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Manuela Carvalheiro graduated in Applied Chemistry/Biotechnology in 1991 (FCT, UNL), obtained her M.S. in Food Technology in 2001 (FCT, UNL) and completed her PhD in Pharmaceutical Technology in 2011 at the Faculty of Pharmacy, University of Lisbon. Is currently Research Assistant in the Department of Pharmacy, Pharmacology and Health Technologies at the Faculty of Pharmacy, University of Lisbon, and member of the Research Institute for Medicines (iMed.ULisboa). The scientific research area of expertise involves the design, development, and biological evaluation of Nanoparticulate Lipid-Based systems for the delivery of new chemical entities, already established chemotherapeutics and genetic drugs. The aim is to increase the therapeutic efficacy of the loaded drug, reduce their toxicity, and allow drug release at the specific site in a controlled manner. Research activity has been dedicated to the development and optimization of cost-effective lipid-based nanocarriers (liposomes, ethosomes, ultra-deformable vesicles, SLN, NLC), for selective intracellular macrophage delivery of active drugs for the treatment of Leishmania related infections exploring non-invasive routes of administration. Her work also includes the optimization of cells-based in vitro assays to assess the performance of colloidal systems in mammalian cells (cytotoxicity and internalization studies) and Leishmania parasites (susceptibility analysis of drug formulation) and establishment of animal models of human diseases for assessment of in vivo efficacy and safety. In the last few years she has been working towards the valorization of agri-food by-products through their incorporation in dermal formulations. More recently she has been involved in the establishment and optimization of a mice model of breast cancer brain metastasis for the evaluation of therapeutic efficacy of new drug candidates. She has experience in coordinating research projects as a principal investigator and participates as a researcher in several funded projects. She has supervised PhD student, MSc students, Erasmus fellow and several undergraduate students in research work. Reviewer in international peer review journals.
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Identificação

Identificação pessoal

Nome completo
Manuela Colla Carvalheiro

Nomes de citação

  • Carvalheiro, Manuela
  • Carvalheiro, Manuela C
  • Carvalheiro, Manuela Colla

Identificadores de autor

Ciência ID
C415-C96F-C9FC
ORCID iD
0000-0002-6028-4717
Researcher Id
M-5581-2014
Scopus Author Id
57202998389

Endereços de correio eletrónico

  • mcarvalheiro@ff.ulisboa.pt (Profissional)

Telefones

Telefone
  • 217946404 Ext.: 14772 (Profissional)

Websites

  • http://www.imed.ulisboa.pt/; http://www.ff.ulisboa.pt/ (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Italiano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2011
Concluído
 Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Liposomes as Nanosystems for the transport and Delivery of Bioactive Agents" (TESE/DISSERTAÇÃO)
 Distinção e Luovor
2001
Concluído
 Tecnologia Alimentar / Qualidade (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Ocorrência e Distribuição de Leveduras de Contaminação Alimentar. Identificação e Caracterização Molecular." (TESE/DISSERTAÇÃO)
 Bom com Distinção
1991
Concluído
 Química Aplicada - Biotecnologia (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/03/25 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2009/01/01 - 2011/03/24 Assistente de Investigação (carreira) (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2001/06/01 - 2008/12/31 Contrato Administrativo de Provimento Assistente de Investigação - Carreira de Investigação Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal
1999/06/30 - 2001/05/31 Contrato de trabalho a termo certo Estagiário de Investigação _ Carreira de Investigação Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal
1998/06/01 - 1999/06/29 Contrato de Técnico Superior de 2ª classe – Carreira Técnica Superior Instituto Nacional de Engenharia, Tecnologia e Inovação, Portugal
1995/01/01 - 1998/05/31 Grant - junior researcher Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal
1992/11/01 - 1994/11/01 Master student Fundação para a Ciência e a Tecnologia, Portugal
1991/02/01 - 1992/10/01 Grant student in PEDIP JTI program Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal
Projetos

