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Mireia Castillo-Martin. Completed the Doctorat in La valoració de les alteracions genètiques i de l'immunofenotip millora la detecció i seguiment de les neoplàsies urotelials in 2006/10/25 by Universitat de Barcelona Departament de Biologia Cellular, DEA in Anatomia Patològica in 2003/05/01 by Universitat Autònoma de Barcelona, Postgraduate Certificate in Especialitat en Anatomia Patológica in 2002/05/01 by Atenció Sociosanitària Hospital Clínic and Bachelor in Medicina i Cirurgia in 1994/07/01 by Universitat de Barcelona. Facultat de Medicina. Is Team Leader in the Champalimaud Centre for the Unknown (CCU), Attending pathologist in Centro Clínico Champalimaud, Assistant Professor of Research in Icahn School of Medicine at Mount Sinai Lillian and Henry M Stratton-Hans Popper Department of Pathology and Laboratory Medicine and Director of the Champalimaud Foundation Biobank (CFB) in the CCU. Published 89 articles in journals. Has 5 section(s) of books. Has 1 patent(s) registered. Supervised 1 PhD thesis(es). Supervised 3 MSc dissertation(s). Has received 3 awards and/or honors. Participates and/or participated as Principal investigator in 2 project(s) and Researcher in 3 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Pathology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: bladder cancer; .
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Identificação

Identificação pessoal

Nome completo
Mireia Castillo-Martin

Nomes de citação

  • Castillo-Martin, Mireia
  • Castillo-Martin M
  • Castillo M

Identificadores de autor

Ciência ID
CF1A-4E80-8168
ORCID iD
0000-0001-8926-6013

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Patologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Catalão (Idioma materno)
Espanhol; Castelhano (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2006/10/25
Concluído
 La valoració de les alteracions genètiques i de l'immunofenotip millora la detecció i seguiment de les neoplàsies urotelials (Doctorat)
Universitat de Barcelona Departament de Biologia Cellular, Espanha
"Evaluation of the genetic and immunophenotypical alterations improves primary detection and follow-up of urothelial neoplasms. " (TESE/DISSERTAÇÃO)
 Excelente Cum Laude
2003/05/01
Concluído
 Anatomia Patològica (DEA)
Universitat Autònoma de Barcelona, Espanha
 n/a
2002/05/01
Concluído
 Especialitat en Anatomia Patológica (Postgraduate Certificate)
Atenció Sociosanitària Hospital Clínic, Espanha
"n/a" (TESE/DISSERTAÇÃO)
 n/a
1994/07/01
Concluído
 Llicenciatura en Medicina i Cirurgia (Bachelor)
Universitat de Barcelona. Facultat de Medicina, Espanha
"n/a" (TESE/DISSERTAÇÃO)
 n/a
Percurso profissional

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/06 - Atual Director of the Champalimaud Foundation Biobank (CFB) Centro Champalimaud, Portugal
2015/08/01 - Atual Team Leader Centro Champalimaud, Portugal
2015/08/01 - Atual Attending pathologist Centro Champalimaud, Portugal
2011/04/11 - Atual Assistant Professor of Research Icahn School of Medicine at Mount Sinai Lillian and Henry M Stratton-Hans Popper Department of Pathology and Laboratory Medicine, Estados Unidos
2011/04/11 - 2015/07/31 Co-Director of the Biorepository and Pathology CORE Icahn School of Medicine at Mount Sinai Lillian and Henry M Stratton-Hans Popper Department of Pathology and Laboratory Medicine, Estados Unidos
2009/11/01 - 2011/04/10 Associate Research Scientist Herbert Irving Comprehensive Cancer Center, Estados Unidos
2006/12/01 - 2009/10/31 Postdoctoral Fellow Herbert Irving Comprehensive Cancer Center, Estados Unidos
2004/12/01 - 2006/07/31 Attending pathologist Hospital Universitari de Bellvitge, Espanha
2003/07/01 - 2004/11/30 Attending pathologist Hospital Clínic de Barcelona, Espanha
2002/11/01 - 2003/06/30 Research Fellow Hospital Clínic de Barcelona, Espanha
2002/06/01 - 2002/07/31 Attending pathologist Hospital Clínic de Barcelona, Espanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2002/08/01 - 2002/10/31 Volunteering in the Hospital of Bathalapalli Fundación Vicente Ferrer, Índia
Projetos

Bolsa

Designação Financiadores
2023/07/01 - 2026/06/30 Innovative approaches for pancreatic cancer: Decoding and manipulating immune response to short sialylated O-glycans
2022. 04607.PTDC
Co-Investigador Responsável (Co-IR)
Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2012/08/01 - 2022/03/31 ROLES AND REGULATION OF P53
info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/5P01CA087497-04/US
Investigador
Center for Cancer Research
Em curso
2019/01/01 - 2021/12/31 Eradicating prostate cancer metastasis before clinical manifestation
HR17-00094
Investigador responsável
Fundação Champalimaud, Portugal
 Caixa d'Estalvis i Pensions de Barcelona
Em curso
2017/01/01 - 2019/12/31 Mecanismos epigenéticos de resistencia a la castración en cancer de próstata: oportunidades terapéuticas en combinación con antagonistas del receptor de andrógenos
Ref.: PI16/01070
Investigador
Concluído
2016/05/01 - 2017/04/30 Genomic analysis of primary muscle-invasive bladder cancers and correlation with clinical outcomes
xxx
Investigador
Vasculonox Inc
Concluído
2012/07/01 - 2014/06/30 Role of ¿Np63 isoform in progression from high grade non-muscle invasive to invasive bladder cancer.
xxx
Investigador responsável
SASS Foundation
Concluído
Produções

