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António Paulo (AP) has a PhD degree in Chemistry (IST, 1998) and is Coordinator Researcher at the Radiopharmaceutical Sciences Group (RSG) from C2TN/IST. He is involved mainly in the study of metal-based compounds aiming their application in the design of novel radiopharmaceuticals. Currently, his main research interests are focused on molecular and nanometric (radio)compounds for imaging and/or therapy of cancer, based on peptidic molecules, beta- and Auger-emitting radiometals and gold nanoparticles. To perform this research work, AP has established a strong network of collaborators in Europe, USA and Brazil, and succeeded to secure significant funding in competitive calls at National and European level. AP has been the coordinator of 10 projects funded by the FCT (4 of them during the past 5 years), which corresponded to an overall FCT-funding of ca. 1 million euros. He participates or has participated as a team member in 18 other projects funded by the FCT, ANI, industrial partners (e.g. Covidien, ex- Mallinckrodt LLC (USA)) and the European Commision. In his field of expertise, António Paulo (H index 34 and i10 index 95) authored 138 manuscripts (45 of them in the past 5 years) in international peer-reviewed journals, 6 book chapters and is the inventor/co-inventor of 3 international patents. AP supervised 7 PhD theses and co-supervised 4 PhD theses (4 of them ongoing), and supervised 11 MSc dissertations.
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Identificação

Identificação pessoal

Nome completo
António Paulo

Nomes de citação

  • Paulo, António

Identificadores de autor

Ciência ID
C11C-240A-50DB
ORCID iD
0000-0002-9164-0913

Endereços de correio eletrónico

  • apaulo@ctn.tecnico.ulisboa.pt (Profissional)
  • apaulo@ctn.tecnico.ulisboa.pt (Profissional)
  • apaulo@itn.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Formação
Grau Classificação
2021/01/14
Concluído
 António Paulo (Título de Agregado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1998
Concluído
 Departamento de Engenharia Química (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Poli-hidretos e Oxo-complexos de Rénio com Boratos de Polipirazolilo" (TESE/DISSERTAÇÃO)
 PhD degree with honour
1986
Concluído
 Ciências de Engenharia - Engenharia Química (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
 15(20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/02/01 - Atual Investigador Coordenador (carreira) (Investigação) Centro de Ciências e Tecnologias Nucleares, Portugal
Projetos

Bolsa

Designação Financiadores
2020/09/01 - 2021/04/30 In-beam Time-of-Flight Positron Emission Tomography guided proton radiation therapy
BL 68-IST/2020
Universidade de Lisboa Instituto Superior Técnico, Portugal
Em curso

Projeto

Designação Financiadores
2020/11 - Atual Organelle-Targeted Radiocomplexes for Auger Therapy of Cancer
PTDC/MED-QUI/1554/2020
Investigador responsável
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/10/01 - Atual Augmented cooperation in education and training in nuclear and radiochemistry (A-CINCH)
945301
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal
 EU Framework Programme for Research and Innovation Euratom
Em curso
2022/06/01 - 2026/05/31 Building European Nuclear Competence through continuous Advanced and Structural Education and Training Actions
101061677
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal
 EU Framework Programme for Research and Innovation Euratom
Em curso
2021/01/03 - 2024/02/29 The european medical isotope programme: production of high purity isotopes by mass separation
101008571
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
 European Commission
Em curso
2022/04/01 - 2023/03/31 Theranostic Strategy for Proton Boron Capture Therapy of Pancreatic Cancer
UTAP-EXPL/FMT/0020/2021
Investigador responsável
Centro de Ciências e Tecnologias Nucleares, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - 2022/12/01 TOF-PET for Proton Therapy (TPPT)
LISBOA-01-0247-FEDER-045904
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
2018/09 - 2021/08 Multifunctional nanoseeds for chemoradiotherapy of glioblastoma
PTDC/MED-QUI/29649/2017
PTDC/MED-QUI/29649/2017
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 Centre for Nuclear Sciences and Technologies
UID/Multi/04349/2019
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2017/03/01 - 2019/12/31 Radiolabeled and clickable antagonists for targeted radionuclide therapy
CT/Polonia -2017/20
Investigador responsável
Em curso
2018/11 - 2019/10 Drug Delivery nanosystem for HPV infection therapy
UTAP-EXPL/NTec/0015/2017
UTAP-EXPL/NTec/0015/2017
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2015/04/01 - 2019/03/31 MEDICIS-produced radioisotope beams for medicine
info:eu-repo/grantAgreement/EC/H2020/642889/EU
Investigador
European Commission
Concluído
2014/01/01 - 2016/12/31 Metal-based compounds relevant for nuclear medicine applications
FCT-CAPES, 2014-2016.
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2013/06/01 - 2016/11/30 Sistemas Moleculares e Nano para Teranóstica de Cancro
EXCL/QEQ-MED/0233/2012
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Aveiro, Portugal

Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Universidade de Coimbra, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/06/01 - 2016/05/31 Molecular and Nano Tools for Cancer Theranostics
info:eu-repo/grantAgreement/FCT/3599-PPCDT/126789/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2012/01/01 - 2014/12/31 Target-specific and heterobimetallic platinum complexes: synthesis, characterization and mechanistic studies
Acção Nº E-23/12
Acção Nº E-23/12
Investigador
´Conselho de Reitores das Universidades Portuguesas
Concluído
2011/04 - 2014/10 Synthesis and Pre-clinical Evaluation of Novel Estradiol-Based Indium Complexes for Targeted Radiotherapy of Tumors
Provided by PTCRIS: 111891
PTDC/QUI-QUI/111891/2009
Universidade de Coimbra, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2014/08/31 Targeting telomerase inhibition with new anti-tumoral Cu(II) complexes
info:eu-repo/grantAgreement/FCT/3599-PPCDT/114139/PT
 European Commission
Concluído
2010/01/01 - 2013/06/30 Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation
info:eu-repo/grantAgreement/FCT/3599-PPCDT/102049/PT
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide
PTDC/QUI-QUI/102049/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/01 - 2012/10/31 Chemical, Radiochemical and Biological Studies of Pyrazolyl-Alkylamine Pt(II) Complexes: Application on the Development of Novel Anti-cancer Drugs
info:eu-repo/grantAgreement/FCT/3599-PPCDT/66813/PT
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/01 - 2012/10/31 Estudos Químicos, Radioquímicos e Biológicos de Complexos de Pt II com Ligandos Pirazolo-Alquilamina: Aplicações no Desenvolvimento de Novos Agentes Anti-cancerígenos
PTDC/QUI/66813/2006
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2006/01/01 - 2008/12/31 99mTc complexes for Myocardial Imaging
Research Contract/Tyco/Healthcare, 2006-2008
Investigador responsável
Mallinckrodt LLC
Concluído
2005/01/01 - 2007/12/31 Novel Radioactive Probes for Molecular Imaging of Sigma Receptors
info:eu-repo/grantAgreement/FCT/3599-PPCDT/82112/PT
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2005/10/01 - 2007/12/07 Multicomponent Technetium and Gallium Metallointercalators for Targeted Radiotherapy
info:eu-repo/grantAgreement/FCT/POCI/57632/PT
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2002/01/01 - 2005/01/31 Organometallic Rhenium and Technetium Complexes: Design of Radiopharmaceuticals for Brain Receptor Imaging
POCTI/QUI/42939/2001
POCTI/QUI/42939/2001
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
1999/01/01 - 2001/12/01 Rhenium complexes with nitrogen donor ligands: synthesis, characterization and catalytic studies
Praxis/C/QUI/10047/1998
Investigador
Concluído

Outro

Designação Financiadores
2020/10/01 - Atual COST CA19114: “Network for Optimized Astatine labeled Radiopharmaceuticals”
-
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
2019 - Atual COST NANO2CLINIC : "Cancer Nanomedicine - from the bench to the bedside”
-
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
Em curso
2012 - 2016 COST CM1105: "Functional metal complexes that bind to biomolecule”
-
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
Concluído
2011 - 2015 COST TD1007 : "Bimodal PET-MRI molecular imaging technologies and applications for in vivo monitoring of disease and biological processes”
-
Investigador
2007 - 2011 COST BM0607: “Targeted Radionuclide Therapy (TRNT)”
-
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
2006 - 2011 COST D38 : “Metal-Based Systems for Molecular Imaging Applications”
-
Investigador
Centro de Ciências e Tecnologias Nucleares, Portugal
Concluído
Produções

