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Carlos MGA Fontes, was born in 9 Decembre 1968 in Lisbon, Portugal. Carlos Fontes received his DScAgr degree in 1991 from the Technical University of Lisbon. Working at Prof. Harry J. Gilbert laboratory, he was awarded the MSc (1992) PhD (1996) degrees, by the University of Newcastle upon Tyne, United Kingdom. After a Pos-Doc at Prof. Luís Ferreira group (University of Lisbon), he become professor at the Faculty of Veterinary Medicine (FMV) at the University of Lisbon, where he developed cutting edge research in structural and molecular biology of plant cell wall degrading protein complexes (also termed cellulosomes), including the study of structure and function relationships in different Carbohydrate Active enZymes (CAZymes) and Carbohydrate Binding Modules (CBMs). He became Full Professor in 2015 and left the University in September 2021 to become the Chief Scientific Officer of NZYTech genes & enzymes (www.nzytech.com), the company he founded in 2008. NZYTech explores the commercial applications related with the use of recombinant enzymes and molecular kits, in particular in the life science and molecular diagnostic fields. Carlos Fontes has supervised 17 PhD students and is co-author of more than 200 papers published in international refereed journals. Relevant publications: 1. Ana L. Carvalho, Fernando M.V. Dias, José A.M. Prates, Tibor Nagy, Harry J. Gilbert, Gideon J. Davies, Luís M.A. Ferreira, Maria J. Romao & Carlos M.G.A. Fontes (2003) Cellulosome assembly revealed by the crystal structure of the cohesin-dockerin complex. Procedings of the National Academy of Sciences United States of America 100, 13809-13814. 2. Ana L. Carvalho, Fernando M.V. Dias, Tibor Nagy, José A.M. Prates, Mark R. Proctor, Nicola Smith, Edward A. Bayer, Gideon J. Davies, Luís M.A. Ferreira, Maria João Romão, Carlos M.G.A. Fontes e Harry J. Gilbert & (2007). Evidence for a dual binding mode of dockerin modules to cohesins. Procedings of the National Academy of Sciences United States of America 104, 3089-3094. 3. Cedric Montanier, Alicia L. vanBueren, Claire Dumon, James E. Flint, Marcia A. Correia, Jose A.M. Prates, Susan Firbank, Richard J. Lewis, Gilles G. Grondin, Mariana G. Ghinet, Tracey M. Gloster, Cecile Herve, Paul Knox, Brian G. Talbot, Johan P. Turkenburg, Janne Kerovuo, Ryszard Brzezibski, Carlos M.G.A. Fontes, Gideon J. Davies, Alisdair B. Boraston & Harry J. Gilbert (2009). Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function. Procedings of the National Academy of Sciences United States of America 106, 3065-3070. 4. Carlos M.G.A. Fontes & Harry J. Gilbert (2010). Cellulosomes: highly efficient nanomachines designed to deconstruct plant cell wall complex carbohydrates. Annual Reviews in Bichemistry 79, 655-81. 5. Brás JL, Cartmell A, Carvalho AL, Verzé G, Bayer EA, Vazana Y, Correia MA, Prates JA, Ratnaparkhe S, Boraston AB, Romão MJ, Fontes CMGA & Gilbert HJ (2011). Structural insights into a unique cellulase fold and mechanism of cellulose hydrolysis. Procedings of the National Academy of Sciences United States of America 108, 5237-5242. 6. Luís AS, Venditto I, Prates JA, Ferrieira LM, Temple MJ, Rogowski A, Baslé A, Xue J, Knox JP, Najmudin S, Fontes CM & Gilbert HJ (2013). Understanding how non-catalytic carbohydrate binding modules can display specificity for xyloglucan. The Journal of Biological Chemistry 288, 4799-809. 7. Venditto I, Luis AS, Rydahl M, Schückel J, Fernandes VO, Vidal-Melgosa S, Bule P, Goyal A, Pires VM, Dourado CG, Ferreira LM, Coutinho PM, Henrissat B, Knox JP, Baslé A, Najmudin S, Gilbert HJ, Willats WG, Fontes CMGA (2016). Proceedings of the National Academy of Sciences USA 113, 7136-7141.
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Identificação

