Carolina Tafalla (AC17-8EEF-06C0)

Curriculum Vitae

Carolina Tafalla

Carolina Tafalla is a permanent researcher of the National Institute of Animal Health (INIA) from Spain. She obtained her PhD degree in 2000 by the University of Santiago de Compostela with a thesis entitled "Interaction of the VHSV virus with the inespecific immune sistem of the turbot (Scophthalmus maximus)". After that, she was working in several institutions as postdoc researcher such as Investigation Marine Institute in Vigo (Spain) and Centre de Recherche Jouy-en-Josas (INRA, France). Her research line is focused in mechanisms of regulation of the immune system in fish; characterization of subpopulations of Lymphocites B in fishes; developmento of molecular markers to identification of leucocyte subpopulations; cytokine functionality in fishes; vaccine design; optimization of vaccines and search for new adjuvants for their use in aquaculture. During her career was awarded with two ERC grants, one ERC Starting Grant within the project "Teleost B lymphocytes, the equivalent of mammalian B1 lymphocytes?" and another ERC Consolidator Grant within the project "Teleost mucosal B1-like lymphocytes at the crossroad of tolerance and immunity". She was also in charge of several national and European projects, as well as, in contract with companies. Carolina Tafalla was published more than 100 scientific articles in SCI journals as well as several book chapters. She was supervisor of 6 PhD students and she created 4 patents. Also, she participated as scientific expert in several evaluation process of national projects in Spain and she was invited in several scientific meetings as plenary speaker. Finally, she is editor of several scientific journals such as: Fish and Shellfish Imunology, Development and Comparative Immunology and Frontiers in Immunology.

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Identificação

Identificação pessoal

Nome completo: Carolina Tafalla

Nomes de citação

Tafalla, Carolina

Identificadores de autor

Ciência ID: AC17-8EEF-06C0
ORCID iD: 0000-0002-0860-2976

Domínios de atuação

Ciências Agrárias - Agricultura, Silvicultura e Pescas - Pescas

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Espanhol; Castelhano (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Francês	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)

Formação

	Grau	Classificação
2000/04/14 Concluído	Aquaculture and Immunology (Doutoramento) Instituto de Investigacións Mariñas, Espanha "Interacción del virus de la septicemia hemorrágica viral (VHSV) con el sistema inmune inespecífico del rodaballo (Scophthalmus maximus)" (TESE/DISSERTAÇÃO)	Cum Laude
1996/06 Concluído	Biology degree (Licenciatura) Universidad de Navarra, Espanha

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2007/09 - Atual	Investigador Contratado (Investigação)	Centro de Investigación en Sanidad Animal, Espanha

2003/11 - 2007/09	Investigador (Investigação)	Centro de Investigación en Sanidad Animal, Espanha

2002/10 - 2003/06	Pós-doutorado (Investigação)	Institut National de Recherche pour l'Agriculture l'Alimentation et l'Environnement Centre Île-de-France Jouy-en-Josas Antony, França

2002/02 - 2002/10	Pós-doutorado (Investigação)	Instituto de Investigacións Mariñas, Espanha

2000/10 - 2001/10	Pós-doutorado (Investigação)	Instituto de Investigacións Mariñas, Espanha

2000/09 - 2000/12	Investigador Auxiliar (carreira) (Investigação)	Institut National de Recherche pour l'Agriculture l'Alimentation et l'Environnement Centre Île-de-France Jouy-en-Josas Antony, França

2000/01 - 2000/02	Investigador visitante (Investigação)	Virginia Institute of Marine Science William J Hargis Jr Library, Estados Unidos

1997/01 - 2000/01	Investigador (Investigação)	Instituto de Investigacións Mariñas, Espanha

1999/02 - 1999/05	Investigador visitante (Investigação)	Institut National de Recherche pour l'Agriculture l'Alimentation et l'Environnement Centre Île-de-France Jouy-en-Josas Antony, França
	Instituto de Investigacións Mariñas, Espanha
1996/01 - 1996/12	Estagiário de Investigação (Investigação)	Instituto de Investigacións Mariñas, Espanha

