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Nuno C. Santos was born in Lisbon, Portugal, in 1972. He graduated in Biochemistry from the Faculty of Science, University of Lisbon, in 1995, and received his PhD in Theoretical and Experimental Biochemistry in 1999 from the same University, although all the experimental work was conducted at Instituto Superior Técnico (Technical University of Lisbon) and University of California (Santa Barbara). Currently, he is Associate Professor with Habilitation of the Faculty of Medicine, University of Lisbon, and Head of the Biomembranes & Nanomedicine Unit at the Gulbenkian Institute for Molecular Medicine (GIMM), which was created in 2024 upon the merging between Instituto de Medicina Molecular (iMM), where he was previously Group Leader, and Instituto Gulbenkian de Ciência (IGC). Among other distinctions, his research work was awarded with the Gulbenkian Prize for young researchers (2001), Dr. José Luis Champalimaud Prize – Basic Research (2004), Dr. José Luis Champalimaud Prize – Applied Research and Technology (2005) and the ULisboa – Caixa Geral de Depósitos Prize (2017 and 2023). He is (co)author of 194 articles in per-reviewed international journals, which received more than 11 300 citations (h index 57 and i10-index 151, publishing since 1996), presenting a Journal Citation Reports impact factor sum of 1069.0 (average 5.6 per article). In addition to these publications, he (co)authored 10 articles in Portuguese scientific journals, 15 book chapters (mostly published outside Portugal, in English), 3 books (editor, published by Wiley, Springer and MDPI) and 2 international patents. Among different National and International research projects, he was the coordinator of a European Union-funded consortium including 10 different research groups from Europe and Brazil. His Lab is currently involved in 9 funded research projects (European Commission, la Caixa Foundation, FCT, Portugal 2030) He is member of the Executive Committee of the European Biophysical Societies’ Association (EBSA) since 2019, and the Director of the M2B-PhD Doctoral Program in Medical Biochemistry and Biophysics (involving 5 different institutions) since 2016. He was President of the Portuguese Biophysical Society from 2015 to 2021. He has supervised 17 completed PhDs, 10 as main supervisor and 7 as co-supervisor. (April 2025)
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Identificação

Identificação pessoal

Nome completo
Nuno Fernando Duarte Cordeiro Correia dos Santos

Nomes de citação

  • Santos, Nuno C.
  • Santos, N.C.

Identificadores de autor

Ciência ID
CD13-5E3A-A3C5
ORCID iD
0000-0002-0580-0475
Google Scholar ID
hmISCFoAAAAJ&hl

Endereços de correio eletrónico

  • nsantos@medicina.ulisboa.pt (Profissional)
  • nsantos@fm.ul.pt (Profissional)
  • nuno.santos@gimm.pt (Profissional)

Moradas

  • Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biofísica
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Métodos de Investigação Bioquímica
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências Naturais - Ciências Biológicas - Virologia
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências da Engenharia e Tecnologias - Engenharia Médica - Engenharia Médica
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Medicina Clínica - Sistemas Cardíacos e Cardiovasculares
  • Ciências Médicas e da Saúde - Medicina Clínica - Endocrinologia e Metabolismo
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2010/06/15
Concluído
 Ciências Biomédicas (Título de Agregado)
Universidade de Lisboa Faculdade de Medicina, Portugal
1999/11/16
Concluído
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

University of California Santa Barbara Department of Chemical Engineering, Estados Unidos
1995/07/20
Concluído
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 16.5
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/10/01 - Atual Investigador principal (carreira) (Investigação) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2008/01/01 - 2024/09/30 Investigador principal (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal
1994/09/01 - 1999/02/28 Investigador (Investigação) Universidade de Lisboa Centro de Química-Física Molecular, Portugal
1997/02/01 - 1997/05/31 Investigador visitante (Investigação) University of California at Santa Barbara, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2013 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
2000/03/01 - 2010/06/15 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
1999/03/01 - 2000/02/29 Assistente Estagiário (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2023/10 - 2025/10 COLOR2COAT: Nano-coatings for prosthetics based on microbial phenazines conjugated with silver nanostars (CI23-10134)
CI23-10134
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Em curso
2021/03/29 - 2024/03/28 Fibrinogen-erythrocyte interaction as a new approach on the early detection of thrombotic events in vascular diseases
PTDC/EMD-TLM/7289/2020
Investigador responsável
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/04/01 - 2023/03/31 SAFETY TESTING IN THE LIFE CYCLE OF NANOTECHNOLOGY-ENABLED MEDICAL TECHNOLOGIES FOR HEALTH.
info:eu-repo/grantAgreement/EC/H2020/814607/EU
Investigador
European Commission
Em curso
2018/10/01 - 2021/09/30 iDNArT - Intelligent DNA nanostructures aimed at brain therapeutics
PTDC/NAN-MAT/30898/2017
Investigador
Em curso
2018/10/01 - 2021/09/30 When the host cell is not so cosy anymore? A drop off in energy or an increase in toxicity?
PTDC/BIA-CEL/28456/2017
Investigador
Em curso
2016/05/01 - 2019/10/31 Broad-spectrum antiviral peptides against respiratory viruses
PTDC/BBB-BQB/3494/2014
Investigador responsável
Concluído
2016/05/01 - 2019/10/31 Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies
PTDC/BBB-BMD/6307/2014
Investigador
Concluído
2015/02/01 - 2019/01/31 Engineering protease-resistant alpha-beta peptides for broad-spectrum antivirals
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES/5R01AI114736-04/US
Investigador
2015/02/01 - 2019/01/31 Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.
info:eu-repo/grantAgreement/EC/H2020/644167/EU
Investigador
Concluído
2012/03/01 - 2015/08/31 AMYLOIDETECTORS: Employing amyloid fibrils as biosensors of the interaction of peptides with phospholipids and/or protein domains.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/117013/PT
Investigador
Concluído
2012/03/01 - 2015/08/31 Molecular characterization of the fibrinogen-eryhthrocyte interaction and its influence on Cardivascular pathologies
info:eu-repo/grantAgreement/FCT/3599-PPCDT/119509/PT
Investigador responsável
Concluído
2012/02/01 - 2015/01/31 ADHESION, DIFFERENTIATION AND INVASION: DIFFERENT PROCESSES, COMMON CADHERIN PLAYERS
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F757052%F2011/PT
Investigador
Concluído
2011/03/01 - 2014/08/31 Membrane fusion mechanism of Influenza Hemagglutinin: a simulation and biophysical approach.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/114774/PT
Investigador
Concluído
2011/03/01 - 2014/08/31 LIPIDENGUE: The role of hepatic lipid membranes and lipid droplets in Dengue virus encapsidation. A gateway to new therapies.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/112929/PT
Investigador
Concluído
2010/01/31 - 2014 Membrane-active peptides across disciplines and continents: An integrated approach to find new strategies to fight bacteria, dengue virus and neurodegeneration.
info:eu-repo/grantAgreement/EC/FP7/247513/EU
Investigador responsável
Concluído
2011/07/15 - 2013/03/31 Cell membrane features in HIV entry and its inhibition
info:eu-repo/grantAgreement/FCT/3599-PPCDT/104787/PT
Investigador responsável
Concluído
2009/03/01 - 2013/02/28 Selected peptides as drug candidates directed to pain and neurodegeneration
info:eu-repo/grantAgreement/EC/FP7/230654/EU
Investigador
Concluído
2010/02/01 - 2013/01/31 Inherent antibacterial activity in peptide-based hydrogels for tissue regeneration
info:eu-repo/grantAgreement/FCT/3599-PPCDT/99142/PT
Investigador
2010/01/01 - 2012/12/31 MULTI-TARGET HIV ENTRY INHIBITORS DELIVERY BY CATIONIC LIPOSOMES
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F655312%F2009/PT
Investigador
Concluído
2008/02/11 - 2011/06/09 Metal- and magnetic nanoparticles functionalized with biological molecules: towards bio-nanoprobes
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/64484/PT
Investigador
Concluído
2009/06/05 - 2011/06/04 The role of lipid membranes in dengue virus assembly
info:eu-repo/grantAgreement/EC/FP7/237373/EU
Orientador
2007/12/01 - 2011/05/30 The role of lipid membranes in Dengue virus cell infection
info:eu-repo/grantAgreement/FCT/3599-PPCDT/69937/PT
Investigador
Concluído
2007/01/01 - 2010/03/31 Fibrinogen and signal transduction on Microcirculation – Implications in inflammation and cardiovascular diseases
PTDC/SAU-OSM/73449/2006
Investigador
Concluído
2000/11/01 - 2002/10/31 The interaction of HIV-1 membrane protein gp41 fusion peptide with biomembranes and its inhibition
info:eu-repo/grantAgreement/FCT/POCI/12049/PT
Investigador
Concluído