Identificação pessoal

Nome completo
Carlos MGA Fontes

Nomes de citação

  • Carlos MGA Fontes
  • Fontes, CM
  • Fontes, CMGA

Identificadores de autor

Ciência ID
C01A-FCB3-7F99
ORCID iD
0000-0002-1219-9753

Endereços de correio eletrónico

  • cafontes@fmv.ulisboa.pt (Profissional)
  • carlos.fontes@nzytech.com (Profissional)

Telefones

Fax
  • 213643514 (Profissional)

Moradas

  • NZYTech genes & enzymes, Estrada do Paço do Lumiar, Campus do Lumiar, Edifício E – 1º andar, 1649-038, Lisboa, Lisboa, Portugal (Profissional)

Websites

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/12/09 - 2021/08/31 Professor Catedrático (Docente Universitário) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/09/01 - Atual Diretor Científico NZYTech Lda, Portugal
Projetos

Bolsa

Designação Financiadores
2016/01 - 2018/12 Molecular determinants of bacterial cellulosome diversity in different ecological niches
grant.Provided by PTCRIS: 144587
 Fundação para a Ciência e a Tecnologia
2013/07 - 2016/06 Modern Structural Biology: Resources for the advancement of in-house X-ray Crystallography
grant.Provided by PTCRIS: 125363
 Fundação para a Ciência e a Tecnologia
2013/07 - 2014/12 Development of cohesin- microarrays for determining cohesin-dockerin specificities of novel cellulolytic species
grant.Provided by PTCRIS: 126085
 Fundação para a Ciência e a Tecnologia
2013/06 - 2014/11 An Innovative Recombinant Hit-Maximization Strategy to Unravel the Structure of Cohesin-Dockerin Complexes of Bacteroides cellulosolvens and Acetivibrio cellulolyticus
grant.Provided by PTCRIS: 129521
 Fundação para a Ciência e a Tecnologia
2011/03 - 2014/08 A carbohydrate microarray platform for discovery of ligands in polysaccharides recognised by microbial carbohydrate-binding modules.
grant.Provided by PTCRIS: 112537
 Fundação para a Ciência e a Tecnologia
2010/03 - 2013/11 Improving fat partioning and nutritional quality in pigs: developing feeding strategies and providing insights into genetic and metabolic mechanisms
grant.Provided by PTCRIS: 99210
 Fundação para a Ciência e a Tecnologia
2010/01 - 2013/10 Molecular mechanisms affecting the efficacy of feed enzymes: endogenous beta-glucanases, protein-inhibitors and mini-cellulosomes
grant.Provided by PTCRIS: 103942
 Fundação para a Ciência e a Tecnologia
2010/03 - 2013/08 Prion gene complex: insights on ram fertility
grant.Provided by PTCRIS: 98607
 Fundação para a Ciência e a Tecnologia
2010/01 - 2013/06 The Cellulosome assembly: structure, function and specificity of new cellulases and supramolecular complexes
grant.Provided by PTCRIS: 100359
 Fundação para a Ciência e a Tecnologia
2010/01 - 2013/06 Structure and function of novel Glycoside Hydrolases and Carbohydrate-Binding Modules of Clostridium thermocellum cellulosome
grant.Provided by PTCRIS: 103980
 Fundação para a Ciência e a Tecnologia
2009/01 - 2011/12 Structure and function of novel carbohydrate-binding modules and cohesin-dockerin protein complexes from Clostridium thermocellum
grant.Provided by PTCRIS: 69732
 Fundação para a Ciência e a Tecnologia
2007/10 - 2011/01 An integrated study of lipid composition and its genetic regulation in bovine meats with Protected Designation of Origin (PDO)
grant.Provided by PTCRIS: 66114
 Fundação para a Ciência e a Tecnologia
2007/10 - 2010/12 Rational utilization of cellulases and hemicellulases for improving meat quality and the nutritive value of cereal-based diets for poultry
grant.Provided by PTCRIS: 69329
 Fundação para a Ciência e a Tecnologia
2007/01 - 2010/01 Doppel gene polymorphisms characterization according to scrapie susceptibility genotypes in Portuguese sheep breeds and their impact on male fertility.
grant.Provided by PTCRIS: 82560
