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Ruilong Sheng received his B.Sc degree (Biochemistry) in 2002 from South-Central University for Nationalities, China. In 2008, he obtained his PhD degree (Organic Chemistry) from Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), China. From 2009 to 2011, he conducted postdoctoral research in Organic-Macromolecular chemistry and Biomaterials at Shanghai Institute of Organic Chemistry, CAS, China, then he worked there as an associate research professor. From 2015 to 2017, he was invited to work at Université de Montréal and McGill University, Canada, working on natural product chemistry and nanobiomaterials as an invited scientist/professor. Later, he joined CQM-Centro de Química da Madeira at Universidade da Madeira, Portugal as a Senior researcher (R4, Research Professor) and group leader. Since 2022.06, he has been serving in CQM as a Portugal national FCT fund-granted scientist. His research interests include Organic chemistry, Natural products, Macromolecular/polymer chemistry and physics, Supramolecular chemistry, Green organic synthesis, Fluorescent probes and bioimaging, Biomaterials and Nanobiotechnology. He published 108 papers (with 44 as the first or corresponding author, cited: >3800 times, H-index=34, i10 index = 50, Google Scholar: Ruilong Sheng) on international journals including: Biomaterials, Biosens. Bioelect., Org. Lett., J. Mater. Chem B, Eur. J .Org. Chem, Polym. Chem, Anal. Chem, Coord. Chem. Rev., Mater. Horizon., Chem. Commun., ACS Appl. Mater. Interfaces., Nanomaterials, Rsc Adv., Macromol. Biosci, Bioorg. Med. Chem, Tetrahedron, Int. J. Mol. Sci, and Talanta. He applied 18 patents (9 granted) and published 29 conference abstracts and gave 10 invited lectures. He serves as an active peer reviewer (>260 times review) in many international journals (Web of science: Ruilong Sheng). He also served as an invited editor of international journals including: Front. Chem., Front. Oncol., Nanomaterials, Adv. Polym. Tech., Gen. Chem., Med. Res., and Int. J. Polym. Sci.. More details of Dr. Ruilong Sheng please refers to: https://www.researchgate.net/profile/Ruilong_Sheng or http://orcid.org/0000-0002-3303-3832
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Identificação

Identificação pessoal

Nome completo
Ruilong Sheng
Data de nascimento
1982/01/21
Género
Masculino

Nomes de citação

  • Sheng, Ruilong

Identificadores de autor

Ciência ID
C019-C809-403B
ORCID iD
0000-0002-3303-3832
Google Scholar ID
https://scholar.google.ca/citations?user=YCheaFsAAAAJ&hl=en
Scopus Author Id
7005472737

Telefones

Telefone
  • 29170 Ext.: 5254 (Profissional)

Moradas

  • Campus da Penteada, 9000-390 , Funchal, Madeira Islands, Portugal (Profissional)

Domínios de atuação

  • Ciências Exatas - Química - Química Orgânica
  • Ciências Exatas - Química - Química Física
  • Ciências Exatas - Química - Ciência de Polímeros
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Chinês (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2002/09 - 2008/08
Concluído
 Organic Chemistry (Doctor of Philosophy)
Technical Institute of Physics and Chemistry, China

University of the Chinese Academy of Sciences, China
"Design and Synthesis of Novel Optical Chemosensors for Molecular Recognition" (TESE/DISSERTAÇÃO)
1998/09 - 2002/07
Concluído
 Biochemistry (Bachelor)
South-Central University for Nationalities, China
"Non-isothermal kinetics Study on Thermal Degradation of Purine Antiviral Drugs" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/06 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade da Madeira Centro de Química da Madeira, Portugal
2017/10 - 2022/05 Investigador principal convidado (carreira) (Investigação) Universidade da Madeira Centro de Química da Madeira, Portugal
2016/09 - 2017/09 Investigador principal convidado (carreira) (Investigação) McGill University Department of Bioengineering, Canadá
2011/07 - 2017 Investigador principal (carreira) (Investigação) Shanghai Institute of Organic Chemistry, China
2015/03 - 2016/08 Investigador principal convidado (carreira) (Investigação) Université de Montréal Département de chimie, Canadá
2008/12 - 2011/06 Pós-doutorado (Investigação) Shanghai Institute of Organic Chemistry, China
2008/04 - 2008/12 Assistente de Investigação (carreira) (Investigação) Technical Institute of Physics and Chemistry, China
Projetos

Bolsa

Designação Financiadores
2017/10 - 2021/10 (Marine) Natural product based supramolecular systems for Biomaterials application
ARDITI-2017-ISG-003 (Euro 127,200)
Bolseiro de Cientista Convidado
Universidade da Madeira Centro de Química da Madeira, Portugal
 Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação
Concluído
2019/01/01 - 2019/12/31 Centro de Química da Madeira (Integrated senior researcher of (Marine) Natural product based nanobiomaterials)
UID/QUI/00674/2019
Bolseiro de Integração na Investigação
Universidade da Madeira, Portugal