Projeto

Designação Financiadores
2021 - 2024 Targeting TLR2 for improved veterinary vaccines
PTDC/CVT-CVT/4599/2021
 Fundação para a Ciência e a Tecnologia
2021/01/10 - 2023/06 Detect, prevent, eradicate: a multi-step strategy to abrogate brain metastasization of breast cancer
FCT-PTDC/MED-ONC/29402/2017
Co-orientador de aluno de PhD que desenvolveu o trabalho experimental para a obtenção do grau no âmbito deste projeto
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2021 - 2023 Tackling trypanosomiasis cardiomyopathy with microRNAs and tridimensional (3D) cell models
EXPL/CVT-CVT/0175/2021
 Fundação para a Ciência e a Tecnologia
2018 - 2022 Sustainable, Safe, and Scalable (3S) approach for lycopene valorization: driving the knowledge toward an academia-industry interface for topical treatment of inflammation
PTDC/SAU-SER/30197/2017
Investigador
Fundação para a Ciência e a Tecnologia
2018 - 2022 Phage-Enzybiotic : dealing with critical pathogenic antibiotic-resistant bacteria
PTDC/BTM-SAL/28978/2017
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2022 Programming the type and localization of adaptive immunity by targeting TLR2: a strategy for the development of novel veterinary vaccines
C493040443-00089191
PTDC/CVT-CVT/31840/2017
Investigador
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Em curso
2016 - 2020 VIH_TRANFERSOME: Inibidor de fusão veiculado em Transfersomas para libertação transdérmica
PGG/006/2016
Investigador
Gilead Génese, Portugal
 Gilead Génese
Concluído
2017/09 - 2019/09 Targeted liposomal antioxidant and anti-inflammatory therapy for liver ischemic reperfusion injury
Farm-ID 200009
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Phospholipid Forschungszentrum e V
2013 - 2015 Priming of Mesenchymal Stromal Cells from the Umbilical Cord Tissue (UC X®) as a Means of Incrementing Their Therapeutic Potency for Rheumatoid Arthritis
EXPL/DTP-FTO/0308/2013
 Fundação para a Ciência e a Tecnologia
2013/07 - 2014/12 Cutaneous leishmaniasis: an innovative idea to explore the topical treatment of skin lesions
EXPL/CVT-EPI/0862/2012
Investigador responsável
Fundação para a Ciência e a Tecnologia
2012 - 2014 Helicobacter pylori phages: translating an underestimated phenomenon into a therapeutic application
PTDC/EBB-EBI/119860/2010
 Fundação para a Ciência e a Tecnologia
2010 - 2012 Development of new polymer-liposome complexes combining experimental and computational approaches
PTDC/EQU-EPR/099226/2008
 Fundação para a Ciência e a Tecnologia
2010 - 2012 A challenge for the treatment of parasitic diseases: rational design of Trifluralin derivatives and appropriate nanoformulations
PTDC/CVT/098290/2008
 Fundação para a Ciência e a Tecnologia
2005 - 2008 Microtubule Inhibitor Formulations Against Zoonotic Visceral Leishmaniasis
POCI/CVT/56995/2004
 Fundação para a Ciência e a Tecnologia
2003 - 2006 Targeted Antisense Therapy: A Novel Approach for the Treatment of Human Small Cell Lung Cancer
POCTI/FCB/48487/2002
 Fundação para a Ciência e a Tecnologia
2002 - 2005 Liposomal Formulations of Dinitroanilines for the Treatment of Canine Leishmaniasis.
POCTI/2000/FCB/35249
 Fundação para a Ciência e a Tecnologia
1999 - 2000 SUBERIMUNE_Synthesis of adjuvants for vaccines obtained from wastes of beer and cork industries.
LP089-P31B-05/97
 Agência Nacional de Inovação SA
1997 - 2000 Chemically modified immunomodulators associated to colloidal carriers for cancer therapy
Praxis XXI Ref. 2/2.1/SAU/1381/95,
 Fundação para a Ciência e a Tecnologia
1995 - 2000 Liposome-Encapsulated Drugs for the Therapy of Leishmanial Infections
Science for Stability PO-INFECTION 941457
 NATO
1993 - 1996 Bioconjugados e Vectores para Fins Terapêuticos
PBIC/C/SAU/1551/92
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em jornal
  1. Carvalheiro, Manuela; Faria-Silva, Ana Catarina; Simões P; Bellofatto M; Mota J. "Eco-extracted a-Tomatine as an Antioxidant for Natural Soap", Cosmetics & Toiletries, 2023
Artigo em revista
  1. Joana Godinho-Pereira; Daniela Vaz; Inês Figueira; Joana Aniceto-Romão; Istvan Krizbai; Rui Malhó; João Rocha; et al. "Breast Cancer Brain Metastases: Implementation and Characterization of a Mouse Model Relying on Malignant Cells Inoculation in the Carotid Artery". Cells (2023): https://doi.org/10.3390/cells12162076.
