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Pedro Martins, born in 1977, graduated in 2000 with top-ranked classifications in Chemical Engineering from the Faculty of Engineering of the University of Porto (FEUP) was for this reason awarded with the 'José Magalhães Ramos Award' and the 'Engenheiro António de Almeida Award' in 2000. From 2001 to 2006 he conducted his PhD studies in Chemical Engineering at FEUP supported by a PhD Scholarship from FCT and research grants from the Calouste Gulbenkian Foundation and Fulbright Commission. His PhD Thesis was distinguished with the 2008 Excellence Award in Crystallization of the European Federation of Chemical Engineering. From February 2006 to April 2007, Pedro was Assistant Professor (Research) at the Audubon Sugar Institute, Louisiana State University, USA. He returned to Portugal for a FCT Post-Doc project at the Instituto de Biologia Molecular e Celular (IBMC), where he became responsible for an FCT project in the field of protein crystallization. In 2011 Pedro completed the co-supervision of a PhD student and of a Research Fellow and subsequently started the supervision of 1 Post-Doc and 3 PhD students. Pedro was a full-time Assistant Professor in the Molecular Biology Department of Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto lecturing Biophysics and Drug Design subjects to Health Sciences students. He was awarded with the 2013/14 Grant for Young Professors 'Santander Universidades' and with the 2015 Erasmus+ Mobility Programme. Pedro has several participations in International Conferences and has been distinguished with best poster and best talk awards. By March 2022, Pedro's track record of publications comprised 39 papers in international journals, 5 papers in Conference Proceedings and 10 invited oral presentations in International Conferences. Pedro's 2012 publication in Journal of Biological Chemistry was distinguished by the Editorial Board as the top 2% papers published by the journal during that year. In 2015 Pedro and his team published in FEBS Journal the long-sought, closed-form solution of the Briggs and Haldane enzyme kinetics mechanism, of which the century-old Michaelis-Menten equation provides the better known approximate solution. Pedro integrated the Laboratory for Process Engineering, Environmental, Biotechnology and Energy (LEPABE) until 2017; in 2016 he launched an independent translational project oriented for 'intelligent' screenings of new drugs in collaboration with partners from Industry and Academia. Since April 2017, Pedro holds Research Assistant position at the Biomolecular Structure and Function group of i3S working on rational drug discovery in Parkinson's disease and Machado-Joseph disease.
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Identificação

Identificação pessoal

Nome completo
Pedro Miguel Martins

Nomes de citação

  • Martins, Pedro

Identificadores de autor

Ciência ID
E316-A5F4-3F50
ORCID iD
0000-0002-6908-1828
Formação
Grau Classificação
2006
Concluído
 Doutoramento em Engenharia Química (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
"Modelling crystal growth from pure and impure solutions - a case study on sucrose" (TESE/DISSERTAÇÃO)
 PhD
2006
Concluído
 Engenharia Química (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Faculdade de Engenharia, Portugal
"Modelling Crystal Growth from Pure and Impure Solutions - a Case Study on Sucrose" (TESE/DISSERTAÇÃO)
2000
Concluído
 Engenharia Química (Licenciatura)
Universidade do Porto Faculdade de Engenharia, Portugal
"-" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/04/01 - 2024/04/01 Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/04/01 - 2019/04/01 Investigador Auxiliar (carreira) (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/09/01 - 2017/03/31 Investigador principal (carreira) (Investigação) Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal
2007/05/01 - 2009/09/01 Pós-doutorado (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/01/01 - 2007/04/01 Investigador principal (carreira) (Investigação) Louisiana State University, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2009/11/01 - 2015/09/30 Professor Auxiliar (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2015 Professor Auxiliar (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2015 Professor Auxiliar (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009 - 2015 Professor Auxiliar (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projetos

Bolsa

Designação Financiadores
2025/02/01 - Atual DRUG4AL(L)S: Interfacial modulation of protein solubility as a key to the discovery of new drugs for Amyotrophic Lateral Sclerosis
2023.11892.PEX
Investigador responsável
Em curso

Projeto

Designação Financiadores
2022/01/01 - 2024/12/31 Colloid aggregation activity of intrinsically disordered polypeptides that phase separate into neurotoxic condensates
PTDC/QUI-COL/2444/2021
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/03/01 - 2024/02/29 Novel approaches to the development of next-generation antithrombotic leads
PTDC/BIA-BQM/2494/2020
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2021/12/31 Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas
PTDC/MED-FAR/31323/2017
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Desenvolvimento de ferramenta moleculares para a doença de Machado-Joseph: moduladores de conformações tóxicas em proteínas com poliglutaminas.
PTDC/BIA-BFS/31173/2017
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2010/04/15 - 2013/04/14 Crescimento de Cristais de Proteínas com Propriedades de Difracção de Raios-X de Elevada Qualidade
PTDC/BIA-PRO/101260/2008
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/04 Crystal growth engineering used to improve the X-ray diffraction properties of protein crystals
PTDC/BIA-PRO/101260/2008
 Universidade do Algarve Faculdade de Ciências e Tecnologia
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/12/15 - 2011/02/28 Ciência do crescimento cristalino: novas aplicações na cristalização de sacarose e proteínas em soluções puras e impuras
PTDC/EQU-FTT/81496/2006
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Centro de Investigação em Sistemas e Tecnologias, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/05/01 - 2009/10/31 CRISTALIZAÇÃO DE PROTEÍNAS PARA FINS FARMACÊUTICOS, BIOQUÍMICOS E BIOMÉDICOS
SFRH/BPD/34556/2007
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2001/01/01 - 2004/12/31 CARACTERIZAÇÃO DA TRANSFERÊNCIA DE IMPUREZAS PARA OS CRISTAIS EM PROCESSOS INDUSTRIAIS
SFRH/BD/3428/2000
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2019 - 2020 Targeting diffusible oligomers of alpha-synuclein for the treatment of Parkinson´s disease
CORBEL ID 5827
Investigador responsável
Leibniz-Institut für Molekulare Pharmakologie, Alemanha

Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine, Itália
Horizon 2020
Em curso
Produções