 Fundação para a Ciência e a Tecnologia
2007/01 - 2009/04 Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes
grant.Provided by PTCRIS: 82210
 Fundação para a Ciência e a Tecnologia
2007/01 - 2009/01 Using recombinant enzymes for improving broiler performance and meat quality
grant.Provided by PTCRIS: 82499
 Fundação para a Ciência e a Tecnologia
2005/06 - 2008/05 Doppel gene polymorphisms characterization according to scrapie susceptibility genotypes in Portuguese sheep breeds and their impact on male fertility.
grant.Provided by PTCRIS: 57148
 Fundação para a Ciência e a Tecnologia
2005/07 - 2007/12 Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes
grant.Provided by PTCRIS: 59118
 Fundação para a Ciência e a Tecnologia
2005/07 - 2007/12 Using recombinant enzymes for improving broiler performance and meat quality
grant.Provided by PTCRIS: 61162
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Coelho, Diogo; Alfaia, Cristina M.; Lopes, Paula A.; Pestana, José M.; Costa, Mónica M.; Pinto, Rui M.A.; Almeida, João M.; et al. "Impact of Chlorella vulgaris as feed ingredient and carbohydrases on the health status and hepatic lipid metabolism of finishing pigs". Research in Veterinary Science 144 (2022): 44-53. http://dx.doi.org/10.1016/j.rvsc.2022.01.008.
    10.1016/j.rvsc.2022.01.008
  2. Costa, Mónica M.; Pio, Luís B.; Bule, Pedro; Cardoso, Vânia A.; Duarte, Marlene; Alfaia, Cristina M.; Coelho, Diogo F.; et al. "Recalcitrant cell wall of Ulva lactuca seaweed is degraded by a single ulvan lyase from family 25 of polysaccharide lyases". Animal Nutrition (2022): http://dx.doi.org/10.1016/j.aninu.2022.01.004.
    10.1016/j.aninu.2022.01.004
  3. Correia, Viviana G.; Trovão, Filipa; Pinheiro, Benedita A.; Brás, Joana L. A.; Silva, Lisete M.; Nunes, Cláudia; Coimbra, Manuel A.; et al. "Mapping Molecular Recognition of ß1,3-1,4-Glucans by a Surface Glycan-Binding Protein from the Human Gut Symbiont Bacteroides ovatus". Microbiology Spectrum 9 3 (2021): http://dx.doi.org/10.1128/spectrum.01826-21.
    10.1128/spectrum.01826-21
  4. Mondal, Sunetra; Thakur, Abhijeet; Fontes, Carlos M. G. A.; Goyal, Arun. "A trimodular family 16 glycoside hydrolase from the cellulosome of Ruminococcus flavefaciens displays highly specific licheninase (EC 3.2.1.73) activity". Microbiology 167 7 (2021): http://dx.doi.org/10.1099/mic.0.001055.
    10.1099/mic.0.001055
  5. Costa, Mónica; Pio, Luís; Bule, Pedro; Cardoso, Vânia; Alfaia, Cristina M.; Coelho, Diogo; Brás, Joana; Fontes, Carlos M. G. A.; Prates, José A. M.. "An individual alginate lyase is effective in the disruption of Laminaria digitata recalcitrant cell wall". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-89278-1.
    10.1038/s41598-021-89278-1
  6. Ahmed, Jebin; Kumar, Krishan; Sharma, Kedar; Fontes, Carlos M. G. A.; Goyal, Arun. "Computational and SAXS-based structure insights of pectin acetyl esterase (CtPae12B) of family 12 carbohydrate esterase from Clostridium thermocellum ATCC 27405". Journal of Biomolecular Structure and Dynamics (2021): 1-18. http://dx.doi.org/10.1080/07391102.2021.1911858.
    10.1080/07391102.2021.1911858
  7. Alfaia, C.M.; Pestana, J.M.; Rodrigues, M.; Coelho, D.; Aires, M.J.; Ribeiro, D.M.; Major, V.T.; et al. "Influence of dietary Chlorella vulgaris and carbohydrate-active enzymes on growth performance, meat quality and lipid composition of broiler chickens". Poultry Science 100 2 (2021): 926-937. http://dx.doi.org/10.1016/j.psj.2020.11.034.
    10.1016/j.psj.2020.11.034
  8. Duarte, Marlene; Viegas, Aldino; Alves, Victor D.; Prates, José A.M.; Ferreira, Luís M.A.; Najmudin, Shabir; Cabrita, Eurico J.; et al. "A dual cohesin–dockerin complex binding mode in Bacteroides cellulosolvens contributes to the size and complexity of its cellulosome". Journal of Biological Chemistry 296 (2021): 100552. http://dx.doi.org/10.1016/j.jbc.2021.100552.