    10.3390/cells12162076
  2. Juliana Inês Weber; Armanda Viana Rodrigues; Ana Valério-Bolas; Telmo Nunes; Manuela Carvalheiro; Wilson Antunes; Graça Alexandre-Pires; Isabel Pereira da Fonseca; Gabriela Santos-Gomes. "Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis". Cells (2023): https://doi.org/10.3390/cells12081101.
    10.3390/cells12081101
  3. Diana Morais; Luís Tanoeiro; Andreia Marques; Tiago Gonçalves; Aida Duarte; António Matos; Joana Vital; et al. "Liposomal Delivery of Newly Identified Prophage Lysins in a Pseudomonas aeruginosa Model". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms231710143.
    10.3390/ijms231710143
  4. Carvalheiro, Manuela; Ferreira-Silva, Margarida; Holovanchuk, Denys; H. Susana Marinho; Moreira, João Nuno; Soares, Helena; Corvo, Maria Luisa ; Cruz, M Eugénia M. Autor correspondente: Carvalheiro, Manuela. "Antagonist G-targeted liposomes for improved delivery of anticancer drugs in small cell lung carcinoma". International Journal of Pharmaceutics 612 (2022): 121380-121380. http://dx.doi.org/10.1016/j.ijpharm.2021.121380.
    10.1016/j.ijpharm.2021.121380
  5. Margarida Ferreira-Silva; Ana Catarina Faria da Silva Severiano; Manuela Carvalheiro; Sandra Simões; H. Susana Marinho; Paulo Marcelino; Maria Celeste Campos; et al. "Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/1/104.
    10.3390/pharmaceutics14010104
  6. Mikel Etxebeste-Mitxeltorena; Esther Moreno; Manuela Carvalheiro; Alba Calvo; Iñigo Navarro-Blasco; Elena González-Peñas; José I. Álvarez-Galindo; et al. "Oral Efficacy of a Diselenide Compound Loaded in Nanostructured Lipid Carriers in a Murine Model of Visceral Leishmaniasis". ACS Infectious Diseases 7 12 (2021): 3197-3209. https://doi.org/10.1021/acsinfecdis.1c00394.
    10.1021/acsinfecdis.1c00394
  7. Carla Varrica; Manuela Carvalheiro; Catarina Faria-Silva; Carla Eleutério; Giuseppina Sandri; Sandra Simões. "Topical Allopurinol-Loaded Nanostructured Lipid Carriers: A Novel Approach for Wound Healing Management". Bioengineering (2021): https://doi.org/10.3390/bioengineering8120192.
    10.3390/bioengineering8120192
  8. Luciana F. C. Girão; Manuela Colla Carvalheiro; Margarida Ferreira-Silva; Surza L. G. da Rocha; Jonas Perales; M. Bárbara F. Martins; Maria Antonieta Ferrara; Elba P. S. Bon; M. Luísa Corvo. "ASP-Enzymosomes with Saccharomyces cerevisiae Asparaginase II Expressed in Pichia pastoris: Formulation Design and In Vitro Studies of a Potential Antileukemic Drug". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222011120.
    10.3390/ijms222011120
  9. Rita F. Cunha; Sandra Simões; Manuela Carvalheiro; José M. Azevedo Pereira; Quirina Costa; Andreia Ascenso. "Novel Antiretroviral Therapeutic Strategies for HIV". Molecules 26 17 (2021): 5305-5305. https://doi.org/10.3390/molecules26175305.
    10.3390/molecules26175305
  10. Maria Quitério; Sandra Simões; Andreia Ascenso; Manuela Carvalheiro; Ana Paula Leandro; Isabel Correia; Ana Silveira Viana; et al. "Development of a Topical Insulin Polymeric Nanoformulation for Skin Burn Regeneration: An Experimental Approach". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22084087.
    10.3390/ijms22084087
  11. Mehdi Sagha Kahvaz; Shahrzad Soltani; Sheyda Soltani; Manuela Colla Carvalheiro; Masoud Foroutan. "Low Serum Levels of Selenium, Zinc, Iron, and Zinc/Copper Ratio in an Endemic Region of Cutaneous Leishmaniasis in Southwest Iran". Biological Trace Element Research (2021): https://doi.org/10.1007/s12011-020-02271-z.
    10.1007/s12011-020-02271-z
  12. Carvalheiro, Manuela; Vieira, Jennifer; Faria-Silva, Catarina; Marto, Joana; Simões, Sandra. "Amphotericin B-loaded deformable lipid vesicles for topical treatment of cutaneous leishmaniasis skin lesions". Drug Delivery and Translational Research (2021): http://dx.doi.org/10.1007/s13346-021-00910-z.
    10.1007/s13346-021-00910-z
  13. Varrica, Carla; Dias, Helena Sofia; Reis, Catarina; Carvalheiro, Manuela; Simões, Sandra. "Targeted delivery in scleroderma fibrosis". Autoimmunity Reviews 20 2 (2021): 102730. http://dx.doi.org/10.1016/j.autrev.2020.102730.
    10.1016/j.autrev.2020.102730