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Institute of Molecular Medicine João Lobo Antunes
LA/P/0082/2020
10.54499/LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2025/06/30 COoperative Mechanical couPling of adherens junctions and focaL adhesIons supporting breast CancEr progression
PTDC/BIA-BFS/0812/2021
10.54499/PTDC/BIA-BFS/0812/2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2023/02/01 - 2025/01/31 Biophysical studies of flavivirus capsid protein interactions with key biological targets to achieve its future inhibition
2022.02763.PTDC
10.54499/2022.02763.PTDC
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2023/03/10 - 2024/12/09 AMP-AgNP conjugates: the mutual reinforcement of antibacterial activity
2022.01991.PTDC
10.54499/2022.01991.PTDC
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2021/03/29 - 2024/09/28 Fibrinogen-erythrocyte interaction as a new approach on the early detection of thrombotic events in vascular diseases
PTDC/EMD-TLM/7289/2020
10.54499/PTDC/EMD-TLM/7289/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2022/04/01 - 2023/09/30 Unveiling pericyte dynamics during vascular development
EXPL/MED-ANM/1616/2021
10.54499/EXPL/MED-ANM/1616/2021
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2019/10/31 Broad-spectrum antiviral peptides against respiratory viruses
PTDC/BBB-BQB/3494/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/05/01 - 2019/10/31 Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies
PTDC/BBB-BMD/6307/2014
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/05/01 - 2016/10/31 Multi-target HIV entry inhibitors delivery by cationic liposomes
VIH/SAU/0047/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2014/03/01 - 2016/08/31 An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes
HIVERA/0003/2013
Universitat Autònoma de Barcelona, Espanha

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centre National de la Recherche Scientifique, França
Fundação para a Ciência e a Tecnologia
Concluído
2014/03/01 - 2016/08/31 An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes
HIVERA/0002/2013
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centre National de la Recherche Scientifique, França

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/03/01 - 2015/10/31 Adhesion, Differentiation and Invasion: different processes, common cadherin players
PTDC/SAU-GMG/120049/2010
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/03/01 - 2015/08/31 Molecular characterization of the fibrinogen-eryhthrocyte interaction and its influence on Cardivascular pathologies
PTDC/QUI-BIQ/119509/2010
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2014/08/31 LIPIDENGUE: The role of hepatic lipid membranes and lipid droplets in Dengue virus encapsidation. A gateway to new therapies.
PTDC/QUI-BIQ/112929/2009
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Amyloidogenic proteins: role of lipid-protein interaction in amyloid-like fibril formation
PTDC/QUI-BIQ/099947/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química-Física Molecular, Portugal

Universidade de Évora, Portugal

Universidade de Évora Centro de Química de Évora, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/03/31 Cell membrane features in HIV entry and its inhibition
PTDC/QUI-BIQ/104787/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2013/02/17 Strategic Project - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/01/31 Inherent antibacterial activity in peptide-based hydrogels for tissue regeneration
PTDC/SAU-BEB/099142/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

University of Delaware Department of Chemistry & Biochemistry, Estados Unidos
Fundação para a Ciência e a Tecnologia
Concluído
2008/02/11 - 2011/06/09 Metal- and magnetic nanoparticles functionalized with biological molecules: towards bio-nanoprobes
PTDC/QUI/64484/2006
Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2024/01 - 2025/01 IMPLAT: A single-cell platform to validate material scaffolds and drugs for the enhanced osteointegration of biomedical implants
Project#11 IMPLAT
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Em curso
Produções

