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After completing his university studies of Biology at the Dresden University of Technology, Germany, in 2005, Kristof Zarschler started his doctoral thesis at the Department of NanoBiotechnology of the University of Natural Resources and Applied Life Sciences Vienna, Austria. He received his PhD degree with distinction in 2009 and came back to the Dresden University of Technology, Germany, where he joined the group of Prof. Gerhard Rödel as research associate (2010). Since 2011, Kristof works as research associate at the Institute of Radiopharmaceutical Cancer Research of the Helmholtz-Zentrum Dresden-Rossendorf, Germany. His research interests focus on the bio-nano-interactions of nanomaterials with biomolecules and cells. At the Helmholtz-Zentrum Dresden-Rossendorf, Kristof is mainly involved in the development of precision nanomaterials as cancer targeted radiotheranostics. Furthermore, the application of tailored antibody fragments as diagnostic and therapeutic agents or as targeting moieties for nanoparticles represents one of the focal points of his scientific work.
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Identificação

Identificação pessoal

Nome completo
Zarschler Kristof

Nomes de citação

  • Kristof, Zarschler

Identificadores de autor

Ciência ID
BA1C-45CF-435E
ORCID iD
0000-0002-7571-4732

Telefones

Telefone
  • (+49) 351260 Ext.: 3678 (Profissional)

Moradas

  • Bautzner Landstr. 400, 01328, Dresden, Dresden, Alemanha (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Alemão (Idioma materno)
Formação
Grau Classificação
2009
Concluído
 Dr. nat. techn. (Doktor (PhD))
Universität für Bodenkultur Department für NanoBiotechnologie, Áustria
"Development of a model organism for bacterial surface layer protein O-glycosylation" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/12 - Atual Investigador (Investigação) Helmholtz-Zentrum Dresden-Rossendorf Institut für Radiopharmazeutische Krebsforschung, Alemanha
2010 - 2011/11 Pós-doutorado (Investigação) Technische Universität Dresden Fakultät Mathematik und Naturwissenschaften, Alemanha
Produções

