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Dr. Colin McVey completed his Bachelor's degree in Biochemistry in 1991 at the Queen's University in Belfast. He obtained his master’s in clinical laboratory medicine in the Dept of Haematology, from the same university in 1992, and his Doctor of Philosophy in Chemistry from the University of York in 2000. He has worked as a Research Assistant, Postdoc and Auxiliary Researcher at various academic institutions in the UK and Portugal. Since 2014, he has been a Principal Investigator (Research) at Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica. Dr. Colin McVey's research interests are in Biological Sciences with an emphasis on Biophysics, related to the fields of Virology and DNA binding proteins. In his professional activities, he has interacted with 132 collaborator(s) in co-authorship of scientific papers. He has published in high-impact journals and 4 book chapters. His scientific output has focussed on Structural Biology, in the areas of protein crystallization, and DNA viruses, particularly in the area of herpesvirus biology. His current focus is on the multifaceted latency-associated nuclear antigen (LANA) and its role in viral latency, DNA binding mechanism and chromatin modulation.
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Identificação

Identificação pessoal

Nome completo
Colin McVey

Nomes de citação

  • McVey, Colin E.

Identificadores de autor

Ciência ID
EC1C-6BBD-4E1C
ORCID iD
0000-0001-7457-2130

Moradas

  • Instituto de Tecnologia Química e Biológica . Structural Virology Lab, Macromolecular Crystallography Unit, ITQB, Av.de República, EAN, 2780-157, Oeiras, Oeiras, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biofísica
  • Ciências Naturais - Ciências Biológicas - Virologia
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês (Idioma materno)
Português Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
1996/10/01 - 2000/02/28
Concluído
 Chemistry (Doctor of Philosophy)
University of York Department of Chemistry, Reino Unido
"Structure function studies of Penicillin G acylase from E. coli" (TESE/DISSERTAÇÃO)
 DPhil
1992
Concluído
 Masters in Clinical Laboratory Medicine (Master)
Queen's University Belfast, Reino Unido
"Expression cloning of murine erythropoietin" (TESE/DISSERTAÇÃO)
 M.Med.Sc
1991
Concluído
 Biochemistry (Bachelor)
Queen's University Belfast Centre for Biomedical Sciences Education, Reino Unido
"N/A" (TESE/DISSERTAÇÃO)
 BSc (Hons)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/10/01 - Atual Investigador principal (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/02/01 - 2019/01/31 Investigador principal (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/07/01 - 2014/01/31 Investigador Auxiliar (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2004/04/01 - 2007/03/31 Pós-doutorado (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2001/09/01 - 2004/03/31 Pós-doutorado (Investigação) Imperial College Faculty of Medicine - Saint Mary's Campus, Reino Unido
1999/02/01 - 2001/08/31 Pós-doutorado (Investigação) Sir William Dunn School of Pathology, Reino Unido
1993/03/01 - 1999/09/30 Assistente de Investigação (carreira) (Investigação) University of York Department of Chemistry, Reino Unido

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/07/01 - 2009/06/30 Spine2 deputy coordinator (Oeiras, Portugal) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projetos

Bolsa

Designação Financiadores
2014/10 - 2019/10 STRUCTURAL STUDIES ON LANA INTERACTIONS AND ITS IMPACT ON TUMOUR VIRAL LATENT INFECTION
Provided by PTCRIS: 147538
IF/01023/2013/CP1173/CT0003
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2011/11 - 2015/07 Pathogenesis of Kaposi's sarcoma herpesvirus LANA
Provided by PTCRIS: 116380
3529675
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Medicina Molecular, Portugal