Universidade da Madeira Centro de Química da Madeira, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/01 - 2017/12 Studies on new supramolecular systems prepared by steroidal compounds and their cellular gene delivery.
21372251
21372251 (RMB 800,000)
Investigador responsável
Shanghai Institute of Organic Chemistry, China
 National Natural Science Foundation of China
Concluído
2012/12 - 2016/12 New Natural-based (Bio-inspired) supramolecular systems for Biomedical Application.
2012204 (RMB 400,000)
2012204
Investigador responsável
Shanghai Institute of Organic Chemistry, China
 Chinese Academy of Sciences Youth Innovation Promotion Association
Concluído
2015/03 - 2016/08 New Natural-based supramolecular systems for Biomedical Application.
No.011 (CAD $20,400)
Bolseiro de Cientista Convidado
Université de Montréal, Canadá
 Chinese Academy of Sciences Bureau of International Co-operation
Concluído
2011/01 - 2013/12 Synthesis and self-assembly of new cholic acid based functional cationic molecules as carriers for nucleic acid substances delivery
21002116
NO.21002116 (RMB 190,000)
Investigador responsável
Shanghai Institute of Organic Chemistry, China
 National Natural Science Foundation of China
Concluído
2009/12 - 2011/06 Cholesterol-based Controllable cationic gene carriers for nucleic acid substances delivery.
10R21418400 (RMB 80, 000)
Bolseiro de Pós-Doutoramento
Shanghai Institute of Organic Chemistry, China
 Science and Technology Commission of Shanghai Municipality
Concluído
2009/10 - 2011/06 Design and synthesis of novel fluorescent amphiphilic molecules, their interactions with nucleic acids and biological applications.
20090460676
20090460676 (RMB 30, 000)
Bolseiro de Pós-Doutoramento
Shanghai Institute of Organic Chemistry, China
 China Postdoctoral Science Foundation
Concluído

