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Miguel Xavier obtained his PhD from the University of Southampton (UoS) in 2018, as one of the 15 fellows recruited by the MSCA ITN LAPASO project (grant agreement no. 607350). The project brought together world-leading experts in microfluidics, lab-on-a-chip, and single cell sorting and analysis from top European academic and industrial institutions. This network created valuable collaborations that remain highly active today. Miguel's PhD was multidisciplinary and focused on the development of new microfluidic tools for label-free enrichment and characterisation of primary human bone marrow stem cells. The work resulted in the publication of 3 original research papers as first author, a review and, in 2017, MX was awarded the Gold Medal for Engineering as a Young Researcher at the STEM for Britain competition. He has also disseminated his research to the general public in science outreach events and in multiple international conferences where he has won awards for best poster and oral presentations. MX remains a Visiting Academic at the UoS under the invitation of Professor Richard Oreffo (H-index 92). In late 2018, MX was invited to join the INL to work on microfluidic applications to Life Sciences. At the INL, he founded the Microfluidics hub community and was appointed as one of the managers of the tissue culture and microfluidics labs. MX has continuously been involved in teaching, first as a demonstrator in practical classes at the UoS and as the supervisor of PhD, MSc and project students at INL. MX has also been able to secure his own funding through national, international and European funding agencies, including being awarded an MSCA Individual Fellowship in 2020 to execute the GASTRIC project (grant agreement no. 101003440). Thus far, Miguel has been involved in securing projects attracting nearly 2M€. His current h-index is 9 from 14 publications (9 as first author and two as last author) and one book chapter. Miguel's professional ambition is to become an independent researcher in the field of microfluidics applied to the life sciences, hoping to drive the development of innovative applications with a direct impact in people's quality of life.
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Identificação

Identificação pessoal

Nome completo
Jorge Miguel Queiros de Almeida Xavier

Nomes de citação

  • Xavier, Miguel

Identificadores de autor

Ciência ID
B01F-7F71-CC98
ORCID iD
0000-0002-0447-5439
Google Scholar ID
https://scholar.google.pt/citations?user=Q72DHa8AAAAJ&hl=en
Researcher Id
I-5862-2015
Scopus Author Id
57189376930

Endereços de correio eletrónico

  • miguel.xavier@inl.int (Profissional)

Moradas

  • Av Mestre José Veiga, 4715-330, Braga, Braga, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias
  • Ciências da Engenharia e Tecnologias - Engenharia Médica
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Exatas - Física
  • Ciências Naturais - Ciências Biológicas - Biofísica
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Espanhol; Castelhano Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Formação
Grau Classificação
2014/09/01 - 2018/05/29
Concluído
 Electronics and Electrical Engineering (Doctor of Philosophy)
University of Southampton, Reino Unido
"Label-free, microfluidic characterisation and sorting of human skeletal stem cells" (TESE/DISSERTAÇÃO)
2007/09 - 2012/10/08
Concluído
 Bioengenharia (Mestrado integrado)
Especialização em Engenharia Biomédica
Universidade do Porto Faculdade de Engenharia, Portugal
"Study and Development of a model for mimicking the gastric mucosa" (TESE/DISSERTAÇÃO)
 16/20
2004/09 - 2007/07
Concluído
 Ciências e Tecnologias (Ensino secundário)
Escola Secundária Martins Sarmento, Portugal
 188/200
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/10/16 - Atual Investigador Contratado (Investigação) International Iberian Nanotechnology Laboratory, Portugal
2018/08 - Atual Investigador visitante (Investigação) University of Southampton, Reino Unido
2014/09 - 2018/08 Investigador (Investigação) University of Southampton, Reino Unido
2013/01/01 - 2014/08/06 Assistente de Investigação (carreira) (Investigação) Instituto Nacional de Engenharia Biomédica, Portugal
2014/01 - 2014/02 Investigador visitante (Investigação) Universidade da Madeira Centro de Química da Madeira, Portugal
Instituto Nacional de Engenharia Biomédica, Portugal
Projetos