Publicações

Artigo em conferência
  1. Antunes, Joana; Mendes, Filipa; Paulo, António; Sampaio, Jorge. Autor correspondente: Antunes, Joana. "Modeling the radiobiological effects of gold nanoparticles in proton therapy of glioblastomas". 2021.
    10.22323/1.380.0040
Artigo em revista
  1. Palma, Elisa; Içhedef, Cigdem; Fernandes, Célia; Belchior, Ana; Raposinho, Paula; Gano, Lurdes; Miranda, André; et al. "Front Cover: Targeting of G-quadruplex DNA with 99mTc(I)/Re(I) Tricarbonyl Complexes Carrying Pyridostatin Derivatives (Chem. Eur. J. 22/2024)". Chemistry – A European Journal 30 22 (2024): http://dx.doi.org/10.1002/chem.202401135.
    10.1002/chem.202401135
  2. Lourenço, Pedro; Miranda, André; Campello, Maria Paula Cabral; Paulo, António; Louis-Mergny, Jean; Cruz, Carla. Autor correspondente: Cruz, Carla. "Targeting proto-oncogene B-MYB G-quadruplex with a nucleic acid–based fluorescent probe". International Journal of Biological Macromolecules 266 (2024): 131055. http://dx.doi.org/10.1016/j.ijbiomac.2024.131055.
    Publicado • 10.1016/j.ijbiomac.2024.131055
  3. Palma, Elisa; Içhedef, Cigdem; Fernandes, Célia; Belchior, Ana; Raposinho, Paula; Gano, Lurdes; Miranda, André; et al. "Targeting of G–quadruplex DNA with 99mTc(I)/Re(I) Tricarbonyl Complexes Carrying Pyridostatin Derivatives". Chemistry – A European Journal (2024): http://dx.doi.org/10.1002/chem.202400285.
    10.1002/chem.202400285
  4. Antunes, Joana; Pinto, Catarina Isabel; Campello, Maria Paula; Santos, Pedro; Mendes, Filipa; Paulo, António; Sampaio, Jorge Miguel. "Utility of realistic microscopy-based cell models in simulation studies of nanoparticle-enhanced photon radiotherapy". Biomedical Physics & Engineering Express (2024): http://dx.doi.org/10.1088/2057-1976/ad2020.
    10.1088/2057-1976/ad2020
  5. Elisa Palma; Joana F. Santos; Célia Fernandes; António Paulo. "DNA-Targeted Complexes of Tc and Re for Biomedical Applications". Chemistry – A European Journal (2024): https://doi.org/10.1002/chem.202303591.
    10.1002/chem.202303591
  6. Joana F. Santos; Maria T. Braz; Paula Raposinho; Frederik Cleeren; Irwin Cassells; Simon Leekens; Christopher Cawthorne; et al. "Synthesis and Preclinical Evaluation of PSMA-Targeted 111In-Radioconjugates Containing a Mitochondria-Tropic Triphenylphosphonium Carrier". Molecular Pharmaceutics (2024): https://doi.org/10.1021/acs.molpharmaceut.3c00787.
    10.1021/acs.molpharmaceut.3c00787
  7. Lopes-Nunes, Jéssica; Simões, Pedro; Moreira, David; Leandro, Kevin; Nobre, Rui Jorge; de Almeida, Luís Pereira; Campello, Maria Paula Cabral; et al. "RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation". International Journal of Biological Macromolecules (2024): 129157. http://dx.doi.org/10.1016/j.ijbiomac.2023.129157.
    10.1016/j.ijbiomac.2023.129157
  8. Bolcaen, Julie; Gizawy, Mohamed A.; Terry, Samantha Y.A.; Paulo, António; Cornelissen, Bart; Korde, Aruna; Engle, Jonathan; Radchenko, Valery; Howell, Roger W.. "Marshalling the Potential of Auger Electron Radiopharmaceutical Therapy". Journal of Nuclear Medicine 64 9 (2023): 1344-1351. http://dx.doi.org/10.2967/jnumed.122.265039.
    10.2967/jnumed.122.265039
  9. Santos, Tiago; Silva, Micael; Imbert, Lionel; Campello, Maria P. C.; Paulo, António; Amrane, Samir; Salgado, Gilmar F.; Cruz, Carla; Cabrita, Eurico J.. "Structural Perspective into the Interaction of an Oncogenesis-Relevant pre-miRNA G-Quadruplex Ligand Carrier with the Protein Nucleolin". Chemistry – A European Journal 29 39 (2023): http://dx.doi.org/10.1002/chem.202301181.
    10.1002/chem.202301181
  10. David Moreira; Jéssica Lopes-Nunes; Fátima Milhano Santos; Maria Paula Cabral Campello; Maria Cristina Oliveira; António Paulo; Cândida Tomaz; Carla Cruz. "Assessment of Aptamer as a Potential Drug Targeted Delivery for Retinal Angiogenesis Inhibition". Pharmaceuticals (2023): https://doi.org/10.3390/ph16050751.
    10.3390/ph16050751
  11. Leitao, Renan C.F.; Silva, Francisco; Ribeiro, Gabriel H.; Santos, Isabel C.; Guerreiro, Joana F.; Mendes, Filipa; Batista, Alzir A.; et al. "Gallium and indium complexes with isoniazid-derived ligands: Interaction with biomolecules and biological activity against cancer cells and Mycobacterium tuberculosis". Journal of Inorganic Biochemistry 240 (2023): 112091. http://dx.doi.org/10.1016/j.jinorgbio.2022.112091.
    10.1016/j.jinorgbio.2022.112091
  12. Silva, Francisco; Mendes, Carolina; D'Onofrio, Alice; Campello, Maria Paula Cabral; Marques, Fernanda; Pinheiro, Teresa; Gonçalves, Kyle; et al. "Image-Guided Nanodelivery of Pt(IV) Prodrugs to GRP-Receptor Positive Tumors". Nanotheranostics 7 1 (2023): 22-40. http://dx.doi.org/10.7150/ntno.78807.
    10.7150/ntno.78807
  13. Battistin, Federica; Fernandes, Célia; Raposinho, Paula. D.; Blacque, Olivier; Paulo, António; Alberto, Roger. "In vivo and in vitro studies of [M(¿6-pseudoerlotinib)2]+ sandwich complexes (M = Re, 99mTc)". Dalton Transactions 52 43 (2023): 15757-15766. http://dx.doi.org/10.1039/d3dt03011c.
    10.1039/d3dt03011c
  14. André Miranda; Roi Lopez-Blanco; Jéssica Lopes-Nunes; Ana M. Melo; Maria Paula Cabral Campello; António Paulo; Maria Cristina Oliveira; et al. "Gallic Acid–Triethylene Glycol Aptadendrimers Synthesis, Biophysical Characterization and Cellular Evaluation". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14112456.
    10.3390/pharmaceutics14112456
  15. Alice D'Onofrio; Francisco Silva; L. Gano; Raposinho PD; Célia Fernandes; Arkadiusz Sikora; Monika Wyczólkowska; et al. "Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/12/2569.
    10.3390/pharmaceutics14122569
  16. Mamdouh, Ayat-Allah; Ibrahim, Ahmed B. M.; Reyad, Nour El-Houda A.; Elsayed, Tarek R.; Santos, Isabel Cordeiro; Paulo, António; Mahfouz, Refaat M.. "(NH4)2[Co(H2O)6]2V10O28·4H2O Vs. (NH4)2[Ni(H2O)6]2V10O28·4H2O: Structural, Spectral and Thermal Analyses and Evaluation of Their Antibacterial Activities". Journal of Cluster Science (2022): http://dx.doi.org/10.1007/s10876-022-02326-2.
    10.1007/s10876-022-02326-2
  17. Korde, Aruna; Mikolajczak, Renata; Kolenc, Petra; Bouziotis, Penelope; Westin, Hadis; Lauritzen, Mette; Koole, Michel; et al. "Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals". EJNMMI Radiopharmacy and Chemistry 7 1 (2022): http://dx.doi.org/10.1186/s41181-022-00168-x.
    10.1186/s41181-022-00168-x
  18. Célia Fernandes; Elisa Palma; Francisco Silva; Ana Belchior; Catarina I. G. Pinto; Joana F. Guerreiro; Hugo M. Botelho; et al. "Searching for a Paradigm Shift in Auger-Electron Cancer Therapy with Tumor-Specific Radiopeptides Targeting the Mitochondria and/or the Cell Nucleus". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23137238.
    10.3390/ijms23137238
  19. Ana Marques; Ana Belchior; Francisco Silva; Fernanda Marques; Maria Paula Cabral Campello; Teresa Pinheiro; Pedro Santos; et al. "Dose Rate Effects on the Selective Radiosensitization of Prostate Cells by GRPR-Targeted Gold Nanoparticles". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23095279.
    10.3390/ijms23095279
  20. Mamdouh, Ayat-Allah; Ibrahim, Ahmed B.M.; Reyad, Nour El-Houda A.; Elsayed, Tarek R.; Santos, Isabel Cordeiro; Paulo, António; Mahfouz, Refaat M.. "Monoclinic- vs. triclinic-(NH4)2[Mg(H2O)6]2V10O28·4H2O: Structural studies and variation in antibacterial activities with the polymorph type". Journal of Molecular Structure 1253 (2022): 132247. http://dx.doi.org/10.1016/j.molstruc.2021.132247.
    10.1016/j.molstruc.2021.132247
  21. Joana Figueiredo; David Peitinho; Maria Paula Cabral Campello; Maria Cristina Oliveira; António Paulo; Jean-Louis Mergny; Carla Cruz. "Screening of Scaffolds for the Design of G-Quadruplex Ligands". Applied Sciences 12 4 (2022): 2170-2170. https://doi.org/10.3390/app12042170.
    10.3390/app12042170
  22. Maocha, Izamara Gomes; Carvalho, Josué; Lopes-Nunes, Jéssica; Rosado, Tiago; Gallardo, Eugénia; Tomás, Mariana; Palmeira-de-Oliveira, Ana; et al. "Drug formulations for localized treatment of Human Papillomavirus-induced lesions". Journal of Pharmaceutical Sciences (2022): http://dx.doi.org/10.1016/j.xphs.2022.02.004.
    10.1016/j.xphs.2022.02.004
  23. Santos, Tiago; Miranda, André; Imbert, Lionel; Jardim, Andreia; Caneira, Catarina R.F.; Chu, Virgínia; Conde, João P.; et al. "Pre-miRNA-149 G-quadruplex as a molecular agent to capture nucleolin". European Journal of Pharmaceutical Sciences 169 (2022): 106093. http://dx.doi.org/10.1016/j.ejps.2021.106093.
    10.1016/j.ejps.2021.106093
  24. Francisco Silva; Alice D'Onofrio; Carolina Mendes; Catarina Pinto; Ana Marques; M.P.C. Campello; Maria Cristina Oliveira; et al. "Radiolabeled Gold Nanoseeds Decorated with Substance P Peptides: Synthesis, Characterization and In Vitro Evaluation in Glioblastoma Cellular Models". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/2/617.