Publicações

Artigo em conferência
  1. Villarroel-Ortega, Jorge; Santos, N.C.; Correia, A.A.S.; Lemos, Luís; Venda Oliveira, P.J.. Autor correspondente: Villarroel-Ortega, Jorge. "Efeito do teor da água, quantidade de ligantes e tempo de cura no comportamento mecânico de um solo mole estabilizado quimicamente". Trabalho apresentado em 17º Congresso Nacional de Geotecnia, Lisboa, 2021.
    Publicado
Artigo em revista
  1. Marlon H. Cardoso; Cesar de la Fuente-Nunez; Nuno C. Santos; Michael A. Zasloff; Octávio L. Franco. "Influence of antimicrobial peptides on the bacterial membrane curvature and vice versa". Trends in Microbiology (2024): https://doi.org/10.1016/j.tim.2024.04.012.
    10.1016/j.tim.2024.04.012
  2. Liana Costa Pereira Vilas Boas; Danieli Fernanda Buccini; Rhayfa Lorrayne Araújo Berlanda; Bruno de Paula Oliveira Santos; Mariana Rocha Maximiano; Luciano Morais Lião; Sónia Gonçalves; Nuno C. Santos; Octávio Luiz Franco. "Antiviral Activities of Mastoparan-L-Derived Peptides against Human Alphaherpesvirus 1". Viruses (2024): https://doi.org/10.3390/v16060948.
    10.3390/v16060948
  3. Martins, Ana S. G.; Reis, Sara D.; Benson, Erik; Domingues, Marco M.; Cortinhas, João; Vidal Silva, Joana A.; Santos, Sofia D.; et al. "Enhancing Neuronal Cell Uptake of Therapeutic Nucleic Acids with Tetrahedral DNA Nanostructures". Small (2024): http://dx.doi.org/10.1002/smll.202309140.
    10.1002/smll.202309140
  4. Artur J. M. Valente; Nuno C. Santos; Maria João Moreno. "State-of-the-Art Macromolecules in Portugal". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25010620.
    10.3390/ijms25010620
  5. Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, Nuno; Atalaia-Barbacena, Henrique; et al. "A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease". (2024): http://hdl.handle.net/10362/173840.
    https://doi.org/10.1016/j.ymthe.2024.08.022
  6. Catarina S. Lopes; Ana Catarina Pronto-Laborinho; Vasco A. Conceição; Teresa Freitas; Gonçalo L. Matias; Marta Gromicho; Nuno C. Santos; Mamede de Carvalho; Filomena A. Carvalho. "Erythrocytes' surface properties and stiffness predict survival and functional decline in ALS patients". BioFactors (2023): https://doi.org/10.1002/biof.2030.
    10.1002/biof.2030
  7. Costa, Igor S. D.; Junot, Tiago; Silva, Fernanda L.; Felix, Wanessa; Cardozo Fh, José L.; Pereira de Araujo, Antonio F.; Pais do Amaral, Constança; et al. "Occurrence and evolutionary conservation analysis of a-helical cationic amphiphilic segments in the human proteome". The FEBS Journal (2023): http://dx.doi.org/10.1111/febs.16997.
    Publicado • 10.1111/febs.16997
  8. Sónia Gonçalves; Nuno C. Santos. "Membrane–Peptide Interactions: From Basics to Current Applications 2.0". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24087202.
    10.3390/ijms24087202
  9. Lopes, Catarina S.; Curty, Juliana; Carvalho, Filomena Almeida; Hernández-Machado, A.; Kinoshita, Koji; Santos, Nuno C.; Travasso, Rui D. M.; et al. "A mathematical model of fibrinogen-mediated erythrocyte–erythrocyte adhesion". Communications Biology (2023): http://hdl.handle.net/10451/56478.
    10.1038/s42003-023-04560-4
  10. Cerqueira, Miguel A.; Leite, Ana C. C. O.; Tomás, Ana L.; Reichel, Anna; Silva, Patrícia M.; Santos, Nuno C.; Michelin, Michele; et al. "Edible alginate-based films with anti-SARS-CoV-2 activity". (2023): https://hdl.handle.net/1822/83398.
    10.1016/j.fm.2023.104251
  11. Makowski, Marcin; Almendro-Vedia, Víctor G.; Domingues, Marco; Franco, Octavio L.; López-Montero, Iván; Melo, Manuel N.; Santos, Nuno C.. "Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering". (2023): http://hdl.handle.net/10451/58716.
    10.1016/j.isci.2023.107004
  12. Carvalho, Maria; Medeiros, Márcia M.; Morais, Inês; Lopes, Catarina S.; Balau, Ana; Santos, Nuno C.; Carvalho, Filomena A.; et al. "2,3-Diphosphoglycerate and the Protective Effect of Pyruvate Kinase Deficiency against Malaria Infection—Exploring the Role of the Red Blood Cell Membrane". International Journal of Molecular Sciences (2023): http://hdl.handle.net/10362/149210.
    https://doi.org/10.3390/ijms24021336
  13. Boon, Priscilla L. S.; Silva Martins, Ana; Lim, Xin Ni; Enguita, Francisco J.; Santos, Nuno C.; Bond, Peter J.; Wan, Yue; et al. "Dengue virus capsid protein facilitates genome compaction and packaging". International Journal of Molecular Sciences (2023): http://hdl.handle.net/10451/57722.
    10.3390/ijms24098158
  14. Fonseca Gomes, J; Rodrigues, Tiago M; Vaz, Sandra H; Ramalho, R M; Vicente Miranda, Hugo; Tanqueiro, S; Miranda-Lourenço, C; et al. "A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer's Disease (Submitted)". (2023):
    Submetido
  15. Ivo C. Martins; Rafaela C. Ricardo; Nuno C. Santos. "Dengue, West Nile, and Zika Viruses: Potential Novel Antiviral Biologics Drugs Currently at Discovery and Preclinical Development Stages". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14112535.
    10.3390/pharmaceutics14112535
  16. Sónia Gonçalves; Ivo C. Martins; Nuno C. Santos. "Nanoparticle-peptide conjugates for bacterial detection and neutralization: Potential applications in diagnostics and therapy". WIREs Nanomedicine and Nanobiotechnology (2022): https://doi.org/10.1002/wnan.1819.
    10.1002/wnan.1819
  17. Maïssa Dardouri; Ana Bettencourt; Victor Martin; Filomena A. Carvalho; Bruno Colaço; Adelina Gama; Madeleine Ramstedt; et al. "Assuring the Biofunctionalization of Silicone Covalently Bonded to Rhamnolipids: Antibiofilm Activity and Biocompatibility". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091836.
    10.3390/pharmaceutics14091836
  18. Patrícia M. Silva; Inês Vieira da Silva; Maria J. Sarmento; Silva, Í. C.; Filomena A. Carvalho; Graça Soveral; Nuno C. Santos. "Aquaporin-3 and Aquaporin-5 Facilitate Migration and Cell–Cell Adhesion in Pancreatic Cancer by Modulating Cell Biomechanical Properties". Cells (2022): https://www.mdpi.com/2073-4409/11/8/1308.
    10.3390/cells11081308
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  26. Tânia B. Cruz; Filomena A. Carvalho; Paulo N. Matafome; Raquel A. Soares; Nuno C. Santos; Rui D. Travasso; Maria J. Oliveira. "Mice with Type 2 Diabetes Present Significant Alterations in Their Tissue Biomechanical Properties and Histological Features". Biomedicines (2021): https://doi.org/10.3390/biomedicines10010057.
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  27. Borges-Araújo, Luís; Domingues, Marco M.; Fedorov, Alexander; Santos, Nuno C.; Melo, Manuel N.; Fernandes, Fábio. "Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains". Communications Chemistry 4 1 (2021): http://dx.doi.org/10.1038/s42004-021-00603-1.
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  32. Marco M. Domingues; Bárbara Gomes; Axel Hollmann; Nuno C. Santos; Domingues, Marco; Gomes, Bárbara; Hollmann, Axel; Santos, Nuno C.. "25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties". International Journal of Molecular Sciences 22 5 (2021): 2574-2574. https://doi.org/10.3390/ijms22052574.
