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I earned a Bachelor of Science degree in Biochemistry from the University of Beira Interior in Portugal in 2005. Subsequently, I received a 30-month pre-doctoral fellowship (POCI/SAU-NEU/55380/2004) in 2006, focusing on molecular and cell biology, with some of the research integrated into my 2008 Master's thesis in Biochemistry. In 2014, I defended my PhD in Neurosciences at the Netherlands Institute for Neurosciences (NIN) in Amsterdam. Afterward, I moved to Erasmus University Medical Centre (EMC) in Rotterdam, where I undertook a post-doctoral position in Dr. Erik Lubberts Lab, collaborating with Prof. Björn Claussen, gaining expertise in immunology. Returning to retinal research in 2016, I joined Leiden University Medical Center (LUMC) in Leiden, Netherlands. Here, I focused on characterizing CRB1-rodent models, CRB1-patient induced pluripotent stem cell (iPSC) retinal organoids, and AAV-mediated gene therapies for CRB1-hereditary retinopathies. In 2019, I secured a junior researcher position through the Call to Scientific Employment Stimulus - 2017 (CEEC2017-IND) at the Coimbra Institute for Clinical and Biomedical Research (iCBR) in Portugal. In 2023, I attained an assistant researcher position through the Call to Scientific Employment Stimulus - 5th edition, followed by a fixed-term contract as an Assistant Researcher at the University of Coimbra later in the same year. My prolific publication record includes 31 papers in international peer-reviewed journals, 1 editorial, and 4 book chapters. As of October 2024, these works have garnered over 1175 citations, resulting in an h-index of 18 on Scopus. Noteworthy publications include contributions to high-impact factor journals in Ophthalmology, Human Genetics, Stem Cells, and Neurosciences. Beyond publications, I presented my work at international congresses, delivered presentations at national and international meetings, and received four international travel grants. In 2016, I received the Donders prize for the best PhD thesis in ophthalmology in the Netherlands and the Antioxidants 2020 Outstanding Review Award. I actively contribute to the academic community as a reviewer for esteemed journals, including Autophagy, Transl Neurodegener, and PLoS ONE. I served as a guest editor for a special issue in Antioxidants and am a member of the Antioxidants (MDPI) reviewer board. My commitment to research is evident in securing approximately €947k in competitive funding, serving as the Principal Investigator for €75k and Co-Principal Investigator for €876k. Additionally, I contributed approximately €520k as human resources to various research initiatives. I played a pivotal role in mentoring, supervising 2 MSc students, guiding 14 undergraduate trainees, and lecturing in postgraduate courses at the University of Coimbra. In 2021, I founded the CRB1.Portugal network, dedicated to identifying Portuguese CRB1-patients and raising awareness about genetic retinopathies. I actively participate in science communication, engaging in events such as World Sight Day, European Researchers Night, and Brain Awareness Week.
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Identificação

Identificação pessoal

Nome completo
Celso Henrique Freitas Alves

Nomes de citação

  • Alves, C. Henrique
  • Alves, Celso Henrique
  • Alves, CH

Identificadores de autor

Ciência ID
B61F-6376-4B09
ORCID iD
0000-0001-9776-5701
Google Scholar ID
QQHar1YAAAAJ
Researcher Id
AAH-3017-2019
Scopus Author Id
24376433800

Endereços de correio eletrónico

  • chalves.icbr@gmail.com (Profissional)
  • chalves@fmed.uc.pt (Profissional)

Moradas

  • Polo III - Health Sciences Campus • Azinhaga Santa Comba, Celas , 3000-548, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Genética e Hereditariedade
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador independente (B2) Utilizador independente (B1) Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador elementar (A1)
Holandês Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2009/01/14 - 2014/05/19
Concluído
 Neurosciences (Doctor of Philosophy)
Nederlands Herseninstituut, Países Baixos

