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Bruno Fernando Bras da Silva. Concluiu o Doutoramento em Doutoramento em Química em 2009/07/31 pela Universidade do Porto e Licenciatura em Química, Ramo Científico em 2004/07/28 pela Faculdade de Ciências da Universidade do Porto. Publicou 41 artigos em revistas especializadas. Recebeu 5 prémios e/ou homenagens. Atua nas áreas da Química de Colóides, Química Física e Ciências Médicas e da Saúde com ênfase em Biotecnologia Médica, nomeadamente no desenvolvimento de métodos não-virais de veículação de genes. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Lipoplexos; Poliplexos; Lipo-poliplexos; microfluidica; Caracterização; Dispersão de pequeno-ângulo de raios-X e neutrões (SAXS e SANS).
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Identificação

Identificação pessoal

Nome completo
Bruno Fernando Bras da Silva

Nomes de citação

  • Silva, Bruno
  • Silva, Bruno F. B.

Identificadores de autor

Ciência ID
F217-9E30-387B
ORCID iD
0000-0002-8997-6311

Endereços de correio eletrónico

  • bruno.silva@empa.ch (Profissional)

Moradas

  • Empa, Lerchenfeldstrasse 5, 9014, St. Gallen, St. Gallen, Suiça (Profissional)

Domínios de atuação

  • Ciências Exatas - Química - Química de Colóides
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Exatas - Química - Química Física

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2009/07/31
Concluído
 Doutoramento em Química (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"Phase Behavior of Asymmetric Catanionic Surfactants: Equilibrium, phase transitions and microstructure" (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade
2004/07/28
Concluído
 Licenciatura em Química, Ramo Científico (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Estudo do Comportamento Termotrópico de Tensioactivos Cataniónicos e Tensioactivos Gemini" (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/01/01 - Atual Investigador principal (carreira) (Investigação) Empa - Swiss Federal Laboratories for Materials Science and Technology, Suiça
2015/09/01 - 2022/02/28 Investigador principal (carreira) (Investigação) International Iberian Nanotechnology Laboratory, Portugal
International Iberian Nanotechnology Laboratory, Portugal
2014/03/15 - 2015/08/31 Investigador visitante (Investigação) University of California Santa Barbara, Estados Unidos
University of California Santa Barbara, Estados Unidos
2013/03/01 - 2014/01/31 Pós-doutorado (Investigação) Lunds Universitet Kemicentrum, Suécia
Lunds Universitet Kemicentrum, Suécia
2011/02/01 - 2013/01/31 Pós-doutorado (Investigação) University of California Santa Barbara, Estados Unidos
University of California Santa Barbara, Estados Unidos
2009/10/01 - 2010/06/30 Pós-doutorado (Investigação) Lunds Universitet Kemicentrum, Suécia
Lunds Universitet Kemicentrum, Suécia
Projetos

