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Valdemar Máximo (VM) graduated in Biology in 1994 in Coimbra University where he continued as a Master student, in 1995/1996 studying the role of mitochondrial dysfunction in schizophrenia. VM did his PhD in 2001 at the Faculty of Medicine of the University of Porto (FMUP) in a project developed at Ipatimup and Ludwig-Maximilians-University Munich, aiming to evaluate the role of mitochondrial dysfunction in thyroid tumours, particularly in Hürthle cell tumours. Due to his expertise in mitochondria, VM introduced at Ipatimup the interest on the role played by mitochondrial abnormalities in cancer. As a Post-doc he continued focusing his research on this topic, clarifying the role mtDNA abnormalities and metabolism in tumour development leading to his recognition as an international reference scientist in the field. In 2007, VM was hired as a Ciência 2007 researcher at Ipatimup and since then he built a research team focusing on one of the hottest areas of cancer research ¿ cancer metabolism. VM has supervised 13 MSc and 6 PhD students as well as Post-docs. Presently, VM is a PI of a team studying ¿ Cancer as a metabolic disease and Associate Professor of Biopathology and Mitochondrial Diseases at the FMUP. He has published 88 peer-reviewed papers, with over 4784 citations by other authors and with an h-index of 33. VM led and is/was member of the team of several FCT-funded projects and of international projects in collaboration with CELAC countries, namely with Brazil, in collaboration with Doctor Laura Ward, through a Brazilian Government - the National Council for Scientific and Technological Development of the Ministry of Science, Technology and Innovation (CNPq/MCTI) - Special Visiting Researcher grant.
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Identificação

Identificação pessoal

Nome completo
Valdemar de Jesus Conde Máximo

Nomes de citação

  • Máximo, Valdemar
  • Máximo, V

Identificadores de autor

Ciência ID
D811-0BE4-09D7
ORCID iD
0000-0002-8631-8356

Domínios de atuação

  • Ciências Médicas e da Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Patologia
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana
  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador independente (B1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2001
Concluído
 Ph.D. in human biology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"MITOCHONDRIAL DNA ABNORMALITIES (POINT MUTATIONS AND LARGE DELETIONS) IN ONCOBIOLOGY: A STUDY WITH EMPHASIS IN HÜRTHLE CELL TUMOURS OF THE HUMAN THYROID" (TESE/DISSERTAÇÃO)
 Approved unanimously
1994
Concluído
 Biology (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Evaluation of Sister Chromatid Exchange in Bloom's syndrome" (TESE/DISSERTAÇÃO)
 16/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/10/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013/01/01 - Atual Investigador (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/08/01 - Atual Professor Associado (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2019 Professor Auxiliar (Docente Universitário) Universidade do Porto, Portugal
2014 - 2016 Professor Auxiliar (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2014 Professor Associado (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/01/01 - 2014/05/08 Invited Associate Professor Universidade do Porto Faculdade de Medicina, Portugal
2008/01/01 - 2012/12/01 Researcher - Programa Ciência 2007 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2001/11/02 - 2006/12/31 Post-Doc Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1997/02/01 - 2001/11/01 PhD student Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projetos

Bolsa

Designação Financiadores
2005/09 - 2006/08 Inactivation of mitochondrial complex II tumor suppressor genes in sporadic and familiar paragangliomas and pheochromocytomas
61945
Provided by PTCRIS: 61945
POCI/SAU-OBS/61945/2004
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2025/02/01 - Atual Decode metastatic thyroid cancer
SPEDM - 2024
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo
Em avaliação
2025/01/01 - Atual Dissecting cellular heterogeneity in cancer: single-cell proteogenomic characterization of aggressive thyroid cancers
COMPETE2030-FEDER-00682100
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em avaliação
2024/01/01 - Atual The metastatic code of thyroid cancer
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Em curso
2020/01 - Atual Instituto de Investigação e Inovação em Saúde
UIDB/04293/2020
Investigador
Fundação para a Ciência e a Tecnologia
2023/03/01 - 2024/08/31 Unravel familial non-medullary thyroid cancer aetiology: A Genetic Orphan Disease.
2022.05763.PTDC
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07 - 2021/07 The other faces of Telomerase: Looking beyond tumor immortalization (co-PI)
PTDC/MED-ONC/31438/2017
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2018/07 - 2021/06 A novel post-transcriptional regulatory network controlling intestinal stem cells fate
PTDC/BIA-MOL/31538/2017
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2016/12 - 2020/11 NEw Targets in DIAstolic heart failure: from coMOrbidities to persoNalizeD medicine
SAICTPAC/0047/2015
Investigador
Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/07/02 - 2019/11/26 "ROle of the MITOchondrial fission protein Drp1 as a prognosis and predictive biomarker in the treatment of differentiated thyroid cancer (ROMITO-DRP1)"
ROMITO-DRP1
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Em curso
2013/07/01 - 2015 Combining siRNA and AAV therapy approaches to target human basal-like breast cancer: from vector development to anti-tumor efficacy evaluation.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/126222/PT
PTDC/BBB-BIO/1240/2012
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012 - 2015 Mapping of genes predisposing to familial thyroid tumours
info:eu-repo/grantAgreement/FCT/5646-ICCMS/83037/PT
PIC/IC/83037/2007
Investigador responsável
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2014 GRIM-19, a novel protein involved in cell apoptosis: structure-function characterization
PTDC/BIA-PRO/113064/2009
Investigador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

ESRF, França
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009/01/01 - 2012/06/30 Cancer risk and irradiation: an epidemiological and genetic study of a cohort irradiated for Tinea capitis
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/83154/PT
Provided by PTCRIS: 83154
83154
PIC/IC/83154/2007
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia

Fundação para a Ciência e a Tecnologia
Concluído
2006 - 2008 Mapping of genes predisposing to familial thyroid tumours
N.A.
Investigador responsável
Concluído
2005 - 2007 In vitro studies of compounds with putative anti-oxidant activity, obtained from medicinal plants traditionally used in Portugal
N.A.
Investigador responsável
Concluído
2002/09/01 - 2005 Mitochondrial DNA (mtDNA) mutations and deletions in thyroid Hürthle cell tumours: Characterisation, prognosis and association with mtDNA polymorphisms.
info:eu-repo/grantAgreement/FCT/POCI/41055/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2002/01/01 - 2005 Mitochondrial DNA deletions and mutations in post Chernobyl thyroid tumours and in the respective normal thyroid parenchyma.
info:eu-repo/grantAgreement/FCT/POCI/43944/PT
POCTI/CBO/47477/2002
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2001/01/01 - 2002 Mitochondrial DNA deletions and mutations in post Chernobyl thyroid tumours and in the respective normal thyroid parenchyma.
POCTI/CBO/43944/2001
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Chantre, Ana; Correia, Marcelo; Soares, Paula; Máximo, Valdemar; Lima, Raquel T.. "Targeting mitochondrial TERT to overcome therapeutic resistance". 2023.
Artigo em revista
  1. Elisabete Teixeira; Cláudia Fernandes; Maria Bungardean; Arnaud Da Cruz Paula; Raquel T. Lima; Rui Batista; João Vinagre; et al. "Investigating USP42 Mutation as Underlying Cause of Familial Non-Medullary Thyroid Carcinoma". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25031522.
    10.3390/ijms25031522
  2. Canberk, S.; Gonçalves, J.; Rios, E.; Povoa, A.A.; Tastekin, E.; Sobrinho-Simões, M.; Uguz, A.; et al. "The Role of 5-Hydroxymethylcytosine as a Potential Epigenetic Biomarker in a Large Series of Thyroid Neoplasms". Endocrine Pathology (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85183365237&partnerID=MN8TOARS.
    Submetido • 10.1007/s12022-024-09800-9
  3. Máximo, V.; Melo, M.; Zhu, Y.; Gazzo, A.; Sobrinho Simões, M.; Da Cruz Paula, A.; Soares, P.. "Genomic profiling of primary and metastatic thyroid cancers". Endocrine-related cancer 31 2 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85182501436&partnerID=MN8TOARS.
    10.1530/ERC-23-0144
  4. Máximo, V.; Melo, M.; Sobrinho-Simões, M.; Soares, P.; Da Cruz Paula, A.. "Genomic profiling of lymph node and distant metastases from papillary and poorly differentiated thyroid carcinomas". Endocrine (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85198971426&partnerID=MN8TOARS.
    10.1007/s12020-024-03968-0
  5. Rabi, L.T.; Peres, K.C.; Nascimento, M.; de Souza Teixeira, E.; de Freitas, L.L.L.; Barreto, I.S.; Geraldo, M.V.; et al. "Investigation of the clinical utility of adhesion molecules in the management of thyroid nodules". Scientific Reports 13 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85149954148&partnerID=MN8TOARS.
    10.1038/s41598-023-31302-7
  6. Mafalda Santos; Marta Ferreira; Patrícia Oliveira; Nuno Mendes; Ana André; André F. Vieira; Joana B. Nunes; et al. "Epithelial-Mesenchymal Plasticity Induced by Discontinuous Exposure to TGFß1 Promotes Tumour Growth". Biology (2022): https://www.mdpi.com/2079-7737/11/7/1046.
    10.3390/biology11071046
  7. Sule Canberk; Helena Barroca; Inês Girão; Ozlem Aydin; Aysun Uguz; Kivilcim Erdogan; Ebru Tastekin; et al. "Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis". Diagnostics (2022): https://doi.org/10.3390/diagnostics12010179.
    10.3390/diagnostics12010179
  8. Sule Canberk; Marcelo Correia; Ana Rita Lima; Massimo Bongiovanni; Manuel Sobrinho-Simões; Paula Soares; Valdemar Máximo. "The Multifaceted Profile of Thyroid Disease in the Background of DICER1 Germline and Somatic Mutations: Then, Now and Future Perspectives". Journal of Molecular Pathology (2022): https://doi.org/10.3390/jmp3010001.
    10.3390/jmp3010001
  9. Dal’ Bó, I.F.; Teixeira, E.S.; Rabi, L.T.; Peres, K.C.; Nascimento, M.; Chiamolera, M.I.; Máximo, V.; Bufalo, N.E.; Ward, L.S.. "Alternation between toxic and proliferative effects of Roundup® on human thyroid cells at different concentrations". Frontiers in Endocrinology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85136199576&partnerID=MN8TOARS.
    10.3389/fendo.2022.904437
  10. Canberk, Sule; Barroca, Helena; Girão, Inês; Aydin, Ozlem; Uguz, Aysun; Erdogan, Kivilcim; Tastekin, Ebru; et al. "Performance of the Bethesda system for reporting thyroid cytology in multi-institutional large cohort of pediatric thyroid nodules: a detailed analysis". (2022): http://hdl.handle.net/10400.1/17534.
    10.3390/diagnostics12010179
  11. Correia, Marcelo; Lima, Ana Rita; Batista, Rui; Máximo, Valdemar; Sobrinho-Simões, Manuel. "Inherited Thyroid Tumors With Oncocytic Change". Frontiers in Endocrinology 12 (2021): http://dx.doi.org/10.3389/fendo.2021.691979.
    10.3389/fendo.2021.691979
  12. Karina Colombera Peres; Larissa Teodoro; Laís Helena Pereira Amaral; Elisângela Souza Teixeira; Icléia Siqueira Barreto; Leandro Luiz Lopes de Freitas; Valdemar Maximo; et al. "Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis". Archives of Endocrinology and Metabolism (2021): https://doi.org/10.20945/2359-3997000000330.
    10.20945/2359-3997000000330
  13. Bruno Cavadas; Marina Leite; Nicole Pedro; Ana C. Magalhães; Joana Melo; Marcelo Correia; Valdemar Máximo; et al. "Shedding Light on the African Enigma: In Vitro Testing of Homo sapiens-Helicobacter pylori Coevolution". Microorganisms (2021): https://doi.org/10.3390/microorganisms9020240.
    10.3390/microorganisms9020240
  14. Hugo Osório; Cátia Silva; Marta Ferreira; Irene Gullo; Valdemar Máximo; Rita Barros; Fernando Mendonça; Carla Oliveira; Fátima Carneiro. "Proteomics Analysis of Gastric Cancer Patients with Diabetes Mellitus". Journal of Clinical Medicine (2021): https://doi.org/10.3390/jcm10030407.
    10.3390/jcm10030407
  15. Soares, P.; Póvoa, A.A.; Melo, M.; Vinagre, J.; Máximo, V.; Eloy, C.; Cameselle-Teijeiro, J.M.; Sobrinho-Simões, M.. "Molecular Pathology of Non-familial Follicular Epithelial–Derived Thyroid Cancer in Adults: From RAS/BRAF-like Tumor Designations to Molecular Risk Stratification". Endocrine Pathology (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85101221931&partnerID=MN8TOARS.
    10.1007/s12022-021-09666-1
  16. Canberk, S.; Lima, A.R.; Pinto, M.; Máximo, V.. "Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens". Frontiers in Medicine 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103796300&partnerID=MN8TOARS.
    10.3389/fmed.2021.640460
  17. Canberk, S.; Lima, A.R.; Pinto, M.; Soares, P.; Máximo, V.. "Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application". Frontiers in Endocrinology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107374480&partnerID=MN8TOARS.