Publicações

Artigo em revista
  1. Bilreiro, Carlos; Fernandes, Francisca F.; Simões, Rui V.; Henriques, Rafael; Chavarrías, Cristina; Ianus, Andrada; Castillo-Martin, Mireia; et al. "Pancreatic Intraepithelial Neoplasia Revealed by Diffusion-Tensor MRI". Investigative Radiology (2024): https://doi.org/10.1097/rli.0000000000001142.
    10.1097/rli.0000000000001142
  2. Herrando, Alberto Ignacio; Fernandez, Laura M.; Azevedo, José; Vieira, Pedro; Domingos, Hugo; Galzerano, Antonio; Shcheslavskiy, Vladislav; et al. "Detection and characterization of colorectal cancer by autofluorescence lifetime imaging on surgical specimens". Scientific Reports 14 1 (2024): https://doi.org/10.1038/s41598-024-74224-8.
    10.1038/s41598-024-74224-8
  3. Costa, Bruna; Estrada, Marta F.; Gomes, António; Fernandez, Laura M.; Azevedo, José M.; Póvoa, Vanda; Fontes, Márcia; et al. "Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients with colorectal cancer". Nature Communications 15 1 (2024): https://doi.org/10.1038/s41467-024-49051-0.
    10.1038/s41467-024-49051-0
  4. Herrando, Alberto I.; Castillo-Martin, Mireia; Galzerano, Antonio; Fernández, Laura; Vieira, Pedro; Azevedo, José; Parvaiz, Amjad; et al. "Dual excitation spectral autofluorescence lifetime and reflectance imaging for fast macroscopic characterization of tissues". Biomedical Optics Express 15 6 (2024): 3507. https://doi.org/10.1364/boe.505220.
    10.1364/boe.505220
  5. Andreia Maia; Mubin Tarannum; Joana R. Lérias; Sara Piccinelli; Luis Miguel Borrego; Markus Maeurer; Rizwan Romee; Mireia Castillo-Martin. "Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy". Cells (2024): https://doi.org/10.3390/cells13050451.
    10.3390/cells13050451
  6. El Sissy, Carine; Kirilovsky, Amos; Lagorce Pagès, Christine; Marliot, Florence; Custers, Petra A.; Dizdarevic, Edina; Sroussi, Marine; et al. "International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy". Journal of Clinical Oncology 42 1 (2024): 70-80. http://dx.doi.org/10.1200/jco.23.00586.
    10.1200/jco.23.00586
  7. Cordeiro, Rodrigo; Morgado, Margarida; Oliveira, Vera; Bispo, Miguel; Castillo-Martin, Mireia; Matos, Celso. "Gastric schwannoma: Two case reports and review of the literature". Radiology Case Reports 18 12 (2023): 4465-4473. http://dx.doi.org/10.1016/j.radcr.2023.09.048.
    10.1016/j.radcr.2023.09.048
  8. Piras, Roberta; Ko, Emily Y.; Barrett, Connor; De Simone, Marco; Lin, Xianzhi; Broz, Marina T.; Tessaro, Fernando H. G.; et al. "circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-34872-8.
    10.1038/s41467-022-34872-8
  9. Treaba, Diana O.; Bonal, Dennis M.; Chorzalska, Anna; Castillo-Martin, Mireia; Oakes, Alissa; Pardo, Makayla; Petersen, Max; et al. "Transcriptomics of acute myeloid leukaemia core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles". British Journal of Haematology 200 6 (2022): 740-754. http://dx.doi.org/10.1111/bjh.18513.
    10.1111/bjh.18513
  10. Costa, Bruna; Fernandez, Laura M.; Parés, Oriol; Rio-Tinto, Ricardo; Santiago, Inês; Castillo-Martin, Mireia; Parvaiz, Amjad; Fior, Rita. "Zebrafish Avatars of rectal cancer patients validate the radiosensitive effect of metformin". Frontiers in Oncology 12 (2022): http://dx.doi.org/10.3389/fonc.2022.862889.
    10.3389/fonc.2022.862889
  11. Abdulghani, Saba; Afonso, Ângela; Castillo, Mireia; Martín-Fernández, Javier; Franco, Inês; Parreira, Bruna; Couto, Ana; et al. "The Role of Biobanks in the Fight against COVID-19 Pandemic: The Portuguese Response". Acta Médica Portuguesa 35 6 (2022): 411-415. http://dx.doi.org/10.20344/amp.17856.
    10.20344/amp.17856
  12. Zabala-Letona, Amaia; Arruabarrena-Aristorena, Amaia; Fernandez-Ruiz, Sonia; Viera, Cristina; Carlevaris, Onintza; Ercilla, Amaia; Mendizabal, Isabel; et al. "PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer". Oncogenesis 11 1 (2022): http://dx.doi.org/10.1038/s41389-022-00382-x.
    10.1038/s41389-022-00382-x
  13. Kirilovsky, Amos; Sissy, Carine El; Zeitoun, Guy; Marliot, Florence; Haicheur, Nacilla; Lagorce-Pagès, Christine; Taieb, Julien; et al. "The “Immunoscore” in rectal cancer: could we search quality beyond quantity of life?". Oncotarget 13 1 (2022): 18-31. http://dx.doi.org/10.18632/oncotarget.28100.
    10.18632/oncotarget.28100
  14. Kanagasabai, Thanigaivelan; Li, Guoliang; Shen, Tian Huai; Gladoun, Nataliya; Castillo-Martin, Mireia; Celada, Sherly I.; Xie, Yingqiu; et al. "MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway". Cancer Letters 525 (2022): 46-54. http://dx.doi.org/10.1016/j.canlet.2021.09.041.
    10.1016/j.canlet.2021.09.041
  15. Fernandez, Laura M.; Figueiredo, Nuno; Habr-Gama, Angelita; São Julião, Guilherme P.; Vieira, Pedro; Vailati, Bruna B.; Nasir, Irfan; et al. "cT2N0 Distal Rectal Cancer: Do Not Believe in Fairy Tales". Diseases of the Colon & Rectum 65 1 (2021): e22-e22. http://dx.doi.org/10.1097/dcr.0000000000002307.
    10.1097/dcr.0000000000002307
  16. Flor-de-Lima, Beatriz; S· Freitas, Patrícia; Couto, Nuno; Castillo-Martin, Mireia; Santiago, Inês. "Pancreatic intraductal papillary mucinous neoplasm associated colloid carcinoma". Radiology Case Reports 16 10 (2021): 2989-2992. http://dx.doi.org/10.1016/j.radcr.2021.07.021.
    10.1016/j.radcr.2021.07.021
  17. Tavares Barroso, Mariana; Costa, Bruna; Rebelo de Almeida, Cátia; Castillo Martin, Mireia; Couto, Nuno; Carvalho, Tânia; Fior, Rita. "Establishment of Pancreatobiliary Cancer Zebrafish Avatars for Chemotherapy Screening". Cells 10 8 (2021): 2077. http://dx.doi.org/10.3390/cells10082077.
    Publicado • 10.3390/cells10082077
  18. Sofia C. Vaz; Mireia Castillo-Martin; Ângelo F. Silva; Joana C. Castanheira; Carla Oliveira; Durval C. Costa. "PSMA expression in thyroid nodule". Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) (2021): https://doi.org/10.1016/j.remnie.2020.04.010.
    10.1016/j.remnie.2020.04.010
  19. de Sousa, Eric; Lérias, Joana R.; Beltran, Antonio; Paraschoudi, Georgia; Condeço, Carolina; Kamiki, Jéssica; António, Patrícia Alexandra; et al. "Targeting Neoepitopes to Treat Solid Malignancies: Immunosurgery". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.592031.
    10.3389/fimmu.2021.592031
  20. Fernandez, Laura M.; Figueiredo, Nuno L.; Habr-Gama, Angelita; São Julião, Guilherme P.; Vieira, Pedro; Vailati, • Bruna B.; Nasir, Irfan; et al. "Salvage Surgery With Organ Preservation for Patients With Local Regrowth After Watch and Wait: Is It Still Possible?". Diseases of the Colon & Rectum 63 8 (2020): 1053-1062. http://dx.doi.org/10.1097/dcr.0000000000001707.
    10.1097/dcr.0000000000001707
  21. Castillo-Martin, Mireia; Sofia Carrilho Vaz; Ângelo Silva; Carla Oliveira; Rita Marques; António Galzerano; Mireia Castillo-Martin. "Impact of PSMA PET/CT in prostate cancer patient’s clinical management – a pictorial essay of interesting cases with histologic confirmation". Clinical and Translational Imaging (2020): https://doi.org/10.1007/s40336-020-00372-2.
    Em revisão • 10.1007/s40336-020-00372-2
  22. Castillo-Martin, Mireia. "Antagonistic roles of deltaNp63 and AGR2 in progression of Non-Muscle Invasive Bladder Cancer and their potential therapeutic implications". Clinical Cancer Research (2020):
    Submetido
  23. Lérias, Joana R.; Paraschoudi, Georgia; de Sousa, Eric; Martins, João; Condeço, Carolina; Figueiredo, Nuno; Carvalho, Carlos; et al. "Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies". Frontiers in Cell and Developmental Biology 7 (2020): http://dx.doi.org/10.3389/fcell.2019.00362.
    Publicado • 10.3389/fcell.2019.00362