Projetos

Projeto

	Designação	Financiadores
2017/04/01 - 2022	Teleost mucosal B1-like lymphocytes at the crossroad of tolerance and immunity info:eu-repo/grantAgreement/EC/H2020/725061/EU Centro de Investigación en Sanidad Animal, Espanha	European Commission ERC Consolidator Grant Em curso
2017 - 2022	VetBioNet INFRAIA-01-2016-2017 VetBioNet INFRAIA-01-2016-2017 Investigador Centro de Investigación en Sanidad Animal, Espanha	H2020 Food Security Sustainable Agriculture and Forestry Marine Maritime and Inland Water Research and the Bioeconomy Em curso
2018 - 2020	Búsqueda de adyuvantes efectivos para vacunación oral de peces -- Investigador responsável Centro de Investigación en Sanidad Animal, Espanha	Gobierno de España Ministerio de Ciencia e Innovación Em curso
2015 - 2020	Advanced Tools and Research Strategies for Parasite Control in European farmed fish (ParaFishControl) -- Investigador responsável Centro de Investigación en Sanidad Animal, Espanha	H2020 Food Security Sustainable Agriculture and Forestry Marine Maritime and Inland Water Research and the Bioeconomy Em curso
2015 - 2020	Papel inmune de las dendríticas CD8+ de teleosteos en enfermedad y vacunación -- Investigador responsável Centro de Investigación en Sanidad Animal, Espanha	Gobierno de España Ministerio de Ciencia e Innovación Concluído
2011/12/01 - 2016	Teleost B lymphocytes, the equivalent of mammalian B1 lymphocytes? info:eu-repo/grantAgreement/EC/FP7/280469/EU Centro de Investigación en Sanidad Animal, Espanha	European Commission ERC Starting Grant Concluído
2011 - 2016	Targeted disease prophylaxis in European fish farming (Targetfish) -- Investigador responsável Centro de Investigación en Sanidad Animal, Espanha	European Commission Seventh Framework Programme for Research and Technological Development Concluído
2012 - 2014	Papel inmunomodulador y microbicida de las quimioquinas en trucha arco-iris. AGL2011-29676 Investigador responsável Centro de Investigación en Sanidad Animal, Espanha	Gobierno de España Ministerio de Ciencia e Innovación Concluído
2009 - 2012	The Network of Animal Disease Infectiology Research Facilities (NADIR) -- Investigador responsável Centro de Investigación en Sanidad Animal, Espanha	European Union
2009 - 2011	Nuevas estrategias de vacunación DNA frente a virus en peces utilizando el modelo trucha arcoiris / rhabdovirus de la septicemia hemorrágica vírica (VHSV): búsqueda de adyuvantes moleculares entre moléculas implicadas en la respuesta inmune temprana --- Investigador responsável Centro de Investigación en Sanidad Animal, Espanha Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Departamento de Reproducción Animal, Espanha Universidad Miguel Hernández de Elche, Espanha Universidad de León Departamento de Sanidad Animal, Espanha	Gobierno de España Ministerio de Ciencia e Innovación Concluído
2006 - 2007	Adjuvants and immunomodulators -- Investigador responsável Centro de Investigación en Sanidad Animal, Espanha	EPIZONE - European Network of Excellence Concluído
2005 - 2007	Mejora de las vacunas DNA frente a virus en acuicultura: análisis de la respuesta inmune protectiva no específica y específica en el modelo trucha /rabdovirus y modificación de las construcciones genéticas utilizadas hasta el momento. -- Investigador responsável Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Departamento de Reproducción Animal, Espanha Universidad Miguel Hernández de Elche, Espanha	Gobierno de España Ministerio de Ciencia e Innovación Concluído
2001 - 2003	Validación de técnicas de PCR para el diagnóstico de los parásitos Bonamia ostrae, Marteilia refringens y Perkinsus atlanticus en moluscos bivalvos de interés comercial para Galicia. -- Investigador Instituto de Investigacións Mariñas, Espanha Xunta de Galicia, Espanha Intecmar - Instituto Tecnológico del Mar, Espanha	Xunta de Galicia Concluído
2000 - 2003	Modulación de la respuesta inmune frente a enfermedades virales de peces. Bases moleculares. -- Investigador Instituto de Investigacións Mariñas, Espanha	Comisión Interministerial de Ciencia y Tecnología Concluído
2001 - 2002	Uso de los probióticos en acuicultura marina. Estudio de la influencia de distintos probióticos en el sistema inmune de rodaballo. -- Investigador Instituto de Investigacións Mariñas, Espanha	Fundación Novacaixagalicia
2000 - 2001	Identificación y caracterización del agente etiológico de la almeja en Galicia. -- Investigador Instituto de Investigacións Mariñas, Espanha	Xunta de Galicia Xunta de Galicia Consellería de Medio Rural e do Mar Concluído
1998 - 2001	Prevención de enfermedades virales en acuicultura marina. Patogenicidad, respuesta inmune y mecanismos de resistencia. None Investigador	Comisión Interministerial de Ciencia y Tecnología Concluído
1998 - 2001	Infectious fish from cDNA: A tool for salmonid protection in aquaculture --- Investigador Instituto de Investigacións Mariñas, Espanha	European Union Concluído
1998 - 1998	Actividad de la sintasa de óxido nítrico inducible en peces. Relación con enfermedades virales -- Investigador Instituto de Investigacións Mariñas, Espanha University of Aberdeen, Reino Unido	Gobierno de España Concluído