Projeto

Designação Financiadores
2022/06/01 - 2025/05/31 GlycoPolymer-based Smart Nanobiomaterials for Gene-Prodrug Synergistic Delivery
2021.00453.CEECIND
Investigador responsável
Universidade da Madeira Centro de Química da Madeira, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Freitas, Pedro; Maciel, Dina; Jaskowska, Jolanta; Zenczak-Tomera, Kamila; Zhou, Yanbiao; Yin, Guoyin; Sheng, Ruilong. "Facile Synthesis of a Cholesterol–Doxorubicin Conjugate Using Cholesteryl-4-nitrophenolate as an Activated Ester and Biological Property Analysis". Organics 6 1 (2025): 6. https://doi.org/10.3390/org6010006.
    10.3390/org6010006
  2. Niedziejko-Cwiertnia, Paulina; Drabczyk, Anna Karolina; Kulaga, Damian; Podobinska, Patrycja; Bachowski, Wojciech; Zenczak-Tomera, Kamila; Michorczyk, Piotr; Sheng, Ruilong; Jaskowska, Jolanta. "Environmentally Friendly Green O-Alkylation Reaction for Ethenzamide Synthesis". Applied Sciences 15 3 (2025): 1342. https://doi.org/10.3390/app15031342.
    10.3390/app15031342
  3. Wenhao Yu; Dong Zhou; Fangrui Liu; Xu Li; Lan Xiao; Muhammad Rafique; Zhiyong Li; et al. "Conjugation of PDLA onto MgO microspheres: comparison between solution grafting and melt grafting methods". Journal of Materials Chemistry B (2025): https://doi.org/10.1039/D4TB02692F.
    10.1039/D4TB02692F
  4. Zhao Wang; Jiajian Shi; Mengyao Gu; Xiaojuan Zhang; Ruilong Sheng. "A versatile strategy to construct surface functionalized pH/redox dual stimuli-responsive nanogels for targeted drug delivery". Journal of Applied Polymer Science (2024): https://doi.org/10.1002/app.54908.
    10.1002/app.54908
  5. Jinkai Zhang; Yu Zhuang; Ruilong Sheng; Helena Tomás; João Rodrigues; Guangyin Yuan; Xudong Wang; Kaili Lin. "Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics". Materials Horizons (2024): https://doi.org/10.1039/D3MH01260C.
    10.1039/D3MH01260C
  6. Tian, Ye; Wang, Zhiqiang; Xu, Xu; Guo, Yunqi; Ma, Yanni; Lu, Yanqi; Shen, Mingwu; et al. "Natural alkaloids from Dicranostigma leptopodum (Maxim.) Fedde and their G5. NHAc-PBA dendrimer-alkaloid complexes for targeting chemotherapy in breast cancer MCF-7 cells". Natural Product Research (2024): https://publons.com/wos-op/publon/67837302/.
    10.1080/14786419.2024.2335669
  7. Wang, Zhao; Zhao, Fugui; Lv, Yi; Wang, Yujie; Guo, Xinyu; Zhang, Xiaojuan; Lin, Qing; Sheng, Ruilong. "Facile preparation of zwitterionic core-shell nanogels for dual-functional coatings: Combining antifouling and antibacterial features in silicon implant model surface modification". Surfaces and Interfaces (2024): https://publons.com/wos-op/publon/68925473/.
    10.1016/J.SURFIN.2024.104540
  8. Jian Chen; Hui Wang; Li Zhang; Wanying Yan; Sheng, Ruilong. "Facile preparation of PEGylated polyethylenimine polymers as vaccine carriers with reduced cytotoxicity and enhanced Interleukin-2 (IL-2) production". Colloids and Surfaces B: Biointerfaces (2023): https://doi.org/10.1016/j.colsurfb.2023.113520.
    10.1016/j.colsurfb.2023.113520
  9. Xichao Hu; Yingjun Ke; Huan Ye; Beitong Zhu; João Rodrigues; Sheng, Ruilong. "Toward public security monitoring: A perspective of optical molecular probes for phosgene and mustard gas detection". Dyes and Pigments (2023): https://doi.org/10.1016/j.dyepig.2023.111379.
    10.1016/j.dyepig.2023.111379
  10. Yifan Shen; Ruilong Sheng; Ruihua Guo. "Application of Zebrafish as a Model for Anti-Cancer Activity Evaluation and Toxicity Testing of Natural Products". Pharmaceuticals (2023): https://doi.org/10.3390/ph16060827.
    10.3390/ph16060827
  11. Na Li; Xinyu Li; Meidi Deng; Feifei Zhu; Zian Wang; Ruilong Sheng; Wenhui Wu; Ruihua Guo. "Isosteviol derivatives as protein tyrosine Phosphatase-1B inhibitors: Synthesis, biological evaluation and molecular docking". Bioorganic & Medicinal Chemistry (2023): https://doi.org/10.1016/j.bmc.2023.117240.
    10.1016/j.bmc.2023.117240
  12. Sun, Xiaojing; Xing, Lin; Yuan, Jieying; Wang, Enxiao; Ding, Yuxin; Sheng, Ruilong; Wang, Fang; et al. "Synthesis and biological evaluation of novel demethylzeylasteral derivatives as potential anticancer agents". Fitoterapia (2023): https://publons.com/wos-op/publon/62231985/.
    10.1016/J.FITOTE.2023.105504
  13. Huan Ye; Seyoung Koo; Beitong Zhu; Yingjun Ke; Ruilong Sheng; Ting Duan; Lintao Zeng; Jong Seung Kim. "Real-Time Fluorescence Screening Platform for Meat Freshness". Analytical Chemistry (2022): https://doi.org/10.1021/acs.analchem.2c03326.