    10.3390/ijms23020617
  25. Jessica Lopes-Nunes; Ana S. Agonia; Tiago Rosado; Eugenia Gallardo; Rita Palmeira-de-Oliveira; Ana Palmeira-de-Oliveira; José Martinez-de-Oliveira; et al. "Aptamer-Functionalized Gold Nanoparticles for Drug Delivery to Gynecological Carcinoma Cells". Cancers (2021): https://www.mdpi.com/2072-6694/13/16/4038.
    10.3390/cancers13164038
  26. Elisa Palma; Josué Carvalho; Carla Cruz; António Paulo. "Metal-Based G-Quadruplex Binders for Cancer Theranostics". Pharmaceuticals (2021): https://doi.org/10.3390/ph14070605.
    10.3390/ph14070605
  27. Mihaela Cudalbeanu; David Peitinho; Francisco Silva; Rosa Marques; Teresa Pinheiro; Ana C. Ferreira; Fernanda Marques; et al. "Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties". Nanomaterials 11 6 (2021): 1562-1562. https://doi.org/10.3390/nano11061562.
    10.3390/nano11061562
  28. D'Onofrio, Alice; Silva, Francisco; Gano, Lurdes; Karczmarczyk, Urszula; Mikolajczak, Renata; Garnuszek, Piotr; Paulo, António. "Clickable Radiocomplexes With Trivalent Radiometals for Cancer Theranostics: In vitro and in vivo Studies". Frontiers in Medicine 8 (2021): http://dx.doi.org/10.3389/fmed.2021.647379.
    10.3389/fmed.2021.647379
  29. Carvalho, Josué; Lopes-Nunes, Jéssica; Vialet, Brune; Rosado, Tiago; Gallardo, Eugenia; Vale, João; Eloy, Catarina; et al. "Nanoaggregate-forming lipid-conjugated AS1411 aptamer AS a promising tumor-targeted delivery system of anticancer agents in vitro". Nanomedicine: Nanotechnology, Biology and Medicine (2021): 102429. http://dx.doi.org/10.1016/j.nano.2021.102429.
    10.1016/j.nano.2021.102429
  30. Palma, Elisa; Raposinho, Paula; Cabral Campello, Maria Paula; Belo, Dulce; Guerreiro, Joana; Alves, Vitor; Fonseca, Alexandra; et al. "Anticancer Activity and Mode of Action of Copper (II)- Bisthiosemicarbazonato Complexes with Pendant Nitrogen Heterocycles". European Journal of Inorganic Chemistry (2021): http://dx.doi.org/10.1002/ejic.202100168.
    10.1002/ejic.202100168
  31. Diogo Figueiredo; Célia Fernandes; Francisco Silva; Elisa Palma; Paula Raposinho; Ana Belchior; Pedro Vaz; António Paulo. "Synthesis and Biological Evaluation of 99mTc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria". Molecules 26 2 (2021): 441-441. https://doi.org/10.3390/molecules26020441.
    10.3390/molecules26020441
  32. D'Onofrio, Alice; Gano, Lurdes; Melo, Rita; Mendes, Filipa; Oliveira, Maria Cristina; Denoël, Thibaut; Schaefer, Niklaus; et al. "Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies". European Journal of Pharmaceutics and Biopharmaceutics 158 (2021): 233-244. http://dx.doi.org/10.1016/j.ejpb.2020.11.015.
    10.1016/j.ejpb.2020.11.015
  33. Prado, Viviana S.; Leitao, Renan C. F.; Silva, Francisco; Gano, Lurdes; Santos, Isabel C.; Marques, Fabio L. N.; Paulo, António; Deflon, Victor M.. "Gallium and indium complexes with new hexadentate bis(semicarbazone) and bis(thiosemicarbazone) chelators". Dalton Transactions 50 5 (2021): 1631-1640. http://dx.doi.org/10.1039/d0dt04028b.
    10.1039/d0dt04028b
  34. Francisco Silva; Maria Paula Cabral Campello; António Paulo. "Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer". Materials (2020): https://doi.org/10.3390/ma14010004.
    10.3390/ma14010004
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  87. Esteves, T.; Marques, F.; Paulo, A.; Rino, J.; Nanda, P.; Smith, C.J.; Santos, I.. "Nuclear targeting with cell-specific multifunctional tricarbonyl M(I) (M is Re, 99mTc) complexes: Synthesis, characterization, and cell studies". Journal of Biological Inorganic Chemistry 16 8 (2011): 1141-1153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84655169705&partnerID=MN8TOARS.
    10.1007/s00775-011-0803-x
  88. Goethals, L.R.; Santos, I.; Caveliers, V.; Paulo, A.; De Geeter, F.; Lurdes, P.G.; Fernandes, C.; Lahoutte, T.. "Rapid hepatic clearance of 99mTc-TMEOP: A new candidate for myocardial perfusion imaging". Contrast Media and Molecular Imaging 6 4 (2011): 178-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051945093&partnerID=MN8TOARS.
    10.1002/cmmi.413
  89. Ribeiro Morais, G.; Vicente Miranda, H.; Santos, I.C.; Santos, I.; Outeiro, T.F.; Paulo, A.. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic and Medicinal Chemistry 19 24 (2011): 7698-7710. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255178997&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.09.065
  90. Moura, C.; Gano, L.; Santos, I.; Santos, I.C.; Paulo, A.. "99mTc I/Re I tricarbonyl complexes with tridentate cysteamine based ligands: Synthesis, characterization and in vitro/in vivo evaluation". European Journal of Inorganic Chemistry 35 (2011): 5405-5413. http://www.scopus.com/inward/record.url?eid=2-s2.0-82955245710&partnerID=MN8TOARS.
    10.1002/ejic.201100796
  91. Mendes, F.; Paulo, A.; Santos, I.. "Metalloprobes for functional monitoring of tumour multidrug resistance by nuclear imaging". Dalton Transactions 40 20 (2011): 5377-5393. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955600298&partnerID=MN8TOARS.
    10.1039/c0dt01275k
  92. Gama, S.; Santos, I.; Mendes, F.; Marques, F.; Santos, I.C.; Carvalho, M.F.; Correia, I.; Pessoa, J.C.; Paulo, A.. "Copper(II) complexes with tridentate pyrazole-based ligands: Synthesis, characterization, DNA cleavage activity and cytotoxicity". Journal of Inorganic Biochemistry 105 5 (2011): 637-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953066808&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2011.01.013
  93. Correia, J.D.G.; Paulo, A.; Raposinho, P.D.; Santos, I.. "Radiometallated peptides for molecular imaging and targeted therapy". Dalton Transactions 40 23 (2011): 6144-6167. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958191536&partnerID=MN8TOARS.
    10.1039/c0dt01599g
  94. Francisco, C.; Gama, S.; Mendes, F.; Marques, F.; Cordeiro Dos Santos, I.; Paulo, A.; Santos, I.; et al. "Pt(ii) complexes with bidentate and tridentate pyrazolyl-containing chelators: Synthesis, structural characterization and biological studies". Dalton Transactions 40 21 (2011): 5781-5792. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957530790&partnerID=MN8TOARS.
    10.1039/c0dt01785j
  95. Batista, Mary; Campello, Maria Paula C.; Paulo, Antonio; Gano, Lurdes; Santos, Isabel. "Gallium complexes with a new DOTA-like chelator bearing a thiol pendant arm: synthesis, characterization and biological studies". Nuclear Medicine and Biology 37 6 (2010): 680-681. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000281075100017&KeyUID=WOS:000281075100017.
    10.1016/j.nucmedbio.2010.04.162
  96. Mendes, F.; Gano, L.; Fernandes, C.; Paulo, A.; Santos, I.. "Evaluation of (99)mTc-TMEOP as Probe for Functional Monitoring of Multidrug Resistance". European Journal of Nuclear Medicine and Molecular Imaging 37 (2010): S358-S358. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000283023801128&KeyUID=WOS:000283023801128.
  97. Silva, Francisco; Morais, Mauricio; Raposinho, Paula D.; Paula, M.; Carvell, C.; Correia, Joao D. G.; Paulo, Antonio; Santos, Isabel. "PEGylated DOTA-alpha-MSH analogues for in vivo targeting of melanoma". Nuclear Medicine and Biology 37 6 (2010): 694-694.
    10.1016/j.nucmedbio.2010.04.103
  98. Silva, F.; Marques, F.; Santos, I.C.; Paulo, A.; Rodrigues, A.S.; Rueff, J.; Santos, I.. "Synthesis, characterization and cytotoxic activity of gallium(III) complexes anchored by tridentate pyrazole-based ligands". Journal of Inorganic Biochemistry 104 5 (2010): 523-532. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950691262&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2010.01.003
  99. Moura, C.; Esteves, T.; Gano, L.; Raposinho, P.D.; Paulo, A.; Santos, I.; Garcia, R.; et al. "Synthesis, characterization and biological evaluation of tricarbonyl M(i) (M = Re, 99mTc) complexes functionalized with melanin-binding pharmacophores". New Journal of Chemistry 34 11 (2010): 2564-2578. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049263952&partnerID=MN8TOARS.
    10.1039/c0nj00256a
  100. Esteves, T.; Xavier, C.; Gama, S.; Mendes, F.; Raposinho, P.D.; Marques, F.; Paulo, A.; et al. "Tricarbonyl M(I) (M = Re, 99mTc) complexes bearing acridine fluorophores: Synthesis, characterization, DNA interaction studies and nuclear targeting". Organic and Biomolecular Chemistry 8 18 (2010): 4104-4116. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955948795&partnerID=MN8TOARS.
    10.1039/c0ob00073f
  101. Santos, I.; Maria, L.; Fernandes, C.; Garcia, R.; Gano, L.; Paulo, A.; Santos, I.C.. "Tris(pyrazolyl)methane 99mTc tricarbonyl complexes for myocardial imaging". Dalton Transactions 4 (2009): 603-606. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149513007&partnerID=MN8TOARS.
    10.1039/b817451b