  14. Pinto, Luciana Matos Alves; Adeoye, Oluwatomide; Thomasi, Sérgio Scherrer; Francisco, Ana Paula; Carvalheiro, Manuela Colla; Cabral-Marques, Helena. "Preparation and characterization of a synthetic curcumin analog inclusion complex and preliminary evaluation of in vitro antileishmanial activity". International Journal of Pharmaceutics 589 (2020): 119764. http://dx.doi.org/10.1016/j.ijpharm.2020.119764.
    10.1016/j.ijpharm.2020.119764
  15. Mota, Ana Henriques; Andrade, Joana M.; Rodrigues, Maria João; Custódio, Luísa; Bronze, Maria Rosário; Duarte, Noélia; Baby, André; et al. "Synchronous insight of in vitro and in vivo biological activities of Sambucus nigra L. extracts for industrial uses". Industrial Crops and Products 154 (2020): 112709. http://dx.doi.org/10.1016/j.indcrop.2020.112709.
    Publicado • 10.1016/j.indcrop.2020.112709
  16. Faria-Silva, Catarina; Ascenso, Andreia; Costa, Ana M.; Marto, Joana; Carvalheiro, Manuela; Ribeiro, Helena Margarida; Simões, Sandra. "Feeding the skin: A new trend in food and cosmetics convergence". Trends in Food Science & Technology 95 (2020): 21-32. http://dx.doi.org/10.1016/j.tifs.2019.11.015.
    Publicado • 10.1016/j.tifs.2019.11.015
  17. Pedrosa, Pedro; Corvo, M. Luísa; Ferreira-Silva, Margarida; Martins, Pedro; Carvalheiro, Manuela Colla; Costa, Pedro M.; Martins, Carla; et al. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles". International Journal of Molecular Sciences 20 21 (2019): 5510. http://dx.doi.org/10.3390/ijms20215510.
    Acesso aberto • 10.3390/ijms20215510
  18. Miranda, Joana P.; Camões, Sérgio P.; Gaspar, Maria M.; Rodrigues, Joana S.; Carvalheiro, Manuela; Bárcia, Rita N.; Cruz, Pedro; et al. "The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.00018.
    10.3389/fimmu.2019.00018
  19. Pedro Pedrosa; Maria Luísa Corvo; Margarida Ferreira-Silva; Pedro Martins; Manuela Carvalheiro; Pedro Costa; Carla Martins; et al. "Targeting cancer resistance via multifunctional gold-nanoparticles: Cetuximab for improving delivery". Scientific Reports (2019): https://www.mdpi.com/1422-0067/20/21/5510.
    Publicado • 10.3390/ijms20215510.
  20. Menezes, A.C.; Carvalheiro, M.; Ferreira de Oliveira, J.M.P.; Ascenso, A.; Oliveira, H.. "Cytotoxic effect of the serotonergic drug 1-(1-Naphthyl)piperazine against melanoma cells". Toxicology in Vitro 47 (2018): 72-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034571213&partnerID=MN8TOARS.
    10.1016/j.tiv.2017.11.011
  21. Raposo, L.R.; Roma-Rodrigues, C.; Faísca, P.; Alves, M.; Henriques, J.; Carvalheiro, M.C.; Corvo, M.L.; et al. "Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT". Veterinary and Comparative Oncology 15 3 (2017): 952-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964950972&partnerID=MN8TOARS.
    10.1111/vco.12235
  22. Bárcia, R.N.; Santos, J.M.; Teixeira, M.; Filipe, M.; Pereira, A.R.S.; Ministro, A.; Água-Doce, A.; et al. "Umbilical cord tissue–derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing". Cytotherapy 19 3 (2017): 360-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009396582&partnerID=MN8TOARS.
    10.1016/j.jcyt.2016.11.008
  23. Fernandes, A.R.; Jesus, J.; Martins, P.; Figueiredo, S.; Rosa, D.; Martins, L.M.R.D.R.S.; Corvo, M.L.; et al. "Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents". Journal of Controlled Release 245 (2017): 52-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999008906&partnerID=MN8TOARS.
    10.1016/j.jconrel.2016.11.021
  24. Simões, M.G.; Alves, P.; Carvalheiro, M.; Simões, P.N.. "Stability effect of cholesterol-poly(acrylic acid) in a stimuli-responsive polymer-liposome complex obtained from soybean lecithin for controlled drug delivery". Colloids and Surfaces B: Biointerfaces 152 (2017): 103-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009212421&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.01.002
  25. Lopes, Rui M; Pereira, Joana; Esteves, M Alexandra; Gaspar, M Manuela; Carvalheiro, Manuela; Eleutério, Carla V; Gonçalves, Lídia; et al. "Lipid-based nanoformulations of trifluralin analogs in the management of Leishmania infantum infections". Nanomedicine 11 2 (2016): 153-170. http://dx.doi.org/10.2217/nnm.15.190.
    10.2217/nnm.15.190
  26. Simões, S.; Carvalheiro, M.; Gaspar, M.M.. "Lipid-based nanocarriers for cutaneous leishmaniais and buruli ulcer management". Current Pharmaceutical Design 22 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85010671889&partnerID=MN8TOARS.
    10.2174/1381612822666160701083812
