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My academic career has been predicated on the bench-to-bedside-to-bench paradigm in Hematology. Over the last 25 years, I have been engaged in translational research focusing on immunotherapy approaches to improve the outcome of hematological malignancies, with an emphasis on antibody-based therapeutics, hematopoietic stem cell transplantation and adoptive T-cell transfer for acute leukemia. I have an extensive track record of leading studies that involve a strong correlative component and collaborating with other investigators both basic and clinical. I joined Nottingham Trent University in September 2016 as the Professor of Cancer Immunotherapy to establish a translational research program, the focus of which is on visualising the state of leukemia-immune system interactions using high-dimensional gene and protein expression data and to use this information to design rational immunotherapy approaches. I have enhanced the creativity of research in the School and the University by introducing state-of-the-art methodologies (targeted gene expression profiling, highly multiplexed spatially resolved digital immunohistochemistry) to address previously unexplored research questions. I have received merit awards from the American Association of Immunologists and the 2019 Vice Chancellor’s Outstanding Researcher Award from NTU, and I have published 209 peer-reviewed papers (H-index=53; i10-index=161; times cited=9,700; total impact factor>1,220), 13 book chapters and >300 conference abstracts. I have secured £4,122,718 of research funding from research charities, government bodies and commercial entities. I currently teach Immunology and Virology at undergraduate and postgraduate level and I provide research mentorship and leadership in the area of cancer immunology and therapeutics.
Identificação

Identificação pessoal

Nome completo
Sergio Rutella

Nomes de citação

  • Rutella, Sergio

Identificadores de autor

Ciência ID
D312-CAE4-12E6
ORCID iD
0000-0003-1970-7375

Endereços de correio eletrónico

  • sergio.rutella@gmail.com (Pessoal)

Telefones

Telemóvel
  • (+44) 7503000479 (Pessoal)

Moradas

  • Clifton Campus, NG11 8NS, Nottingham, Nottingham, Reino Unido (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Hematologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Italiano (Idioma materno)
Formação
Grau Classificação
1997/11/01 - 2001/02/28
Concluído
Experimental Haematology (Dottorato di Ricerca)
Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Itália
1993/10/01 - 1997/11/20
Concluído
Specialisation in Haematology (Postgraduate Certificate)
Especialização em Summa cum laude
Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Itália
1986/10/01 - 1993/02/25
Concluído
Medicina e Chirurgia (Laurea)
Especialização em Summa cum laude
Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Itália
"Effect of all-trans retinoic acid on the coagulopathy associated with acute promyelocytic leukaemia." (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2016/09/01 - Atual Investigador principal (carreira) (Investigação) Nottingham Trent University - Clifton Campus, Reino Unido
Nottingham Trent University School of Science and Technology, Reino Unido

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2014/09/28 - 2016/06/23 Executive Director of Clinical Research Sidra Medical and Research Center, Catar
2012/08/01 - 2014/08/31 Head of Service, Immunohaematology and Transfusion Medicine Ospedale Pediatrico Bambino Gesù, Itália

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2011/08/01 - 2012/07/31 Consultant Haematologist Ospedale Pediatrico Bambino Gesù, Itália
Ospedale Pediatrico Bambino Gesù, Itália
2000/11/01 - 2011/07/31 Consultant Haematologist Policlinico Universitario Agostino Gemelli, Itália
Università Cattolica del Sacro Cuore Facoltà di Medicina e Chirurgia, Itália
Projetos

Bolsa

Designação Financiadores
2016/08/01 - 2020/08/31 Microenvironmental targets for restoring anti-tumor immunity in childhood acute leukemia
NPRP8-2297-3-494
Qatar National Research Fund
Concluído
2012/01 - 2015/01 Alterazioni dellâ RNA Editing A-to-I nelle leucemie mieloidi acute nuove strategie diagnostiche e terapeutiche Ministero dell'Istruzione dell'Università e della Ricerca
2011/11 - 2014/08 Design of GMP-compliant strategies to expand mesenchymal stromal cells for clinical use
N/A
Finanziaria Laziale di Sviluppo
2009/01 - 2011/12 Hepatocyte growth factor and immune dysfunction in multiple myeloma
IG#8556
Associazione Italiana Ricerca sul Cancro
2009/01 - 2011/01 Meccanismi di immunosoppressione/tolleranza nell'interazione tumore e sistema immunitario identificazione di nuove strategie per ristabilire l'immunosorveglianza. Ministero dell'Istruzione dell'Università e della Ricerca
Produções