Publicações

Artigo em revista
  1. Zsuzsa Sárkány; Francisco Figueiredo; Sandra Macedo-Ribeiro; Pedro M. Martins. "NAGPKin: Nucleation-and-growth parameters from the kinetics of protein phase separation". Molecular Biology of the Cell (2024): https://doi.org/10.1091/mbc.E23-07-0289.
    10.1091/mbc.E23-07-0289
  2. Zsuzsa Sárkány; Fernando Rocha; Anna Bratek-Skicki; Peter Tompa; Sandra Macedo-Ribeiro; Pedro M. Martins. "Quantification of Surface Tension Effects and Nucleation-and-Growth Rates during Self-Assembly of Biological Condensates". Advanced Science (2023): https://doi.org/10.1002/advs.202301501.
    10.1002/advs.202301501
  3. Simone Lauterbach; Hannah Dienhart; Jan Range; Stephan Malzacher; Jan-Dirk Spöring; Dörte Rother; Maria Filipa Pinto; et al. "EnzymeML: seamless data flow and modeling of enzymatic data". Nature Methods 20 3 (2023): 400-402. http://dx.doi.org/10.1038/s41592-022-01763-1.
    10.1038/s41592-022-01763-1
  4. Francisco Figueiredo; Mónica Lopes-Marques; Bruno Almeida; Nena Matscheko; Pedro M. Martins; Alexandra Silva; Sandra Macedo-Ribeiro. "A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly". Cells 11 12 (2022): 1969-1969. https://doi.org/10.3390/cells11121969.
    10.3390/cells11121969
  5. Martins, Pedro. "MIRRAGGE - Minimum Information Required for Reproducible AGGregation Experiments.". Frontiers in molecular neuroscience (2020): https://europepmc.org/articles/PMC7729192.
    10.3389/fnmol.2020.582488
  6. Martins, Pedro. "Major Improvements in Robustness and Efficiency during the Screening of Novel Enzyme Effectors by the 3-Point Kinetics Assay.". SLAS discovery : advancing life sciences R & D (2020): https://doi.org/10.1177/2472555220958386.
    10.1177/2472555220958386
  7. Martins, Pedro. "interferENZY: A Web-Based Tool for Enzymatic Assay Validation and Standardized Kinetic Analysis.". Journal of molecular biology (2020): https://doi.org/10.1016/j.jmb.2020.07.025.
    10.1016/j.jmb.2020.07.025
  8. Cecília Ferreira; Maria Filipa Pinto; Sandra Macedo-Ribeiro; Pedro José Barbosa Pereira; Fernando Alberto Rocha; Pedro Miguel Martins. "Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions". Physical Chemistry Chemical Physics (2020): https://doi.org/10.1039/D0CP02469D.
    10.1039/D0CP02469D
  9. Emma E. Watson; Jorge Ripoll-Rozada; Ashley C. Lee; Mike C. L. Wu; Charlotte Franck; Tim Pasch; Bhavesh Premdjee; et al. "Rapid assembly and profiling of an anticoagulant sulfoprotein library". Proceedings of the National Academy of Sciences 116 28 (2019): 13873-13878. https://doi.org/10.1073/pnas.1905177116.
    10.1073/pnas.1905177116
  10. Martins, Pedro. "A simple linearization method unveils hidden enzymatic assay interferences.". Biophysical chemistry (2019): https://doi.org/10.1016/j.bpc.2019.106193.
    10.1016/j.bpc.2019.106193
  11. Zsuzsa Sárkány; Fernando Rocha; Ana M. Damas; Sandra Macedo-Ribeiro; Pedro M. Martins. "Chemical Kinetic Strategies for High-Throughput Screening of Protein Aggregation Modulators". Chemistry - An Asian Journal (2019): https://doi.org/10.1002/asia.201801703.
    10.1002/asia.201801703
  12. Alexandra Silva; Zsuzsa Sarkany; Joana Fraga; Pablo Taboada; Sandra Macedo-Ribeiro; Pedro Miguel Martins. "Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws". Biomolecules (2018): http://www.mdpi.com/2218-273X/8/4/108.
    10.3390/biom8040108
  13. Alexandra Silva; Bruno Almeida; Joana S. Fraga; Pablo Taboada; Pedro M. Martins; Sandra Macedo-Ribeiro. "Distribution of Amyloid-Like and Oligomeric Species from Protein Aggregation Kinetics". Angewandte Chemie International Edition 56 45 (2017): 14042-14045. https://doi.org/10.1002/anie.201707345.
    10.1002/ange.201707345