  27. Carvalheiro, M.; Esteves, M.A.; Santos-Mateus, D.; Lopes, R.M.; Rodrigues, M.A.; Eleutério, C.V.; Scoulica, E.; Santos-Gomes, G.; Cruz, M.E.M.. "Hemisynthetic trifluralin analogues incorporated in liposomes for the treatment of leishmanial infections". European Journal of Pharmaceutics and Biopharmaceutics 93 (2015): 346-352. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930212963&partnerID=MN8TOARS.
    10.1016/j.ejpb.2015.04.018
  28. Lopes, R.M.; Gaspar, M.M.; Pereira, J.; Eleutério, C.V.; Carvalheiro, M.; Almeida, A.J.; Cruz, M.E.M.. "Liposomes versus Lipid Nanoparticles: Comparative Study of Lipid-Based Systems as Oryzalin Carriers for the Treatment of Leishmaniasis". Journal of Biomedical Nanotechnology 10 12 (2014): 3647-3657. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928499115&partnerID=MN8TOARS.
    10.1166/jbn.2014.1874
  29. Gomes, M.; Gaspar, M.; Carvalheiro, M.; Cruz, M. E. M.; Vale, F. F.. "FUSOGENIC LIPOSOMES AS PROMISING DELIVERY SYSTEMS AGAINST HELICOBACTER PYLORI". Helicobacter 19 (2014): 137-138. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000341623900226&KeyUID=WOS:000341623900226.
  30. Gomes, M.; Lehours, P.; Gaspar, M.; Colla Carvalheiro, M.; Vale, F. F.. "LIPOSOMES AS DRUG DELIVERY SYSTEMS AGAINST HELICOBACTER PYLORI". Helicobacter 18 (2013): 130-130. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000324047300181&KeyUID=WOS:000324047300181.
  31. Lopes, R.M.; Corvo, M.L.; Eleutério, C.V.; Carvalheiro, M.C.; Scoulica, E.; Cruz, M.E.M.. "Formulation of oryzalin (ORZ) liposomes: In vitro studies and in vivo fate". European Journal of Pharmaceutics and Biopharmaceutics 82 2 (2012): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867877363&partnerID=MN8TOARS.
    10.1016/j.ejpb.2012.06.013
  32. Carvalheiro, M.; Jorge, J.; Eleutério, C.; Pinhal, A.F.; Sousa, A.C.; Morais, J.G.; Cruz, M.E.M.. "Trifluralin liposomal formulations active against Leishmania donovani infections". European Journal of Pharmaceutics and Biopharmaceutics 71 2 (2009): 292-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649084848&partnerID=MN8TOARS.
    10.1016/j.ejpb.2008.08.001
  33. Marques, C.; Carvalheiro, M.; Pereira, M.A.; Jorge, J.; Cruz, M.E.M.; Santos-Gomes, G.M.. "Efficacy of the liposome trifluralin in the treatment of experimental canine leishmaniosis". Veterinary Journal 178 1 (2008): 133-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-50449108454&partnerID=MN8TOARS.
    10.1016/j.tvjl.2007.07.016
Capítulo de livro
  1. Faria-Silva, Ana Catarina; Mota, Ana Luísa; Costa, Ana Margarida; Silva, Ana Margarida; Ascenso, Andreia (761B-404D-2C83); Reis, Catarina Pinto; Marto, Joana; et al. "Application of natural raw materials for development of cosmetics through nanotechnology". In Nanotechnology for the Preparation of Cosmetics using Plant-based Extracts, editado por Mohammad Jawaid; Siti Hamidah Mohd Setapar; Akil Ahmad. Elsevier, 2022.
    Aceite para publicação
  2. Simões, S.; Costa, A.; Faria-Silva, A.C.; Ascenso, A.; Marto, J.; Carvalheiro, M.; Gonçalves, L.M.; et al. "Sustainable valorization of food-processing industry by-products: challenges and opportunities to obtain bioactive compounds". In Valorization of Agri-Food Wastes and By-Products, editado por Rajeev Bhat, 619-644. Elsevier, 2021.
    Publicado • 10.1016/b978-0-12-824044-1.00023-4
  3. Faria-Silva, Ana Catarina; Costa, Ana Margarida; Ascenso, Andreia; Ribeiro, Helena Margarida; Marto, Joana; Gonçalves, Lídia Maria; Carvalheiro, Manuela; Simões, Sandra. "Nanoemulsions for cosmetic products". In Nanocosmetics, 59-77. Elsevier, 2020.
    Publicado • 10.1016/b978-0-12-822286-7.00004-8
  4. Carvalheiro, Manuela; Gaspar, Maria Manuela; Simões, Sandra. "Lipid-Based Nanocarriers for the Treatment of Infected Skin Lesions". In Carrier Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorder, editado por Helena M. Ribeiro; Simões, Sandra; Ascenso, Andreia (761B-404D-2C83). Nova Iorque, Estados Unidos: Jenny Stanford Publishing, 2017.
    10.4324/9781315364476-11
Tese / Dissertação
  1. Carvalheiro, Manuela; Carvalheiro, Manuela. "Liposomes as Nanosytems for the Transport and Delivery of Bioactive Agents". Doutoramento, 2011. http://hdl.handle.net/10451/2990.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/07/22 Amphotericin B Deformable Lipid Carriers for Topical Treatment of Cutaneous Leishmaniasis 46th Controlled Release Society (CRS) Annual Meeting and Exposition