Publicações

Artigo em revista
  1. Sergio Rutella; Jayakumar Vadakekolathu; Francesco Mazziotta; Stephen Reeder; Tung-On Yau; Rupkatha Mukhopadhyay; Benjamin Dickins; et al. "Signatures of immune dysfunction predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia". Journal of Clinical Investigation (2022): https://doi.org/10.1172/JCI159579.
    10.1172/JCI159579
  2. Tung On Yau; Jayakumar Vadakekolathu; Gemma Ann Foulds; Guodong Du; Benjamin Dickins; Christos Polytarchou; Sergio Rutella. "Hyperactive neutrophil chemotaxis contributes to anti-tumor necrosis factor-a treatment resistance in inflammatory bowel disease". Journal of Gastroenterology and Hepatology 37 3 (2022): 531-541. https://doi.org/10.1111/jgh.15764.
    10.1111/jgh.15764
  3. Raquel Alves; Ana Cristina Gonçalves; Sergio Rutella; António M. Almeida; Javier De Las Rivas; Ioannis P. Trougakos; Ana Bela Sarmento Ribeiro. "Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia—From Molecular Mechanisms to Clinical Relevance". Cancers 13 19 (2021): 4820-4820. https://doi.org/10.3390/cancers13194820.
    10.3390/cancers13194820
  4. Laura Lestón Pinilla; Aslihan Ugun-Klusek; Sergio Rutella; Luigi A. De Girolamo. "Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”". Biology 10 8 (2021): 723-723. https://doi.org/10.3390/biology10080723.
    10.3390/biology10080723
  5. Uy, Geoffrey L.; Aldoss, Ibrahim; Foster, Matthew C.; Sayre, Peter H.; Wieduwilt, Matthew J.; Advani, Anjali S.; Godwin, John E.; et al. "Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia". Blood 137 6 (2021): 751-762. http://dx.doi.org/10.1182/blood.2020007732.
    10.1182/blood.2020007732
  6. Raquel Alves; Stephanie E. B. McArdle; Jayakumar Vadakekolathu; Ana Cristina Gonçalves; Paulo Freitas-Tavares; Amélia Pereira; Antonio M. Almeida; Ana Bela Sarmento-Ribeiro; Sergio Rutella. "Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-a". Journal of Translational Medicine (2020): https://doi.org/10.1186/s12967-019-02194-x.
    10.1186/s12967-019-02194-x
  7. Cesano, Alessandra; Cannarile, Michael A; Gnjatic, Sacha; Gomes, Bruno; Guinney, Justin; Karanikas, Vaios; Karkada, Mohan; et al. "Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II—practical challenges". Journal for ImmunoTherapy of Cancer 8 2 (2020): e001472. http://dx.doi.org/10.1136/jitc-2020-001472.
    10.1136/jitc-2020-001472
  8. Rutella, Sergio; Cannarile, Michael A; Gnjatic, Sacha; Gomes, Bruno; Guinney, Justin; Karanikas, Vaios; Karkada, Mohan; et al. "Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I—conceptual challenges". Journal for ImmunoTherapy of Cancer 8 2 (2020): e001389. http://dx.doi.org/10.1136/jitc-2020-001389.
    10.1136/jitc-2020-001389
  9. Rutella, Sergio. "Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy.". Frontiers in Immunology (2020): https://europepmc.org/articles/PMC7064638.
    10.3389/fimmu.2020.00364
  10. Rutella, Sergio. "TP53 abnormalities correlate with immune infiltration and are associated with response to flotetuzumab, an investigational immunotherapy, in acute myeloid leukemia". [] (2020): http://dx.doi.org/10.1101/2020.02.28.961391.
    10.1101/2020.02.28.961391
  11. Rutella, Sergio. "Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia". [] (2019): http://dx.doi.org/10.1101/702001.
    10.1101/702001
  12. Sarah Wagner; Jayakumar Vadakekolathu; Sarah K. Tasian; Heidi Altmann; Martin Bornhäuser; A. Graham Pockley; Graham R. Ball; Sergio Rutella. "A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study". Blood Advances 3 8 (2019): 1330-1346. https://doi.org/10.1182/bloodadvances.2018030726.
    10.1182/bloodadvances.2018030726
  13. Rutella, Sergio. "Reverting Immune Suppression to Enhance Cancer Immunotherapy.". Frontiers in Oncology (2019): https://europepmc.org/articles/PMC6985581.
    10.3389/fonc.2019.01554
  14. Jan Davidson-Moncada; Elena Viboch; Sarah Church; Sarah Warren; Sergio Rutella. "Dissecting the Immune Landscape of Acute Myeloid Leukemia". Biomedicines 6 4 (2018): 110-110. https://doi.org/10.3390/biomedicines6040110.