Produções

Publicações

Artigo em revista

Martín-Martín, Alba; Simón, Rocío; Abós, Beatriz; Díaz-Rosales, Patricia; Tafalla, Carolina. "Rainbow trout mount a robust specific immune response upon anal administration of thymus-independent antigens". Developmental & Comparative Immunology 109 (2020): 103715. http://dx.doi.org/10.1016/j.dci.2020.103715.
10.1016/j.dci.2020.103715
Velázquez, Janet; Pérez, Geysi; Semple, Shawna L.; Rodríguez-Ramos, Tania; Díaz-Rosales, Patricia; Ordás, María del Camino; Lugo, Juana María; et al. "First in vivo evidence of pituitary adenylate cyclase-activating polypeptide antiviral activity in teleost". Fish & Shellfish Immunology (2020): http://dx.doi.org/10.1016/j.fsi.2020.04.038.
10.1016/j.fsi.2020.04.038
Granja, Aitor G.; Perdiguero, Pedro; Martín-Martín, Alba; Díaz-Rosales, Patricia; Soleto, Irene; Tafalla, Carolina. "Rainbow Trout IgM+ B Cells Preferentially Respond to Thymus-Independent Antigens but Are Activated by CD40L". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.02902.
10.3389/fimmu.2019.02902
Perdiguero, Pedro; Martín-Martín, Alba; Benedicenti, Ottavia; Díaz-Rosales, Patricia; Morel, Esther; Muñoz-Atienza, Estefanía; García-Flores, Mónica; et al. "Teleost IgD+IgM- B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles". Cell Reports 29 13 (2019): 4223-4235.e5. http://dx.doi.org/10.1016/j.celrep.2019.11.101.
10.1016/j.celrep.2019.11.101
Leal, Esther; Ordás, María Camino; Soleto, Irene; Zarza, Carlos; McGurk, Charles; Tafalla, Carolina. "Functional nutrition modulates the early immune response against viral haemorrhagic septicaemia virus (VHSV) in rainbow trout". Fish & Shellfish Immunology 94 (2019): 769-779. http://dx.doi.org/10.1016/j.fsi.2019.09.070.
10.1016/j.fsi.2019.09.070
Soleto, Irene; Granja, Aitor G.; Simón, Rocío; Morel, Esther; Díaz-Rosales, Patricia; Tafalla, Carolina. "Identification of CD8a+ dendritic cells in rainbow trout (Oncorhynchus mykiss) intestine". Fish & Shellfish Immunology 89 (2019): 309-318. http://dx.doi.org/10.1016/j.fsi.2019.04.001.
10.1016/j.fsi.2019.04.001
Simón, Rocío; Díaz-Rosales, Patricia; Morel, Esther; Martín, Diana; Granja, Aitor G.; Tafalla, Carolina. "CpG Oligodeoxynucleotides Modulate Innate and Adaptive Functions of IgM+ B Cells in Rainbow Trout". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.00584.
10.3389/fimmu.2019.00584
Muñoz-Atienza, Estefanía; Aquilino, Carolina; Syahputra, Khairul; Al-Jubury, Azmi; Araújo, Carlos; Skov, Jakob; Kania, Per W.; et al. "CK11, a Teleost Chemokine with a Potent Antimicrobial Activity". The Journal of Immunology 202 3 (2019): 857-870. http://dx.doi.org/10.4049/jimmunol.1800568.
10.4049/jimmunol.1800568
Díaz-Rosales P; Muñoz-Atienza E; Tafalla C. "Role of teleost B cells in viral immunity.". Fish & shellfish immunology (2018): http://europepmc.org/abstract/med/30448446.
10.1016/j.fsi.2018.11.039
Muñoz-Atienza E; Távara C; Díaz-Rosales P; Llanco L; Serrano-Martínez E; Tafalla C. "Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum.". Fish & shellfish immunology (2018): http://europepmc.org/abstract/med/30439501.
10.1016/j.fsi.2018.11.027
Lugo JM; Tafalla C; Oliva A; Pons T; Oliva B; Aquilino C; Morales R; Estrada MP. "Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans.". Fish & shellfish immunology (2018): http://europepmc.org/abstract/med/30481557.
10.1016/j.fsi.2018.11.056
Lorenzen N; Tafalla C; Wiegertjes GF. "Preface to the special issue 'targeting fish vaccination'.". Fish & shellfish immunology (2018): http://europepmc.org/abstract/med/30243775.
10.1016/j.fsi.2018.09.048
Soleto I; Morel E; Martín D; Granja AG; Tafalla C. "Regulation of IgM+ B Cell Activities by Rainbow Trout APRIL Reveals Specific Effects of This Cytokine in Lower Vertebrates.". Frontiers in immunology (2018): http://europepmc.org/abstract/med/30150995.
10.3389/fimmu.2018.01880
Tafalla C; Granja AG. "Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish.". Frontiers in immunology (2018): http://europepmc.org/abstract/med/29930556.
10.3389/fimmu.2018.01285
Abós B; Bird S; Granja AG; Morel E; More Bayona JA; Barreda DR; Tafalla C. "Identification of the First Teleost CD5 Molecule: Additional Evidence on Phenotypical and Functional Similarities between Fish IgM+ B Cells and Mammalian B1 Cells.". Journal of immunology (Baltimore, Md. : 1950) (2018): http://europepmc.org/abstract/med/29866701.
10.4049/jimmunol.1701546
Abos B; Estensoro I; Perdiguero P; Faber M; Hu Y; Díaz Rosales P; Granja AG; et al. "Dysregulation of B Cell Activity During Proliferative Kidney Disease in Rainbow Trout.". Frontiers in immunology (2018): http://europepmc.org/abstract/med/29904385.
10.3389/fimmu.2018.01203
Soleto I; Fischer U; Tafalla C; Granja AG. "Identification of a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells in Teleost Respiratory Surfaces.". Frontiers in immunology (2018): http://europepmc.org/abstract/med/29422901.
10.3389/fimmu.2018.00059
Granja AG; Tafalla C. "Different IgM+ B cell subpopulations residing within the peritoneal cavity of vaccinated rainbow trout are differently regulated by BAFF.". Fish & shellfish immunology (2017): http://europepmc.org/abstract/med/28989090.
10.1016/j.fsi.2017.10.003
Leal E; Zarza C; Tafalla C. "Effect of vitamin C on innate immune responses of rainbow trout (Oncorhynchus mykiss) leukocytes.". Fish & shellfish immunology (2017): http://europepmc.org/abstract/med/28602736.
10.1016/j.fsi.2017.06.021
Soleto I; Abós B; Castro R; González L; Tafalla C; Granja AG. "The BAFF / APRIL axis plays an important role in virus-induced peritoneal responses in rainbow trout.". Fish & shellfish immunology (2017): http://europepmc.org/abstract/med/28302579.
10.1016/j.fsi.2017.03.023
Granja AG; Holland JW; Pignatelli J; Secombes CJ; Tafalla C. "Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease.". PloS one (2017): http://europepmc.org/abstract/med/28323891.