Vrije Universiteit Amsterdam, Países Baixos
"The Crumbs Complex in the retina. From animal models to function" (TESE/DISSERTAÇÃO)
2007/09/12 - 2008/07/15
Concluído
 Biochemistry (Mestrado)
Especialização em Molecular Biology
Universidade da Beira Interior, Portugal
"Androgen receptor is expressed in murine choroid plexuses and downregulated by 5a-dihydrotestosterone in male and female mice." (TESE/DISSERTAÇÃO)
 17
2000/10/09 - 2005/09/16
Concluído
 Biochemistry (Licenciatura)
Especialização em Molecular Biology
Universidade da Beira Interior, Portugal
"Cloning, characterization of SMP30 in the rat prostate." (TESE/DISSERTAÇÃO)
 14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/09/28 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
CNC.IBILI, Portugal
(...)
2023/05/31 - 2023/09/27 Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
CNC.IBILI, Portugal
(...)
2019/04/17 - 2023/05/30 Investigador Contratado (Investigação) CNC.IBILI, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/03/16 - 2018/09/30 Pós-doutorado (Investigação) Leids Universitair Medisch Centrum, Países Baixos
2014/03/06 - 2016/03/05 Pós-doutorado (Investigação) Erasmus MC, Países Baixos
2009/01/14 - 2014/01/13 Investigador (Investigação) Nederlands Herseninstituut, Países Baixos
2006/01/06 - 2008/07/31 Investigador (Investigação) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projetos

Bolsa

Designação Financiadores
2024/04/01 - 2026/03/31 “EYS on” gene editing for Retinitis Pigmentosa 25
2023
Co-Investigador Responsável (Co-IR)
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
European Society of Retina Specialists
Em curso
2018/02 - 2022/02 Gene Editing in iPS derived Human Retinal Organoids
NA
Outra
Stichting Uitzicht
2018/09/01 - 2019/09/01 A preclinical vision testing street for rodent
Uitzhich-06
Investigador responsável
Leids Universitair Medisch Centrum, Países Baixos
 Stichting Uitzicht
Concluído
2006/01 - 2008/06 Regulation of the levels of human and mouse TTR in the liver and choroid plexus by steroid hormones
POCI/SAU-NEU/55380/2004
Bolseiro de Investigação
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2023/05 - 2023/09 EYS on Retinitis Pigmentosa 25
2022.00041.CEECIND
 Fundação para a Ciência e a Tecnologia
2019/02 - 2022/02 PINK1/PARKIN-signalling as a potential therapeutic target to halt microglia-mediated inflammation and retinal degeneration in age-related macular degeneration (AMD)
CEECIND/00886/2017
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em conferência
  1. Xu, X; Davelaar, N; Otten-Mus, A-M; Asmawidjaja, PS; Braanker, H den; Alves, H; Hamburg, JP van; et al. "AB0033 The identification of IL-17A+, IL-17RA+ and IL-17RC+ lymphoid and myeloid cells in blood of treatment naÏve early and in synovial fluid of established psoriatic arthritis patients". 2017.
    10.1136/annrheumdis-2017-eular.5916
Artigo em revista
  1. Maria Franca; Joana Providência; Guilherme Castela; Daniela Patrício; Inês Santos Sousa; António F Ambrósio; Henrique Alves (CH ALVES); João Pedro Marques. "CLINICAL AND HISTOPATHOLOGICAL FINDINGS IN JALILI SYNDROME". Ophthalmology Retina (2024): http://dx.doi.org/10.1016/j.oret.2024.11.002.
    10.1016/j.oret.2024.11.002
  2. Nuno Gouveia; Oluji Chukwunalu; Carolina Oliveira; Henrique Alves (CH ALVES); Silva R;; Joaquim N Murta; João Pedro Marques. "Exploring self-reported visual function and vision-related anxiety in patients with RPGR-associated retinal degeneration". Scientific Reports (2024): http://dx.doi.org/10.1038/s41598-024-66170-2.
    10.1038/s41598-024-66170-2
  3. João Pedro Marques; Machado Soares R; Simão S; Abuzaitoun R; Andrews C; Alves CH; Ambrósio AF; et al. "Self-reported visual function and psychosocial impact of visual loss in EYS-associated retinal degeneration in a Portuguese population.". Ophthalmic genetics (2023): https://doi.org/10.1080/13816810.2023.2191708.
    10.1080/13816810.2023.2191708
  4. Soares RM; Carvalho AL; Simão S; Soares CA; Raimundo M; Alves CH; Ambrósio AF; et al. "EYS-ASSOCIATED RETINAL DEGENERATION: NATURAL HISTORY, GENETIC LANDSCAPE AND PHENOTYPIC SPECTRUM.". Ophthalmology. Retina (2023): https://doi.org/10.1016/j.oret.2023.02.001.
    10.1016/j.oret.2023.02.001
  5. Inês Ramos Rego; Daniela Silverio; Maria Isabel Eufrásio; Sandra Sofia Pinhanços; Bruna Lopes da Costa; José Carlos Santos Teixeira; Hugo Fernandes; et al. "TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status". Antioxidants (2023): https://www.mdpi.com/2076-3921/12/2/381.
    10.3390/antiox12020381
  6. Peter M.J. Quinn; António F Ambrósio; Henrique Alves (CH ALVES). "Oxidative Stress, Neuroinflammation and Neurodegeneration: The Chicken, the Egg and the Dinosaur". Antioxidants (2022): https://www.mdpi.com/2076-3921/11/8/1554.
    10.3390/antiox11081554
  7. Alves, C. Henrique. "IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-89625-2.
    10.1038/s41598-021-89625-2
  8. Alves, C. Henrique. "TRAP1 in Oxidative Stress and Neurodegeneration". Antioxidants 10 11 (2021): 1829-1829. http://dx.doi.org/10.3390/antiox10111829.
    10.3390/antiox10111829
  9. Buck, Thilo M.; Vos, Rogier M.; Alves, C. Henrique; Wijnholds, Jan. "AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model". Molecular Therapy - Methods & Clinical Development 20 (2021): 423-441. http://dx.doi.org/10.1016/j.omtm.2020.12.012.
    No prelo • 10.1016/j.omtm.2020.12.012
  10. Nanda Boon; Henrique Alves (CH ALVES); Aat A. Mulder; Charlotte A. Andriessen; Thilo M. Buck; Peter M.J. Quinn; Rogier M. Vos; et al. "Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1". International Journal of Molecular Sciences 22 7 (2021): 3563. https://www.mdpi.com/1422-0067/22/7/3563.
    Acesso aberto • Publicado • 10.3390/ijms22073563
  11. Alves, C. Henrique. "PINK1/PARKIN signalling in neurodegeneration and neuroinflammation.". Acta neuropathologica communications (2020): https://doi.org/10.1186/s40478-020-01062-w.
    10.1186/s40478-020-01062-w
  12. Alves, C. Henrique. "Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration". Cells (2020): http://dx.doi.org/10.3390/cells9051217.
    10.3390/cells9051217
  13. Alves, C. Henrique. "Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal". PLOS Biology (2020): http://dx.doi.org/10.1371/journal.pbio.3000470.
    10.1371/journal.pbio.3000470
  14. Alves, C. Henrique. "CD4+ CCR6+ T cells, but not gd T cells, are important for the IL-23R-dependent progression of antigen-induced inflammatory arthritis in mice.". European journal of immunology 50 2 (2020): 245-255. https://doi.org/10.1002/eji.201948112.
    10.1002/eji.201948112
  15. Alves, C. Henrique. "CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity". International Journal of Molecular Sciences (2019): http://dx.doi.org/10.3390/ijms20174069.
    10.3390/ijms20174069
  16. Peter M. Quinn; Thilo M. Buck; Aat A. Mulder; Charlotte Ohonin; C. Henrique Alves; Rogier M. Vos; Monika Bialecka; et al. "Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5". Stem Cell Reports (2019): https://doi.org/10.1016%2Fj.stemcr.2019.03.002.
    10.1016/j.stemcr.2019.03.002
  17. Quinn PM; Mulder AA; Henrique Alves C; Desrosiers M; Vries SI; Klooster J; Dalkara D; et al. "Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype.". Human molecular genetics (2018): http://europepmc.org/abstract/med/30239717.