    10.3389/fendo.2021.674666
  18. Isabel Valença; Ana Rita Ferreira; Marcelo Correia; Sandra Kühl; Carlo van Roermund; Hans R. Waterham; Valdemar Máximo; Markus Islinger; Daniela Ribeiro. "Prostate Cancer Proliferation Is Affected by the Subcellular Localization of MCT2 and Accompanied by Significant Peroxisomal Alterations". Cancers (2020): https://doi.org/10.3390/cancers12113152.
    10.3390/cancers12113152
  19. Caroline A. Sieverink; Rui P. M. Batista; Hugo J. M. Prazeres; João Vinagre; Cristina Sampaio; Ricardo R. Leão; Valdemar Máximo; J. Alfred Witjes; Paula Soares. "Clinical Validation of a Urine Test (Uromonitor-V2®) for the Surveillance of Non-Muscle-Invasive Bladder Cancer Patients". Diagnostics 10 10 (2020): 745-745. https://doi.org/10.3390/diagnostics10100745.
    10.3390/diagnostics10100745
  20. Miranda, Silvana; Correia, Marcelo; Dias, Anabela G.; Pestana, Ana; Soares, Paula; Nunes, Joana; Lima, Jorge; Máximo, Valdemar; Boaventura, Paula. "Evaluation of the role of mitochondria in the non-targeted effects of ionizing radiation using cybrid cellular models". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-63011-w.
    Acesso aberto • Publicado • 10.1038/s41598-020-63011-w
  21. Rui Batista; Nuno Vinagre; Sara Meireles; Vinagre, J; Hugo Prazeres; Ricardo Leão; Valdemar Maximo; Paula Soares. "Biomarkers for Bladder Cancer Diagnosis and Surveillance: A Comprehensive Review". Diagnostics (2020): https://www.mdpi.com/2075-4418/10/1/39.
    10.3390/diagnostics10010039
  22. Rui Batista; Luís Lima; Vinagre, J; Vasco Pinto; Joana Lyra; Valdemar Maximo; Lúcio Santos; Paula Soares. "TERT Promoter Mutation as a Potential Predictive Biomarker in BCG-Treated Bladder Cancer Patients". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/3/947.
    10.3390/ijms21030947
  23. Rodrigues-Pereira, P.; Macedo, S.; Gaspar, T.B.; Canberk, S.; Selmi-Ruby, S.; Máximo, V.; Soares, P.; Miranda-Alves, L.. "Relevant dose of the environmental contaminant, tributyltin, promotes histomorphological changes in the thyroid gland of male rats". Molecular and Cellular Endocrinology 502 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076393522&partnerID=MN8TOARS.
    10.1016/j.mce.2019.110677
  24. Pereira, B.; Amaral, A.L.; Dias, A.; Mendes, N.; Muncan, V.; Silva, A.R.; Thibert, C.; et al. "MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium". EMBO Reports (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079420593&partnerID=MN8TOARS.
    10.15252/embr.201948938
  25. Canberk, S.; Ferreira, J.C.; Pereira, L.; Batlsta, R.; Vieira, A.F.; Soares, P.; Sobrinho Simões, M.; Máximo, V.. "Analyzing the Role of DICER1 germline variations in papillary thyroid carcinoma". European Thyroid Journal (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090120707&partnerID=MN8TOARS.
    10.1159/000509183
  26. Lima, A.R.; Correia, M.; Santos, L.; Tavares, C.; Rios, E.; Canberk, S.; Soares, P.; et al. "S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma". Endocrine (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85096404453&partnerID=MN8TOARS.
    10.1007/s12020-020-02546-4
  27. Canberk, S.; Lima, A.R.; Correia, M.; Batista, R.; Soares, P.; Máximo, V.; Simões, M.S.. "Oncocytic thyroid neoplasms: from histology to molecular biology". Diagnostic Histopathology 25 5 (2019): 154-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062901679&partnerID=MN8TOARS.
    10.1016/j.mpdhp.2019.02.002
  28. Cavadas, B.; Pereira, J.B.; Correia, M.; Fernandes, V.; Eloy, C.; Sobrinho-Simões, M.; Soares, P.; et al. "Genomic and transcriptomic characterization of the mitochondrial-rich oncocytic phenotype on a thyroid carcinoma background". Mitochondrion 46 (2019): 123-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045246493&partnerID=MN8TOARS.
    10.1016/j.mito.2018.04.001
  29. Batista, Rui; Vinagre, João; Prazeres, Hugo; Sampaio, Cristina; Peralta, Pedro; Conceição, Paulo; Sismeiro, Amílcar; et al. "Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence Surveillance of Patients With Non-Muscle-Invasive Bladder Cancer in a Comprehensive Multicenter Study". (2019): http://hdl.handle.net/10400.26/31737.
    10.3389/fgene.2019.01237
  30. Donner, L.R.; Maximo, V.. "Oncocytic melanoma: A study of a rare entity". American Journal of Dermatopathology 40 11 (2018): 854-856. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055074847&partnerID=MN8TOARS.
    10.1097/DAD.0000000000001183
  31. Lima, A.R.; Santos, L.; Correia, M.; Soares, P.; Sobrinho-Simões, M.; Melo, M.; Máximo, V.. "Dynamin-related protein 1 at the crossroads of cancer". Genes 9 2 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042408082&partnerID=MN8TOARS.
    10.3390/genes9020115
  32. Pereira, S.S.; Máximo, V.; Coelho, R.; Batista, R.; Soares, P.; Guerreiro, S.G.; Sobrinho-Simões, M.; Monteiro, M.P.; Pignatelli, D.. "Telomerase and N-Cadherin Differential Importance in Adrenocortical Cancers and Adenomas". Journal of Cellular Biochemistry 118 8 (2017): 2064-2071. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018630027&partnerID=MN8TOARS.
    10.1002/jcb.25811
  33. Correia, M.; Pinheiro, P.; Batista, R.; Soares, P.; Sobrinho-Simões, M.; Máximo, V.. "Etiopathogenesis of oncocytomas". Seminars in Cancer Biology 47 (2017): 82-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-85023602451&partnerID=MN8TOARS.
    10.1016/j.semcancer.2017.06.014
  34. Almeida, L.M.C.A.; Silva, R.; Cavadas, B.; Lima, J.; Pereira, L.; Soares, P.; Sobrinho-Simões, M.; Lopes, J.M.; Máximo, V.. "GLUT1, MCT1/4 and CD147 overexpression supports the metabolic reprogramming in papillary renal cell carcinoma". Histology and Histopathology 32 10 (2017): 1029-1040. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021784421&partnerID=MN8TOARS.
    10.14670/HH-11-863
  35. Grácio, Daniela; Magro, Fernando; Raquel T. Lima; Máximo, Valdemar. "An overview on the role of autophagy in cancer therapy". Hematology & Medical Oncology 2 1 (2017): http://dx.doi.org/10.15761/hmo.1000117.
    Publicado • 10.15761/hmo.1000117
  36. Silva, L.S.; Goncalves, L.G.; Silva, F.; Domingues, G.; Maximo, V.; Ferreira, J.; Lam, E.W.-F.; et al. "STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment". Tumor Biology 37 4 (2016): 5385-5395. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946854642&partnerID=MN8TOARS.
    10.1007/s13277-015-4385-z
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  95. Maximo, V.; Sobrinho-Simoes, M.. "Mitochondrial DNA 'common' deletion in Hurthle cell lesions of the thyroid [2] (multiple letters)". Journal of Pathology 192 4 (2000): 561-563. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033673552&partnerID=MN8TOARS.
    10.1002/1096-9896(200012)192:4<561::AID-PATH790>3.0.CO;2-3