10.1371/journal.pone.0174249
Tafalla C; González L; Castro R; Granja AG. "B Cell-Activating Factor Regulates Different Aspects of B Cell Functionality and Is Produced by a Subset of Splenic B Cells in Teleost Fish.". Frontiers in immunology (2017): http://europepmc.org/abstract/med/28360916.
10.3389/fimmu.2017.00295
Castro R; Abós B; González L; Granja AG; Tafalla C. "Expansion and differentiation of IgM+ B cells in the rainbow trout peritoneal cavity in response to different antigens.". Developmental and comparative immunology (2017): http://europepmc.org/abstract/med/28088353.
10.1016/j.dci.2017.01.012
Rouxel RN; Tafalla C; Mérour E; Leal E; Biacchesi S; Brémont M. "Attenuated Infectious Hematopoietic Necrosis Virus with Rearranged Gene Order as Potential Vaccine.". Journal of virology (2016): http://europepmc.org/abstract/med/27681130.
10.1128/jvi.01024-16
Abós B; Wang T; Castro R; Granja AG; Leal E; Havixbeck J; Luque A; et al. "Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM(+) B Cells in The Absence of Germinal Centers.". Scientific reports (2016): http://europepmc.org/abstract/med/27481356.
10.1038/srep30004
Qi Z; Carolina Tafalla; Jason W. Holland; Qian Gao; Qihuan Zhang; Tiehui Wang; Xiuchun Wang. "Characterization and expression analysis of chemokine-like receptor 3 gene in rainbow trout Oncorhynchus mykiss". Fisheries science. (2016): http://europepmc.org/abstract/AGR/IND605372923.
10.1007/s12562-016-0997-5
Al-Jubury A; LaPatra S; Christensen ND; Zuo S; Tafalla C; Buchmann K. "Exclusion of IgD-, IgT- and IgM-positive immune cells in Ichthyophonus-induced granulomas in rainbow trout Oncorhynchus mykiss (Walbaum).". Journal of fish diseases (2016): http://europepmc.org/abstract/med/27136045.
10.1111/jfd.12475
Aquilino C; Granja AG; Castro R; Wang T; Abos B; Parra D; Secombes CJ; Tafalla C. "Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish.". Oncotarget (2016): http://europepmc.org/abstract/med/27003360.
10.18632/oncotarget.8163
Wang T; Johansson P; Abós B; Holt A; Tafalla C; Jiang Y; Wang A; et al. "First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities.". Oncotarget (2016): http://europepmc.org/abstract/med/26870894.
10.18632/oncotarget.7295
Tafalla C; Leal E; Yamaguchi T; Fischer U. "T cell immunity in the teleost digestive tract.". Developmental and comparative immunology (2016): http://europepmc.org/abstract/med/26905634.
10.1016/j.dci.2016.02.019
Al-Hussinee L; Pham PH; Russell S; Tubbs L; Tafalla C; Bols NC; Dixon B; Lumsden JS. "Temporary protection of rainbow trout gill epithelial cells from infection with viral haemorrhagic septicaemia virus IVb.". Journal of fish diseases (2016): http://europepmc.org/abstract/med/26850791.
10.1111/jfd.12442
Leal E; Granja AG; Zarza C; Tafalla C. "Distribution of T Cells in Rainbow Trout (Oncorhynchus mykiss) Skin and Responsiveness to Viral Infection.". PloS one (2016): http://europepmc.org/abstract/med/26808410.
10.1371/journal.pone.0147477
Bird S; Tafalla C. "Teleost Chemokines and Their Receptors.". Biology (2015): http://europepmc.org/abstract/med/26569324.
10.3390/biology4040756
Jensen LB; Wahli T; McGurk C; Eriksen TB; Obach A; Waagbø R; Handler A; Tafalla C. "Effect of temperature and diet on wound healing in Atlantic salmon (Salmo salar L.).". Fish physiology and biochemistry (2015): http://europepmc.org/abstract/med/26272065.
10.1007/s10695-015-0105-2
Granja AG; Leal E; Pignatelli J; Castro R; Abós B; Kato G; Fischer U; Tafalla C. "Identification of Teleost Skin CD8a+ Dendritic-like Cells, Representing a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells.". Journal of immunology (Baltimore, Md. : 1950) (2015): http://europepmc.org/abstract/med/26179908.
10.4049/jimmunol.1500322
Long M; Zhao J; Li T; Tafalla C; Zhang Q; Wang X; Gong X; Shen Z; Li A. "Transcriptomic and proteomic analyses of splenic immune mechanisms of rainbow trout (Oncorhynchus mykiss) infected by Aeromonas salmonicida subsp. salmonicida.". Journal of proteomics (2015): http://europepmc.org/abstract/med/25849251.
10.1016/j.jprot.2015.03.031
Castro R; Abós B; González L; Aquilino C; Pignatelli J; Tafalla C. "Molecular characterization of CD9 and CD63, two tetraspanin family members expressed in trout B lymphocytes.". Developmental and comparative immunology (2015): http://europepmc.org/abstract/med/25769915.
10.1016/j.dci.2015.03.002
Abós B; Castro R; González Granja A; Havixbeck JJ; Barreda DR; Tafalla C. "Early activation of teleost B cells in response to rhabdovirus infection.". Journal of virology (2014): http://europepmc.org/abstract/med/25410870.
10.1128/JVI.03080-14
Castro R; Abós B; Pignatelli J; von Gersdorff Jørgensen L; González Granja A; Buchmann K; Tafalla C. "Early immune responses in rainbow trout liver upon viral hemorrhagic septicemia virus (VHSV) infection.". PloS one (2014): http://europepmc.org/abstract/med/25338079.
10.1371/journal.pone.0111084
Pignatelli J; Castro R; González Granja A; Abós B; González L; Jensen LB; Tafalla C. "Immunological characterization of the teleost adipose tissue and its modulation in response to viral infection and fat-content in the diet.". PloS one (2014): http://europepmc.org/abstract/med/25333488.
10.1371/journal.pone.0110920
Luque A; González Granja A; González L; Tafalla C. "Establishment and characterization of a rainbow trout heart endothelial cell line with susceptibility to viral hemorrhagic septicemia virus (VHSV).". Fish & shellfish immunology (2014): http://europepmc.org/abstract/med/24698994.
10.1016/j.fsi.2014.03.027
Ballesteros NA; Rodríguez Saint-Jean S; Pérez-Prieto SI; Aquilino C; Tafalla C. "Modulation of genes related to the recruitment of immune cells in the digestive tract of trout experimentally infected with infectious pancreatic necrosis virus (IPNV) or orally vaccinated.". Developmental and comparative immunology (2013): http://europepmc.org/abstract/med/24370535.
10.1016/j.dci.2013.12.009