  24. Lérias, Joana R.; de Sousa, Eric; Paraschoudi, Georgia; Martins, João; Condeço, Carolina; Figueiredo, Nuno; Carvalho, Carlos; et al. "Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities". Frontiers in Microbiology 10 (2020): http://dx.doi.org/10.3389/fmicb.2019.02924.
    Publicado • 10.3389/fmicb.2019.02924
  25. Sousa Félix, Catarina; Chaves Marques, Susana; Bispo, Miguel; Castillo, Mireia; Bana e Costa, Tiago; Chagas, Cristina. "A Pancreatic Cyst Leading to Obstructive Jaundice". GE - Portuguese Journal of Gastroenterology 27 6 (2020): 446-448. http://dx.doi.org/10.1159/000507203.
    10.1159/000507203
  26. Castillo-Martin, Mireia; Gladoun, Nataliya; Han, Dan; Firpo-Betancourt, Adolfo; Silva, Jose M.; Cordon-Cardo, Carlos; Mireia Castillo-Martin; et al. "Transformed bone marrow cells generate neoplasms of distinct histogenesis. a murine model of cancer transplantation". Stem Cell Research 41 (2019): 101637-101637. http://dx.doi.org/10.1016/j.scr.2019.101637.
    Publicado • 10.1016/j.scr.2019.101637
  27. Nasir, Irfan; Fernandez, Laura; Vieira, Pedro; Parés, Oriol; Santiago, Inês; Castillo-Martin, Mireia; Domingos, Hugo; et al. "Salvage surgery for local regrowths in Watch & Wait - Are we harming our patients by deferring the surgery?". European Journal of Surgical Oncology 45 9 (2019): 1559-1566. http://dx.doi.org/10.1016/j.ejso.2019.04.006.
    10.1016/j.ejso.2019.04.006
  28. Chuang, Ling-shiang; Morrison, Joshua; Hsu, Nai-yun; Labrias, Philippe Ronel; Nayar, Shikha; Chen, Ernie; Villaverde, Nicole; et al. "Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease". Disease Models & Mechanisms 12 8 (2019): dmm037432. http://dx.doi.org/10.1242/dmm.037432.
    Publicado • 10.1242/dmm.037432
  29. Guarnerio, Jlenia; Zhang, Yang; Cheloni, Giulia; Panella, Riccardo; Mae Katon, Jesse; Simpson, Mark; Matsumoto, Akinobu; et al. "Intragenic antagonistic roles of protein and circRNA in tumorigenesis". Cell Research 29 8 (2019): 628-640. http://dx.doi.org/10.1038/s41422-019-0192-1.
    Publicado • 10.1038/s41422-019-0192-1
  30. Bispo, Miguel; Rio-Tinto, Ricardo; Fidalgo, Paulo; Castillo-Martin, Mireia; Devière, Jacques. "Late Colon Involvement by Lobular Carcinoma of the Breast: A Diagnosis to Keep in Mind!". GE - Portuguese Journal of Gastroenterology 27 1 (2019): 47-49. http://dx.doi.org/10.1159/000497390.
    Publicado • 10.1159/000497390
  31. Ming Chen; Jiangwen Zhang; Alice H. Berger; Moussa S. Diolombi; Christopher Ng; Jacqueline Fung; Roderick T. Bronson; et al. "Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis". Journal of Clinical Investigation (2018): https://doi.org/10.1172/JCI99699.
    10.1172/JCI99699
  32. Wang, Li; Saci, Abdel; Szabo, Peter M.; Chasalow, Scott D.; Castillo-Martin, Mireia; Domingo-Domenech, Josep; Siefker-Radtke, Arlene; et al. "EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-05992-x.
    10.1038/s41467-018-05992-x
  33. Lee, Eunjee; Collazo-Lorduy, Ana; Castillo-Martin, Mireia; Gong, Yixuan; Wang, Li; Oh, William K.; Galsky, Matthew D.; Cordon-Cardo, Carlos; Zhu, Jun. "Identification of microR-106b as a prognostic biomarker of p53-like bladder cancers by ActMiR". Oncogene 37 44 (2018): 5858-5872. http://dx.doi.org/10.1038/s41388-018-0367-0.
    10.1038/s41388-018-0367-0
  34. Pozo, Eduardo; Castellano, Jose M.; Kanwar, Anubhav; Deochand, Rajiv; Castillo-Martin, Mireia; Pazos-López, Pablo; González-Lengua, Carlos; et al. "Myocardial Amyloid Quantification with Look-Locker Magnetic Resonance Sequence in Cardiac Amyloidosis. Diagnostic Accuracy in Clinical Practice and Histological Validation". Journal of Cardiac Failure 24 2 (2018): 78-86. http://dx.doi.org/10.1016/j.cardfail.2017.08.445.
    Publicado • 10.1016/j.cardfail.2017.08.445
  35. Martín-Martín, Natalia; Zabala-Letona, Amaia; Fernández-Ruiz, Sonia; Arreal, Leire; Camacho, Laura; Castillo-Martin, Mireia; Cortazar, Ana R.; et al. "PPARd Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth". Cancer Research 78 2 (2018): 399-409. http://dx.doi.org/10.1158/0008-5472.can-17-0908.
    10.1158/0008-5472.can-17-0908
  36. Chen, Ming; Zhang, Jiangwen; Sampieri, Katia; Clohessy, John G.; Mendez, Lourdes; Gonzalez-Billalabeitia, Enrique; Liu, Xue-Song; et al. "An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer". Nature Genetics 50 2 (2018): 206-218. http://dx.doi.org/10.1038/s41588-017-0027-2.
    10.1038/s41588-017-0027-2
  37. Castillo-Martin, Mireia. "Intracholecystic papillary-tubular neoplasm in a patient with choledochal cyst and anomalous pancreaticobiliary junction: case report". BJR Case Rep 4 20180079 (2018):
    Publicado
  38. Zabala-Letona, Amaia; Arruabarrena-Aristorena, Amaia; Martín-Martín, Natalia; Fernandez-Ruiz, Sonia; Sutherland, James D.; Clasquin, Michelle; Tomas-Cortazar, Julen; et al. "mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer". Nature 547 7661 (2017): 109-113. http://dx.doi.org/10.1038/nature22964.
    10.1038/nature22964
  39. Agrawal, Praveen; Fontanals-Cirera, Barbara; Sokolova, Elena; Jacob, Samson; Vaiana, Christopher A.; Argibay, Diana; Davalos, Veronica; et al. "A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis". Cancer Cell 31 6 (2017): 804-819.e7. http://dx.doi.org/10.1016/j.ccell.2017.05.007.
    10.1016/j.ccell.2017.05.007
  40. Kuchay, Shafi; Giorgi, Carlotta; Simoneschi, Daniele; Pagan, Julia; Missiroli, Sonia; Saraf, Anita; Florens, Laurence; et al. "PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth". Nature 546 7659 (2017): 554-558. http://dx.doi.org/10.1038/nature22965.
    Publicado • 10.1038/nature22965
  41. Chen, Muhan; Nowak, Dawid G.; Narula, Navneet; Robinson, Brian; Watrud, Kaitlin; Ambrico, Alexandra; Herzka, Tali M.; et al. "The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein". Journal of Cell Biology 216 3 (2017): 641-656. http://dx.doi.org/10.1083/jcb.201604025.
    Publicado • 10.1083/jcb.201604025
  42. Shukla-Dave, Amita; Castillo-Martin, Mireia; Chen, Ming; Lobo, Jose; Gladoun, Nataliya; Collazo-Lorduy, Ana; Khan, Faisal M.; et al. "Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling". The American Journal of Pathology 186 12 (2016): 3131-3145. http://dx.doi.org/10.1016/j.ajpath.2016.08.021.
    10.1016/j.ajpath.2016.08.021
  43. Collazo-Lorduy, Ana; Castillo-Martin, Mireia; Wang, Li; Patel, Vaibhav; Iyer, Gopa; Jordan, Emmet; Al-Ahmadie, Hikmat; et al. "Urachal Carcinoma Shares Genomic Alterations with Colorectal Carcinoma and May Respond to Epidermal Growth Factor Inhibition". European Urology 70 5 (2016): 771-775. http://dx.doi.org/10.1016/j.eururo.2016.04.037.
    Publicado • 10.1016/j.eururo.2016.04.037
  44. Torrano, Veronica; Valcarcel-Jimenez, Lorea; Cortazar, Ana Rosa; Liu, Xiaojing; Urosevic, Jelena; Castillo-Martin, Mireia; Fernández-Ruiz, Sonia; et al. "The metabolic co-regulator PGC1a suppresses prostate cancer metastasis". Nature Cell Biology 18 6 (2016): 645-656. http://dx.doi.org/10.1038/ncb3357.
    Publicado • 10.1038/ncb3357
  45. Mireia Castillo-Martin; Ana Collazo Lorduy; Nataliya Gladoun; Grace Hyun; Carlos Cordon-Cardo; Castillo-Martin, Mireia; Collazo Lorduy, Ana; et al. "H-RAS mutation is a key molecular feature of pediatric urothelial bladder cancer. A detailed report of three cases". Journal of Pediatric Urology 12 2 (2016): 91.e1-91.e7. http://dx.doi.org/10.1016/j.jpurol.2015.08.020.
    Publicado • 10.1016/j.jpurol.2015.08.020
  46. Herranz, Daniel; Ambesi-Impiombato, Alberto; Sudderth, Jessica; Sánchez-Martín, Marta; Belver, Laura; Tosello, Valeria; Xu, Luyao; et al. "Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia". Nature Medicine 21 10 (2015): 1182-1189. http://dx.doi.org/10.1038/nm.3955.
