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Identificação

Identificação pessoal

Nome completo
Ana Dopazo

Nomes de citação

  • Dopazo, Ana

Identificadores de autor

Ciência ID
D617-AEFA-DB6D
ORCID iD
0000-0002-4910-1684

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Métodos de Investigação Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Espanhol; Castelhano Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
1989
Concluído
 n/a (Doktor (PhD))
Consejo Superior de Investigaciones Científicas, Espanha
"Papel de los productos de ftsQ y ftsA de Escherichia coli en la septación" (TESE/DISSERTAÇÃO)
 n/a
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2004/11/01 - Atual Investigador principal (carreira) (Investigação) Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Espanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2001/12/01 - 2004/11/30 Head of the Genomic Analysis Unit Centro Nacional de Investigaciones Oncológicas, Espanha
1999/12/01 - 2001/11/30 Group leader Switch Biotech AG, Alemanha
1997/01/01 - 1999/11/30 Postdoctoral fellow Consejo Superior de Investigaciones Científicas, Espanha
1994/12/01 - 1996/12/31 Postdoctoral fellow Consejo Superior de Investigaciones Científicas, Espanha
1990/01/01 - 1994/11/30 Postdoctoral Fellow, Molecular Neurobiology Lab leaded by professor J. G. Sutcliffe. The Scripps Research Institute, La Jolla, California. Scripps Research Institute, Estados Unidos
1985/12/01 - 1989/12/31 PhD Consejo Superior de Investigaciones Científicas, Espanha
1988/08/01 - 1988/12/31 Exchange visitor. Molecular Biology DepartmentUniversity of Edinburgh. Scotland. The University of Edinburgh, Reino Unido
1984/12/01 - 1985/11/30 MSc Universidad Complutense de Madrid, Espanha
1979/02/03 - 1984/11/30 BS Universidad Complutense de Madrid, Espanha
Produções