    10.1021/acs.analchem.2c03326
  14. Zhao Wang; Xinyu Guo; Lingyun Hao; Xiaojuan Zhang; Qing Lin; Sheng, Ruilong. "Charge-Convertible and Reduction-Sensitive Cholesterol-Containing Amphiphilic Copolymers for Improved Doxorubicin Delivery". Materials (2022): https://doi.org/10.3390/ma15186476.
    10.3390/ma15186476
  15. Jinkai Zhang; Cancan Zhao; Ruilong Sheng; Kaili Lin; Xudong Wang; Shilei Zhang. "Construction of a Hierarchical Micro-/Submicro-/Nanostructured 3D-Printed Ti6Al4V Surface Feature to Promote Osteogenesis: Involvement of Sema7A through the ITGB1/FAK/ERK Signaling Pathway". ACS Applied Materials & Interfaces (2022): https://doi.org/10.1021/acsami.2c06454.
    10.1021/acsami.2c06454
  16. Zeyu Fu; Yu Zhuang; Jinjie Cui; Ruilong Sheng; Helena Tomás; João Rodrigues; Bin Zhao; Xudong Wang; Kaili Lin. "Development and challenges of cells- and materials-based tooth regeneration". Engineered Regeneration (2022): https://doi.org/10.1016/j.engreg.2022.04.003.
    10.1016/j.engreg.2022.04.003
  17. Noora Barzkar; Ruilong Sheng; Muhammad Sohail; Saeid Tamadoni Jahromi; Olga Babich; Stanislav Sukhikh; Reza Nahavandi. "Alginate Lyases from Marine Bacteria: An Enzyme Ocean for Sustainable Future". Molecules (2022): https://www.mdpi.com/1420-3049/27/11/3375.
    10.3390/molecules27113375
  18. Zhe Fu; Linjie Zhang; Sijin Hang; Shiyi Wang; Na Li; Xiaojing Sun; Zian Wang; et al. "Synthesis of Coumarin Derivatives: A New Class of Coumarin-Based G Protein-Coupled Receptor Activators and Inhibitors". Polymers (2022): https://www.mdpi.com/2073-4360/14/10/2021.
    10.3390/polym14102021
  19. Zhaoyuan Zhu; Li Zhang; Sheng, Ruilong; Jian Chen. "Microfluidic-Based Cationic Cholesterol Lipid siRNA Delivery Nanosystem: Highly Efficient In Vitro Gene Silencing and the Intracellular Behavior". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/7/3999.
    10.3390/ijms23073999
  20. Lirong Jiang; Huan Ye; Dini Ma; João Rodrigues; Sheng, Ruilong; Douyong Min. "A smartphone-adaptable fluorescent sensing tag for non-contact and visual monitoring of the freshness of fish". The Analyst (2022): https://doi.org/10.1039/D1AN02191E.
    10.1039/D1AN02191E
  21. Yu, Xingge; Wang, Xiuhui; Li, Dejian; Sheng, Ruilong; Qian, Yifeng; Zhu, Rui; Wang, Xudong; Lin, Kaili. "Mechanically reinforced injectable bioactive nanocomposite hydrogels for in-situ bone regeneration". Chemical Engineering Journal (2022): https://publons.com/wos-op/publon/54356786/.
    10.1016/J.CEJ.2021.132799
  22. Zhu, Beitong; Sheng, Ruilong; Chen, Tianhong; Rodrigues, Joao; Song, Qin-Hua; Hu, Xichao; Zeng, Lintao. "Molecular engineered optical probes for chemical warfare agents and their mimics: Advances, challenges and perspectives". Coordination Chemistry Reviews (2022): https://publons.com/wos-op/publon/51996483/.
    10.1016/J.CCR.2022.214527
  23. Hang, Sijin; Chen, Hui; Wu, Wenhui; Wang, Shiyi; Fang, Yiwen; Sheng, Ruilong; Tu, Qidong; Guo, Ruihua. "Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology, Preparation, and Mechanism". Marine Drugs (2022): https://publons.com/wos-op/publon/54356788/.
    10.3390/MD20060405
  24. Hang, Sijin; Wu, Wenhui; Wang, Yinan; Sheng, Ruilong; Fang, Yiwen; Guo, Ruihua. "Daphnetin, a Coumarin in Genus Stellera Chamaejasme Linn: Chemistry, Bioactivity and Therapeutic Potential". Chemistry and Biodiversity (2022): https://publons.com/wos-op/publon/52552135/.
    10.1002/CBDV.202200261
  25. Wang, Zhao; Song, Wenli; Sheng, Ruilong; Guo, Xinyu; Hao, Lingyun; Zhang, Xiaojuan. "Controlled preparation of cholesterol-bearing polycations with pendent l-lysine for efficient gene delivery". International Journal of Polymeric Materials and Polymeric Biomaterials (2022): https://publons.com/wos-op/publon/51553189/.
    10.1080/00914037.2022.2058943
  26. Liu, Yuebin; Sheng, Ruilong; Fan, Junting; Guo, Ruihua. "A Review on Structure-Activity Relationships of Glycyrrhetinic Acid Derivatives with Diverse Bioactivities". Mini-Reviews in Medicinal Chemistry (2022): https://publons.com/wos-op/publon/54356787/.
    10.2174/1389557522666220126093033
  27. Sheng-Lin Pei; Jin Zhang; Wanyun Ge; Chao Liu; Ruilong Sheng; Lintao Zeng; Ling-Hui Pan. "A resorufin-based fluorescence probe for visualizing biogenic amines in cells and zebrafish". RSC Advances (2022): https://doi.org/10.1039/D2RA06482K.
    10.1039/D2RA06482K