    10.1038/nm.3955
  47. Rodriguez-Barrueco, Ruth; Yu, Jiyang; Saucedo-Cuevas, Laura P.; Olivan, Mireia; Llobet-Navas, David; Putcha, Preeti; Castro, Veronica; et al. "Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR-/HER2+ breast cancers". Genes & Development 29 15 (2015): 1631-1648. http://dx.doi.org/10.1101/gad.262642.115.
    10.1101/gad.262642.115
  48. Nowak, Dawid G.; Cho, Hyejin; Herzka, Tali; Watrud, Kaitlin; DeMarco, Daniel V.; Wang, Victoria M.Y.; Senturk, Serif; et al. "MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2". Cancer Discovery 5 6 (2015): 636-651. http://dx.doi.org/10.1158/2159-8290.cd-14-1113.
    10.1158/2159-8290.cd-14-1113
  49. Barber, Alison G.; Castillo-Martin, Mireia; Bonal, Dennis M.; Jia, Angela J.; Rybicki, Benjamin A.; Christiano, Angela M.; Cordon-Cardo, Carlos. "PI3K/AKT pathway regulates E-cadherin and Desmoglein 2 in aggressive prostate cancer". Cancer Medicine 4 8 (2015): 1258-1271. http://dx.doi.org/10.1002/cam4.463.
    Publicado • 10.1002/cam4.463
  50. Wu, Ying-Yu; Georg, Ina; Díaz-Barreiro, Alejandro; Varela, Nieves; Lauwerys, Bernard; Kumar, Ramesh; Bagavant, Harini; et al. "Concordance of Increased B1 Cell Subset and Lupus Phenotypes in Mice and Humans Is Dependent on BLK Expression Levels". The Journal of Immunology 194 12 (2015): 5692-5702. http://dx.doi.org/10.4049/jimmunol.1402736.
    Publicado • 10.4049/jimmunol.1402736
  51. Lunardi, Andrea; Varmeh, Shohreh; Chen, Ming; Taulli, Riccardo; Guarnerio, Jlenia; Ala, Ugo; Seitzer, Nina; et al. "Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis". Cancer Discovery 5 5 (2015): 550-563. http://dx.doi.org/10.1158/2159-8290.cd-13-1050.
    10.1158/2159-8290.cd-13-1050
  52. Ugalde-Olano, Aitziber; Egia, Ainara; Fernández-Ruiz, Sonia; Loizaga-Iriarte, Ana; Zuñiga-García, Patricia; Garcia, Stephane; Royo, Félix; et al. "Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN". Methods 77-78 (2015): 25-30. http://dx.doi.org/10.1016/j.ymeth.2015.02.005.
    Publicado • 10.1016/j.ymeth.2015.02.005
  53. Guarnerio, Jlenia; Riccardi, Luisa; Taulli, Riccardo; Maeda, Takahiro; Wang, Guocan; Hobbs, Robin M.; Song, Min Sup; et al. "A Genetic Platform to Model Sarcomagenesis from Primary Adult Mesenchymal Stem Cells". Cancer Discovery 5 4 (2015): 396-409. http://dx.doi.org/10.1158/2159-8290.cd-14-1022.
    10.1158/2159-8290.cd-14-1022
  54. Gaya, Josep M.; López-Martínez, Juan M.; Karni-Schmidt, Orit; Bonal, Dennis M.; Algaba, Ferran; Palou, Joan; Villavicencio, Humberto; et al. "¿Np63 Expression is a Protective Factor of Progression in Clinical High Grade T1 Bladder Cancer". Journal of Urology 193 4 (2015): 1144-1150. http://dx.doi.org/10.1016/j.juro.2014.10.098.
    10.1016/j.juro.2014.10.098
  55. Puzio-Kuter, A M; Laddha, S V; Castillo-Martin, M; Sun, Y; Cordon-Cardo, C; Chan, C S; Levine, A J. "Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma". Cell Death & Differentiation 22 11 (2015): 1785-1791. http://dx.doi.org/10.1038/cdd.2015.27.
    10.1038/cdd.2015.27
  56. Danielson, Laura S.; Reavie, Linsey; Coussens, Marc; Davalos, Veronica; Castillo-Martin, Mireia; Guijarro, Maria V.; Coffre, Maryaline; et al. "Limited miR-17-92 overexpression drives hematologic malignancies". Leukemia Research 39 3 (2015): 335-341. http://dx.doi.org/10.1016/j.leukres.2014.12.002.
    Publicado • 10.1016/j.leukres.2014.12.002
  57. Epping, M T; Lunardi, A; Nachmani, D; Castillo-Martin, M; Thin, T H; Cordon-Cardo, C; Pandolfi, P P. "TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFß signaling activation". Cell Death & Differentiation 22 8 (2015): 1353-1362. http://dx.doi.org/10.1038/cdd.2014.226.
    Publicado • 10.1038/cdd.2014.226
  58. Sia, Daniela; Losic, Bojan; Moeini, Agrin; Cabellos, Laia; Hao, Ke; Revill, Kate; Bonal, Dennis; et al. "Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma". Nature Communications 6 1 (2015): http://dx.doi.org/10.1038/ncomms7087.
    Publicado • 10.1038/ncomms7087
  59. Di Sante, Gabriele; Pestell, Timothy G.; Casimiro, Mathew C.; Bisetto, Sara; Powell, Michael J.; Lisanti, Michael P.; Cordon-Cardo, Carlos; et al. "Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria". The American Journal of Pathology 185 1 (2015): 266-279. http://dx.doi.org/10.1016/j.ajpath.2014.09.014.
    10.1016/j.ajpath.2014.09.014
  60. Llobet-Navas, D.; Rodriguez-Barrueco, R.; de la Iglesia-Vicente, J.; Olivan, M.; Castro, V.; Saucedo-Cuevas, L.; Marshall, N.; et al. "The MicroRNA 424/503 Cluster Reduces CDC25A Expression during Cell Cycle Arrest Imposed by Transforming Growth Factor   in Mammary Epithelial Cells". Molecular and Cellular Biology 34 23 (2014): 4216-4231. http://dx.doi.org/10.1128/mcb.00611-14.
    Publicado • 10.1128/mcb.00611-14
  61. Herranz, Daniel; Ambesi-Impiombato, Alberto; Palomero, Teresa; Schnell, Stephanie A; Belver, Laura; Wendorff, Agnieszka A; Xu, Luyao; et al. "A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia". Nature Medicine 20 10 (2014): 1130-1137. http://dx.doi.org/10.1038/nm.3665.
    10.1038/nm.3665
  62. Barber, Alison G.; Castillo-Martin, Mireia; Bonal, Dennis M.; Rybicki, Benjamin A.; Christiano, Angela M.; Cordon-Cardo, Carlos. "Characterization of Desmoglein Expression in the Normal Prostatic Gland. Desmoglein 2 Is an Independent Prognostic Factor for Aggressive Prostate Cancer". PLoS ONE 9 6 (2014): e98786. http://dx.doi.org/10.1371/journal.pone.0098786.
    10.1371/journal.pone.0098786
  63. Harcharik, Sara; Bernardo, Sebastian; Moskalenko, Marina; Pan, Michael; Sivendran, Meera; Bell, Heather; Hall, Lawrence D.; et al. "Defining the role of CD2 in disease progression and overall survival among patients with completely resected stage-II to -III cutaneous melanoma". Journal of the American Academy of Dermatology 70 6 (2014): 1036-1044.e3. http://dx.doi.org/10.1016/j.jaad.2014.01.914.
    Publicado • 10.1016/j.jaad.2014.01.914
  64. Aydin, Iraz T.; Melamed, Rachel D.; Adams, Sarah J.; Castillo-Martin, Mireia; Demir, Ahu; Bryk, Diana; Brunner, Georg; et al. "FBXW7 Mutations in Melanoma and a New Therapeutic Paradigm". JNCI: Journal of the National Cancer Institute 106 6 (2014): http://dx.doi.org/10.1093/jnci/dju107.
    Publicado • 10.1093/jnci/dju107
  65. Jia, A Y; Castillo-Martin, M; Bonal, D M; Sánchez-Carbayo, M; Silva, J M; Cordon-Cardo, C. "MicroRNA-126 inhibits invasion in bladder cancer via regulation of ADAM9". British Journal of Cancer 110 12 (2014): 2945-2954. http://dx.doi.org/10.1038/bjc.2014.245.
    Publicado • 10.1038/bjc.2014.245
  66. Aytes, Alvaro; Mitrofanova, Antonina; Lefebvre, Celine; Alvarez, Mariano J.; Castillo-Martin, Mireia; Zheng, Tian; Eastham, James A.; et al. "Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy". Cancer Cell 25 5 (2014): 638-651. http://dx.doi.org/10.1016/j.ccr.2014.03.017.
    10.1016/j.ccr.2014.03.017
  67. Llobet-Navas, David; Rodríguez-Barrueco, Ruth; Castro, Verónica; Ugalde, Alejandro P.; Sumazin, Pavel; Jacob-Sendler, Damian; Demircan, Berna; et al. "The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland". Genes & Development 28 7 (2014): 765-782. http://dx.doi.org/10.1101/gad.237404.114.
    10.1101/gad.237404.114
  68. Cho, H.; Herzka, T.; Zheng, W.; Qi, J.; Wilkinson, J. E.; Bradner, J. E.; Robinson, B. D.; et al. "RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of Pten-Mutant Metastasis". Cancer Discovery 4 3 (2014): 318-333. http://dx.doi.org/10.1158/2159-8290.cd-13-0346.
    Publicado • 10.1158/2159-8290.cd-13-0346
  69. Piovan, Erich; Yu, Jiyang; Tosello, Valeria; Herranz, Daniel; Ambesi-Impiombato, Alberto; Da Silva, Ana Carolina; Sanchez-Martin, Marta; et al. "Direct Reversal of Glucocorticoid Resistance by AKT Inhibition in Acute Lymphoblastic Leukemia". Cancer Cell 24 6 (2013): 766-776. http://dx.doi.org/10.1016/j.ccr.2013.10.022.
    10.1016/j.ccr.2013.10.022
  70. Irshad, S.; Bansal, M.; Castillo-Martin, M.; Zheng, T.; Aytes, A.; Wenske, S.; Le Magnen, C.; et al. "A Molecular Signature Predictive of Indolent Prostate Cancer". Science Translational Medicine 5 202 (2013): 202ra122-202ra122. http://dx.doi.org/10.1126/scitranslmed.3006408.
    Publicado • 10.1126/scitranslmed.3006408
  71. Haupt, Sue; Mitchell, Catherine; Corneille, Vincent; Shortt, Jake; Fox, Stephen; Pandolfi, Pier Paolo; Castillo-Martin, Mireia; et al. "Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner". Cell Cycle 12 11 (2013): 1722-1731. http://dx.doi.org/10.4161/cc.24805.
    Publicado • 10.4161/cc.24805
  72. Jia, Angela Y.; Castillo-Martin, Mireia; Domingo-Domenech, Josep; Bonal, Dennis M.; Sánchez-Carbayo, Marta; Silva, Jose M.; Cordon-Cardo, Carlos. "A Common MicroRNA Signature Consisting of miR-133a, miR-139-3p, and miR-142-3p Clusters Bladder Carcinoma in Situ with Normal Umbrella Cells". The American Journal of Pathology 182 4 (2013): 1171-1179. http://dx.doi.org/10.1016/j.ajpath.2013.01.006.
    10.1016/j.ajpath.2013.01.006
  73. Domingo-Domenech, Josep; Vidal, Samuel J.; Rodriguez-Bravo, Veronica; Castillo-Martin, Mireia; Quinn, S. Aidan; Rodriguez-Barrueco, Ruth; Bonal, Dennis M.; et al. "Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells". Cancer Cell 22 3 (2012): 373-388. http://dx.doi.org/10.1016/j.ccr.2012.07.016.
    10.1016/j.ccr.2012.07.016
  74. Yang, Y; Wu, J; Demir, A; Castillo-Martin, M; Melamed, R D; Zhang, G; Fukunaga-Kanabis, M; et al. "GAB2 induces tumor angiogenesis in NRAS-driven melanoma". Oncogene 32 31 (2012): 3627-3637. http://dx.doi.org/10.1038/onc.2012.367.
    Publicado • 10.1038/onc.2012.367
  75. Samon, J. B.; Castillo-Martin, M.; Hadler, M.; Ambesi-Impiobato, A.; Paietta, E.; Racevskis, J.; Wiernik, P. H.; et al. "Preclinical Analysis of the  -Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia". Molecular Cancer Therapeutics 11 7 (2012): 1565-1575. http://dx.doi.org/10.1158/1535-7163.mct-11-0938.
    Publicado • 10.1158/1535-7163.mct-11-0938
  76. Shen, Tian Huai; Gladoun, Nataliya; Castillo-Martin, Mireia; Bonal, Dennis; Domingo-Domenech, Josep; Charytonowicz, Daniel; Cordon-Cardo, Carlos. "A BAC-Based Transgenic Mouse Specifically Expresses an Inducible Cre in the Urothelium". PLoS ONE 7 4 (2012): e35243. http://dx.doi.org/10.1371/journal.pone.0035243.
    Publicado • 10.1371/journal.pone.0035243
  77. Subramaniam, Prem S.; Whye, Dosh W.; Efimenko, Evgeni; Chen, Jianchung; Tosello, Valeria; De Keersmaecker, Kim; Kashishian, Adam; et al. "Targeting Nonclassical Oncogenes for Therapy in T-ALL". Cancer Cell 21 4 (2012): 459-472. http://dx.doi.org/10.1016/j.ccr.2012.02.029.
    10.1016/j.ccr.2012.02.029
  78. Charytonowicz, Elizabeth; Matushansky, Igor; Domingo-Doménech, Josep; Castillo-Martín, Mireia; Ladanyi, Marc; Cordon-Cardo, Carlos; Ziman, Mel. "PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation". Clinical and Translational Oncology 14 3 (2012): 197-206. http://dx.doi.org/10.1007/s12094-012-0784-4.
    10.1007/s12094-012-0784-4
  79. Wosnitzer, Matthew S.; Domingo-Domenech, Josep; Castillo-Martin, Mireia; Ritch, Chad; Mansukhani, Mahesh; Petrylack, Daniel P.; Benson, Mitchell C.; McKiernan, James M.; Cordon-Cardo, Carlos. "Predictive Value of Microtubule Associated Proteins Tau and Stathmin in Patients With Nonmuscle Invasive Bladder Cancer Receiving Adjuvant Intravesical Taxane Therapy". Journal of Urology 186 5 (2011): 2094-2100. http://dx.doi.org/10.1016/j.juro.2011.06.051.
    10.1016/j.juro.2011.06.051
  80. Chen, Muhan; Pratt, Christopher P.; Zeeman, Martha E.; Schultz, Nikolaus; Taylor, Barry S.; O'Neill, Audrey; Castillo-Martin, Mireia; et al. "Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression". Cancer Cell 20 2 (2011): 173-186. http://dx.doi.org/10.1016/j.ccr.2011.07.013.
    Publicado • 10.1016/j.ccr.2011.07.013
  81. Karni-Schmidt, Orit; Castillo-Martin, Mireia; HuaiShen, Tian; Gladoun, Nataliya; Domingo-Domenech, Josep; Sanchez-Carbayo, Marta; Li, Yingchun; et al. "Distinct Expression Profiles of p63 Variants during Urothelial Development and Bladder Cancer Progression". The American Journal of Pathology 178 3 (2011): 1350-1360. http://dx.doi.org/10.1016/j.ajpath.2010.11.061.
    Publicado • 10.1016/j.ajpath.2010.11.061
  82. Charytonowicz, Elizabeth; Matushansky, Igor; Castillo-Martin, Mireia; Hricik, Todd; Cordon-Cardo, Carlos; Ziman, Mel. "Alternate PAX3 and PAX7 C-terminal isoforms in myogenic differentiation and sarcomagenesis". Clinical and Translational Oncology 13 3 (2011): 194-203. http://dx.doi.org/10.1007/s12094-011-0640-y.
    Publicado • 10.1007/s12094-011-0640-y
  83. Reis, Leonardo Oliveira; Sopena, Josep Maria Gaya; Fávaro, Wagner José; Martin, Mireia Castilho; Simão, Antônio Felipe Leite; Reis, Rodolfo Borges dos; Andrade, Murilo Ferreira de; Domenech, Josep Domingo; Cardo, Carlos Cordon. "Anatomical features of the urethra and urinary bladder catheterization in female mice and rats. An essential translational tool". Acta Cirurgica Brasileira 26 suppl 2 (2011): 106-110. http://dx.doi.org/10.1590/s0102-86502011000800019.
    Publicado • 10.1590/s0102-86502011000800019
  84. De Keersmaecker, Kim; Real, Pedro J; Gatta, Giusy Della; Palomero, Teresa; Sulis, Maria Luisa; Tosello, Valeria; Van Vlierberghe, Pieter; et al. "The TLX1 oncogene drives aneuploidy in T cell transformation". Nature Medicine 16 11 (2010): 1321-1327. http://dx.doi.org/10.1038/nm.2246.
    10.1038/nm.2246
  85. Castillo-Martin, Mireia; Domingo-Domenech, Josep; Karni-Schmidt, Orit; Matos, Tulio; Cordon-Cardo, Carlos. "Molecular pathways of urothelial development and bladder tumorigenesis". Urologic Oncology: Seminars and Original Investigations 28 4 (2010): 401-408. http://dx.doi.org/10.1016/j.urolonc.2009.04.019.
    Publicado • 10.1016/j.urolonc.2009.04.019
  86. Van Vlierberghe, Pieter; Palomero, Teresa; Khiabanian, Hossein; Van der Meulen, Joni; Castillo, Mireia; Van Roy, Nadine; De Moerloose, Barbara; et al. "PHF6 mutations in T-cell acute lymphoblastic leukemia". Nature Genetics 42 4 (2010): 338-342. http://dx.doi.org/10.1038/ng.542.
    Publicado • 10.1038/ng.542
  87. MILLS, Joslyn; MATOS, Tulio; CHARYTONOWICZ, Elizabeth; HRICIK, Todd; CASTILLO-MARTIN, Mireia; REMOTTI, Fabrizio; LEE, Francis Y; MATUSHANSKY, Igor. "Characterization and comparison of the properties of sarcoma cell linesin vitroandin vivo". Human Cell 22 4 (2009): 85-93. http://dx.doi.org/10.1111/j.1749-0774.2009.00073.x.
    Publicado • 10.1111/j.1749-0774.2009.00073.x
  88. Petit, Anna; Castillo, Mireia; Gaspa, Albert; Colomer, Dolors; De Albéniz, Xabier Garcia; Moreno, Carol; Camós, Mireia; Mellado, Begoña; Mallofré, Carme. "Expression and mutational analyses of KIT and PDGFR-a in sarcomatoid renal cell carcinoma". Histopathology 55 2 (2009): 230-232. http://dx.doi.org/10.1111/j.1365-2559.2009.03342.x.
    10.1111/j.1365-2559.2009.03342.x
  89. Silva, Jose M.; Ezhkova, Elena; Silva, Javier; Heart, Stephen; Castillo, Mireia; Campos, Yolanda; Castro, Veronica; et al. "Cyfip1 Is a Putative Invasion Suppressor in Epithelial Cancers". Cell 137 6 (2009): 1047-1061. http://dx.doi.org/10.1016/j.cell.2009.04.013.
    Publicado • 10.1016/j.cell.2009.04.013