    10.1016/j.jbc.2021.100552
  9. Coelho, Diogo; Pestana, José; Almeida, João M.; Alfaia, Cristina M.; Fontes, Carlos M. G. A.; Moreira, Olga; Prates, José A. M.. "A High Dietary Incorporation Level of Chlorella vulgaris Improves the Nutritional Value of Pork Fat without Impairing the Performance of Finishing Pigs". Animals 10 12 (2020): 2384. http://dx.doi.org/10.3390/ani10122384.
    10.3390/ani10122384
  10. Reynaud, Steve; Ciolek, Justyna; Degueldre, Michel; Saez, Natalie J.; Sequeira, Ana Filipa; Duhoo, Yoan; Brás, Joana L. A.; et al. "A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists". Journal of Medicinal Chemistry 63 15 (2020): 8250-8264. http://dx.doi.org/10.1021/acs.jmedchem.0c00485.
    10.1021/acs.jmedchem.0c00485
  11. Pestana, J.M.; Puerta, B.; Santos, H.; Madeira, M.S.; Alfaia, C.M.; Lopes, P.A.; Pinto, R.M.A.; et al. "Impact of dietary incorporation of Spirulina (Arthrospira platensis) and exogenous enzymes on broiler performance, carcass traits, and meat quality". Poultry Science 99 5 (2020): 2519-2532. http://dx.doi.org/10.1016/j.psj.2019.11.069.
    10.1016/j.psj.2019.11.069
  12. Sharma, Kedar; Fontes, Carlos M. G. A.; Najmudin, Shabir; Goyal, Arun. "Small angle X-ray scattering based structure, modeling and molecular dynamics analyses of family 43 glycoside hydrolase a-L-arabinofuranosidase from Clostridium thermocellum". Journal of Biomolecular Structure and Dynamics 39 1 (2019): 209-218. http://dx.doi.org/10.1080/07391102.2019.1707119.
    10.1080/07391102.2019.1707119
  13. Diana O. Ribeiro; Aldino Viegas; Virgínia M. R. Pires; João Medeiros-Silva; Pedro Bule; Wengang Chai; Filipa Marcelo; et al. "Molecular basis for the preferential recognition of ß1,3-1,4-glucans by the family 11 carbohydrate-binding module from Clostridium thermocellum". The FEBS Journal (2019): https://doi.org/10.1111/febs.15162.
    10.1111/febs.15162
  14. Coelho, D.; Lopes, P.A.; Cardoso, V.; Ponte, P.; Brás, J.; Madeira, M.S.; Alfaia, C.M.; et al. "A two-enzyme constituted mixture to improve the degradation of Arthrospira platensis microalga cell wall for monogastric diets". Journal of Animal Physiology and Animal Nutrition (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074751169&partnerID=MN8TOARS.
    10.1111/jpn.13239
  15. Chong, S.L.; Cardoso, V.; Brás, J.L.A.; Gomes, M.Z.D.V.; Fontes, C.M.G.A.; Olsson, L.. "Immobilization of bacterial feruloyl esterase on mesoporous silica particles and enhancement of synthetic activity by hydrophobic-modified surface". Bioresource Technology 293 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071631266&partnerID=MN8TOARS.
    10.1016/j.biortech.2019.122009
  16. Sharma, K.; Fontes, C.M.G.A.; Najmudin, S.; Goyal, A.. "Molecular organization and protein stability of the Clostridium thermocellum glucuronoxylan endo-ß-1,4-xylanase of family 30 glycoside hydrolase in solution". Journal of Structural Biology 206 3 (2019): 335-344. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064173596&partnerID=MN8TOARS.
    10.1016/j.jsb.2019.04.005
  17. Cerullo, G.; Varriale, S.; Bozonnet, S.; Antonopoulou, I.; Christakopoulos, P.; Rova, U.; Gherbovet, O.; et al. "Directed evolution of the type C feruloyl esterase from Fusarium oxysporum FoFaeC and molecular docking analysis of its improved variants". New Biotechnology 51 (2019): 14-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061183564&partnerID=MN8TOARS.
    10.1016/j.nbt.2019.01.008
  18. Coelho, D.; Lopes, P.A.; Cardoso, V.; Ponte, P.; Brás, J.; Madeira, M.S.; Alfaia, C.M.; et al. "Novel combination of feed enzymes to improve the degradation of Chlorella vulgaris recalcitrant cell wall". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85063731508&partnerID=MN8TOARS.