  96. Manco, L.; Ribeiro, M.L.; Maximo, V.; Almeida, H.; Costa, A.; Freitas, O.; Barbot, J.; Abade, A.; Tamagnini, G.. "A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency". British Journal of Haematology 110 4 (2000): 993-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033765506&partnerID=MN8TOARS.
    10.1046/j.1365-2141.2000.02283.x
  97. Maximo, V.; Soares, P.; Seruca, R.; Sobrinho-Simoes, M.. "Comments on: Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients, Tamura, et al. Eur J Cancer 1999, 35, 316-319". European Journal of Cancer 35 9 (1999): 1407-1408. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032766997&partnerID=MN8TOARS.
    10.1016/S0959-8049(99)00126-4
  98. Maximo, V.; Sores, P.; Rocha, A.S.; Sobrinho-Simoes, M.. "The common deletion of mitochondrial dna is found in goiters and thyroid tumors with and without oxyphil cell change". Ultrastructural Pathology 22 3 (1998): 271-273. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031719197&partnerID=MN8TOARS.
    10.3109/01913129809033479
Livro
  1. Eloy, C.; Soares, P.; Máximo, V.; Sobrinho-Simões, M.. Thyroid and parathyroid glands. 2017.
    10.1007/978-3-662-49672-5_14
  2. Lima, J.; Máximo, V.; Soares, P.; Portugal, R.; Guimarães, S.; Sobrinho-Simões, M.. Mitochondria and oncocytomas. 2009.
    10.1007/978-0-387-84835-8_11
Poster em conferência
  1. da Cruz Paula, A; Campos, R; Teles Jesus, Tito; Vinagre, J; Máximo, V; Soares, P. "Genomic Characterization of APOBEC-Related Papillary Thyroid Carcinomas". Trabalho apresentado em Congresso Português de Endocrinologia / 76.ª Reunião Anual da SPEDM, 2025.
  2. Batista, Rui; Anacleto, Sara; Vinagre, João; Prazeres, Hugo; Gonçalves, David; Dias, Jorge; Oliveira, Carlos; et al. "A novel urine test for non-muscle invasive bladder cancer recurrence detection - a Portuguese multicentric study". Trabalho apresentado em 7th i3S Annual Meeting 2019, Póvoa do Varzim, Portugal, 2019.
  3. Barrambana, S.; Correia, M.; Lima, A.R.; Pestana, A.; Lima, R.T.; Máximo, Valdemar. "Mitochondrial Dynamics in Thyroid Cancer: Unravelling the Role of DRP1". Trabalho apresentado em 11th Symposium on Metabolism (FMUP), 2019.
  4. Batista, Rui; Anacleto, Sara; Vinagre, João; Prazeres, Hugo; Gonçalves, David; Eufrásio, Pedro; Azinhais, Paulo; et al. "P19 - A novel urine test for non-muscle invasive bladder cancer recurrence detection - a Portuguese multicentric study". Trabalho apresentado em Congresso da Associação Portuguesa de Urologia, Funchal, Portugal, 2019.
  5. Barrambana, Sara; Correia, Marcelo; Lima, Ana Rita; Máximo, Valdemar. ""Dinâmica mitocondrial no cancro da tiróide: o papel da proteína DRP1"". Trabalho apresentado em Encontro Nacional de Jovens Investigadores em Oncologia, 2019.
  6. Barrambana, S.; Correia, M.; Lima, A.R.; Máximo, Valdemar. "Dinâmica Mitocondrial no Cancro da Tiróide: O Papel da DRP1". Trabalho apresentado em 1º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2019.
  7. Pereira B.; Dias, Alexandre; A. L. Amaral; N. Mendes; V. Muncan; A. R. Silva; C. Thibert; et al. "Mex3a deletion impairs Lgr5+ stem cell maintenance in the mouse gut". Trabalho apresentado em ISSCR International Symposium 2019: Stem cells and Organoids in Development and Disease, 2019.
  8. Pedro, Nicole; Cavadas, Bruno; Fernandes, Verónica; Falcão-Pires I; Leite-Moreira AF; Pinto do Ó P; Máximo, Valdemar; Pereira, Luisa. "Characterization of whole mitochondrial DNA diversity in heart failure with preserved ejection fraction". Trabalho apresentado em I3S Annual Meeting, 2018.
  9. Pereira B.; Dias, Alexandre; A. L. Amaral; V. Muncan; A. R. Silva; C. Thibert; A. G. Radu; et al. "MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium". Trabalho apresentado em i3S 7th Annual Meeting 2018, 2018.
  10. Pedro, Nicole; Cavadas, Bruno; Fernandes, Verónica; Falcão-Pires I; Leite-Moreira AF; Pinto do Ó P; Máximo, Valdemar; Pereira, Luisa. "Next-generation sequencing evaluation of mitochondial biomarkers in heart failure with preserved ejection fraction". Trabalho apresentado em MitoPorto ¿ Mitochondrial evolution, metabolism and disease, 2018.
  11. Pedro, Nicole; Cavadas, Bruno; Fernandes, Verónica; Falcão-Pires, Inês; Leite-Moreira AF; Pinto-do-Ó, Perpétua; Máximo, Valdemar; Pereira, Luisa. "Next-generation sequencing evaluation of mitochondrial biomarkers in heart failure with preserved ejection fraction (HFpEF)". Trabalho apresentado em MitoPorto 2018 - International Symposium in mitochondrial evolution, metabolism and disease, 2018.
  12. Silvana, M.; Correia, M.; Dias, A.G.; Pestana, A.; Boaventura, M.; Maximo, V.. "The role of mitochondria in the non-targeted effect of ionizing radiation". Trabalho apresentado em ESTRO 37, 2018.
  13. Miranda, S.; Correia, M.; Dias, A.G.; Pestana, A.; Boaventura, P.; Maximo, V.. "The importance of mitochondrial DNA in the radiation-induced bystander effect". Trabalho apresentado em VI Congresso da Sociedade Portuguesa de Radioterapia Oncologia, 2017.
  14. Pereira, JB; Cavadas, Bruno; Fernandes, Veronica; Eloy, Catarina; Sobrinho-Simões, Manuel; Soares, Paula; Samuels, DC; Máximo, Valdemar; Pereira, Luisa. "Omics characterization of the mitochondrial-rich oncocytic phenotype on a thyroid carcinoma background". Trabalho apresentado em 5th I3S Annual Meeting, 2016.
  15. Oliveira, Patricia; Carvalho, Joana; Rocha, Sara; Azevedo, Mafalda; Vieira, Andre F.; Ferreira, Daniel; Mendes, Nuno; et al. "Abstract 1611: Epithelial-mesenchymal-epithelial transition induced by long term exposure to TGFB1 creates cellular heterogeneity". Trabalho apresentado em AACR 107th Annual Meeting 2016, New Orleans, United States, 2016.
    10.1158/1538-7445.am2016-1611
  16. Pinheiro, P.; Correia, M.; Soares, P.; Pinto, M.; Máximo, Valdemar. "Characterization of Intracellular Lipid Droplets in Cancer Cells Harboring Mitochondrial Dysfunction". Trabalho apresentado em 5th i3S Annual Meeting, 2016.
  17. Pinheiro, P.; Correia, M.; Soares, P.; Pinto, M.; Máximo, Valdemar. "Mitochondrial DNA depletion re-programs the expression of fatty acid metabolism-related genes and leads to lipid droplet accumulation". Trabalho apresentado em 8th FMUP symposium on metabolism "Programação Metabólica", 2016.
  18. Mafalda Pinto; Pedro Pinheiro; Ricardo Coelho; Marcelo Correia; Paula Soares; Máximo, Valdemar. "Mitochondrial regultation of epigenetics". Trabalho apresentado em 5th i3S Annual Meeting, 2016.
  19. Pereira, JB; Cavadas, Bruno; Eloy, Catarina; Sobrinho-Simões, Manuel; Soares, Paula; Samuels, DC; Máximo, Valdemar; Pereira, Luisa. "Genetic landscape of oncocytic thyroid tumours". Trabalho apresentado em XXIII Porto Cancer Meeting, 2015.
  20. Melo, Miguel; Gaspar da Rocha, Adriana; Vinagre, João; Batista, Rui; Peixoto, Joana; Celestino, Ricardo; Salgado, Catarina; et al. "Prognostic significance of TERT promoter mutations in follicular cell-derived thyroid carcinomas". Trabalho apresentado em 16th European Congress of Endocrinology, Wroclaw, Poland, 2014.