    10.3390/biomedicines6040110
  15. Sarah Tasian; Martin Bornhäuser; Sergio Rutella. "Targeting Leukemia Stem Cells in the Bone Marrow Niche". Biomedicines 6 1 (2018): 22-22. https://doi.org/10.3390/biomedicines6010022.
    10.3390/biomedicines6010022
  16. Rutella, Sergio. "Capturing the complexity of the immune microenvironment of acute myeloid leukemia with 3D biology technology.". Journal of Clinical Oncology (2018): http://dx.doi.org/10.1200/jco.2018.36.5_suppl.50.
    10.1200/jco.2018.36.5_suppl.50
  17. Dimitrios Zafeiris; Sergio Rutella; Graham Roy Ball. "An Artificial Neural Network Integrated Pipeline for Biomarker Discovery Using Alzheimer's Disease as a Case Study". Computational and Structural Biotechnology Journal 16 (2018): 77-87. https://doi.org/10.1016/j.csbj.2018.02.001.
    10.1016/j.csbj.2018.02.001
  18. Matlung, H.L.; Babes, L.; Zhao, X.W.; van Houdt, M.; Treffers, L.W.; van Rees, D.J.; Franke, K.; et al. "Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis". Cell Reports 23 13 (2018): 3946-3959.e6. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048859204&partnerID=MN8TOARS.
    10.1016/j.celrep.2018.05.082
  19. Pockley, A.G.; Lindsay, J.O.; Foulds, G.A.; Rutella, S.; Gribben, J.G.; Alexander, T.; Snowden, J.A.. "Immune reconstitution after autologous hematopoietic stem cell transplantation in Crohn's disease: Current status and future directions. A review on behalf of the EBMT autoimmune diseases working party and the autologous stem cell transplantation in refractory CD-Low Intensity Therapy Evaluation study investigators". Frontiers in Immunology 9 APR (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85045004182&partnerID=MN8TOARS.
    10.3389/fimmu.2018.00646
  20. Foulds, G.A.; Vadakekolathu, J.; Abdel-Fatah, T.M.A.; Nagarajan, D.; Reeder, S.; Johnson, C.; Hood, S.; et al. "Immune-phenotyping and transcriptomic profiling of peripheral blood mononuclear cells from patients with breast cancer: Identification of a 3 gene signature which predicts relapse of triple negative breast cancer". Frontiers in Immunology 9 SEP (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053153382&partnerID=MN8TOARS.
    10.3389/fimmu.2018.02028
  21. Dimitrios Zafeiris; Jayakumar Vadakekolathu; Sarah Wagner; Alan Graham Pockley; Graham Roy Ball; Sergio Rutella. "Discovery and application of immune biomarkers for hematological malignancies". Expert Review of Molecular Diagnostics (2017): 1-18. https://doi.org/10.1080/14737159.2017.1381560.
    10.1080/14737159.2017.1381560
  22. Rutella, Sergio. "T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation". Biomedicines (2017): http://www.mdpi.com/2227-9059/5/2/33.
    10.3390/biomedicines5020033
  23. Stroncek DF; Butterfield LH; Cannarile MA; Dhodapkar MV; Greten TF; Grivel JC; Kaufman DR; et al. "Systematic evaluation of immune regulation and modulation.". (2017): http://europepmc.org/abstract/med/28331613.
    10.1186/s40425-017-0223-8
  24. Ženka J; Caisová V; Uher O; Nedbalová P; Kvardová K; Masáková K; Krejcová G; et al. "Abstracts from the 4th ImmunoTherapy of Cancer Conference: Prague, Czech Republic. 20–22 March 2017.". (2017): http://europepmc.org/abstract/PMC/PMC5374589.
  25. Raffaele Frazzi; Charles Auffray; Angela Ferrari; Perla Filippini; Sergio Rutella; Alfredo Cesario. "Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies". Journal of Translational Medicine 14 1 (2016): http://dx.doi.org/10.1186/s12967-016-1018-2.
    10.1186/s12967-016-1018-2
  26. Deola, S.; Cugno, C.; Comoli, P.; Guido, I.; Rubert, L.; Zecca, M.; Zanolini, D.; et al. "Evidence for CD19B–CD8T cell interactions in blood and tissues from patients with GvHD". Bone Marrow Transplantation (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84994673834&partnerID=MN8TOARS.
    10.1038/bmt.2016.294
  27. Sala E; Genua M; Petti L; Anselmo A; Arena V; Cibella J; Zanotti L; et al. "Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine.". (2015): http://europepmc.org/abstract/med/25790743.
