???global.info.a_carregar???
Henrique O. Duarte has an interntional PhD in Molecular and Cellular Biotechnology Applied to Health Sciences (ICBAS/FFUP, University of Porto, 2020), funded by FCT and the European Association for Cancer Research (EACR). Host Institution: Glycobiology in Cancer group of the Institute for Research and Innovation in Health, University of Porto (i3S) and the Center for Proteomics and Metabolomics of the Leiden University Medical Center (CPM/LUMC), Leiden, The Netherlands. During his PhD, Henrique has comprehensively dissected the glycosylation profile of the ErbB2 oncogenic receptor in gastric cancer and identified glycan-mediated pathways of molecular resistance to the clinically implemented trastuzumab therapeutic agent. Using translational multidisciplinary approaches, including genetically glycoengineered tumor cell models and Mass spectrometry-guided workflows for glycan structural elucidation, his research work has provided clinically relevant insights on the mechanistic role played by glycans on ErbB2-positive unresectable gastric cancer. Henrique's PhD research work has been acknowledged, funded and awarded by multiple renowned Institutions of Biomedical and Cancer Research (including the European Society for Medical Oncology (ESMO), The European Molecular Biology Laboratory (EMBL), the European Association for Cancer Research (EACR), the International Glycoconjugate Organization (IGO), the Utrecht University, and Portuguese Society for Human Genetics). Currently: Junior Researcher and Project Leader at i3S, where he is dissecting the role played by cancer-associated glycosylation signatures in the emergence of molecular resistance to both conventional and targeted therapies in the advanced gastric cancer setting. His work has selected for presentation in multiple international scientific meetings related to Cancer Biology, and has been awarded as both the poster and oral communication (including the Porto Cancer Meeting). He has co-authored 15 publications in internationally recognized peer-reviewed journals (including high profile publications in Trends in Cancer, Oncogene, Cancer Cell, Molecular Aspects of Medicine, FEBS Letters, Plant Biotechnology journal), and 3 book chapters edited by prestigious scientific publishers (Nova Publishers, Wiley and Elsevier). He has secured funding as PI in two competitive calls: 3rd edition "Prémio Francisco Augusto da Fonseca Dias e Maria José Melenas da Fonseca para Jovens Investigadores" (LOGIC 2021, 50.000€), and an FCT-funded project (EMERGENCE 2022.04138.PTDC, 50.000€). He served as Co-PI of an FCT-funded project (GlycOrganoid 2021, 50.000€), and has integrated the teams of multiple FCT- and pharmaceutical industry-funded projects (~1.5M€). He currently manages a team composed by one Research Trainee, one MSc student, and he co-supervises one MSc student. He has integrated the organizing and scientific committees of national and international scientific meetings (including the IV BiotechHealth Annual Symposium (Porto, 2017), EU-funded COST Action Young Researchers Meeting (Iasi, 2023) and the 15th Jenner Glycobiology and Medicine Symposium (Porto, 2023)). He serves as a reviewer for high impact scientific journals (Molecular Oncology, Oncotarget, American Journal of Cell Physiology, Cancers, iScience, Frontiers in Oncology and Frontiers in Cell and Developmental Biology). Previous studies: Integrated Master in Bioengineering, with a specialization in Molecular Biotechnology (2014, FEUP/ICBAS) awarded by the University of Porto, for which he was awarded with a Merit Scholarship for Exceptional Achievement as a student of the University of Porto by the Portuguese Ministry of Education (3rd best student of the 2009-2014 class). Research intern at the Department of Infectious Diseases of the National Health Institute (2012). Research intern at the Structural Biology Department of the Vrije University Amsterdam, The Netherlands (ERASMUS international mobility programme, 2013).
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Henrique Matos Fernandes de Oliveira Duarte

Nomes de citação

  • Duarte, Henrique O.