    10.1530/endoabs.35.P1149
  21. Pereira, Sofia S; Máximo, Valdemar; Coelho, Ricardo; Vinagre, João; Morais, Tiago; Costa, Manuel; Soares, Paula; et al. "TERT promoter mutations and TERT expression in adrenocortical tissues". Trabalho apresentado em XX Curso Pós-Graduado de Endocrinologia, Diabetes e Metabolismo, Porto, Portugal, 2014.
  22. Nunes, J.; Soares, P.; Rocha, A.; Oliveira, M.; Paredes, J.; Rolo, A.; Mendes, N.; et al. "MtDNA-induced OXPHOS dysfunction causes enhanced tumour growth and metastatic potential: a role for OXPHOS in regulating migration?". Trabalho apresentado em 3rd I3S Scientific Retreat, 2012.
  23. Correia, M.; Dias, A.; Ferreira-da-Silva, A.; Rocha, A.; Lima, J.; Soares, P.; Máximo, Valdemar; Maximo, V.. "GRIM-19 expression in thyroid and kidney tumours". Trabalho apresentado em XXI Porto Cancer Meeting – Metabolism and Cancer: from Etiopathogenesis to Therapy, 2012.
  24. Oliveira, Patrícia Joana Morais Ferreira; Seruca, Raquel; Ferreira, Daniel; Azevedo, Mafalda; Vinagre, João; Mendes, Nuno; Carneiro, Fátima; et al. "An in vitro model for Epithelial-Mesenchymal-Epithelial transitions as a novel tool to study cancer progression". Trabalho apresentado em I3S Scientific Retreat, 2012.
  25. Lima, J.; Prazeres, H.; Soares, R.; Máximo, Valdemar; Soares, P.; Rodrigues, F.; Sobrinho-Simoes, M.. "Germline SDHD variants modulate the development of medullary thyroid carcinoma". Trabalho apresentado em 34th Annual Meeting of the European Thyroid Association 2009, 2009.
  26. Ferreira-da-Silva, A.; Máximo, Valdemar; Gomes, L.; Botelho, T.; Lima, J.; Soares, P.; Sobrinho-Simoes, M.. "Alterations of the inner mitochondrial membrane transporter TIMM44 in thyroid carcinomas". Trabalho apresentado em Euromit 7 - The seventh European Meeting on Mitochondrial Pathology - From basic mechanisms to disease and ageing, 2008.
  27. Vinagre, J.; Bento, I.; Ferreira-da-Silva, A.; Lima, J.; Soares, P.; Máximo, Valdemar; Vinagre, João; et al. "The role of GRIM-19 in thyroid tumours". Trabalho apresentado em SINAL 2008, 2008.
  28. Raquel, P.; Silva, P.; Máximo, Valdemar. "Expressão de MET em carcinomas papilares de células renais esporádicos". Trabalho apresentado em XII Congresso Nacional de Anatomia Patológica – XV reunião Anual da Sociedade Portuguesa de Citologia, 2007.
  29. Lima, J.; Teixeira-Gomes, J.; Soares, P.; Máximo, Valdemar; Honavar, M.; Williams, D.; Sobrinho-Simoes, M.. "Germeline SDHD mutation segregating with familial non-ret C-cell hyperplasia.". Trabalho apresentado em 29th European Thyroid Association Annual Meeting, 2003.
  30. Máximo, Valdemar; Soares, P.; Lima, J.; Taveira, A.; Capela, J.; Amaro, T.; Barbosa, A.P.; et al. "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumors of the thyroid". Trabalho apresentado em 29th European Thyroid Association Annual Meeting, 2003.
    10.1038/sj.bjc.6602547
  31. Máximo, Valdemar; Barbosa, A.P.; Amaro, T.; Soares, P.; Lima, J.; Taveira, A.; Capela, J.; et al. "Mutações germinativas e somáticas no GRIM-19, um gene envolvido no metabolismo mitocondrial e morte celular, associadas aos tumores da tireóide ricos em mitocôndrias". 2003.
  32. Lima, J.; Máximo, Valdemar; Soares, P.; Sobrinho-Simoes, M.. "Mitochondrial DNA alterations in post-Chernobyl thyroid tumours". Trabalho apresentado em XIIth EuroCellPath Course, 2002.
  33. Máximo, Valdemar; Soares, P.; Rocha, A.S.; Sobrinho-Simoes, M.. "Delecção comum mitocondrial presente em bócios e tumores da tireóide humana com e sem transformação oxifílica". Trabalho apresentado em 2ª Reunião da Sociedade Portuguesa de Genética Humana/2º Simpósio Luso-Brasileiro de Genética Médica, 1998.
  34. Rocha, A.S.; Soares, P.; Machado, J.C.; Máximo, Valdemar; Sobrinho-Simoes, M.. "Mutações do gene da caderina-E associam-se a fenótipos particulares do carcinoma da tireóide". Trabalho apresentado em 2ª Reunião da Sociedade Portuguesa de Genética Humana/2º Simpósio Luso-Brasileiro de Genética Médica, 1998.
  35. Máximo, Valdemar; Soares, P.; Rocha, A.S.; Sobrinho-Simoes, M.. "Uso de “differential display” no estudo da génese e progressão de tumores da tireóide humana". Trabalho apresentado em 2ª Reunião da Sociedade Portuguesa de Genética Humana/2º Simpósio Luso-Brasileiro de Genética Médica, 1988.
Resumo em conferência
  1. Dias, A; Batista, R; Lima, J; Soares, P; Maximo, V. "Insights into the regulation of GRIM-19 expression in renal cell carcinoma". 2013.
  2. Cameselle Teijeiro, J; Ferreira, R; Carames, N; Abdulkader, I; Maximo, V; Soares, P; Sobrinho Simoes, M. "Oncocytic (Hurthle cell) change in solid cell nests of the human thyroid gland". 2011.
  3. Machado, AM; Figueiredo, C; Touati, E; Maximo, V; Nielsen, FC; Seruca, R; Rasmussen, LJ. "H-pylori Infection Induces Genetic Instability of Nuclear and Mitochondrial DNA in Gastric Cells". 2009.
  4. Guimaraes, S; Leal, N; Maximo, V. "Somatic mutations in mitochondrial DNA of oncocytic cells in warthin tumours". 2009.
  5. Maximo, V; Figueiredo, C; Soares, P; Machado, JC; Carneiro, F; Seruca, R; Sobrinho Simoes, M. "Mitochondrial DNA (MTDNA) mutations in Helicobacter pylori chronic gastritis and gastric carcinoma". 2006.
  6. Figueiredo, C; Maximo, V; Soares, P; Machado, JC; Seruca, R; Carneiro, F; Sobrinho Simoes, M. "Mitochondrial DNA (mtDNA) mutations in Helicobacter pylori chronic gastritis and gastric carcinoma". 2006.
  7. Figueiredo, C; Maximo, V; Soares, P; Sousa, S; Carneiro, F; Seruca, R; Sobrinho Simoes, M. "mtDNA alterations in Helicobacter pylori chronic gastritis and gastric carcinoma". 2005.
  8. Maximo, V; Botelhol, T; Capela, J; Soares, P; Lima, J; Taveira, A; Amaro, T; et al. "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid". 2004.
  9. Lima, J; Soares, P; Maximo, V; Tronko, M; Bogdanova, T; Abrosimov, A; Thomas, G; Williams, D; Sobrinho Simoes, M. "Mitochondrial DNA alterations in post-Chernobyl thyroid tumours". 2004.
Tese / Dissertação
  1. Chantre, Ana Sofia Moreira. "Unravelling the role of mitochondrial TERT in a thyroid cancer cell line". Mestrado, 2023. http://hdl.handle.net/10400.22/24754.
  2. Valença, Isabel Cristina Pinto. "Unraveling the role of peroxisome dynamics in cancer development". Doutoramento, 2019. http://hdl.handle.net/10773/27984.
  3. Correia, Marcelo José Marques; Dias, Ana Isabel Mendes, 1989-. "The role of GRIM-19 and interacting proteins in human tumours". Mestrado, 2011. http://hdl.handle.net/10316/25671.
  4. Leal, Noémia Evelina Gonçalves da Costa. "Mutações e delecções do DNA mitocondrial (mtDNA) em oncocitomas renais e tumores de Warthin das glândulas salivares : comparação com tumores de células de Hürthle da tireóide". Mestrado, 2007. http://hdl.handle.net/1822/8071.