    10.1038/s41598-019-41775-0
  19. Strazzulli, A.; Cobucci-Ponzano, B.; Iacono, R.; Giglio, R.; Maurelli, L.; Curci, N.; Schiano-di-Cola, C.; et al. "Discovery of hyperstable carbohydrate-active enzymes through metagenomics of extreme environments". FEBS Journal (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074341447&partnerID=MN8TOARS.
    10.1111/febs.15080
  20. Goyal, D.; Kumar, K.; Centeno, M.S.J.; Thakur, A.; Pires, V.M.R.; Bule, P.; Fontes, C.M.G.A.; Goyal, A.. "Molecular Cloning, Expression and Biochemical Characterization of a Family 5 Glycoside Hydrolase First Endo-Mannanase (RfGH5_7) from Ruminococcus flavefaciens FD-1 v3". Molecular Biotechnology 61 11 (2019): 826-835. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071038836&partnerID=MN8TOARS.
    10.1007/s12033-019-00205-2
  21. Andriy Kryshtafovych; Reinhard Albrecht; Arnaud Baslé; Pedro Bule; Alessandro T. Caputo; Ana Luisa Carvalho; Kinlin L. Chao; et al. "Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)". Proteins: Structure, Function, and Bioinformatics 86 (2018): 27-50. https://doi.org/10.1002/prot.25392.
    10.1002/prot.25392
  22. Bule, P.; Pires, V.M.R.; Alves, V.D.; Carvalho, A.L.; Prates, J.A.M.; Ferreira, L.M.A.; Smith, S.P.; et al. "Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85046619629&partnerID=MN8TOARS.
    10.1038/s41598-018-25171-8
  23. Cardoso, V.; Fernandes, E.A.; Santos, H.M.M.; Maçãs, B.; Lordelo, M.M.; Telo da Gama, L.; Ferreira, L.M.A.; Fontes, C.M.G.A.; Ribeiro, T.. "Variation in levels of non-starch polysaccharides and endogenous endo-1,4-ß-xylanases affects the nutritive value of wheat for poultry". British Poultry Science 59 2 (2018): 218-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043449490&partnerID=MN8TOARS.
    10.1080/00071668.2018.1423674
  24. Bule, P.; Cameron, K.; Prates, J.A.M.; Ferreira, L.M.A.; Smith, S.P.; Gilbert, H.J.; Bayer, E.A.; et al. "Structure-function analyses generate novel specificities to assemble the components of multienzyme bacterial cellulosome complexes". Journal of Biological Chemistry 293 11 (2018): 4201-4212. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044136990&partnerID=MN8TOARS.
    10.1074/jbc.RA117.001241
  25. Kumar, K.; Correia, M.A.S.; Pires, V.M.R.; Dhillon, A.; Sharma, K.; Rajulapati, V.; Fontes, C.M.G.A.; Carvalho, A.L.; Goyal, A.. "Novel insights into the degradation of ß-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase". International Journal of Biological Macromolecules 117 (2018): 890-901. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048200641&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2018.06.003
  26. Bule, P.; Pires, V.M.; Fontes, C.M.; Alves, V.D.. "Cellulosome assembly: paradigms are meant to be broken!". Current Opinion in Structural Biology 49 (2018): 154-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044480888&partnerID=MN8TOARS.
    10.1016/j.sbi.2018.03.012
  27. Varriale, S.; Cerullo, G.; Antonopoulou, I.; Christakopoulos, P.; Rova, U.; Tron, T.; Fauré, R.; et al. "Evolution of the feruloyl esterase MtFae1a from Myceliophthora thermophila towards improved catalysts for antioxidants synthesis". Applied Microbiology and Biotechnology 102 12 (2018): 5185-5196. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045854653&partnerID=MN8TOARS.
    10.1007/s00253-018-8995-4
  28. Ribeiro, T.; Cardoso, V.; Ferreira, L.M.A.; Lordelo, M.M.S.; Coelho, E.; Moreira, A.S.P.; Domingues, M.R.M.; et al. "Xylo-oligosaccharides display a prebiotic activity when used to supplement wheat or corn-based diets for broilers". Poultry science 97 12 (2018): 4330-4341. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059223826&partnerID=MN8TOARS.
    10.3382/ps/pey336
  29. Lee, S.A.; Apajalahti, J.; Vienola, K.; González-Ortiz, G.; Fontes, C.M.G.A.; Bedford, M.R.. "Age and dietary xylanase supplementation affects ileal sugar residues and short chain fatty acid concentration in the ileum and caecum of broiler chickens". Animal Feed Science and Technology 234 (2017): 29-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034630412&partnerID=MN8TOARS.
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  30. Israeli-Ruimy, V.; Bule, P.; Jindou, S.; Dassa, B.; Moraïs, S.; Borovok, I.; Barak, Y.; et al. "Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85012036956&partnerID=MN8TOARS.
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  32. Sequeira, A.F.; Turchetto, J.; Saez, N.J.; Peysson, F.; Ramond, L.; Duhoo, Y.; Blémont, M.; et al. "Gene design, fusion technology and TEV cleavage conditions influence the purification of oxidized disulphide-rich venom peptides in Escherichia coli". Microbial Cell Factories 16 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009962354&partnerID=MN8TOARS.
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  188. Clarke, J.H.; Davidson, K.; Gilbert, H.J.; Fontes, C.M.G.A.; Hazlewood, G.P.. "A modular xylanase from mesophilic Cellulomonas fimi contains the same cellulose-binding and thermostabilizing domains as xylanases from thermophilic bacteria". FEMS Microbiology Letters 139 1 (1996): 27-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030012798&partnerID=MN8TOARS.
    10.1016/0378-1097(96)00101-2
  189. Fontes, C.M.G.A.; Hazlewood, G.P.; Morag, E.; Hall, J.; Hirst, B.H.; Gilbert, H.J.. "Evidence for a general role for non-catalytic thermostabilizing domains in xylanases from thermophilic bacteria". Biochemical Journal 307 1 (1995): 151-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028949132&partnerID=MN8TOARS.
  190. Fontes, C.M.G.A.; Hall, J.; Hirst, B.H.; Hazlewood, G.P.; Gilbert, H.J.. "The resistance of cellulases and xylanases to proteolytic inactivation". Applied Microbiology and Biotechnology 43 1 (1995): 52-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028956723&partnerID=MN8TOARS.
    10.1007/s002530050369
Capítulo de livro
  1. Alves, Victor D.; Fontes, Carlos M. G. A.; Bule, Pedro. "Cellulosomes: Highly Efficient Cellulolytic Complexes". In Macromolecular Protein Complexes III: Structure and Function, 323-354. Springer International Publishing, 2020.
    10.1007/978-3-030-58971-4_9
  2. Duhoo, Y.; Girault, V.; Turchetto, J.; Ramond, L.; Durbesson, F.; Fourquet, P.; Nominé, Y.; et al. "High-throughput production of a new library of human single and tandem PDZ domains allows quantitative PDZ-peptide interaction screening through high-throughput holdup assay". 439-476. 2019.
    10.1007/978-1-4939-9624-7_21
  3. Duhoo, Y.; Sequeira, A.F.; Saez, N.J.; Turchetto, J.; Ramond, L.; Peysson, F.; Brás, J.L.A.; et al. "High-throughput production of oxidized animal toxins in escherichia coli". 165-190. 2019.
    10.1007/978-1-4939-9624-7_7
Livro
  1. Sequeira, A.F.; Brás, J.L.A.; Fernandes, V.O.; Guerreiro, C.I.P.D.; Vincentelli, R.; Fontes, C.M.G.A.. A novel platform for high-throughput gene synthesis to maximize recombinant expression in Escherichia coli. 2017.
    10.1007/978-1-4939-7060-5_7
  2. Stern, J.; Artzi, L.; Moraïs, S.; Fontes, C.M.G.A.; Bayer, E.A.. Carbohydrate depolymerization by intricate cellulosomal systems. 2017.
    10.1007/978-1-4939-6899-2_8
  3. Brás, J.L.A.; Carvalho, A.L.; Viegas, A.; Najmudin, S.; Alves, V.D.; Prates, J.A.M.; Ferreira, L.M.A.; et al. Escherichia coli expression, purification, crystallization, and structure determination of bacterial cohesin-dockerin complexes. 2012.