Publicações

Artigo em revista
  1. Singh, Garima; Zarschler, Kristof; Hunoldt, Sebastian; Martínez, Irma Ivette Santana; Ruehl, Carmen L.; Matterna, Madlen; Bergmann, Ralf; et al. "Versatile Bispidine-Based Bifunctional Chelators for 64 Cu II -Labelling of Biomolecules". Chemistry – A European Journal 26 9 (2020): 1989-2001. http://dx.doi.org/10.1002/chem.201904654.
    Acesso aberto • 10.1002/chem.201904654
  2. Pant, Kritee; Neuber, Christin; Zarschler, Kristof; Wodtke, Johanna; Meister, Sebastian; Haag, Rainer; Pietzsch, Jens; Stephan, Holger. "Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging". Small 16 7 (2020): 1905013. http://dx.doi.org/10.1002/smll.201905013.
    Acesso aberto • Publicado • 10.1002/smll.201905013
  3. Karges, Johannes; Jakubaszek, Marta; Mari, Cristina; Zarschler, Kristof; Goud, Bruno; Stephan, Holger; Gasser, Gilles. "Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective Ru II Polypyridyl–Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy". ChemBioChem 21 4 (2019): 531-542. http://dx.doi.org/10.1002/cbic.201900419.
    Acesso aberto • 10.1002/cbic.201900419
  4. Peewasan, Krisana; Merkel, Marcel P.; Zarschler, Kristof; Stephan, Holger; Anson, Christopher E.; Powell, Annie K.. "Tetranuclear Cu(ii)-chiral complexes: synthesis, characterization and biological activity". RSC Advances 9 42 (2019): 24087-24091. http://dx.doi.org/10.1039/c9ra03586a.
    Acesso aberto • Publicado • 10.1039/c9ra03586a
  5. Nsubuga, Anne; Zarschler, Kristof; Sgarzi, Massimo; Graham, Bim; Stephan, Holger; Joshi, Tanmaya. "Towards Utilising Photocrosslinking of Polydiacetylenes for the Preparation of “Stealth” Upconverting Nanoparticles". Angewandte Chemie International Edition 57 49 (2018): 16036-16040. http://dx.doi.org/10.1002/anie.201811003.
    Publicado • 10.1002/anie.201811003
  6. Haider, Ali; Zarschler, Kristof; Joshi, Sachin A.; Smith, Rachelle M.; Lin, Zhengguo; Mougharbel, Ali S.; Herzog, Utta; et al. "Preyssler-Pope-Jeannin Polyanions [NaP5 W30 O110 ]14- and [AgP5 W30 O110 ]14- : Microwave-Assisted Synthesis, Structure, and Biological Activity". Zeitschrift für anorganische und allgemeine Chemie 644 14 (2018): 752-758. http://dx.doi.org/10.1002/zaac.201800113.
    Acesso aberto • Publicado • 10.1002/zaac.201800113
  7. Nsubuga, Anne; Sgarzi, Massimo; Zarschler, Kristof; Kubeil, Manja; Hübner, René; Steudtner, Robin; Graham, Bim; Joshi, Tanmaya; Stephan, Holger. "Facile preparation of multifunctionalisable ‘stealth’ upconverting nanoparticles for biomedical applications". Dalton Transactions 47 26 (2018): 8595-8604. http://dx.doi.org/10.1039/c8dt00241j.
    Acesso aberto • Publicado • 10.1039/c8dt00241j
  8. Bergmann, Ralf; Kubeil, Manja; Zarschler, Kristof; Chhabra, Sandeep; Tajhya, Rajeev B.; Beeton, Christine; Pennington, Michael W.; et al. "Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/s41598-017-03998-x.
    Publicado • 10.1038/s41598-017-03998-x
  9. Kunz-Schughart, Leoni A.; Dubrovska, Anna; Peitzsch, Claudia; Ewe, Alexander; Aigner, Achim; Schellenburg, Samuel; Muders, Michael H.; et al. "Nanoparticles for radiooncology: Mission, vision, challenges". Biomaterials 120 (2017): 155-184. http://dx.doi.org/10.1016/j.biomaterials.2016.12.010.
    Publicado • 10.1016/j.biomaterials.2016.12.010
  10. Pant, Kritee; Pufe, Johanna; Zarschler, Kristof; Bergmann, Ralf; Steinbach, Jörg; Reimann, Sabine; Haag, Rainer; Pietzsch, Jens; Stephan, Holger. "Surface charge and particle size determine the metabolic fate of dendritic polyglycerols". Nanoscale 9 25 (2017): 8723-8739. http://dx.doi.org/10.1039/c7nr01702b.
    Acesso aberto • 10.1039/c7nr01702b
  11. Pombo-García, Karina; Weiss, Stephan; Zarschler, Kristof; Ang, Ching-Seng; Hübner, René; Pufe, Johanna; Meister, Sebastian; et al. "Zwitterionic Polymer-Coated Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with Low Protein Interaction and High Biocompatibility". ChemNanoMat 2 10 (2016): 959-971. http://dx.doi.org/10.1002/cnma.201600233.
    Acesso aberto • 10.1002/cnma.201600233
  12. Zarschler, Kristof; Rocks, Louise; Licciardello, Nadia; Boselli, Luca; Polo, Ester; Garcia, Karina Pombo; De Cola, Luisa; Stephan, Holger; Dawson, Kenneth A.. "Ultrasmall inorganic nanoparticles: State-of-the-art and perspectives for biomedical applications". Nanomedicine: Nanotechnology, Biology and Medicine 12 6 (2016): 1663-1701. http://dx.doi.org/10.1016/j.nano.2016.02.019.
    10.1016/j.nano.2016.02.019
  13. Patra, Malay; Zarschler, Kristof; Pietzsch, Hans-Jürgen; Stephan, Holger; Gasser, Gilles. "New insights into the pretargeting approach to image and treat tumours". Chemical Society Reviews 45 23 (2016): 6415-6431. http://dx.doi.org/10.1039/c5cs00784d.
    Publicado • 10.1039/c5cs00784d
  14. Kubeil, Manja; Zarschler, Kristof; Pietzsch, Jens; Kraus, Werner; Comba, Peter; Stephan, Holger. "Copper(II) Cyclam Complexes with N-­Propionic Acid Pendant Arms". European Journal of Inorganic Chemistry 2015 24 (2015): 4013-4023. http://dx.doi.org/10.1002/ejic.201500510.
    10.1002/ejic.201500510
  15. Leonidova, Anna; Foerster, Christian; Zarschler, Kristof; Schubert, Maik; Pietzsch, Hans-Jürgen; Steinbach, Jörg; Bergmann, Ralf; et al. "In vivo demonstration of an active tumor pretargeting approach with peptide nucleic acid bioconjugates as complementary system". Chemical Science 6 10 (2015): 5601-5616. http://dx.doi.org/10.1039/c5sc00951k.
    10.1039/c5sc00951k
  16. Comba, Peter; Kubeil, Manja; Pietzsch, Jens; Rudolf, Henning; Stephan, Holger; Zarschler, Kristof. "Bispidine Dioxotetraaza Macrocycles: A New Class of Bispidines for 64Cu PET Imaging". Inorganic Chemistry 53 13 (2014): 6698-6707. http://dx.doi.org/10.1021/ic500476u.
    10.1021/ic500476u
  17. García, Karina Pombo; Zarschler, Kristof; Barbaro, Lisa; Barreto, José A.; O'Malley, William; Spiccia, Leone; Stephan, Holger; Graham, Bim. "Zwitterionic-Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System". Small 10 13 (2014): 2516-2529. http://dx.doi.org/10.1002/smll.201303540.
    Acesso aberto • 10.1002/smll.201303540
  18. Kubeil, Manja; Zarschler, Kristof; Steinbach, Joerg; Stephan, Holger. "Kinetic inertness evaluation of copper complexes using gel electrophoresis techniques". Nuclear Medicine and Biology 41 7 (2014): 633-634. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339599500086&KeyUID=WOS:000339599500086.
    10.1016/j.nucmedbio.2014.05.028
  19. Zarschler, Kristof; Zscheppang, Katja; Kapplusch, Franz; Cordes, Nils; Stephan, Holger. "Single-domain antibodies: Next-generation targeting vectors for molecular imaging". Nuclear Medicine and Biology 41 7 (2014): 628-628. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339599500066&KeyUID=WOS:000339599500066.
    10.1016/j.nucmedbio.2014.05.015
  20. Zarschler, K.; Prapainop, K.; Mahon, E.; Rocks, L.; Bramini, M.; Kelly, P. M.; Stephan, H.; Dawson, K. A.. "Diagnostic nanoparticle targeting of the EGF-receptor in complex biological conditions using single-domain antibodies". Nanoscale 6 11 (2014): 6046-6056. http://dx.doi.org/10.1039/c4nr00595c.
    Acesso aberto • 10.1039/c4nr00595c
  21. Zarschler, K.; Kubeil, M.; Stephan, H.. "Establishment of two complementary in vitro assays for radiocopper complexes achieving reliable and comparable evaluation of in vivo stability". RSC Advances 4 20 (2014): 10157. http://dx.doi.org/10.1039/c3ra47302c.
    Acesso aberto • Publicado • 10.1039/c3ra47302c
  22. Zarschler, Kristof; Witecy, Stefanie; Kapplusch, Franz; Foerster, Christian; Stephan, Holger. "High-yield production of functional soluble single-domain antibodies in the cytoplasm of Escherichia coli". Microbial Cell Factories 12 1 (2013): 97. http://dx.doi.org/10.1186/1475-2859-12-97.
    Publicado • 10.1186/1475-2859-12-97
  23. Pombo-García, Karina; Zarschler, Kristof; Barreto, Jose A.; Hesse, Julia; Spiccia, Leone; Graham, Bim; Stephan, Holger. "Design, synthesis, characterisation and in vitro studies of hydrophilic, colloidally stable, 64Cu(ii)-labelled, ultra-small iron oxide nanoparticles in a range of human cell lines". RSC Advances 3 44 (2013): 22443. http://dx.doi.org/10.1039/c3ra43726d.
    Publicado • 10.1039/c3ra43726d
  24. Kothe, Janette; Schroeter, Anna; Zarschler, Kristof; Wersing, Dagmar; Mkandawire, Martin; Ostermann, Kai; Pompe, Wolfgang; Roedel, Gerhard; Gerlach, Gerald. "Optical Biosensor Based on the Dependent Expression of Fluorescent Proteins". Tm-Technisches Messen 79 1 (2012): 60-64. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000299478900010&KeyUID=WOS:000299478900010.
    10.1524/teme.2012.0187
  25. Ristl R; Steiner K; Zarschler K; Zayni S; Messner P; Schäffer C. "The s-layer glycome-adding to the sugar coat of bacteria.". (2011): http://europepmc.org/abstract/med/20871840.
    10.1155/2011/127870
  26. Zarschler, Kristof; Janesch, Bettina; Kainz, Birgit; Ristl, Robin; Messner, Paul; Schaeffer, Christina. "Cell surface display of chimeric glycoproteins via the S-layer of Paenibacillus alvei". Carbohydrate Research 345 10 (2010): 1422-1431. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000280460600025&KeyUID=WOS:000280460600025.
    10.1016/j.carres.2010.04.010
  27. Zarschler, Kristof; Janesch, Bettina; Pabst, Martin; Altmann, Friedrich; Messner, Paul; Schaeffer, Christina. "Protein tyrosine O-glycosylation-A rather unexplored prokaryotic glycosylation system". Glycobiology 20 6 (2010): 787-798. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000277448400014&KeyUID=WOS:000277448400014.
    10.1093/glycob/cwq035
  28. Zarschler, Kristof; Janesch, Bettina; Zayni, Sonja; Schaeffer, Christina; Messner, Paul. "Construction of a Gene Knockout System for Application in Paenibacillus alvei CCM 2051(T), Exemplified by the S-Layer Glycan Biosynthesis Initiation Enzyme WsfP". Applied and Environmental Microbiology 75 10 (2009): 3077-3085. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000265908500011&KeyUID=WOS:000265908500011.
    10.1128/AEM.00087-09
  29. Steiner, Kerstin; Novotny, Rene; Werz, Daniel B.; Zarschler, Kristof; Seeberger, Peter H.; Hofinger, Andreas; Kosma, Paul; Schaeffer, Christina; Messner, Paul. "Molecular basis of S-layer glycoprotein glycan biosynthesis in Geobacillus stearothermophilus". Journal of Biological Chemistry 283 30 (2008): 21120-21133. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000257746100054&KeyUID=WOS:000257746100054.
    10.1074/jbc.M801833200
  30. Messner, Paul; Steiner, Kerstin; Zarschler, Kristof; Schaeffer, Christina. "S-layer nanoglycobiology of bacteria". Carbohydrate Research 343 12 (2008): 1934-1951. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000257823400005&KeyUID=WOS:000257823400005.
    10.1016/j.carres.2007.12.025
  31. Lawen, A; Ly, JD; Lane, DJR; Zarschler, K; Messina, A; De Pinto, V. "Voltage-dependent anion-selective channel 1 (VDAC1) - a mitochondrial protein, rediscovered as a novel enzyme in the plasma membrane". International Journal of Biochemistry & Cell Biology 37 2 (2005): 277-282. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000224909400007&KeyUID=WOS:000224909400007.
    10.1016/j.biocel.2004.05.013
  32. Blecha, A; Zarschler, K; Sjollema, KA; Veenhuis, M; Rodel, G. "Expression and cytosolic assembly of the S-layer fusion protein mSbsC-EGFP in eukaryotic cells". Microbial Cell Factories 4 (2005): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000232805300001&KeyUID=WOS:000232805300001.
    10.1186/1475-2859-4-28