Projeto

Designação Financiadores
2018/07/16 - 2021/07/15 Microfluidic Layer-by-layer Assembly of Cationic Liposome - Nucleic Acid Nanoparticles for Gene Delivery
POCI-01-0145-FEDER-032520
Investigador responsável
International Iberian Nanotechnology Laboratory, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Jamie Duburg; Jonathan Avaro; Leonard Krupnik; Silva, Bruno F. B.; Antonia Neels; Thomas J. Schmidt; Lorenz Gubler. "Design Principles for High-Performance Meta-Polybenzimidazole Membranes for Vanadium Redox Flow Batteries". ENERGY & ENVIRONMENTAL MATERIALS (2024): http://dx.doi.org/10.1002/eem2.12793.
    10.1002/eem2.12793
  2. Leonard Krupnik; Jonathan Avaro; Marianne Liebi; Neda Iranpour Anaraki; Joachim Kohlbrecher; Alla Sologubenko; Stephan Handschin; et al. "Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation". Journal of Controlled Release (2024): http://dx.doi.org/10.1016/j.jconrel.2024.02.044.
    10.1016/j.jconrel.2024.02.044
  3. Wuchao Wang; Jonathan Avaro; Tobias Hammer; Lucyna Hämmerle; Bruno F. B. Silva; Luciano Boesel; Rene Rossi; Kongchang Wei. "Hydrogel-assisted microfluidic wet spinning of poly(lactic acid) fibers from a green and pro-crystallization spinning dope". Chemical Engineering Journal (2024): http://dx.doi.org/10.1016/j.cej.2023.148417.
    10.1016/j.cej.2023.148417
  4. Juan L Paris; Ricardo Gaspar; Filipe Coelho; Pieter De Beule; Silva, Bruno F. B.. "Stability Criterion for the Assembly of Core–Shell Lipid–Polymer–Nucleic Acid Nanoparticles". ACS Nano (2023): http://dx.doi.org/10.1021/acsnano.3c07204.
    10.1021/acsnano.3c07204
  5. Cristiana Oliveira; Celso J. O. Ferreira; Miguel Sousa; Juan L Paris; Ricardo Gaspar; Bruno F. B. Silva; José Teixeira; Pedro Miguel Ferreira Santos; Claudia Botelho. "A Versatile Nanocarrier—Cubosomes, Characterization, and Applications". Nanomaterials (2022): http://dx.doi.org/10.3390/nano12132224.
    10.3390/nano12132224
  6. Daniela Araújo; Ricardo Gaspar; Dalila Mil-Homens; Mariana Henriques; Bruno Silva; S Silva. "Cationic lipid-based formulations for encapsulation and delivery of anti-EFG1 2'OMethylRNA oligomer". Medical Mycology 60 5 (2022): http://dx.doi.org/10.1093/mmy/myac030.
    10.1093/mmy/myac030
  7. Diana A. Sousa; Ricardo Gaspar; Celso Joel Oliveira Ferreira; Baltazar F; LIGIA RODRIGUES; Bruno Silva. "In Vitro CRISPR/Cas9 Transfection and Gene-Editing Mediated by Multivalent Cationic Liposome–DNA Complexes". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/5/1087.
    10.3390/pharmaceutics14051087
  8. Ana Vieira; Oscar F. Silvestre; Bruno Silva; Celso Joel Oliveira Ferreira; Ivo Lopes; Andreia C Gomes; Begoña Espiña; Marisa P. Sárria. "pH-sensitive nanoliposomes for passive and CXCR-4-mediated marine yessotoxin delivery for cancer therapy". Nanomedicine 17 10 (2022): 717-739. http://dx.doi.org/10.2217/nnm-2022-0010.
    10.2217/nnm-2022-0010
  9. Filipe Coelho; Laura M. Salonen; Bruno Silva. "Hemiacetal-linked pH-sensitive PEG-lipids for non-viral gene delivery". New Journal of Chemistry 46 32 (2022): 15414-15422. http://dx.doi.org/10.1039/d2nj02217f.
    10.1039/d2nj02217f
  10. "Influence of the media ionic strength on the formation and in vitro biological performance of polycation-DNA complexes". Journal of Molecular Liquids 344 (2021): 117930-117930. http://dx.doi.org/10.1016/j.molliq.2021.117930.
    10.1016/j.molliq.2021.117930
  11. Maria Daniela Silva; Juan L. Paris; Francisco Miguel Gama; Bruno Silva; Sanna Sillankorva. "Sustained Release of a Streptococcus pneumoniae Endolysin from Liposomes for Potential Otitis Media Treatment". ACS Infectious Diseases 7 8 (2021): 2127-2137. http://dx.doi.org/10.1021/acsinfecdis.1c00108.
    10.1021/acsinfecdis.1c00108
  12. Gómez-Varela, A.I.; Gaspar, R.; Miranda, A.; Assis, J.L.; Valverde, R.H.F.; Einicker-Lamas, M.; Silva, B.F.B.; De Beule, P.A.A.. "Fluorescence cross-correlation spectroscopy as a valuable tool to characterize cationic liposome-DNA nanoparticle assembly". Journal of Biophotonics 14 1 (2021): e202000200. http://www.scopus.com/inward/record.url?eid=2-s2.0-85091730406&partnerID=MN8TOARS.
    Publicado • 10.1002/jbio.202000200
  13. Azevedo, M.A.; Cerqueira, M.A.; Fuciños, P.; Silva, B.F.B.; Teixeira, J.A.; Pastrana, L.. "Rhamnolipids-based nanostructured lipid carriers: Effect of lipid phase on physicochemical properties and stability". Food Chemistry 344 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85097087539&partnerID=MN8TOARS.
    10.1016/j.foodchem.2020.128670
  14. Ricardo Gaspar; Filipe Coelho; Bruno F. B. Silva. "Lipid-Nucleic Acid Complexes: Physicochemical Aspects and Prospects for Cancer Treatment". Molecules 25 21 (2020): 5006. https://www.mdpi.com/1420-3049/25/21/5006.
    Acesso aberto • Publicado • 10.3390/molecules25215006
  15. Paris, Juan L.; Coelho, Filipe; Teixeira, Alexandra; Diéguez, Lorena; Silva, Bruno F. B.; Abalde-Cela, Sara. "In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture". Molecules 25 14 (2020): 3277. http://dx.doi.org/10.3390/molecules25143277.
    Acesso aberto • Publicado • 10.3390/molecules25143277
  16. Ramalheiro, A.; Paris, J.L.; Silva, B.F.B.; Pires, L.R.. "Rapidly dissolving microneedles for the delivery of cubosome-like liquid crystalline nanoparticles with sustained release of rapamycin". International Journal of Pharmaceutics 591 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092736220&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2020.119942
  17. Silva, Bruno. "Cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P)H multi-photon fluorescence lifetime imaging". Nano Research (2018): https://doi.org/10.1007/s12274-018-2231-5.
    10.1007/s12274-018-2231-5
  18. Silva, Bruno. "Enhanced magnetic microcytometer with 3D flow focusing for cell enumeration". Lab on a chip (2018): https://pubs.rsc.org/en/content/articlehtml/2018/lc/c8lc00486b.
    10.1039/c8lc00486b
  19. Silva, Bruno. "Unravelling a Mechanism of Action for a Cecropin A-Melittin Hybrid Antimicrobial Peptide: The Induced Formation of Multilamellar Lipid Stacks". Langmuir (2018): https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03639.
    10.1021/acs.langmuir.7b03639
  20. Silva, Bruno; Silva, B.F.B.. "SAXS on a chip: from dynamics of phase transitions to alignment phenomena at interfaces studied with microfluidic devices". Physical Chemistry Chemical Physics 19 35 (2017): 23690-23703. http://pubs.rsc.org/-/content/articlehtml/2017/cp/c7cp02736b.
    10.1039/C7CP02736B
  21. Silva, Bruno. "Recent advances in multiple emulsions and their application as templates". Current Opinion in Colloid & Interface Science (2016): http://www.sciencedirect.com/science/article/pii/S135902941630098X.
    10.1016/j.cocis.2016.07.006
  22. Majzoub, Ramsey N.; Chan, Chia-Ling; Ewert, Kai K.; Silva, Bruno F. B.; Liang, Keng S.; Safinya, Cyrus R.. "Fluorescence microscopy colocalization of lipid-nucleic acid nanoparticles with wildtype and mutant Rab5-GFP: A platform for investigating early endosomal events". Biochimica Et Biophysica Acta-Biomembranes 1848 6 (2015): 1308-1318. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353747500005&KeyUID=WOS:000353747500005.
    10.1016/j.bbamem.2015.03.001
  23. Silva, Bruno F. B.; Zepeda-Rosales, Miguel; Venkateswaran, Neeraja; Fletcher, Bretton J.; Carter, Lester G.; Matsui, Tsutomu; Weiss, Thomas M.; et al. "Nematic Director Reorientation at Solid and Liquid Interfaces under Flow: SAXS Studies in a Microfluidic Device". Langmuir 31 14 (2015): 4361-4371. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353177200037&KeyUID=WOS:000353177200037.
    10.1021/la5034614
  24. Silva, Bruno F. B.; Majzoub, Ramsey N.; Chan, Chia-Ling; Li, Youli; Olsson, Ulf; Safinya, Cyrus R.. "PEGylated cationic liposome-DNA complexation in brine is pathway-dependent". Biochimica Et Biophysica Acta-Biomembranes 1838 1 (2014): 398-412. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000330814000033&KeyUID=WOS:000330814000033.
    10.1016/j.bbamem.2013.09.008
  25. Majzoub, Ramsey N.; Chan, Chia-Ling; Ewert, Kai K.; Silva, Bruno F. B.; Liang, Keng S.; Jacovetty, Erica L.; Carragher, Bridget; Potter, Clinton S.; Safinya, Cyrus R.. "Uptake and transfection efficiency of PEGylated cationic liposome-DNA complexes with and without RGD-tagging". Biomaterials 35 18 (2014): 4996-5005. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335095900013&KeyUID=WOS:000335095900013.
    10.1016/j.biomaterials.2014.03.007
  26. Gentile, Luigi; Silva, Bruno F. B.; Lages, Sebastian; Mortensen, Kell; Kohlbrecher, Joachim; Olsson, Ulf. "Rheochaos and flow instability phenomena in a nonionic lamellar phase". Soft Matter 9 4 (2013): 1133-1140. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000312553900015&KeyUID=WOS:000312553900015.
    10.1039/c2sm27101j
  27. Matos, Marta R. A.; Silva, Bruno F. B.; Marques, Eduardo F.. "Chain length mismatch and packing effects on the thermotropic phase behavior of salt-free catanionic surfactants". Journal of Colloid and Interface Science 405 (2013): 134-144. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000321598400019&KeyUID=WOS:000321598400019.
    10.1016/j.jcis.2013.05.029
  28. Shirazi, Rahau S.; Ewert, Kai K.; Silva, Bruno F. B.; Leal, Cecilia; Li, Youli; Safinya, Cyrus R.. "Structural Evolution of Environmentally Responsive Cationic Liposome-DNA Complexes with a Reducible Lipid Linker". Langmuir 28 28 (2012): 10495-10503. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000306441100023&KeyUID=WOS:000306441100023.
    10.1021/la301181b
  29. Gentile, Luigi; Silva, Bruno F. B.; Balog, Sandor; Mortensen, Kell; Olsson, Ulf. "Structural transitions induced by shear flow and temperature variation in a nonionic surfactant/water system". Journal of Colloid and Interface Science 372 (2012): 32-39. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000301320300005&KeyUID=WOS:000301320300005.
    10.1016/j.jcis.2012.01.027
  30. Silva, Bruno F. B.; Marques, Eduardo F.; Olsson, Ulf; Paul, BK; Moulik, SP. "Unusual Phase Behavior in a Two-Component System Catanionic Surfactant-Water: From Lamellar-Lamellar to Vesicle-Micelle Coexistence". Recent Trends in Surface and Colloid Science 12 (2012): 69-84. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000320922700006&KeyUID=WOS:000320922700006.
  31. Silva, Bruno F. B.; Marques, Eduardo F.; Olsson, Ulf. "Aqueous phase behavior of salt-free catanionic surfactants: the influence of solubility mismatch on spontaneous curvature and balance of forces". Soft Matter 7 1 (2011): 225-236. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285360200030&KeyUID=WOS:000285360200030.
    10.1039/c0sm00477d
  32. Margulis-Goshen, Katrin; Silva, Bruno F. B.; Marques, Eduardo F.; Magdassi, Shlomo. "Formation of solid organic nanoparticles from a volatile catanionic microemulsion". Soft Matter 7 19 (2011): 9359-9365. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000295085700082&KeyUID=WOS:000295085700082.
    10.1039/c1sm05637a
  33. Silva, Bruno F. B.; Marques, Eduardo F.; Olsson, Ulf. "Fusion and fission of catanionic bilayers". Soft Matter 7 5 (2011): 1686-1689. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000287588800021&KeyUID=WOS:000287588800021.
    10.1039/c0sm01269f
  34. Fernandes, Ricardo M. F.; Marques, Eduardo F.; Silva, Bruno F. B.; Wang, Yujie. "Micellization behavior of a catanionic surfactant with high solubility mismatch Composition, temperature, and salt effects". Journal of Molecular Liquids 157 2-3 (2010): 113-118. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285234500004&KeyUID=WOS:000285234500004.
    10.1016/j.molliq.2010.08.014
  35. Silva, Bruno F. B.; Marques, Eduardo F.; Olsson, Ulf; Pons, Ramon. "Headgroup Effects on the Unusual Lamellar-Lamellar Coexistence and Vesicle-to-Micelle Transition of Salt-Free Catanionic Amphiphiles". Langmuir 26 5 (2010): 3058-3066. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000274636900016&KeyUID=WOS:000274636900016.
    10.1021/1a902963k
  36. Silva, Bruno F. B.; Marques, Eduardo F.; Olsson, Ulf; Linse, Per. "Size, Shape, and Charge of Salt-Free Catanionic Microemulsion Droplets: A Small-Angle Neutron Scattering and Modeling Study". Journal of Physical Chemistry B 113 30 (2009): 10230-10239. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000268231000027&KeyUID=WOS:000268231000027.
    10.1021/jp901752s
  37. Silva, Bruno F. B.; Marques, Eduardo F.; Olsson, Ulf. "Unusual vesicle-micelle transitions in a salt-free catanionic surfactant: Temperature and concentration effects". Langmuir 24 19 (2008): 10746-10754. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000259673500038&KeyUID=WOS:000259673500038.
    10.1021/la801548s
  38. Silva, Bruno F. B.; Marques, Eduardo F.; Olsson, Ulf. "Lamellar miscibility gap in a binary catanionic surfactant-water system". Journal of Physical Chemistry B 111 48 (2007): 13520-13526. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000251291600008&KeyUID=WOS:000251291600008.
    10.1021/jp076321f
  39. Marques, EF; Brito, RO; Wang, YJ; Silva, BFB. "Thermotropic phase behavior of triple-chained catanionic surfactants with varying headgroup chemistry". Journal of Colloid and Interface Science 294 1 (2006): 240-247. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000233863500028&KeyUID=WOS:000233863500028.
    10.1016/j.jcis.2005.07.021
  40. Fernandes, PA; Maia, ARR; Almeida, AAS; Silva, BFB; Ribeiro, CMS; Ribeiro, CFB; Ribeiro, DSM; et al. "New designs for inhibitors of the NF-kappa B: DNA binding". Theoretical Chemistry Accounts 113 4 (2005): 197-204. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000228895500001&KeyUID=WOS:000228895500001.
    10.1007/s00214-005-0628-1
  41. Silva, BFB; Marques, EF. "Thermotropic behavior of asymmetric chain length catanionic surfactants: The influence of the polar head group". Journal of Colloid and Interface Science 290 1 (2005): 267-274. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000231680700033&KeyUID=WOS:000231680700033.
    10.1016/j.jcis.2005.04.012
  42. Fernandes, PA; Cruz, AIS; Maia, ARR; Almeida, AAS; da Silva, AMN; Silva, BFB; Ribeiro, CMS; et al. "Design of 2-cyclopentenone derivatives with enhanced NF-kappa B: DNA binding inhibitory properties". Journal of Molecular Structure-Theochem 685 1-3 (2004): 73-82. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000225007900005&KeyUID=WOS:000225007900005.
    10.1016/j.theochem.2004.06.027
Pré-impressão
  1. Juan L Paris; Ricardo Gaspar; Filipe Coelho; Pieter De Beule; Bruno Silva. "Stability Criterion for the Assembly of Hybrid Lipid-Polymer-Nucleic Acid Nanoparticles". 2022. http://dx.doi.org/10.1101/2022.02.06.479316.
    10.1101/2022.02.06.479316
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/10/25 Illuminating the Complexity with X-rays, neutrons and light: Structural Insights into Self-Assembled Lipid Systems, from Microemulsions to Lipid-DNA Nanoassemblies Basel Campus Seminars, Novartis and Excelsus Structural Solutions, Basel, Switzerland
Novartis (Basel, Suiça)
2024/06 From Methodology to Insight: Unraveling the Assembly of Hybrid Core-Shell Bio-Inspired Polymer-Lipid Nanoparticles Biointerface Science - Gordon Research Conference
GRC (Lucca (Barga), Itália)
2024/05/28 Quantitative colocalization between nucleic acids, lipids & polymers with fluorescence cross-correlation spectroscopy Applied Biophysics Forum in Drug Delivery
University of Copenhagen | Malvern (Copenhagen, Dinamarca)
2024 Microfluidics with in-situ SAXS for time-resolved studies of liquid crystal dissolution Swiss Soft Days
Paul Scherrer Institute (Villigen, Suiça)
2023 Advancements and challenges in nonviral gene therapeutics: A physical chemist’s perspective International Meeting Molecules4Life
Universidade de Tras-os-Montes e Alto Douro (Vila Real, Portugal)
2023 A Criterion for Predicting Stable Assembly of Lipid-Polymer-Nucleic Acid Nanoparticles Controlled Release Society Annual Meeting & Exposition
CRS (Las Vegas, Estados Unidos)
2023 General assembly behavior of core- shell lipid-polycation-nucleic acid nanoparticles as revealed with fluorescence cross-correlation spectroscopy Swiss Soft Days
Adolphe Merkel Institute (Fribourg, Suiça)
2023 Microfluidics with in-situ SAXS for time-resolved studies of liquid crystal dissolution Annual Meeting Swiss Society for Crystallography
University of Zurich (Zurich, Suiça)
2020/06/28 Optimizing The Assembly Of Complex Gene Delivery Formulations With Fluorescence Cross Correlation Spectroscopy Controlled Release Society Virtual Annual Meeting
Controlled Release Society (Virtual, Estados Unidos)
2019/07/23 Size-controlled Formation Of Cubosome Nanoparticles Using Microfluidics Controlled Release Society Annual Meeting & Exposition
Controlled Release Society (Valencia, Espanha)
2019/07/18 Fluorescence Cross-Correlation Spectroscopy as a Valuable Tool to Monitor Cationic Liposome-DNA Nanoparticle Assembly 8th Iberian Meeting on Colloids and Interfaces-RICI8
Grupos de Colóides e Interfaces das Sociedades Portuguesa e Espanhola de Química (Aveiro, Portugal)
2019/07/17 Microfluidics for controlled self-assembly of cubosome nanoparticles of tunable size 8th Iberian Meeting on Colloids and Interfaces-RICI8
Grupos de Colóides e Interfaces das Sociedades Portuguesa e Espanhola de Química (Aveiro, Portugal)
2019/07/17 Pathway-dependent effects on the formation of bioreducible polycation-DNA polyplexes in saline media 8th Iberian Meeting on Colloids and Interfaces-RICI8
Grupos de Colóides e Interfaces das Sociedades Portuguesa e Espanhola de Química (Aveiro, Portugal)
2018/12/11 SAXS on a chip: from alignment phenomena at interfaces to dynamics of phase transitions studied with microfluidic devices Workshop - Scattering and Dynamics of Flowing Soft Material
Lund Institute of Advanced Neutron and X-ray Science (LINXS) (Lund, Suécia)
2018/09/07 SAXS on a chip: from alignment phenomena at interfaces to dynamics of phase transitions studied with microfluidic devices 32nd Conference of the European Colloid and Interface Society
European Colloid and Interface Society (Ljubljana, Eslovénia)
2018/05/29 SAXS-on-a-chip: probing the time evolution of the lamellar-microemulsion transition in a microfluidic device EUSMI/SoftComp Annual Meeting 2018
EUSMI and SoftComp (EU infrastructure networks) (Primosten, Croácia)
2018/03/13 Pathway-dependent effects in the complexation of DNA with PEGylated Cationic Liposomes Polyelectrolytes in Chemistry, Biology and Technology 2018
NTU - Nanyang Technological University, Singapore (Singapura, Singapura)
2017/07/07 Soft self-assembled nanostructured nanoparticles for gene and drug delivery VII Iberian Meeting of Colloids and Interface
Grupos de Colóides e Interfaces das Sociedades Espanhola e Portuguesa de Química (Madrid, Espanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023 - 2025/01/27 Elucidating Nano-scale Interactions Between Iron-carbohydrate Complexes and Complex Biological Environments Using Orthogonal Methods
Coorientador
Empa - Swiss Federal Laboratories for Materials Science and Technology, Suiça

Université de Fribourg Faculté de sciences et de médecine, Suiça

Empa Standort Sankt Gallen, Suiça
2020/12/01 - 2024/11/30 Innovative dual-drug loaded cubosomes to tackle Pseudomonas aeruginosa infections in cystic fibrosis airway environment
Coorientador
 Programa Doutoral Engenharia Biomédica (Doutoramento)
Universidade do Minho, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2020/11/01 - 2024/10/31 Chromene-based molecules for triple negative breast cancer therapy: synthesis, nanoencapsulation and biological studies
Coorientador
Universidade do Minho, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2019/10/01 - 2024/10/22 New Methods in Lipid-Based Nanosystems: From Microfluidic Mixing to Time-Resolved Quantification of PEG-Shedding in Lipid-Based Nanoparticles
Coorientador
 Física (MAP-FIS) (Doutoramento)
Universidade do Minho, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2018 - 2022 Nanomaterials for therapeutic purposes
Coorientador
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Minho, Portugal
2019/10/01 - 2021/05 Microfluidics as nanoassemblers of soft self-assembled nanocarriers for drug delivery
Coorientador
 Biofísica e Bionanossistemas (Mestrado)
Universidade do Minho, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2020/02/10 - 2020/08/25 Exploring Polycation-DNA complexation for gene delivery using Fluorescence Cross-Correlation Spectroscopy
Coorientador de Xhorxhina Shaulli
 Master in Chemistry from the University of Porto (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2018/11/06 - 2020/06/25 Monoolein cubosome formation using solvent-exchange in bulk and microfluidics: the effect of DODAB and DDAB addition
Coorientador de Maria Margarida da Silva Costa Barros
 Biofísica e Bionanossistemas (Mestrado)
Universidade do Minho, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2017/10/16 - 2019/03/11 Inhaled therapeutic strategies for cystic fybrosis-associated infections using nanoparticles-based drug delivery
Coorientador de Joana Margarida Dias Domingues
 Master in Biotechnology (Mestrado)
Universidade do Minho, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2017/10/02 - 2018/12/04 Microfluidic methods for the controlled preparation of soft self-assembled nanocarriers for drug delivery
Coorientador de Celso Joel Oliveira Ferreira
 Biofísica e Bionanossistemas (Mestrado)
Universidade do Minho, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2017/01/01 - 2017/11/17 Bulk and Microfluidic-Assisted Preparation of Bioreducible Polyplexes for Gene Therapy
Coorientador de Filipe Coelho
 Mestrado em Química (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

International Iberian Nanotechnology Laboratory, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2018/12/14 Microfluidic platforms for the validation of new targeted therapies for personalised medicine against osteosarcoma
Arguente principal
 Oihane Mitxelena (Doutoramento)
Centro de Estudios e Investigaciones Técnicas de Gipuzkoa, Espanha

Universidad de Navarra, Espanha
2018/01/31 Development and characterization of cellulose based systems for the entrapment and delivery of probiotic bacteria
Arguente
 Poonam Singh (Doutoramento)
Universidade de Coimbra, Portugal
2017/02/17 Combination of Microfluidics with SAXS for the investigation of pharmaceutical formulations
Arguente principal
 Aghiad Ghazal (Doutoramento)
Københavns Universitet Niels Bohr Instituttet, Dinamarca
Distinções

Outra distinção

2012 MRL-Dow travel fellowship
2010 AXA Research Fund Post-Doctoral Grants (recusei devido a conflito de datas com a bolsa Marie Curie IOF)
Fonds AXA pour la Recherche, França
2010 Marie Curie International Outgoing Fellowship
Research Executive Agency, Bélgica

European Commission, Bélgica
2009 Bolsa no estrangeiro de curta duração
Fundação Calouste Gulbenkian, Portugal
2005 Bolsa de Doutoramento
Fundação para a Ciência e a Tecnologia, Portugal