Publicações

Artigo em revista
  1. Dopazo, Ana. "Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells". Sci Adv . 7 6 (2021): 9965. https://advances.sciencemag.org/content/7/6/eabb9965.
    Publicado
  2. Dopazo, Ana. "Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease.". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13010077.
    10.3390/pharmaceutics13010077
  3. Dopazo, Ana. "Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance.". Cancers (2020): https://europepmc.org/articles/PMC7763856.
    10.3390/cancers12123689
  4. Dopazo, Ana. "Co-option of Neutrophil Fates by Tissue Environments.". Cell 183 5 (2020): 1282-1297. https://www.cell.com/cell/fulltext/S0092-8674(20)31309-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286742031309X%3Fshowall%3Dtrue.
    Publicado
  5. Dopazo, Ana. "Identification of a peripheral blood gene signature predicting aortic valve calcification.". Physiological genomics (2020): https://doi.org/10.1152/physiolgenomics.00034.2020.
    10.1152/physiolgenomics.00034.2020
  6. Spas Dimitrov-Markov; Javier Perales-Patón; Bruno Bockorny; Ana Dopazo; Manuel Muñoz; Natalia Baños; Victoria Bonilla; et al. "Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single-cell Transcriptomics Analysis of Circulating Tumor Cells". Molecular Cancer Therapeutics 19 8 (2020): 1751-1760. https://doi.org/10.1158/1535-7163.MCT-19-1166.
    10.1158/1535-7163.MCT-19-1166
  7. Dopazo, Ana. "Discovery of new targets to control metastasis in pancreatic cancer by single cell transcriptomics analysis of circulating tumor cells.". Molecular cancer therapeutics (2020): https://doi.org/10.1158/1535-7163.MCT-19-1166.
    10.1158/1535-7163.mct-19-1166
  8. Dopazo, Ana. "oxLDL Receptor in Lymphocytes Prevents Atherosclerosis and Predicts Subclinical Disease". Circulation 139 2 (2019): 243-255. https://www.ncbi.nlm.nih.gov/pubmed/30586697.
    10.1161/circulationaha.118.034326
  9. Dopazo, Ana. "In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer". Nat Commun 9 1 (2018): 3501-3501. https://www.ncbi.nlm.nih.gov/pubmed/30158526.
    10.1038/s41467-018-05742-z
  10. Dopazo, Ana. "5-gene differential expression predicts stability of human intestinal allografts.". Experimental and molecular pathology (2017): http://europepmc.org/abstract/med/28843648.
    10.1016/j.yexmp.2017.08.008
  11. Hill R; Madureira PA; Ferreira B; Baptista I; Machado S; Colaço L; Dos Santos M; et al. "TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT.". (2017): http://europepmc.org/abstract/med/28276427.
    10.1038/ncomms14687
  12. Ribalta J; Alipour A; Sánchez-Cabo F; Vallvé JC; Njo T; Álvarez R; Janssen H; et al. "Differential leucocyte RNA expression in the coronary arteries compared to systemic circulation discriminates between patients with and those without coronary artery disease.". (2017): http://europepmc.org/abstract/med/28188023.
  13. Dopazo, Ana. "AG-NGS: A powerful and user-friendly computing application for the semi-automated preparation of next-generation sequencing libraries using open liquid handling platforms". Biotechniques 62 1 (2017): xvi-xvi. https://dx.doi.org/10.2144/000114504.
    10.2144/000114504
  14. Dopazo, Ana. "DNA Methylation of miR-7 is a Mechanism Involved in Platinum Response through MAFG Overexpression in Cancer Cells". Theranostics 7 17 (2017): 4118-4134. https://www.ncbi.nlm.nih.gov/pubmed/29158814.
    10.7150/thno.20112
  15. Municio C; Soler Palacios B; Estrada-Capetillo L; Benguria A; Dopazo A; García-Lorenzo E; Fernández-Arroyo S; et al. "Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis.". (2016): http://europepmc.org/abstract/med/26920997.
    10.1136/annrheumdis-2015-208736
  16. Blanco FJ; Ojeda-Fernandez L; Aristorena M; Gallardo-Vara E; Benguria A; Dopazo A; Langa C; Botella LM; Bernabeu C. "Genome-wide transcriptional and functional analysis of endoglin isoforms in the human promonocytic cell line U937.". (2015): http://europepmc.org/abstract/med/25216259.