  14. Cecilia Ferreira; Silvia Barbosa; Pablo Taboada; Fernando A. Rocha; Ana M. Damas; Pedro M. Martins. "The nucleation of protein crystals as a race against time with on- and off-pathways". Journal of Applied Crystallography 50 4 (2017): 1056-1065. https://doi.org/10.1107%2Fs1600576717007312.
    10.1107/S1600576717007312
  15. Rosa Crespo; Eva Villar-Alvarez; Pablo Taboada; Fernando A. Rocha; Ana M. Damas; Pedro M. Martins. "Insoluble Off-Pathway Aggregates as Crowding Agents during Amyloid Fibril Formation". The Journal of Physical Chemistry B 121 10 (2017): 2288-2298. https://doi.org/10.1021/acs.jpcb.7b01120.
    10.1021/acs.jpcb.7b01120
  16. Martins, Pedro. "The Finding of Nondissolving Lysozyme Crystals and Its Significance for the Study of Hard-to-Crystallize Biological Macromolecules". Crystal Growth & Design 16 8 (2016): 4285-4291. http://pubs.acs.org/doi/abs/10.1021/acs.cgd.6b00334.
    10.1021/acs.cgd.6b00334
  17. Martins, Pedro. "In search of lost time constants and of non-Michaelis–Menten parameters". Perspectives in Science 9 (2016): 8-16. https://www.sciencedirect.com/science/article/pii/S2213020916302300.
    https://doi.org/10.1016/j.pisc.2016.03.024
  18. Crespo, Rosa; Villar-Alvarez, Eva; Taboada, Pablo; Rocha, Fernando A.; Damas, Ana M.; Martins, Pedro M.. "What can the kinetics of amyloid fibril formation tell about off-pathway aggregation?". Journal of Biological Chemistry (2015): http://www.jbc.org/content/early/2015/11/24/jbc.M115.699348.abstract.
    10.1074/jbc.M115.699348
  19. Pinto, M.F.; Estevinho, B.N.; Crespo, R.; Rocha, F.A.; Damas, A.M.; Martins, P.M.. "Enzyme kinetics: The whole picture reveals hidden meanings". FEBS Journal (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927596389&partnerID=MN8TOARS.
    10.1111/febs.13275
  20. Loureiro, J.A.; Crespo, R.; Börner, H.; Martins, P.M.; Rocha, F.A.; Coelho, M.; Carmo Pereira, M.; Rocha, S.. "Fluorinated beta-sheet breaker peptides". Journal of Materials Chemistry B 2 16 (2014): 2259-2264. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897385877&partnerID=MN8TOARS.
    10.1039/c3tb21483d
  21. Estevinho, B.N.; Damas, A.M.; Martins, P.; Rocha, F.. "The Influence of Microencapsulation with a Modified Chitosan (Water Soluble) on ß-Galactosidase Activity". Drying Technology 32 13 (2014): 1575-1586. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906263332&partnerID=40&md5=38cf216f3f0bb538962a0ae26f58df84.
    10.1080/07373937.2014.909843
  22. Estevinho, B.N.; Damas, A.M.; Martins, P.; Rocha, F.. "Microencapsulation of ß-galactosidase with different biopolymers by a spray-drying process". Food Research International 64 (2014): 134-140. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903457233&partnerID=40&md5=e0000b5fdaf6c84ff7c76cac53701b39.
    10.1016/j.foodres.2014.05.057
  23. Ferreira, C.; Rocha, F.A.; Damas, A.M.; Martins, P.M.. "On growth rate hysteresis and catastrophic crystal growth". Journal of Crystal Growth 368 (2013): 47-55. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875959261&partnerID=MN8TOARS.
    10.1016/j.jcrysgro.2013.01.016
  24. Martins, P.M.. "True and apparent inhibition of amyloid fibril formation". Prion 7 2 (2013): 136-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875436482&partnerID=MN8TOARS.
    10.4161/pri.23111
  25. Crespo, R.; Rocha, F.A.; Damas, A.M.; Martins, P.M.. "A generic crystallization-like model that describes the kinetics of amyloid fibril formation". Journal of Biological Chemistry 287 36 (2012): 30585-30594. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865710194&partnerID=MN8TOARS.
    10.1074/jbc.M112.375345
  26. Ferreira, C.; Rocha, F.A.; Damas, A.M.; Martins, P.M.. "Running away from thermodynamics to promote or inhibit crystal growth". Crystal Growth and Design 12 1 (2012): 40-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855367313&partnerID=MN8TOARS.
    10.1021/cg201354s
  27. Estevinho, B.N.; Damas, A.M.; Martins, P.; Rocha, F.. "Study of the inhibition effect on the microencapsulated enzyme ß-Galactosidase". Environmental Engineering and Management Journal 11 11 (2012): 1923-1930. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871676766&partnerID=MN8TOARS.
  28. Ferreira, C.; Crespo, R.; Martins, P.M.; Gales, L.; Rocha, F.; Damas, A.M.. "Small temperature oscillations promote protein crystallization". CrystEngComm 13 8 (2011): 3051-3056. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953168840&partnerID=MN8TOARS.
    10.1039/c0ce00550a
  29. Martins, P.M.; Rocha, F.; Damas, A.M.; Rein, P.. "Unsteady-state inhibition of crystal growth caused by solution impurities". CrystEngComm 13 4 (2011): 1103-1110. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551656012&partnerID=MN8TOARS.
    10.1039/c0ce00390e
  30. Crespo, R.; Martins, P.M.; Gales, L.; Rocha, F.; Damas, A.M.. "Potential use of ultrasound to promote protein crystallization". Journal of Applied Crystallography 43 6 (2010): 1419-1425. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649524231&partnerID=MN8TOARS.
    10.1107/S0021889810040951
  31. Martins, P.M.; Ferreira, A.; Polanco, S.; Rocha, F.; Damas, A.M.; Rein, P.. "Unsteady-state transfer of impurities during crystal growth of sucrose in sugarcane solutions". Journal of Crystal Growth 311 15 (2009): 3841-3848. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650376267&partnerID=MN8TOARS.
    10.1016/j.jcrysgro.2009.05.021
  32. Martins, P.M.; Rocha, F.A.. "Kinetic studies on the influence of temperature and growth rate history on crystal growth". Crystal Research and Technology 43 12 (2008): 1258-1267. http://www.scopus.com/inward/record.url?eid=2-s2.0-56749164345&partnerID=MN8TOARS.
    10.1002/crat.200800301
  33. Vasanth Kumar, K.; Martins, P.; Rocha, F.. "Modelling of the batch sucrose crystallization kinetics using artificial neural networks: Comparison with conventional regression analysis". Industrial and Engineering Chemistry Research 47 14 (2008): 4917-4923. http://www.scopus.com/inward/record.url?eid=2-s2.0-49249115556&partnerID=MN8TOARS.
    10.1021/ie701706v
  34. Martins, P.M.; Pessoa, J.; Sàrkàny, Z.; Rocha, F.; Damas, A.M.. "Rationalizing protein crystallization screenings through water equilibration theory and protein solubility data". Crystal Growth and Design 8 12 (2008): 4233-4243. http://www.scopus.com/inward/record.url?eid=2-s2.0-61549122663&partnerID=MN8TOARS.
    10.1021/cg8006958
  35. Martins, P.M.; Rocha, F.; Damas, A.M.. "Understanding water equilibration fundamentals as a step for rational protein crystallization". PLoS ONE 3 4 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-44349148425&partnerID=MN8TOARS.
    10.1371/journal.pone.0001998
  36. Martins, P.M.; Rocha, F.. "Characterization of crystal growth using a spiral nucleation model". Surface Science 601 16 (2007): 3400-3408. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547690705&partnerID=MN8TOARS.
    10.1016/j.susc.2007.06.016
  37. Martins, P.M.; Rocha, F.. "New developments on size-dependent growth applied to the crystallization of sucrose". Surface Science 601 23 (2007): 5466-5472. http://www.scopus.com/inward/record.url?eid=2-s2.0-36248974205&partnerID=MN8TOARS.
    10.1016/j.susc.2007.09.008
  38. Martins, P.M.; Rocha, F.. "A new theoretical approach to model crystal growth from solution". Chemical Engineering Science 61 17 (2006): 5696-5703. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745756984&partnerID=MN8TOARS.
    10.1016/j.ces.2006.04.037
  39. Martins, P.M.; Rocha, F.A.; Rein, P.. "The influence of impurities on the crystal growth kinetics according to a competitive adsorption model". Crystal Growth and Design 6 12 (2006): 2814-2821. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846166080&partnerID=MN8TOARS.