Identificadores de autor

Ciência ID
CE14-D4A9-61C8
ORCID iD
0000-0001-8641-8368
Google Scholar ID
https://scholar.google.com/citations?user=N8wMNcYAAAAJ&hl=en&oi=ao
Researcher Id
rid75594
Scopus Author Id
57193257827

Endereços de correio eletrónico

  • hduarte@ipatimup.pt (Profissional)

Telefones

Telefone
  • (+351) 22 607 490 Ext.: 6067 (Profissional)

Moradas

  • Rua Alfredo Allen 208, 4200-235, Porto, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2020/09/21
Concluído
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Cracking the ErbB2 Sugar Code in Gastric Cancer: A Bitter Sweet Functional Target " (TESE/DISSERTAÇÃO)
 NA
2018/09/16 - 2018/09/21
Concluído
 Genome Engineering: CRISPR / Cas (Curso de Especialização Tecnológica)
EMBL Heidelberg Genomics Core Facility, Alemanha
2017/07/17 - 2017/07/21
Concluído
 Utrecht Summer School - Molecular Mechanisms in Cancer (Curso de Especialização Tecnológica)
Hubrecht Institute, Países Baixos

Universiteit Utrecht Faculteit Geneeskunde, Países Baixos
2016/09 - 2016/09
Concluído
 FELASA C (Federation of European Laboratory Animal Science ASsociations) training in Laboratory Animal Science (Curso de Especialização Tecnológica)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/07/14
Concluído
 Bioengenharia (Mestrado)
Especialização em Área de especialização: Biotecnologia Molecular
Universidade do Porto Faculdade de Engenharia, Portugal
"Exploiting the interplay between c.-Myc and novel micrornas in prostate carcinogenesis" (TESE/DISSERTAÇÃO)
 18.06 (out of 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/06/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/09/22 - 2021/05/31 Pós-doutorado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/01/01 - 2015/12/31 Estagiário de Investigação (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/01/01 - 2020/09/21 PhD Student (enrolled in the BiotechHealth International PhD Programme) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013/09/15 - 2014/09/15 Master Student Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2013/02/01 - 2013/07/31 Research Intern (curricular internship within the Integrated Master in Bioengineering) Vrije Universiteit Amsterdam, Países Baixos
Vrije Universiteit Amsterdam, Países Baixos
2012/01/01 - 2012/12/31 Research Intern (curricular internship within the Integrated Master in Bioengineering) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Projetos

Bolsa

Designação Financiadores
2020/06/01 - Atual Norway-Portugal European Economic Agreement (EEA)
----
Bolseiro de Cientista Convidado
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Oslo universitetssykehus, Noruega
EEA Grants
Em curso
2023/02/01 - 2024/07/31 EMERGENCE - ErbB2 Molecular Heterogeneity Drives Glycan-Mediated Trastuzumab Resistance
2022.04138.PTDC
10.54499/2022.04138.PTDC
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/05/01 - 2019/12/31 Glycosylation of Tyrosine Kinase Receptors as Novel Biomarkers for Targeted Therapy
NORTE-01-0145-FEDER-000029
Bolseiro de Doutoramento
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluído
2016/03/01 - 2018/02/28 Glycosylation of Tyrosine Kinase Receptors in Gastric Cancer: Novel Biomarkers for Targeted Therapy
441.00 DAAD
Bolseiro de Doutoramento
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia

Deutscher Akademischer Austauschdienst
Concluído
2015/10/01 - 2015/12/31 Glycosylation of Cellular Receptors in Cancer
------
Bolseiro de Integração na Investigação
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Merck KGaA
Concluído
2013/06/01 - 2015/09 Zinc-finger nuclease-glycoengineered SimpleCell lines for characterization of the O-glycoproteome of cancer cells.
PTDC/BBB-EBI/0786/2012
Bolseiro de Integração na Investigação
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/04/01 - 2014/07/31 Discovery of novel microRNA genes epigenetically down-regulated in prostate cancer
EXPL/BIM-ONC/0556/2012
Bolseiro de Mestrado
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2022/01/01 - Atual LOGIC - Glycoform-Specific Detection of ErbB2 in Gastric Cancer: Improving Patient Stratification and Redefining Eligibility for Anti-ErbB2 Targeted Therapy
-----
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular
Em curso
2023/02/01 - 2029/01/31 CHOICE - Cracking tHe erbb2 sugar cOde In CancEr: towards prognostic and therapeutic stratificationCracking the ErbB2 Sugar Code in Cancer: Towards Prognostic and Therapeutic Stratification
2022.00943.CEECIND/CP1735/CT0017
10.54499/2022.00943.CEECIND/CP1735/CT0017
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2024/12/31 GLYCOTARGET. A NEW FRONTIER IN EXTRACELLULAR VESICLE-MEDIATED CANCER IMMUNOMODULATION<br>
PTDC/MEC-ONC/0491/2021
10.54499/PTDC/MEC-ONC/0491/2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Instituto de Astrofísica e Ciências do Espaço, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2024/12/31 SweetKiller: Monosaccharide analogues as novel therapeutic agents to block glycan-driven cancer cell metastasis.
PTDC/MED-QUI/2335/2021
10.54499/PTDC/MED-QUI/2335/2021
Instituto de Astrofísica e Ciências do Espaço, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2023/12/31 Glycan-defined organoids as gastric cancer avatars for patient stratification and prediction of therapeutic response
EXPL/BTM-ORG/1450/2021
10.54499/EXPL/BTM-ORG/1450/2021
Co-Investigador Responsável (Co-IR)
Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/07/01 - 2020/03/31 CELLULAR GLYCOENGINEERING FOR EVALUATION OF POST-TRANSLATIONAL MODIFICATIONS OF RECEPTORS IN CANCER: THERAGNOSTIC APPLICATIONS
PTDC/BBB-EBI/0567/2014
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 Instituto de Investigação e Inovação em Saúde
UID/BIM/04293/2019
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto de Astrofísica e Ciências do Espaço, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2017/01/01 - 2019/12/31 Glyco Tech: Using glycoengineered Cell Lines as Biotechnological Tools to Unravel Resistance Mechanisms in Cancer Therapy
PD/BD/128407/2017
Instituto de Investigaciones Biomédicas Sols-Morreale, Espanha
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Duarte, Henrique O.. Autor correspondente: Duarte, Henrique O.. "HER2 and PD-L1 Expression in Gastric and Gastroesophageal Junction Cancer: Insights for Combinatorial Targeting Approaches". Cancers 16 6 (2024): 1227. https://www.mdpi.com/2072-6694/16/6/1227.
    Acesso aberto • Publicado • 10.3390/cancers16061227
  2. Izadi, Shiva; Gumpelmair, Simon; Coelho, Pedro; Duarte, Henrique O.; Gomes, Joana; Leitner, Judith; Kunnummel, Vinny; et al. "Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding". Plant Biotechnology Journal (2023): https://onlinelibrary.wiley.com/doi/10.1111/pbi.14260.
    Acesso aberto • Publicado • 10.1111/pbi.14260
  3. Costa-Barbosa, Augusto; Ferreira, Diogo; Pacheco, Maria Inês; Casal, Margarida; Duarte, Henrique Oliveira; Gomes, Catarina; Barbosa, Ana Margarida; et al. "Candida albicans chitinase 3 with potential as a vaccine antigen: Production, purification and characterisation". Biotechnology Journal (2023): 2300219. https://onlinelibrary.wiley.com/doi/full/10.1002/biot.202300219.
    Acesso aberto • Publicado • 10.1002/biot.202300219
  4. Duarte, Henrique O.; Reis, Celso A.; Gomes, Joana. "Insights on ErbB glycosylation – contributions to precision oncology". Trends in Cancer (2022): https://www.cell.com/trends/cancer/fulltext/S2405-8033(22)00039-5.
    10.1016/j.trecan.2022.02.003
  5. Francisca Diniz; Pedro Coelho; Henrique O. Duarte; Bruno Sarmento; Celso A. Reis; Joana Gomes. "Glycans as Targets for Drug Delivery in Cancer". Cancers (2022): https://doi.org/10.3390/cancers14040911.
    10.3390/cancers14040911
  6. Abrantes, Rafaela; Duarte, Henrique O.; Gomes, Catarina; Wälchli, Sébastien; Reis, Celso A.. "CAR-Ts: New Perspectives in Cancer Therapy". FEBS Letters 596 4 (2022): 403-416. https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14270.
    Acesso aberto • Publicado • 10.1002/1873-3468.14270
  7. Magalhães, Ana; Duarte, Henrique O.; Reis, Celso A.. "The role of O-glycosylation in human disease". Molecular Aspects of Medicine 79 (2021): 100964. https://www.sciencedirect.com/science/article/abs/pii/S0098299721000248#:~:text=O%2Dglycans%20are%20key%20modulators,pathogen%20interplay%20and%20immune%20response.&text=Aberrant%20cellular%20O%2Dglycosylation%20promotes%20oncogenic%20signaling%20and%20tu.
    Publicado • 10.1016/j.mam.2021.100964
  8. Duarte, Henrique O.; Rodrigues, Joana G.; Gomes, Catarina; Hensbergen, Paul J.; Ederveen, Agnes L. Hipgrave; de Ru, Arnoud H.; Mereiter, Stefan; et al. "ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab". Oncogene 40 21 (2021): 3719-3733. https://www.nature.com/articles/s41388-021-01801-w.
    Publicado • 10.1038/s41388-021-01801-w
  9. Rodrigues, Joana G.; Duarte, Henrique O.; Gomes, Catarina; Balmaña, Meritxell; Martins, Álvaro M.; Hensbergen, Paul J.; de Ru, Arnoud H.; et al. "Terminal a2,6-sialylation of epidermal growth factor receptor modulates antibody therapy response of colorectal cancer cells". Cellular Oncology 44 4 (2021): 835-850. https://link.springer.com/article/10.1007%2Fs13402-021-00606-z.
    Acesso aberto • Publicado • 10.1007/s13402-021-00606-z
  10. Rodrigues, Joana G.; Duarte, Henrique O.; Reis, Celso A.; Gomes, Joana. "Aberrant protein glycosylation in cancer: implications in targeted therapy". Biochemical Society Transactions 49 2 (2021): 843-854. https://portlandpress.com/biochemsoctrans/article-abstract/49/2/843/228064/Aberrant-protein-glycosylation-in-cancer?redirectedFrom=fulltext.
    Publicado • 10.1042/bst20200763
  11. Leão, Beatriz; Wen, Xiaogang; Duarte, Henrique O.; Gullo, Irene; Gonçalves, Gilza; Pontes, Patrícia; Castelli, Claudia; et al. "Expression of Thomsen–Friedenreich Antigen in Colorectal Cancer and Association with Microsatellite Instability". International Journal of Molecular Sciences 22 3 (2021): 1340. https://www.mdpi.com/1422-0067/22/3/1340.
    Acesso aberto • Publicado • 10.3390/ijms22031340
  12. Duarte, Henrique O.; Gomes, Joana; Machado, José C.; Reis, Celso A.. "Gastric cancer: Basic aspects". Helicobacter 23 (2018): e12523. https://onlinelibrary.wiley.com/doi/epdf/10.1111/hel.12523.
    Publicado • 10.1111/hel.12523
  13. Duarte, H.O.; Balmaña, M.; Mereiter, S.; Osório, H.; Polónia, A.; Santos, L.L.; Gomes, J.; Reis, C.A.. "PO-174 ErbB2 glycosylation landscape in gastric cancer cells: a novel functional target?". ESMO Open 3 (2018): A295. https://www.esmoopen.com/article/S2059-7029(20)31742-7/fulltext#relatedArticles.
    Acesso aberto • Publicado • 10.1136/esmoopen-2018-eacr25.696
  14. Barros-Silva D; Costa-Pinheiro P; Duarte H; Sousa EJ; Evangelista AF; Graça I; Carneiro I; et al. "MicroRNA-27a-5p regulation by promoter methylation and MYC signaling in prostate carcinogenesis.". Cell death & disease 9 167 (2018): https://www.nature.com/articles/s41419-017-0241-y.
    Acesso aberto • Publicado • 10.1038/s41419-017-0241-y
  15. Duarte, H.O.; Balmaña, M.; Mereiter, S.; Osório, H.; Gomes, J.; Reis, C.A.. "Gastric cancer cell glycosylation as a modulator of the ErbB2 oncogenic receptor". International Journal of Molecular Sciences 18 11 (2017): 2262-2280. https://www.mdpi.com/1422-0067/18/11/2262.
    Acesso aberto • Publicado • 10.3390/ijms18112262
  16. Magalhães, Ana; Duarte, Henrique O.; Reis, Celso A.. "Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis". Cancer Cell 31 6 (2017): 733-735. https://www.cell.com/cancer-cell/fulltext/S1535-6108(17)30208-8.
    Acesso aberto • Publicado • 10.1016/j.ccell.2017.05.012
  17. Duarte, H.O.; Freitas, D.; Gomes, C.; Gomes, J.; Magalhães, A.; Reis, C.A.. "Mucin-type O-glycosylation in gastric carcinogenesis". Biomolecules 6(3) 33 (2016): E33. https://www.mdpi.com/2218-273X/6/3/33.
    Acesso aberto • Publicado • 10.3390/biom6030033
Capítulo de livro
  1. Magalhães, Ana; Duarte, Henrique O.; Reis, Celso A.. "Glycans and Cancer". In Encyclopedia of Cell Biology, 373-384. Amsterdam, Países Baixos: Elsevier, 2023.
    10.1016/b978-0-12-821618-7.00019-5
  2. Duarte, Henrique O.. "Targeting Carbohydrates in Cancer: Analytical and Biotechnological Tools". In Carbohydrate-based Therapeutics and Diagnostics, editado por Luigi Lay; Roberto Adamo. Hoboken, Estados Unidos: WILEY-VCH GmbH, 2022.
    Publicado
  3. Duarte, Henrique O.. "Glycans as Gastrointestinal Cancer Biomarkers: Old and New Diagnostic, Predictive and Stratifying Tools". In Glycome: The Hidden Code in Biology, 231-246. New York, Estados Unidos: Nova Science Publishers, 2021.
    Publicado
Poster em conferência
  1. Duarte, Henrique O.. "ST6Gal1 Targets the ErbB2 Ectodomain in a Site-Specific Manner and Regulates Gastric Cancer Cell Sensitivity to Trastuzumab". Trabalho apresentado em EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, 2022.
  2. Duarte, Henrique O.. "a2,6-Linked Sialic Acid Regulates ErbB2 Biology and Gastric Cancer Cell Response to Trastuzumab in a Glycosite-Specific Manner". Trabalho apresentado em 25th Symposium on Glycoconjugates, 2019.
  3. Duarte, Henrique O.. "Unravelling ErbB2 Glycosylation Signature in Gastric Cancer Cells". Trabalho apresentado em 29th International Carbohydrate Symposium, 2018.
  4. Duarte, Henrique O.. "Deciphering ErbB2 Glycosylation Profile in Gastric Cancer Cells". Trabalho apresentado em 2nd edition of the practical course - From Protein Structure to Biological Function through Interactomics: An Integrated View, 2018.
  5. Duarte, Henrique O.. "Phosphorylation of the Estrogen Receptor Alpha in Breast Cancer: The Hunt for the Elusive Kinase". Trabalho apresentado em 10th edition of the Young European Scientist (YES) Meeting, 2015.
Pré-impressão
  1. Costa, Ana F.; Senra, Emanuel; Campos, Diana; Faria-Ramos, Isabel; Santos-Ferreira, Liliana; Lamas, Sofia; Gomes, Joana; et al. "Monensin as potential drug for treatment of SLeX-positive tumors". 2024. http://dx.doi.org/10.1101/2024.03.11.24304048.
    10.1101/2024.03.11.24304048
Tese / Dissertação
  1. "Cracking the ErbB2 Sugar Code in Gastric Cancer: A Bitter Sweet Functional Target". Doutoramento, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2021. https://repositorio-aberto.up.pt/handle/10216/129345.
  2. Duarte, Henrique O.. "Exploiting the Interplay between c-Myc and Novel MicroRNAs in Prostate Carcinogenesis". Mestrado, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2014. https://sigarra.up.pt/reitoria/en/pub_geral.pub_view?pi_pub_base_id=31436.

Propriedade Intelectual

Pedido provisório de patente
  1. 2021. "ErbB2 site-specific alpha2,6-sialylation as a biomarker of gastric cancer cell sensitivity to trastuzumab".
    Protegido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/01/17 ErbB2 Glycosylation in Gastric Cancer: Unravelling the Bittersweet Road to Molecular Resistance 7th Iberian Carbohydrate Meeting
Real Sociedad Española de Química (RSEQ) and Sociedade Portuguesa de Química (SPQ) (Sitges, Espanha)
2023/10 ErbB2 Glycosylation in Gastric Cancer: Unraveling the Bittersweet Road to Molecular Resistance 10th Anniversary of the BiotechHealth International Doctoral Program
Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (ICBAS) (Porto, Portugal)
2023/06/15 ST6Gal1 Modifies ErbB2 Trastuzumab-Binding Domain in a Site-Specific Manner to Support Molecular Resistance to Trastuzumab 15th Jenner Glycobiology and Medicine Symposium
Royal Society of Medicine; Institute for Research and Innovation in Health, University of Porto (i3S) (Porto, Portugal)
2023/05/11 Cracking the ErbB2 Sugar Code in Gastric Cancer – A Bittersweet Functional Target. 29th Porto Cancer Meeting – Glycosylation in Tumor Biology and Its Clinical Implications: The Cancer Bittersweet Portrait
Institute for Research and Innovation in Health, University of Porto (i3S) (Porto, Portugal)
2023/04/21 ST6Gal1 Modifies ErbB2 Trastuzumab-Binding Domain in a Site-Specific Manner to Support Molecular Resistance to Trastuzumab International Meeting of Young Researchers 2023 - Sour Turned Sweet: Glycans Bridging Technology and Precision Medicine
COST Actions 18103 INNOGLY and 18132 GLYCONanoPROBES (Ia¿i, Roménia)
2022/11/19 ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab 26th Annual Meeting of the Portuguese Society of Human Genetics (SPGH)
Sociedade Portuguesa de Genética Humana (SPGH) (Coimbra, Portugal)
2021/10/14 Cracking the ErbB2 Sugar Code in Gastric Cancer - A Bitter Sweet Functional Target II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer
ASPIC-ASEICA
2021/09/27 Cracking the ErbB2 Sugar Code in Gastric Cancer - A Bitter Sweet Functional Target INNOGLY-ECI-WG3-2021: Young Glyco-Scientists on stage
INNOGLY
2019/11/28 Cracking the ErbB2 Sugar Code in Gastric Cancer - A Novel Biomarker for the Prediction of Trastuzumab Therapeutic Response Institute for Research and Innovation in Health (i3S) Annual Meeting
Institute for Research and Innovation in Health (i3S), University of Porto (Póvoa de Varzim, Portugal)
2019/09/03 Unraveling the ErbB2 Glycan Repertoire in Gastric Cancer - A Bitter Sweet Functional Target 13th International Meeting of the Portuguese Carbohydrate Group – GLUPOR 13
Sociedade Portuguesa de Química (Porto, Portugal)
2019/05/02 Cracking the ErbB2 Sugar Code in Gastric Cancer - A Bitter Sweet Functional Target 26th Porto Cancer Meeting – The Cancer Ecosystem: from Research to Pathology & Treatment.
Institute for Research and Innovation in Health (Porto, Portugal)
2018/11/30 ErbB2 Glycosylation in Gastric Cancer – A Bitter Sweet Functional Target Institute for Research and Innovation in Health (i3S) Annual Meeting
Institute for Research and Innovation in Health (i3S), University of Porto (Póvoa de Varzim, Portugal)
2018/07/14 Unravelling ErbB2 Glycosylation Signature in Gastric Cancer Cells 29th International Carbohydrate Symposium
International Carbohydrate Organization (Lisboa, Portugal)
2018/05/30 Glycosylation Landscape in Gastric Cancer Cells – A Novel Functional Target? 1st PhDay at i3S – From Bench to Stage, From Desk to Forum
Institute for Research and Innovation in Health (i3S), University of Porto (Porto, Portugal)
2017/09/11 Deciphering ErbB2 Glycosylation Profile in Gastric Cancer Cells 12ª Reunião do Grupo de Glúcidos - GLUPOR12
Sociedade Portuguesa de Química (Aveiro, Portugal)
2015/05/14 Phosphorylation of the Estrogen Receptor Alpha in Breast Cancer: The Hunt for the Elusive Kinase 8th edition of the Meeting of Young Researchers of the University of Porto (IJUP)
University of Porto (Porto, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/09/01 - 2024/11/11 Combining Mass Spectrometry Analytical Workflows and Automated Image Analysis to Uncover the Spatial Heterogeneity of Tumor-Associated Glycan Networks in Gastric Cancer
Orientador de Rodrigo Gregório Samico
 Master's Degree in Bioinformatics and Computational Biology (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2023/01/01 - 2024/06/06 Unravelling the impact of Heparan Sulfate profiles in Receptor Tyrosine Kinase activation using gastric cancer as model
Coorientador
 Master's Degree in Medicine and Molecular Oncology (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/04/01 - 2023/09/15 EMERGENCE - ErbB2 Molecular Heterogeneity Drives Glycan-Mediated Trastuzumab Resistance
Orientador
 Research Fellowship (Outra)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/02/01 - 2023/07/31 Unraveling the ErbB2 Glycome in Gastric Cancer - Functional and Clinical Impact
Orientador de Ângela Faria
 Project/Internship (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2023/04/20 - 2023/04/21 International Meeting of Young Researchers 2023 - Sour Turned Sweet: Glycans Bridging Technology and Precision Medicine COST Actions 18103 INNOGLY and 18132 GLYCONanoPROBES
2017/07/03 - 2017/07/04 IV BiotechHealth Annual Symposium - Spotting the differences: Biotechnology driving precision medicine Institute for Research and Innovation in Health (i3S), University of Porto