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  136. Carvalho, F.A.; de Oliveira, S.; Freitas, T.; Gonçalves, S.; Santos, N.C.. "Variations on fibrinogen-erythrocyte interactions during cell aging". PLoS ONE 6 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953147017&partnerID=MN8TOARS.
    10.1371/journal.pone.0018167
  137. Franquelim, H.G.; Chiantia, S.; Veiga, A.S.; Santos, N.C.; Schwille, P.; Castanho, M.A.R.B.. "Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes". AIDS 25 4 (2011): 419-428. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951514918&partnerID=MN8TOARS.
    10.1097/QAD.0b013e328342ff11
  138. Castanho, M.; Santos, N.C.; Santos, Nuno C.. "Peptide Drug Discovery and Development: Translational Research in Academia and Industry". Peptide Drug Discovery and Development: Translational Research in Academia and Industry (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84869033333&partnerID=MN8TOARS.
    10.1002/9783527636730
  139. Martins, A.P.; Lopes, P.A.; Costa, A.S.H.; Martins, S.V.; Santos, N.C.; Prates, J.A.M.; Moura, T.F.; Soveral, G.. "Differential mesenteric fat deposition in bovines fed on silage or concentrate is independent of glycerol membrane permeability". Animal 5 12 (2011): 1949-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955160624&partnerID=MN8TOARS.
    10.1017/S1751731111001091
  140. Rodrigues, M.; De La Torre, B.G.; Rádis-Baptista, G.; Santos, N.C.; Andreu, D.. "Efficient cellular delivery of ß-galactosidase mediated by NrTPs, a new family of cell-penetrating peptides". Bioconjugate Chemistry 22 11 (2011): 2339-2344. http://www.scopus.com/inward/record.url?eid=2-s2.0-81255189096&partnerID=MN8TOARS.
    10.1021/bc200421z
  141. Franquelim, H.G.; De-Sousa, F.F.; Veiga, A.S.; Santos, N.C.; Castanho, M.A.R.B.. "Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide". Soft Matter 7 23 (2011): 11089-11092. http://www.scopus.com/inward/record.url?eid=2-s2.0-81355123272&partnerID=MN8TOARS.
    10.1039/c1sm06553j
  142. Franquelim, H.G.; Veiga, A.S.; Weissmüller, G.; Santos, N.C.; Castanho, M.A.R.B.. "Unravelling the molecular basis of the selectivity of the HIV-1 fusion inhibitor sifuvirtide towards phosphatidylcholine-rich rigid membranes". Biochimica et Biophysica Acta - Biomembranes 1798 6 (2010): 1234-1243. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952551415&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.02.010
  143. Santos, N.C.. "In and out - Biochemical and biophysical mechanisms of viral fusion and assembly". TheScientificWorldJournal 10 (2010): 419-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951761669&partnerID=MN8TOARS.
    10.1100/tsw.2010.53
  144. Santos, N.C.; Martins E Silva, J.; Freitas, T.; Doroana, M.; Duarte, N.; Tavares, L.; Antunes, F.; Saldanha, C.. "Blood cell membrane fluidity and intracellular Ca2+changes in antiretroviral-naïve and -treated HIV-1-infected patients". TheScientificWorldJournal 10 (2010): 350-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749327970&partnerID=MN8TOARS.
    10.1100/tsw.2010.34
  145. Alves, C.S.; Melo, M.N.; Franquelim, H.G.; Ferre, R.; Planas, M.; Feliu, L.; Bardají, E.; et al. "Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR". Journal of Biological Chemistry 285 36 (2010): 27536-27544. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956238793&partnerID=MN8TOARS.
    10.1074/jbc.M110.130955
  146. Matos, P.M.; Castanho, M.A.R.B.; Santos, N.C.. "HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes". PLoS ONE 5 3 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956502249&partnerID=MN8TOARS.
    10.1371/journal.pone.0009830
  147. Matos, P.M.; Franquelim, H.G.; Castanho, M.A.R.B.; Santos, N.C.. "Quantitative assessment of peptide-lipid interactions. Ubiquitous fluorescence methodologies". Biochimica et Biophysica Acta - Biomembranes 1798 11 (2010): 1999-2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953139417&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.07.012
  148. Santiago, P.S.; Carvalho, J.W.P.; Domingues, M.M.; Santos, N.C.; Tabak, M.. "Thermal stability of extracellular hemoglobin of Glossoscolex paulistus: Determination of activation parameters by optical spectroscopic and differential scanning calorimetric studies". Biophysical Chemistry 152 1-3 (2010): 128-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149282480&partnerID=MN8TOARS.
    10.1016/j.bpc.2010.08.010
  149. Ribeiro, M.M.B.; Melo, M.N.; Serrano, I.D.; Santos, N.C.; Castanho, M.A.R.B.. "Drug-lipid interaction evaluation: Why a 19th century solution?". Trends in Pharmacological Sciences 31 10 (2010): 449-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956909526&partnerID=MN8TOARS.
    10.1016/j.tips.2010.06.007
  150. Matos, P.M.; Freitas, T.; Castanho, M.A.R.B.; Santos, N.C.. "The role of blood cell membrane lipids on the mode of action of HIV-1 fusion inhibitor sifuvirtide". Biochemical and Biophysical Research Communications 403 3-4 (2010): 270-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650172669&partnerID=MN8TOARS.
    10.1016/j.bbrc.2010.11.013
  151. Carvalho, F.A.; Connell, S.; Miltenberger-Miltenyi, G.; Pereira, S.V.; Tavares, A.; Ariëns, R.A.S.; Santos, N.C.. "Atomic force microscopy-based molecular recognition of a fibrinogen receptor on human erythrocytes". ACS Nano 4 8 (2010): 4609-4620. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650138418&partnerID=MN8TOARS.
    10.1021/nn1009648
  152. Martins, A.P.; Lopes, P.A.; Martins, S.V.; Madeira, A.; Santos, N.C.; Prates, J.A.M.; Moura, T.F.; Soveral, G.. "Conjugated linoleic acid reduces permeability and fluidity of adipose plasma membranes from obese Zucker rats". Biochemical and Biophysical Research Communications 398 2 (2010): 199-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955057876&partnerID=MN8TOARS.
    10.1016/j.bbrc.2010.06.059
  153. Santiago, P.S.; Carvalho, F.A.O.; Domingues, M.M.; Carvalho, J.W.P.; Santos, N.C.; Tabak, M.. "Isoelectric point determination for Glossoscolex paulistus extracellular hemoglobin: Oligomeric stability in acidic pH and relevance to protein-surfactant interactions". Langmuir 26 12 (2010): 9794-9801. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956081477&partnerID=MN8TOARS.
    10.1021/la100060p
  154. Domingues, M.M.; Lopes, S.C.D.N.; Santos, N.C.; Quintas, A.; Castanho, M.A.R.B.. "Fold-Unfold transitions in the selectivity and mechanism of action of the N-Terminal fragment of the bactericidal/permeability-increasing protein (rBPI21)". Biophysical Journal 96 3 (2009): 987-996. http://www.scopus.com/inward/record.url?eid=2-s2.0-61549096250&partnerID=MN8TOARS.
    10.1016/j.bpj.2008.10.044