Outros

Outra produção
  1. Unravelling the Tumourigenesis Mechanisms of Oncocytic Cell Tumours: Discoveries from a Comparative Omics Study. 2024. Canberk, S.; Ferreira, M.; Paula, A.D.C.; Pereira, L.; Oliveira, C.; Osório, H.; Soares, P.; Máximo, V.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85212346281&partnerID=MN8TOARS.
    10.21203/rs.3.rs-5337626/v1
  2. Genomic profiling of lymph node and distant metastases from papillary and poorly differentiated thyroid carcinomas. 2024. Máximo, V.; Melo, M.; Sobrinho-Simões, M.; Soares, P.; Da Cruz Paula, A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85198456995&partnerID=MN8TOARS.
    10.21203/rs.3.rs-4528308/v1
  3. Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFß1 promotes tumour growth. 2021. Santos, M.; Ferreira, M.; Oliveira, P.; Mendes, N.; André, A.; Vieira, A.F.; Nunes, J.B.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85121541520&partnerID=MN8TOARS.
    10.1101/2021.11.02.466914
  4. Untitled. 2003. Lima, J; Maximo, V; Soares, P; Sobrinho Simoes, M. https://www.authenticus.pt/P-000-H61.
    10.1002/gcc.10147
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2014/02 Mitochondrial regulation of epigenetics and its role in human diseases 7th Meeting of Young Researchers of University of Porto
2013 Invited talk: "Mitochondria in cancer cells" 25th European Congress of Pathology - ECP 2013
(Lisboa, Portugal)
2013 Invited talk: "Alterações mitocondriais em cancro" Reuniões científicas do Centro de Investigação do IPOP
Centro de Investigação do IPOP (Porto, Portugal)
2012 Invited talk: "The role of metabolic enzymes alterations in cancer" XXI Porto Cancer Meeting – Metabolism and Cancer: from Etiopathogenesis to Therapy
Ipatimup (Porto, Portugal)
2012 Invited talk: "The metabolism of tumour cells" Advanced Course in “Metabolic Remodeling in Cancer”
Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2012 Invited talk: "Genetic causes for the Warburg Effect of tumour cells – insights from Hürthle cell thyroid tumours and inherited neoplastic syndromes" Advanced Course in “Metabolic Remodeling in Cancer”
Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2011 Invited talk: "Changes of metabolic enzymes in cancer" 15th Annual Meeting of the Portuguese Society for Human Genetics
Portuguese Society for Human Genetics (Lisboa, Portugal)
2011 Invited talk: "Thyroid cancer: a metabolic disorder" International Advanced Course on Endocrinology, Diabetes and Nutrition
(Porto, Portugal)
2010 Invited talk: "Krebs cycle and OXPHOS proteins in the origin of the Warburg effect in tumours" I3S Scientific Retreat
i3S (Póvoa do Varzim, Portugal)
2009/10 Status of the Mitochondrial Fusion and Fission proteins in the Oncocytic phenotype Cold Spring Harbor Meetings: Cell Death
2009/09 H-pylori Infection Induces Genetic Instability of Nuclear and Mitochondrial DNA in Gastric Cells 22nd International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer
(Porto)
2009 Invited talk: "Metabolic abnormalities in human tumours." International Meeting on Endocrinology
(Porto, Portugal)
2005/03 Invited talk: "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid." 1ª Reunião do Grupo de Patologia Endócrina do Hospital de S. João" - Recent advances in the diagnosis and treatment of thyroid cancer
Hospital de S. João (Porto)
2005 Invited talk: "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid." 1ª Reunião do Grupo de Patologia Endócrina do Hospital de S. João" - Recent advances in the diagnosis and treatment of thyroid cancer
(Porto, Portugal)
2003/10 BRAF mutations are associated with some histotypes of papillary thyroid carcinoma 29th European Thyroid Association Annual Meeting
European Thyroid Association (Edinburgh, Reino Unido)
2003/03 Invited talk: "Mutations in a dual functional gene (GRIM-19), involved in mitochondrial metabolism and cell death, in Hürthle cell tumours" XII Porto Cancer Meeting
Ipatimup
1999/10 A delecção comum mitocondrial (4997 ADNmt) está inversamente relacionada com a instabilidade de microssatélites no carcinoma gástrico 3ª Reunião da Sociedade Portuguesa de Genética Humana
Sociedade Portuguesa de Genética Humana