    10.1053/j.gastro.2015.03.013
  28. Genua M; D'Alessio S; Cibella J; Gandelli A; Sala E; Correale C; Spinelli A; et al. "The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation.". (2015): http://europepmc.org/abstract/med/24848264.
    10.1136/gutjnl-2013-305933
  29. Locatelli F; Masetti R; Rondelli R; Zecca M; Fagioli F; Rovelli A; Messina C; et al. "Outcome of children with high-risk acute myeloid leukemia given autologous or allogeneic hematopoietic cell transplantation in the aieop AML-2002/01 study.". (2015): http://europepmc.org/abstract/med/25387094.
    10.1038/bmt.2014.246
  30. Piscaglia AC; Rutella S; Laterza L; Cesario V; Campanale M; Cazzato IA; Ianiro G; et al. "Circulating hematopoietic stem cells and putative intestinal stem cells in coeliac disease.". (2015): http://europepmc.org/abstract/med/26160352.
    10.1186/s12967-015-0591-0
  31. Pittari G; Filippini P; Gentilcore G; Grivel JC; Rutella S. "Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies.". (2015): http://europepmc.org/abstract/med/26029215.
    10.3389/fimmu.2015.00230
  32. Yadav SK; Gupta RK; Saraswat VA; Rangan M; Thomas MA; Rutella S; Danese S; et al. "Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology.". (2015): http://europepmc.org/abstract/med/26444271.
    10.1186/s12967-015-0679-6
  33. Locatelli, F.; Masetti, R.; Rondelli, R.; Zecca, M.; Fagioli, F.; Rovelli, A.; Messina, C.; et al. "Erratum: Outcome of children with high-risk acute myeloid leukemia given autologous or allogeneic hematopoietic cell transplantation in the AIEOP AML-2002/01 study (Bone Marrow Transplantation (2015) 15 (320))". Bone Marrow Transplantation 50 2 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84922322688&partnerID=MN8TOARS.
    10.1038/bmt.2014.291
  34. Cugno, C.; Deola, S.; Filippini, P.; Stroncek, D.F.; Rutella, S.; Cugno C; Deola S; et al. "Granulocyte transfusions in children and adults with hematological malignancies: Benefits and controversies". Journal of Translational Medicine 13 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84960462980&partnerID=MN8TOARS.
    10.1186/s12967-015-0724-5
  35. Li Pira G; Ivaldi F; Starc N; Landi F; Rutella S; Locatelli F; Sacchi N; Tripodi G; Manca F. "A registry of HLA-typed donors for production of virus-specific CD4 and CD8 T lymphocytes for adoptive reconstitution of immune-compromised patients.". (2014): http://europepmc.org/abstract/med/25041366.
    10.1111/trf.12754
  36. Filippini P; Rutella S. "Recent advances on cellular therapies and immune modulators for graft-versus-host disease.". (2014): http://europepmc.org/abstract/med/25196777.
    10.1586/1744666X.2014.955475
  37. Di Nardo M; Locatelli F; Di Florio F; Cecchetti C; Amodeo A; Rutella S; Bertaina A. "Extracorporeal membrane oxygenation as a bridge to allogeneic T-cell depleted hematopoietic stem cell transplantation in infants with severe combined immune deficiency: is it feasible?". (2014): http://europepmc.org/abstract/med/25112503.
    10.1007/s00134-014-3432-3
  38. Bertaina A; Merli P; Rutella S; Pagliara D; Bernardo ME; Masetti R; Pende D; et al. "HLA-haploidentical stem cell transplantation after removal of aß+ T and B cells in children with nonmalignant disorders.". (2014): http://europepmc.org/abstract/med/24869942.
    10.1182/blood-2014-03-563817
  39. Rutella, Sergio. "TUMOUR BIOLOGY.". (2014): http://europepmc.org/abstract/PMC/PMC4046298.
  40. Rutella S; Valentini CG; Ceccarelli S; Romano MT; Brescia LP; Milano GM; Locatelli F. "Extracorporeal photopheresis for paediatric patients experiencing graft-versus-host disease (GVHD).". (2014): http://europepmc.org/abstract/med/24780391.
    10.1016/j.transci.2014.04.004
  41. Li Pira G; Ivaldi F; Starc N; Landi F; Locatelli F; Rutella S; Tripodi G; Manca F. "Miniaturized and high-throughput assays for analysis of T-cell immunity specific for opportunistic pathogens and HIV.". (2014): http://europepmc.org/abstract/med/24477854.
    10.1128/CVI.00660-13
  42. Genua M; Rutella S; Correale C; Danese S. "The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis.". (2014): http://europepmc.org/abstract/med/25347935.
    10.1186/s12967-014-0293-z
  43. Rutella S; Filippini P; Bertaina V; Li Pira G; Altomare L; Ceccarelli S; Brescia LP; et al. "Mobilization of healthy donors with plerixafor affects the cellular composition of T-cell receptor (TCR)-aß/CD19-depleted haploidentical stem cell grafts.". (2014): http://europepmc.org/abstract/med/25179788.
    10.1186/s12967-014-0240-z
  44. Di Nardo, M.; Li Pira, G.; Amodeo, A.; Cecchetti, C.; Giorda, E.; Ceccarelli, S.; Brescia, L.P.; et al. "Adoptive immunotherapy with antigen-specific T cells during extracorporeal membrane oxygenation (ECMO) for adenovirus-related respiratory failure in a child given haploidentical stem cell transplantation". Pediatric Blood and Cancer 61 2 (2014): 376-379. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890863790&partnerID=MN8TOARS.
    10.1002/pbc.24753
  45. Di Nardo, M.; Locatelli, F.; Palmer, K.; Amodeo, A.; Lorusso, R.; Belliato, M.; Cecchetti, C.; et al. "Extracorporeal membrane oxygenation in pediatric recipients of hematopoietic stem cell transplantation: an updated analysis of the Extracorporeal Life Support Organization experience". Intensive Care Medicine (2014): 1-3. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893926762&partnerID=MN8TOARS.
    10.1007/s00134-014-3240-9
  46. Van De Vijver, E.; Tool, A.T.J.; Sanal, Ö.; Çetin, M.; Ünal, S.; Aytac, S.; Seeger, K.; et al. "Kindlin-3-independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III". Journal of Allergy and Clinical Immunology 133 4 (2014): 1215-1218. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897412977&partnerID=MN8TOARS.
    10.1016/j.jaci.2013.10.020
  47. Masetti, R.; Togni, M.; Astolfi, A.; Pigazzi, M.; Indio, V.; Rivalta, B.; Manara, E.; et al. "Whole transcriptome sequencing of a paediatric case of de novo acute myeloid leukaemia with del(5q) reveals RUNX1-USP42 and PRDM16-SKI fusion transcripts". British Journal of Haematology (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84896588798&partnerID=MN8TOARS.
    10.1111/bjh.12855
  48. Folgiero, V.; Goffredo, B.M.; Filippini, P.; Masetti, R.; Bonanno, G.; Caruso, R.; Bertaina, V.; et al. "Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia". Oncotarget 5 8 (2014): 2052-2064. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899544576&partnerID=MN8TOARS.
  49. Balduzzi A; Basso G; Fagioli F; Favre C; Foà R; Lanino E; Locatelli F; et al. "Hematopoietic stem cell transplantation for children with high-risk acute lymphoblastic leukemia in first complete remission: a report from the AIEOP registry.". (2013): http://europepmc.org/abstract/med/23445874.
    10.3324/haematol.2012.079707
  50. Danese S; Rutella S; Vetrano S. "Mesenchymal stromal cells in inflammatory bowel disease: conspirators within the 'colitogenic niche'?". (2013): http://europepmc.org/abstract/med/23263523.
    10.1136/gutjnl-2012-303903
  51. Basso G; Biondi A; Casale F; Fagioli F; Lo Nigro L; Locatelli F; Luciani M; et al. "Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia.". (2013): http://europepmc.org/abstract/med/23673857.
    10.1182/blood-2013-03-491621
  52. Rutella S; Folgiero V; Filippini P; Bertaina V; Masetti R; Zecca M; Pira GL; et al. "Indoleamine 2,3-dioxygenase-1 (IDO1) expression by childhood acute myeloid leukemias inhibits T-cell production of IFN-¿ and confers an unfavorable prognosis.". (2013): http://europepmc.org/abstract/PMC/PMC3990306.
  53. De Cuyper, I.M.; Meinders, M.; Van De Vijver, E.; De Korte, D.; Porcelijn, L.; De Haas, M.; Eble, J.A.; et al. "A novel flow cytometry-based platelet aggregation assay". Blood 121 10 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876459471&partnerID=MN8TOARS.
    10.1182/blood-2012-06-437723