  102. Moura, C.; Fernandes, C.; Gano, L.; Paulo, A.; Santos, I.C.; Santos, I.; Calhorda, M.J.. "Influence of the ligand donor atoms on the in vitro stability of rhenium(I) and technetium (I)-99m complexes with pyrazole-containing chelators: Experimental and DFT studies". Journal of Organometallic Chemistry 694 6 (2009): 950-958. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749132724&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2008.11.027
  103. Garcia, R.; Fousková, P.; Gano, L.; Paulo, A.; Campello, P.; Tóth, É.; Santos, I.. "A quinazoline-derivative DOTA-type gallium(III) complex for targeting epidermal growth factor receptors: Synthesis, characterisation and biological studies". Journal of Biological Inorganic Chemistry 14 2 (2009): 261-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-58949100316&partnerID=MN8TOARS.
    10.1007/s00775-008-0446-8
  104. Videira, M.; Silva, F.; Paulo, A.; Santos, I.C.; Santos, I.. "Synthesis and structural studies of mixed-ligand rhenium(V) complexes anchored by tridentate pyrazole-based ligands". Inorganica Chimica Acta 362 8 (2009): 2807-2813. http://www.scopus.com/inward/record.url?eid=2-s2.0-64949201163&partnerID=MN8TOARS.
    10.1016/j.ica.2008.12.032
  105. Videira, M.; Moura, C.; Datta, A.; Paulo, A.; Santos, I.C.; Santos, I.. "Rhenium(I) tricarbonyl complexes with poly(azolyl)borates generated in situ from an organometallic precursor containing the B-H re coordination motif". Inorganic Chemistry 48 9 (2009): 4251-4257. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149121920&partnerID=MN8TOARS.
    10.1021/ic802403u
  106. Vitor, R.F.; Esteves, T.; Marques, F.; Raposinho, P.; Paulo, A.; Rodrigues, S.; Rueff, J.; et al. "99mTc-Tricarbonyl Complexes Functionalized with Anthracenyl Fragments: Synthesis, Characterization, and Evaluation of Their Radiotoxic Effects in Murine Melanoma Cells". Cancer Biotherapy and Radiopharmaceuticals 24 5 (2009): 551-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449113426&partnerID=MN8TOARS.
    10.1089/cbr.2009.0647
  107. Garcia, R.; Paulo, A.; Santos, I.. "Rhenium and technetium complexes with anionic or neutral scorpionates: An overview of their relevance in biomedical applications". Inorganica Chimica Acta 362 12 (2009): 4315-4327. http://www.scopus.com/inward/record.url?eid=2-s2.0-68849112126&partnerID=MN8TOARS.
    10.1016/j.ica.2009.06.034
  108. Videira, M.; Maria, L.; Paulo, A.; Santos, I.; Santos, I.C.; Vaz, P.D.; Calhorda, M.J.. "Mixed-ligand rhenium tricarbonyl complexes anchored on a (¿2-H,S) trihydro(mercaptoimidazolyl)borate: A missing binding motif for soft scorpionates". Organometallics 27 6 (2008): 1334-1337. http://www.scopus.com/inward/record.url?eid=2-s2.0-41749104619&partnerID=MN8TOARS.
    10.1021/om701016y
  109. Vitor, R.F.; Correia, I.; Videira, M.; Marques, F.; Paulo, A.; Costa Pessoa, J.; Viola, G.; Martins, G.G.; Santos, I.. "Pyrazolyl-diamine ligands that bear anthracenyl moieties and their rhenium(I) tricarbonyl complexes: Synthesis, characterisation and DNA-binding properties". ChemBioChem 9 1 (2008): 131-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-38149057217&partnerID=MN8TOARS.
    10.1002/cbic.200700433
  110. Maria, L.; Cunha, S.; Videira, M.; Gano, L.; Paulo, A.; Santos, I.; Santos, I.C.. "Rhenium and technetium tricarbonyl complexes anchored by pyrazole-based tripods: Novel lead structures for the design of myocardial imaging agents". Dalton Transactions 28 (2007): 3010-3019. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547293218&partnerID=MN8TOARS.
    10.1039/b705226j
  111. Garcia, R.; Gano, L.; Maria, L.; Paulo, A.; Santos, I.; Spies, H.. "Synthesis and biological evaluation of tricarbonyl Re(I) and Tc(I) complexes anchored by poly(azolyl)borates: Application on the design of radiopharmaceuticals for the targeting of 5-HT1A receptors". Journal of Biological Inorganic Chemistry 11 6 (2006): 769-782. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746266862&partnerID=MN8TOARS.
    10.1007/s00775-006-0124-7
  112. Moura, C.; Vítor, R.F.; Maria, L.; Paulo, A.; Santos, I.; Santos, I.C.. "Rhenium(v) oxocomplexes with novel pyrazolyl-based N4- and N3S-donor chelators". Dalton Transactions 47 (2006): 5630-5640. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846299962&partnerID=MN8TOARS.
    10.1039/b611034g
  113. Maria, L.; Paulo, A.; Santos, I.C.; Santos, I.; Kurz, P.; Spingler, B.; Alberto, R.. "Very small and soft scorpionates: Water stable technetium tricarbonyl complexes combining a bis-agostic (k3-H, H, S) binding motif with pendant and integrated bioactive molecules". Journal of the American Chemical Society 128 45 (2006): 14590-14598. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750980412&partnerID=MN8TOARS.
    10.1021/ja0644226
  114. Marques, F; Paulo, A; Campello, MP; Lacerda, S; Vitor, RF; Gano, L; Delgado, R; Santos, I. "Radiopharmaceuticals for targeted radiotherapy". Radiation Protection Dosimetry 116 1-4 (2005): 601-604.
    10.1093/rpd/nci251
  115. Santos, I; Paulo, A; Correia, JDG; Krause, W; Santos, I.; Paulo, A.; Correia, J.D.G.. "Rhenium and technetium complexes anchored by phosphines and scorpionates for radiopharmaceutical applications". Contrast Agents Iii: Radiopharmaceuticals - From Diagnostics To Therapeutics 252 (2005): 45-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-20844462760&partnerID=MN8TOARS.
  116. Alves, S.; Paulo, A.; Correia, J.D.G.; Gano, L.; Smith, C.J.; Hoffman, T.J.; Santos, I.. "Pyrazolyl derivatives as bifunctional chelators for labeling tumor-seeking peptides with the fac-[M(CO)3]+ moiety (M = 99mTc, Re): Synthesis, characterization, and biological behavior". Bioconjugate Chemistry 16 2 (2005): 438-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244347266&partnerID=MN8TOARS.
    10.1021/bc0497968
  117. Garcia, R.; Paulo, A.; Domingos, A.; Santos, I.; Pietzsch, H.-J.. "Disruption of unprecedented B-H...M agostic interactions: An alternative approach for labeling bioactive molecules". Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry 35 1 (2005): 35-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-18244396906&partnerID=MN8TOARS.
    10.1081/SIM-200047542
  118. Garcia, R.; Xavier, C.; Paulo, A.; Santos, I.; Kniess, T.; Bergmann, R.; Wüst, F.. "Synthesis and biological evaluation of S-[11C]methylated mercaptoimidazole piperazinyl derivatives as potential radioligands for imaging 5-HT1A receptors by positron emission tomography (PET)". Journal of Labelled Compounds and Radiopharmaceuticals 48 4 (2005): 301-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444420276&partnerID=MN8TOARS.
    10.1002/jlcr.924
  119. Xavier, C.; Paulo, A.; Domingos, A.; Santos, I.; Maria, L.; Moura, C.; Santos, I.C.. "Synthesis and Structural Studies of Rhenium(v) Complexes Stabilized by a Monoanionic Cyclen Ligand". European Journal of Inorganic Chemistry 691 2 (2004): 243-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742288624&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2006.07.032
  120. Paulo, A.; Correia, J.D.G.; Campello, M.P.C.; Santos, I.. "A short ride on scorpionates: From d- to f-elements". Polyhedron 23 2-3 (2004): 331-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842289705&partnerID=MN8TOARS.
    10.1016/j.poly.2003.11.022
  121. Vitor, R.F.; Alves, S.; Correia, J.D.G.; Paulo, A.; Santos, I.. "Rhenium(I)- and technetium(I) tricarbonyl complexes anchored by bifunctional pyrazole-diamine and pyrazole-dithioether chelators". Journal of Organometallic Chemistry 689 25 SPEC. I (2004): 4764-4774. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144277089&partnerID=MN8TOARS.
    10.1016/j.jorganchem.2004.09.033
  122. Garcia, R.; Paulo, A.; Domingos, A.; Santos, I.. "Rhenium(I) tris(carbonyl) complexes with soft scorpionates". Dalton Transactions 13 (2003): 2757-2760. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642561741&partnerID=MN8TOARS.
  123. Garcia, R.; Xing, Y.H.; Domingos, A.; Paulo, A.; Santos, I.. "Rhenium oxocomplexes with the heteroscorpionate phenyltris(pyrazolyl)borate: Synthesis and structural studies". Inorganica Chimica Acta 343 (2003): 27-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037472409&partnerID=MN8TOARS.
    10.1016/S0020-1693(02)01184-2
  124. Garcia, R.; Domingos, A.; Paulo, A.; Santos, I.; Alberto, R.. "Reactivity of [Re{(¿3-H(µ-H)B (timMe)2}(CO)3] (timMe = 2-mercapto-1-methylimidazolyl) toward neutral substrates". Inorganic Chemistry 41 9 (2002): 2422-2428. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037029951&partnerID=MN8TOARS.
    10.1021/ic011171n
  125. Alves, S.; Paulo, A.; Correia, J.D.G.; Domingos, Â.; Santos, I.. "Coordination capabilities of pyrazolyl containing ligands towards the fac-[Re(CO)3]+ moiety". Journal of the Chemical Society. Dalton Transactions 24 (2002): 4714-4719. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037153792&partnerID=MN8TOARS.
