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Ana Teresa Simões scientific path has been devoted to Neuroscience exploring calpain-mediated proteolysis in Machado Joseph Disease (MJD/SCA3), attempting to establish its potential as a biomarker and therapeutic target. This scientific challenge started with her PharmD graduation in Pharmaceutical Sciences in 2007, by the Faculty of Pharmacy (FFUC, Coimbra, Portugal), and went on beyond her PhD in Pharmaceutical Biotechnology by FFUC in 2012, followed by a six-year postdoctoral training at the Center for Neuroscience and Cell Biology (Coimbra, PT), funded by FCT (PT), where she established a new pathogenic mechanism in MJD/SCA3 based on the formation of toxic fragments of ataxin-3 related to calcium dysregulation. Her main goal was to develop a successful therapeutic strategy for MJD using three different approaches: pharmacological, gene therapy, and genome editing. During this period, she graduated in Medicine (Faculty of Medicine, UC, 2018) and moved on to clinical practice at the Coimbra Hospital and Universitary Center (CHUC, Coimbra, 2019/---), now gathering unique skills combining clinical to basic to translational research. She has a h-index of 7, resulting from 7 co-authored publications in high impact peer-reviewed journals and 1 book chapter, cited over 205 times (WoS), and 4 publications in Conference Proceedings. She has also co-authored 24 oral communications and 19 poster presentations in national and international scientific meetings. Her academic and scientific performances were distinguished by the Lusitana Pharmaceutical Society award (2007), the Portuguese Soc for Neuroscience (2 best papers, 2013-2014), and the National Ataxia Foundation (NAF, travel stipend to attend the 5th Ataxia Investigators Meeting in Las Vegas, US – 2014), and was selected for oral communications in the most relevant conferences in the area, such as the Annual Meeting of the Society for Neuroscience (US, 2009), and the Ataxia Research Conference (UK, 2015). Ana Teresa Simões participated in 16 national and international R&D projects, funded by FCT (PT), NAF (US) and AFM (FR) and succeeded as an independent researcher, attested by the NAF award (15'000 USD) and funds from the Blade Therapeutics to study calpain-mediated proteolysis in MJD. She was invited to give 10 lectures in graduate and postgraduate courses (2010-2019) and also gave practical classes to Pharmaceutical Sciences Master’s degree, supervised 2 Master students (2013/15, 2017/18) and provided scientific guidance for up to 7 PhD, MSc and under-graduated students (2009-2017), and also participated as jury arguer of a PhD thesis (2017). Additionally, she regularly participates in BAW, Science and Technology Week and Open Lab Days promoting scientific knowledge and practices.
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Identificação

Identificação pessoal

Nome completo
Ana Teresa Antunes Simões

Nomes de citação

  • Simões, AT
  • Simões, Ana T.

Identificadores de autor

Ciência ID
E715-7062-B946
ORCID iD
0000-0003-3305-485X
Google Scholar ID
https://scholar.google.pt/citations?user=l86smZ0AAAAJ&hl=en
Researcher Id
L-3153-2014
Scopus Author Id
55329689100

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Médicas e da Saúde - Medicina Clínica
  • Ciências Médicas e da Saúde - Biotecnologia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2016/06/01 - 2018/12/31
Concluído
 The pathogenic relationship between calcium levels deregulation and calpain-mediated proteolysis in Machado-Joseph disease” (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/07/27
Concluído
 Integrated Master's degree in Medicine (Mestrado integrado)
Especialização em Medicine
Universidade de Coimbra Faculdade de Medicina, Portugal
"Identification of the toxic fragment of ataxin-3 protein in Machado-Joseph disease [in Neurology: 20 (out of 20)]" (TESE/DISSERTAÇÃO)
 16 (out of 20)
2013/02/01 - 2016/05/31
Concluído
 Calpain-mediated proteolysis in Machado-Joseph disease: biomarker and therapeutic target (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/07/27
Concluído
 Pharmaceutical Sciences (Doutoramento)
Especialização em Specialty field of Pharmaceutical Biotechnology
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease." (TESE/DISSERTAÇÃO)
 Unanimous Distinction and Honors
2007/07/24
Concluído
 Pharmaceutical Sciences (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 17 (out of 20)
2002/12
Concluído
 Certificate of Proficiency in English (Outros)
University of Cambridge, Reino Unido
1998/09
Concluído
 Diplôme Pratique de Langue Française (French Language Certificate) (Outros)
Fondation Alliance Française, França
1998/07
Concluído
 Zertifikat Deutsch als Fremdsprache (German Foreign Language Certificate) (Outros)
Goethe-Institut, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/01 - 2018/12/31 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
CNC.IBILI, Portugal
2013/02/01 - 2014/12/31 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/10/01 - 2012/08/31 Estagiário de Investigação (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/10/01 - 2011/09/30 Estagiário de Investigação (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/04/02 - 2007/06/28 Estagiário de Investigação (Investigação) ERASMUS Scientific Research Internship, Bélgica
University Catholique de Louvain Louvain Drug Research Institute, Bélgica
2006/12/11 - 2007/01/05 Estagiário de Investigação (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outras Carreiras

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/01/01 - Atual Interno (Médica) Hospitais da Universidade de Coimbra, Portugal
Hospitais da Universidade de Coimbra, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/01/15 - 2007/03/15 Extra-curricular Academic Internship Coimbra Hospital and University Centre - Pediatric Hospital - Pharmaceutical Services, Portugal
2006/09/04 - 2006/12/09 Extra-curricular Academic Internship Community pharmacy: Farmácia Luciano & Matos, Portugal
2005/11/23 - 2006/04/13 Extra-curricular Academic Internship Universidade de Coimbra Faculdade de Farmácia Laboratório de Análises Clínicas, Portugal
2004/09/01 - 2004/09/30 Extra-curricular Academic Internship Coimbra Hospital and University Centre - Pharmaceutical Services, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - 2019 Calpain inhibition as a therapeutic strategy in Machado-Joseph disease.
Calpain Targeted Inhibition
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Blade Therapeutics
Concluído
2017/01 - 2017/12 Calpain-mediated proteolysis in Machado-Joseph disease.
Seed Money Grant 2017
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 National Ataxia Foundation
Concluído
2013/03 - 2016/02 Towards the Understanding of Pathological Protein Processing and Toxicity in Machado-Joseph Disease.
E-Rare4/0003/2012
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 European Research Area Board
Concluído
2013 - 2016 Caffeine alleviation of MJD/SCA3
2013 41(1)
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 National Ataxia Foundation
Concluído
2010/02 - 2013/04 The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors
99307
Provided by PTCRIS: 99307
 Fundação para a Ciência e a Tecnologia, I.P.
2010/12 - 2012/12 Role of the autophagy-related protein Beclin-1 in Machado-Joseph disease.
SB/NF/2010/2008 Number 15079CA
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 AFM-Téléthon
Concluído
2011/04 - 2012/08 Cell to Cell Transport of Alpha-synuclein in Parkinson's Disease. The Progression Factor?
PTDC/SAU-NMC/109955/2009
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2018/07/01 - 2021/06/30 Blocking neurodegeneration by spreading of gene silencers
PTDC/BTM-SAL/29716/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Prediger, R.D.; Hirai, H.; Cunha, R.A.; Pereira de Almeida, Luis Fernando Morgado. "Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia". Annals of Neurology 81 3 (2017): 407-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013441188&partnerID=MN8TOARS.
    Publicado • 10.1002/ana.24867
  2. Carmona, Vitor; Cunha-Santos, Janete; Onofre, Isabel; Simões, Ana Teresa Antunes (E715-7062-B946); Vijayakumar, U.; Davidson, B.L.; Pereira de Almeida, Luis Fernando Morgado. "Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease". Molecular Therapy 25 4 (2017): 1038-1055. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016966764&partnerID=MN8TOARS.
    Publicado • 10.1016/j.ymthe.2017.01.021
  3. Simões, Ana; Machado, Nuno J.; Gonçalves, Nélio; Kaster, Manuella; Simões, Ana Teresa Antunes (E715-7062-B946); Nunes, A.; Pereira de Almeida, Luis Fernando Morgado; et al. "Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory". Neuropsychopharmacology 41 12 (2016): 2862-2871. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978777019&partnerID=MN8TOARS.
    Publicado • 10.1038/npp.2016.98
  4. Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa Antunes (E715-7062-B946); den Dunnen, W.F.A.; Hirai, H.; Kügler, Sebastian; Cavadas, Claudia; Pereira de Almeida, Luis Fernando Morgado. "Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease". Human Molecular Genetics 24 19 (2015): 5451-5463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943793236&partnerID=MN8TOARS.
    Publicado • 10.1093/hmg/ddv271
  5. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Nobre, R.J.; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of machado-Joseph disease". Human Molecular Genetics 23 18 (2014): 4932-4944. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906821927&partnerID=MN8TOARS.