Harvard Medical School, Estados Unidos
Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2014/08 GRIM-19, a novel protein involved in cell apoptosis: structure-function characterization
Provided by PTCRIS: 113064
 Fundação para a Ciência e a Tecnologia, I.P.
2006/07/01 - 2010/06/30 SPINE2-COMPLEXES Integrated project LSHG CT-2006-031220
LSHG-CT-2006- 031220
Investigador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 European Commission Seventh Framework Programme for Research and Technological Development Health
Concluído
2007/01 - 2008/12 Structure function studies of murine Toll-like receptors: Activation of the innate immune response
Provided by PTCRIS: 82296
 Fundação para a Ciência e a Tecnologia, I.P.
2005/05 - 2008/06 Structural genomics and human pathogenic bacteria
Provided by PTCRIS: 63856
 Fundação para a Ciência e a Tecnologia, I.P.
2005/09 - 2008/03 Structure function studies of murine Toll-like receptors: Activation of the innate immune response
Provided by PTCRIS: 55729
 Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

BioResources 4 Sustainability, Portugal

Universidade NOVA de Lisboa, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 iNOVA4Health - Programa de Medicina Translacional (iBET, CEDOC/FCM, IPOLFG e ITQB)
UID/Multi/04462/2019
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 4 - 2011-2012
PEst-OE/EQB/LA0004/2011
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/09/01 - 2008/03/31 Estudos estruturais e funcionais de receptores Toll-like: Activação da resposta imunitária inata
POCI/SAU-IMI/55729/2004
Fundação Calouste Gulbenkian, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Tan, Min; Li, Shijun; Juillard, Franceline; Chitas, Rute; Custódio, Tânia F; Xue, Han; Szymula, Agnieszka; et al. "MLL1 is regulated by KSHV LANA and is important for virus latency". Nucleic Acids Research 49 22 (2021): 12895-12911. http://dx.doi.org/10.1093/nar/gkab1094.
    Publicado • 10.1093/nar/gkab1094
  2. Pires de Miranda, Marta; Quendera, Ana Patrícia; McVey, Colin E.; Kaye, Kenneth M.; Simas, J. Pedro. "In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4". Journal of Virology 92 21 (2018): http://dx.doi.org/10.1128/jvi.01251-18.
    Acesso aberto • 10.1128/jvi.01251-18
  3. Habison, A.C.; de Miranda, M.P.; Beauchemin, C.; Tan, M.; Cerqueira, S.A.; Correia, B.; Ponnusamy, R.; et al. "Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA". PLoS Pathogens 13 9 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030456472&partnerID=MN8TOARS.
    10.1371/journal.ppat.1006555
  4. Campos, E.J.; McVey, C.E.; Astier, Y.. "Stochastic Detection of MPSA-Gold Nanoparticles Using a a-Hemolysin Nanopore Equipped with a Noncovalent Molecular Adaptor". Analytical Chemistry 88 12 (2016): 6214-6222. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975794177&partnerID=MN8TOARS.
    10.1021/acs.analchem.5b03558
  5. Cerqueira, S.A.; Tan, M.; Li, S.; Juillard, F.; McVey, C.E.; Kaye, K.M.; Simas, J.P.. "Latency-associated nuclear antigen E3 ubiquitin ligase activity impacts gammaherpesvirus-driven germinal center B cell proliferation". Journal of Virology 90 17 (2016): 7667-7683. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983567949&partnerID=MN8TOARS.
    10.1128/JVI.00813-16
  6. Pedersen, H.L.; Johnson, K.A.; Mcvey, C.E.; Leiros, I.; Moe, E.. "Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA". Acta Crystallographica Section D: Biological Crystallography 71 (2015): 2137-2149. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944217343&partnerID=MN8TOARS.
    10.1107/S1399004715014157
  7. Ponnusamy, R.; Petoukhov, M.V.; Correia, B.; Custodio, T.F.; Juillard, F.; Tan, M.; Pires De Miranda, M.; et al. "KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA". Nucleic Acids Research 43 20 (2015): 10039-10054. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949978455&partnerID=MN8TOARS.
    10.1093/nar/gkv987
  8. Li, S.; Tan, M.; Juillard, F.; Ponnusamy, R.; Correia, B.; Simas, J.P.; Carrondo, M.A.; McVey, C.E.; Kaye, K.M.. "The Kaposi sarcoma herpesvirus latency-associated nuclear antigen DNA binding domain dorsal positive electrostatic patch facilitates DNA replication and episome persistence". Journal of Biological Chemistry 290 47 (2015): 28084-28096. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947703640&partnerID=MN8TOARS.
    10.1074/jbc.M115.674622
  9. McVey, C.E.; Ferreira, M.J.; Correia, B.; Lahiri, S.; De Sanctis, D.; Carrondo, M.A.; Lindley, P.F.; et al. "The importance of the Abn2 calcium cluster in the endo-1,5-arabinanase activity from Bacillus subtilis Topical Issue in honor of Ivano Bertini. Guest editors: Lucia Banci, Claudio Luchinat". Journal of Biological Inorganic Chemistry 19 4-5 (2014): 505-513. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901949682&partnerID=MN8TOARS.
    10.1007/s00775-014-1105-x
  10. Campos, E.; McVey, C.E.; Carney, R.P.; Stellacci, F.; Astier, Y.; Yates, J.. "Sensing single mixed-monolayer protected gold nanoparticles by the a-hemolysin nanopore". Analytical Chemistry 85 21 (2013): 10149-10158. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887738853&partnerID=MN8TOARS.
    10.1021/ac4014836
  11. Pires De Miranda, M.; Lopes, F.B.; McVey, C.E.; Bustelo, X.R.; Simas, J.P.. "Role of Src homology domain binding in signaling complexes assembled by the murid gamma-herpesvirus M2 protein". Journal of Biological Chemistry 288 6 (2013): 3858-3870. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873692786&partnerID=MN8TOARS.
    10.1074/jbc.M112.439810
  12. Correia, B.; Cerqueira, S.A.; Beauchemin, C.; Pires de Miranda, M.; Li, S.; Ponnusamy, R.; Rodrigues, L.; et al. "Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency". PLoS Pathogens 9 10 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84887309755&partnerID=MN8TOARS.
    10.1371/journal.ppat.1003673
  13. Campos, E.; Asandei, A.; McVey, C.E.; Dias, J.C.; Oliveira, A.S.F.; Soares, C.M.; Luchian, T.; Astier, Y.. "The role of lys147 in the interaction between MPSA-gold nanoparticles and the a-hemolysin nanopore". Langmuir 28 44 (2012): 15643-15650. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868607116&partnerID=MN8TOARS.
    10.1021/la302613g
  14. Gorynia, S.; Bandeiras, T.M.; Pinho, F.G.; McVey, C.E.; Vonrhein, C.; Round, A.; Svergun, D.I.; et al. "Structural and functional insights into a dodecameric molecular machine - The RuvBL1/RuvBL2 complex". Journal of Structural Biology 176 3 (2011): 279-291. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455176998&partnerID=MN8TOARS.
    10.1016/j.jsb.2011.09.001
  15. de Sanctis, D.; McVey, C.E.; Enguita, F.J.; Carrondo, M.A.. "Crystal Structure of the Full-Length Sorbitol Operon Regulator SorC from Klebsiella pneumoniae: Structural Evidence for a Novel Transcriptional Regulation Mechanism". Journal of Molecular Biology 387 3 (2009): 759-770. http://www.scopus.com/inward/record.url?eid=2-s2.0-62049085612&partnerID=MN8TOARS.
    10.1016/j.jmb.2009.02.017
  16. De Sanctis, D.; Rêgo, A.T.; Marçal, D.; McVey, C.E.; Carrondo, M.A.; Enguita, F.J.. "Overexpression, purification and crystallization of the tetrameric form of SorC sorbitol operon regulator". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64 1 (2007): 22-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549029828&partnerID=MN8TOARS.
    10.1107/S1744309107060897
  17. Cooray, S.; Bahar, M.W.; Abrescia, N.G.A.; McVey, C.E.; Bartlett, N.W.; Chen, R.A.-J.; Stuart, D.I.; Grimes, J.M.; Smith, G.L.. "Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein". Journal of General Virology 88 6 (2007): 1656-1666. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249787896&partnerID=MN8TOARS.
    10.1099/vir.0.82772-0
  18. Frazão, C. *; McVey, Colin E. *; Amblar, M. *; Barbas, A.; Vonrhein, C.; Arraiano, C.M.; Carrondo, M.A.. Autor correspondente: Arraiano, C.M.. "Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex". Nature 443 7107 (2006): 110-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748414894&partnerID=MN8TOARS https://www.nature.com/articles/nature05080#author-information.
    Publicado • 10.1038/nature05080
  19. McVey, C.E.; Amblar, M.; Barbas, A.; Cairrão, F.; Coelho, R.; Romáo, C.; Arraiano, C.M.; Carrondo, M.A.; Frazão, C.. "Expression, purification, crystallization and preliminary diffraction data characterization of Escherichia coli ribonuclease II (RNase II)". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62 7 (2006): 684-687. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745684855&partnerID=MN8TOARS.
    10.1107/S1744309106021506
  20. Bartlett, N.W.; Dumoutier, L.; Renauld, J.-C.; Kotenko, S.V.; McVey, C.E.; Lee, H.-J.; Smith, G.L.. "A new member of the interleukin 10-related cytokine family encoded by a poxvirus". Journal of General Virology 85 6 (2004): 1401-1412. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942633388&partnerID=MN8TOARS.
    10.1099/vir.0.79980-0
  21. Morillas, M.; McVey, C.E.; Brannigan, J.A.; Ladurner, A.G.; Forney, L.J.; Virden, R.. "Mutations of penicillin acylase residue B71 extend substrate specificity by decreasing steric constraints for substrate binding". Biochemical Journal 371 1 (2003): 143-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242286152&partnerID=MN8TOARS.
    10.1042/BJ20021383
  22. McVey, C.E.; Walsh, M.A.; Dodson, G.G.; Wilson, K.S.; Brannigan, J.A.. "Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism". Journal of Molecular Biology 313 1 (2001): 139-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035850792&partnerID=MN8TOARS.
    10.1006/jmbi.2001.5043
  23. Brannigan, J.A.; Dodson, G.G.; Done, S.H.; Hewitt, L.; McVey, C.E.; Wilson, K.S.. "Structural studies of penicillin acylase". Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology 88 1-3 (2000): 313-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033790948&partnerID=MN8TOARS.
  24. Suresh, C.G.; Pundle, A.V.; SivaRaman, H.; Rao, K.N.; Brannigan, J.A.; McVey, C.E.; Verma, C.S.; et al. "Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members". Nature Structural Biology 6 5 (1999): 414-416. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032915960&partnerID=MN8TOARS.
    10.1038/8213
  25. McVey, C.E.; Tolley, S.P.; Done, S.H.; Brannigan, J.A.; Wilson, K.S.. "A new crystal form of penicillin acylase from Escherichia coli". Acta Crystallographica Section D: Biological Crystallography 53 6 (1997): 777-779. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030782436&partnerID=MN8TOARS.
    10.1107/S0907444997006707
Capítulo de livro
  1. Gorynia, Sabine; Bandeiras, Tiago M.; Matias, Pedro M.; Pinho, Filipa G.; McVey, Colin E.; Donner, Peter; Carrondo, Maria Arménia. "RuvBL1 and RuvBL2 and Their Complex Proteins Implicated in Many Cellular Pathways". In NATO Science for Peace and Security Series A: Chemistry and Biology, editado por Carrondo, M.A.; Spadon, P., 55-63. Springer Netherlands, 2011.
    Publicado • 10.1007/978-94-007-2530-0_5
  2. Frazão, Carlos; McVey, Colin E.; Carrondo, MA. "Determinação da Estrutura da Ribonuclease II: uma enzima importante no controlo da expressão génica.". In Annualia, editado por Colaço, Jorge. Lisboa, Portugal: Editorial Verbo, 2007.
    Publicado
  3. Brannigan, J.A.; Ladurner, A.G.; McVey, Colin E.; Forney, L.J.. "Altered specificity mutants of penicillin acylase.". In In Perspectives on Protein Engineering, editado por Geisow M.; Epton, R., 124-126. Reino Unido: Mayflower Worldwide Ltd, 1995.
    Publicado
Livro
  1. Gorynia, S.; Bandeiras, T.M.; Matias, P.M.; Pinho, F.G.; McVey, C.E.; Donner, P.; Carrondo, M.A.. RuvBL1 and RuvBL2 and their complex proteins implicated in many cellular pathways. 2012.
    10.1007/978-94-007-2530-0_5
Poster em conferência
  1. Joana Batuca; McVey, Colin; Maria Arménia Carrondo; José Delgado Alves. "Anti-apolipoprotein A-I (ApoA-I) antibodies have different target epitopes in different clinical conditions". 2017.
    : https://doi.org/10.1016/j.atherosclerosis.2017.06.705
  2. Chitas, Rute; Ponnusamy, Rajesh; Custódio, Tânia F.; McVey, Colin E.. "Structural and biochemical analysis of LANA interactions with USP7". Trabalho apresentado em 20th International Workshop on Kaposi's Sarcoma Herpes Virus (KSHV) and Related Agents, 2017.
  3. Rute Chitas; Rajesh Ponnusamy; Tânia Custódio; McVey, Colin. "Structural and Biochemical Analysis of LANA interactions with USP7: Incorporation of a glutamine residue in substrate competition by KSHV LANA". Trabalho apresentado em 20th International Workshop on Kaposi ´s Sarcoma Herpes Virus (KSHV) and Related Agents, 2017.
  4. McVey, Colin E.; Marta Pires de Miranda; Pedro Simas. "Structural Virology of the Murid gamma-Herpesvirus 4 – Crystal structure of the latency-associated nuclear antigen (LANA) protein.". Trabalho apresentado em Eurovirology 2013: 5th European Congress of Virology, 2013.
  5. McVey, Colin E.; Marta Pires de Miranda. "“Improving crystal quality by combined Bioinformatics, Biophysical Characterization and Seeding Techniques.”". Trabalho apresentado em FEBS Practical Course. “Advanced Methods in Protein Crystallization V”, 19 to 22 June 2012 Academic and University Center at Nové Hrady, Czech Republic., 2012.
  6. McVey, Colin E.; Marta Pires de Miranda; Pedro Simas. "“Protein-protein interactions mediated by the gammaherpesvirus M2 protein”". Trabalho apresentado em EMBO meeting 2009 (Amesterdam, 29.Aug - 2 September 2009), 2009.
  7. McVey, Colin E.; Francisco Javier Enguita. "Crystal Structure of the Full-Length Sorbitol Operon Regulator SorC from Klebsiella pneumoniae: Structural Evidence for a Novel Transcriptional Regulation Mechanism". Trabalho apresentado em 25th European Crystallographic Meeting 16th to 21st. August 2009 in Istanbul, Turkey., 2009.
  8. McVey, Colin E.. "Nucleotide-binding Oligomerization Domain 2 (NOD2) interacts with its ligands through key domains two different approaches". Trabalho apresentado em SPINE2-COMPLEXES Annual meeting from July 15th to July 16th 2009. Lisbon, Portugal., 2009.
  9. McVey, Colin E.. "Biophysical characterization of the murine CARD-CARD domain of NOD2.". Trabalho apresentado em SPINE2-COMPLEXES Annual meeting from July 15th to July 16th 2009. Lisbon, Portugal., 2009.
  10. McVey, Colin E.. "A Scanning library approach to successful NLR expression.". Trabalho apresentado em SPINE2 First Annual Congress (Prague 8-10 June 2007), 2007.
  11. McVey, Colin E.; Barbas, Ana; Amblar, M.; Frazão, Carlos; Arraiano, C.M.; Carrondo, MA. "Crystallisation of and crystallographic analysis of RNase II from E. coli.". Trabalho apresentado em Protein Society Meeting, Barcelona, 2005.
  12. McVey, Colin E.. "Altering the substrate specificity of penicillin acylase". Trabalho apresentado em The Protein Society Second European Symposium, 1997.
Resumo em conferência
  1. McVey, Colin E.. "Viral regulation of a histone methyltransferase". Trabalho apresentado em American Society for Virology Annual Meeting, Madison, 2022.
    Aceite para publicação
  2. Campos, Elisa J.; Asandei, Alina; McVey, Colin E.; dias, joão carlos; oliveira, asf; Soares, Claudio M.; Luchian, Tudor; Astier, Yann. "Sensing modified-gold nanoparticles with the a-hemolysin pore". Trabalho apresentado em 9th International Conference on Nanosciences & Nanotechnologies (NN12), Thessaloniki, 2012.
    Publicado
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/06/09 KSHV LANA - A Chromatin Modulator SCAN Seminars
ITQB NOVA (Oeiras, Portugal)
2017/07/28 Structural and biochemical analysis of LANA interactions with USP7: Incorporation of a glutamine residue in substrate competition by KSHV LANA 20th International Workshop on Kaposi's Sarcoma Herpes Virus (KSHV) and Related Agents
Conventus Congressmanagement & Marketing GmbH (Berlin, Alemanha)
2016/03/16 The Pivotal Role of LANA in Kaposi Sarcoma Herpesvirus (KSHV) SCAN Seminars
ITQB NOVA (Oeiras, Portugal)
2014/07/17 Structural and biophysical characterisation of murine NOD2 regulation PCISBIO
ITQB NOVA (Oeiras, Portugal)
2014/02/19 Structural characterization of LANA: Impact on Herpesvirus Latency SCAN Seminars
ITQB NOVA (Oeiras, Portugal)
2012/12/09 Structural Characterization of LANA: Impact on Herpesvirus Latency Harvard-Portugal Annual Retreat
Harvard Medical School – Portugal Program in Translational Research (Lisbon, Portugal)
2010/10/09 Management and Dissemination of Structural Data Fundamentals of Modern Methods of Biocrystallography FEBS Practical and Lecture Course Biocrys 2010 - Fundamentals of Modern Methods of Biocrystallography 9th - 16th October 2010, Oeiras, Portugal
ITQB NOVA (Oeiras, Portugal)
2009/11/19 Cloning and expression in Pichia pastoris - An overview. Advanced Strategies for the Expression of Proteins and Protein Complexes in Yeast
Spine 2-Complexes Teach SG workshop (Barcelona, Espanha)
2008/10/11 Preparing Proteins for Crystallization BioCrys 2008 - Fundamentals of Modern Methods of Biocrystallography
FEBS (Oeiras, Portugal)
2008/10/03 The Crystallographic Web of Knowledge Fundamentals of Modern Methods of Biocrystallography FEBS Practical and Lecture Course Biocrys 2008 - Fundamentals of Modern Methods of Biocrystallography
FEBS (Oeiras, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/02/24 - 2024/06/01 Understanding Kaposi's Sarcoma Herpesvirus LANA interactions with chromatin modifiers.
Orientador de Ana Patrícia Costa Dias
 Biomedical Research (Mestrado)
Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2024/01/15 - 2024/03/01 (BSc Project) - Herpesvirus LANA interaction with the chromatin adapter Elongin BC.
Orientador de Sara Agostinho
 Biologia Celular e Molecular (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/07/20 - 2023/09/06 Summer Internship - Herpesvirus LANA interaction with USP7 and Elongin BC 1) Basic introduction to laboratory techniques to study protein interactions. 2) Practical instruction on how to write a lab report.
Orientador
 Bioquimica (Outra)
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2023/07/10 - 2023/09/06 (Summer Internship) - Herpesvirus LANA interaction with USP7 and Elongin BC 1) Basic introduction to laboratory techniques to study protein interactions. 2) Practical instruction on how to write a lab report.
Orientador
 Biologia Celular e Molecular (Iniciação científica)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2023/06/15 - 2023/08/30 (Summer Internship) - Herpesvirus LANA interaction with USP7 and Elongin BC. 1) Basic introduction to laboratory techniques to study protein interactions and tutorial on how to write a lab report.
Orientador de Sara Agostinho
 Biologia Celular e Molecular (Outra)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2017/09/01 - 2018/11/13 The role of Ubiquitin Specific Protease 7 on Latency associated Nuclear Antigen DNA binding
Orientador
 MSc in Biochemistry for Health (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/01/18 - 2017/05/14 Role of LANA in the establishment and maintenance of the KSHV epigenome
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/01/14 - 2016/06/28 LANA interaction with USP7
Orientador
 BSc Biochemistry research project (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/09/01 - 2015/08/31 Staying under the radar - the multifunctional LANA Protein http://hdl.handle.net/10362/16215
Orientador de Tânia filipa fernandes santos alves Custódio
 Bioquímica (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/04/01 - 2015/03/31 Structural Virology of the murid Gamma-Herpesvirus 4 (MuHV-4) - Elucidating the roles of viral latency proteins M2 and ORF73
Orientador
 Doctoral Program in Structural Biology (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/03/01 - 2013 Structural studies on mammalian innate immunity receptors FCT - DFRH - SFRH/BD/65898/2009
Coorientador
 Biological Chemistry (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2009/07/15 - 2009/07/16 Part of the organising committee for SPINE2-COMPLEXES Annual meeting from 15th- 16th July, 2009, Lisbon, Portugal. Management and creation of the Meeting and registration website . (2009/07/15 - 2009/07/16)
Conferência (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2020/02/10 - 2020/02/10 We recently had a visit from 12th-grade students of Escola Secundária da Moura as part of the "Cientificamente Provável" program, which is a joint initiative by the Ministries of Education and Science, Technology, and Higher Education. This program is designed to promote knowledge and enrich the educational experience of young people by establishing closer links between higher education, research institutions, and basic and secondary schools. It is implemented through the School Libraries Network and our science communication office.
Mesa-redonda
 Visit Moura High School - What is Research - Ask a Structural Virologist
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/12/11 PhD Jury - Effects of Wolbachia on transposable element dynamics and on fitness traits in Drosophila melanogaster
Presidente do júri
 Ana Teresa Mendes Eugénio (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2023/03/21 PhD Jury - The Role of the Periaqueductal Gray in Female Sexual Behaviour.
Presidente do júri
 Baylor Craig Brangers (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2022/04/27 Atypical culture conditions and process intensification to enhance vaccine production using insect cells
Presidente do júri
 Ricardo Jorge Carvalho Correia (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/09/20 President of PhD Jury Dissertation presented to obtain the Ph.D degree in Molecular Biosciences
Presidente do júri
 Ana Lina Pereira Rodrigues (Doutoramento)
Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/07/19 At the crossroad between innate immunity and RNA editing: Structural and biochemical studies of the Za domain family and the RNA editing enzyme ADAR1
Arguente principal
 Krzysztof Kus (Doutoramento)
Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/11/21 Phage Display as a Tool for Generation of Biotherapeutic Agents for Breast Cancer
Arguente principal
 Andreia Teixeira Ferreira (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/11/15 Human ceruloplasmin and neurotransmitters: complex stabilization and crystallization
Arguente principal
 Daniela Mesquita Moutinho (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008/11/21 Structural studies on family III alcohol dehydrogenases from pathogenic bacteria.
Vogal
 David Marçal (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022/03/10 - Atual Master of Computational Biology and Bioinformatics - The program of Biomolecular Simulation Biologia Computacional e Bioinformática (Mestrado integrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/09/01 - Atual MolBios PhD Program PhD (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/09/01 - 2021/08/31 Viruses MBpS - Functional organization of the cell Master in Biochemistry for Health (Curso de mestrado (conclusão do curso de especialização)) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2022/05/26 The subtle connection between a tumor virus and leukemia - ITQB NOVA researcher's study unravels how herpes oncoviruses are linked with a leukemia related-protein. Kaposi's sarcoma-associated herpesvirus (KSHV) is one of seven currently known human cancer viruses, or oncoviruses, and a leading cause of malignancy in AIDS. KSHV establishes persistent, lifelong infection of its human host and persists latently in tumour cells. In a new study, researchers revealed how virus latency is linked to the Mixed-lineage leukaemia 1 protein. https://www.itqb.unl.pt/news/kshv-imunocompromised
2013/11/18 Interview and newspaper article revealing the structure determination of the DNA binding domain of the LANA protein. Article also highlights the link between KSHV infection and HIV AIDS for public outreach purposes. It highlights how Kaposi¿s sarcoma went from a rare skin cancer, appearing in older men, and affecting certain parts of the globe, to a disease more spread when AIDS emerged. It also highlighted the importance of the viral LANA protein and how the structure was solved by the X-ray crystallography technique. Publico newspaper
2009/11/18 The Prémio Câmara Pestana 2008 was attributed to the research work "Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex" published in Nature (2006) by ITQB researchers, Carlos Frazão, Colin E. McVey, Mónica Amblar, Ana Barbas, Cecília M. Arraiano and Maria A. Carrondo. This is the second year in a row that this scientific award is attributed to research work produced at ITQB. https://www.rostos.pt/inicio2.asp?cronica=71738&mostra=2&seccao=as-

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/10/01 - 2023/10/31 PhD committee (Diogo Athayde) - My main role is to guide the decision-making process on the progress of the PhD and execution of the thesis plan. We convened in the first year to approve the initial plan for the thesis and once again to give final approval. Once a year, we meet to evaluate the student's progress and determine if they are making sufficient progress towards their goal.
Membro
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2013/09/04 - 2016/08/31 PhD committee (Sofia Cerqueira) - My main role is to guide the decision-making process on the progress of the PhD and execution of the thesis plan. We convened in the first year to approve the initial plan for the thesis and once again to give final approval. Once a year, we met to evaluate the student's progress and determine if they are making sufficient advances towards their goal.
Membro
 Instituto de Medicina Molecular, Portugal

Tutoria

Tópico Nome do aluno
2018/08/01 - 2018/10/31 Understanding the Interactions of the KSHV LANA protein Sara Castelli - Erasmus Traineeship Program
2012/04/01 - 2015/11/30 Training and Mentoring of a Post-Doctoral Fellow Rajesh Ponnusamy
2014/02/01 - 2015/09/30 Training and mentoring of Research assistant. Ana Sofia Ferreira-Ramos
2011/12/01 - 2014/01/31 Training and mentoring of Research assistant. Sara Loureiro Brandão
2005/07/01 - 2008/07/31 Training and mentoring of Post-doctoral Research assistant. Daniele de Sanctis
2006/09/01 - 2007/09/30 Training and mentoring of a Research assistant. Miguel Lopes
Distinções

Outra distinção

2008 Prémio Câmara Pestana 2008
Instituto Camara Pestana, Portugal

Glaxo Wellcome Farmaceutica Lda, Portugal
2007 Medalha Municipal de Mérito - Grau Ouro
Camara Municipal Oeiras, Portugal
1997 Awarded the Shell Postgraduate Chemistry Research Poster Prize.