  126. Garcia, R.; Xing, Y.-H.; Paulo, A.; Domingos, Â.; Santos, I.. "Rhenium(I) tricarbonyl complexes with mercaptoimidazolylborate ligands bearing piperazine fragments". Journal of the Chemical Society, Dalton Transactions 22 (2002): 4236-4241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036027131&partnerID=MN8TOARS.
  127. Garcia, R.; Paulo, A.; Domingos, A.; Santos, I.. "Rhenium(I) organometallic complexes with novel bis(mercaptoimidazolyl)borates and with hydrotris(mercaptoimidazolyl)borate: Chemical and structural studies". Journal of Organometallic Chemistry 632 1-2 (2001): 41-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001907761&partnerID=MN8TOARS.
    10.1016/S0022-328X(01)00838-5
  128. Garcia, R.; Paulo, A.; Domingos, A.; Santos, I.; Ortner, K.; Alberto, R.. "Re and Tc complexes containing B-H···M agostic interactions as building blocks for the design of radiopharmaceuticals [8]". Journal of the American Chemical Society 122 45 (2000): 11240-11241. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034669513&partnerID=MN8TOARS.
    10.1021/ja002652t
  129. Paulo, A.; Domingos, Â.; Garcia, R.; Santos, I.. "Cationic Re(V) oxo complexes with poly(pyrazolyl)borates: Synthesis, characterization, and stability". Inorganic Chemistry 39 25 (2000): 5669-5674. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034638879&partnerID=MN8TOARS.
    10.1021/ic000481n
  130. Correia, J.D.G.; Domingos, A.; Paulo, A.; Santos, I.. "Novel six-co-ordinate oxorhenium complexes with ligands containing PN2 and PNO donor atom sets: Syntheses and structural characterization". Journal of the Chemical Society, Dalton Transactions 14 (2000): 2477-2482. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001989071&partnerID=MN8TOARS.
    10.1039/b002798g
  131. Rajender Reddy, K.; Domingos, Â.; Paulo, A.; Santos, I.. "Rhenium(V) dioxo complexes with dihydrobis(pyrazolyl)borates: Synthesis and reactivity toward electrophilic substrates". Inorganic Chemistry 38 19 (1999): 4278-4282. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000299828&partnerID=MN8TOARS.
  132. Paulo, A.; Domingos, Â.; Santos, I.. "Control of the hapticity of pyridine-2-thiolate ligands in rhenium(v) oxo complexes". Journal of the Chemical Society - Dalton Transactions 21 (1999): 3735-3740. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748480328&partnerID=MN8TOARS.
  133. Paulo, A.; Ascenso, J.; Domingos, Â.; Galvão, A.; Santos, I.. "Rhenium-(III) and -(V) hydride complexes with modified poly(pyrazolyl)borates". Journal of the Chemical Society - Dalton Transactions 8 (1999): 1293-1300. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748820134&partnerID=MN8TOARS.
  134. Paulo, A.; Rajender Reddy, K.; Domingos, Â.; Santos, I.; Paulo, A; Reddy, KR; Domingos, A; Santos, I. "Neutral trans-Dioxorhenium(V) Complexes with the Anionic Tetrakis(pyrazolyl)borate Ligand". Inorganic Chemistry 37 26 (1998): 6807-6813. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001081734&partnerID=MN8TOARS.
    10.1021/ic950972l
  135. Nunes, D.; Domingos, A.; Paulo, A.; Patrício, L.; Santos, I.; Carvalho, M.F.N.N.; Pombeiro, A.J.L.. "Synthesis, characterization and study of the redox properties of rhenium(V) diolates". Inorganica Chimica Acta 271 1-2 (1998): 65-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-0002930838&partnerID=MN8TOARS.
  136. Paulo, A.; Domingos, Â.; Marçalo, J.; De Matos, A.P.; Santos, I.. "Reactivity of a tetrakis(pyrazolyl)borate oxorhenium complex". Inorganic Chemistry 34 8 (1995): 2113-2120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001253809&partnerID=MN8TOARS.
  137. Paulo, A.; Domingos, Â.; De Matos, A.P.; Santos, I.; Fernanda, M.; Carvalho, N.N.; Pombeiro, A.J.L.. "Synthesis, characterization, and study of the redox properties of rhenium(V) and rhenium(III) compounds with tetrakis(pyrazol-1-yl)borate". Inorganic Chemistry 33 21 (1994): 4729-4737. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000166705&partnerID=MN8TOARS.
  138. Domingos, Â.; Marçalo, J.; Paulo, A.; De Matos, A.P.; Santos, I.. "Synthesis and characterization of rhenium complexes with the stabilizing ligand tetrakis(pyrazol-1-yl)borate". Inorganic Chemistry 32 23 (1993): 5114-5118. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000252239&partnerID=MN8TOARS.
  139. Castanheira, I.; Sawas-dimopoulou, C.; Paulo, A.; Neves, M.; Patricio, L.. "Preparation and biological characteristics of 99mTc-diol a renal agent". Nuclear Medicine and Biology 20 3 (1993): 279-285. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027410222&partnerID=MN8TOARS.
  140. Neves, M.; Paulo, A.; Patricio, L.. "A kit formulation of [131I]meta-iodobenzylguanidine (MIBG) using Cu(I) generated "in situ" by sodium disulphite". International Journal of Radiation Applications and Instrumentation. Part 43 6 (1992): 737-740. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026704624&partnerID=MN8TOARS.
  141. Neves, M.; Paulo, A.; Castanheira, I.; Patricio, L.. "Studies on technetium-99m-labelled monophosphonates: 1,2-Epoxypropylphosphonic acid and its hydrolysed form". Applied Radiation and Isotopes 43 6 (1992): 731-736. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026695062&partnerID=MN8TOARS.
    10.1016/0883-2889(92)90234-6
Capítulo de livro
  1. Paulo, António; Mendes, Filipa; Silva, Francisco; Pinto, Catarina I. G.; Guerreiro, Joana F.. Autor correspondente: Mendes, Filipa. "Radiopharmaceuticals for Molecular Imaging and Theranostics of Glioblastoma". editado por Carla Vitorino; Carmen Balana; Célia Cabral. Elsevier, 2023.
    No prelo
  2. Paulo, António; Gano, Lurdes; Fernandes, Célia. Autor correspondente: Gano, Lurdes. "Radiopharmaceuticals for Gastrointestinal Imaging". In Gastrointestinal Molecular Imaging. Áustria, 2023.
  3. Paulo, António; Lurdes Gano. "Chapter 6: Conventional nuclear medicine radiopharmaceuticals". Áustria, 2020.
    Publicado
  4. Paulo, António; Morais, Goreti Ribeiro; Santos, Isabel. "Organometallic Chemistry of Rhenium and Technetium Fueled by Biomedical Applications". In Advances in Organometallic Chemistry and Catalysis, 589-604. John Wiley & Sons, Inc., 2013.
    10.1002/9781118742952.ch44
  5. Alves, Susana; Vítor, Rute F.; Raposinho, Paula; Marques, Fernanda; Correia, João D. G.; Paulo, António; Santos, I.. "Metal-based drugs for diagnosis and therapy". In Metal Ions in Biologie and Medicine, editado por Alpoim, M. C; Morais, P. V; Santos, M. A.; Cristovão, A. J.; Centeno, J. A.; Collery, P, 3-8. Paris, França: John Libbey Eurotext, 2006.
    Publicado
  6. Santos, Isabel; Paulo, António; Correia, João D. G.. "Rhenium and Technetium Complexes Anchored by Phosphines and Scorpionates for Radiopharmaceutical Applications". In Topics in Current Chemistry, 45-84. Springer Berlin Heidelberg, 2005.
    10.1007/b101224
Livro
  1. Andrea Santos; Luisa Roldao Pereira; Paolo Turco; Erik Rosa-Rizzotto; Diego Caroli; Alessandro Gubbiotti; Lurdes Gano; et al. Gastrointestinal Molecular Imaging. 2023.
    10.52717/IJDW6277
Poster em conferência
  1. Antunes, Joana; Pinto, Catarina I.; Mendes, Filipa; Paulo, António; Sampaio, Jorge. "Gold nanoparticles as radiosensitizers in cancer radiotherapy: a Monte Carlo study". Trabalho apresentado em 9th Mini-School on Particle an Astroparticle Physics, 2024.
  2. Antunes, Joana; Pinto, Catarina I.; Mendes, Filipa; Paulo, António; Sampaio, Jorge. Autor correspondente: Antunes, Joana. "Impact of physical parameters on GBM survival curves in enhanced radiotherapy with gold nanoparticles". Trabalho apresentado em 61st Annual PTCOG Conference, 2023.
  3. Santos, Joana F.; Fernandes, Célia; Braz, Maria Teresa; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; Cleeren, Frederik; et al. "Dual-targeted 111In-Radiocomplexes for Auger Therapy of Prostate Cancer". Trabalho apresentado em International Symposium on Trends in Radiopharmaceuticals, 2023.
  4. Mendes, Filipa; Santos, Joana F.; Maria Teresa Braz; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; Irwin Cassels; et al. Autor correspondente: Mendes, Filipa. "Dual-targeted 111In and 161Tb Complexes for Radionuclide Therapy of Prostate Cancer". Trabalho apresentado em The 2nd International Workshop on Radiobiology of Molecular Radionuclide Therapy, 2023.
  5. Fernandes, Célia; Santos, Joana F.; Maria Teresa Braz; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; Frederik Cleeren; et al. Autor correspondente: Fernandes, Célia. "Mitochondria-targeted Radiocomplexes for Cancer Theranostics". Trabalho apresentado em TERACHEM 2022: Fourth International Symposium on Technetium and Other Radiometals in Chemistry and Medicine, 2022.