    10.1016/B978-0-12-415931-0.00021-5
  4. Fontes, C.M.G.A.; Gilbert, H.J.. Cellulosomes: Highly efficient nanomachines designed to deconstruct plant cell wall complex carbohydrates. 2010.
    10.1146/annurev-biochem-091208-085603
  5. Ali, S.; Hall, J.; Soole, K.L.; Fontes, C.M.G.A.; Hazlewood, G.P.; Hirst, B.H.; Gilbert, H.J.. Targeted expression of microbial cellulases in transgenic animals. 1995.
    10.1016/S0921-0423(06)80111-5
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017 - 2021 Improving the nutritional value of microalgae for feeding pigs through the use of novel enzymes
Coorientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa, Portugal
2015 - 2019 High-Throughput (HTP) production and characterization of Carbohydrate-Active enZYmes (CAZYmes) for animal nutrition
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa, Portugal
2013 - 2017 Divergent cellulosome architecture in rumen bacteria: structure and function studies in cohesion-dockerin complexes of Ruminococcus flavefaciens
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2012 - 2016 Development of a novel platform for high-throughput gene design and artificial gene synthesis to produce large libraries of recombinant venom peptides for drug discovery
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2011 - 2015 Structure and Function of novel Carbohydrate-Active Enzymes (CAZymes) and Carbohydrate-Binding Modules (CBMs) involved in Plant Cell Wall degradation
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2011 - 2015 Structure and function relationships in novel cohesin dockerin complexes
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2009 - 2013 Genetic and metabolic regulation of fatty acid deposition in autochthonous bovine breeds with distinct genetic background
Coorientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2009 - 2013 Discovering novel Carbohydrate-Active Enzymes in the cellulosome of anaerobic bacteria bacteria
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2008 - 2012 Structure and function relationships in novel cellulosomal enzymes and cohesin-dockerin complexes
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2006 - 2010 Novel Insight into the Mechanism of cellulosome assembly and plant cell wall hydrolysis in anaerobic bacteria
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2006 - 2010 Structural and functional insights into the role of Carbohydrate Esterases and Carbohydrate-Binding Modules in plant cell wall hydrolysis
Coorientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2005 - 2009 Rational use of dietary enzymes and lipids to improve broiler performance and meat quality
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2004 - 2008 Effect of pasture biomass intake on growth performance and meat quality of free-range broilers
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2004 - 2008 Molecular mechanisms of plant cell wall hydrolysis: developing novel biotechnological applications for carbohydrate-binding modules
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2004 - 2008 Structure and function of non-catalytic modules involved in plant cell hydrolysis: exogenous enzymes to improve the nutritive value of a Lupinus albus based diet for piglets
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2003 - 2007 Estrutura e função de hemicelulases e complexos coesina-doquerina: implicações relativas à hidrólise de carbohidratos estruturais
Orientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2003 - 2007 Caracterização e modificação genética de polissacaridases tendo em vista a sua utilização na alimentação de animais monogástricos
Coorientador
 Ciências Veterinárias (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal