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André Raposo Moreira Dias took his BSc degree in Biochemistry (Jul 2011) at New University of Lisbon (final grade 15/20). After receiving his MSc in Medicinal Chemistry (Dec 2013) from Faculty of Pharmacy – University of Lisbon (final grade 17/20) and his PhD in Chemistry (Sep 2018) from University of Milano (Italy) the candidate joined Prof. Pedro Gois’ group for postdoctoral studies (Oct 2018) in a bioorganic chemistry research project (supported by FCT). The candidate began his research career in 2013 during his MSc thesis where he integrated the group of Prof. Rui Moreira (FFUL) on the “Development of chemical tools to study the mechanism of action of new 4-aminoquinazolines as inhibitors of malaria liver stage”. Later on, the candidate worked with Dr. Ana Ressurreição (Prof. Rui Moreira’s group) in a MSc fellowship awarded by FCT (2014-2015, carrying on MSc project): “Bioorthogonal clickable probes to target the liver stage of malaria”. From this period, resulted a publication in a book chapter (book of organic chemistry experiments for the laboratory classroom that was published by the Royal Society of Chemistry in 2016) and another paper is being built up. In June 2015, the candidate moved to Milano where he started his PhD fellowship supervised by Prof. Cesare Gennari (University of Milano, Italy) and Prof. Norbert Sewald (University of Bielefeld, Germany) in a Marie Sklodowska-Curie ITN fellowship called MAGICBULLET. During his PhD, the candidate worked on cancer therapy field in the synthesis of Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy (one project in collaboration with Bayer AG, Germany). The candidate developed new RDG-Drug conjugates with high affinity for avß3 integrin (overexpressed receptor in tumors). During his academic secondment (Oct 2016-Apr 2017) in Bielefeld (Germany), the candidate worked on the synthesis of new anticancer agents bearing cryptophycin as cytotoxic drug. Moreover, the candidate joined Italfarmaco SpA (Italy) industry for a 3-month (Jan 2018-Mar 2018) secondment supervised by Dr. Christian Steinkühler on the synthesis of RGD-Auristatin conjugates for targeted delivery in tumors. The candidate published 2 first-author papers in Chem. Eur. J. and 1 co-author in Eur. J. Org. Chem. By now, 2 additional papers are being submitted related with the work done in both secondments. During his PhD period, the candidate supervised one undergraduate student and was awarded with two best poster prizes in two international conferences “Rimini Peptides Conference 2018” / “Bologna Peptides Conference 2016”. Moreover, the candidate gave one oral communication in an italian meeting dedicated to the latest findings by the young researchers (NEXT STEP EVENT 2016, Milano) and several presentations within the ITN network meetings. Currently, the candidate is based in Lisbon where he is starting his postdoctoral research on stimulus responsive click chemistry: the first triggerable tetrazine ligation”. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Malária; Tumor Targeting; Selectivity; 4-aminoquinazolines; SAR; Medicinal Chemistry; Small molecule-drug conjugates; Cancer; RGD and Integrins.
Identificação

Identificação pessoal

Nome completo
André Filipe Raposo Moreira Dias

Nomes de citação

  • Dias, André

Identificadores de autor

Ciência ID
D815-F3B0-F2E4
ORCID iD
0000-0001-6335-1156

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Italiano Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2015/06/01 - 2018/09/07
Concluído
Chemistry (Doutoramento)
Università degli Studi di Milano, Itália
"Synthesis of RGD Peptidomimetic-Drug Conjugates for the Tumor-Targeted Delivery of Cytotoxic Agents" (TESE/DISSERTAÇÃO)
2012/10/01 - 2013/12/20
Concluído
Medicinal Chemistry (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Development of chemical tools to study the mechanism of action of new 4-aminoquinazolines as inhibitors of malaria liver stage" (TESE/DISSERTAÇÃO)
17/20
2008/09/01 - 2011/07/20
Concluído
Biochemistry (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Biochemical characterization of chlorite dismutase of Dechlorospirillum sp." (TESE/DISSERTAÇÃO)
15/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2018/10/01 - Atual Pós-doutorado (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/06/01 - 2018/09/07 Investigador (Investigação) Università degli Studi di Milano, Itália
2018/01/01 - 2018/03/31 Investigador visitante (Investigação) Italfarmaco SpA, Itália
2016/10/01 - 2017/03/31 Investigador visitante (Investigação) Universität Bielefeld, Alemanha
2014/01/07 - 2015/04/30 Investigador Contratado (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/01/07 - 2011/07/20 Estagiário de Investigação (Investigação) REQUIMTE, Portugal
Projetos

Projeto

Designação Financiadores
2018/10/01 - Atual Stimulus Responsive Click Chemistry: The First Triggerable Tetrazine Ligation
Bolseiro de Pós-Doutoramento
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2015/06/01 - 2018/09/07 Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy
Bolseiro de Doutoramento
Università degli Studi di Milano, Itália
EU Framework Programme for Research and Innovation Science with and for Society

Horizon 2020 European Innovation Council Fast Track to Innovation
Concluído
2014/04/15 - 2015/04 BioClick@LSMal. Bioorthogonal clickable probes to target the liver stage of malaria
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2012/10/01 - 2013/12/20 Development of chemical tools to study the mechanism of action of new 4-aminoquinazolines as inhibitors of malaria liver stage
Bolseiro de Mestrado
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/03 - 2011/07/20 Biochemical characterization of chlorite dismutase of Dechlorospirillum sp.
Outra
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Concluído
Produções

Publicações

Artigo em revista
  1. André Raposo Moreira Dias; Arianna Pina; Amelia Dean; Hans-Georg Lerchen; Michele Caruso; Fabio Gasparri; Ivan Fraietta; et al. "Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate". Chemistry - A European Journal 2019 25 (2018): 1696-1700. https://doi.org/10.1002/chem.201805447.
    Acesso aberto • Publicado • 10.1002/chem.201805447
  2. Paula López Rivas; Ivan Randelovic; André Raposo Moreira Dias; Arianna Pina; Daniela Arosio; József Tóvári; Gábor Mezo; et al. "Synthesis and Biological Evaluation of Paclitaxel Conjugates Involving Linkers Cleavable by Lysosomal Enzymes and aV ß3 -Integrin Ligands for Tumor Targeting". European Journal of Organic Chemistry 2018 23 (2018): 2902-2909. https://doi.org/10.1002/ejoc.201800447.
    10.1002/ejoc.201800447
  3. André Raposo Moreira Dias; Arianna Pina; Alberto Dal Corso; Daniela Arosio; Laura Belvisi; Luca Pignataro; Michele Caruso; Cesare Gennari. "Frontispiece: Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin aV ß3". Chemistry - A European Journal 23 58 (2017): https://doi.org/10.1002/chem.201785863.
    10.1002/chem.201785863
  4. André Raposo Moreira Dias; Arianna Pina; Alberto Dal Corso; Daniela Arosio; Laura Belvisi; Luca Pignataro; Michele Caruso; Cesare Gennari. "Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin aV ß3". Chemistry - A European Journal 23 58 (2017): 14410-14415. https://doi.org/10.1002/chem.201703093.
    10.1002/chem.201703093
  5. Freire, D.M.; Rivas, M.G.; Dias, A.M.; Lopes, A.T.; Costa, C.; Santos-Silva, T.; Van Doorslaer, S.; González, P.J.. "The homopentameric chlorite dismutase from Magnetospirillum sp.". Journal of Inorganic Biochemistry 151 (2015): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937905674&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2015.07.006
Capítulo de livro
  1. Dias, André; Moreira, Rui Ferreira Alves; Dra. Ana S. Ressurreição. "One-Step Synthesis of 4(3H)-Quinazolinones: An Important Heterocyclic Scaffold in Medicinal Chemistry". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 84-86. The Royal Society of Chemistry: Cambridge, 2016.
    Publicado
Poster em conferência