  6. Santos, Joana F.; Maria Teresa Braz; Silva, Francisco; Raposinho, Paula; Guerreiro, Joana F.; Frederik Cleeren; Mendes, Filipa; Fernandes, Célia; Paulo, António. Autor correspondente: Santos, Joana F.. "Mitotropic Radiocomplexes for Auger Therapy of Prostate Cancer". Trabalho apresentado em 2nd Chem & BioChem Students Meeting, 2022.
  7. Antunes, Joana; Mendes, Filipa; Paulo, António; Sampaio, Jorge. "Modeling the radiobiological effects of gold nanoparticles in proton therapy". Trabalho apresentado em UT Austin Portugal 2021 Annual Confer, 2021.
  8. Lopes-Nunes, Jéssica; Agonia, Ana S; Rosado, Tiago; Gallardo, Eugénia; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, Ana; Martinez-de-Oliveira, José; et al. "Topical Formulation with AS1411-Gold Nanoparticles as Cervical Cancer Drug Delivery System (Author; presented by: Jéssica Lopes-Nunes)". Trabalho apresentado em Applied Nanotechnology and Nanoscience International Conference ¿ ANNIC 2021, 2021.
  9. Santos, Tiago; Miranda, André; Campello, Maria P. C.; Paulo, António; Salgado, Gilmar; Cabrita, Eurico J.; Cruz, Carla. "Sonda fluorescente de RNA G-quadruplex para diagnóstico do cancro da próstata". Trabalho apresentado em I Semana da Investigação do Centro Hospitalar Universitário Cova da Beira, 2020.
  10. Antunes, Joana; Mendes, Filipa; Paulo, António; Sampaio, Jorge. "Simulation of the Effectiveness of Radiosensitization of Gold Nanoparticles in Proton Therapy". Trabalho apresentado em UT Austin Portugal 2020 Annual Conference, 2020.
  11. Lopes-Nunes, Jéssica; Tomás, Mariana; Agonia, Ana Sofia; Moutinho, José; Gallardo, Eugenia; Palmeira-de-Oliveira, R.; Palmeira-de-Oliveira, A.; et al. "AS1411-GOLD NANOPARTICLES AS CERVICAL CANCER DRUG DELIVERY SYSTEM". Trabalho apresentado em XV ANNUAL CICS-UBI SYMPOSIUM 2020, 2020.
  12. Santos, Tiago; Miranda, André; Campello, Maria P. C.; Paulo, António; Salgado, Gilmar; Cabrita, Eurico J.; Cruz, Carla. "Nucleolin interaction with RNA G-quadruplex formed in the pre-miRNA-92b". Trabalho apresentado em XV Annual CICS-UBI Symposium, 2020.
  13. Cabral Campello, Maria Paula; Lopes-Nunes, Jéssica; Carvalho, Josué; Gano, Lurdes; Oliveira, Maria Cristina; Peitinho, David; Silva, Francisco; Paulo, António; Cruz, Carla. "Evaluation of the cytotoxic activity of the AS1411-AO-nanosystem for HPV cancer therapy (Co-author; presented by: Maria Paula Cabral Campello)". Trabalho apresentado em Nanotechnology in Cancer: Engineering for Oncology, 2019.
  14. Santos, Tiago; Pereira, Patricia; Campello, Maria P. C.; Paulo, António; Cabrita, Eurico J.; Cruz, Carla. "Nucleolin targeting by RNA G-quadruplex of pre-miR-149". Trabalho apresentado em BIONIC 2018, 2018.
Resumo em conferência
  1. Pinto, Catarina I. G.; Teixeira, Ana Rita C.; Silva, Francisco; Guerreiro, Joana F.; Campello, Maria Paula C.; Santos, Pedro; Abrunhosa, Antero J.; Mendes, Filipa; Paulo, António. "Evaluation of the radiosensitizing effect of gold nanoparticles in glioblastoma". Trabalho apresentado em 10th International Symposium on the Physical, Molecular, Cellular and Medical Aspects of Auger Electron Processes, Montpellier, 2023.
    Publicado
  2. Pinto, Catarina I. G.; Silva, Francisco; Guerreiro, Joana F.; Paula Cabral Campello, Maria; Santos, Pedro; Mendes, Filipa; Paulo, António. "Evaluation of Gold Nanoparticles as Radiosensitizers in Glioblastoma Tumors". Trabalho apresentado em European Radiation Protection Week 2022, Lisbon, 2022.
  3. Paulo, António. "Radiolabeled Gold Nanoseeds containing Substance P Peptides: Synthesis, Characterization and Evaluation in Glioblastoma Cells". Bressanone, 2022.
  4. Paulo, António. "Mitochondrion-Tropic Radioconjugates Carrying TPP and PSMA Derivatives: Radiobiological and Imaging Studies in Prostate Cancer Models". Miami, 2022.
  5. Paulo, António. "Mitochondria-targeted Radiocomplexes for Auger Electron Therapy of Cancer". Grenoble, 2022.
  6. Paulo, António. "“Multifunctional Gold Nanoparticles for Cancer Theranostics”". Coimbra, 2022.
  7. Paulo, António. "Radiolabelled Gold Nanoparticles for image-guided chemoradiotherapy of glioblastoma". Trabalho apresentado em NanoMedicine International Conference 2019, Lisboa, 2019.
  8. Paulo, António; Célia Fernandes; Elisa Palma; Filipa Mendes; do Quental, Leticia; Paula Raposinho; Pedro Vaz; Di Maria, Salvatore. "Radiobiological and Dosimetric Assessment of DNA-Targeted 99mTc(I) Complexes". Trabalho apresentado em NOVA BIOPHYSICA International Congress, Lisboa, 2019.
  9. Paulo, António; J. F. Guerreiro; vitor alves; A.J.Abrunhosa; Octavia M Gil; Filipa Mendes. "New Insights on the radiobiological effects of 64CuCl2- a simple tool for cancer theranostics". Trabalho apresentado em NOVA Biophysica Internacional Conference, Lisboa, 2019.
  10. Zhu, Junjie. "Multifunctional gold nanoparticles for cancer theranostics". Trabalho apresentado em New Challenges in Medical Physics, Coimbra, 2017.
    10.1117/12.2250049
  11. Paulo, António. "Clickable 161Tb-Complexes for DNA-Targeted Radioimmunotherapy". Trabalho apresentado em Cancéropôle Grand Ouest, Nantes, 2016.
    Publicado
  12. Paulo, António. "Radiolabeled Acridine Orange (AO) Derivatives as DNA-Targeted Probes for Auger Therapy". Trabalho apresentado em ICTR-PHE International Conference on Translational Research in Radiation Oncology – Physic for health in Europe, Geneva, 2016.
    Publicado
  13. Paulo, António. "Radiolabeled Peptide-modified Gold Nanoparticles for Cancer Theranostics". Trabalho apresentado em European Molecular Imaging Meeting EMIM 2015, Tübingen, 2015.
    Publicado
  14. Paulo, António. "Bioconjugates for Imaging and Therapy". Trabalho apresentado em COST Action CM1105 WG3 meeting, Warsaw, 2015.
    Publicado
  15. Paulo, António. "Inorganic and Micellar Nanoparticles for the Delivery of Radionuclides". Trabalho apresentado em COST TD1004 Annual Meeting, Belgrade, 2015.
    Aceite para publicação
  16. Paulo, António. "n(II) and Cu(II) Complexes with New Bis(thiosemicarbazone) Derivatives: Preliminary Evaluation of Cytotoxicity and G-quadruplex Binding". Trabalho apresentado em 2nd International Symposium on Functional Metal Complexes that Bind to Biomolecules, Zurich, 2014.
    Publicado
  17. Paulo, António. "Artificial nucleases based on new bipyridine-terpyridine Cu(II) complexes". Trabalho apresentado em 10th Inorganic Chemistry Conference, Costa da CAparica, 2014.
    Publicado
  18. Paulo, António. "Mitochondria-targeted Re(I)/99mTc(I) tricarbonyl complexes". Trabalho apresentado em WG3 meeting – COST CM1105, Barcelona, 2013.
    Publicado
  19. Paulo, António; Paulo, A.. "Design of Radioprobes for Pet and Spect Imaging". Trabalho apresentado em Cardiotecnhix2013 International Congress on Cardiovascular Technologies – Symposium VisualCardio, Vilamoura, 2013.
    Publicado
  20. Paulo, António. "Complexes organométalliques de Téchnetium-99m pour imagerie nucléaire ou radiothérapie ciblée". Trabalho apresentado em JECR - 2012, Sines, 2012.
    Publicado
  21. Paulo, António. "Peptide-based probes for amyloid and cancer imaging". Trabalho apresentado em WG3 meeting – COST TD1004, London, 2012.
    Publicado
  22. Gano, Lurdes; Mendes, Filipa; Fernandes, C.; Paulo, António; Santos, I.. "Biological Evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection". Trabalho apresentado em 15th European Symposium on Radiopharmacy and Radiopharmaceuticals, Edinburgh, 2010.
    Publicado
  23. Paulo, António. "Novel Organometallic Complexes for Multimodal Imaging". Trabalho apresentado em OPIM’08 Hot Topics in Molecular Imaging 2008: Imaging of Nano-objects, Les Houches, 2008.
    Publicado
  24. Paulo, António. "Multifunctional Organometallic Complexes fro Fluorescence and Nuclear Imaging". Trabalho apresentado em 7ª Conferência de Química Inorgânica, Fátima, 2007.
    Publicado
  25. Paulo, António. "An overview of the ITN research on metal-based radioactive probes". Trabalho apresentado em COST D38/WG03/WG05 Meeting, Basel, 2006.
    Aceite para publicação
  26. Paulo, António. "Rhenium(I) carbonyl complexes anchored by soft scorpionates- applications on the development of specific radiopharmaceuticals". Trabalho apresentado em 7th FIGIPS Meeting in Inorganic Chemistry, Lisboa, 2003.
  27. Paulo, António. "New Building Blocks Containing an Unprecedented B-H…M (M = Re, Tc) Agostic interaction for the Labelling of CNS-receptor Ligands". Trabalho apresentado em Conference on Advances and Perspectives in Radiotracer Development (Cost Action B12), Dresden, 2002.
    Publicado
  28. Wilson, I.A.B.; Fleming, K.. "Reactions of Oxo-Complexes of Re(V) with Poly(pyrazolyl)borates". Trabalho apresentado em 3ªConferência de Química Inorgânica da Sociedade Portuguesa de Química, Fátima, 1997.
Tese / Dissertação
  1. Paulo, António. "Poli-hidretos e Oxo-complexos de Rénio com Boratos de Poli(pirazolilo)". Doutoramento, 1998.