  155. Domingues, M.M.; Castanho, M.A.R.B.; Santos, N.C.; Domingues, Marco; Castanho, Miguel A. R. B.; Santos, Nuno C.. "rBPI21 promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes". PLoS ONE 4 12 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-77949517357&partnerID=MN8TOARS.
    10.1371/journal.pone.0008385
  156. Vieira, C.R.; Castanho, M.; Saldanha, C.; Santos, N.C.. "Enfuvirtide effects on human erythrocytes and lymphocytes functional properties". Journal of Peptide Science 14 4 (2008): 448-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149163387&partnerID=MN8TOARS.
    10.1002/psc.1006
  157. Matos, P.M.; Gonçalves, S.; Santos, N.C.. "Interaction of peptides with biomembranes assessed by potential-sensitive fluorescent probes". Journal of Peptide Science 14 4 (2008): 407-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149117742&partnerID=MN8TOARS.
    10.1002/psc.1005
  158. Domingues, M.M.; Santiago, P.S.; Castanho, M.A.R.B.; Santos, N.C.. "What can light scattering spectroscopy do for membrane-active peptide studies?". Journal of Peptide Science 14 4 (2008): 394-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149116252&partnerID=MN8TOARS.
    10.1002/psc.1007
  159. Santiago, P.S.; Moura, F.; Moreira, L.M.; Domingues, M.M.; Santos, N.C.; Tabak, M.. "Dynamic light scattering and optical absorption spectroscopy study of pH and temperature stabilities of the extracellular hemoglobin of glossoscolex paulistus". Biophysical Journal 94 6 (2008): 2228-2240. http://www.scopus.com/inward/record.url?eid=2-s2.0-44049099950&partnerID=MN8TOARS.
    10.1529/biophysj.107.116780
  160. Gomes, I.; Santos, N.C.; Oliveira, L.M.-A.; Quintas, A.; Eaton, P.; Pereira, E.; Franco, R.. "Probing surface properties of cytochrome c at Au bionanoconjugates". Journal of Physical Chemistry C 112 42 (2008): 16340-16347. http://www.scopus.com/inward/record.url?eid=2-s2.0-55649094472&partnerID=MN8TOARS.
    10.1021/jp804766v
  161. Franquelim, H.G.; Loura, L.M.S.; Santos, N.C.; Castanho, M.A.R.B.. "Sifuvirtide screens rigid membrane surfaces. Establishment of a correlation between efficacy and membrane domain selectivity among HIV fusion inhibitor peptides". Journal of the American Chemical Society 130 19 (2008): 6215-6223. http://www.scopus.com/inward/record.url?eid=2-s2.0-43249117737&partnerID=MN8TOARS.
    10.1021/ja711247n
  162. Gonçalves, S.; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Fluorescence spectroscopy evaluation of fibrinogen-ß-estradiol binding". Journal of Photochemistry and Photobiology B: Biology 86 2 (2007): 170-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845567319&partnerID=MN8TOARS.
    10.1016/j.jphotobiol.2006.09.001
  163. Veiga, S.; Yuan, Y.; Li, X.; Santos, N.C.; Liu, G.; Castanho, M.A.R.B.. "Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions". Biochimica et Biophysica Acta - General Subjects 1760 1 (2006): 55-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-29044440663&partnerID=MN8TOARS.
    10.1016/j.bbagen.2005.10.001
  164. Martins-Silva, J.; Santos, N.C.; Doroana, M.; Duarte, N.; Tavares, L.; Antunes, F.; Saldanha, C.. "Changes in blood cell membrane properties in HIV type-1-infected patients". AIDS Research and Human Retroviruses 22 9 (2006): 849-853. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751026185&partnerID=MN8TOARS.
    10.1089/aid.2006.22.849
  165. Gonçalves, S.; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Fibrinogen-ß-estradiol binding studied by fluorescence spectroscopy: Denaturation and pH effects". Journal of Fluorescence 16 2 (2006): 207-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646711479&partnerID=MN8TOARS.
    10.1007/s10895-005-0051-y
  166. Veiga, A.S.; Santos, N.C.; Castanho, M.A.. "An insight on the leading HIV entry inhibitors.". Recent patents on anti-infective drug discovery 1 1 (2006): 67-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-39049093808&partnerID=MN8TOARS.
    10.2174/157489106775244046
  167. Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Gramicidin D and dithiothreitol effects on erythrocyte exovesiculation". Cell Biochemistry and Biophysics 43 3 (2005): 419-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144489727&partnerID=MN8TOARS.
    10.1385/CBB:43:3:419
  168. Santos, Nuno C.; Martins e Silva, João; Saldanha, Carlota; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "PTEN “meets” DMSO". Leukemia Research 29 4 (2005): 361-362. http://hdl.handle.net/10451/44650.
    10.1016/j.leukres.2004.09.009
  169. Saldanha, C.; Santos, N.C.; Martins-Silva, J.; Saldanha, Carlota; Santos, Nuno C.; Martins e Silva, João. "A colorimetric process to visualize erythrocyte exovesicles aggregates". Biochemistry and Molecular Biology Education 32 4 (2004): 250-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242803480&partnerID=MN8TOARS.
    10.1002/bmb.2004.494032040374
  170. Santos, N.C.; Castanho, M.A.R.B.. "An overview of the biophysical applications of atomic force microscopy". Biophysical Chemistry 107 2 (2004): 133-149. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242271244&partnerID=MN8TOARS.
    10.1016/j.bpc.2003.09.001
  171. Veiga, S.; Henriques, S.; Santos, N.C.; Castanho, M.. "Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level". Biochemical Journal 377 1 (2004): 107-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642494594&partnerID=MN8TOARS.
    10.1042/BJ20031350
  172. Veiga, A.S.; Santos, N.C.; Loura, L.M.S.; Fedorov, A.; Castanho, M.A.R.B.. "HIV fusion inhibitor peptide T-1249 is able to insert or adsorb to lipidic bilayers. Putative correlation with improved efficiency". Journal of the American Chemical Society 126 45 (2004): 14758-14763. http://www.scopus.com/inward/record.url?eid=2-s2.0-8844228894&partnerID=MN8TOARS.
    10.1021/ja0459882
  173. Santos, N.C.; Figueira-Coelho, J.; Martins-Silva, J.; Saldanha, C.. "Multidisciplinary utilization of dimethyl sulfoxide: Pharmacological, cellular, and molecular aspects". Biochemical Pharmacology 65 7 (2003): 1035-1041. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037379110&partnerID=MN8TOARS.
    10.1016/S0006-2952(03)00002-9
  174. Santos, N.C.; Silva, A.C.; Castanho, M.A.R.B.; Martins-Silva, J.; Saldanha, C.. "Evaluation of Lipopolysaccharide aggregation by light scattering spectroscopy". ChemBioChem 4 1 (2003): 96-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037415015&partnerID=MN8TOARS.
    10.1002/cbic.200390020
  175. Santos, N.C.; Prieto, M.; Castanho, M.A.R.B.. "Quantifying molecular partition into model systems of biomembranes: An emphasis on optical spectroscopic methods". Biochimica et Biophysica Acta - Biomembranes 1612 2 (2003): 123-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038392423&partnerID=MN8TOARS.
    10.1016/S0005-2736(03)00112-3
  176. Saldanha, C.; Santos, N.C.; Martins-Silva, J.. "Fluorescent probes DPH, TMA-DPH and C17-HC induce erythrocyte exovesiculation". Journal of Membrane Biology 190 1 (2002): 75-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042266862&partnerID=MN8TOARS.