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2023/08/22 - 2023/09/12 Dutch Research Council (NWO) Round Open Competition Domain Science Package 22-6 - Evaluation of Scientific Project Applications.
Avaliador
 Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Países Baixos Nederlandse Organisatie voor Wetenschappelijk Onderzoek
2022/04 - 2022/04 Croatia-China Scientific and Technological Cooperation Call for Project Proposals for R&D Projects.
Avaliador
 Department of International Cooperation

Hrvatska zaklada za znanost

Membro de associação

Nome da associação Tipo de participação
2022/10/20 - Atual European Cooperation in Science and Technology (COST) Affiliated member
2017/03/14 - Atual European Association for Cancer Research Affiliated member
2017/03/14 - Atual Associação Portuguesa de Investigação em Cancro (ASPIC) Affiliated member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023/06/14 - 2023/06/16 15th Jenner Glycobiology and Medicine Symposium - Organizing Committee
Membro
 The Royal Society of Medicine, Reino Unido

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2024/12/01 - 2024/12/01 Call for a Research Technician within the FCT-funded project SweetKiller: Monosaccharide Analogues as Novel Therapeutic Agents to Block Glycan-Driven Cancer Cell Metastasis (PTDC/MED-QUI/2335/2021), alternate member of the jury. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/06/14 - 2023/06/16 15th Jenner Glycobiology and Medicine Symposium. Royal Society of Medicine and i3S, Porto, Portugal. Evaluation of poster presentations. The Royal Society of Medicine, Reino Unido

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/03/01 - 2023/03/01 Call for a Research Fellow (BI-M) within the FCT-funded project MGL4Life - Targeting Human Macrophage Galactose C-type Lectin Towards the Development of Innovative and Alternative Cancer Therapies (PTDC/QUI-OUT/2586/2020), member of the jury. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/03/01 - 2023/03/01 Call for a Research Fellow (BI-M) within the FCT-funded project EMERGENCE – ErbB2 Molecular Heterogeneity Drives Glycan-Mediated Trastuzumab Resistance (2022.04138.PTDC), President of the jury. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/02/23 - 2023/02/24 9th McBiology Symposium – Science: Everything, Everywhere All at Once. i3S, Porto, Portugal. Evaluation of oral communications. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/07/01 - 2022/07/01 Call for a Junior Researcher holding a PhD degree within the FCT-funded project SweetKiller: Monosaccharide Analogues as Novel Therapeutic Agents to Block Glycan-Driven Cancer Cell Metastasis (PTDC/MED-QUI/2335/2021), member of the jury. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/11/30 - 2021/11/30 4th PhDay at i3S – Break Borders, Build Opportunities. i3S, Porto, Portugal. Evaluation of oral communications and poster presentations. Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Tutoria

Tópico Nome do aluno
2024/09/10 - 2024/11/30 Scientific Supervision of Visiting PhD Student Secondment - Jhenifer Santos dos Reis Jhenifer Santos dos Reis
2023/02/01 - 2023/05/31 Scientific supervision of the PhD student Kristína Kianicková, from the Slovak Academy of Sciences, in the context of the National Scholarship Program from the Slovak Republic. Kristína Kianicková
2022/09/01 - 2022/10/15 Scientific supervision of the PhD student Kristína Kianicková, from the Slovak Academy of Sciences, in the context of the COST Action CA18103 Kristína Kianicková
2022/04/01 - 2022/04/30 Scientific supervision of the MSc student Catarina Costa in the curricular unit Laboratorial Rotation of the Master in Biomedical Research of the University of Coimbra. Catarina Costa
2021/10/01 - 2022/02/28 Scientific Mentoring - Integrated Master in Bioengineering (University of Porto), Project in Molecular Bioengineering André Oliveira; Filipa Ferreira; Francisco Ferreira; Inês Faria; José Maria Costa
2021/10/01 - 2022/02/28 Curricular Unit Project in Biomedical Engineering of the Integrated Master in Bioengineering (FEUP/ICBAS) Inês Faria; André Oliveira; Filipa Ferreira; Francisca Ferreira; José Maria Costa.
2020/01/14 - 2020/01/14 Invited speaker at Semana das Profissões of Colégio Nossa Senhora do Rosário, in the Health Sciences panel Several
2016/06/27 - 2016/07/01 Mentor of the Ciência Viva educational program, organized by the Agência Nacional para a Cultura Científica e Tecnológica Several
2015/03/21 - 2015/03/21 Invited speaker at the III AEICBAS Biomedical Congress Several
2015/03/12 - 2015/03/15 Ipatimup representative at Mostra de Ciência, Ensino e Educação da Universidade do Porto Several
Distinções

Prémio

2023 26th Annual Meeting of the Portuguese Society of Human Genetics (SPGH) – SPGH Annual Award for Best Scientific Paper
Sociedade Portuguesa de Genética Humana, Portugal
2022 Travel and Registration Grant awarded by the European Association for Cancer Research, at the EACR 2022 Congress - Innovative Cancer Science: Translatin Biology to Medicine
European Association For Cancer Research, Reino Unido
2021 Prémio Francisco Augusto da Fonseca Dias e Maria José Melenas da Fonseca para Jovens Investigadores
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2019 Travel and Registration Grant for the 25th International Symposium on Glycoconjugates
2019 Best Speed Talk Presentation at the 26th Porto Cancer Meeting - The Cancer Ecosystem: from Research to Pathology & Treatment
2019 Winner of the 1st edition of the i3S (Institute for Research and Innovation in Health) Fundraising Travel Grant
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 EACR Travel Fellowship
European Association For Cancer Research, Reino Unido
2018 Travel and Registration Grant for the practical course Genome Engineering: CRISPR / Cas organized by the European Molecular Biology Laboratory (EMBL)
Boehringer Ingelheim Auslandsbeteiligungs GmbH, Alemanha
2018 Travel and Registration Grant awarded by the European Association for Cancer Research, at the EACR25 – 25th Biennal Congress of the European Association for Cancer Research
European Association For Cancer Research, Reino Unido
2018 Best Poster Presentation and Travel Grant at the practical course “From Protein Structure to Biological Function through an Interactomics: An Integrated View
2018 Merit Scholarship for Exceptional Achievement as a student of the Faculty of Engineering of the University of Porto (2009/2010-2013/2014), attributed by the Directorate General of Higher Education and the Ministry of Education of the Portuguese government
Governo da República Portuguesa, Portugal
2016 Travel and Registration Grant awarded by the European Society for Medical Oncology, at the ESMO Symposium on Signalling Pathways in Cancer 2016
European Society for Medical Oncology, Suiça
2015 Oncology and Molecular Biology Poster Presentation First Prize for the work Phosphorylation of the Estrogen Receptor Alpha in Breast Cancer: The Hunt for the Elusive Kinase, at the 10th edition of the Young European Scientist (YES) Meeting

Outra distinção

2022 FEBS Letters Issue Cover Illustration
Federation of European Biochemical Societies, Reino Unido