  1. Dias, André. "TUMOR TARGETING WITH RGD-PACLITAXEL CONJUGATES BEARING AN EXTRACELLULARLY CLEAVABLE LINKER". Trabalho apresentado em Rimini Peptides Conference 2018, 2018.
  2. Dias, André. "SYNTHESIS OF MULTIMERIC INTEGRIN LIGANDS FOR THE SELECTIVE TUMOR-TARGETED DELIVERY OF CYTOTOXIC DRUGS". Trabalho apresentado em Bologna Peptides Conference 2016, 2016.
  3. Dias, André. "Quinazolines as Potent and Selective Liver-Stage Malaria Inhibitors". Trabalho apresentado em EFMC-ISMC 2014, Lisbon, 2014.
  4. Dias, André. "Quinazolines as Potent and Selective Liver-Stage Malaria Inhibitors". Trabalho apresentado em EFMC-YMCS 2014 - 1st EFMC Young Medicinal Chemist Symposium, Lisbon, 2014.
  5. Dias, André. "Development of chemical tools to study the mechanism of action of potent quinazolines targeting the liver-stage of malaria infection". Trabalho apresentado em 1st Portuguese-Brazilian Organic Chemistry Symposium, 2013.
  6. Dias, André. "Quinazolines as a potent and selective liver-stage malaria inhibitors". Trabalho apresentado em ESPCA-Chemistry, Araraquara - Brazil, 2013.
  7. Dias, André. "Development of chemical tools to study the mechanism of action of potent quinazolines targeting the liver stage of malaria infection". Trabalho apresentado em 5th iMed.UL Postgraduate Students Meeting, Lisbon, 2013.
Tese / Dissertação
  1. Dias, André. "SYNTHESIS OF RGD PEPTIDOMIMETIC-DRUG CONJUGATES FOR THE TUMOR-TARGETED DELIVERY OF CYTOTOXIC AGENTS". Doutoramento, Università degli Studi di Milano Collegio Didattico del Dipartimento di Chimica, 2018. https://air.unimi.it/handle/2434/583313#.XGbclVz7TIU.
  2. Moreira, Rui Ferreira Alves; Ressureição, Ana Sofia Marques da; Dias, André Filipe Raposo Moreira. "Desenvolvimento de ferramentas químicas para estudar o mecanismo de acção de novas 4-aminoquinazolinas como inibidores da fase hepática da malária". Mestrado, 2013. http://hdl.handle.net/10451/15893.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2016/07/11 SYNTHESIS OF MULTIMERIC INTEGRIN LIGANDS FOR THE SELECTIVE TUMOR-TARGETED DELIVERY OF CYTOTOXIC DRUGS NEXT STEP EVENT, Milan
University of Milano (Milano, Itália)

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2019/01/28 Synthesis of a readily functionalizable 2-FBBA derivative
Arguente principal
Catarina de Oliveira Belmonte Silvério (Outro)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2019/01/28 Tumor Targeting Using Cancer-Associated Inflammation ChemPubSoc Europe Logo Author: Chemistry – A European Journal Published Date: 28 Janeiro 2019 Source / Publisher: Chemistry – A European Journal/Wiley-VCH Copyright: Wiley-VCH Verlag GmbH & Co. KGaA Magazine: Carrier Systems for CO

Tutoria

Tópico Nome do aluno
2019/01/03 - Atual Synthesis of a boronated pyochelin siderophore Ana Cláudia Negrão
2018/10/01 - 2018/12/31 Synthesis of boronated Pyochelin with antibacterial activity Ana Martins
Distinções

Prémio

2018 Best poster prize, TUMOR TARGETING WITH RGD-PACLITAXEL CONJUGATES BEARING AN EXTRACELLULARLY CLEAVABLE LINKER
Università degli Studi di Bologna, Itália
2016 Best poster prize, SYNTHESIS OF MULTIMERIC INTEGRIN LIGANDS FOR THE SELECTIVE TUMOR-TARGETED DELIVERY OF CYTOTOXIC DRUGS
Università degli Studi di Bologna, Itália