    10.1021/cg060448x
  40. Martins, P.M.; Rocha, F.. "The role of diffusional resistance on crystal growth: Interpretation of dissolution and growth rate data". Chemical Engineering Science 61 17 (2006): 5686-5695. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745759445&partnerID=MN8TOARS.
    10.1016/j.ces.2006.04.038
  41. Martins, P.M.; Rocha, F.A.; Rein, P.. "Modeling sucrose evaporative crystallization. Part 1. Vacuum pan monitoring by mass balance and image analysis methods". Industrial and Engineering Chemistry Research 44 23 (2005): 8858-8864. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444436213&partnerID=MN8TOARS.
    10.1021/ie050639h
  42. Martins, P.M.; Rocha, F.A.; Rein, P.. "Modeling sucrose evaporative crystallization. Part 2. Investigation into crystal growth kinetics and solubility". Industrial and Engineering Chemistry Research 44 23 (2005): 8865-8872. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444460360&partnerID=MN8TOARS.
    10.1021/ie050731d
Livro
  1. Martins, P.M.; Rocha, F.; Rein, P.. New methods for characterization and control of industrial crystallization. 2005.
Poster em conferência
  1. Saavedra, Joana; Sárkány, Zsuzsa; Cardoso, Isabel; Martins, Pedro. "Application of repurposed compounds as inhibitors of the non-amyloidogenic oligomerization of alpha-synuclein in Parkinson's Disease". Trabalho apresentado em 8th edition of the Molecular and Cell Biology Symposium - Let's have a moment of science!¿, 2022.
  2. Saavedra, Joana; Sárkány, Zsuzsa; Cardoso, Isabel; Martins, Pedro. "Drug repurposing compounds rescuing cell toxicity induced by soluble oligomers of alpha-synuclein". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN 2021), 2021.
  3. Silva, Alexandra; Figueiredo, Francisco; Almeida, Ana; Martins, Pedro; Macedo-Ribeiro, Sandra. "Dissecting the ataxin-3 aggregation pathway". Trabalho apresentado em 4th Symposium on Non-Globular Proteins, 2018.
Pré-impressão
  1. Raposo, Mafalda; Sárkány, Zsuzsa; Damásio, Joana; CRC-SCA Consortium; Lima, Manuela; Macedo-Ribeiro, Sandra; Martins, Pedro. "Effect of levodopa/carbidopa on the progression of Machado-Joseph disease /spinocerebellar ataxia type 3 (MJD/SCA3)". 2025.
  2. Sárkány, Zsuzsa; Damásio, Joana; Macedo-Ribeiro, Sandra; Martins, Pedro. "Association between the use of levodopa/carbidopa and the disease outcomes included in the National Alzheimer Coordinating Center Uniform Data Set". 2024.
  3. Zsuzsa Sárkány; Tiago Gião; Márcia Almeida Liz; Antoni Planas; Sandra Macedo-Ribeiro; Isabel Cardoso; Gemma Arsequell; Pedro M. Martins. "Transthyretin has conformation-selective proteolytic activity against a-synuclein". 2023. https://doi.org/10.1101/2023.08.10.552896.
    10.1101/2023.08.10.552896
  4. Francisco Figueiredo; Zsuzsa Sárkány; Alexandra Silva; Pedro M. Martins; Sandra Macedo Ribeiro. "Drug repurposing of dopaminergic drugs to inhibit Ataxin-3 aggregation". 2022. https://doi.org/10.1101/2022.12.01.518659.
    10.1101/2022.12.01.518659
  5. Zsuzsa Sárkány; Fernando Rocha; Anna Bratek-Skicki; Peter Tompa; Sandra Macedo-Ribeiro; Pedro M. Martins. "Quantification of surface tension effects and nucleation-and-growth rates during self-assembly of biological condensates". 2022. https://doi.org/10.1101/2022.11.23.517626.
    10.1101/2022.11.23.517626
Resumo em conferência
  1. Saavedra, Joana; Sárkány, Zsuzsa; Cardoso, Isabel; Martins, Pedro. "Preclinical development of small-molecule inhibitors of non-amyloidogenic aggregation of alpha-synuclein in Parkinson's Disease". Trabalho apresentado em International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders (AD/PD 2022), Barcelona, 2022.
    Publicado

Propriedade Intelectual

Pedido provisório de patente
  1. 2024. "Low-dose dopaminergic drugs to delay the progression of Spinocerebellar Ataxia Type 3 and Alzheimer’s Disease".
  2. 2024. "Compounds for use in the treatment of Machado-Joseph Disease through binding at a 'Dopamine docking site' in Ataxin 3.".
  3. 2020. "TREATMENT FOR SYNUCLEINOPATHIES USING INHIBITORS OF NON-AMYLOIDOGENIC ALPHA-SYNUCLEIN AGGREGATION".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/11/15 Sharp control of biological self-assembly via interfacial modulation of protein solubility 11th i3S Annual Meeting
2023/10/19 NAGPKin: A new web tool to quantify Nucleation-And-Growth Parameters from the KINetics of protein phase separation III PhasAGE International Conference
i3S (Porto, Portugal)
2023/10/17 BetterPharma - Drug repurposing in rare and prevalent neurodegenerative diseases PhasAGE BIOTECH WORKSHOP
i3S (Portugal)
2023/04/28 NAGpkin: a new web tool for seamless quantification of Nucleation-And-Growth KINetics of Protein phase separation Invited Talk
VUB Structural Biology Brussel (Brussel, Bélgica)
2022/09/12 Kinetic analysis of protein aggregation reactions Barcelona Protein Aggregation Training School
Universitat Autònoma de Barcelona (UAB) (Barcelona, Espanha)
2021/10/14 Surface tension effects on the nucleation-and-growth of phase separated proteins PhasAGE – Excellence Hub on Phase Transitions in Aging and Age-Related Disorders
Online Conference
2021/02 Non-amyloid hypotheses explored through chemical kinetic analysis 1st Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
1st Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics
2019/03 Modulation of Ataxin-3 Self-Assembly Pathway 1st Workshop on Strategies and Tools for Modulating Pathologic Protein Self-Assembly
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2018/09 From kinetic analysis to drug repurposing opportunities i3S Integrative Programs Seminars
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2015/10 What can the kinetics of amyloid fibril formation tell us about off-pathway aggregation? 1st NGP Symposium on Non-Globular Proteins
Instituto de Biologia Molecular e Celular (Porto, Portugal)
2015/09 In search of lost time constants and non-Michaelis-Menten parameters Beilstein ESCEC Symposium
Beilstein Institut (Rüdesheim, Alemanha)
2012/08 On growth rate hysteresis and catastrophic crystal growth 7th International Conference on Advanced Materials
International Organization for Crystal Growth (Brasov, Roménia)
2008/09 Modelling crystal growth from pure and impure solutions – a case study on sucrose International Symposium on Industrial Crystallization
European Federation of Chemical Engineering (Maastricht, Países Baixos)
2008/05 Water equilibration theory and protein solubility data used to rationalize crystallization screening 12th International Conference on the Crystallization of Biological Macromolecules
International Organization for Biological Crystallization (Cancun, México)
2007/09 Spiral nucleation model – Fundamentals and application to crystal growth results Bernal Symposium on Protein Crystallisation
British Association for Crystal Growth and Irish Association for Crystal Growth (Dublin, Irlanda)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2015/10 - 2020/02/12 New tools for enzymatic characterization and inhibitor screening: post-Michaelis-Menten kinetic analysis
Orientador de Maria F Pinto
 Biological sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2016/12 Advanced crystallization of biologically relevant molecules
Coorientador
 Chemical Engineering (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2012 - 2016/07/15 The Physics of the Phase Transition in Crystallogenesis and Amyloid Fibrillogenesis
Orientador de Rosa Crespo
 Chemical engineering (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2008 - 2010 Transfer of impurities into crystals in industrial processes : mechanics and kinetics
Coorientador
 Chemical Engineering (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2005 - 2019 Participated in several International Conferences and has been distinguished with best poster and best talk awards.
Conferência

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/03/17 Unraveling the role of liquid-liquid phase separation in prostate cancer and amyotrophic lateral sclerosis
Arguente principal
 Junaid Ahmed (Doutoramento)
2014/11/07 Fe/S cluster biogenesis regulation by the Janus-faced regulator, IscR: an unforeseen mechanism of DNA recognition and discrimination
Arguente
 Joana Abreu Luís da Silva Santos (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2009/10/01 - 2015/09/01 Teaching experience in Molecular Biophysics and Drug Design subjects (~300 hours per academic year) (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Tutoria

Tópico Nome do aluno
2011/04 - 2014/04 An alternative approach to 'hard-to-crystallize proteins Berta Estevinho
Distinções

Prémio

2023 The Brain Living Lab contest, RESOLVE-Health 2.0, an Acceleration Program
2012 Paper of the Week of Journal of Biological Chemistry with the paper " A generic Crystallization-Like Model that describes the kinetics of amyloid fibril formation". Distinction for the top 2 percent of manuscripts published by the journal during the year.
2008 Excellence Award in Crystallization 2008, a triennial Excellence Award acknowledging a PhD thesis or scientific publication which demonstrates the most outstanding contribution to research and/or practice in crystallization
European Federation of Chemical Engineering, Alemanha
2008 ICCBM12 Prize for best talk by Young Scientist
International Organization for Biological Crystallization, Alemanha
2006 Frank Chapman Memorial award
SUGAR INDUSTRY TECHNOLOGISTS, Estados Unidos
2006 Commisão Fulbright/Fundação Luso-Americana
Fundação Luso-Americana, Portugal

Fulbright Portugal, Portugal
2003 Short Term Research
Fundação Calouste Gulbenkian, Portugal
2000 Prémio José Magalhães Ramos
Rotary Club of Vila Nova de Gaia, Portugal
2000 Prémio Engº António de Almeida
Fundação Engenheiro António de Almeida, Portugal

Outra distinção

2023 BIP Acceleration (Finalist)
Universidade do Porto, Portugal
2015 Erasmus+ Program Mobility Grant
Universidade do Porto, Portugal
2014 Grant for Young Professors and Investigators 'Santander Universidades'
Banco Santander Totta, Portugal