Castro R; Bromage E; Abós B; Pignatelli J; González Granja A; Luque A; Tafalla C. "CCR7 is mainly expressed in teleost gills, where it defines an IgD+IgM- B lymphocyte subset.". Journal of immunology (Baltimore, Md. : 1950) (2013): http://europepmc.org/abstract/med/24353268.
10.4049/jimmunol.1302471
Abós B; Castro R; Pignatelli J; Luque A; González L; Tafalla C. "Transcriptional heterogeneity of IgM+ cells in rainbow trout (Oncorhynchus mykiss) tissues.". PloS one (2013): http://europepmc.org/abstract/med/24324826.
10.1371/journal.pone.0082737
Castro R; Martínez-Alonso S; Fischer U; Haro NÁ; Soto-Lampe V; Wang T; Secombes CJ; et al. "DNA vaccination against a fish rhabdovirus promotes an early chemokine-related recruitment of B cells to the muscle.". Vaccine (2013): http://europepmc.org/abstract/med/24291197.
10.1016/j.vaccine.2013.11.062
Aquilino C; Castro R; Fischer U; Tafalla C. "Transcriptomic responses in rainbow trout gills upon infection with viral hemorrhagic septicemia virus (VHSV).". Developmental and comparative immunology (2013): http://europepmc.org/abstract/med/24269609.
10.1016/j.dci.2013.11.006
Ballesteros NA; Castro R; Abos B; Rodríguez Saint-Jean SS; Pérez-Prieto SI; Tafalla C. "The pyloric caeca area is a major site for IgM(+) and IgT(+) B cell recruitment in response to oral vaccination in rainbow trout.". PloS one (2013): http://europepmc.org/abstract/med/23785475.
10.1371/journal.pone.0066118
Tafalla C; Bøgwald J; Dalmo RA. "Adjuvants and immunostimulants in fish vaccines: current knowledge and future perspectives.". Fish & shellfish immunology (2013): http://europepmc.org/abstract/med/23507338.
10.1016/j.fsi.2013.02.029
Dixon B; Luque A; Abós B; Castro R; González-Torres L; Tafalla C. "Molecular characterization of three novel chemokine receptors in rainbow trout (Oncorhynchus mykiss).". Fish & shellfish immunology (2012): http://europepmc.org/abstract/med/23257202.
10.1016/j.fsi.2012.12.003
Pham PH; Lumsden JS; Tafalla C; Dixon B; Bols NC. "Differential effects of viral hemorrhagic septicaemia virus (VHSV) genotypes IVa and IVb on gill epithelial and spleen macrophage cell lines from rainbow trout (Oncorhynchus mykiss).". Fish & shellfish immunology (2012): http://europepmc.org/abstract/med/23257204.
10.1016/j.fsi.2012.12.004
Ordás MC; Castro R; Dixon B; Sunyer JO; Bjork S; Bartholomew J; Korytar T; et al. "Identification of a novel CCR7 gene in rainbow trout with differential expression in the context of mucosal or systemic infection.". Developmental and comparative immunology (2012): http://europepmc.org/abstract/med/22858409.
10.1016/j.dci.2012.07.001
Martinez-Alonso S; Vakharia VN; Saint-Jean SR; Pérez-Prieto S; Tafalla C. "Immune responses elicited in rainbow trout through the administration of infectious pancreatic necrosis virus-like particles.". Developmental and comparative immunology (2011): http://europepmc.org/abstract/med/21893091.
10.1016/j.dci.2011.07.010
Ordás MC; Cuesta A; Mercado L; Bols NC; Tafalla C. "Viral hemorrhagic septicaemia virus (VHSV) up-regulates the cytotoxic activity and the perforin/granzyme pathway in the rainbow trout RTS11 cell line.". Fish & shellfish immunology (2011): http://europepmc.org/abstract/med/21642001.
10.1016/j.fsi.2011.05.010
Alejo A; Tafalla C. "Chemokines in teleost fish species.". Developmental and comparative immunology (2011): http://europepmc.org/abstract/med/21414348.
10.1016/j.dci.2011.03.011
Montero J; Ordas MC; Alejo A; Gonzalez-Torres L; Sevilla N; Tafalla C. "CK12, a rainbow trout chemokine with lymphocyte chemo-attractant capacity associated to mucosal tissues.". Molecular immunology (2011): http://europepmc.org/abstract/med/21388685.
10.1016/j.molimm.2011.02.005
Montero J; Garcia J; Ordas MC; Casanova I; Gonzalez A; Villena A; Coll J; Tafalla C. "Specific regulation of the chemokine response to viral hemorrhagic septicemia virus at the entry site.". Journal of virology (2011): http://europepmc.org/abstract/med/21325404.
10.1128/jvi.02519-10
Martinez-Alonso S; Martinez-Lopez A; Estepa A; Cuesta A; Tafalla C. "The introduction of multi-copy CpG motifs into an antiviral DNA vaccine strongly up-regulates its immunogenicity in fish.". Vaccine (2010): http://europepmc.org/abstract/med/21134453.
10.1016/j.vaccine.2010.11.073
Lugo JM; Tafalla C; Leceta J; Gomariz RP; Estrada MP. "Differential expression pattern of pituitary adenylate cyclase-activating polypeptide (PACAP) alternative splicing variants and its receptors in the immune system of rainbow trout (Oncorhynchus mykiss).". Fish & shellfish immunology (2010): http://europepmc.org/abstract/med/21168508.
10.1016/j.fsi.2010.12.008
Chaves-Pozo, Elena; Cuesta, Alberto; Tafalla, Carolina. "Antiviral DNA vaccination in rainbow trout (Oncorhynchus mykiss) affects the immune response in the ovary and partially blocks its capacity to support viral replication in vitro". Fish & Shellfish Immunology 29 4 (2010): 579-586. http://dx.doi.org/10.1016/j.fsi.2010.06.006.
10.1016/j.fsi.2010.06.006
Chaves-Pozo, Elena; Montero, Jana; Cuesta, Alberto; Tafalla, Carolina. "Viral hemorrhagic septicemia and infectious pancreatic necrosis viruses replicate differently in rainbow trout gonad and induce different chemokine transcription profiles". Developmental & Comparative Immunology 34 6 (2010): 648-658. http://dx.doi.org/10.1016/j.dci.2010.01.009.
10.1016/j.dci.2010.01.009
Chaves-Pozo, Elena; Zou, Jun; Secombes, Chris J.; Cuesta, Alberto; Tafalla, Carolina. "The rainbow trout (Oncorhynchus mykiss) interferon response in the ovary". Molecular Immunology 47 9 (2010): 1757-1764. http://dx.doi.org/10.1016/j.molimm.2010.02.030.
10.1016/j.molimm.2010.02.030
Cuesta, A.; Chaves-Pozo, E.; de las Heras, A.I.; Saint-Jean, S. Rodríguez; Pérez-Prieto, S.; Tafalla, C.. "An active DNA vaccine against infectious pancreatic necrosis virus (IPNV) with a different mode of action than fish rhabdovirus DNA vaccines". Vaccine 28 19 (2010): 3291-3300. http://dx.doi.org/10.1016/j.vaccine.2010.02.106.
