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Margarida Saraiva obtained a degree in Biochemistry (Hons) in 1997, by Faculdade de Ciências da Universidade do Porto, Portugal. After 4 years (1999-2002) of research on Poxvirus Immune Evasion, in Antonio Alcami's lab, Margarida Saraiva obtained a PhD in Pathology awarded by the University of Cambridge, UK, and moved to Anne O'Garra's lab, at the MRC-National Institute for Medical Research (London). During her post-doc, Margarida Saraiva investigated the molecular mechanisms that regulate the expression of Interleukin-10 by immune cells. In 2007, Margarida Saraiva returned to Portugal and joined the Life and Health Sciences Research Institute (ICVS) at Universidade do Minho, as a Ciência 2007 fellow, to study several cellular and molecular mechanisms in place during the innate immune response to mycobacteria. From June 2015, Margarida Saraiva became a group leader at IBMC-Porto to study the molecular mechanisms underlying immune regulation using deregulated myelopoiesis and tuberculosis as disease models. Margarida Saraiva has published over 70 articles in peer-reviewed journals, gathering over 5200 citations; successfully supervised several MSc, PhD and Post-doctoral fellows; has been PI in several competitive funded grants; has been invited speaker in various international conferences and institutes; and has been awarded several national and international prizes for her research. Margarida Saraiva served as President of the Portuguese Society for Immunology between 2018-2021.
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Identificação

Identificação pessoal

Nome completo
Margarida Saraiva

Nomes de citação

  • Saraiva, Margarida

Identificadores de autor

Ciência ID
E913-D1B0-CEB1
ORCID iD
0000-0002-8180-1293
Scopus Author Id
35079223500

Endereços de correio eletrónico

  • margarida.saraiva@ibmc.up.pt (Profissional)

Moradas

  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês (Idioma materno)
Formação
Grau Classificação
2003
Concluído
 Doutoramento em Patologia (Doutoramento)
University of Cambridge Murray Edwards College, Reino Unido
"Immunomodulatory molecules encoded by poxviruses- TNF receptor homologues." (TESE/DISSERTAÇÃO)
 aprovado por unanimidade
1997
Concluído
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 17
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/06/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/05/01 - 2015/05/30 Investigador principal (carreira) (Investigação) Universidade do Minho, Portugal
Laboratório Associado ICVS 3B's, Portugal
2007/04/01 - 2013/04/30 Investigador Auxiliar (carreira) (Investigação) Universidade do Minho, Portugal
Laboratório Associado ICVS 3B's, Portugal
2006/01/03 - 2007/03/31 Investigador Auxiliar Convidado (carreira) (Investigação) National Institute for Medical Research, Reino Unido
2003/01/03 - 2005/12/31 Pós-doutorado (Investigação) National Institute for Medical Research, Reino Unido
1997/09/01 - 1998/12/31 Estagiário de Investigação (Investigação) Universidade do Porto, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projetos

Bolsa

Designação Financiadores
2021/03/01 - Atual Host-microbiome interactions in the quest for Fibrosing ILD Biomarkers that Rule Acceleration (FIBRA-Lung)
PTDC/MEC-RES/0158/2020
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2024/12/31 Deciphering the immune mechanisms of tuberculosis disease severity through host-pathogen interactions
PTDC/SAU-INF/1172/2021
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/09/15 - 2024/08/15 A multidisciplinary approach to understand host and pathogen interactions to develop new strategies to target TB
HR21-00415
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 La Caixa Research Foundation
Em curso
2018/08/27 - 2021/08/26 Understanding host-pathogen interactions in tuberculosis: lessons from Mycobacterium africanum.
Maf_TB
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia

Aga Khan Foundation
Em curso
2018/06/01 - 2021/05/31 Molecular stratification of latent tuberculosis: a persisting memory?
POCI-01-0145-FEDER-028955
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2014/09/01 - 2017/04/01 Deregulation of hematopoiesis by IL-10: implications for the development of hematologic diseases
FCT-ANR/BIM-MEC/0007/2013
Investigador responsável
Laboratório Associado ICVS 3B's, Portugal

Institut Pasteur, França
Concluído
2010/03/01 - 2013/02/28 Molecular mechanisms underlying regulation of IL-12 family of cytokines expression on macrophages and dendritic cells infected by Mycobacterium tuberculosis
PTDC- BIA-BCM/102776/2008
Investigador responsável
Laboratório Associado ICVS 3B's, Portugal
Concluído