    10.1093/hmg/ddy337
  18. Alves, Celso. "NTPDase2 as a Surface Marker to Isolate Flow Cytometrically a Müller Glial Cell Enriched Population from Dissociated Neural Retinae". Journal of Neuroscience and Neurosurgery (2018): https://www.boffinaccess.com/open-access-journals/journal-of-neuroscience-and-neurosurgery/jan-wijnholds-jnn-1-117.php.
    10.31021/jnn.20181117
  19. Quinn PM; Alves CH; Klooster J; Wijnholds J. "CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function.". Human molecular genetics (2018): http://europepmc.org/abstract/med/29893966.
    10.1093/hmg/ddy194
  20. Dudok, J.J.; Murtaza, M.; Henrique Alves, C.; Rashbass, P.; Wijnholds, J.. "Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon". Neuroscience Research 108 (2016): 12-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973121794&partnerID=MN8TOARS.
    10.1016/j.neures.2016.01.001
  21. Alves, C.H.; Farrell, E.; Vis, M.; Colin, E.M.; Lubberts, E.. "Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside—a Comprehensive Review". Clinical Reviews in Allergy and Immunology (2015): 1-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949527714&partnerID=MN8TOARS.
    10.1007/s12016-015-8522-7
  22. Alves CH; Ober-Blöbaum JL; Brouwers-Haspels I; Asmawidjaja PS; Mus AM; Razawy W; Molendijk M; Clausen BE; Lubberts E. "Dendritic Cell-Specific Deletion of ß-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis.". (2015): http://europepmc.org/abstract/med/26587585.
    10.1371/journal.pone.0142972
  23. Alves, C.H.; Pellissier, L.P.; Vos, R.M.; Garrido, M.G.; Sothilingam, V.; Seide, C.; Beck, S.C.; et al. "Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa". Human Molecular Genetics 23 13 (2014): 3384-3401. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902342968&partnerID=MN8TOARS.
    10.1093/hmg/ddu048
  24. Alves, C.H.; Pellissier, L.P.; Wijnholds, J.. "The CRB1 and adherens junction complex proteins in retinal development and maintenance". Progress in Retinal and Eye Research 40 (2014): 35-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899107438&partnerID=MN8TOARS.
    10.1016/j.preteyeres.2014.01.001
  25. Pellissier, L.P.; Quinn, P.M.; Henrique Alves, C.; Vos, R.M.; Klooster, J.; Flannery, J.G.; Alexander Heimel, J.; Wijnholds, J.. "Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models". Human Molecular Genetics 24 11 (2014): 3104-3118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930711055&partnerID=MN8TOARS.
    10.1093/hmg/ddv062
  26. Alves, C.H.; Sanz sanz, A.; Park, B.; Pellissier, L.P.; Tanimoto, N.; Beck, S.C.; Huber, G.; et al. "Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene". Human Molecular Genetics 22 1 (2013): 35-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871222436&partnerID=MN8TOARS.
    10.1093/hmg/dds398
  27. Alves, C.H.; Bossers, K.; Vos, R.M.; Essing, A.H.W.; Swagemakers, S.; Van Der Spek, P.J.; Verhaagen, J.; Wijnholds, J.. "Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891919002&partnerID=MN8TOARS.
    10.1371/journal.pone.0082532
  28. Pellissier, L.P.; Alves, C.H.; Quinn, P.M.; Vos, R.M.; Tanimoto, N.; Lundvig, D.M.S.; Dudok, J.J.; et al. "Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis". PLoS Genetics 9 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84892774024&partnerID=MN8TOARS.
    10.1371/journal.pgen.1003976
  29. Park, B.; Alves, C.H.; Lundvig, D.M.; Tanimoto, N.; Beck, S.C.; Huber, G.; Richard, F.; et al. "PALS1 is essential for retinal pigment epithelium structure and neural retina stratification". Journal of Neuroscience 31 47 (2011): 17230-17241. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855184636&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.4430-11.2011
  30. Quintela, T.; Gonçalves, I.; Martinho, A.; Alves, C.H.; Saraiva, M.J.; Rocha, P.; Santos, C.R.A.. "Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor". Journal of Molecular Neuroscience 44 3 (2011): 152-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054082420&partnerID=MN8TOARS.
    10.1007/s12031-010-9398-x
  31. Alves, C.H.; Gonçalves, I.; Socorro, S.; Baltazar, G.; Quintela, T.; Santos, C.R.A.. "Androgen receptor is expressed in murine choroid plexus and downregulated by 5a-Dihydrotestosterone in male and female mice". Journal of Molecular Neuroscience 38 1 (2009): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949213641&partnerID=MN8TOARS.
    10.1007/s12031-008-9157-4
  32. Quintela, T.; Gonçalves, I.; Baltazar, G.; Alves, C.H.; Saraiva, M.J.; Santos, C.R.A.. "17ß-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway". Cellular and Molecular Neurobiology 29 4 (2009): 475-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449156413&partnerID=MN8TOARS.
    10.1007/s10571-008-9339-1
  33. Quintela, T.; Alves, C.H.; Gonçalves, I.; Baltazar, G.; Saraiva, M.J.; Santos, C.R.A.. "5a-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway". Brain Research 1229 (2008): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-49849091809&partnerID=MN8TOARS.
    10.1016/j.brainres.2008.06.095
  34. Gonçalves, I.; Alves, C.H.; Quintela, T.; Baltazar, G.; Socorro, S.; Saraiva, M.J.; Abreu, R.; Santos, C.R.A.. "Transthyretin is up-regulated by sex hormones in mice liver". Molecular and Cellular Biochemistry 317 1-2 (2008): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149110036&partnerID=MN8TOARS.
    10.1007/s11010-008-9841-2
Capítulo de livro
  1. Alves, C. Henrique; Wijnholds, Jan. "Microglial Cell Dysfunction in CRB1-Associated Retinopathies". In Advances in Experimental Medicine and Biology, 159-163. Springer International Publishing, 2019.
    10.1007/978-3-030-27378-1_26
  2. Alves, Celso. "AAV-Mediated Gene Therapy for CRB1-Hereditary Retinopathies". 2018.
    10.5772/intechopen.79308
  3. Alves CH; Wijnholds J. "AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa.". In Methods in molecular biology (Clifton, N.J.). 2018.
    10.1007/978-1-4939-7522-8_10
  4. Razawy W; Alves CH; Molendijk M; Asmawidjaja PS; Mus AMC; Lubberts E. "Experimental Arthritis Mouse Models Driven by Adaptive and/or Innate Inflammation.". In Methods in molecular biology (Clifton, N.J.). 2017.
    10.1007/978-1-4939-6786-5_27
Poster em conferência
  1. Alves, C. Henrique; Marques JP; Carvalho AL, ; Simão S; Azevedo Soares C; Raimundo M; Ambrósio A; et al. "EYS-associated retinal degeneration natural history and genetic landscape in a Portuguese Cohort". Trabalho apresentado em XXth international symposium on retinal degeneration - RD2023, 2023.
  2. Pinhanços S; Oliveira J; Santos J; Alves, CH; Gotthard M; Ferreira L; Jones J; Fernandes, H.A.M.. "Identification of miRNAs able to protect beta-cells from glucolipotoxicity using a high throughput screening approach". Trabalho apresentado em European Tissue Repair Society (ETRS) & Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC) joint meeting, 2023.
  3. Pinhanços, SS or Pinhanços, SM; Oliveira J; Santos J; Alves, CH; Gotthard M; Ferreira L; Jones J; Fernandes H. "Identification of miRNAs able to protect beta-cells from glucolipotoxicity using a high throughput screening approach.". Trabalho apresentado em European Association for the Study of Diabetes (EASD) Annual Meeting., 2023.
  4. Alves, C. Henrique; Boon, N.; Mulder, A.A.; Buck, T.M; Quinn, P.M.J.; Jost, CR.; Wijnhols, J. "Exploring Retinal Gene Therapy Using Adeno-Associated Viral (AAV) Vectors in Crb1 Mutant Rats". Trabalho apresentado em 2020 ASGCT Annual, 2020.
    10.1016/j.ymthe.2020.04.019
  5. Alves, C. Henrique; Boon, N; Wijnholds, J. "Adeno-associated viral (AAV) vector tropism in the young Brown Norway rat retina". Trabalho apresentado em 2019 ARVO Annual Meeting, 2019.
Recurso online
  1. Campos, Elisa J.; Alves, Celso Henrique. Eye health awareness on behalf the World Sight Day, in collaboration with IAPB - International Agency for the Prevention of Blindness on iCBR social media.. 2021. https://www.facebook.com/iCBR.FMUC.
Resumo em conferência
  1. Alves, C. Henrique. "A3.08 Exploring the collagen induced arthritis model for arthralgia". 2016.
    10.1136/annrheumdis-2016-209124.85
  2. Alves, C. Henrique. "A2.31 Immunisation with type II collagen (CII) alters the IL-23 receptor expression profile compared to naïve conditions". 2016.
    10.1136/annrheumdis-2016-209124.66
  3. Alves, C. Henrique. "A2.34 Specific deletion of ß-catenin signalling in dendritic cells results in lower Treg expression without influencing the severity of collagen-induced arthritis". 2015.
    10.1136/annrheumdis-2015-207259.69
Tese / Dissertação
  1. Alves, C. Henrique. "The Crumbs complex in the retina: from animal models to function". Doutoramento, 2014. http://rgdoi.net/10.13140/RG.2.1.4892.1760.
    10.13140/RG.2.1.4892.1760
  2. Alves, Celso Henrique Freitas; Santos, Cecília Reis Alves dos. "Androgen receptor is expressed in murine choroid plexuses and downregulated by 5?-dihydrotestosterone in male and female mice". Mestrado, 2008. http://hdl.handle.net/10400.6/1057.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/07/20 CRB1-inherited retinal dystrophies: Milestones towards a gene therapy treatment for Retinitis Pigmentosa CIBB Neuroscience and Disease 2020 Online retreat
Luís P. de Almeida (Coimbra, Portugal)
2019/05 CRB1-inherited retinal dystrophies Milestones towards a gene therapy treatment for Retinitis Pigmentosa. CNC.IBILI Seminars
(Cantanhede, Portugal)
2018/05 Ablation of CRB2 in rod photoreceptors with concomitant loss of CRB1 in Müller glial cells mimics retinitis pigmentosa. ARVO 2018 Annual Meeting: Stand strong for science: Stand for strong vision science
(Honolulu, Estados Unidos)
2018/03 From animal models to gene therapy for retinal blindness Netherlands Society of Gene and Cell Therapy (NVGCT) Spring symposium
NVGCT (Lunteren, Países Baixos)
2015/12 Dendritic cell-specific deletion of ß-catenin results in fewer regulatory T-cells without exacerbating autoimmune collagen-induced arthritis NVVI Winter School 2015
(Noordwijkerhout, Países Baixos)
2015/05 The Crumbs complex in the retina. Milestones towards a treatment for retinitis pigmentosa. 9th Seminar cycles
CICS - UBI (Covilhã, Portugal)
2014/05 Targeted ablation of Crb2 in photoreceptor cells induces Retinitis Pigmentosa ARVO 2014 Annual Meeting: Leading Eye and Vision Research.
(Orlando, Estados Unidos)
2013/06 Crumbs homologues 1 and 2 in retinal development and maintenance Young Researcher Vision Camp 2013
(Leibertingen, Alemanha)
2012/05 Crumbs homologues 1 and 2 in retinal development and maintenance ARVO 2012 Annual Meeting: Translational research, seeing the possibilities
(Fort Lauderdale, Estados Unidos)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021/11/30 - 2021/11/30 Organization of the V Symposium of the Portuguese Glial Network (2021/11/30 - 2021/11/30)
Simpósio (Membro da Comissão Organizadora)
 Universidade de Coimbra Faculdade de Medicina, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2021/11/19 - Atual A short talk about what we expect from students during their internship.
Mesa-redonda
Biochemistry student association, Portugal
2021/06/09 - 2021/06/09 Webinar about our brain for students of the 6º grade from the school "Agrupamento Vieira de Araújo" from Vieira do Minho.
Seminário
 How our brain works
Agrupamento Vieira de Araújo, Portugal
2021/03/22 - 2021/03/22 Webinar inserted in the activities of the "Brain week". Brain week
Universidade de Coimbra, Portugal
2019/10/11 - 2019/10/11 Exposition of scientific images and realization of several activities at "Alma Shopping centre" (Coimbra) to celebrate the world sight day.
Exposição
 Word sight day
Universidade de Coimbra Faculdade de Medicina, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020/02/24 - Atual Antioxidants (2076-3921) MDPI AG

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/12/10 - 2020/12/18 Laboratorial demonstration inserted on the Research Methods and Techniques (RMT) course Biomedical research (Mestrado) Universidade de Coimbra, Portugal
2020/11/11 - 2020/11/11 Lecture at Research Methods and Techniques (RMT). Vision Research Biomedical research (Mestrado) Universidade de Coimbra, Portugal
2020/06/08 - 2020/06/22 Laboratorial demonstration part of the Cellular regulation course Biomedical research (Mestrado) Universidade de Coimbra, Portugal
2019/12/01 - 2019/12/15 Laboratorial demonstration: Research Methods and Techniques (RMT) Biomedical research (Mestrado) Universidade de Coimbra, Portugal
2019/11/22 - 2019/11/22 Lecture at Research Methods and Techniques (RMT) course. Biomedical research (Mestrado) Universidade de Coimbra, Portugal
2018/11/08 - 2018/11/08 Lecture given at Research Methods and Techniques (RMT). Part of the Master program in biomedical research (Mestrado) Universidade de Coimbra, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2021/02/26 Newspaper interview published after receiving the 2020 Antioxidants Reviewer Awards Notícias de Fafe
2016/04/25 Interview performed by Elsa Lima from the "Notícias de Fafe", a weekly newspaper. The interview occurred after I received the Donders Prize in 2016. This prize is awarded to the best PhD thesis in the field of ophthalmology in the Netherlands. Notícias de Fafe

Membro de associação

Nome da associação Tipo de participação
2021/04/08 - Atual Founder of the CRB1.PORTUGAL network. This network is devoted to connect CRB1 patients, patient organizations and provide information about the new development in the ophthalmology field. Founder

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2024/01/02 - Atual Gene (0378-1119) Elsevier
2023/02/20 - Atual BBA - Molecular Cell Research Elsevier
2021/09/21 - Atual Molecular Therapy: Methods & Clinical Development (2329-0501) Elsevier
2021/09/16 - Atual eBioMedicine ( 2352-3964) The Lancet
2021/06/14 - Atual The FASEB Journal (1530-6860)
2020/12/20 - Atual Acta Biomaterialia ( 1742-7061) Elsevier
2020/12/20 - Atual Translational Neurodegeneration (2047-9158) BMC - Springer nature
2020/12/02 - Atual Life (2075-1729) MDPI AG
2020/12/01 - Atual Translational Neurodegeneration (2047-9158) Springer nature
2020/11/19 - Atual Pharmaceuticals ( 1424-8247) MDPI AG
2020/10/01 - Atual IJMS (1422-0067)) MDPI AG
2020/08/05 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2020/06/20 - Atual Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy (1178-7007) Dove Medical Press
2020/06/03 - Atual PeerJ — the Journal of Life and Environmental Sciences
2020/05/19 - Atual PLoS ONE PLoS
2019/12/16 - Atual Cells (2073-4409) MDPI
2022/01/24 - 2022/01/24 Autophagy (1554-8635) Taylor & Francis
Distinções

Prémio

2024 Best Translational Research Publication
Unidade Local de Saúde de Coimbra, Portugal
2021 Antioxidants 2020 Oustanding Review Award
Antioxidants Journal, Suiça
2016 Donders 2016 award, best PhD thesis in the field of ophthalmology in the Netherlands

Outra distinção

2020 4th place: Publication of the Year 2019
vision-research.eu, Bélgica
2018 Fritz Tobler travel grant
Fritz Tobler-Stiftung, Suiça
2017 Nomination for the award 'Ardina d'Ouro', in the category of education
2015 EULAR Travel Grant
2014 ARVO International Travel Grant
2014 Reumafonds Travel Grant
Reumafonds, Países Baixos
2011 Poster prize (Hot topic subject)