    10.1002/jcp.24827
  17. Callejas S; Álvarez R; Benguria A; Dopazo A. "AG-NGS: a powerful and user-friendly computing application for the semi-automated preparation of next-generation sequencing libraries using open liquid handling platforms.". (2014): http://europepmc.org/abstract/med/24447136.
    10.2144/000114124
  18. Hill R; Kalathur RK; Callejas S; Colaço L; Brandão R; Serelde B; Cebriá A; et al. "A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.". (2014): http://europepmc.org/abstract/med/25488803.
    10.1186/s13058-014-0482-y
  19. Trigueros-Motos L; González-Granado JM; Cheung C; Fernández P; Sánchez-Cabo F; Dopazo A; Sinha S; Andrés V. "Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-¿B activity.". (2013): http://europepmc.org/abstract/med/23448971.
    10.1161/atvbaha.112.300539
  20. Aguilera-Montilla N; Chamorro S; Nieto C; Sánchez-Cabo F; Dopazo A; Fernández-Salguero PM; Rodríguez-Fernández JL; et al. "Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells.". (2013): http://europepmc.org/abstract/med/23430108.
    10.1182/blood-2012-07-445106
  21. Bhardwaj D; Náger M; Camats J; David M; Benguria A; Dopazo A; Cantí C; Herreros J. "Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/ß-catenin signaling.". (2013): http://europepmc.org/abstract/med/23641195.
    10.3389/fncel.2013.00052
  22. Menezes J; Makishima H; Gomez I; Acquadro F; Gómez-López G; Graña O; Dopazo A; et al. "CSF3R T618I co-occurs with mutations of splicing and epigenetic genes and with a new PIM3 truncated fusion gene in chronic neutrophilic leukemia.". (2013): http://europepmc.org/abstract/med/24212483.
    10.1038/bcj.2013.55
  23. Estrada JC; Torres Y; Benguría A; Dopazo A; Roche E; Carrera-Quintanar L; Pérez RA; et al. "Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy.". (2013): http://europepmc.org/abstract/med/23807220.
    10.1038/cddis.2013.211
  24. López-Lera A; Cabo FS; Garrido S; Dopazo A; López-Trascasa M. "Disease-modifying factors in hereditary angioedema: an RNA expression-based screening.". (2013): http://europepmc.org/abstract/med/23688356.
    10.1186/1750-1172-8-77
  25. Lara-Pezzi E; Dopazo A; Manzanares M. "Understanding cardiovascular disease: a journey through the genome (and what we found there).". (2012): http://europepmc.org/abstract/med/22730474.
    10.1242/dmm.009787
  26. Estrada JC; Albo C; Benguría A; Dopazo A; López-Romero P; Carrera-Quintanar L; Roche E; et al. "Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis.". (2012): http://europepmc.org/abstract/med/22139129.
    10.1038/cdd.2011.172
  27. Kauselmann G; Dopazo A; Link W. "Identification of disease-relevant genes for molecularly-targeted drug discovery.". (2012): http://europepmc.org/abstract/med/22165964.
    10.2174/156800912798888947
  28. Ramos-Cejudo J; Gutiérrez-Fernández M; Rodríguez-Frutos B; Expósito Alcaide M; Sánchez-Cabo F; Dopazo A; Díez-Tejedor E. "Spatial and temporal gene expression differences in core and periinfarct areas in experimental stroke: a microarray analysis.". (2012): http://europepmc.org/abstract/med/23284893.
    10.1371/journal.pone.0052121
  29. Villar D; Ortiz-Barahona A; Gómez-Maldonado L; Pescador N; Sánchez-Cabo F; Hackl H; Rodriguez BA; et al. "Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions.". (2012): http://europepmc.org/abstract/med/23029193.
    10.1371/journal.pone.0045708
  30. Martín Y; Dopazo A; Hernández-Chico C. "Progress and challenges in developing a molecular diagnostic test for neurofibromatosis type 1.". (2011): http://europepmc.org/abstract/med/21902526.
    10.1586/erm.11.52
  31. Sánchez-Ramos C; Tierrez A; Fabregat-Andrés O; Wild B; Sánchez-Cabo F; Arduini A; Dopazo A; Monsalve M. "PGC-1a regulates translocated in liposarcoma activity: role in oxidative stress gene expression.". (2011): http://europepmc.org/abstract/med/21338289.