Projeto

Designação Financiadores
2019/03/01 - 2025/02/28 Deciphering host-pathogen interactions to understand tuberculosis
CEECIND/00241/2017
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Em curso
2021/03/01 - 2024/02/29 Interações hospedeiro-microbioma na busca por biomarcadores de doenças pulmonares intersticiais fibrosantes que regem a aceleração FIBRA-Lung<br>
PTDC/MEC-RES/0158/2020
Centro Hospitalar Universitário de São João, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Maceiras, Ana Raquel; Silvério, Diogo; Gonçalves, Rute; Cardoso, Marcos S.; Saraiva, Margarida. "Infection with hypervirulent Mycobacterium tuberculosis triggers emergency myelopoiesis but not trained immunity". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1211404.
    10.3389/fimmu.2023.1211404
  2. Couto, Joana; Gonçalves, Rute; Lamas, Sofia; Saraiva, Margarida. "Protocol for infecting and monitoring susceptible k18-hACE2 mice with SARS-CoV-2". STAR Protocols 4 2 (2023): 102303. http://dx.doi.org/10.1016/j.xpro.2023.102303.
    10.1016/j.xpro.2023.102303
  3. Gomes, Ana Cordeiro; Sousa, Daniela Monteiro; Oliveira, Tiago Carvalho; Fonseca, Óscar; Pinto, Ricardo J.; Silvério, Diogo; Fernandes, Ana Isabel; et al. "Serum amyloid A proteins reduce bone mass during mycobacterial infections". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1168607.
    10.3389/fimmu.2023.1168607
  4. Saraiva, Maria João; Moreira, João; Martins, Helena; Saraiva, Margarida. "TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with downregulated expression of chemokines". Clinical Science (2023): http://dx.doi.org/10.1042/cs20220656.
    10.1042/cs20220656
  5. Gonçalves, Rute; Couto, Joana; Ferreirinha, Pedro; Costa, José Maria; Silvério, Diogo; Silva, Marta L.; Fernandes, Ana Isabel; et al. "SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice". iScience 26 2 (2023): 105972. http://dx.doi.org/10.1016/j.isci.2023.105972.
    10.1016/j.isci.2023.105972
  6. Marta L. Silva; Antje Blumenthal; Baltazar Cá; Nuno S. Osório; Pedro N. S. Rodrigues; Ana Raquel Maceiras; Margarida Saraiva. "Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns". PLOS Pathogens (2022): https://doi.org/10.1371/journal.ppat.1010490.
    10.1371/journal.ppat.1010490
  7. Diogo Silvério; Rute Gonçalves; Rui Appelberg; Margarida Saraiva; Murugesan V. S. Rajaram; Jacob Yount. "Advances on the Role and Applications of Interleukin-1 in Tuberculosis". mBio 12 6 (2021): https://doi.org/10.1128/mBio.03134-21.
    10.1128/mBio.03134-21
  8. Rocha, Deisy M. G. C.; Viveiros, Miguel; Saraiva, Margarida; Osório, Nuno S.. "The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem". Genes 12 12 (2021): 2003. http://dx.doi.org/10.3390/genes12122003.
    10.3390/genes12122003
  9. Cardoso, Ana; Martins, Ana Catarina; Maceiras, Ana Raquel; Liu, Wei; Castro, Isabel; Castro, António G.; Bandeira, António; et al. "Interleukin-10 induces interferon-¿-dependent emergency myelopoiesis". Cell Reports 37 4 (2021): 109887. http://dx.doi.org/10.1016/j.celrep.2021.109887.
    10.1016/j.celrep.2021.109887
  10. Rocha, Deisy M. G. C.; Magalhães, Carlos; Cá, Baltazar; Ramos, Angelica; Carvalho, Teresa; Comas, Iñaki; Guimarães, João Tiago; et al. "Heterogeneous Streptomycin Resistance Level Among Mycobacterium tuberculosis Strains From the Same Transmission Cluster". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.659545.
    10.3389/fmicb.2021.659545
  11. Moreira, João; Costelha, Susete; Saraiva, Margarida; Saraiva, Maria João. "The Expression of Chemokines Is Downregulated in a Pre-Clinical Model of TTR V30M Amyloidosis". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.650269.
    10.3389/fimmu.2021.650269
  12. Matos, Rita; Fonseca, Kaori L.; Mereiter, Stefan; Maceiras, Ana Raquel; Gomes, Joana; Vilaplana, Cristina; Gartner, Fátima; et al. "Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium". Microorganisms 9 1 (2021): 99. http://dx.doi.org/10.3390/microorganisms9010099.
    Publicado • 10.3390/microorganisms9010099
  13. Moreira-Teixeira, Lúcia; Stimpson, Philippa J.; Stavropoulos, Evangelos; Hadebe, Sabelo; Chakravarty, Probir; Ioannou, Marianna; Aramburu, Iker Valle; et al. "Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-19412-6.
    Acesso aberto • Publicado • 10.1038/s41467-020-19412-6
  14. Jeremy Sousa; Baltazar Cá; Ana Raquel Maceiras; Luisa Simões-Costa; Kaori L. Fonseca; Ana Isabel Fernandes; Angélica Ramos; et al. "Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production". Nature Communications 11 (2020): 1949. https://www.nature.com/articles/s41467-020-15832-6.pdf.
    No prelo • 10.1038/s41467-020-15832-6
  15. Moreira-Teixeira, Lúcia; Tabone, Olivier; Graham, Christine M.; Singhania, Akul; Stavropoulos, Evangelos; Redford, Paul S.; Chakravarty, Probir; et al. "Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis". Nature Immunology 21 4 (2020): 464-476. http://dx.doi.org/10.1038/s41590-020-0610-z.
    Publicado • 10.1038/s41590-020-0610-z
  16. Fonseca, Kaori L.; Maceiras, Ana Raquel; Matos, Rita; Simoes-Costa, Luisa; Sousa, Jeremy; Cá, Baltazar; Barros, Leandro; et al. "Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils". Mucosal Immunology (2020): http://dx.doi.org/10.1038/s41385-020-0277-7.
    Acesso aberto • Publicado • 10.1038/s41385-020-0277-7
  17. Mariana Resende; Catarina M. Ferreira; Ana Margarida Barbosa; Marcos S. Cardoso; Jeremy Sousa; Margarida Saraiva; António G. Castro; Rui Appelberg; Egídio Torrado. "Myeloid HIF-1a regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection". Immunology (2020): https://doi.org/10.1111/imm.13131.
    10.1111/imm.13131
  18. Saraiva, Margarida; Vieira, Paulo; O’Garra, Anne. "Biology and therapeutic potential of interleukin-10". The Journal of Experimental Medicine 217 1 (2019): http://dx.doi.org/10.1084/jem.20190418.
    10.1084/jem.20190418
  19. Dorhoi A; Glaría E; Garcia-Tellez T; Nieuwenhuizen NE; Zelinskyy G; Favier B; Singh A; et al. "MDSCs in infectious diseases: regulation, roles, and readjustment.". Cancer immunology, immunotherapy : CII (2018): http://europepmc.org/abstract/med/30569204.
    10.1007/s00262-018-2277-y
  20. Sousa J; Saraiva M. "Paradigm changing evidence that alter tuberculosis perception and detection: Focus on latency.". Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2018): http://europepmc.org/abstract/med/30576838.
    10.1016/j.meegid.2018.12.019
  21. Bhatt K; Machado H; Osório NS; Sousa J; Cardoso F; Magalhães C; Chen B; et al. "A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis.". mSphere (2018): http://europepmc.org/abstract/med/30381350.
    10.1128/mSphere.00352-18
  22. Gaifem J; Gonçalves LG; Dinis-Oliveira RJ; Cunha C; Carvalho A; Torrado E; Rodrigues F; et al. "L-Threonine Supplementation During Colitis Onset Delays Disease Recovery.". Frontiers in physiology (2018): http://europepmc.org/abstract/med/30233416.
    10.3389/fphys.2018.01247
  23. Bruger AM; Dorhoi A; Esendagli G; Barczyk-Kahlert K; van der Bruggen P; Lipoldova M; Perecko T; et al. "How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions.". Cancer immunology, immunotherapy : CII (2018): http://europepmc.org/abstract/med/29785656.
    10.1007/s00262-018-2170-8
  24. Alejo A; Ruiz-Argüello MB; Pontejo SM; Fernández de Marco MDM; Saraiva M; Hernáez B; Alcamí A. "Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation.". Nature communications (2018): http://europepmc.org/abstract/med/29724993.
    10.1038/s41467-018-04098-8
  25. Cardoso A; Gil Castro A; Martins AC; Carriche GM; Murigneux V; Castro I; Cumano A; Vieira P; Saraiva M. "The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis.". Frontiers in immunology (2018): http://europepmc.org/abstract/med/29545807.
    10.3389/fimmu.2018.00400
  26. Bastos HN; Osório NS; Gagneux S; Comas I; Saraiva M. "The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes.". Frontiers in immunology (2017): http://europepmc.org/abstract/med/29375571.
    10.3389/fimmu.2017.01948
  27. Fonseca, K.L.; Rodrigues, P.N.S.; Olsson, I.A.S.; Saraiva, M.. "Experimental study of tuberculosis: From animal models to complex cell systems and organoids". PLoS Pathogens 13 8 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85028681914&partnerID=MN8TOARS.
    10.1371/journal.ppat.1006421
  28. Cunha, C.; Gonçalves, S.M.; Duarte-Oliveira, C.; Leite, L.; Lagrou, K.; Marques, A.; Lupiañez, C.B.; et al. "IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity". Journal of Allergy and Clinical Immunology 140 3 (2017): 867-870.e9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019152778&partnerID=MN8TOARS.
    10.1016/j.jaci.2017.02.034
  29. Gonçalves, N.P.; Moreira, J.; Martins, D.; Vieira, P.; Obici, L.; Merlini, G.; Saraiva, M.; Saraiva, M.J.. "Differential expression of Cathepsin E in transthyretin amyloidosis: From neuropathology to the immune system". Journal of Neuroinflammation 14 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020206626&partnerID=MN8TOARS.
    10.1186/s12974-017-0891-9
  30. Domingues, N.; Estronca, L.M.B.B.; Silva, J.; Encarnação, M.R.; Mateus, R.; Silva, D.; Santarino, I.B.; et al. "Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1862 2 (2017): 210-220. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999089924&partnerID=MN8TOARS.
    10.1016/j.bbalip.2016.10.009
  31. Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.. "Interferon-ß regulates the production of IL-10 by toll-like receptor-activated microglia". GLIA 65 9 (2017): 1439-1451. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021258982&partnerID=MN8TOARS.
    10.1002/glia.23172
  32. Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.. "Balancing the immune response in the brain: IL-10 and its regulation". Journal of Neuroinflammation 13 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997106994&partnerID=MN8TOARS.
    10.1186/s12974-016-0763-8
  33. Moreira-Teixeira, L.; Sousa, J.; McNab, F.W.; Torrado, E.; Cardoso, F.; Machado, H.; Castro, F.; et al. "Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-¿ signaling". Journal of Immunology 197 12 (2016): 4714-4726. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002328285&partnerID=MN8TOARS.
    10.4049/jimmunol.1600584
  34. Stucki, D.; Brites, D.; Jeljeli, L.; Coscolla, M.; Liu, Q.; Trauner, A.; Fenner, L.; et al. "Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages". Nature Genetics 48 12 (2016): 1535-1543. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992759009&partnerID=MN8TOARS.
    10.1038/ng.3704
  35. Howes, A.; Taubert, C.; Blankley, S.; Spink, N.; Wu, X.; Graham, C.M.; Zhao, J.; et al. "Differential production of Type I IFN Determines the Reciprocal Levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages". Journal of Immunology 197 7 (2016): 2838-2853. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989939029&partnerID=MN8TOARS.
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  36. Bastos, H.N.; Osório, N.S.; Castro, A.G.; Ramos, A.; Carvalho, T.; Meira, L.; Araújo, D.; et al. "A prediction rule to stratify mortality risk of patients with pulmonary tuberculosis". PLoS ONE 11 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84992386220&partnerID=MN8TOARS.
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  37. Cruz, A.; Torrado, E.; Carmona, J.; Fraga, A.G.; Costa, P.; Rodrigues, F.; Appelberg, R.; et al. "BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells". Vaccine 33 1 (2015): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919360521&partnerID=MN8TOARS.
    10.1016/j.vaccine.2014.11.013
  38. Carvalho, A.; Costa, P.; Triunfante, V.; Branca, F.; Rodrigues, F.; Santos, C.L.; Correia-Neves, M.; et al. "Analysis of a local HIV-1 epidemic in portugal highlights established transmission of Non-B and Non-G subtypes". Journal of Clinical Microbiology 53 5 (2015): 1506-1514. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928032043&partnerID=MN8TOARS.
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  39. Cruz, A.; Ludovico, P.; Torrado, E.; Gama, J.B.; Sousa, J.; Gaifem, J.; Appelberg, R.; et al. "IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages". Frontiers in Immunology 6 SEP (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946550863&partnerID=MN8TOARS.
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  40. Cardoso, F.; Castro, F.; Moreira-Teixeira, L.; Sousa, J.; Torrado, E.; Silvestre, R.; Castro, A.G.; Saraiva, M.; Pais, T.F.. "Myeloid sirtuin 2 expression does not impact long-term Mycobacterium tuberculosis control". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940426429&partnerID=MN8TOARS.
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  41. Teixeira-Coelho, M.; Guedes, J.; Ferreirinha, P.; Howes, A.; Pedrosa, J.; Rodrigues, F.; Lai, W.S.; et al. "Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages". European Journal of Immunology 44 3 (2014): 856-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896030127&partnerID=MN8TOARS.
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  42. McNab, F.W.; Ewbank, J.; Howes, A.; Moreira-Teixeira, L.; Martirosyan, A.; Ghilardi, N.; Saraiva, M.; O'Garra, A.. "Type i IFN induces IL-10 production in an IL-27-Independent manner and blocks responsiveness to IFN-¿ for production of IL-12 and bacterial killing in mycobacterium tuberculosis-infected macrophages". Journal of Immunology 193 7 (2014): 3600-3612. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907215689&partnerID=MN8TOARS.
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  43. McNab, F.W.; Ewbank, J.; Rajsbaum, R.; Stavropoulos, E.; Martirosyan, A.; Redford, P.S.; Wu, X.; et al. "TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production". Journal of Immunology 191 4 (2013): 1732-1743. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881454396&partnerID=MN8TOARS.
    10.4049/jimmunol.1300146
  44. Osório, N.S.; Rodrigues, F.; Gagneux, S.; Pedrosa, J.; Pinto-Carbó, M.; Castro, A.G.; Young, D.; Comas, I.; Saraiva, M.. "Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure". Molecular Biology and Evolution 30 6 (2013): 1326-1336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727980&partnerID=MN8TOARS.
    10.1093/molbev/mst038
  45. Carmona, J.; Cruz, A.; Moreira-Teixeira, L.; Sousa, C.; Sousa, J.; Osorio, N.S.; Saraiva, A.L.; et al. "Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response". PLoS ONE 8 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879468975&partnerID=MN8TOARS.
    10.1371/journal.pone.0067277
  46. Menino, J.F.; Saraiva, M.; Gomes-Rezende, J.; Sturme, M.; Pedrosa, J.; Castro, A.G.; Ludovico, P.; Goldman, G.H.; Rodrigues, F.. "P. brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation". PLoS ONE 8 9 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884191896&partnerID=MN8TOARS.
    10.1371/journal.pone.0074725
  47. Menino, J.F.; Saraiva, M.; Gomes-Alves, A.G.; Lobo-Silva, D.; Sturme, M.; Gomes-Rezende, J.; Saraiva, A.L.; et al. "TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival". PLoS Neglected Tropical Diseases 7 7 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880846173&partnerID=MN8TOARS.
    10.1371/journal.pntd.0002317
  48. Martins, T.G.; Trigo, G.; Fraga, A.G.; Gama, J.B.; Longatto-Filho, A.; Saraiva, M.; Silva, M.T.; Castro, A.G.; Pedrosa, J.. "Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulcerans Infection". PLoS Neglected Tropical Diseases 6 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84870754979&partnerID=MN8TOARS.
    10.1371/journal.pntd.0001925
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  52. Fraga, A.G.; Cruz, A.; Martins, T.G.; Torrado, E.; Saraiva, M.; Pereira, D.R.; Meyers, W.M.; et al. "Mycobacterium ulcerans triggers T-cell immunity followed by local and regional but not systemic immunosuppression". Infection and Immunity 79 1 (2011): 421-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650893587&partnerID=MN8TOARS.
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  53. Carvalho, A.; Osório, N.S.; Saraiva, M.; Cunha, C.; Almeida, A.J.; Teixeira-Coelho, M.; Ludovico, P.; et al. "The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation". PLoS ONE 6 11 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-81755184094&partnerID=MN8TOARS.
    10.1371/journal.pone.0028256
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Livro
  1. Gabryšová, L.; Howes, A.; Saraiva, M.; O'Garra, A.. The regulation of IL-10 expression. 2014.
    10.1007/978-3-662-43492-5-8
  2. Gabryšová, L.; Howes, A.; Saraiva, M.; O'Garra, A.. The regulation of IL-10 expression. 2014.
    10.1007/978-3-662-43492-5_8
  3. Alcami, A.; Saraiva, M.. Chemokine binding proteins encoded by pathogens. 2009.
    10.1007/978-1-4419-1601-3_13
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/03/05 Mycobacterium tuberculosis diversity: what is it teaching us 27. Symposium: “Infection and Immune Defense“ - German Society for Immunology
German Society for Immunology - Study Group Infection Immunology (Alemanha)
2023/12 TB-spectrum: laboratory markers in connection with clinical significance Training school of the Advance-TB COST Action
2023/06 Study of host pathogen interactions in TB using in clinico to in vitro to in vivo approaches- What can we learn? European Society of Mycobacteriology
(Albânia)
2023/03/19 Tuberculosis basic Biology- using Mycobacterium tuberculosis diversity to understand tuberculosis Tuberculosis symposium
Basel TPH (Basel, Suiça)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/01/01 - Atual Understanding tuberculosis infection and disease progression using Mycobacterium africanum as a model
Orientador
 PhD (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09/01 - Atual Understanding the molecular bases dictating TB severity
Orientador
 PhD in Molecular and Cell Biology (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/01/01 - 2026/12/31 Deciphering the contribution of the epithelium to tuberculosis severity: from alveolar epithelial cells to epithelioid macrophages
Orientador
 PhD in Molecular and Cell Biology (Doutoramento)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/01/01 - 2026/12/31 Improved predictive models for SARS-CoV-2 infection
Coorientador
 PhD in Molecular and Cell Biology (Doutoramento)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/09/01 - 2024/01 Exploring Mycobacterium tuberculosis immune evasion strategies to improve host immunity and tuberculosis outcome: the IL-1 axis
Orientador
 Doutoramento em Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/01 - 2023/09/25 Decoding the mechanisms linking IL-10-driven to cellular senescence and aging
Orientador
 Doutoramento em Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/09/01 - 2022/12/03 Deciphering the in vivo mechanisms underlying the IL-10-mediated differentiation of IFNg-producing T cells
Orientador
Universidade do Porto Faculdade de Ciências, Portugal
2021/09/01 - 2022/12/03 Understanding the impact of the Mycobacterium tuberculosis complex diversity in tuberculosis
Orientador
Universidade do Porto Faculdade de Ciências, Portugal
2021/09/01 - 2022/09/01 Understanding the modulation of myeloid cell responses by clinical isolates of Mycobacterium tuberculosis associated with mild or severe tuberculosis
Orientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09/01 - 2021/12/03 Interleukin 1 manipulation by Mycobacterium tuberculosis : impact to the infection establishment and progression
Orientador
Universidade do Porto Faculdade de Ciências, Portugal
2016/01/01 - 2020/03/04 Impact of Host Glycosylation in Tuberculosis
Orientador
 Doutoramento em Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/10/01 - 2020/01/28 UNDERSTANDING HOST-PATHOGEN INTERACTIONS IN TUBERCULOSIS: LESSONS FROM MYCOBACTERIUM AFRICANUM
Orientador
 Doutoramento em Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/11/01 - 2020/01/14 THE YIN AND YAN OF HOST-PATHOGEN INTERACTIONS IN TUBERCULOSIS
Orientador
 Doutoramento em Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2019 The impact of Mycobacterium tuberculosis diversity to the course of infection
Orientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/01/01 - 2018/07/19 Impact of regulatory cytokines in hematopoiesis
Orientador
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2013/01/01 - 2017/04/17 IDENTIFICATION OF HUMAN AND PATHOGEN MOLECULAR VARIANTS ASSOCIATED TO TUBERCULOSIS HETEROGENEITY
Orientador
 Doutoramento em Medicina (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2016 - 2017 Decoding the role of IL-10 in aging
Orientador
Universidade do Minho Escola de Ciências, Portugal
2016 - 2017 Funtional impact of differential IL-1 signaling in tuberculosis
Orientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2016 IL-10 overexpression drives myelopoiesis and premature aging
Orientador
Universidade do Porto Faculdade de Ciências, Portugal
2014 - 2015 The mechanisms underlying Mycobacterium tuberculosis virulence granted by the nrp gene
Orientador
Universidade do Minho Escola de Medicina, Portugal
2014 - 2015 Impact of IL-10 over-expression in dextran sodium sulfate induced acute and chronic colitis
Orientador
Universidade do Minho Escola de Medicina, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2018/07/01 - Atual Invited speaker @ the 2018 Annual Meeting of the European Society for Mycobacteriology
Congresso
 Annual Meeting of the European Society for Mycobacteriology
2018 - Atual Invited speaker @ The Francis Crick Institute, London
Seminário
2017/03/04 - Atual Invited speaker @ the 2017 EFIS on the road symposium
Simpósio
 Meeting of the European Federation of Immunological Societies
2017 - Atual Invited speaker @ Max Plank Institute for Infection, Berlin
Seminário
 Invited seminar - Max Plank Institute for Infection
2022/10/22 - 2022/10/22 Invited speaker at the Innovate4TB annual meeting
Congresso
2022/06/22 - 2022/06/22 Invited speaker at the Inflammazoom seminar series
Conferência
2022/04/20 - 2022/04/20 Invited speaker at the Annual Meeting of the Portuguese Society for Immunology 2022
Congresso
2021/06/07 - 2021/06/07 Invited speaker at IMM seminar series
Conferência
2020/10/03 - 2020/10/03 Invited speaker at TB-Science 2020
Conferência
2020/06/04 - 2020/06/04 Invited speaker at the IGC seminar series
Conferência

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2015/04/01 - Atual Immunity Inflammation and Disease (2050-4527) Wiley (John Wiley & Sons)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2023/06/14 - 2033/06/15 Member of the Life Sciences panel for the La Caixa PhD fellowships.
Avaliador
 La Caixa Research Foundation, Espanha

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020/02/01 - Atual Member of the Scientific Advisory Board for a H2020 project
Membro
2020 - Atual Member of the Scientific Advisory Board of the PhD program Molecular and Cellular Biology
Membro
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/06/05 - Atual President of the Portuguese Society for Immunology
Presidente / Vice-presidente
 Sociedade Portuguesa de Imunologia, Portugal
2024/01 - 2026/12 Member of the Scientific Council of the Jerome Lejeune foundation
Consultor
 Fondation Jérôme Lejeune, França
2022/10/01 - 2025/09/30 Management Committee and Work Group Leader - COST Action TB Advance
Membro
 Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Espanha
2020/01/01 - 2024/01/01 Scientific Advisory Board Member- EU project SMA-TB
Consultor
 Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Espanha
2015/06/01 - 2018/12/30 Member of the management committee of the COST Action MyeEUNITER
Membro

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2014 - 2015 Member of the Evaluation panel for PhD and Post-doctoral fellowships - FCT Fundação para a Ciência e a Tecnologia, Portugal
Distinções

Outra distinção

2021 Testing and defining the correlates of protection to a new inhaled COVID-19 vaccine.
British Society for Antimicrobial Chemotherapy, Reino Unido
2018 Host prognostic markers of effective Mycobacterium tuberculosis infection in latency.
British Society for Antimicrobial Research , Reino Unido
2018 Janssen Award for Innovation – Honorable distinction: The anti-inflammatory cytokine IL-10 is a new determinant of hematopoietic lineage commitment. 2018.
2015 2015 Research Grant from the European Society for Clinical Microbiology and Infectious Diseases (ESCMID)- Deciphering the candidate Mycobacterium tuberculosis molecular signatures of TLR2 vs TLR4 activation.
2013 Fundação Amélia de Mello/José de Mello Saúde Prize for clinical research
2013 Royal Academy of Sciences Exchange Research Prize
2011 ICVS-Incentive to Reseach