    10.1007/s00232-002-1025-5
  177. Santos, N.C.; Figueira-Coelho, J.; Saldanha, C.; Martins-Silva, J.. "Biochemical, biophysical and haemorheological effects of dimethylsulphoxide on human erythrocyte calcium loading". Cell Calcium 31 4 (2002): 183-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035992044&partnerID=MN8TOARS.
    10.1054/ceca.2002.0271
  178. Santos, N.C.; Fernandes, M.X.J.J.; Castanho, M.A.R.B.. "Overcoming angular dependency when teaching light scattering using a spectrofluorometer: The molecular weights of latex beads". Journal of Chemical Education 76 9 (1999): http://www.scopus.com/inward/record.url?eid=2-s2.0-0040886162&partnerID=MN8TOARS.
  179. Fernandes, M.X.J.J.; Santos, N.C.; Castanho, M.A.R.B.. "Continuous particle size distribution analysis with dynamic light scatteringMAXAMPER: A regularization method using the maximum amplitude for the average error and the Lagrange's multipliers method". Journal of Biochemical and Biophysical Methods 36 2-3 (1998): 101-117. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031776218&partnerID=MN8TOARS.
    10.1016/S0165-022X(98)00002-5
  180. Santos, N.C.; Ter-Ovanesyan, E.; Zasadzinski, J.A.; Castanho, M.A.R.B.. "Reconstitution of phospholipid bilayer by an atomic force microscope tip [2]". Biophysical Journal 75 4 (1998): 2119-2120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031682589&partnerID=MN8TOARS.
  181. Santos, N.C.; Ter-Ovanesyan, E.; Zasadzinski, J.A.; Prieto, M.; Castanho, M.A.R.B.. "Filipin-induced lesions in planar phospholipid bilayers imaged by atomic force microscopy". Biophysical Journal 75 4 (1998): 1869-1873. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031690831&partnerID=MN8TOARS.
  182. Santos, N.C.; Prieto, M.; Castanho, M.A.R.B.. "Interaction of the major epitope region of HIV protein gp41 with membrane model systems. A fluorescence spectroscopy study". Biochemistry 37 24 (1998): 8674-8682. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032537597&partnerID=MN8TOARS.
    10.1021/bi9803933
  183. Santos, N.C.; Castanho, M.A.R.B.. "Erratum: (Biophysical Journal (1996) 71 (1641-1650))". Biophysical Journal 72 3 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-0031055305&partnerID=MN8TOARS.
  184. Castanho, MARB; Santos, NC; Loura, LMS. "Separating the turbidity spectra of vesicles from the absorption spectra of membrane probes and other chromophores". European Biophysics Journal With Biophysics Letters 26 3 (1997): 253-259.
    10.1007/s002490050078
  185. Santos, N.C.; Sousa, A.M.A.; Betbeder, D.; Prieto, M.; Castanho, M.A.R.B.. "Structural characterization of organized systems of polysaccharides and phospholipids by light scattering spectroscopy and electron microscopy". Carbohydrate Research 300 1 (1997): 31-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030988131&partnerID=MN8TOARS.
    10.1016/S0008-6215(97)00025-6
  186. Santos, N.C.; Prieto, M.J.E.; Morna-Gomes, A.; Betbeder, D.; Castanho, M.A.R.B.. "Structural characterization (shape and dimensions) and stability of polysaccharide/lipid nanoparticles". Biopolymers 41 5 (1997): 511-520. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031127551&partnerID=MN8TOARS.
    10.1002/(SICI)1097-0282(19970415)41:5<511::AID-BIP3>3.0.CO;2-P
  187. Santos, N.C.; Castanho, M.A.R.B.. "Teaching light scattering spectroscopy: The dimension and shape of tobacco mosaic virus". Biophysical Journal 71 3 (1996): 1641-1650. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029738097&partnerID=MN8TOARS.
Capítulo de livro
  1. Freire, João Miguel; Domingues, Marco M.; Matos, Joana; Melo, Manuel N.; Veiga, Ana Salomé; Santos, Nuno C.; Castanho, Miguel A. R. B.. "Quantifying molecular partition of charged molecules by Zeta-potential measurements". European Peptide Society, 2010.
  2. Domingues, Marco; Santos, Nuno C.. "Laser-light scattering approach to peptide–membrane interaction.". In Membrane-active peptides: methods and results on structure and function, 145-168. IUL Biotechnology, 2010.
    Publicado
  3. Castanho, Miguel A. R. B.; Prieto, Manuel J. E.; Betbeder, Didier; Santos, Nuno C.. "The Shape, Dimension and Organisation of Maltodextrins Gel Fragments with and without Associated Phospholipids". In Light Scattering and Photon Correlation Spectroscopy, 173-187. Springer Netherlands, 1997.
    Publicado • 10.1007/978-94-011-5586-1_15
Livro
  1. Santos, N.C.; Carvalho, F.A.. Preface. 2019.
  2. Lopes, C.S.; Carvalho, F.A.; Santos, N.C.. Atomic force microscopy: A tool for imaging, manipulating biomolecules, and quantifying single-molecule interactions in biological systems. 2017.
  3. Castanho, M.; Santos, N.C.. Preface. 2011.
Manual
  1. Quialheiro, A.; Miranda, André; Garcia Júnior, M.; Santos, N.C.; Camargo, A.; Correia-Neves, M.. Manual do projeto OITO: oficinas de inclusão tecnológica online. Portugal. 2021.
    Publicado • 10.21814/1822.74175
Poster em conferência
  1. Vieira, Tomás; Soares-Castro, Pedro; Gonçalves, Sónia; Santos, Nuno C.. Autor correspondente: Vieira, Tomás. "EXPLORING SILVER NANOSTARS AS ANTIBACTERIAL AGENTS AGAINST STAPHYLOCOCCUS AUREUS". Trabalho apresentado em Biophysics Festival, 2024.
  2. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina C.. "Circular RNAs in cardiovascular disease: Insights from a cardiac cell model". Trabalho apresentado em EMBO Workshop on The new cardiobiology, 2024.
  3. Lopes, Catarina S.; Carvalho, Filomena A.; Weinmüller, M.; Kessler, H.; Santos, Nuno C.. "avb3 integrin peptide inhibitors impact on fibrinogen-erythrocyte binding". Trabalho apresentado em XVIII Iberian Peptide Meeting, 2023.
  4. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Lourenço, Diogo M.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina C.. "Into the Heart of Cardiac Diseases: Lessons from a Cardiac Model". Trabalho apresentado em 13th EMBO Young Scientists¿ Forum, 2023.
  5. Lopes, Catarina S.; Melo, Ryan; Duarte, António; Nabais, Sofia; Freitas, Teresa; Gaspar, Ana Rita; Fonseca, Ana Mara; et al. "Erythrocyte adhesion and biomechanics on carotid artery disease patients". Trabalho apresentado em 3rd Portuguese Young Biophysicists¿ Meeting, Biophysics Festival 2023, 2023.
  6. Gabriel, André F.; Lopes, Catarina S.; Carvalho, A. Filomena; Vaz, Sandra H.; Santos, Nuno C.; Enguita, Francisco J.; Costa, Marina. "Sailing through the Surface to Unveil the Inner Workings of AC16 Cells: A Biophysical and Transcriptomic Expedition towards an Atrial Fibrillation cell model". Trabalho apresentado em XVI CAML · VI NeurULisboa PhD Students Meeting, 2023.
  7. Sarmento, Maria J.; Kohutova, Petra; Carvalho, Filomena A.; Hof, Martin; Santos, Nuno C.. "Unveiling the role of nuclear envelope lipids in human physiological aging". Trabalho apresentado em EMBO Young Scientists' Forum, 2023.