Controlled Release Society (Valencia, Espanha)
2017/05/17 Nanoformulations of trifluralin analogues 6th World Congress on Leishmaniasis
Instituto de Salud Carlos III; Drugs for Neglected Diseases initiative (DNDi) (Toledo, Espanha)
2016 Liposomes versus lipid nanoparticles as tools to enhance antileishmanial drugs. Meeting of WG 1 and 4 on: Targeting metabolism and transport in parasites: drugs and delivery systems. Cost Action 1307: Chemotherapy Towards Diseases Caused by Endoparasites.
I3S; ICBAS (Porto, Portugal)
2013/05/16 Hemi-synthetic dinitroanilines in liposomes: combined strategies for improving treatment of Leishmania infantum infection 5th World Congress on Leishmaniasis
Oswaldo Cruz Foundation; Brazilian Society of Tropical Medicine; Brazilian Society of Protozoology; Brazilian Society of Parasitology (Porto de Galinhas, Pernambuco, Brasil)
2011/09/09 Novel drugs and non-conventional formulations as tools for the treatment of Leishmania infections New Indigo Workshop – Antiparasitic and Antitumor Drugs
IBMC (Porto, Portugal)
2009/02/18 Liposomal Trifluralin and Derivatives as Antileishmanial Agents 1st Post-Graduated iMed.UL Students Meeting
Faculdade de Farmácia, Universidade de Lisboa (Lisboa, Portugal)
2006/10/24 Antagonist G targeted stabilized antisense-lipid particles (SALP-G): a novel vector for delivery of antisense oligonucleotides to Small Cell Lung Cancer VII Spanish-Portuguese Conference on Controlled Drug Delivery
Faculty of Pharmacy, University of Navarra (Pamplona, Espanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023 - Atual Biogenic Synthesis of Silver Nanoparticles
Coorientador
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/02 - Atual Inside and Beyond the Colour: unveiling the therapeutic potential of topical glycoalkaloids from green tomatoes
Coorientador
2019/10/01 - Atual The blood brain barrier in brain metastatization of breast cancer: A source of biomarkers, a target for modulation and an obstacle to overcome
Coorientador
 Farmácia Ramo Biologia Molecular (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023 Formulações Lipossomais de Glucocorticóides para o tratamento da Artrite Reumatóide: Preparação, caracterização e avaliação in vitro.
Orientador
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023 Transdermal eyelid delivery for treatment of ophtalmic diseases
Coorientador
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09 - 2021/12 Preserving the blood-brain barrier: a way of preventing breast cancer brain metastases
Coorientador
2019/01/07 - 2019/05/05 Lipid-based nanoformulations of novel seleno-compounds with anti-leishmania activity. Design and development of advanced nanoparticulate drug carrier systems for overcoming biological barriers, particularly for fighting infectious diseases, such as leishmaniasis. Physicochemical, biological (in vitro) and pre-clinical evaluation of advanced drug therapy systems.
Coorientador
 Farmacia + Nutrición Humana y Dietética (Doutoramento)
Universidad de Navarra Facultad de Farmacia y Nutrición, Espanha
2018 - 2018 Lipid-Based Colloidal Systems for Skin Delivery of Anti-Leishmanial Drugs
Orientador
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/02/12 - 2017/08/05 Advanced Lipid Carriers for Topical Treatment of Cutaneous Leishmaniasis. To develop and evaluate lipid nanocarriers as systems for topical administration of drugs: - Preparation and physico-chemical characterization of nanocarriers containing antileishmanial agents - In vitro evaluation of permeation and skin retention - In vitro evaluation of biological activity ERASMUS Programm
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2017 Formulations of Ethosomes with Amphotericin B (AmB) as an alternative for Cutaneous Leishmaniasis (CL) Treatment
Orientador
 Mestrado Integrado em Ciências Farmacêuticas (Outra)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Lipid-Based Vesicles for Oryzalin Incorporation. Preparation, Characterisation and in vitro Studies
Orientador
 Mestrado Integrado em Ciências Farmacêuticas (Outra)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Development and Characterisation of Lipid-Based Systems for a Bioactive Agent