Bolsa

Designação Financiadores
2023/01 - 2027/12 3DSecret - 3D spheroids derived from single cells for discovering stochastic patterns behind metastasis
101099066
Co-Investigador Responsável (Co-IR)
European Commission
Em curso
2022/01 - 2024/12 JumpIN - HiJacking the peripheral neurons retrograde trafficking machinery to deliver neUroprotective Molecules to sPinal cord InterNeurons
PTDC-BTM-MAT4156.2021
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2020/10 - 2022/10 Gastrointestinal Tract on Chip - An automated microfluidics-based modular device for complete simulation of the processes of digestion and absorption of orally ingested bioactive compounds
101003440
 European Commission
2018/10/16 - 2021/04/30 Modular micro-device for human gastrointestinal tract simulation: MICRODIGEST
037716
Bolseiro de Investigação
International Iberian Nanotechnology Laboratory, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2013/01/01 - 2014/08 DENDRIMAT - New materials for drug/gene delivery based on the self-assembly of dendrimer-chitosan-single stranded DNA
info:eu-repo/grantAgreement/FCT/3599-PPCDT/112428/PT
Investigador
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2018/02 - 2018/08 Development of a Microfluidic Lab-On-a-Chip Device into a Working Prototype for Clinical Application in Bone Tissue Engineering
HEIF
Bolseiro de Pós-Doutoramento
University of Southampton, Reino Unido
 Higher Education Funding Council for England
Concluído
2017/10 - 2018/08 Identifying the skeletal stem cell for regeneration: harnessing smart nanoparticles and single cell DropSeq molecular profiling platforms
BB/P017711/1
Bolseiro de Pós-Doutoramento
University of Southampton Institute of Developmental Science, Reino Unido
 Biotechnology and Biological Sciences Research Council
Em curso
2014/09/01 - 2017/08/31 LAPASO - Microfluidics for label-free particle sorting
607350
Bolseiro de Doutoramento
University of Southampton, Reino Unido
 European Commission
Concluído
Produções