10.1016/j.vaccine.2010.02.106
Cuesta, A.; Dios, S.; Figueras, A.; Novoa, B.; Esteban, M.A.; Meseguer, J.; Tafalla, C.. "Identification of six novel CC chemokines in gilthead seabream (Sparus aurata) implicated in the antiviral immune response". Molecular Immunology 47 6 (2010): 1235-1243. http://dx.doi.org/10.1016/j.molimm.2009.12.014.
10.1016/j.molimm.2009.12.014
Montero, Jana; Chaves-Pozo, Elena; Cuesta, Alberto; Tafalla, Carolina. "Chemokine transcription in rainbow trout (Oncorhynchus mykiss) is differently modulated in response to viral hemorrhagic septicaemia virus (VHSV) or infectious pancreatic necrosis virus (IPNV)". Fish & Shellfish Immunology 27 6 (2009): 661-669. http://dx.doi.org/10.1016/j.fsi.2009.08.003.
10.1016/j.fsi.2009.08.003
Montero, Jana; Chaves-Pozo, Elena; Cuesta, Alberto; Tafalla, Carolina. "Immune effects observed after the injection of plasmids coding for rainbow trout (Oncorhynchus mykiss) CK5B, CK6 and CK7A chemokines demonstrate their immunomodulatory capacity and reveal CK6 as a major interferon inducer". Developmental & Comparative Immunology 33 10 (2009): 1137-1145. http://dx.doi.org/10.1016/j.dci.2009.06.008.
10.1016/j.dci.2009.06.008
Ruiz, S.; Schyth, B.D.; Encinas, P.; Tafalla, C.; Estepa, A.; Lorenzen, N.; Coll, J.M.. "New tools to study RNA interference to fish viruses: Fish cell lines permanently expressing siRNAs targeting the viral polymerase of viral hemorrhagic septicemia virus". Antiviral Research 82 3 (2009): 148-156. http://dx.doi.org/10.1016/j.antiviral.2009.02.200.
10.1016/j.antiviral.2009.02.200
Chico, V.; Ortega-Villaizan, M.; Falco, A.; Tafalla, C.; Perez, L.; Coll, J.M.; Estepa, A.. "The immunogenicity of viral haemorragic septicaemia rhabdovirus (VHSV) DNA vaccines can depend on plasmid regulatory sequences". Vaccine 27 13 (2009): 1938-1948. http://dx.doi.org/10.1016/j.vaccine.2009.01.103.
10.1016/j.vaccine.2009.01.103
Falco, A.; Encinas, P.; Carbajosa, S.; Cuesta, A.; Chaves-Pozo, E.; Tafalla, C.; Estepa, A.; Coll, J.M.. "Transfection improvements of fish cell lines by using deacylated polyethylenimine of selected molecular weights". Fish & Shellfish Immunology 26 3 (2009): 559-566. http://dx.doi.org/10.1016/j.fsi.2009.02.013.
10.1016/j.fsi.2009.02.013
Cuesta, A.; Tafalla, C.. "Transcription of immune genes upon challenge with viral hemorrhagic septicemia virus (VHSV) in DNA vaccinated rainbow trout (Oncorhynchus mykiss)". Vaccine 27 2 (2009): 280-289. http://dx.doi.org/10.1016/j.vaccine.2008.10.029.
10.1016/j.vaccine.2008.10.029
Ruiz, S.; Tafalla, C.; Cuesta, A.; Estepa, A.; Coll, J.M.. "In vitro search for alternative promoters to the human immediate early cytomegalovirus (IE-CMV) to express the G gene of viral haemorrhagic septicemia virus (VHSV) in fish epithelial cells". Vaccine 26 51 (2008): 6620-6629. http://dx.doi.org/10.1016/j.vaccine.2008.09.048.
10.1016/j.vaccine.2008.09.048
Esteban, Maria Ángeles; Meseguer, José; Tafalla, Carolina; Cuesta, Alberto. "NK-like and oxidative burst activities are the main early cellular innate immune responses activated after virus inoculation in reservoir fish". Fish & Shellfish Immunology 25 4 (2008): 433-438. http://dx.doi.org/10.1016/j.fsi.2008.07.001.
10.1016/j.fsi.2008.07.001
MONTERO, J; ESTEPA, A; COLL, J; TAFALLA, C. "Regulation of rainbow trout (Oncorhynchus mykiss) interleukin-8 receptor (IL-8R) gene transcription in response to viral hemorrhagic septicemia virus (VHSV), DNA vaccination and chemokines". Fish & Shellfish Immunology 25 3 (2008): 271-280. http://dx.doi.org/10.1016/j.fsi.2008.05.009.
10.1016/j.fsi.2008.05.009
Tafalla, Carolina; Sanchez, Esther; Lorenzen, Niels; DeWitte-Orr, Stephanie J.; Bols, Niels C.. "Effects of viral hemorrhagic septicemia virus (VHSV) on the rainbow trout (Oncorhynchus mykiss) monocyte cell line RTS-11". Molecular Immunology 45 5 (2008): 1439-1448. http://dx.doi.org/10.1016/j.molimm.2007.08.015.
10.1016/j.molimm.2007.08.015
Montero, Jana; Coll, Julio; Sevilla, Noemí; Cuesta, Alberto; Bols, Niels C.; Tafalla, Carolina. "Interleukin 8 and CK-6 chemokines specifically attract rainbow trout (Oncorhynchus mykiss) RTS11 monocyte–macrophage cells and have variable effects on their immune functions". Developmental & Comparative Immunology 32 11 (2008): 1374-1384. http://dx.doi.org/10.1016/j.dci.2008.05.004.
10.1016/j.dci.2008.05.004
Falco, A.; Brocal, I.; Pérez, L.; Coll, J.M.; Estepa, A.; Tafalla, C.. "In vivo modulation of the rainbow trout (Oncorhynchus mykiss) immune response by the human alpha defensin 1, HNP1". Fish & Shellfish Immunology 24 1 (2008): 102-112. http://dx.doi.org/10.1016/j.fsi.2007.09.007.
10.1016/j.fsi.2007.09.007
Falco, A.; Mas, V.; Tafalla, C.; Perez, L.; Coll, J.M.; Estepa, A.. "Dual antiviral activity of human alpha-defensin-1 against viral haemorrhagic septicaemia rhabdovirus (VHSV): Inactivation of virus particles and induction of a type I interferon-related response". Antiviral Research 76 2 (2007): 111-123. http://dx.doi.org/10.1016/j.antiviral.2007.06.006.
10.1016/j.antiviral.2007.06.006
Zou, Jun; Tafalla, Carolina; Truckle, Jonathan; Secombes, Chris J.. "Identification of a Second Group of Type I IFNs in Fish Sheds Light on IFN Evolution in Vertebrates". The Journal of Immunology 179 6 (2007): 3859-3871. http://dx.doi.org/10.4049/jimmunol.179.6.3859.
10.4049/jimmunol.179.6.3859
Tafalla, C.; Chico, V.; Pérez, L.; Coll, J.M.; Estepa, A.. "In vitro and in vivo differential expression of rainbow trout (Oncorhynchus mykiss) Mx isoforms in response to viral haemorrhagic septicaemia virus (VHSV) G gene, poly I:C and VHSV". Fish & Shellfish Immunology 23 1 (2007): 210-221. http://dx.doi.org/10.1016/j.fsi.2006.10.009.
10.1016/j.fsi.2006.10.009
