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Teresa M. Ribeiro-Rodrigues is a PhD candidate and the light microscopy manager in the Microscopy unit at Faculty of Medicine, University of Coimbra. As part of her training, Teresa participated in several courses including: Fundamentals of Widefield and Confocal Microscopy, IMARIS training course for Facility staff, Introduction to data analysis and image processing with MATLAB, Advanced Imaging Methods in Neuroscience, Microscopy data analysis and Advanced fluorescence imaging techniques. Of note, after being awarded with a research grant by FLAD (Fundação Luso-Americana), Teresa spend half year in one of the world's top laboratory in the area of microscopy and intercellular trafficking, the Kirchhausen Lab, at Harvard Medical School, where she had the opportunity to gather theoretical and technical knowledge about state of the art microscopy techniques. Her research focuses on ubiquitin dependent proteostasis and intercellular communication and has resulted in publications in reputable scientific journals, such as the Journal of Cell Science, Cardiovascular Research, FASEB Journal, PLoS Computational Biology, Trends inCell Biology and Scientific Reports. Moreover, Teresa participated, with presentation of her work, in many international congresses including the International Gap Junction Conference and ESC Congress. She is recipient of several grants which allowed her to spend various periods in external labs to deepen her scientific knowledge and technical skills, in reference groups in the area deubiquitinating enzymes and autophagy. In addition to the scientific part, Teresa actively participated in the organization of international congresses and the Electron Microscopy Technical Meeting, held in Coimbra, as well as in the training of Master's students, not only in the monitoring of practical laboratory work, but also in theoretical classes and importantly, as a scientific supervisor of 2 master's students. She has also served as reviewer for several journals such as Sci Rep, MedComm, JCellMolMed., Cells, IJMS, Immuno and Revista Portuguesa de Cardiologia.
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Identificação

Identificação pessoal

Nome completo
Teresa Margarida Ribeiro Rodrigues

Nomes de citação

  • Ribeiro-Rodrigues, Teresa M

Identificadores de autor

Ciência ID
D418-8C9D-E0BC
ORCID iD
0000-0002-5169-6090
Researcher Id
A-1585-2018
Formação
Grau Classificação
2014 - 2020
Em curso
 Envelhecimento e Doenças Crónicas (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade do Minho Escola de Medicina, Portugal
2013
Concluído
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"“Quantitative characterization of vascular formations in vitro and in vivo”" (TESE/DISSERTAÇÃO)
 19 valores
2011
Concluído
 Anatomia Patológica, Citológica e Tanatológica (Licenciatura)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/03 - Atual Assistente de Investigação (carreira) (Investigação) Instituto do Ambiente Tecnologia e Vida, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/02 - 2019/06 Investigador visitante (Investigação) Harvard Medical School, Estados Unidos
2011 - 2013 Estagiário de Investigação (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/04 - 2021 Research Fellow - Project PPBI - Portuguese Platform of BioImaging Universidade de Coimbra Faculdade de Medicina, Portugal
2016/01 - 2016/03 Visiting Student Newcastle University Institute for Cell and Molecular Biosciences, Reino Unido
2015/02 - 2015/04 Visiting Student University of Liverpool Department of Cellular and Molecular Physiology, Reino Unido
Projetos

Projeto

Designação Financiadores
2022/01/01 - 2023/12/31 ConCOEUR: Unveiling the impact of Connexin43 (Cx43)-mediated gene expression at the crossroads of aortic valve stenosis and left ventricle hypertrophy
EXPL/MED-OUT/0590/2021
10.54499/EXPL/MED-OUT/0590/2021
Investigador
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso

Outro

Designação Financiadores
2018/07/26 - 2021/07/25 On the right side: unveiling the mechanisms of pulmonary hypertension reversability and the heart failure progression
PTDC/MEC-CAR/32414/2017
Investigador
Universidade de Coimbra, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/22 - 2021/06/21 A novel mechanism to re-pair Heart Failure with preserved Ejection Fraction (HFpEF) and endothelial damage
PTDC/MED-PAT/32179/2017
Investigador
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Sara F.F. Almeida; Alexandra Fonseca; José Sereno; Hugo R. S. Ferreira; Mariana Lapo-Pais; Tânia Martins-Marques; Teresa M Ribeiro-Rodrigues; et al. "Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis". Small (2022): 2203999-2203999. http://dx.doi.org/10.1002/smll.202203999.
    10.1002/smll.202203999
  2. Amorim M; Martins B; Caramelo F; Gonçalves C; Trindade G; Simão J; Barreto P; et al. "Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis.". Frontiers in medicine (2022): http://europepmc.org/abstract/med/35692536.
    10.3389/fmed.2022.873483
  3. Inês Dinis Aires; Teresa Ribeiro-Rodrigues; Raquel Boia; Magda Ferreira-Rodrigues; Henrique Girão; António Francisco Ambrósio; Ana Raquel Santiago. "Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading". Biomolecules (2021): https://doi.org/10.3390/biom11060770.
    10.3390/biom11060770
  4. Klionsky DJ; Abdel-Aziz AK; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.". Autophagy (2021): http://europepmc.org/abstract/med/33634751.
    10.1080/15548627.2020.1797280
  5. Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; de Jager, Saskia C; Zuzarte, Monica; Ferreira, Cátia; Cruz, Pedro; Reis, Liliana; et al. "Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes". Life Science Alliance 3 12 (2020): e202000821. http://dx.doi.org/10.26508/lsa.202000821.
    10.26508/lsa.202000821
  6. Gaspar LS; Santana MM; Henriques C; Pinto MM; Ribeiro-Rodrigues TM; Girão H; Nobre RJ; Pereira de Almeida L. "Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research.". Molecular therapy. Methods & clinical development (2020): http://europepmc.org/abstract/med/32913880.
    10.1016/j.omtm.2020.07.012
  7. Aires ID; Ribeiro-Rodrigues T; Boia R; Catarino S; Girão H; Ambrósio AF; Santiago AR. "Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.". Glia (2020): http://europepmc.org/abstract/med/32645245.
    10.1002/glia.23880
  8. Pereira, Patricia M. R.; Parada, Belmiro; Ribeiro-Rodrigues, Teresa M.; Fontes-Ribeiro, Carlos A.; Girão, Henrique; Tome, Joao P. C.; Fernandes, Rosa. "Caveolin-1 modulation increases efficacy of a galacto-conjugated phthalocyanine in bladder cancer cells resistant to photodynamic therapy". Molecular Pharmaceutics (2020): http://dx.doi.org/10.1021/acs.molpharmaceut.0c00298.
    Aceite para publicação • 10.1021/acs.molpharmaceut.0c00298
  9. Catarino, Steve; Ribeiro-Rodrigues, Teresa M; Sá Ferreira, Rita; Ramalho, José; Abert, Christine; Martens, Sascha; Girão, Henrique. "A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins". Cells 9 4 (2020): 902. http://dx.doi.org/10.3390/cells9040902.
    10.3390/cells9040902
  10. Batista-Almeida, Daniela; Ribeiro-Rodrigues, Teresa; Martins-Marques, Tânia; Cortes, Luisa; Antunes, Manuel J.; Antunes, Pedro E.; Gonçalves, Lino; et al. "Ischaemia impacts TNT-mediated communication between cardiac cells". Current Research in Cell Biology 1 (2020): 100001. http://dx.doi.org/10.1016/j.crcbio.2020.04.001.
    10.1016/j.crcbio.2020.04.001
  11. Ferreira, Joao Vasco; Rosa Soares, Ana; Ramalho, José S.; Ribeiro-Rodrigues, Teresa; Máximo, Catarina; Zuzarte, Mónica; Girão, Henrique; Pereira, Paulo. "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis". PLOS ONE 14 10 (2019): e0223790. http://dx.doi.org/10.1371/journal.pone.0223790.
    10.1371/journal.pone.0223790
  12. Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Batista-Almeida, Daniela; Aasen, Trond; Kwak, Brenda R.; Girao, Henrique. "Biological Functions of Connexin43 Beyond Intercellular Communication". Trends in Cell Biology 29 10 (2019): 835-847. http://dx.doi.org/10.1016/j.tcb.2019.07.001.
    10.1016/j.tcb.2019.07.001
  13. Almeida Paiva R; Martins-Marques T; Jesus K; Ribeiro-Rodrigues T; Zuzarte M; Silva A; Reis L; et al. "Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation.". Journal of cellular and molecular medicine (2018): http://europepmc.org/abstract/med/30516028.
    10.1111/jcmm.14014
  14. Delgado-Silva J; Fernandes R; Pita IR; Pereira FC; Jaguszewski M; Gutiérrez-Chico JL; Ribeiro-Rodrigues T; et al. "Intravascular imaging, histopathological analysis, and catecholamine quantification following catheter-based renal denervation in a swine model: the impact of prebifurcation energy delivery.". Hypertension research : official journal of the Japanese Society of Hypertension (2018): http://europepmc.org/abstract/med/30006641.
    10.1038/s41440-018-0072-y
  15. Ribeiro-Rodrigues, Teresa M.; Martins-Marques, Tânia; Morel, Sandrine; Kwak, Brenda R.; Girão, Henrique. "Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes". Journal of Cell Science 130 21 (2017): 3619-3630. http://dx.doi.org/10.1242/jcs.200667.
    10.1242/jcs.200667
  16. Ribeiro-Rodrigues, Teresa M.; Laundos, Tiago L.; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P.; et al. "Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis". Cardiovascular Research 113 11 (2017): 1338-1350. http://dx.doi.org/10.1093/cvr/cvx118.
    10.1093/cvr/cvx118
  17. Melo, Tânia; Domingues, Pedro; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Segundo, Marcela A.; Domingues, M. Rosário M.. "Characterization of phospholipid nitroxidation by LC-MS in biomimetic models and in H9c2 Myoblast using a lipidomic approach". Free Radical Biology and Medicine 106 (2017): 219-227. http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.033.
    10.1016/j.freeradbiomed.2017.02.033
  18. Da Silva-Ferrada, Elisa; Ribeiro-Rodrigues, Teresa M.; Rodríguez, Manuel S.; Girão, Henrique. "Proteostasis and SUMO in the heart". The International Journal of Biochemistry & Cell Biology 79 (2016): 443-450. http://dx.doi.org/10.1016/j.biocel.2016.09.015.
    10.1016/j.biocel.2016.09.015
  19. Sousa, Bebiana; Melo, Tânia; Campos, Ana; Moreira, Ana S.P.; Maciel, Elisabete; Domingues, Pedro; Carvalho, Rita Pereira; et al. "Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia". Journal of Cellular Physiology 231 10 (2016): 2266-2274. http://dx.doi.org/10.1002/jcp.25344.
    10.1002/jcp.25344
  20. Soares, Ana Rosa; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Ferreira, Joao Vasco; Catarino, Steve; Pinho, Maria João; Zuzarte, Monica; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13243.
    10.1038/srep13243
  21. Santos-Oliveira, Patrícia; Correia, António; Rodrigues, Tiago; Ribeiro-Rodrigues, Teresa M; Matafome, Paulo; Rodríguez-Manzaneque, Juan Carlos; Seiça, Raquel; Girão, Henrique; Travasso, Rui D. M.. "The Force at the Tip - Modelling Tension and Proliferation in Sprouting Angiogenesis". PLOS Computational Biology 11 8 (2015): e1004436. http://dx.doi.org/10.1371/journal.pcbi.1004436.
    10.1371/journal.pcbi.1004436
  22. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Pinho, Maria J.; Pereira, Paulo; Girao, Henrique. "Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive". Biochemical Society Transactions 43 3 (2015): 471-475. http://dx.doi.org/10.1042/bst20150036.
    10.1042/bst20150036
  23. Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Matafome, Paulo; Ribeiro-Rodrigues, Teresa; Baptista, Rui; Pereira, Paulo; Girão, Henrique. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://dx.doi.org/10.1016/j.biochi.2015.02.020.
    10.1016/j.biochi.2015.02.020
  24. Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Pereira, Paulo; Codogno, Patrice; Girao, Henrique. "Autophagy and Ubiquitination in Cardiovascular Diseases". DNA and Cell Biology 34 4 (2015): 243-251. http://dx.doi.org/10.1089/dna.2014.2765.
    10.1089/dna.2014.2765
  25. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Marques, Carla; Ferreira, João V.; Martins-Marques, Tânia; Pereira, Paulo; Girão, Henrique. "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions". The FASEB Journal 28 11 (2014): 4629-4641. http://dx.doi.org/10.1096/fj.13-248963.
    10.1096/fj.13-248963
Capítulo de livro
  1. Teresa M Ribeiro-Rodrigues; George Kelly; Viktor I. Korolchuk; Henrique Girao. "Intercellular communication and aging". 257-274. Elsevier, 2023.
    10.1016/b978-0-12-823761-8.00005-7
  2. Batista-Almeida, Daniela; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Girao, Henrique. "The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication". In Advances in Experimental Medicine and Biology, 279-302. Springer International Publishing, 2020.
    Publicado • 10.1007/978-3-030-38266-7_12
  3. Martins-Marques, Tania; Anjo, Sandra I.; Ribeiro-Rodrigues, Teresa; Manadas, Bruno; Girao, Henrique. "Targeted Approach for Proteomic Analysis of a Hidden Membrane Protein". In Methods in Molecular Biology, 151-172. Springer New York, 2017.
    10.1007/978-1-4939-7057-5_12
  4. Quinas-Guerra, M. M.; Ribeiro-Rodrigues, T. M.; Rodríguez-Manzaneque, Juan Carlos; Travasso, Rui D. M.. "Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach". In Systems Biology in Cancer Research and Drug Discovery, 197-227. Springer Netherlands, 2012.
    Publicado • 10.1007/978-94-007-4819-4_8
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017 - 2018 Stents, statins and sirolimus: a new approach to prevent restenosis
Coorientador
 Medicina (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014 - 2015 Exosomes release by cardiomyocytes modulate angiogenic response in heart ischemia
Coorientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
Distinções

Prémio

2022 Emerging Star Award
International Gap Junction Conference , Espanha
2019 Research Internship Grant_FLAD
Fundação Luso-Americana, Portugal
2013 Young Investigators Award - Basic Science
Société Européenne de Cardiologie, França

Outra distinção

2016 Short-Term Scientific Mission Grant
European Cooperation in Science and Technology, Bélgica
2015 Short-Term Scientific Mission Grant
European Cooperation in Science and Technology, Bélgica
2014 Boehringer Ingelheim Fonds Travel Grant
Boehringer Ingelheim International GmbH, Alemanha

European Molecular Biology Laboratory, Alemanha
2014 Travel Grant
tebu-bio SAS, França