Publicações

Artigo em conferência
  1. Xavier, Miguel; Spencer, D.; Oreffo, R.O.C.; Morgan, H.. "Label-free Microfluidic sorting of primary human Skeletal stem cells for bone regeneration: A bio-physical characterisation". 2016.
Artigo em revista
  1. Spencer, Ana; Xavier, Miguel; Guimarães, Ana Sofia; adriana vilaça; Ariel Ionescu; Rafael Santos; Gomez-Lazaro, Maria; et al. "Unveiling the potential of neuron-targeted dendriplexes for siRNA with a PNS-CNS-on-chip model". Nano Today (2024):
    Submetido
  2. Spencer, Ana; Adriana Vilaça; Guimarães, Ana Sofia; Xavier, Miguel; Rafael Santos; Ariel Ionescu; Gomez-Lazaro, Maria; et al. "Advancing neurotherapeutics: chitosan nanoparticles as efficient vehicles for siRNA delivery". Small (2024):
    Submetido
  3. Maria Helena Macedo; Mafalda Dias Neto; Lorenzo Pastrana; Catarina Gonçalves; Xavier, Miguel. Autor correspondente: Xavier, Miguel. "Recent Advances in Cell-Based In Vitro Models to Recreate Human Intestinal Inflammation". Advanced Science (2023): http://dx.doi.org/10.1002/advs.202301391.
    10.1002/advs.202301391
  4. Xavier, Miguel; Patrícia M. Rodrigues; Mafalda Dias Neto; Maria I. Guedes; Victor Calero; Lorenzo Pastrana; Catarina Gonçalves. "From mouth to gut: microfluidic in vitro simulation of human gastro-intestinal digestion and intestinal permeability". The Analyst (2023): http://dx.doi.org/10.1039/d2an02088b.
    10.1039/d2an02088b
  5. Inês A. Parente; Xavier, Miguel; Dalila Roupar; Isabel R. Amado; Paulo Berni; Cláudia Botelho; José A. Teixeira; et al. "Effect of prebiotic fermentation products from primary human gut microbiota on an in vitro intestinal model". Journal of Functional Foods (2022): http://dx.doi.org/10.1016/j.jff.2022.105200.
    10.1016/j.jff.2022.105200
  6. Patrícia M. Rodrigues; Xavier, Miguel; Victor Calero; Lorenzo Pastrana; Catarina Gonçalves. "Partitioning of Small Hydrophobic Molecules into Polydimethylsiloxane in Microfluidic Analytical Devices". Micromachines (2022): https://www.mdpi.com/2072-666X/13/5/713.
    10.3390/mi13050713
  7. Xavier, Miguel; Parente, Inês A.; Rodrigues, Patrícia M.; Cerqueira, Miguel A.; Pastrana, Lorenzo; Gonçalves, Catarina. "Safety and fate of nanomaterials in food: The role of in vitro tests". Trends in Food Science & Technology 109 (2021): 593-607. http://dx.doi.org/10.1016/j.tifs.2021.01.050.
    10.1016/j.tifs.2021.01.050
  8. Xavier, Miguel; Kyriazi, Maria-Eleni; Lanham, Stuart; Alexaki, Konstantina; Matthews, Elloise; El-Sagheer, Afaf H.; Brown, Tom; Kanaras, Antonios G.; Oreffo, Richard O. C.. "Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids". ACS Nano (2021): https://publons.com/wos-op/publon/43672242/.
    10.1021/ACSNANO.0C10683
  9. Costa JR; Xavier, Miguel; Amado IR; Gonçalves C; Castro PM; Tonon RV; Cabral LMC; Pastrana L; Pintado ME. "Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities.". Materials science & engineering. C, Materials for biological applications (2020): http://europepmc.org/abstract/med/33321615.
    10.1016/j.msec.2020.111551
  10. Xavier, Miguel; García-Hevia, Lorena; Amado, Isabel R; Pastrana, Lorenzo; Gonçalves, Catarina. "<p>In Vitro Intestinal Uptake And Permeability Of Fluorescently-Labelled Hyaluronic Acid Nanogels</p>". International Journal of Nanomedicine Volume 14 (2019): 9077-9088. http://dx.doi.org/10.2147/ijn.s224255.
    10.2147/ijn.s224255
  11. Xavier, Miguel; Holm SH; Beech JP; Spencer D; Tegenfeldt JO; Oreffo ROC; Morgan H. "Label-free enrichment of primary human skeletal progenitor cells using deterministic lateral displacement.". Lab on a chip (2019): http://europepmc.org/abstract/med/30632599.
    10.1039/c8lc01154k
  12. Sofia D. Santos; Xavier, Miguel; Diana M. Leite; Débora A. Moreira; Beatriz Custódio; Marília Torrado; Rita Castro; et al. "PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia". Journal of Controlled Release (2018): https://doi.org/10.1016%2Fj.jconrel.2018.10.006.
    10.1016/j.jconrel.2018.10.006
  13. Xavier, Miguel; María C. de Andrés; Daniel Spencer; Richard O. C. Oreffo; Hywel Morgan. "Size and dielectric properties of skeletal stem cells change critically after enrichment and expansion from human bone marrow: consequences for microfluidic cell sorting". Journal of The Royal Society Interface 14 133 (2017): 20170233-20170233. https://doi.org/10.1098%2Frsif.2017.0233.
    10.1098/rsif.2017.0233
  14. Xavier, Miguel; Oreffo, R.O.C.; Morgan, H.. "Skeletal stem cell isolation: A review on the state-of-the-art microfluidic label-free sorting techniques". Biotechnology Advances 34 5 (2016): 908-923. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973900767&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2016.05.008
  15. Xavier, Miguel; Rosendahl, P.; Herbig, M.; Kräter, M.; Spencer, D.; Bornhäuser, M.; Oreffo, R.O.C.; et al. "Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry". Integrative Biology (United Kingdom) 8 5 (2016): 616-623. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969929926&partnerID=MN8TOARS.
    10.1039/c5ib00304k
Capítulo de livro
  1. Alexandra Teixeira; Adriana Carneiro; Paulina Piairo; Xavier, Miguel; Alar Ainla; Cláudia Lopes; Maria Sousa-Silva; et al. "Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine". 2022.
    10.1007/978-3-031-04039-9_22
Poster em conferência
  1. Spencer, Ana; Xavier, Miguel; Guimarães, Sofia Cunha; Leiro, Victoria; Pêgo, Ana Paula. "Exploring Microfluidics as a Neuro-platform Towards the Design of a Novel Targeted Dendritic Vectors". Trabalho apresentado em 32nd Annual Conference of the European Society for Biomaterials (ESB), 2022.
  2. Spencer, Ana; Xavier, Miguel; Guimarães, Sofia Cunha; Victoria Leiro; Pêgo, Ana. "Exploring Microfluidics as a Neuro-platform Towards the Design of a Novel Targeted Dendritic Vector". Trabalho apresentado em 32nd Annual Conference of the European Society for Biomaterials (ESB), 2022.
  3. Spencer, Ana; Xavier, Miguel; Guimaraes, S.C; Leiro, Victoria; Pêgo, Ana Paula. Autor correspondente: Pêgo, Ana Paula. "Microfluidics for the assessment of nanoparticle intracellular trafficking in neurons". Trabalho apresentado em FENS Forum 2022 | International Neuroscience Conference. Paris, France, 2022.
  4. Santos, SD; Xavier, Miguel; Leite DM; Moreira, Débora; Custódio, Beatriz; Torrado M; Castro, R.; et al. "The transport of therapeutic molecules to the ischemic brain: dendrimers as carriers in pre-clinical studies". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  5. Santos, SD; Xavier, Miguel; Leite, DM; Moreira, Débora; Custódio, Beatriz; Torrado M; Castro, R; et al. "Blood-Brain Barrier Transport and Neuronal Uptake of PAMAM Dendrimers after Focal Brain Ischemia". Trabalho apresentado em i3S annual meeting, 2018.
  6. Santos, SD; Xavier, Miguel; Leite DM; Moreira, Débora; Castro, R; Leiro, Victoria; Rodrigues, J.; Tomás, Helena; Pêgo, Ana. "Nanoparticle-mediated Blood-Brain Barrier Transport for Neuronal Delivery in Focal Brain Ischemia". Trabalho apresentado em 10th International Symposium on Neuroprotection and Neurorepair, 2018.