  28. Ye, Huan; Ke, Yingjun; Yue, Chenyang; Xie, Peng; Sheng, Ruilong; Zeng, Lintao. "5G smartphone-adaptable fluorescence sensing platform for simultaneous detection of toxic formaldehyde and phosgene in different emission channels". Dyes and Pigments (2022): https://publons.com/wos-op/publon/57428540/.
    10.1016/J.DYEPIG.2022.110782
  29. Sun, Xiaojing; Shen, Binyu; Yu, Hui; Wu, Wenhui; Sheng, Ruilong; Fang, Yiwen; Guo, Ruihua. "Therapeutic potential of demethylzeylasteral, a triterpenoid of the genus Tripterygium wilfordii". Fitoterapia (2022): https://publons.com/wos-op/publon/62232005/.
    10.1016/J.FITOTE.2022.105333
  30. wang zhao; Xinhua Li; Xiaojuan Zhang; Ruilong Sheng; Qing Lin; Wenli Song; Lingyun Hao. "Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery". Nanomaterials (2021): https://www.mdpi.com/2079-4991/11/9/2328.
    10.3390/nano11092328
  31. Yinan Wang; Hui Chen; Ruilong Sheng; Zhe Fu; Junting Fan; Wen Hui Wu; Qidong Tu; Ruihua Guo. "Synthesis and Bioactivities of Marine Pyran-Isoindolone Derivatives as Potential Antithrombotic Agents". Marine Drugs (2021): https://www.mdpi.com/1660-3397/19/4/218.
    10.3390/md19040218
  32. Wang. Zhao; Olim, Filipe; Sun, Jingjing; Neves, Ana Rute; Mendes, Fátima; Tomás, Helena; Sheng, Ruilong. "Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy". Medicine Research 5 2000231 (2021): http://www.medicineresearch.org/EN/10.21127/yaoyimr20200023.
  33. Olim, F.; Neves, A.R.; Vieira, M.; Tomás, H.; Sheng, Ruilong. "Self-Assembly of Cholesterol-Doxorubicin and TPGS into Prodrug-Based Nanoparticles with Enhanced Cellular Uptake and Lysosome-Dependent Pathway in Breast Cancer Cells". European Journal of Lipid Science and Technology 123 5 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103680759&partnerID=MN8TOARS.
    10.1002/ejlt.202000337
  34. Zeng, Y.; Xiang, Y.; Sheng, R.; Tomás, H.; Rodrigues, J.; Gu, Z.; Zhang, H.; Gong, Q.; Luo, K.. "Polysaccharide-based nanomedicines for cancer immunotherapy: A review". Bioactive Materials 6 10 (2021): 3358-3382. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102635239&partnerID=MN8TOARS.
    10.1016/j.bioactmat.2021.03.008
  35. Wang, Z.; Sun, J.; Li, M.; Luo, T.; Shen, Y.; Cao, A.; Sheng, Ruilong. Autor correspondente: Sheng, Ruilong. "Natural steroid-based cationic copolymers cholesterol/diosgenin-r-PDMAEMAs and their pDNA nanoplexes: impact of steroid structures and hydrophobic/hydrophilic ratios on pDNA delivery". RSC Advances 11 32 (2021): 19450-19460. http://www.scopus.com/inward/record.url?eid=2-s2.0-85107782615&partnerID=MN8TOARS.
    10.1039/d1ra00223f
  36. Lu S; Wang J; Sheng R; Fang Y; Guo R. "Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019.". Chemistry & biodiversity (2020): http://europepmc.org/abstract/med/33206470.
    10.1002/cbdv.202000562
  37. Wang Y; Wang J; Fu Z; Sheng R; Wu W; Fan J; Guo R. "Syntheses and evaluation of daphnetin derivatives as novel G protein-coupled receptor inhibitors and activators.". Bioorganic chemistry (2020): http://europepmc.org/abstract/med/33142412.
    10.1016/j.bioorg.2020.104342
  38. Zhu B; Wu X; Rodrigues J; Hu X; Sheng, Ruilong; Bao GM. "A dual-analytes responsive fluorescent probe for discriminative detection of ClO- and N2H4 in living cells.". Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2020): http://europepmc.org/abstract/med/32987268.
    10.1016/j.saa.2020.118953
  39. Zhang X; Wu Y; Li Z; Wang W; Pan D; Gu Z; Sheng R; et al. "Glycodendron/pyropheophorbide-a (Ppa)-functionalized hyaluronic acid as a nanosystem for tumor photodynamic therapy.". Carbohydrate polymers (2020): http://europepmc.org/abstract/med/32829865.
    10.1016/j.carbpol.2020.116749
  40. Zhao Wang; Xiaojuan Zhang; Qing Lin; Jingjing Sun; Santanu Bhattachaya; Guosong Chen; Sheng, Ruilong. "Functional Glycopolypeptides: Synthesis and Biomedical Applications". Advances in Polymer Technology (2020): https://doi.org/10.1155/2020/6052078.
    10.1155/2020/6052078
  41. Zeng L; Chen T; Chen BQ; Yuan HQ; Sheng, Ruilong; Bao GM. "A distinctive mitochondrion-targeting, in situ-activatable near-infrared fluorescent probe for visualizing sulfur dioxide derivatives and their fluctuations in vivo.". Journal of materials chemistry. B (2020): http://europepmc.org/abstract/med/32048683.
    10.1039/c9tb02593f
  42. An F; Yang Z; Zheng M; Mei T; Deng G; Guo P; Li Y; Sheng R. "Rationally assembled albumin/indocyanine green nanocomplex for enhanced tumor imaging to guide photothermal therapy.". Journal of nanobiotechnology (2020): http://europepmc.org/abstract/med/32183838.