  8. Lopes, Catarina S.; Laborinho-Pronto, A.C.; Vasco A. Conceição; Marta Gromicho; Santos, Nuno C.; de Carvalho, Mamede; Carvalho, Filomena A.. "Evaluation of morphological and elastic changes on erythrocytes and y' fibrinogen as possible predictors of survival in Amyotrophic Lateral Sclerosis". Trabalho apresentado em 8th International Iberian Biophysics congress, 2022.
  9. Sarmento, Maria J.; Pais do Amaral, Constança; Santos, Nuno C.. "Deciphering the lipid composition of the human nuclear envelope during healthy aging". Trabalho apresentado em Membrane Biophysics Meeting, 2022.
  10. M. Silva, Patrícia; da Silva, Inês V.; Sarmento, Maria J.; Filomena A. Carvalho; Soveral, Graça; Santos, Nuno C.. "AQP3 and AQP5 silencing promotes changes in cell-cell adhesion and biomechanical properties of pancreatic cancer cells". Trabalho apresentado em 20th IUPAB Congress, 45th Annual SBBf Meeting, and 50th Annual SBBq Meeting, 2021.
  11. Martins, Ana S.G.; Reis, S.D.; Ruxandra Baboi; Cortinhas, João; Domingues, M.M.; Santos, N.C.; Santos, S.D.; Pêgo, Ana Paula; Moreno, P.M.D.. Autor correspondente: Moreno, P.M.D.. "Aptamer-functionalized tetrahedral DNA nanostructures aiming at neuronal targeting". Trabalho apresentado em 1st Symposium on Oligonucleotide Thecnologies & Therapeutics at Portugal, 2021.
  12. Martins, Ana S.G.; Santos, Sofia Duque; Marco M. Domingues; Santos, Nuno C.; Pêgo, Ana P.; Moreno, Pedro M. D.. Autor correspondente: Moreno, Pedro M. D.. "Neuronal Targeted Nucleic-Acid Nanostructures aiming at Neurotherapies". Trabalho apresentado em World Biomaterials Congress 2020 (WBC 2020), 2020.
  13. Sabino, João C.; Sridhara, Sreerama C.; Abreu, Patrícia L.; Domingues, Marco M.; Santos, Nuno C.; Grosso, Ana Rita; de Almeida, Sérgio F.. "Epigenetic determinants of transcription-coupled genomic instability". Trabalho apresentado em Trends in Genome Integrity & Chromosome Dynamics, 2020.
  14. Silva, Patrícia; Peter Eaton; Santos, Nuno C.. "The interaction of viral fusion inhibitor lipopeptides with biomembranes is improved by PEG linker length". Trabalho apresentado em 4th Meeting of the College of Chemistry of ULisboa (4ECQUL), 2019.
  15. Lopes, Catarina S.; Guedes, Ana Filipa; Fonseca, Ana Catarina; Ferro, José M. ; Santos, Nuno C.; Carvalho, Filomena A.. "Fibrinogen-erythrocyte binding as a new cerebrovascular risk factor on stroke patients". Trabalho apresentado em XIII PhD Students Meeting,, 2019.
  16. L. Alves; F. A. Carvalho; C. Lopes; Maria I. L. Soares; Teresa M. V. D. Pinho e Melo; Santos, N.C.; O. V. Vieira. "Lysosomal dysfunction in vascular smooth muscle cells plays a role in atherosclerosis". Trabalho apresentado em Cell Dynamics: Organelle-Cytoskeleton Interface, 2019.
  17. Silva, Patrícia; Augusto, Marcelo T.; Marta C. Marques; Porotto, Matteo; Moscona, Anne; Santos, Nuno C.. "Biophysical characterization of lipid-tagged peptides as fusion inhibitors for respiratory viruses". Trabalho apresentado em 3rd Meeting of the CQUL (3ECQUL), 2018.
  18. Lopes, Catarina S.; Pronto-Laborinho, Ana Catarina; Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Changes on elasticity and morphology of erythrocytes from amyotrophic lateral sclerosis patients". Trabalho apresentado em XII PhD Students Meeting, 2018.
  19. Lopes, Catarina S.; Laborinho-Pronto, A.C.; de Carvalho, Mamede; Santos, Nuno C.; Carvalho, Filomena A.. "Using AFM to study erythrocytes morphology and elasticity on Amyotrophic Lateral Sclerosis". Trabalho apresentado em Bioimaging 2016, 5th International Symposium in Applied Bioimaging – Disease in Focus, 2016.
  20. Lopes, Catarina S.; Guedes, Ana Filipa; Nogueira, J. B.; Moreira, C.; Carvalho, Filomena A.; Santos, Nuno C.. "Erythrocyte-erythrocyte adhesion promoted by fibrinogen in Essential Arterial Hypertension patients". Trabalho apresentado em 5th International Iberian Biophysics Congress, 2016.
Pré-impressão
  1. Sabino, João C.; de Almeida, Madalena R.; Abreu, Patricia L.; Ferreira, Ana M.; Domingues, Marco M.; Santos, Nuno C.; Azzalin, Claus; Grosso, Ana R.; de Almeida, Sérgio F.. "Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops". 2021. http://dx.doi.org/10.1101/2021.04.26.441414.
    10.1101/2021.04.26.441414
Resumo em conferência
  1. Sarmento, Maria J.; Kohutova, Petra; Carvalho, Filomena A.; Hof, Martin; Santos, Nuno C.. "Deciphering the role of nuclear envelope lipids in human healthy aging". Trabalho apresentado em EBSA Congress, Stockholm, 2023.
    Publicado
  2. Martins, Ana S.G.; Reis, S.D.; Ruxandra Baboi; Cortinhas, João; Domingues, M.M.; Santos, N.C.; Santos, Sofia Duque; Pêgo, Ana Paula; Moreno, P.M.D.. Autor correspondente: Moreno, P.M.D.. "Nucleic acid-based nanostructures functionalized with neurotrophin-mimetic aptamer aiming at neuronal targeting". Trabalho apresentado em 31st Conference of the European Society for Biomaterials (ESB), Porto, 2021.
  3. Alves, Carla S.; Melo, Manuel N.; Franquelim, Henri G; Ferre, Rafael; Planas, Marta; Feliu, Lidia; Bardají, Eduard; et al. "Relation between Escherichia coli killing and charge neutralization by the antimicrobial peptides BP100 and pepR". Trabalho apresentado em Encontro Peptídico Ibérico / Iberian Peptide Meeting, Lisbon, 2010.
    Publicado
Tese / Dissertação
  1. MATINHOS, Renata Pereira das Neves Baptista. "A new antiviral strategy for pandemic and seasonal influenza". Mestrado, 2024. http://hdl.handle.net/10362/178366.
  2. Guedes, Ana Filipa. "Molecular characterization of the fibrinogen-erythrocyte interaction as a cardiovascular risk". Doutoramento, 2018. http://hdl.handle.net/10451/36920.
  3. Silva, Patrícia Morgado da. "Broad-spectrum antiviral peptides against respiratory viruses". Mestrado, 2016. http://hdl.handle.net/10451/24665.
  4. Rodrigues, Margarida Filipe Dias. "Molecular determinants of the cellular internalization of crotamine-derived peptides". Doutoramento, 2014. http://hdl.handle.net/10451/11459.
  5. Matos, Pedro, 1985-. "Shedding light on enveloped viruses entry and its inhibition using optical techniques". Doutoramento, 2013. http://hdl.handle.net/10451/11260.
  6. Carvalho, Filomena A., 1976-. "Studying single-molecule protein interactions and its biological and biomedical applications by AFM-based force spectroscopy". Doutoramento, 2012. http://hdl.handle.net/10451/7426.
  7. Domingues, Marco André Manso, 1985-. "Study of the mechanism of action of the antimicrobial peptide rBPI21 in gram-negative bacteria". Doutoramento, 2012. http://hdl.handle.net/10451/8633.
  8. Franquelim, Henri Girão,1984-. "The role of lipid membranes in the mechanism of action of sifuvirtide and other HIV-1 fusion inhibitors". Doutoramento, 2012. http://hdl.handle.net/10451/7113.
  9. Faustino, André Filipe da Costa. "Molecular level evaluation of the dengue virus capsid protein role(s) on the virus life cycle". Mestrado, 2011. http://hdl.handle.net/10451/8945.