Orientador
 Mestrado Integrado em Ciências Farmacêuticas (Outra)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/09 - 2014/02 Pesquisa de proteínas líticas fágicas e formulações lipossomais para a sua entrega a Helicobacter pylori
Coorientador
 Engenharia Biomédica (Mestrado)
Universidade Católica Portuguesa, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2007/06/10 - 2007/06/15 The ESF Summer School has been designed to provide an intensive state-of the- art training across all of the sub-disciplines of Nanomedicine, and to foster discussion and exchange of ideas. The lectures, tutorials and interactive workshops will particularly cover all aspects that are needed to transfer new nanotechnologies from bench to bedside – from materials science and engineering to clinical need, from rational design of nanopharmaceuticals, imaging agents and constructs for tissue engineering to safe and practical development.
Outro
 1st European Science Foundation Summer School in Nanomedicine
European Science Foundation, França
2004/08/30 - 2004/09/10 Post-graduate Course - The course aims to prepare researchers for the appropriate use of animals in scientific experiments. This theoretical and practical course will cover the biology and husbandry of laboratory animals, aspects of microbiology and disease, health hazards and safe practices in the animal house, the design and conduct of animal experiments, anaesthesia, analgesia and experimental procedures, as well as the ethical and legal aspects of animal experimentation and alternatives to animal use.
Outro
 Course on Laboratory Animal Science (FELASA – LEVEL C)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003/06/25 - 2003/06/27 Short Course on Cell and Tissue Culture - The purpose of this short course is to improve the participants' knowledge of theoretical / practical aspects related to cell and tissue culture.
Outro
 Cell and Tissue Culture
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2000/07/27 - 2000/08/01 Radiation Safety Course - In order to work with nuclear substances, individuals must have completed the Radiation Safety Course offered by EHS. EHS trains users and issues Radionuclide Permits under the Canadian Nuclear Safety Commission (CNSC) Licence issued to the University of Alberta.
Outro
 Radiation Safety Course.
University of Alberta, Canadá
2000/07/13 - 2000/07/14 The Care and Use of the Laboratory Mouse. Mandatory training course for animal users at the University of Alberta, Edmonton, Canada.
Outro
 The Care and Use of the Laboratory Mouse
University of Alberta Health Sciences Laboratory Animal Services, Canadá
1999/07/05 - 1999/07/09 Cytokines
Oficina (workshop)
 Cytokines
Instituto Gulbenkian de Ciência, Portugal
1999/06/24 - 1999/07/05 Targeting of Drugs: Strategies for Gene Constructs and Deliver - This workshop deals with developments in circumventing the problems of direct DNA administration by the use of viral or non-viral vectors. Representatives from both camps of therapy discuss the challenges and opportunities of the two approaches and present the latest progress with a variety of constructs (viral and non-viral).
Oficina (workshop)
 Targeting of Drugs: Strategies for Gene Constructs and Delivery
NATO, Bélgica
1997/06/24 - 1997/07/05 Targeting of Drugs: Strategies for Stealth Therapeutic Systems - This workshop discusses in great depth the present and the future of the very importante research field of drug delivery. In particular, deals with a variety of approaches to evade the reticuloendothelial system and thus extend the circulation time of a variety of delivery systems including polymers, biopolymers, liposomes, and other nanoparticles or microparticles.
Oficina (workshop)
 Targeting of Drugs: Strategies for Stealth Therapeutic Systems
NATO, Bélgica
1995/09/14 - 1995/09/19 Short Course on: Liposome Technology - Clinical and Industrial Applications.
Oficina (workshop)
 Liposome Technology - Clinical and Industrial Applications
Instituto Nacional de Engenharia e Tecnologia Industrial, Portugal
1993/10/11 - 1993/10/13 Yeast in Foods, Beverages & other products - A specialist course aimed at problem solving.
Oficina (workshop)
 Yeast in Foods, Beverages & other products - A specialist course aimed at problem solving.
CABI, Reino Unido

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/11/22 Evaluation of Microneedle Arrays as potential delivery systems for bacterial extracellular vesicles
Arguente
 Miriam Domingos de Sousa (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/24 Innovative sporopollenin microgranules delivery system with photoprotective activity
Arguente
 Isabel Tomás Roça (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/22 New Insights in Permeability Studies: Bioprinted 3D Skin Models vs Biological Skin
Arguente
 Ana Filipa Vinhas Agostinho Matos (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/09/29 Nanoencapsulation of New Compounds with Potential Antileishmanial Activity
Arguente
 Jõao Pedro Vitorino Quintas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Estudo do direcionamento ativo de nanossistemas lipídicos com antagonista G para células de cancro de pulmão
Arguente principal
 Ana Margarida Ferreira da Silva (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 Management of Skin Cancer by Agonist of 5-HTI A and Antagonist of 5-HT2A receptors
Arguente
 Ana Catarina da Silva Fernandes Saraiva de Menezes (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018 - Atual Curso Pós-Graduado de Atualização de Ciências em Animais de Laboratório – Categoria B (Pós-Graduação) Universidade de Lisboa Faculdade de Farmácia, Portugal

Membro de associação

Nome da associação Tipo de participação
2019 - Atual Spanish Portuguese Local Chapter, controlled Release Society

Tutoria

Tópico Nome do aluno
2021/09/01 - 2023/03 Development and characterization of an innovative drug delivery platform targeting breast cancer brain metastases Joana Raquel Aniceto Romão
Distinções

Prémio

2019 Prêmio Octavio Frias de Oliveira 2019 na categoria Inovação Tecnológica em Oncologia
Universidade de São Paulo Instituto do Câncer do Estado de São Paulo, Brasil