Sanchez, E.; Coll, J.; Tafalla, C.. "Expression of inducible CC chemokines in rainbow trout (Oncorhynchus mykiss) in response to a viral haemorrhagic septicemia virus (VHSV) DNA vaccine and interleukin 8". Developmental & Comparative Immunology 31 9 (2007): 916-926. http://dx.doi.org/10.1016/j.dci.2006.12.008.
10.1016/j.dci.2006.12.008
Jimenez, N.; Coll, J.; Salguero, F.J.; Tafalla, C.. "Co-injection of interleukin 8 with the glycoprotein gene from viral haemorrhagic septicemia virus (VHSV) modulates the cytokine response in rainbow trout (Oncorhynchus mykiss)". Vaccine 24 27-28 (2006): 5615-5626. http://dx.doi.org/10.1016/j.vaccine.2006.04.061.
10.1016/j.vaccine.2006.04.061
Tafalla, C.; Estepa, A.; Coll, J.M.. "Fish transposons and their potential use in aquaculture". Journal of Biotechnology 123 4 (2006): 397-412. http://dx.doi.org/10.1016/j.jbiotec.2005.12.019.
10.1016/j.jbiotec.2005.12.019
Tafalla, C.; Coll, J.; Secombes, C.J.. "Expression of genes related to the early immune response in rainbow trout (Oncorhynchus mykiss) after viral haemorrhagic septicemia virus (VHSV) infection". Developmental & Comparative Immunology 29 7 (2005): 615-626. http://dx.doi.org/10.1016/j.dci.2004.12.001.
10.1016/j.dci.2004.12.001
Romero, A; Figueras, A; Tafalla, C; Thoulouze, MI; Bremont, M; Novoa, B. "Histological, serological and virulence studies on rainbow trout experimentally infected with recombinant infectious hematopoietic necrosis viruses". Diseases of Aquatic Organisms 68 (2005): 17-28. http://dx.doi.org/10.3354/dao068017.
10.3354/dao068017
Rocha, A.; Ruiz, S.; Tafalla, C.; Coll, J. M.. "Conformation- and Fusion-Defective Mutations in the Hypothetical Phospholipid-Binding and Fusion Peptides of Viral Hemorrhagic Septicemia Salmonid Rhabdovirus Protein G". Journal of Virology 78 17 (2004): 9115-9122. http://dx.doi.org/10.1128/jvi.78.17.9115-9122.2004.
10.1128/jvi.78.17.9115-9122.2004
Rocha, A; Ruiz, S; Tafalla, C; Coll, J.M. "Characterisation of the syncytia formed by VHS salmonid rhabdovirus G gene transfected cells". Veterinary Immunology and Immunopathology 99 3-4 (2004): 143-152. http://dx.doi.org/10.1016/j.vetimm.2004.01.006.
10.1016/j.vetimm.2004.01.006
Tafalla, C. "Cloning and analysis of expression of a gilthead sea bream (Sparus aurata) Mx cDNA". Fish & Shellfish Immunology 16 1 (2004): 11-24. http://dx.doi.org/10.1016/s1050-4648(03)00010-x.
10.1016/s1050-4648(03)00010-x
Tafalla, C.; Aranguren, R.; Secombes, C.J.; Castrillo, J.L.; Novoa, B.; Figueras, A.. "Molecular characterisation of sea bream (Sparus aurata) transforming growth factor ß1". Fish & Shellfish Immunology 14 5 (2003): 405-421. http://dx.doi.org/10.1006/fsim.2002.0444.
10.1006/fsim.2002.0444
Tafalla, C; Gómez-León, J; Novoa, B; Figueras, A. "Nitric oxide production by carpet shell clam (Ruditapes decussatus) hemocytes". Developmental & Comparative Immunology 27 3 (2003): 197-205. http://dx.doi.org/10.1016/s0145-305x(02)00098-8.
10.1016/s0145-305x(02)00098-8
Villamil, L.; Tafalla, C.; Figueras, A.; Novoa, B.. "Evaluation of Immunomodulatory Effects of Lactic Acid Bacteria in Turbot (Scophthalmus maximus)". Clinical and Vaccine Immunology 9 6 (2002): 1318-1323. http://dx.doi.org/10.1128/cdli.9.6.1318-1323.2002.
10.1128/cdli.9.6.1318-1323.2002
Tafalla, Carolina; Novoa, Beatriz; Figueras, Antonio. "Production of nitric oxide by mussel (Mytilus galloprovincialis) hemocytes and effect of exogenous nitric oxide on phagocytic functions". Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 132 2 (2002): 423-431. http://dx.doi.org/10.1016/s1096-4959(02)00050-7.
10.1016/s1096-4959(02)00050-7
Tafalla, Carolina; Figueras, Antonio; Novoa, Beatriz. "Possible role of LTB4 in the antiviral activity of turbot (Scophthalmus maximus) leukocyte-derived supernatants against viral hemorrhagic septicemia virus (VHSV)". Developmental & Comparative Immunology 26 3 (2002): 283-293. http://dx.doi.org/10.1016/s0145-305x(01)00076-3.
10.1016/s0145-305x(01)00076-3
Tafalla, C.; Novoa, B.. "Respiratory burst of turbot (Scophthalmus maximus) macrophages in response to experimental infection with viral haemorrhagic septicaemia virus (VHSV)". Fish & Shellfish Immunology 11 8 (2001): 727-734. http://dx.doi.org/10.1006/fsim.2001.0346.
10.1006/fsim.2001.0346
Tafalla, C; Figueras, A; Novoa, B. "Viral hemorrhagic septicemia virus alters turbot Scophthalmus maximus macrophage nitric oxide production". Diseases of Aquatic Organisms 47 (2001): 101-107. http://dx.doi.org/10.3354/dao047101.
10.3354/dao047101
Tafalla, Carolina; Novoa, Beatriz. "Requirements for nitric oxide production by turbot (Scophthalmus maximus) head kidney macrophages". Developmental & Comparative Immunology 24 6-7 (2000): 623-631. http://dx.doi.org/10.1016/s0145-305x(99)00087-7.
10.1016/s0145-305x(99)00087-7
Biacchesi, Stéphane; Yu, Yan-Xing; Béarzotti, Monique; Tafalla, Carolina; Fernandez-Alonso, Miriam; Brémont, Michel. "Rescue of synthetic salmonid rhabdovirus minigenomes". Journal of General Virology 81 8 (2000): 1941-1945. http://dx.doi.org/10.1099/0022-1317-81-8-1941.
10.1099/0022-1317-81-8-1941
Tafalla, C.; Figueras, A.; Novoa, B.. "Role of nitric oxide on the replication of viral haemorrhagic septicemia virus (VHSV), a fish rhabdovirus". Veterinary Immunology and Immunopathology 72 3-4 (1999): 249-256. http://dx.doi.org/10.1016/s0165-2427(99)00109-9.
10.1016/s0165-2427(99)00109-9
Tafalla, Carolina; Medina, Isabel; Figueras, Antonio; Novoa, Beatriz. "Production of leukotriene B4 and prostaglandin E2 by turbot (Scophthalmus maximus) leukocytes". Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 123 4 (1999): 351-356. http://dx.doi.org/10.1016/s0305-0491(99)00075-9.
10.1016/s0305-0491(99)00075-9
Tafalla, C; Figueras, A; Novoa, B. "In vitro interaction of viral haemorrhagic septicaemia virus and leukocytes from trout (Oncorhynchus mykiss) and turbot (Scophthalmus maximus)". Veterinary Immunology and Immunopathology 62 4 (1998): 359-366. http://dx.doi.org/10.1016/s0165-2427(97)00167-0.
10.1016/s0165-2427(97)00167-0