Outros

Outra produção
  1. Complexation and full characterization of the tretinoin and dimethyl-ßeta-cyclodextrin complex. Abstract. The aim of this work is to prepare tretinoin/dimethyl-beta-cyclodextrin complexes and fully characterize them through various analytical techniques. According to the phase solubility studies performed, the equilibrium for maximum complexation is reached in about 8 days presenting an AL-type diagram (soluble complexes) corresponding mainly to 1:1 stoichiometry (Ks=13,600 M-1), although th. 2011. Ascenso, Andreia; Guedes, Rita; Bernardino, Raul; Diogo, Herminio; Carvalho, Filomena A.; Santos, Nuno C.; Silva, Aida M.; Marques, Helena Cabral. http://dx.doi.org/10.1208/s12249-011-9612-.
    http://dx.doi.org/10.1208/s12249-011-9612-
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017 - 2023/03/10 Flavivirus capsid proteins interaction with host lipid systems and viral RNA
Coorientador
 Programa Doutoral do Centro Académico de Medicina de Lisboa (ramo de Medicina; ramo de Ciências Biomédicas; ramo de Ciências e Tecnologias da Saúde) (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2020/10/08 Design and mechanistic characterization of novel antimicrobial and anticancer peptides
Coorientador
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2020/04/17 Desenho racional de peptídeos análogos ao neuropeptídeo Y para o tratamento da obesidade
Coorientador de Beatriz Torres Meneguetti Mandruzzato
 Biotecnologia (Doutoramento)
Universidade Católica Dom Bosco, Brasil
2014 - 2018/12/18 Enveloped viruses - a peptide inhibition strategy
Orientador de Marcelo Alexandre da Costa Tavares Augusto
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2018/10/12 Characterization of enveloped viruses inhibition by 25-hydroxycholesterol at the membrane level
Orientador de Bárbara Sofia Lopes Gomes
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2018/07/11 Molecular characterization of the fibrinogen-erythrocyte interaction as a cardiovascular risk
Orientador de Ana Filipa Barata Duarte Guedes
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2016/07/04 Dengue virus capsid protein structural and functional studies: a gateway for possible dengue inhibition strategies
Orientador de André Filipe da Costa Faustino
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2014/03/03 Molecular determinants of the celular internalization of crotamine-derived peptides
Orientador de Margarida Filipe Dias Rodrigues
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2013/07/10 Shedding light on enveloped viruses entry and its inhibition using optical techniques
Orientador de Pedro Miguel Baptista de Matos
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/12/19 Study of the mechanism of action of the antimicrobial peptide rBPI21 in Gram-negative bacteria
Orientador de Marco André Manso Domingues
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/07/12 The role of lipid membranes in the mechanism of action of sifuvirtide and other HIV-1 fusion inhibitors
Coorientador de Henri Girão Franquelim
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2012/07/03 Studying single-molecule protein interactions and its biological and biomedical applications by AFM-based force spectroscopy
Orientador de Filomena Maria Dias Almeida Carvalho Arede
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal

Membro de associação

Nome da associação Tipo de participação
2019/09/04 - Atual Ambassador of the Biophysical Society (USA) Ambassador
2019/07/23 - Atual Member of the Executive Committee of the European Biophysical Societies' Association (EBSA) Member
2018/03/27 - Atual National Representative of Portugal at the European Peptide Society National Representative
2017/04/01 - Atual Presidente da Mesa da Assembleia do Colégio de Química da Universidade de Lisboa Presidente da Mesa da Assembleia
2015/05/13 - 2021/11/05 President of the Portuguese Biophysical Society President
2008/10/01 - 2015/05/13 Treasurer of the Portuguese Biophysical Society Treasurer
Distinções

Prémio

2023 ULisboa / Caixa Geral de Depósitos Prize (Biology, Biological Engineering, Biochemistry and Biotechnology)
Universidade de Lisboa, Portugal

Caixa Geral de Depositos, Portugal
2017 ULisboa / Caixa Geral de Depósitos Prize (Biology, Biological Engineering, Biochemistry and Biotechnology)
2005 Dr. José Luís Champalimaud Prize (Applied Research and Technologies area)
2004 Dr. José Luís Champalimaud Prize (Basic Research area)
2001 Programa Gulbenkian de Estímulo à Investigação
Fundação Calouste Gulbenkian, Portugal