    10.1089/ars.2010.3643
  32. Tomé M; López-Romero P; Albo C; Sepúlveda JC; Fernández-Gutiérrez B; Dopazo A; Bernad A; González MA. "miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells.". (2011): http://europepmc.org/abstract/med/21164520.
    10.1038/cdd.2010.167
  33. Salgado M; López-Romero P; Callejas S; López M; Labarga P; Dopazo A; Soriano V; Rodés B. "Characterization of host genetic expression patterns in HIV-infected individuals with divergent disease progression.". (2011): http://europepmc.org/abstract/med/21239032.
    10.1016/j.virol.2010.12.037
  34. Callejas S; Alvarez R; Dopazo A. "Automatic genomics: a user-friendly program for the automatic designing and plate loading of medium-throughput qPCR experiments.". (2011): http://europepmc.org/abstract/med/21231922.
    10.2144/000113574
  35. Simon-Areces J; Dopazo A; Dettenhofer M; Rodriguez-Tebar A; Garcia-Segura LM; Arevalo MA. "Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons.". (2011): http://europepmc.org/abstract/med/21818269.
    10.1371/journal.pone.0021825
  36. Vivas Y; Martínez-García C; Izquierdo A; Garcia-Garcia F; Callejas S; Velasco I; Campbell M; et al. "Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass.". (2011): http://europepmc.org/abstract/med/22208362.
    10.1186/1755-8794-4-86
  37. Sánchez-Cabo F; Rainer J; Dopazo A; Trajanoski Z; Hackl H. "Insights into global mechanisms and disease by gene expression profiling.". (2011): http://europepmc.org/abstract/med/21370089.
    10.1007/978-1-61779-027-0_13
  38. Lamas JR; Rodríguez-Rodríguez L; Vigo AG; Alvarez-Lafuente R; López-Romero P; Marco F; Camafeita E; et al. "Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis.". (2010): http://europepmc.org/abstract/med/20498197.
    10.1136/ard.2009.122564
  39. López-Huertas MR; Callejas S; Abia D; Mateos E; Dopazo A; Alcamí J; Coiras M. "Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon.". (2010): http://europepmc.org/abstract/med/20139419.
    10.1093/nar/gkq037
  40. Zanella F; Renner O; García B; Callejas S; Dopazo A; Peregrina S; Carnero A; Link W. "Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells.". (2010): http://europepmc.org/abstract/med/20208562.
    10.1038/onc.2010.58
  41. Puig-Kröger A; Aguilera-Montilla N; Martínez-Nuñez R; Domínguez-Soto A; Sánchez-Cabo F; Martín-Gayo E; Zaballos A; et al. "The novel RUNX3/p33 isoform is induced upon monocyte-derived dendritic cell maturation and downregulates IL-8 expression.". (2010): http://europepmc.org/abstract/med/20615577.
    10.1016/j.imbio.2010.05.018
  42. López-Romero P; González MA; Callejas S; Dopazo A; Irizarry RA. "Processing of Agilent microRNA array data.". (2010): http://europepmc.org/abstract/med/20205787.
    10.1186/1756-0500-3-18
  43. López-Huertas MR; Callejas S; Abia D; Dopazo A; Alcamí J; Coiras M. "Modifications in host cell structure and functions mediated by Tat intracellular expression are greatly dependent on the second exon.". (2009): http://europepmc.org/abstract/PMC/PMC2766990.
  44. Varea O; Garrido JJ; Dopazo A; Mendez P; Garcia-Segura LM; Wandosell F. "Estradiol activates beta-catenin dependent transcription in neurons.". (2009): http://europepmc.org/abstract/med/19360103.
    10.1371/journal.pone.0005153
  45. Konstantinidou V; Khymenets O; Fito M; De La Torre R; Anglada R; Dopazo A; Covas MI. "Characterization of human gene expression changes after olive oil ingestion: an exploratory approach.". (2009): http://europepmc.org/abstract/med/19545487.
  46. Gamundi MJ; Hernan I; Muntanyola M; Maseras M; López-Romero P; Alvarez R; Dopazo A; Borrego S; Carballo M. "Transcriptional expression of cis-acting and trans-acting splicing mutations cause autosomal dominant retinitis pigmentosa.". (2008): http://europepmc.org/abstract/med/18412284.
    10.1002/humu.20747
  47. Diez D; Alvarez R; Dopazo A. "Codelink: an R package for analysis of GE healthcare gene expression bioarrays.". (2007): http://europepmc.org/abstract/med/17344240.
    10.1093/bioinformatics/btm072
  48. Brú A; del Fresno C; Soares-Schanoski A; Albertos S; Brú I; Porres A; Rollán-Landeras E; et al. "Position-dependent expression of GADD45alpha in rat brain tumours.". (2007): http://europepmc.org/abstract/med/17917095.
    10.1007/s12032-007-0025-9
  49. Martínez J; Gutiérrez A; Casas J; Lladó V; López-Bellan A; Besalduch J; Dopazo A; Escribá PV. "The repression of E2F-1 is critical for the activity of Minerval against cancer.". (2005): http://europepmc.org/abstract/med/16027227.
    10.1124/jpet.105.088716
  50. Meléndez B; Díaz-Uriarte R; Cuadros M; Martínez-Ramírez A; Fernández-Piqueras J; Dopazo A; Cigudosa JC; et al. "Gene expression analysis of chromosomal regions with gain or loss of genetic material detected by comparative genomic hybridization.". (2004): http://europepmc.org/abstract/med/15382261.
    10.1002/gcc.20105
  51. Martínez N; Camacho FI; Algara P; Rodríguez A; Dopazo A; Ruíz-Ballesteros E; Martín P; et al. "The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival.". (2003): http://europepmc.org/abstract/med/14678979.
  52. Jimenez AI; Fernandez P; Dominguez O; Dopazo A; Sanchez-Cespedes M. "Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway.". (2003): http://europepmc.org/abstract/med/12649203.
  53. Tracey L; Villuendas R; Ortiz P; Dopazo A; Spiteri I; Lombardia L; Rodríguez-Peralto JL; et al. "Identification of genes involved in resistance to interferon-alpha in cutaneous T-cell lymphoma.". (2002): http://europepmc.org/abstract/med/12414529.
    10.1016/s0002-9440(10)64459-8
  54. Gautvik KM; de Lecea L; Gautvik VT; Danielson PE; Tranque P; Dopazo A; Bloom FE; Sutcliffe JG. "Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction.". (1996): http://europepmc.org/abstract/med/8710940.
    10.1073/pnas.93.16.8733
  55. Usui H; Falk JD; Dopazo A; de Lecea L; Erlander MG; Sutcliffe JG. "Isolation of clones of rat striatum-specific mRNAs by directional tag PCR subtraction.". (1994): http://europepmc.org/abstract/med/8046460.
  56. Sánchez M; Dopazo A; Pla J; Robinson AC; Vicente M. "Characterisation of mutant alleles of the cell division protein FtsA, a regulator and structural component of the Escherichia coli septator.". (1994): http://europepmc.org/abstract/med/7748929.
    10.1016/0300-9084(94)90032-9
  57. Dopazo A; Lovenberg TW; Danielson PE; Ottiger HP; Sutcliffe JG. "Primary structure of mouse secretogranin III and its absence from deficient mice.". (1993): http://europepmc.org/abstract/med/7917832.
    10.1007/bf02821554
  58. Dopazo A; Palacios P; Sánchez M; Pla J; Vicente M. "An amino-proximal domain required for the localization of FtsQ in the cytoplasmic membrane, and for its biological function in Escherichia coli.". (1992): http://europepmc.org/abstract/med/1574000.
    10.1111/j.1365-2958.1992.tb01520.x
  59. Vicente M; Palacios P; Dopazo A; Garrido T; Pla J; Aldea M. "On the chronology and topography of bacterial cell division.". (1991): http://europepmc.org/abstract/med/1925025.
    10.1016/0923-2508(91)90038-c
  60. Pla J; Dopazo A; Vicente M. "The native form of FtsA, a septal protein of Escherichia coli, is located in the cytoplasmic membrane.". (1990): http://europepmc.org/abstract/med/2203741.
  61. Dopazo A; Tormo A; Aldea M; Vicente M. "Structural inhibition and reactivation of Escherichia coli septation by elements of the SOS and TER pathways.". (1987): http://europepmc.org/abstract/med/3031022.
  62. Tormo A; Dopazo A; de la Campa AG; Aldea M; Vicente M. "Coupling between DNA replication and cell division mediated by the FtsA protein in Escherichia coli: a pathway independent of the SOS response, the "TER" pathway.". (1985): http://europepmc.org/abstract/med/2414272.