    10.1186/s12951-020-00603-8
  43. Wang J; Lu S; Sheng R; Fan J; Wu W; Guo R. "Structure-Activity Relationships of Natural and Synthetic Indole-Derived Scaffolds as a-Glucosidase Inhibitors: A Mini-Review.". Mini reviews in medicinal chemistry (2020): http://europepmc.org/abstract/med/32560604.
    10.2174/1389557520666200619121003
  44. Filipe Olim; Ana Rute Neves; Zhao Wang; Jingjing Sun; Helena Tomás; and Ruilong Sheng. "Prodrug Systems (I): Lipid-Based Doxorubicin Prodrugs and Their Nanodelivery Systems". Medicine Research 4 1-2 (2020): 200013-200013. https://doi.org/10.21127%2Fyaoyimr20200013.
    10.21127/yaoyimr20200013
  45. Wang, Jiangming; Su, Siyuan; Zhang, Shangzhe; Zhai, Shiyang; Sheng, Ruilong; Wu, Wenhui; Guo, Ruihua. "Structure-activity relationship and synthetic methodologies of a-santonin derivatives with diverse bioactivities: A mini-review". European Journal of Medicinal Chemistry 175 (2019): 215-233. http://dx.doi.org/10.1016/j.ejmech.2019.04.066.
    10.1016/j.ejmech.2019.04.066
  46. Wu, Juanjuan; Su, Dongdong; Qin, Caiqin; Li, Wei; Rodrigues, João; Sheng, Ruilong; Zeng, Lintao. "A fast responsive chromogenic and near-infrared fluorescence lighting-up probe for visual detection of toxic thiophenol in environmental water and living cells". Talanta 201 (2019): 111-118. http://dx.doi.org/10.1016/j.talanta.2019.03.113.
    10.1016/j.talanta.2019.03.113
  47. Sun, J.; Wang, Z.; Cao, A.; Sheng, R.. "Synthesis of crosslinkable diblock terpolymers PDPA-b-P(NMS-co-OEG) and preparation of shell-crosslinked pH/redox-dual responsive micelles as smart nanomaterials". RSC Advances 9 59 (2019): 34535-34546. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074501623&partnerID=MN8TOARS.
    10.1039/c9ra05082e
  48. Wu, X.; Zeng, L.; Chen, B.-Q.; Zhang, M.; Rodrigues, J.; Sheng, R.; Bao, G.-M.. "A selective cascade reaction-based probe for colorimetric and ratiometric fluorescence detection of benzoyl peroxide in food and living cells". Journal of Materials Chemistry B 7 38 (2019): 5775-5781. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072849089&partnerID=MN8TOARS.
    10.1039/c9tb00889f
  49. Wang, Zhao; Hao, Lingyun; Zhang, Xiaojuan; Sheng, Ruilong. "Advances of “Click” Reaction Approach in Glycopolypeptide Synthesis". Chinese Journal of Organic Chemistry 39 9 (2019): 2379. http://dx.doi.org/10.6023/cjoc201903038.
    10.6023/cjoc201903038
  50. Jiang, Lirong; Wu, Juanjuan; Min, Douyong; Rodrigues, João; Sheng, Ruilong. "Chemical sensors towards environmental toxic molecule monitoring: fluorescent probes for detection of thiophenol". General Chemistry (2019): http://hdl.handle.net/10400.13/2879.
    10.21127/yaoyigc20190027
  51. Wang, Zhao; Neves, Ana Rute; Olim, Filipe; Tomás, Helena; Tang, Shi; Sheng, Ruilong. "Green polymers toward nanobiotechnology(I): synthesis of glycopolypeptides and their analogues". General Chemistry (2019): 20190010. http://hdl.handle.net/10400.13/2847.
    10.21127/yaoyigc20190010
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  113. Sheng, R.; Wang, P.; Liu, W.; Wu, X.; Wu, S.. "A new colorimetric chemosensor for Hg2+ based on coumarin azine derivative". Sensors and Actuators, B: Chemical 128 2 (2008): 507-511. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549053644&partnerID=MN8TOARS.
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  114. Guo, H.-M.; Liu, W.-M.; Sheng, R.-L.; Wang, F.; Wang, P.-F.; Wu, S.-K.. "New fluoride colorimetric chemosensor based on coumarin". Imaging Science and Photochemistry 26 6 (2008): 468-473. http://www.scopus.com/inward/record.url?eid=2-s2.0-57849161623&partnerID=MN8TOARS.
    Publicado
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  116. Wang, W.-W.; Wang, N.-X.; Xing, Y.-L.; Sheng, R.L.; Zhao, J.. "Synthesis of N3, N4-bis (2,4-dinitrobenzofuroxan)- N3, N4-dinitro-1,2,5-oxadiazole-3,4-diamine". Heterocyclic Communications 12 1 (2006): 43-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646106329&partnerID=MN8TOARS.
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Capítulo de livro
  1. Sheng, Ruilong. "Steroid-Based Supramolecular Systems and their Biomedical Applications: Biomolecular Recognition and Transportation". In Chemistry and Biological Activity of Steroids. Portugal: IntechOpen, 2020.
    Publicado • 10.5772/intechopen.86752