    10.1093/hmg/ddu209
  6. Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, R. A.; Pereira de Almeida, Luis Fernando Morgado. "Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease". Annals of Neurology 73 5 (2013): 655-666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878306815&partnerID=MN8TOARS.
    Publicado • 10.1002/ana.23866
  7. Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Koeppen, A.; Deglon, Nicole; Kugler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease". Brain 135 8 (2012): 2428-2439. http://dx.doi.org/10.1093/brain/aws177.
    Publicado • 10.1093/brain/aws177
Capítulo de livro
  1. Nóbrega, Clévio; Simões, Ana Teresa Antunes (E715-7062-B946); Duarte-Neves, Joana; Duarte, Sara; Vasconcelos-Ferreira, Ana Cristina; Cunha-Santos, Janete; Pereira, Dina; et al. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis.". In Advances in experimental medicine and biology, 349-367. 2018.
    Publicado • 10.1007/978-3-319-71779-1_18
Poster em conferência
  1. Gonçalves, Nélio; Machado, Nuno J.; Souza, Carolina M.; Fernandes, Sara B.; Simões, Ana; Simões, Ana; Pereira de Almeida, Luis Fernando Morgado; Cunha, R. A.. "Selective amygdala neuronal down-regulation of adenosine A2A receptors prevents mood-related modifications". Trabalho apresentado em The 7th International Society of Neurochemistry Conference: Synaptic function and dysfunction in brain diseases, 2016.
  2. Simões, Ana; Machado, Nuno J.; Gonçalves, Nélio; Kaster, Manuella; Simões, Ana; Nunes, Ana; Pereira de Almeida, Luis Fernando Morgado; et al. "Adenosine A2A receptors in the amygdala control synaptic plasticity and fear memory". Trabalho apresentado em The 7th International Society of Neurochemistry Conference: Synaptic function and dysfunction in brain diseases, 2016.
  3. Carmona, Vitor; Cunha-Santos, Janete; Simões, Ana; Pereira de Almeida, Luis Fernando Morgado. "Ataxin-3 3’UTR reduces neuropathology in a lentiviral mouse model of Machado-Joseph disease – a role for microRNAs?". Trabalho apresentado em EMBO workshop: Modern DNA concepts and tools for safe gene transfer and modification, 2015.
  4. Gonçalves, Nélio; Simões, Ana; Prediger, R.D.; Cunha, R.A.; Pereira de Almeida, Luis Fernando Morgado. "Caffeine alleviates progressive motor deficits in Machado-Joseph disease transgenic mice". Trabalho apresentado em Ataxia Research Conference 2015, 2015.
  5. Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana; den Dunnen, W.F.A.; Cavadas, Claudia; Pereira de Almeida, Luis Fernando Morgado. "Therapeutic role of neuropeptide Y in mouse models of Machado-Joseph disease". Trabalho apresentado em XII Annual Meeting of the Center for Neuroscience and Cell Biology, 2014.
  6. Carmona, Vitor; Cunha-Santos, Janete; Simões, Ana; Pereira de Almeida, Luis Fernando Morgado. "Ataxin-3 3’UTR reduces neuropathology in a lentiviral mouse model of Machado-Joseph disease – a role for microRNAs ?". Trabalho apresentado em XII Annual Meeting of the Center for Neuroscience and Cell Biology, 2014.
  7. Simões, Ana; Gonçalves, Nélio; Nobre, Rui Jorege; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em NAF – National Ataxia Foundation – 5th Ataxia Investigators Meeting, 2014.
  8. Simões, Ana; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em CAG Triplet repeat disorders, Gordon Research Conferences, 2013.
  9. Simões, Ana; Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em XIII Annual Meeting of the Portuguese Society for Neuroscience, 2013.
  10. Simões, Ana; Gonçalves, Nélio; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpain-mediated proteolysis promotes mutant ataxin-3 translocation to the nucleus and neurodegeneration". Trabalho apresentado em The biology of calpains in health and disease, 2010.
  11. Simões, Ana; Gonçalves, Nélio; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpain-mediated proteolysis promotes mutant ataxin-3 translocation to the nucleus and neurodegeneration". Trabalho apresentado em Science 2010 – Meeting with Science and Technology in Portugal, 2010.
  12. Gonçalves, Nélio; Simões, Ana; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Antagonism of adenosine A2A receptors delays neurodegeneration in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em Purines 2010, Adenine Nucleosides and Nucleotides in Biomedicine, 2010.
  13. Simões, Ana; Gonçalves, Nélio; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Calpains promote mutant ataxin-3 translocation to the nucleus and neurodegeneration". Trabalho apresentado em Neuroscience 2009, 39th Annual Meeting of the Society for Neuroscience, 2009.
  14. Gonçalves, Nélio; Simões, Ana; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Antagonism of adenosine A2A receptors provides neuroprotection in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em Neuroscience 2009, 39th Annual Meeting of the Society for Neuroscience, 2009.
  15. Simões, Ana; Gonçalves, Nélio; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of mutant ataxin-3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience, 2009.
  16. Gonçalves, Nélio; Simões, Ana; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Blockade of adenosine receptors by caffeine provides neuroprotection in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience, 2009.
  17. Simões, Ana; Gonçalves, Nélio; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of calpains prevents translocation of mutant ataxin-3 to the nucleus and reduces neurodegeneration in a lentiviral mouse model of Machado-Joseph Disease". Trabalho apresentado em IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009.
  18. Gonçalves, Nélio; Simões, Ana; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Adenosine A2A receptors antagonism delays neurodegeneration in a lentiviral mouse model of Machado-Joseph disease". Trabalho apresentado em IV Meeting on the Molecular Mechanisms of Neurodegeneration, 2009.
  19. Simões, Ana; Nóbrega, Clévio; Déglon, Nicole; Duarte, Carlos B.; Kügler, Sebastian; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of calpains in a lentiviral mouse model of Machado-Joseph Disease". Trabalho apresentado em Lentiviral vectors: concepts, practice, hope and reality, 2008.
Resumo em conferência
  1. Duarte-Neves, Joana; Cunha-Santos, Janete; Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); den Dunnen, Wilfred F.A.; Hirai, Hirokazu; Kügler, Sebastian; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y alleviates Machado–Joseph disease". Trabalho apresentado em Advances in NPY Research, 2016.
    Publicado • 10.1016/j.npep.2015.11.013
  2. Gonçalves, Nélio; Simões, Ana; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Antagonism of Adenosine A2A Receptors Delays Neurodegeneration in a Lentiviral Mouse Model of Machado-Joseph Disease". Trabalho apresentado em Purines 2010: Adenine Nucleosides and Nucleotides in Biomedicine, Tarragona, 2010.
    Publicado • 10.1007/s11302-010-9187-6
  3. Simões, AT; Gonçalves, Nélio; Nóbrega, Clévio; Déglon, Nicole; Duarte, Carlos B.; Kügler, Sebastian; Pereira de Almeida, Luis Fernando Morgado. "Inhibition of Mutant Ataxin-3 Proteolysis by Calpains in a Lentiviral Mouse Model of Machado-Joseph Disease". Trabalho apresentado em V International Workshop on MJD, São Miguel, Azores, 2009.
    Publicado • 10.3389/conf.neuro.01.2009.11.100
  4. Gonçalves, Nélio; Simões, AT; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado. "Blockade of adenosine receptors by caffeine provides neuroprotection in a lentiviral mouse model of Machado-Joseph Disease". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience, Braga, 2009.
    Publicado • 10.3389/conf.neuro.01.2009.11.105
Tese / Dissertação
  1. Simões, Ana Teresa Antunes. "Identification of the toxic fragment of ataxin-3 protein in Machado-Joseph disease". Mestrado, Universidade de Coimbra Faculdade de Medicina, 2018. http://hdl.handle.net/10316/81993.
  2. Simões, Ana Teresa. "Calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease". Doutoramento, Universidade de Coimbra Faculdade de Farmácia, 2012. http://hdl.handle.net/10316/20543.

Outros

Norma técnica
  1. FELASA CAtegory B certified researcher. Certified researcher for Carrying out Animal Experiments by Direção Geral de Alimentação e Veterinária (DGAV), Ministério da Agricultura e do Mar, Portugal. 2015. Simões, Ana.
Técnica de investigação
  1. Certification for Stereological Applications in Experimental Pathology and Regenerative Medicine by the Faculty of Medicine, University of Coimbra & Portuguese Association for Experimental Pathology, Portugal (2008). Investigador. Simões, Ana.
    Investigador
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2017/09/27 Role of microRNAs in Machado-Joseph disease: from pathogenesis to therapy 2017 International Ataxia Research Conference
EuroAtaxia (Pisa, Itália)
2017/02/02 Identification of the calpain cleavage sites in ataxin-3 protein XLVII Annual Meeting - SPF 2017
Portuguese Pharmacological Society (Coimbra, Portugal)
2017/02/02 The role of microRNAs in Machado-Joseph disease: from pathogenesis to therapy XLVII Annual Meeting - SPF 2017
Portuguese Pharmacological Society (Coimbra, Portugal)
2017/02/02 Selective down-regulation of amygdala neuronal A2A receptors prevents behavioural modifications induced by stress XLVII Annual Meeting - SPF 2017
Portuguese Pharmacological Society (Coimbra, Portugal)
2016/11/18 MicroRNAs control mutant ataxin-3 expression through 3'UTR mediated regulation Brain With]Out[Borders
Universidade de Coimbra (Coimbra, Portugal)
2016/02/04 Post-transcriptional regulation of ataxin-3 – A role for microRNAs XLVI Annual Meeting - SPF 2016
Portuguese Pharmacological Society (Porto, Portugal)
2015/12/17 Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph Disease XIII Annual Meeting - 2015
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2015/06/04 The triad of behavioural modifications characteristic of depression is abrogated by the selective amygdala neuronal down-regulation of adenosine A2A receptors XIV Meeting - SPN 2015
Portuguese Society for Neuroscience (Póvoa de Varzim, Portugal)
2015/03/30 Ataxin-3 3’UTR reduces neuropathology in a lentiviral mouse model of Machado-Joseph disease – a role for microRNAs? EMBO workshop: Modern DNA concepts and tools for safe gene transfer and modification
EMBO (Paris, França)
2015/03/25 Identification of the calpain cleavage sites in ataxin-3 protein Ataxia Research Conference 2015
Ataxia UK (Old Windsor, England, Reino Unido)
2015/03/25 Therapeutic role of neuropeptide Y in mouse models of Machado-Joseph disease Ataxia Research Conference 2015
Ataxia UK (Old Windsor, England, Reino Unido)
2015/02/04 Neuropeptide Y alleviates neuropathological and behavioral abnormalities in mice models of Machado-Joseph Disease XLV Annual Meeting - SPF 2015
Portuguese Pharmacological Society (Lisbon, Portugal)
2014/03/18 Caffeine alleviates progressive motor deficits in MJD transgenic mice 5th Ataxia Investigators Meeting - 2014
NAF – National Ataxia Foundation (Las Vegas, Nevada, Estados Unidos)
2014/02/05 Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease XLIV Annual Meeting - SPF 2014
Portuguese Pharmacological Society (Coimbra, Portugal)
2014/02/05 Neuropeptide Y neuroprotective role in a lentiviral model of Machado-Joseph Disease XLIV Annual Meeting - SPF 2014
Portuguese Pharmacological Society (Coimbra, Portugal)
2013/11/09 Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease Neuroscience 2013, 43th Annual Meeting
Society for Neuroscience (San Diego, California, Estados Unidos)
2013/05/30 Orally-administered calpain inhibitor BDA-410 reduces ataxin-3 cleavage and alleviates neuropathology in a lentiviral mouse model of Machado-Joseph disease XIII Annual Meeting - SPN 2013
Portuguese Society for Neurosciences (Luso, Portugal)
2011/02/02 Calpains cleave mutant ataxin-3 promoting Machado-Joseph Disease XLI Annual Meeting - SPF 2011
Portuguese Pharmacological Society (Coimbra, Portugal)
2011/02/02 Pharmacological antagonism or genetic deletion of adenosine A2A receptors delay neurodegeneration in a lentiviral mouse model of Machado-Joseph disease XLI Annual Meeting - SPF 2011
Portuguese Pharmacological Society (Coimbra, Portugal)
2010/12/20 Calpain-mediated proteolysis promotes mutant ataxin-3 translocation to the nucleus and neurodegeneration VIII Annual Meeting - 2010
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2010/12/20 Pharmacological antagonism or genetic deletion of adenosine A2A receptors delay neurodegeneration in a lentiviral mouse model of Machado-Joseph disease VIII Annual Meeting - 2010
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2009/04/01 Inhibition of calpains in a lentiviral mouse model of MJD prevents nuclear localization and reduces neuronal dysfunction and degeneration. V International Workshop on MJD
(São Miguel, Azores, Portugal)
2009/04/01 Gene transfer approach for the study of the adenosine A2A receptors role in Machado-Joseph disease V International Workshop on MJD
(São Miguel, Azores, Portugal)
2008/12/16 Gene transfer approach for the study of the adenosine A2A receptors role in Machado-Joseph disease VI Annual Meeting - 2008
Center for Neuroscience and Cell Biology (Coimbra, Portugal)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2009 - 2018 Brain Awareness Weeks; yearly organized by CNC sponsored by SPN, Ciência Viva Agency, FENS and the Dana Foundation. "Open Laboratories" are organized in close collaboration with School clusters, the Science Museum, Science Center and local City Council.
Encontro
 Brain Awareness Weeks
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - 2018 Open Lab activities for teenager and young adult audiences; receiving high school and undergraduated students in the laboratory.
Oficina (workshop)
 Open Lab Days
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 - 2018 Science and Technology weeks
Encontro
 Science and Technology weeks
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2017/05/02 MicroRNAs targeting Ataxin-3 mRNA in Machado-Joseph disease: from pathogenesis to therapy.
Arguente
 Vitor Manuel Martins Carmona (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019/04/06 - 2019/04/06 Molecular Mechanisms of Diseases and Biological Models Master's in Pharmaceutical Biotechnology (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/05/07 - 2018/05/11 Advanced Therapies 2018 Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/04/14 - 2018/04/14 Molecular Mechanisms of the Diseases and Biological Models Master's degree in Pharmaceutical Biotechnology (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/03/25 - 2017/03/25 Molecular Therapeutics and Tissue Engineering Master's degree in Pharmaceutical Biotechnology (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/06/13 - 2016/06/17 Advanced Therapies 2016 Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/01/30 - 2012/02/03 Gene and Cell Therapy of CNS: from microRNAs to IPS cells Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/09/26 - 2011/09/30 Research Methods and Techniques Doctoral Programme in Health Sciences (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/11/01 - 2010/11/05 Molecular Mechanisms of Disease Doctoral Programme in Health Sciences (PhDHS) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/10/25 - 2010/10/29 Recombinant DNA Technology Master's degree in Pharmaceutical Biotechnology (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/04 - 2010/10/08 Research Methods and Techniques Doctoral Programme in Health Science (PhDHS) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2010 Pharmaceutical Technology practical classes Pharmaceutical Sciences (Mestrado integrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
Distinções

Prémio

2014 Best paper award in Neurobiology of Diseases - 2014
Portuguese Society for Neuroscience, Portugal
2013 Best Paper Award in Neurobiology of Diseases - 2013
Portuguese Society for Neuroscience, Portugal
2007 Lusitana Pharmaceutical Society
Ordem dos Farmaceuticos, Portugal
2006 Merit Scholarship
Universidade de Coimbra, Portugal
2006 3% best students of each Bachelor Course
Universidade de Coimbra, Portugal
2005 Merit Scholarship
Universidade de Coimbra, Portugal
2005 3% best students of each Bachelor Course
Universidade de Coimbra, Portugal
2004 Merit Scholarship
Universidade de Coimbra, Portugal
2003 Merit Scholarship
Universidade de Coimbra, Portugal

Outra distinção

2014 Travel stipend to attend 5th Ataxia Investigators Meeting in Las Vegas, USA
National Ataxia Foundation, Estados Unidos
2009 Travel stipend to attend Neuroscience 2009, Society for Neuroscience in Chicago, USA
Sociedade Portuguesa de Bioquímica, Portugal