  90. Puzio-Kuter, A. M.; Castillo-Martin, M.; Kinkade, C. W.; Wang, X.; Shen, T. H.; Matos, T.; Shen, M. M.; Cordon-Cardo, C.; Abate-Shen, C.. "Inactivation of p53 and Pten promotes invasive bladder cancer". Genes & Development 23 6 (2009): 675-680. http://dx.doi.org/10.1101/gad.1772909.
    Publicado • 10.1101/gad.1772909
  91. Real, Pedro J; Tosello, Valeria; Palomero, Teresa; Castillo, Mireia; Hernando, Eva; de Stanchina, Elisa; Sulis, Maria Luisa; et al. "¿-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia". Nature Medicine 15 1 (2008): 50-58. http://dx.doi.org/10.1038/nm.1900.
    10.1038/nm.1900
  92. Karni-Schmidt, O.; Zupnick, A.; Castillo, M.; Ahmed, A.; Matos, T.; Bouvet, P.; Cordon-Cardo, C.; Prives, C.. "p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner". Journal of Cell Science 121 24 (2008): 4098-4105. http://dx.doi.org/10.1242/jcs.030098.
    Publicado • 10.1242/jcs.030098
  93. Kinkade, Carolyn Waugh; Castillo-Martin, Mireia; Puzio-Kuter, Anna; Yan, Jun; Foster, Thomas H.; Gao, Hui; Sun, Yvonne; et al. "Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model". Journal of Clinical Investigation (2008): http://dx.doi.org/10.1172/jci34764.
    Publicado • 10.1172/jci34764
  94. Voloshyna, Iryna; Besana, Alessandra; Castillo, Mireia; Matos, Tulio; Weinstein, I. Bernard; Mansukhani, Mahesh; Robinson, Richard B.; Cordon-Cardo, Carlos; Feinmark, Steven J.. "TREK-1 Is a Novel Molecular Target in Prostate Cancer". Cancer Research 68 4 (2008): 1197-1203. http://dx.doi.org/10.1158/0008-5472.can-07-5163.
    Publicado • 10.1158/0008-5472.can-07-5163
  95. Palomero, Teresa; Sulis, Maria Luisa; Cortina, Maria; Real, Pedro J; Barnes, Kelly; Ciofani, Maria; Caparros, Esther; et al. "Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia". Nature Medicine 13 10 (2007): 1203-1210. http://dx.doi.org/10.1038/nm1636.
    Publicado • 10.1038/nm1636
  96. María Manzanares, José; de Juan, Carmen; Castillo, Mireia. "Varón de 49 años con trastorno agudo de la conducta e hipopotasemia". Medicina Clínica 126 3 (2006): 110-115. http://dx.doi.org/10.1157/13083882.
    Publicado • 10.1157/13083882
  97. Castillo, M.; Sanjuan, A.; Perez, N.; Zanon, G.; Bons, N.; Vilanova, M.; Vanrell, J. A.; Merino, M. J.; Fernandez, P. L.. "Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing". International Journal of Surgical Pathology 14 1 (2006): 89-93. http://dx.doi.org/10.1177/106689690601400118.
    Publicado • 10.1177/106689690601400118
  98. Petit, Anna; Castillo, Mireia; Mellado, Bego??a; Mallofre, Carme. "c-kit Overexpression in Chromophobe Renal Cell Carcinoma Is Not Associated With c-kit Mutation of Exons 9 and 11". The American Journal of Surgical Pathology 29 11 (2005): 1544-1545. http://dx.doi.org/10.1097/01.pas.0000169501.86356.49.
    10.1097/01.pas.0000169501.86356.49
  99. Alos, Llucia; Lujan, Blanca; Castillo, Mireia; Nadal, Alfons; Carreras, Marta; Caballero, Miguel; de Bolos, Carme; Cardesa, Antonio. "Expression of Membrane-Bound Mucins (MUC1 and MUC4) and Secreted Mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in Mucoepidermoid Carcinomas of Salivary Glands". American Journal of Surgical Pathology 29 6 (2005): 806-813. http://dx.doi.org/10.1097/01.pas.0000155856.84553.c9.
    10.1097/01.pas.0000155856.84553.c9
  100. Perez, Noelia; Castillo, Mireia; Santos, Yolanda; Truan, David; Gutierrez, Rafael; Franco, Agustin; Palacin, Antonio; et al. "Carcinosarcoma of the prostate: two cases with distinctive morphologic and immunohistochemical findings". Virchows Archiv 446 5 (2005): 511-516. http://dx.doi.org/10.1007/s00428-005-1239-x.
    Publicado • 10.1007/s00428-005-1239-x
  101. Ferrer, Berta; Bermudo, Raquel; Thomson, Timothy; Nayach, Iracema; Soler, Marta; Sánchez, Montserrat; Castillo, Mireia; et al. "Paraffin-Embedded Cell Line Microarray (PECLIMA): Development and Validation of a High-Throughput Method for Antigen Profiling of Cell Lines". Pathobiology 72 5 (2005): 225-232. http://dx.doi.org/10.1159/000089416.
    Publicado • 10.1159/000089416
  102. CASTILLO, MIREIA; PETIT, ANNA; MELLADO, BEGOÑA; PALACÍN, ANTONIO; ALCOVER, JOAN B.; MALLOFRÉ, CARME. "C-KIT EXPRESSION IN SARCOMATOID RENAL CELL CARCINOMA: POTENTIAL THERAPY WITH IMATINIB". Journal of Urology 171 6 Part 1 (2004): 2176-2180. http://dx.doi.org/10.1097/01.ju.0000127727.33232.cf.
    Publicado • 10.1097/01.ju.0000127727.33232.cf
  103. Alos, L; Castillo, M; Nadal, A; Caballero, M; Mallofre, C; Palacin, A; Cardesa, A. "Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases". Histopathology 44 6 (2004): 570-579. http://dx.doi.org/10.1111/j.1365-2559.2004.01881.x.
    Publicado • 10.1111/j.1365-2559.2004.01881.x
  104. Petit, Anna; Castillo, Mireia; Santos, Mónica; Mellado, Begoña; Alcover, Joan B; Mallofré, Carme. "KIT Expression in Chromophobe Renal Cell Carcinoma". The American Journal of Surgical Pathology 28 5 (2004): 676-678. http://dx.doi.org/10.1097/00000478-200405000-00017.
    Publicado • 10.1097/00000478-200405000-00017
  105. Martínez, Antoni; Aymerich, Marta; Castillo, Mireia; Colomer, Dolors; Bellosillo, Beatriz; Campo, Elias; Villamor, Neus. "Routine use of immunophenotype by flow cytometry in tissues with suspected hematological malignancies". Cytometry Part B: Clinical Cytometry 56B 1 (2003): 8-15. http://dx.doi.org/10.1002/cyto.b.10044.
    Publicado • 10.1002/cyto.b.10044
  106. Mallofré, Carme; Castillo, Mireia; Morente, Vanesa; Solé, Manel. "Immunohistochemical Expression of CK20, p53, and Ki-67 as Objective Markers of Urothelial Dysplasia". Modern Pathology 16 3 (2003): 187-191. http://dx.doi.org/10.1097/01.mp.0000056628.38714.5d.
    Publicado • 10.1097/01.mp.0000056628.38714.5d
  107. Clarós, Pedro; Dominte, Gabriela; Clarós, Andres; Castillo, Mireia; Cardesa, Antonio. "Parotid gland mucoepidermoid carcinoma in a 4-year-old child". International Journal of Pediatric Otorhinolaryngology 63 1 (2002): 67-72. http://dx.doi.org/10.1016/s0165-5876(01)00637-1.
    Publicado • 10.1016/s0165-5876(01)00637-1
Capítulo de livro
  1. Ligeiro, Dário; Rao, Martin; Maia, Andreia; Castillo, Mireia; Beltran, Antonio; Maeurer, Markus. "B Cells in the Gastrointestinal Tumor Microenvironment with a Focus on Pancreatic Cancer: Opportunities for Precision Medicine?". In Advances in Experimental Medicine and Biology, 175-195. Springer International Publishing, 2020.
    10.1007/978-3-030-49270-0_10
  2. Carrasco-Avino, Gonzalo; Greenbaum, Benjamin; Castillo-Martin, Mireia; Firpo, Adolfo; Cordon-Cardo, Carlos; Kalir, Tamara. "Genomic Analysis of Epithelial Ovarian Cancer". In Ovarian Cancer-Challenges and Innovations, 130-147. Estados Unidos: BENTHAM SCIENCE PUBLISHERS, 2019.
    10.2174/9789811421860119010008
  3. Castillo-Martin, Mireia; Ribeiro, Joana. "Case Studies: Molecular Pathology Perspective and Impact on Oncologic Patients’ Management". In Molecular and Cell Biology of Cancer - when cells break the rules and hijack their own planet, 191-216. 2019.
    Publicado • 10.1007/978-3-030-11812-9_10
  4. Castillo-Martin, Mireia; Thin, Tin Htwe; Lorduy, Ana Collazo; Cordon-Cardo, Carlos. "Immunopathologic Assessment of PTEN Expression". In Methods in Molecular Biology, 23-37. Springer New York, 2015.
    Publicado • 10.1007/978-1-4939-3299-3_3
  5. Castillo-Martin, Mireia. "El ciclo celular y sus alteraciones en cáncer". In Aplicabilidad de la Biología Molecular en Urología, 46-68. Madrid, Espanha, 2005.
    Publicado
  6. Castillo-Martin, Mireia. "Cistitis glandular". In Patologías excepcionales en urología, 271-293. Madrid, Espanha, 2004.
    Publicado
Tradução
  1. Castillo-Martin, Mireia. 7th Edition of Robbins and Cotran Pathologic Basis of Disease. Madrid, Espanha: Elsevier Espana. 2005.
    Publicado

Propriedade Intelectual

Patente
  1. Castillo-Martin, Mireia; Cordon-Cardo, Carlos; Domingo-Doménech, Josep; Petrylak, Daniel P.. 2011. "Cancer Stem Cells, Kits, and Methods". Estados Unidos.
    Permitida
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/05/09 Neoplasias Biliares: Visão do anatomo-patologista XVI Congresso Nacional de Radiologia
Sociedade Portuguesa De Radiologia E Medicina Nuclear (Peniche, Portugal)
2023/12/06 Começar um Biobanco – experiências portuguesas Curso de formação avançada em Biobancos para países de fala portuguesa (PALOP).
Instituto de Medicina Molecular (Lisbon, Portugal)
2023/10/18 Tumores Pancreáticos. Taller SEDIA: Curso de correlación radiopatológica. Grandes retos diagnósticos. XXII Congreso SEDIA – Imagen pélvica. Abordaje multidisciplinar
Sociedad Española de Diagnóstico por Imagen del Abdomen (Salamanca, Espanha)
2023/09/22 3. A importância dos Biobancos em Oncologia 5º Encontro Nacional de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro (Porto, Portugal)
2022/11/18 Biobanco: conducta para armazenamento e utilização de amostras para investigação. Dilemas éticos em Oncologia. 19º Congresso Nacional de Oncologia
Sociedade Portuguesa de Oncologia (Porto, Portugal)
2022/10/18 PSMA Characteristics and Immunohistochemistry Expression 35th Annual Congress of the European Association of Nuclear Medicine – EANM’22
European Association of Nuclear Medicine (Barcelona, Espanha)
2022/03/30 Champalimaud Foundation Biobank Sessão BIOBANCOS II: Experiências Portuguesas
Comissão de Ética do Instituto Nacional de Saúde Doutor Ricardo Jorge (Lisbon, Portugal)
2018/05/04 Biobanco da Fundação Champalimaud - Biópsia líquida. 3rd CHAMPALIMAUD CANCER NURSE CONFERENCE
Fundação Champalimaud (Lisbon, Portugal)
2018/05 Biobanco da FC – biopsia liquida. 3º Congresso de Enfermagem da Fundação Champalimaud
(Portugal)
2018/02 To be or not to be Angels & Demons in rectal cancer: Challenging the dogmas.
Champalimaud Centre for the Unknown (Lisbon, Portugal)
2018 Comparative pathology and molecular characterization of tumors. 16th ASEICA International Congress
(Valencia, Espanha)
2016/09 ¿Np63 is critical for progression of high grade non-muscle invasive bladder cancer through deregulation of specific genetic pathways. XXXI International Congress of the International Academy of Pathology and 28th Congress of the European Society of Pathology
European Society of Pathology (Alemanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018/09/01 - 2019/08/31 3-Dimensional characterization of PanIN (pancreatic intraepithelial neoplasia) in cleared human pancreatic cancer tissues by multiplex immunofluorescence
Orientador
2016/09/01 - 2017/08/31 Oligometastatic Prostate Cancer: Characterization of its Molecular Phenotype
Orientador
2016/09/01 - 2017/08/31 ¿Np63 is Critical for Progression of High Grade Non-Muscle Invasive Bladder Cancer Through Deregulation of Specific Genetic Pathways
Orientador