Capítulo de livro

Estepa, A.; Tafalla, C.; Coll, J.M.. "Viral Immune Defences in Fish". In Fish Defenses, 63-109. CRC Press, 2019.
10.1201/9780429187285-3
Zou, Jun; Castro, Rosario; Tafalla, Carolina. "Antiviral Immunity: Origin and Evolution in Vertebrates". In The Evolution of the Immune System, 173-204. Elsevier, 2016.
10.1016/b978-0-12-801975-7.00007-4
Dalmo, Roy; Bøgwald, Jarl; Tafalla, Carolina. "Adjuvants and Delivery Methods: Current and Novel". In Birkhäuser Advances in Infectious Diseases, 75-103. Springer Basel, 2016.
10.1007/978-3-0348-0980-1_4
Castro, Rosario; Tafalla, Carolina. "Overview of fish immunity". In Mucosal Health in Aquaculture, 3-54. Elsevier, 2015.
10.1016/b978-0-12-417186-2.00002-9
Tafalla, Carolina; Bøgwald, Jarl; Dalmo, Roy A.; Munang'andu, Hetron Mweemba; Evensen, Øystein. "Adjuvants in Fish Vaccines". In Fish Vaccination, 68-84. John Wiley & Sons, Ltd, 2014.
10.1002/9781118806913.ch7
Tafalla, Carolina; Alejo, A. "Chemokines in Teleost Fish Species". In Chemokines: Types, Functions, and Structural Characteristics., 73-88. Nova Science, 2010.
Tafalla, Carolina; Estepa, A.; Coll, J.. "New Vaccination Strategies for the Improvement of DNA Vaccines Against Virus in Fish.". In Vaccinations: Types, Potential Complications and Health Effects, 205-227. Nova Science, 2009.
Publicado
Tafalla, Carolina; Estepa, A.; Coll, J.. "New vaccination strategies for the improvement of DNA vaccines against viruses in fish.". In Aquaculture research trends., 213-235. New York, Estados Unidos: Nova Science Publishers, Inc. N.Y, 2008.
Publicado
Novoa, Beatriz; Tafalla, Carolina; Camino M. Ordás; Antonio Figueras. "Hemocitos de mejillón. Producción de radicales de oxígeno y nitrógeno". In Biología y cultivo del mejillón (Mytilus galloprovincialis) en Galicia: 113-121 (2007). Espanha: Consejo Superior de Investigaciones Científicas (España), 2007.
Publicado

Propriedade Intelectual

Patente

Estafania Muñoz Atienza; Tafalla, Carolina. 2019. "Métodos de bloqueo de las citoquinas de la familia TNF para tratamiento de enfermedades inflamatorias en peces". Espanha.
Pendente
Mockey, M; Dedieu, L; Tafalla, Carolina; Cuesta, Alberto. 2010. "Administración oral de DNA mediante el uso de liposomas cubiertos de alginato (Nouveaux liposomes de vaccination génique)". Espanha.
Permitida
Mario Pablo Estrada Garcia; Juana Maria Lugo González; Yamila Carpio Gonzalez; Tafalla, Carolina. 2010. "Use of PACAP for treating viral infections in aquatic organisms". Cuba.
Permitida
Tafalla, Carolina; Coll J. 2007. "Utilización de un vector codificando la interleuquina 8 de trucha como inmunoestimulante o adyuvante para vacunas en peces". Espanha.
Permitida

Atividades

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2019 - Atual	Regulación de los linfocitos B de peces durante procesos de infección y frente a distintas estrategias de vacunación Orientador de Alba Martín Martín
2018 - 2019	Caracterización de Blimp1 en trucha arcoiris Orientador de María Cristina Gómez Esparza	Degree in Biology (Licenciatura/Bacharelato) Universidad Rey Juan Carlos, Espanha
2018 - 2019	Efectos de la microbiota intestinal sobre los linfocitos B de peces Orientador	Degree in Biology (Licenciatura/Bacharelato) Universidad Rey Juan Carlos, Espanha
2015 - 2018/12	Papel inmune de las dendríticas CD8+ de teleosteos en enfermedad y vacunación. Orientador de Irene Soleto Fernández	Universidad Autónoma de Madrid, Espanha
2017 - 2018	Potencial adyuvante del toxoide LT (R192G/L211A) de Escherichia coli para la optimización de vacunas orales en trucha arcoíris (Oncorhynchus mykiss) Orientador de Lydia Tejedor Barbado	Degree in Biology (Licenciatura/Bacharelato) Universidad Rey Juan Carlos, Espanha
2014 - 2017/07	Regulación de la respuesta inmune de mucosas en peces Orientador	Universidad Complutense de Madrid, Espanha
2008 - 2012/06	Modulación de la respuesta inmune en trucha arcoíris (Oncorhynchus mykiss) frente a distintas estrategias vacunales antivirales. Orientador	Universidad Autónoma de Madrid, Espanha
2007 - 2011/07	Estudio del papel de las quimioquinas en la infección frente al virus de la septicemia hemorrágica viral (VHSV) y determinación de su posible uso como adyuvantes en vacunas DNA. Orientador	Universidad Complutense de Madrid, Espanha

Distinções

Prémio

2013	Young Virologist Sociedad Española de Virología, Espanha
2007	VII Premio JACUMAR de Investigación en Acuicultura 2007 Junta Nacional Asesora de Cultivos Marinos, Espanha
2000	Investigation award from Joung Researchers of the Academia Galega das Ciencias Fundación Novacaixagalicia, Espanha Xunta de Galicia, Espanha
1997	Best oral presentation in VIII International Conference on Disease of Fish and Shellfish International Conference on Disease of Fish and Shellfish, Reino Unido