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018/11/08 - Atual The genetic basis and phenotypic variation of oncocytic tumors
Orientador de Sule Canberk
 Pathology and Molecular Genetics (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/10 - Atual Diabetes mellitus and oncytic tumours of thyroid: the mitochondrial connection.
Orientador
 Pathology and Molecular Genetics (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/10 - Atual Establishing a blood-stage infection: the role of amino acid metabolism in plasmodium development.
Orientador
 Basic and Applied Biology (Doutoramento)
Universidade do Porto, Portugal
2015 - Atual PhD supervision: "“Unravelling the genetics of Familial non-medullary thyroid carcinoma”
Orientador
 PhD Programme in Biomedicine (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2015 - Atual PhD supervision: “Role of mitochondrial fission protein -Drp1- as prognosis and predictive biomarker in the treatment of well carcinomas thyroid differential”
Orientador
 PhD Programme in Medicine and Molecular Oncology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2013/09/01 - Atual A morfologia, a genética e as alterações metabólicas nos tumores benignos e malignos do córtex e da medula da supra-renal
Coorientador
 Molecular medicine and oncology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2013 - Atual PhD co-supervision: “Morphology, genetics and metabolic changes in malignant and benign tumours of the adrenal gland”
Coorientador
 PhD Programme in Medicine and Molecular Oncology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2023/01/01 - 2026/12/31 Papel dos fármacos antidiabéticos no carcinoma diferenciado da tiroide: implicações da modulação do metabolismo energético na fisiopatologia e terapêutica do carcinoma papilar da tiroide
Orientador
 Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2022/09/05 - 2023/06/22 The role of 5-hydroxymethylcytosine as a potential epigenetic biomarker in a large series of thyroid neoplasm
Orientador
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2014/09/10 - 2021/04/15 Role of the MITOchondrial fission protein DRP1 as a prognosis and predictive biomarker in the treatment of differentiated thyroid cancer (ROMITO-DRP1).
Orientador
 Molecular Medicine and Oncology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2019/09/01 - 2020/12/11 Impact of mtDNA mutations on chromatin remodeling
Orientador
 Molecular Medicine and Oncology (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2018/09/10 - 2020/07/28 Mitochondrial complex II genetic characterization and enzymatic expression profile in tumours of the adrenal cortex and medulla
Orientador
 Master Degree in Medicine (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2015/09/01 - 2020/07/02 New Biomarkers development, validation and application in Bladder Cancer.
Orientador
 Doctoral Programme in Biomedicine (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2020 PhD co-supervision: “Unravelling the role of peroxisome dynamics in cancer progression”
Coorientador
 PhD Programme in Biomedicine (Doutoramento)
Universidade de Aveiro, Portugal
2018/09/01 - 2019/11/26 Mitochondrial dynamics in thyroid cancer: unravelling the role of DRP1
Orientador
 Master Degree in Oncology (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2018 Postdoc supervision: "Epigenetic regulation of mitochondrial DNA"
Orientador
 PostDoc (Outra)
2015 - 2018 Postdoc supervision: "Lipid metabolic switch in cancer models of mitochondrial dysfunction"
Orientador
 Postdoc; FCT Grant Ref. SFRH/BPD/109794/2015 (Outra)
2014 - 2018 Postdoc co-supervision: "Integrating Metabolic and Polarity Alterations in Cancer by post-transcriptional modulation of the LKB1-AMPK-mTOR axis (IMPACTOR): the role of the RNA-binding protein MEX3A"
Coorientador
 Postdoc; FCT Grant Ref. SFRH/BPD/109794/2015 (Outra)
2016/09/12 - 2017/12/05 Role of mitochondrial dynamics in Hürthle cell tumours: Coupling, uncoupling and fission
Orientador
 Oncologia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009/09/01 - 2017/03/20 Clinical, histological, and genetic characterization of papillary renal carcinoma (PRCC): diagnostic and therapeutic implications
Orientador
 Patologia e Genética Molecular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2017 MSc supervisor: "“Role of mitochondrial dynamics in Hürthle cell tumours: Coupling, uncoupling and fission”
Orientador
 Master Programme in Oncology (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2017 PhD supervision: “Clinical, histological, metabolic and genetic characterization of papillary renal cell carcinoma (PRCC): diagnostic and therapeutic implications”
Orientador
 PhD Programme in Pathology and Molecular Genetics (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2016 MSC co-supervision: “Evaluation of the impact of alternative splicing in thyroid cancer”
Coorientador
 Master in Informatics and Computer Engineering
Universidade do Porto Faculdade de Engenharia, Portugal
2014 - 2016 MSc supervision: “Characterization of intracellular lipid droplets in cancer cell displaying mitochondrial dysfunction”
Orientador
 Master Programme in Medicine and Molecular Oncology (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2012 - 2015 Supervisor of a Researcher Fellow (BI): "Mapping of genes predisposing to familial thyroid tumours. PIC/IC/83037/2007”
Orientador
2008 - 2015 PhD supervision: "Role of the mitochondrial biogenesis machinery in mitochondrion-rich tumours"
Orientador
 PhD Programme in Biomedicine (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2012/08/28 - 2013/12/11 Mitochondrial Regulation of Epigenetics and its Role in Human Diseases
Orientador
 Oncologia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 - 2013 MSc supervision: “Mitochondrial regulation of epigenetics and its role in human diseases”
Orientador
 Master Programme in Oncology (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2012 MSc supervision: “Role of GRIM-19 and STAT3 interaction in renal tumorigenese: clear cell renal cell carcinoma”
Orientador
 Master Programme in Human Biology and Environment (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2010 - 2012 Post-doc supervision: "Unveiling GRIM-19 functional role in cancer metabolism"
Orientador
 PostDoc (Outra)
2010 - 2011 MSc supervision: “Role of GRIM-19 and interacting proteins in human tumours”
Orientador
 Master Programme in Celular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - 2011 Postdoc supervision: "Targeting Metabolic Changes in Cancer Cells by Limiting Nutrient Availability"
Orientador
 Post-Doc, FCT Grant Ref. SFRH/BPD/66253/2009 (Outra)
2007 - 2008 MSc supervision: “Role of GRIM-19 in kidney carcinogenesis: evaluation of GRIM-19 expression and genetic alteration analysis in normal and tumoural kidney samples”
Orientador
 Master Programme in Molecular Medicine (Mestrado)
Cranfield University, Reino Unido
2007 - 2008 MSc supervision: “Study of mtDNA and GRIM-19 abnormalities in renal oncocytomas: comparison with Hürthle cell tumours of the thyroid”
Orientador
 Master Programme in Medicine and Molecular Oncology (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2006 - 2007 MSC supervision: “Mithochondrial DNA (mtDNA) mutations and deletions in renal oncocitomas and Warthin’s tumours of the parotid gland: a comparative study with Hürthle cell thyroid tumours”
Orientador
 Master Programme in Molecular Genetics (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
2005 - 2005 Supervision of a Research fellow (BI): "Mitochondrial DNA (mtDNA) mutations and deletions in thyroid Hürthle cell tumours: Characterisation, prognosis and association with mtDNA polymorphisms. POCTI/NSE/41055/2001"
Orientador
2002 - 2004 Supervision of a Research fellow (BI): “Mitochondrial DNA (mtDNA) mutations and deletions in thyroid Hürthle cell tumours: Characterisation, prognosis and association with mtDNA polymorphisms. POCTI/NSE/41055/2001”
Orientador
2003 - 2003 Supervision of the graduation thesis in Biology of the project: “Mitochondrial DNA (mtDNA) mutations and deletions in thyroid Hürthle cell tumours: Characterisation, prognosis and association with mtDNA polymorphisms. POCTI/NSE/41055/2001”
Orientador
 Biologia (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2002 - 2003 Supervision of a Research fellow (BI): “Mitochondrial DNA deletions and mutations in post-Chernobyl thyroid tumours and in the respective normal thyroid parenchyma. POCTI/CBO/43944/2001”
Orientador