Outros

Outra produção
  1. Optimising DNA-Coated Gold Nanoparticles to Enrich Skeletal Stem Cells from Human Bone Marrow Samples. 2019. Xavier, Miguel. http://dx.doi.org/10.1101/2019.12.19.882563.
    10.1101/2019.12.19.882563
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/02/06 Dos and Don’ts of microfluidics and organ-on-a-chip devices XIX Jornadas de Engenharia Biomédica
(Portugal)
2022/06 Microfluidics for Complete Simulation of the Human Gastrointestinal Tract. EMBL Microfluidics 2022
(Heidelberg, Alemanha)
2021/11 Microfluidic Simulation of Human Gastrointestinal Digestion and Cell-based Intestinal Absorption. Nanobiotech Montreux Nanobiotech Montreux
(Montreux, Suiça)
2021/06/29 Microfluidics for Biomedical Engineering Applications: From Cell Sorting to Organ-On-Chip 4th Doctoral College in Engineering
(Portugal)
2019/02 Microfluidics, from cell sorting to organ-on-a-chip IV Jornadas de Bioengenharia UTAD
(Portugal)
2017/09 Size and deformation-based cell sorting using deterministic lateral displacement – prospects for skeletal stem cell isolation from bone marrow European workshop on label-free particle sorting
(Lund, Suécia)
2017/06 Microfluidic characterisation of size, dielectric and mechanical properties of primary skeletal stem cells from human bone marrow for label-free cell isolation Gordon Research Seminar – Physics and Chemistry of Microfluidics
(Lucca, Itália)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/02 - Atual Development of a bioengineered patient-specific microphysiological in vitro model of intestinal inflammation
Coorientador
2023/01 - 2024/02 Assessment of the viability of circulating tumor cells in microfluidics
Orientador
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências e Tecnologia, Portugal
2023/01 - 2024/01 Short-chain fatty acids as potential modulators of a new ruthenium-based anticancer drug in colorectal cancer therapy
Orientador
Universidade do Minho Escola de Ciências, Portugal
2019/07 - 2022/11 Modification of polydimethylsiloxane (PDMS) to reduce the absorption of small molecules in analytical microfluidic devices
Coorientador
 Biofísica e Bionanossistemas (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
2022/01 - 2022/09 Development of functional gut-on-chip epithelial models to study intestinal absorption
Orientador
Universidade do Porto Faculdade de Engenharia, Portugal
2021/05 - 2022/02 CELL-BASED MICRODEVICE AS A TOOL FOR PREDICTIVE INTESTINAL RESPONSES
Coorientador
 Engenharia Biomédica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/03 - 2022/02 Development of a sensorised and automated digestion-on-chip device
Orientador
2019/09 - 2021/01 Development of a new Colon-Host simulator
Coorientador
 Mestrado em Biotecnologia (Mestrado)
Universidade do Minho Escola de Engenharia, Portugal
2019/07 - 2020/02 Development of low-cost peripherals for the operation of microfluidic devices
Orientador de Ricardo Nuno Marquês Cardoso
 Bioengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/06 - Atual Chair of the GRS Physics and Chemistry of Microfluidics 2025 (2023/06)
Conferência (Membro da Comissão Organizadora)

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/02/26 Development of a microfluidic-based 3D bioprinting systems to create hierarchical in vitro models of human tissues
Arguente
 Federico Serpe (Doutoramento)
Università degli Studi di Roma La Sapienza, Itália
2023 Cancer models in Organ-on-a-Chip systems
Arguente principal
 JOÃO PEDRO SANTANA CERDEIRA (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 ESTABLISHMENT OF A 3D MULTI-LAYERED INTESTINAL INFLAMMATION MODEL
Arguente principal
 Bárbara Ferreira (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/06 Mimicking the bone in a 3D compartmentalized microfluidic chip to fight cancer associated bone pain
Arguente
 Andrea Bortolin (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2018/10 Development of bacteriophage-loaded microstructures using Microfluidics
Arguente principal
 Luís Filipe Alves Passos (Mestrado)
Universidade do Minho Escola de Engenharia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2021 - 2022 European Society of Biomaterials
2021 - 2021 Nanobiotech Montreux

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/01 - 2022/06 Micromachines (2072-666X) MDPI

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023 - 2034 Micro and nano technologies for cancer research (Curso de mestrado (conclusão do curso de especialização)) Universidade do Minho, Portugal
2014/11 - 2017/11 Lab tutorials on microfabrication and microcontact printing Bionanotechnology (Bachelor) University of Southampton Faculty of Physical Sciences and Engineering, Reino Unido

Tutoria

Tópico Nome do aluno
2019/04 - 2019/09 On-chip culture of human endothelial and cancer cells Elisa Hysaj
Distinções

Prémio

2021 Best Scientific Demo
European Researcher's Night organising committee, Portugal
2017 Gold Medal for Excellence in Engineering by a Young Research
The Houses of Parliament, Reino Unido
2017 Winner of the 3-Minute Thesis Faculty Competition
University of Southampton Faculty of Physical Sciences and Engineering, Reino Unido
2017 Best oral communication
European Workshop on Label-free Particle Sorting, Suécia
2017 Best oral communication
University of Southampton, Reino Unido
2013 Best Poster communication
Instituto Nacional de Engenharia Biomédica, Portugal
2007 Best Sciences Student Award
Associação dos Antigos Estudantes do Liceu de Guimarães, Portugal
2007 Best Mathematics Student Award
Associação dos Antigos Estudantes do Liceu de Guimarães, Portugal
2007 Merit and Excellence Award
Escola Secundária Martins Sarmento, Portugal