Propriedade Intelectual

Patente
  1. Paulo, António. 2013. "Tricarbonyl Complexes with Tridentate Chelators for Myocardium Imaging". Estados Unidos.
  2. Paulo, António. 2007. "Tripodal Ligands with the Coordinating Motifs K2 -BH2 or K3 -BH3 Relevant for Biomedical Applications of Organometallic Complexes".
  3. Paulo, António. 2004. "BIFUNCTIONAL TRIDENTATE PYRAZOLYL CONTAINING LIGANDS FOR RE AND TC TRICARBONYL COMPLEXES".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/11/11 Research on Radiopharmaceutical Sciences at C2TN/IS Seminar in the course "Seminário 1" from the MSc in Biomedical Engineering
ISEL- Instituto Politécnico de Lisboa (Lisboa, Portugal)
2021/01/05 Radiopharmaceutical Chemistry and Radiopharmaceuticals Seminar in the course "Medicinal Inorganic Chemistry" of the MSc in Pharmaceutical Sciences
Universidade Lusófona (Lisboa, Portugal)
2020/12/20 Research on Therapeutic Radiopharmaceuticals On-line Course in “Radiopharmacy”
Associação Portuguesa dos Técnicos de Radiologia, Radioterapia e Medicina Nuclear (ATARP). (Portugal)
2019/12/12 Multifunctional Gold Nanoparticles for Cancer Theranostics New Challenges in Medical Physics
(Coimbra, Portugal)
2019/10/24 Radiolabelled Gold Nanoparticles for Image-guided Chemoradiotherapy of Glioblastoma Multiforme NanoMedicine International Conference 2019
(Lisboa, Portugal)
2019/09/05 New insights on the radiobiological effects of 64CuCl2 - a simple tool for prostate cancer theranostics NOVA Biophysica Internacional Conference
(Lisboa, Portugal)
2019/09/05 Radiobiological and Dosimetric Assessment of DNA-Targeted 99mTc(I) Complexes NOVA BIOPHYSICA International Congress
(Lisboa, Portugal)
2019/08/23 Multifunctional Radioconjugates for Cell-Specific DNA-Targeting with Auger Electron Emitters The 9th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes
(oxford, Reino Unido)
2019/07/03 Technetium(I) Organometallic Complexes for Cardiovascular Imaging and Cancer Theranostics METALS IN THERAPY AND DIAGNOSIS - A MetalBIO Workshop
(Lugo, Espanha)
2019/05/27 Assessment of the Energy Deposited and Biological Damage Induced by DNA-targeted 99mTc-complexes 3rd International Conference on Dosimetry and its Applications
(Lisboa, Portugal)
2018 Multifunctional Bioconjugated Gold Nanoparticles for Cancer Theranostics Fourth International Conference on Precision Image-Guided Small Animal Radiotherapy Research
(Lisboa, Portugal)
2015/10 Biological assessment of radiolabelled gold nanoparticles for in vivo targeting of GRPr expressing tumours Workshop New Advances in animal models and preclinical imaging for translational research in cancerology
(La Turballe, França)
2015/02/15 Radiolabeled Acridine Orange (AO) Derivatives as DNA-Targeted Probes for Auger Therapy ICTR-PHE International Conference on Translational Research in Radiation Oncology – Physic for health in Europe
(Geneva, Suiça)
2013/11/20 Small Core Gold Nanoparticles Stabilized by Thiolated DOTA Derivatives Meeting “Nanoparticles for early Diagnostics of inflammatory diseases”
(Lisboa, Portugal)
2013/09/21 Perfusion and specific radioprobes for cardiac imaging Cardiotecnhix 2013 International Congress on Cardiovascular Technologies – Symposium VisualCardio
(Vilamoura, Portugal)
2013/09/21 Design of Radioprobes for PET and SPECT imaging Cardiotecnhix 2013 International Congress on Cardiovascular Technologies – Symposium VisualCardio
(Vilamoura, Portugal)
2010/04 Biological evaluation of novel 99mTc(I) cationic complexes as probes for tumoral detection ESRR’10
(Edimburgh, Reino Unido)
2010/02/11 New [99mTc(CO)3]+-labeled Bombesin Conjugates Bearing an Acridine Orange Moiety for Diagnosis and/or Therapy of Cancer EPI XII- Iberian Peptide Meeting
(Lisboa, Portugal)
2008/02/05 Novel Organometallic Complexes for Multimodal Imaging TOPIM’08 Hot Topics in Molecular Imaging 2008: Imaging of Nano-objects
(Les Houches, França)
2007/11/30 Multifunctional Organometallic Complexes for Fluorescence and Nuclear Imaging 7ª Conferência de Química Inorgânica
(Portugal)
2003/06 Rhenium(I) carbonyl complexes anchored by soft scorpionates – applications on the development of specific radiopharmaceuticals 7th FIGIPS Meeting in Inorganic Chemistry
(Lisboa, Portugal)
1999/03 Re(V) Oxocomplexes with Dihydobis(pyrazolyl)borates IV Conferência de Química Inorgânica da Sociedade Portuguesa de Química
(Peniche, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/11/01 - Atual EGFR/SHP2-targeted nanomedicines for colorectal cancer theranostic
Coorientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/09/01 - Atual Subcellular Targeted Radiopharmaceuticals to Unravel the Potential of Auger-Electron Cancer Therapy
Orientador de Catarina Dorisa Azevedo da Silva
 Engenharia Biomédica (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09/01 - Atual Organelle-targeted Radioconjugates for Auger Therapy of Cancer: Biochemical and Biological Characterization of their "Cold" Surrogates¿
Coorientador
 Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/10/01 - Atual Modeling radiobiological effects of nanoparticles in proton therapy of glioblastomas
Coorientador
 Engenharia Biomédica e Biofísica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/03/01 - 2021/10/31 Mitochondria-Targeted 111In-Radiocomplexes for Auger Therapy of Prostate Cancer
Orientador
 Bioengenharia e Nanossistemas (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/02/01 - 2020/06/30 Evaluation of the Radiosensitizing Capabilities of Target-Specific Gold Nanoparticles (AuNPs) in the Radiotherapy of Glioblastoma
Orientador
 Energy and Nuclear Engineering (Mestrado)
Politecnico di Torino, Itália
2015 - 2020 Clickable Radiocomplexes for Cancer Theranostics
Orientador
 Chemistry (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2019 Bimodal Probes for Imaging of Prostate Cancer
Orientador
 Química Farmacêutica e Terapêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2019 Multifunctional Gold Nanoparticles for Cancer Theranostics/Post-doctoral research work
Orientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2012 - 2018 Bis(thiosemicarbazone) Cu(II) Complexes as Selective G-quadrupex Ligands: Application in the Design of Anticancer Drugs/Post-doctoral research work
Orientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2013 - 2017 Obtenção de complexos de GaIII e InIII com interesse em medicina nuclear a partir do desenvolvimento de partir do desenvolvimento de ligantes multidentados
Coorientador
 Chemistry (Doutoramento)
Universidade de São Paulo Instituto de Química de São Carlos, Brasil
2015 - 2016 Complexos de cobre dirigidos a G-quadruplexos para teranóstica de cancro
Orientador
 Química Farmacêutica e Terapêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Complexos de Gálio e Índio com Ligantes Bioativos como Modelos para Terapia de Câncer e Medicina Nuclear/Post-doctoral research work
Orientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2014 - 2015 Compostos Radioiodados para Terapia Auger
Orientador
 Química Bioorgânica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2015 Molecular and Nano Tools for Cancer Theranostics (EXCL/QEQ-MED/0233/2012)
Orientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2008 - 2015 New Vanadium and Copper Complexes with Relevance as Antidiabetic and/or anticancer drugs/Post-doctoral research work
Orientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2013 - 2014 Multifunctional Organometallic Compounds for Auger Therapy
Orientador
 Bioquímica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2014 Targeting telomerase inhibition with new anti-tumoral Cu(II) complexes (PTDC/QUI-QUI/114139/2009)
Coorientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2009 - 2014 Targeted Nanoradiopharmaceuticals for Cancer Diagnosis and/or Therapy: Synthesis, Characterization and Biological Evaluation
Orientador
 Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/10 - 2013/06 Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation" ( PTDC/QUI-QUI/102049/2008)
Orientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2012 - 2013 Phytochemicals agents as sensitizers in Radio-Therapy in Nuclear Medicine
Orientador
 Medicina Nuclear (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012 - 2013 Fracionamento de kits de HMDP para marcação com 99mTc – Influência da temperatura e da idade das fracções Medicina Nuclear (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011/06 - 2011/12 Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation (PTDC/QUI-QUI/102049/2008)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2007 - 2011 Complexos Organometálicos de Tc(I)/Re(I) para Imagiologia Molecular de Tecidos Neoplásicos
Orientador
 Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2008 Ga(III) and Re(V) complexes with Asymmetric (N2O) Donor Ligands with Relevance for the Design of Antitumor Drugs and/or Radiopharmaceuticals Química Inorgânica Biomédica: Aplicações em Diagnóstico e Terapia (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2006 - 2007 M(I) and M(V) (M = Re, 99mTc) Complexes with Pyrazole-based Ligands for the Design of Specific Radiopharmaceuticals
Orientador
 Química Inorgânica Biomédica: Aplicações em Diagnóstico e Terapia (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2005 - 2007 Novel Radioactive Probes for Molecular Imaging of Sigma Receptors" (POCI/QUI/59588/2004)
Orientador
2003 - 2007 Molecular Probes for an early diagnostic of Alzheimer disease/Post-doctoral research work
Orientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2002 - 2007 Complexos de Rénio e Tecnécio com Ligandos N-heterocíclicos Dirigidos ao Núcleo de Células Tumorais: da Imagiologia Molecular À Radioterapia com 99m Tc
Orientador
 Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2006/05 - 2006/12 Multicomponent Technetium and Gallium metallointercalators for targeted radiotherapy" (POCI/QUI/57632/2004)
Orientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2001 - 2005 Rhenium and Technetium-99m Complexes with Sulfur Donor Scorpionates - Application in the Design of Radiopharmaceuticals for the targeting of Brain Receptors
Orientador
 Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2002 - 2002 Macrocyclic Re and 99mTc Complexes Relevant for Selective Radiotherapy
Orientador
 Química + Química Tecnológica (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal
2000 - 2001 Re and Tc Complexes for Central Nervous System/Post-doctoral research work
Coorientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
1999 - 2001 Rhenium Complexes with Nitrogen Donor Ligands: Synthesis, Characterization and Catalytic Studies (POCI/QUI/59588/2004)
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
1996 - 1997 Synthesis, Characterization and Reactivity Studies of Rhenium Complexes with the [ReN]2+ e [Re=O]3+ Units/post-doctoral research work
Coorientador
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
1995 - 1995 Synthesis of Re(V) glycolates from Re(VII) oxides Química + Química Tecnológica
Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/11/27 - 2023/11/29 6th Meeting of the PRISMAP project including the workshop "Challenges in nuclear medicine" hold at the Faculty of Medicine (Universidade de Lisboa) (2023/11/27 - 2023/11/29)
Encontro (Presidente da Comissão Organizadora)
 Associação para o Desenvolvimento do Instituto Superior Técnico, Portugal
2023/09/11 - 2023/09/15 PRISMAP TRAINING COURSE ON: RADIOPHARMACEUTICAL SCIENCE - FROM RADIOCHEMISTRY TO PRECLINICAL STUDIES (2023/09/11 - 2023/09/15)
Outro (Presidente da Comissão Organizadora)
 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2023/07/17 - 2023/07/21 Hands-on Training (HoT) on the "Synthesis and Analytical Control of Radiopharmaceuticals" (under the framework of the European project A-CINCH) (2023/07/17 - 2023/07/21)
Outro (Presidente da Comissão Organizadora)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/06/04 - 2018/06/08 Medicis-Promed Summer School (2018/06/04 - 2018/06/08)
Oficina (workshop) (Presidente da Comissão Organizadora)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/10/17 - 2017/10/17 Workshop on "Preclinical small animal in vivo imaging" (2017/10/17 - 2017/10/17)
Oficina (workshop) (Presidente da Comissão Organizadora)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/12/05 - 2016/12/06 Workshop "Nuclear Molecular Imaging¿" (2016/12/05 - 2016/12/06)
Oficina (workshop) (Presidente da Comissão Organizadora)
 International Atomic Energy Agency, Áustria
2015/10/05 - 2015/10/05 Final meeting of the WG2 of the COST Action CM1105 (Functional metal complexes that bind to biomolecules) (2015/10/05 - 2015/10/05)
Encontro (Presidente da Comissão Organizadora)
 Centro de Ciências e Tecnologias Nucleares, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019 “Production and Purification of Radiometals for Theranostics via Liquid Targets in a Medical Cyclotron”
Arguente principal
 Vítor Alves (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 Bimodal Probes for Imaging of Prostate Cancer
Orientador
 Sofia Batanete (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 Avaliação da atividade anticancerígena de aptameros de DNA para terapia do cancro do colo do útero
Arguente principal
 Márcia Filipa Pinto Ribeiro (Mestrado)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2018 Avaliação da atividade anticancerígena de aptameros de DNA para terapia do cancro do colo do útero
Arguente
 Márcia Filipa Pinto Ribeiro (Mestrado)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2017 Diseño y síntesis de compuestos de coordinación con afinidad por acúmulos de ß-amiloide.
Arguente principal
 Arantxa Pino Cuevas (Doutoramento)
Universidade de Vigo Facultad de Ciencias, Espanha
2016 Complexos de cobre dirigidos a G-quadruplexos para teranóstica de cancro
Orientador
 Raquel Correia (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 Compostos Radioiodados para Terapia Auger
Orientador
 Edgar Pereira (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 Nanocápsulas dirigidas al sistema linfático: Una aproximación al tratamiento del cáncer metastásico
Arguente principal
 Raquel Abellán Pose (Doutoramento)
Universidade de Santiago de Compostela Facultad de Farmacia, Espanha
2014 “Optimized molecular imaging agents: from metal chelates to micelles to gold nanoparticles”
Arguente principal
 Miguel Ferreira (Doutoramento)
Universidade do Minho Departamento de Química, Portugal
2014 Targeted Nanoradiopharmaceuticals for Cancer Diagnosis and/or Therapy: Synthesis, Characterization and Biological Evaluation
Orientador
 Francisco Silva (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 Multifunctional Organometallic Compounds for Auger Therapy
Orientador
 Annica Rosa (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 Organometallic complexes of Tc(I) and Re(I) for radiometalation of biologically active peptides
Vogal
 Mariana Nogueira Pinto (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 Avaliação biológica de complexos catiónicos de 99mTc(I) como sondas para detecção tumoral e monitorização funcional de resistência a múltiplos fármacos
Arguente principal
 Fernando Toscano (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 Phytochemicals agents as sensitizers in Radio-Therapy in Nuclear Medicine
Orientador
 Nuno Lemos (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2013 Fraccionamento de kits de HMDP para marcação com 99mTc – Influência da temperatura e da idade das fracções
Orientador
 Vanessa Santos (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2012 Complexos Organometálicos de Tc(I)/Re(I) para Imagiologia Molecular de Tecidos Neoplásicos
Orientador
 Carolina Candeias de Moura (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 Síntese de novos compostos organometálicos de Fe(II): estudos das suas potencialidades como agentes anticancerígenos
Arguente principal
 Ana Cristina Teixeira Martins Gonçalves (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 Activação de alcinos por complexos de Pd (II) ou Pt (II) com ligandos derivados da cânfora
Arguente
 Ana Sofia Diogo Ferreira (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 Complexos de iões metálicos com interesse na terapia do cancro: estudos de interacção com biomoléculas
Arguente principal
 Filipa Pedro Costa Santos (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 Complexos de Re e Tc e compostos iodados relevantes para a concepção de radiofármacos
Arguente
 Célia Fernandes (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 Complexos de Rénio e Tecnécio com Ligandos N-heterocíclicos Dirigidos ao Núcleo de Células Tumorais: da Imagiologia Molecular à Radioterapia com 99mTc
Orientador
 Rute Vitor (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2008 Complexos de Ga(III) e de Re(V) com Ligandos Assimétricos Doadores (N2O) com Interesse para Desenvolvimento de Agentes Antitumorais e/ou de Radiofármacos
Orientador
 Francisco Silva (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 Complexos de M(I) e M(V) (M = Re, 99mTc) com Ligandos do Tipo Pirazolo Relevantes para o Desenvolvimento de Radiofármacos Específicos
Orientador
 Carolina Moura (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2006 Rhenium and Technetium-99m Complexes with Sulfur Donor Scorpionates-Application in the Design of Radiopharmaceuticals for the Targeting of Brain Receptors
Orientador
 Raquel Garcia (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2004 Complexos Organometálicos Potencialmente Úteis para o Desenvolvimento de Radiofármacos para a Detecção do Melanoma
Vogal
 Rita Oliveira (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2022 - Atual Member of the editorial board of "Frontiers in Nuclear Medicine" Frontiers
2021 - Atual Editor of the special issue "New Advances in Radiopharmaceutical Sciences: Chemistry and Applications" in "Molecules"Molecules MDPI
2021 - Atual Editor of the special issue "Radiolabeled nanoparticles in nuclear medicine" in "Frontiers in Nuclear Medicine" Frontiers
2020 - Atual Inorganic and Nano-metal Chemistry Taylor & Francis
2019 - 2020 Editor of the special issue "Targeted Drug Delivery" in "Materials" MDPI
2018 - 2018 Editor of the special issue "Metal Complexes for Imaging and Therapy" in "Inorganics" MDPI