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2025/01/09 "Exploration of glucose metabolism in acute myeloid leukemia: effect of 3- bromopyruvate in the response to chemotherapy"
Arguente
 Joana Margarida Pereira Vieira (Doutoramento)
Universidade do Minho, Portugal
2024/12/09 Bio-Distribution of Pancreas-Derived Exosomes
Presidente do júri
 Sara Raquel Sousa Alves (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2024/11/08 Exploring the Contribution of Ovarian Ageing Hallmarks to the Development of Preneoplastic Lesions
Presidente do júri
 Catarina Isabel Fonseca Brandão (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2024/02/05 “Cysteine Metabolic Remodeling: A Metabolic Marker for Cancer Aggressiveness and a Novel Putative Target in Oncological Management”
Arguente principal
 Ana Rita Crispim Hipólito (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/12/18 O Papel do Metaboloma no Acidente Vascular Cerebral Isquémico
Presidente do júri
 ana beatriz da costa baptista (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2023/11/29 Elucidation of the inflammatory pathways in human endometriosis
Presidente do júri
 Maria Flores Alves Botelho (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2023/11/24 “The Role of Glucagon: GCGR Axis in Pancreatic Neuroendocrine Tumours (pNETs)”
Arguente principal
 Bárbara Carina de Poeiras Ferreira (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/05/31 A systematic scoping review of vascular cell senescence in atherosclerosis: An innovative perspective and therapeutic approach
Presidente do júri
 José Alexander dos Santos de Canha (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2023/05/24 The role of 5-hydroxymethylcytosine as a potential epigenetic biomarker in a large series of thyroid neoplasm
Orientador
 João Pedro Cerveira Gonçalves (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2021/11/18 Metabolic and gene expression profiles related to EGFR mutation in lung cancer
Arguente principal
 Isabel Maria da Rocha da Costa Lemos (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2021/06/17 Podocitopatia lúpica: uma visão geral sobre esta nova variante histológica.
Presidente do júri
 Carolina da Conceição Carneiro Pais (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2021/05/14 Impact of nutrition and polyphenols on the pathophysiology of endometriosis: a systematic review.
Presidente do júri
 Mariana Torres dos Santos Hipólito Reis (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2021/04/15 Role of the MITOchondrial fission protein DRP1 as a prognosis and predictive biomarker in the treatment of differentiated thyroid cancer (ROMITO-DRP1).
Orientador
 Ana Rita Marçal Dantas de Lima (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2020/12/11 Impact of mtDNA mutations on chromatin remodeling
Orientador
 Diogo Manuel de Castro Abreu (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020/07/28 TERT promoter mutational status in cutaneous melanoma: an alternative to sentinel lymph node biopsy?
Presidente do júri
 Francisco Palhavã de Almeida Andrade Martins (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020/07/28 Mitochondrial complex II genetic characterization and enzymatic expression profile in tumours of the adrenal cortex and medulla
Orientador
 Mariana Isabel Cerqueira Seco (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020/07/28 The role of the glutamine transporter ASCT2 in antineoplastic therapy
Presidente do júri
 Estefania Curralo da Cruz Pereira Teixeira (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020/07/21 New Biomarkers development, validation and application in Bladder Cancer.
Orientador
 Rui Pedro Monteiro Batista (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2020/07/15 Metabolic characterization of testicular tumors: a role of epigenetic landscape
Arguente principal
 Ana Beatriz Ferreira Costa (Outro)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/11/26 Mitochondrial dynamics in thyroid cancer: unravelling the role of DRP1
Orientador
 Sara Alexandra de Sousa Barrambana (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/07/12 Telomere biology of cutaneous T-Cell lymphomas
Arguente principal
 Joana Alves Ropio (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/04/02 Cysteine, a facilitator of hypoxia adaptation and a promoter of drug-resistance : a new route to better diagnose and treat ovarian cancer patients
Arguente principal
 ANA SOFIA DE ALMEIDA COSTA NUNES (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/12/14 Selection on the mitochondrial haplogroup H in Homo sapiens and its putative role in protecting against sepsis
Arguente principal
 Hugo Blanquet Cruz Oliveira (Mestrado)
Universidade do Minho Departamento de Biologia, Portugal
2018/11/21 Monocarboxylate Transporters (MCTs) in Kidney Cancer: The Role of Epigenetic Mechanism
Arguente principal
 Ana Luisa Pereira Pinto (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/10/19 Cysteine uptake capacity is a relevant mechanism of resistance to platinum salts, in ovarian cancer
Arguente principal
 Inês Pires dos Santos (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/25 The Metabolic Needs of Epithelial to Mesenchymal Transition
Arguente
 Joana Catarina Brás Gomes Nunes (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018/01/12 Study of TGF-ß1 in the differentiated thyroid carcinoma
Arguente principal
 Karina Colombera Perez (Mestrado)
Universidade Estadual de Campinas, Brasil
2017/09/18 The pathogenic role of mTOR pathway in papillary thyroid carcinoma and its impact on sodium iodide symporter (NIS) expression
Vogal
 Ana Catarina Marques Gomes Tavares (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2016/12/19 Characterization of Intracellular Lipid Droplets in Cancer Cells Harboring Mitochondrial Dysfunction: Emphasis on Fatty Acid Metabolism
Orientador
 Pedro Filipe da Silva Pinheiro (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2016/12/16 Monocarboxylate transporters in gliomas: regulation and therapeutic implications
Arguente principal
 Vera Mónica Miranda Gonçalves (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2016/02/23 An approach to molecular genetics of thyroid cancer: from novel mutations to a zebrafish model
Vogal
 Ana Inês Lourenço de Almeida (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/12/11 Protein-based nanodevices for therapeutic applications
Arguente principal
 Ana Isabel Sá Loureiro (Doutoramento)
Universidade do Minho Escola de Ciências, Portugal
2015/09/29 Role of the Mitochondrial Biogenesis Dynamics Proteins in the Mitochondrion-rich Tumours
Orientador
 André Emanuel Ferreira da Silva (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2015/05/18 Unraveling cancer metabolism through flux analysis and metabolic engineering
Arguente principal
 Ludgero Canario Tavares (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07/31 Pathology, therapy, and prognosis of papillary renal carcinoma
Arguente principal
 Diana da Silva Fernandes (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2012/10/08 Regulation of Signal Transducer and Activator of Transcription (Stat) 3 in Human Cancers with Braf Activation
Vogal
 Joana Pinto do Couto e Silva (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

Membro de associação

Nome da associação Tipo de participação
2013/06/06 - Atual The European Association for Cancer Research -EACR, Membership number: EACR18659. Membership
2013/06/06 - Atual ASPIC | Associação Portuguesa de Investigação em Cancro - Sócio ASPIC89 Member
Distinções

Prémio

2023 Bolsa Prof. Edward Limbert/SPEDM/MERCK
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal
2021 "BOLSA EDWARD LIMBERT- MERCK/SPEDM- Ano 2021"
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal

Outra distinção

2023 Grant - Research Project - Decode metastatic thyroid cancer
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal