurogenesis: Regulation by Alternative Splicing and Related Posttranscriptional Processes.". (2016): http://europepmc.org/abstract/med/27837180.
  11. Nehrhoff I; Bocancea D; Vaquero J; Vaquero JJ; Ripoll J; Desco M; Gómez-Gaviro MV. "3D imaging in CUBIC-cleared mouse heart tissue: going deeper.". (2016): http://europepmc.org/abstract/med/27699132.
    10.1364/boe.7.003716
  12. Cuadrado-Berrocal I; Gómez-Gaviro MV; Benito Y; Barrio A; Bermejo J; Fernández-Santos ME; Sánchez PL; et al. "A labdane diterpene exerts ex vivo and in vivo cardioprotection against post-ischemic injury: involvement of AKT-dependent mechanisms.". (2015): http://europepmc.org/abstract/med/25557296.
    10.1016/j.bcp.2014.12.011
  13. Gómez Gaviro MV; Sánchez Fernández PL; Lovell Badge R; Fernández Avilés F. "Looking for the niche: substance delivery into the lateral ventricle of the brain: the osmotic minipump system.". (2013): http://europepmc.org/abstract/med/23959987.
    10.1007/978-1-62703-508-8_11
  14. Gómez-Gaviro MV; Lovell-Badge R; Fernández-Avilés F; Lara-Pezzi E. "The vascular stem cell niche.". (2012): http://europepmc.org/abstract/med/22644724.
    10.1007/s12265-012-9371-x
  15. Gómez-Gaviro MV; Scott CE; Sesay AK; Matheu A; Booth S; Galichet C; Lovell-Badge R. "Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis.". (2012): http://europepmc.org/abstract/med/22232668.
    10.1073/pnas.1016199109
  16. Scott CE; Wynn SL; Sesay A; Cruz C; Cheung M; Gomez Gaviro MV; Booth S; et al. "SOX9 induces and maintains neural stem cells.". (2010): http://europepmc.org/abstract/med/20871603.
    10.1038/nn.2646
  17. Gómez-Gaviro, Maria. "Betacellulin Promotes Cell Proliferation in the Neural Stem Cell Niche". Human Gene Therapy 20 9 (2009): 1048-1093. http://dx.doi.org/10.1089/hum.2009.1722.
    10.1089/hum.2009.1722
  18. Gómez-Gaviro, Maria; Domínguez-Luis, Maria; Canchado, Javier; Calafat, Jero; Janssen, Hans; Lara-Pezzi, Enrique; Fourie, Anne; et al. "Expression and Regulation of the Metalloproteinase ADAM-8 during Human Neutrophil Pathophysiological Activation and Its Catalytic Activity on L-Selectin Shedding". The Journal of Immunology 178 12 (2007): 8053-8063. http://dx.doi.org/10.4049/jimmunol.178.12.8053.
    10.4049/jimmunol.178.12.8053
  19. Gómez-Gaviro M; Domínguez-Luis M; Canchado J; Calafat J; Janssen H; Lara-Pezzi E; Fourie A; et al. "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding.". (2007): http://europepmc.org/abstract/med/17548643.
    10.4049/jimmunol.178.12.8053
  20. García-Vicuña R; Gómez-Gaviro MV; Domínguez-Luis MJ; Pec MK; González-Alvaro I; Alvaro-Gracia JM; Díaz-González F. "CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients.". (2004): http://europepmc.org/abstract/med/15593223.
    10.1002/art.20615
  21. Lara-Pezzi E; Gómez-Gaviro MV; Gálvez BG; Mira E; Iñiguez MA; Fresno M; Martínez-A C; et al. "The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression.". Journal of Clinical Investigation 110 12 (2002): 1831-1838. http://europepmc.org/abstract/med/12488433.
    10.1172/jci200215887
  22. Gómez-Gaviro MV; González-Alvaro I; Domínguez-Jiménez C; Peschon J; Black RA; Sánchez-Madrid F; Díaz-González F. "Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs.". (2002): http://europepmc.org/abstract/med/12147693.
    10.1074/jbc.m205142200
  23. Go´mez-Gaviro, Maria Victoria; Domi´nguez-Jime´nez, Carmen; Carretero, Jorge Moreno; Sabando, Pedro; Gonza´lez-Alvaro, Isidoro; Sa´nchez-Madrid, Francisco; Di´az-Gonza´lez, Federico. "Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration". Blood 96 10 (2000): 3592-3600. http://dx.doi.org/10.1182/blood.v96.10.3592.
    10.1182/blood.v96.10.3592
  24. Gómez-Gaviro MV; Domínguez-Jiménez C; Carretero JM; Sabando P; González-Alvaro I; Sánchez-Madrid F; Díaz-González F. "Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration.". (2000): http://europepmc.org/abstract/med/11071659.
Edição de número de revista
  1. Gómez-Gaviro, Maria. "Ageing decreases the pool of newborn hepatocyte lineages, but does not impair their intrinsic proliferative response to partial hepatectomy in mice.". 73 (2020): 10.1016/S0168-8278(20)30748-0.
    10.1016/S0168-8278(20)30748-0
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021 I have attended more than 20 international meetings in which I have been invited to present my work.

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019 - Atual “Study and characterization of Feto-maternal Microchimerisms in a mouse model”. Ongoing. Started Dec. 2019.
Orientador
2017 - 2021 Study of Calcineurin beta1 expression in brain: function and role in pathology.
Orientador
2010 - 2020 7 Master theses (1 of them international), 17 Final degree projects.
Orientador

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2010 - Atual Journal Reviewer: Plos One, Hist, Cell and biology, and others.

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2019 - Atual Expert Reviewer (2019 - ), EU H2020 Widespread-Era-Chair
Avaliador
2018 - Atual Expert Reviewer (2018- ), EU H2020 Initial Training Network grants.
Avaliador
2017 - Atual Expert Reviewer (2017 - ), EU H2020 Widespread-Twinning
Avaliador
2016 - Atual Vice-chair and Expert Reviewer (2015), EU H2020 Marie Curie Individual Fellowships.
Avaliador
2012 - Atual National Grants - Adjunta Temporal, FIS Area de Cardiología, 2017, 2018. - ANEP Expert, Ramon y Cajal call, Central Panel, Ministerio de Economía y Comp., 2016, 2017. - ANEP Expert, Juan de la Cierva call, Central Panel, Ministerio de Economía y Comp., 2018. - ANEP Reviewer, Project Grants, 2012-.
Avaliador

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019 - Atual Organiser, Director and teacher of Surgical modules for rodents, IISGM
2017 - Atual Máster universitario de investigación en Medicina Traslacional. Universidad Complutense de Madrid.
2017 - Atual Máster in Física Médica. UNED: Módulo prácticas.
2010 - Atual Organiser, Director and Teacher (2010 - ), Course of Advance Microsurgery in rodents, IISGM.

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2017 - Atual European Action COST CA16124-Biobrillouin
Membro
2016 - Atual Member of CEEA, Animal Ethical committee, Instituto de Investigación Salud G. Marañón.
Membro

Processo legal

Descrição da atividade Caso
2005 - Atual Animal manipulation certification B, C and D. UCM, Madrid. Surgical and animal modules 1, 2, 3, and 4. Royal Veterinary school, London UK.