Propriedade Intelectual

Patente
  1. Yuhong Xu; Hui Wang; Jian Chen; Sheng, Ruilong; Amin Cao. 2016. "Polyethylene glycol modified polyethyleneimine and use of polyethylene glycol modified polyethyl-eneimine as antigen protein vector. (CN103627005B)". China.
  2. Cao, Amin; Li, Hui; Sheng, Ruilong; Luo, Ting; Sun, Jingjing. 2016. "Polymethacrylamide cationic polymer cooperatively modified by side groups natural arginine and lactobionic acid, preparation method and application (CN104086685B)". China.
    Concedida/Emitida
  3. Sheng, Ruilong; Cao, Amin; Wang, Zhao. 2015. "Synthetic cationic lipid derived from natural diosgenin as well as synthesis method and application of synthetic cationic lipid (CN104844686A)". China.
  4. Cao, Amin; Sheng, Ruilong; Wang, Zhao; Li Mingrui. 2014. "Synthetic cationic lipid with zoosterol and natural arginine structural fragment, synthesis method and application. (CN103772469A)". China.
    Permitida
  5. Cao, Amin; Sun, Jingjing; Luo, Ting; Sheng, Ruilong. 2014. "Cationic functional polymers with natural amino acid as side group, preparation method and application of polymer (CN103665222A)". China.
    Permitida
  6. Sheng, Ruilong; Cao, Amin; Wang, Zhao; Sun, Jingjing. 2014. "Polyethyleneimine function cation polymer derived from natural cholesterol, synthesis method and uses thereof. (CN103570942A)". China.
    Retirada
  7. Cao, Amin; Li, Hui; Luo, Ting; Sheng, Ruilong. 2013. "Poly(methyl)acrylamide cationic polymer modified by natural arginine on side chain, preparation method and application. (CN103360531A)". China.
  8. Cao, Amin; Sheng, Ruilong; Chen Jian; Xu, Yuhong; Wang, Zhao; Tian, Xiaojing. 2013. "Organic functional molecule containing natural cholesterol and lysine lipid cations, liposome thereof, as well as preparation method and application for lipidosome (CN103214541A)". China.
  9. Wang, Pengfei; Sheng, Ruilong; Zhang, Hongyan; Liu, Weimin. 2012. "Fluorescent probe for selectively detecting zinc ions in cells, synthesizing method thereof and application thereof (CN101613344B)". China.
    Concedida/Emitida
  10. Sheng, Ruilong; Wang, Pengfei; Wang, Fang. 2011. "Fluorescent probe for detecting biological sulfhydryl compounds, its synthetic method and application (CN102234261B)". China.
    Concedida/Emitida
  11. Sheng, Ruilong; Cao, Amin; Sun, Jingjing; Li, Hui. 2011. "Cholesterol-structure-fragment-containing biocompatible synthesis liposomes as well as preparation method and application (CN102161688A)". China.
    Concedida/Emitida
  12. Cao, Amin; Sheng, Ruilong. 2010. "Organic functional compound having disulfide chemical bond and steroids skeleton, preparation method thereof and use thereof (CN101870719B)". China.
    Concedida/Emitida
  13. Wang, Pengfei; Sheng, Ruilong; Zhang, Hongyan; Zhuang, Xiaoqing; Dai, Qing. 2010. "Long-wavelength fluorescent probe for detecting zinc ions in water phase, synthesis method thereof and use thereof (CN101624520B)". China.
  14. Wang, Pengfei; Sheng, Ruilong; Zhang, Hongyan; Wu, Jiasheng. 2009. "Renewable fluorescent probe for selectively detecting bioactive sulfydryl compound in cell and synthetic method and application thereof (CN101597297B)". China.
    Concedida/Emitida
  15. PENGFEI WANG; RUILONG SHENG; WEIMIN LIU; HONGYAN ZHANG; Sheng, Ruilong. 2008. "Fluorescent probe for detecting glutathione reductase and bioactive sulfhydryl compound as well as synthesis method and application thereof". China.
    Concedida/Emitida
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/11/28 Natural steroid lipid-based gene/drug delivery nanosystems: A decade of exploration MAD-Nano24: Madeira International Conference on Emerging Trends and Future of Nanomaterials for Human Health.
Centro de Quimica da Madeira, Universidade da Madeira (Funchal, Portugal)
2024/10/03 Green biomaterials (V): Natural steroid-based nanobiomaterials for DOX autophagy inhibitor synergistic drug delivery, and in-silico QSAR model for biomolecule optimization 11th CQM Annual Meeting
Centro de Quimica da Madeira, Universidade da Madeira (Funchal, Portugal)
2024/03/05 Green Organic Chemistry (I): Click Chemistry in the Synthesis of Bioactive Molecules, Functional Glycopolymers and Biomaterials Seminars on green organic catalysis and phase transfer catalysis (March 05-06)
Centro de Quimica da Madeira (Funchal, Portugal)
2023/06/01 Green Biomaterials (IV): Natural-based Steroid Copolymers with pH/redox Dual Stimuli-Responsive Properties towards Cancer Chemotherapy 10th CQM Annual Meeting
Centro de Quimica da Madeira (Funchal, Portugal)
2022/09/29 Green Biomaterials (III): Natural Steroid-based nanobiomaterials for gene/drug delivery 9th CQM Annual Meeting
Centro de Quimica da Madeira (Funchal, Portugal)
2020/09/21 pH/redox Dual Stimuli-responsive Nanomaterials for Controllable Drug Release. 7th CQM Annual Meeting
University of Madeira, Centro de Quimica da Madeira/Madeira Chemistry Research Center (Funchal, Madeira, Portugal)
2019/04 Green Nanobiomaterials (II), Natural-based amphiphilic glycopolymers as nanomaterials for biomedical Application 6th CQM Annual Meeting
University of Madeira, Madeira Chemistry Research Center (Funchal, Portugal)
2018/11 Green Nanobiomaterials (I), Natural(l-)-lysine-based Functional Macromolecules/ Polymers for Gene Delivery Application. MAD-Nano18, Madeira International Conference on Emerging Trends and Future of Nanomaterials for Human Health.
University of Madeira (Funchal, Portugal)
2018/02/01 Natural-based amphiphilic molecules, their nano-assemblies and biomedical applications. 5th CQM Annual Meeting
University of Madeira, Madeira Chemistry Research Center (Funchal, Portugal)
2017/03/28 Steroid-based Cationic lipids for gene delivery applications CAS-Canada young visiting scientist presentation
Department of Bioengineering, McGill University (Montreal, Canadá)
2016/09/23 Study on the structure-property relationships of steroid-based lipid gene carriers CAS-Youth Innovation Promotion Association (YIPA)-2019 Annual Meeting
CAS-Youth Innovation Promotion Association (YIPA), Chinese Academy of Sciences (Suzhou, China)
2015/03/16 Steroid-based Cationic lipids for gene delivery applications CAS-Canada visiting scientists presentation
Department of Chemistry, Université de Montréal (Montreal, Canadá)
2013/07/12 Cholesterol-based cationic lipids for gene delivery CSIRO-invited visiting scientist presentation
CSIRO Materials Science and Engineering (Melbourne, Austrália)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2024/11/28 - Atual Co-organized a session of MADnano24 International Conference (Nov. 28. 2024, afternoon session 4, 16:25-18:35. Co-chairs: Dr. Urszula Stachewicz, Dr. Ruilong Sheng) (2024/11/28 - 2024/11/30)
Conferência (Coorganizador)
 Universidade da Madeira, Portugal
2024/03/05 - 2024/03/06 Organized ''Seminars on Green Organic Catalysis and Phase Transfer Catalysis'' (March 05-06, 14:00-17:00, Joint seminar of researchers from Cracow University of Technology, Poland and CQM-UMa , Portugal) (2024/03/05 - 2024/03/06)
Seminário (Membro da Comissão Organizadora)
 Universidade da Madeira Centro de Química da Madeira, Portugal
2022/09/29 - 2022/09/29 Co-Organize a session of 9th CQM Annual Meeting (Sep. 29. 2022, afternoon session, 14:00-15:50, Chair: Dr. Ruilong Sheng) (2022/09/29 - 2022/09/29)
Conferência (Coorganizador)
 Universidade da Madeira Centro de Química da Madeira, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019/11/28 - 2019/11/29 Chemistry is Fun 2019 (A Química é Divertida 2019), CO2 emission-fixation and Geochemistry Effect, Experiment presentation
Exposição
 Experiment presentation
Universidade da Madeira Centro de Química da Madeira, Portugal
2018/11/21 - 2018/11/23 Chemistry is Fun 2018 (A Química é Divertida 2018), Reversible oxidation-reduction Chemical reaction, Experiment presentation
Exposição
 Experiment presentation
Universidade da Madeira Centro de Química da Madeira, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019/01 - Atual General Chemistry (2414-3421) Yaoyi International Publishing
2019/01 - Atual Medicine Research (2521-8743) Yaoyi International Publishing
2022/09 - 2023/04 Nanomaterials. Special Issue: Natural-Based Sustainable Nanobiomaterials for Drug Delivery Applications (2079-4991) MDPI
2022/06 - 2023/01 Frontiers in Bioengineering and Biotechnology. Special Issue: Novel interdisciplinary approaches for effective cancer therapy (2296-4185) Frontiers
2021/10/19 - 2022/10/19 Frontiers in Oncology. Special Issue: Optical Molecular Diagnosis and Photodynamic Therapy for Precision Diagnosis and Treatment of Tumors (2234-943X) Frontiers
2022/01 - 2022/10 Frontiers in Chemistry. Special Issue: Functionalized Organic Fluorescent Materials for Biosensing and Bioimaging - Volume II (2296-2646) Frontiers
2020/01 - 2020/08 Frontiers in Chemistry. Special Issue: Functionalized Organic Fluorescent Materials for Biosensing and Bioimaging - Volume I (2296-2646) Frontiers
2019/05 - 2020/01 Advances in Polymer Technology (1098-2329) Hindawi Limited