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/09/28 - 2022/09/29 The CaixaResearch Health Meeting is an event designed specifically to bring together all the researchers who received a grant in the CaixaResearch Health 2018 Call. The Project Leaders and Principal Investigators of the 25 projects awarded in any of the 5 areas (Neuroscience, Oncology, Cardiovascular and Metabolic Diseases, Infectious Diseases and Enabling Technologies) are invited to create a multidisciplinary discussion of hot topics in Life Sciences and to share their ideas and experiences for 2 days.
Encontro
 1st CaixaResearch Health meeting
Fundação 'la Caixa', Portugal
2021/12/15 - 2021/12/15 Volunteer in the Mentorship program “Ciência di Noz Manera”, performing a workshop on Cell Biology for 8th and 9th graders at the Escola Pedro D’Orey da Cunha in Damaia (Lisbon suburbs), to promote science in underserved communities, with focus in STEM groups.
Oficina (workshop)
 Ciência di Noz Manera
2019/11/15 - 2019/11/15 Moderator in the Pancreatic Cancer – From Cell Biology to Treatment. Session III. Symposium on Imaging Hallmarks of Cancer. Fundação Champalimaud
Conferência
 Symposium on Imaging Hallmarks of Cancer
Fundação Champalimaud, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/11/25 Unravelling how melanoma extracellular vesicles establish pre-metastatic niches in the lung
Arguente principal
 Maria João Teixeira da Costa de Almeida (Mestrado)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2024/09 The Potential of Natural Killer cells in Pancreatic Cancer: from Exploring Tumor-infiltrating Lymphocytes to novel CAR-NK cell Therapy
Orientador
 Andreia Filipa Garrido Maia (Doutoramento)
Universidade Nova de Lisboa Medical School, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2022/05/27 - 2022/05/28 XV Congrés de la Societat Catalana d’Anatomia Patològica Societat Catalana d'Anatomia Patològica

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019/07/01 - Atual The Journal of Pathology (1096-9896) Wiley (John Wiley & Sons)
2015/05/01 - Atual SpringerPlus (2193-1801) Springer (Biomed Central Ltd.)
2014/07/01 - Atual PLoS ONE (1932-6203) Public Library of Science
2013/02/01 - Atual Journal of Dermatological Science
2011/07/01 - Atual European Urology

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019/10 - Atual Multispectral microscopy for tumor characterization. (Doutoramento) Programa Champalimaud de Neurociências, Portugal
2019/06 - Atual Biobanks: Best practices for specimen collection, processing and storage.
2017/06 - Atual Que futuro para os biobancos? Sustentabilidade dos biobancos. Privados vs. Públicos.
2024/10/09 - 2024/10/09 Mesa Redonda: Começar um biobanco – experiências portuguesas. (Outros) Gulbenkian Institute for Molecular Medicine, Portugal
2021/02/22 - 2021/02/22 Molecular Pathology. Impact in oncological patient's management. (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal

Membro de associação

Nome da associação Tipo de participação
2022/02/10 - Atual • Graduate Women in Science (GWIS) member
2016/02/01 - Atual European Association of Cancer research (EACR) Member
2016/02/01 - Atual Associação Portuguesa de Investigação em Cancro (ASPIC) Member
2013/10/01 - Atual International Society of Urological Pathology (ISUP) Member
2013/03/01 - Atual American Association of Cancer Research (AACR) Member
2011/12/01 - Atual United States and Canadian Academy of Pathology (USCAP) Member
2002/05/01 - Atual Societat Catalana de Citopatologia Member
2002/05/01 - Atual Societat Catalana d’Anatomia Patologica Member
1998/09/01 - Atual Academia de Ciències Mèdiques de Catalunya i Balears Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021/01/01 - 2024/01/05 Member of the PhD thesis Committe of Julia Elzanowska entitled “Extracellular Vesicles Molecular Cargo as Cancer Biomarkers: Insights into EV-DNA Preparation and EV Protein Interactions”. Defended on the 5th of January 2024
Membro
 Fundação Champalimaud, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023/12/19 - 2023/12/19 Jury of the Master Thesis by Inês Saldanha entitled “Extracellular Vesicles as biomarkers of hepatic metastasis in pancreatic cancer patients”. Defended on the 19th of December Fundação Champalimaud, Portugal

Tutoria

Tópico Nome do aluno
2024/03/01 - 2028/03/31 Clinical implications of pathologic response to radiotherapy in rectal cancer José Gonçalves Moreira de Azevedo
2022/09/01 - 2024/11/13 Can response to chemotherapy be predicted by studying inflammatory cells in the tumour microenvironment of pancreatic cancer? Andreia Lopes
2020/01/01 - 2024/03/01 Expansion of Natural Killer cells as a complementary approach for adoptive cell therapy in advanced Colorectal Cancer (NKAT-CRC) Andreia Filipa Garrido Maia
2021/10/04 - 2023/11/19 Characterisation of the colon adenocarcinoma microenvironment with a focus on Natural Killer cells Hasti António Meggi Calá
2020/09/01 - 2021/08/31 Unraveling the importance of HLA class I in colorectal cancer cell stemness and tumor initiation Ana Raquel Borralho
2020/09/01 - 2021/08/31 Molecular phenotyping of prostate cancer microenvironment, with emphasis in fibroblast activation Sara Cascais
2019/09/01 - 2021/08/31 Do MHC Class I Negative Tumour Cells Display the Cancer Stem Cell Property of Chemoresistance? Unravelling the Mechanisms Cátia Rebelo
2019/07/01 - 2020/06/30 Immune infiltrates analysis for prediction of response to chemoradiotherapy in rectal cancer Inês Franco
2018/09/01 - 2019/08/31 3-Dimensional characterization of PanIN (pancreatic intraepithelial neoplasia) in cleared human pancreatic cancer tissues by multiplex immunofluorescence Susana Canastra Dias
2019/02/01 - 2019/05/31 Immune infiltrates analysis for prediction of response to chemoradiotherapy in rectal cancer Ana Borralho
2016/09/01 - 2017/08/31 Oligometastatic Prostate Cancer: Characterization of its Molecular Phenotype Sara Trinidade Correia
2016/09/01 - 2017/08/31 ¿Np63 is Critical for Progression of High Grade Non-Muscle Invasive Bladder Cancer Through Deregulation of Specific Genetic Pathways Andreia Filipa Garrido Maia
Distinções

Prémio

2020 Menção Honrosa for the project entitled: Expansion of Natural Killer cells as a complementary approach for adoptive cell therapy in advanced Colorectal and Pancreatic Cancer (NKAT-CRC-PDAC).
2020 Menção Honrosa for the project entitled: Zebrafish Avatars, towards personalized cancer treatment.
2017 Image of the Month Award- September 2017
European Association For Cancer Research, Reino Unido
2012 Young Physician-Scientist Award
SASS Foundation, Estados Unidos
2002 Award at the end of Residency
Hospital Clínic de Barcelona, Espanha