  54. Correale, C.; Genua, M.; Vetrano, S.; Mazzini, E.; Martinoli, C.; Spinelli, A.; Arena, V.; et al. "Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response". Gastroenterology 144 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84881191683&partnerID=MN8TOARS.
    10.1053/j.gastro.2012.10.040
  55. Biscetti, F.; Pecorini, G.; Straface, G.; Arena, V.; Stigliano, E.; Rutella, S.; Locatelli, F.; et al. "Cilostazol promotes angiogenesis after peripheral ischemia through a VEGF-dependent mechanism". International Journal of Cardiology 167 3 (2013): 910-916. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880923164&partnerID=MN8TOARS.
    10.1016/j.ijcard.2012.03.103
  56. Iachininoto, M.G.; Nuzzolo, E.R.; Bonanno, G.; Mariotti, A.; Procoli, A.; Locatelli, F.; De Cristofaro, R.; Rutella, S.. "Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells". Molecules 18 9 (2013): 10132-10145. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885090543&partnerID=MN8TOARS.
    10.3390/molecules180910132
  57. Locatelli, F.; Moretta, F.; Rutella, S.. "Management of relapsed acute lymphoblastic leukemia in childhood with conventional and innovative approaches". Current Opinion in Oncology 25 6 (2013): 707-715. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885429550&partnerID=MN8TOARS.
    10.1097/CCO.0000000000000011
  58. Ciarapica, R.; De Salvo, M.; Carcarino, E.; Bracaglia, G.; Adesso, L.; Leoncini, P.P.; Dall'Agnese, A.; et al. "The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)". Oncogene (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84887102995&partnerID=MN8TOARS.
    10.1038/onc.2013.471
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  176. Pierelli, L.; Marone, M.; Bonanno, G.; Mozzetti, S.; Rutella, S.; Morosetti, R.; Rumi, C.; et al. "Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-ß1 is a cell cycle-independent effect and influences their hematopoietic potential". Blood 95 10 (2000): 3001-3010. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034657830&partnerID=MN8TOARS.
  177. Rutella, S.; Rumi, C.; Pierelli, L.; Morosetti, R.; Sica, S.; Bonanno, G.; Scambia, G.; Leone, G.. "Granulocyte colony-stimulating factor perturbs lymphocyte mitochondrial function and inhibits cell cycle progression". Experimental Hematology 28 6 (2000): 612-625. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034086855&partnerID=MN8TOARS.
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  178. Rutella, S.; Rumi, C.; Sica, S.; Leone, G.; Reyes, E.; Bernstein, E.D.; Alvarez-Mon, M.. "Induction of T-cell mitogenic unresponsiveness by recombinant human granulocyte colony-stimulating factor (rHuG-CSF) (multiple letters)". British Journal of Cancer 82 9 (2000): 1610-1611. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034113545&partnerID=MN8TOARS.
  179. Teofili, L.; Morosetti, R.; Martini, M.; Urbano, R.; Putzulu, R.; Rutella, S.; Pierelli, L.; Leone, G.; Larocca, L.M.. "Expression of cyclin-dependent kinase inhibitor p15(INK4B) during normal and leukemic myeloid differentiation". Experimental Hematology 28 5 (2000): 519-526. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034104765&partnerID=MN8TOARS.
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  180. Rutella, S.; Bonanno, G.; Pierelli, L.; Sorà, F.; Sica, S.; Scambia, G.; D'Onofrio, G.; Rumi, C.; Leone, G.. "Enhanced susceptibility to apoptosis in T cells recovering after autologous peripheral blood progenitor cell transplantation: Reversal by interleukin-15". Cytokines, Cellular and Molecular Therapy 6 4 (2000): 189-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034431926&partnerID=MN8TOARS.
  181. Rutella, S.; Plerelli, L.; Bonanno, G.; Scambla, G.; Leone, G.; Rumi, C.. "Homogeneous expression of CXC chemokine receptor 4 (CXCR4) on G-CSF- mobilized peripheral blood CD34+ cells [2]". Blood 95 12 (2000): 4015-4016. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034660404&partnerID=MN8TOARS.
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  183. Rutella, S.; Rumi, C.; Puggioni, P.; Barberi, T.; Di Mario, A.; Larocca, L.M.; Leone, G.. "Expression of thrombospondin receptor (CD36) in B-cell chronic lymphocytic leukemia as an indicator of tumor cell dissemination". Haematologica 84 5 (1999): 419-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032874826&partnerID=MN8TOARS.
  184. Rutella, S.; Rumi, C.; Lucia, M.B.; Barberi, T.; Puggioni, P.L.; Lai, M.; Romano, A.; Cauda, R.; Leone, G.. "Induction of CD69 antigen on normal CD4+ and CD8+ lymphocyte subsets and its relationship with the phenotype of responding T-cells". Communications in Clinical Cytometry 38 3 (1999): 95-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033564671&partnerID=MN8TOARS.
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  187. Cauda, R.; Lucia, M.B.; Marasca, G.; Rutella, S.; Petrucci, M.T.; La Verde, G.; Gastaldi, R.. "Beneficial effect of highly active antiretroviral therapy (HAART) in reducing both HIV viral load and monoclonal gammopathy [1]". European Journal of Haematology 63 2 (1999): 134-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032794347&partnerID=MN8TOARS.
  188. Equitani, F.; Mele, L.; Rutella, S.; Belli, P.; Paciaroni, K.; Piscitelli, R.; Pagano, L.. "Atypical Sweet's syndrome in a neutropenic patient with acute myeloid leukemia, secondary to a RAEB-T, simulating thrombophlebitis". Panminerva Medica 41 3 (1999): 261-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033191993&partnerID=MN8TOARS.
  189. Rutella, S.; Rumi, C.; Lucia, M.B.; Etuk, B.; Cauda, R.; Leone, G.. "Flow cytometric detection of perforin in normal human lymphocyte subpopulations defined by expression of activation/differentiation antigens". Immunology Letters 60 1 (1998): 51-55. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031938788&partnerID=MN8TOARS.
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  190. Laurenti, L.; Sica, S.; Salutari, P.; Rutella, S.; Serafini, R.; D'Onofrio, G.; Rumi, C.; Leone, G.. "Assessment of hematological and immunological function during long-term follow-up after peripheral blood stem cell transplantation". Haematologica 83 2 (1998): 138-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031916451&partnerID=MN8TOARS.
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  193. Rutella, S.; Rumi, C.; Lucia, M.B.; Sica, S.; Cauda, R.; Leone, G.. "Serum of healthy donors receiving granulocyte colony-stimulating factor induces T cell unresponsiveness". Experimental Hematology 26 11 (1998): 1024-1033. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031722397&partnerID=MN8TOARS.
  194. Rumi, C.; Rutella, S.; Bonini, S.; Lambiase, A.; Sica, S.; Puggioni, P.; Salutari, P.; Etuk, B.; Leone, G.. "Immunophenotypic profile of peripheral blood eosinophils in acute graft- vs.-host disease". Experimental Hematology 26 2 (1998): 170-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031914099&partnerID=MN8TOARS.
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  201. Lucia, M.B.; Rutella, S.; Rumi, C.; Cauda, R.. "Lack of correlation between HLA-DR and CD25 "activation" related antigens on CD16+ NK cells in HIV infection.". European journal of histochemistry : EJH 41 Suppl 2 (1997): 31-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544394073&partnerID=MN8TOARS.
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  205. Rutella, S.; Rumi, C.; Lucia, M.B.; Cauda, R.; Leone, G.. "Phenotypic heterogeneity of PHA-activated CD69+ lymphocytes: the expression of APO-1/FAS antigen (CD95) and perforins identifies different functional subsets.". European journal of histochemistry : EJH 41 Suppl 2 (1997): 117-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031292460&partnerID=MN8TOARS.
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  212. Rutella, S.; Rumi, C.; Sica, S.; d'Onofrio, G.; Leone, G.. "CD44 (H-CAM) is differently expressed on circulating and bone marrow hairy cells.". European journal of histochemistry : EJH 41 Suppl 2 (1997): 49-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031292063&partnerID=MN8TOARS.
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Atividades

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2020/03/01 - Atual Translational Research Fellowship, Irish Cancer Society
Avaliador
Irish Cancer Society, Irlanda
2019/06/01 - Atual Scientific Advisory Board, Institute for Advanced Biosciences (IAB)
Avaliador
Institut pour l'Avancée des Biosciences, França
2017/09/01 - Atual Scientific Advisory Board, Collaborative Research Centre Programme
Avaliador
Deutsche Forschungsgemeinschaft, Alemanha
2017/06/01 - Atual Sparkathon Fellowship
Avaliador
Society for Immunotherapy of Cancer, Estados Unidos
2016/06/01 - Atual Genentech Basic Fellowship, SITC
Avaliador
Society for Immunotherapy of Cancer, Estados Unidos
2015/06/01 - Atual European Research Council (ERC) Starting Grants
Avaliador
European Research Council, Bélgica

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2018/10/01 - Atual Clinical & Biomarker Data Sharing Subcommittee, SITC
Membro
Society for Immunotherapy of Cancer, Estados Unidos
2014/01/01 - Atual Biomarkers Task Force (WG3), SITC
Membro
Society for Immunotherapy of Cancer, Estados Unidos
2021/01/14 - 2021/01/15 Collaborative Research Centre at University of Freiburg
Consultor
Deutsche Forschungsgemeinschaft, Alemanha
2018/01/25 - 2018/01/26 Collaborative Research Centre at University of Munich
Consultor
Distinções

Prémio

2022 Elected Fellow
The Royal Society of Biology, Reino Unido
2019 Outstanding Researcher Award
Nottingham Trent University, Reino Unido
2011 Junior Faculty Award
American Association of Immunologists Inc, Estados Unidos
2006 Junior Faculty Award
2003 Showell-Pfizer Award
American Association of Immunologists Inc, Estados Unidos
2002 Showell-Pfizer Award
American Association of Immunologists Inc, Estados Unidos

Título

2017 Fellowship by Published Works
The Royal College of Pathologists, Reino Unido