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2022/09/05 - 2022/09/09 Technical Meeting on "Auger Electron Emitters for Radiopharmaceutical Developments", Vienna International Centre Vienna, Austria International Atomic Energy Agency, Áustria
2021/11/15 - 2021/11/19 Technical Meeting on "The Preclinical Testing of Radiopharmaceuticals", Coimbra, Portugal 5-19 November 2021 International Atomic Energy Agency, Áustria

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2001 - 2022 Radiofarmácia-I Imagem Médica e Radioterapia (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2001 - 2022 Radiofarmácia II Imagem Médica e Radioterapia (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2020 - 2021 Radioquímica Proteção e Segurança Radiológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2019 Química Biológica Química Medicinal (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2015 Química Farmacêutica Química Farmacêutica e Terapêutica (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012 Radioquímica Química Inorgânica Biomédica: Aplicações em Diagnóstico e Terapia (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2012 Química Inorgânica Médica Química Inorgânica Biomédica: Aplicações em Diagnóstico e Terapia (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2003/01/27 Interview published in Diário de Notícias ("A vehicle on the way to the mysteries of the brain") to promote the FCT project POCTI/QUI/42939/2001) Diário de Notícias

Membro de associação

Nome da associação Tipo de participação
2020 - Atual European Network on Nuclear and Radiochemistry Education and Training National Delegate

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020 - Atual National delegate of the management committee of the COST Action CA19114 (“Network for Optimized Astatine labeled Radiopharmaceuticals”)
Membro
 European Cooperation in Science and Technology, Bélgica
2017 - Atual Member of the management committee of the MEDICIS project from CERN
Membro
 European Organization for Nuclear Research, Suiça
2015 - Atual Member of the Coordinating Commission of the Scientific Council of C2TN/IST
Membro
 Centro de Ciências e Tecnologias Nucleares, Portugal
2015 - 2018 Member of the Executive Committee of the Department of Nuclear Sciences and Engineering from IST/Universidade de Lisboa
Membro
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2016 National delegate of the management committee of the COST Action CM1105 (“Functional metal complexes that bind to biomolecule”) European Cooperation in Science and Technology, Bélgica
2011 - 2015 National delegate of the management committee of the COST Action TD1007 (“Bimodal PET-MRI molecular imaging technologies and applications for in vivo monitoring of disease and biological processes”)
Membro
 European Cooperation in Science and Technology, Bélgica
2011 - 2012 Member of the scientific committee of ICNAS/University of Coimbra
Membro
 Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2020 - 2020 Member of the jury for the recruitment of an Auxiliary Professor (scientific area of nuclear medicine) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2019 - 2019 “NATIONAL COMPETITION FOR 2020 REGULAR FONDECYT PROJECTS”
2019 - 2019 Member of the jury for the recruitment of an Auxiliary Professor (scientific area of nuclear medicine) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2019 - 2019 Member of the jury for the recruitment of a Principal Researcher (scientific area of Radiochemistry/Radiopharmacy) Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2017 - 2018 FCT calls for PhD grants, Chemistry Panel
2013 - 2013 Member of the jury for the recruitment of an Auxiliary Researcher (scientific area of Radiochemistry/Radiopharmacy) Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2013 - 2013 Member of the jury for the recruitment of an Auxiliary Professor (scientific area of Nuclear Medicine) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2010 - 2010 Call 2010 of Rhône-Alpes region for scientific projects Région Auvergne-Rhône-Alpes, França