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2012 - 2015 Evaluated 2 research grant proposals for National Natural Science Foundation of China (NSFC)
Avaliador
 Shanghai Institute of Organic Chemistry, China National Natural Science Foundation of China

Membro de associação

Nome da associação Tipo de participação
2017/02 - Atual American Chemical Society (ACS), USA American Chemical Society member (NO. ACS 31131681)
2012/01 - Atual Youth Innovation Promotion Association (YIPA), Chinese Academy of Sciences, China Life-long member of Youth Innovation Promotion Association (YIPA) (NO. 2012204)
2008/07 - Atual Chinese Chemical Society (CCS), China Chinese Chemical Society (CCS) member, organic and biochemistry division (NO S060015689M)

Tutoria

Tópico Nome do aluno
2024/08 - 2025/01 Polymer-degradation Kinetics Modeling study on the PDLA-MgO hybrid Nanomaterials Wenhao Yu (Master student)
2024/03 - 2024/05 Synthesis of natural lipid-doxorubicin conjugates for chemotherapeutic drug delivery Pedro Freitas (Undergraduate/Bachelor student)
2021/09 - 2022/09 pH/redox-dual Responsive Amphiphilic Copolymers for anti-tumor Drug Delivery Xinyu Guo (master student)
2020/09 - 2021/09 Lipid-Dox Prodrug-based Nanomaterials for Combinational Tumor Chemotherapy. Fatima Mendes (master student)
2020/01 - 2021/01 Fluorescent Probes for Phosgene and organophosphorus agents detection, Design Strategies and Sensing Mechanisms study. Lirong Jiang (PhD student)
2018/01 - 2020/08 Self-assembly of Chol-Dox and TPGS into Prodrug-based Nanomaterials for Combinational Tumor Chemotherapy. Filipe Olim (PhD student)
2017/01 - 2020 Selective Cascade Reaction-Based Probe for Colorimetric and Ratiometric Fluorescence Fast Detection of Benzoyl Peroxide in Food and Living Cells. Xiaoli Wu (master student)
2018/03 - 2019/07 Synthesis and Characterization of Molecularly Precise Lauric Acid-Dendrimer Conjugates for Gene/Drug Delivery. Helena Cha-Cha (master student)
2016/09 - 2018/08 Colorimetric and ratiometric chemosensor for visual detection of gaseous phosgene based on anthracene carboxyimide membrane. Qiao Hu (master student)
2016/09 - 2017/12 Multi-color anthracene carboxyimides: synthesis, spectroscopic properties, solvatochromic fluorescence and bioimaging application. Junchao Xu (master student)
2015/03 - 2017/03 Visible-light-induced cascade cyclization for the synthesis of natural heterocyclic product analogues. Yuan Li (master student)
2011/01 - 2017/01 Morphology-variable aggregates prepared from cholesterol-containing amphiphilic glycopolymers: their protein recognition/adsorption and drug delivery applications. Zhao Wang (Ph.D. student)
2012/09 - 2016/12 Endocytosis pathway analysis of (l)-Arginine/(l)-Histidine co-modified cationic gene carriers. Hui Li (PhD student)
2011/07 - 2016/07 Hydrophobic lipid chain modified polymers for efficient antigen delivery towards immunochemotherapy. Hui Wang (master student)
2012/03 - 2016/03 Using AIBN and beyond to synthesis natural oxindoles via Cu-catalyzed free radical reaction Dong Zhou (master student)
2014/01 - 2015/12 Assembly of plasmid DNA with fluorescent cationic amphiphiles into nanoparticles and their visible intracellular localization Feifei An (Postdoc researcher)
2013/01 - 2015/12 Quantitative and highly selective sensing of sodium houttuyfonate via Aggregation-Induced Emission(AIE). Feifei Yu (master student)
2012/01 - 2014/07 Synthesis of diblock/statistical cationic glycopolymers for gene delivery application and intracellular behaviors. Jingjing Sun (PhD student)
2013/03 - 2014/03 Rhodamine-pathalic diamide derivative for colorimetric and fluorescent "turn-on" detection of Cr3+. Wen Han (master student)
2011/03 - 2013/03 Terminal modification on mPEG-Dendritic poly-(l-)-lysine cationic diblock copolymer for efficient gene delivery. Kejia Xia (master student)
2010/03 - 2013/03 Colorimetric and highly selective fluorescence "turn-on" detection of Cr3+ by using a simple Schiff-base sensor. Huimin Xue (master student)
2009/03 - 2011/03 Rhodamine-based derivatives for Cu2+ sensing and its test strips. Weiling Gao (master student)
Distinções

Prémio

2011 Outstanding Postdoctoral Researcher (2011) in Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
University of the Chinese Academy of Sciences, China
2007 Outstanding Graduate Student (2007) in Technical Institute of Physics and Chemistry, Chinese Academy of Sciences
University of the Chinese Academy of Sciences, China

Título

2012 Life-Long honorary member of Youth Innovation Promotion Association (YIPA), Chinese Academy of Sciences
University of the Chinese Academy of Sciences, China