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Sónia Gonçalves is a senior researcher at the Biomembranes and Nanomedicine group led by Nuno C. Santos at the Institute of Molecular Medicine (iMM, since 2008) and a researcher at the Faculty of Medicine, University of Lisbon (2005). Sónia has a strong technical background in biophysics with applications in microbiology. The purpose of Sónia's research is to transpose scientific knowledge into medicinal applications to combat the widespread prevalence of infectious diseases. She has developed her research in the field of antimicrobials, in particular a new generation of antimicrobials isolated from animals and plants. Over the last 5 years, Sónia has focused on the study of the biochemical and biophysical processes that occur at the membrane level of human cells and bacterial pathogens. She has focused on four molecules as antimicrobial agents in bacterial cells. These peptides have shown enhanced inhibitory activity against some ESKAPE pathogens with alterations at the membrane level. She specializes in the examination of bacterial membranes, which help to understand the mechanisms that contribute to the development of antibiotic resistance and how diseases spread. In the field of nanotechnology/nanomedicine, Sónia has implemented the synthesis of star-shape nanoparticles and its conjugation with AMPs to improve its selectivity and sensitivity in combating resistant bacterial infections. At the same time, she studies the changes in mechanical properties induced by these small molecules in the bacterial membrane using techniques such as fluorescence, dynamic light scattering, confocal microscopy and atomic force microscopy (AFM). She is the Principal Investigator of an FCT-PEX founded project (FCT 2022.01991.PTDC; DOI 10.54499/2022.01991.PTDC), which aims to develop nano-based antimicrobial strategies to prevent prosthetic joint infections. She was also a team member of the BIOCOLOUR project (POCI-01-0247-FEDER-068924), which exploited microbial pigments for sustainable applications in textiles. At this moment Sónia participates as a team member in two founded projects: IMPLAT, the development of a single-cell platform to validate material scaffolds and drugs for the enhanced osteointegration of biomedical implants and COLOR2COAT (CI23-10134/La Caixa Foundation), development of nano-coatings for prosthetics based on microbial phenazines conjugated with silver nanostars. As a result, she has extensive knowledge of microbiology and analytical methods for characterizing microbial cells in biotech, environmental, and biomedical settings. During pandemics, Sónia participates in various national and international collaborative projects with industry to test the potentialities of UV light as antibacterial agent. She is (co-)author of more than 55 peer-reviewed publications, (co-)author of 2 book chapters, editor of 3 special issues (published by Wiley and Springer), oral communications, and 45 posters in international conferences. She has been a supervisor of Ph.D. and MSc theses. She works with foreign researchers in Brazil, Argentina, and Spain, as well as in Portugal at the Universidade de Aveiro and, more recently, the Universidade do Porto.
Identificação

Identificação pessoal

Nome completo
Sónia Gonçalves Abreu

Nomes de citação

  • Gonçalves, Sónia
  • Goncalves, Sonia

Identificadores de autor

Ciência ID
F811-74AE-412A
ORCID iD
0000-0003-2903-4282
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=Iaua62EAAAAJ&view_op=list_works&gmla=AC6lMd807Xydiwgh_9BB7Nvpk7kPFE3NrspIKTQGmtGu9gFxRhD-_8Pz3IANZOGIlmf3kzLrCjQBVpybdsRo-fgKnjpgf0o5w5aYS3Fkc95JfHiGk2BOM2ZEC3Wlwd1PsIWPZMHkpuRYfoAsH9kiDyw
Researcher Id
H-9482-2017
Scopus Author Id
35602210000

Domínios de atuação

  • Ciências Exatas - Química
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências Exatas - Química - Química Física
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências Naturais - Ciências Biológicas - Métodos de Investigação Bioquímica
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Exatas - Física - Ótica
  • Ciências Exatas - Física - Ótica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2003
Concluído
Philosophy (Doutoramento)
Especialização em Chemistry
Universidad Central de Venezuela-Facultad de Ciencias Básicas, Escuela de Química, Venezuela
"Spectroscopic study of Asphaltenes aggregation processes" (TESE/DISSERTAÇÃO)
n/a
1998
Concluído
n/a (Licenciatura)
Universidad Central de Venezuela, Facultad de Ciencias Básicas, Escuela de Química, Venezuela
"n/a" (TESE/DISSERTAÇÃO)
n/a
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2024/09/01 - Atual Investigador (Investigação) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2004/03/01 - Atual Investigador (Investigação) Universidade de Lisboa, Faculdade de Medicina de Lisboa, Instituto de Bioquímica, Portugal
Universidade de Lisboa, Faculdade de Medicina de Lisboa, Instituto de Bioquímica, Portugal
2008/01/01 - 2024/08/31 Investigador (Investigação) NSantos Lab (Biomembranes Unit), Instituto de Medicina Molecular (IMM), Lisboa, Portugal
2005 - 2008 Investigador (Investigação) Instituto de Medicina Molecular, Portugal
2004/04/01 - 2005/02/28 Investigador (Investigação) Instituto de Biopatologia Química, Faculdade de Medicina de Lisboa, Portugal
2002/10/01 - 2003/03/30 Investigador (Investigação) Universidade Central de Venezuela-Facultad de Ciencias Básicas, Escuela de Química, Venezuela
2002/01/01 - 2003/02/28 Investigador (Investigação) Universidad Central de Venezuela, Venezuela
Projetos

Bolsa

Designação Financiadores
2013/01/01 - Atual Strategic Project
UID/BIM/50005/2013
Investigador
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2011/01/01 - Atual Multi-target HIV entry inhibitors delivery by cationic liposomes (HIVERA)
VIH/SAU/0047/2011
Investigador
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2023/10 - 2025/10 COLOR2COAT: Nano-coatings for prosthetics based on microbial phenazines conjugated with silver nanostars (CI23-10134)
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Em curso
2023 - 2025 AMP-AgNP conjugates: the mutual reinforcement of antibacterial activity
2022.01991.PTDC
Investigador responsável
NSantos Lab (Biomembranes Unit), Instituto de Medicina Molecular (IMM), Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2024/01/01 - 2024/12/31 ImPlat: A single-cell platform to validate material scaffolds and drugs for the enhanced osteointegration of biomedical implants
IMPLAT
Research Team
Missão Interface – programa de financiamento base no âmbito do Plano de Recuperação e Resiliência (PRR) do Centro de Tecnologia e Inovação (CTI) do iMM
Em curso
2021/01/01 - 2023/12/31 BIOCOLOUR: Developing new biocolourants towards a sustainable dyeing of textiles. POCI-01-0247-FEDER-068924
POCI-01-0247-FEDER-068924
Outra
NSantos Lab (Biomembranes Unit), Instituto de Medicina Molecular (IMM), Lisboa, Portugal
Concluído
2014 - 2018 Broad-spectrum antiviral peptides against respiratory viruses. PTDC/BBB-BQB/3494/2014
PTDC/BBB-BQB/3494/2014
Investigador
Concluído
2014/01/01 - 2017/01/01 Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies.
PTDC/BBB-BMD/6307/2014
Investigador
Associação para a Inovação e Desenvolvimento da FCT
Concluído
2010/01/01 - 2014/01/01 Membrane-active peptides across disciplines and continents: An integrated approach to find new strategies to fight bactéria, dengue virus, and neurodegeneration.
MEMPEPACROSS
Investigador
Fundação para a Ciência e a Tecnologia
2010/01/01 - 2014/01/01 Employing amyloid fibrils as biosensors of the interaction of peptides with phospholipids and/or protein domains
PTDC/SAU-ENB/117013/2010
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2014/01/01 Characterization of the fibrinogen-erythrocyte interaction and its influence on Cardiovascular pathologies
PTDC/QUI-BIQ/119509/2010
Investigador
2007/01/01 - 2012/01/01 Fibrinogen-dependent signaling in microvascular blood cell function-Implications of inflammation and cardiovascular disease
PTDC/SAU-OSM/73449/2006
Investigador

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Instituto de Medicina Molecular João Lobo Antunes
LA/P/0082/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2011/01/01 - 2013/02/17 Strategic Project - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Investigador
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2006/01/01 - 2010/01/01 Identification of a marker for Alzheimer's disease therapy.
Fundação Merck Sharp Dohme/2007-2009
Investigador
Concluído
2006/01/01 - 2007/12/31 Effects of probiotics enriched yogurth on intestinal constipation : a randomized controlled trial
Lactogal-HON
Investigador
Concluído
2004/01/01 - 2007/12/31 Effects of phytosterols enriched milk in the biochemical, hematological and hemorheological parameters of healthy and hypercholesterolemic subjects: a randomized controlled trial
Lactogal-HNF
Investigador
Concluído

Outro

Designação Financiadores
2007/01/01 - 2010 BDNF and TrKB receptors quantification in depress and bipolar patients
AIDFM-Associação para Investigação e Desenvolvimento da Faculdade de Medicina de Lisboa.
Investigador
MSD Portugal
Concluído
Produções

Publicações

Artigo em conferência
  1. Hung, Jannett; Castillo, Jimmy A.; Goncalves Abreu, Sonia; Fernandez, Alberto. "Aggregation process of asphaltenes in a Venezuelan crude oil using Confocal Microscopy". 2003.
    10.1117/12.526957
Artigo em revista
  1. Liana Costa Pereira Vilas Boas; Danieli Fernanda Buccini; Rhayfa Lorrayne Araújo Berlanda; Bruno de Paula Oliveira Santos; Mariana Rocha Maximiano; Luciano Morais Lião; Sónia Gonçalves; Nuno C. Santos; Octávio Luiz Franco. "Antiviral Activities of Mastoparan-L-Derived Peptides against Human Alphaherpesvirus 1". Viruses (2024): https://doi.org/10.3390/v16060948.
    10.3390/v16060948
  2. Costa, Igor S. D.; Junot, Tiago; Silva, Fernanda L.; Felix, Wanessa; Cardozo Fh, José L.; Pereira de Araujo, Antonio F.; Pais do Amaral, Constança; et al. "Occurrence and evolutionary conservation analysis of a-helical cationic amphiphilic segments in the human proteome". The FEBS Journal (2023): http://dx.doi.org/10.1111/febs.16997.
    Publicado • 10.1111/febs.16997
  3. Sónia Gonçalves; Nuno C. Santos. "Membrane-Peptide Interactions: From Basics to Current Applications 2.0". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24087202.
    10.3390/ijms24087202
  4. Sónia Gonçalves; Ivo C. Martins; Nuno C. Santos. "Nanoparticle-peptide conjugates for bacterial detection and neutralization: Potential applications in diagnostics and therapy". WIREs Nanomedicine and Nanobiotechnology (2022): https://doi.org/10.1002/wnan.1819.
    10.1002/wnan.1819
  5. Barbosa, Joana C.; Gonçalves, Sónia; Makowski, Marcin; Silva, Ítala C.; Caetano, Tânia; Schneider, Tanja; Mösker, Eva; et al. Autor correspondente: Mendo, Sónia. "Insights into the mode of action of the two-peptide lantibiotic lichenicidin". Colloids and Surfaces B: Biointerfaces 211 (2022): 112308. http://dx.doi.org/10.1016/j.colsurfb.2021.112308.
    10.1016/j.colsurfb.2021.112308
  6. Barbosa, Joana C.; Silva, Ítala C.; Caetano, Tânia; Mösker, Eva; Seidel, Maria; Lourenço, Joana; Süssmuth, Roderich D.; et al. Autor correspondente: Mendo, Sónia. "Assessing the potential of the two-peptide lantibiotic lichenicidin as a new generation antimicrobial". World Journal of Microbiology and Biotechnology 38 1 (2022): http://dx.doi.org/10.1007/s11274-021-03196-y.
    Publicado • 10.1007/s11274-021-03196-y
  7. Sónia Gonçalves. "An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold". Chemical Science 13 32 (2022): 9410-9424. http://dx.doi.org/10.1039/d1sc06998e.
    10.1039/d1sc06998e
  8. Felício, Mário R; Silveira, Gislaine G O S; Oshiro, Karen G N; Meneguetti, Beatriz T; Franco, Octávio L; Santos, Nuno C; Gonçalves, Sónia. "Polyalanine peptide variations may have different mechanisms of action against multidrug-resistant bacterial pathogens". Journal of Antimicrobial Chemotherapy (2021): http://dx.doi.org/10.1093/jac/dkaa560.
    10.1093/jac/dkaa560
  9. Aguiar, Francisca Lidiane Linhares de; Santos, Nuno C.; de Paula Cavalcante, Carolina Sidrim; Andreu, David; Baptista, Gandhi Radis; Gonçalves, Sónia. "Antibiofilm Activity on Candida albicans and Mechanism of Action on Biomembrane Models of the Antimicrobial Peptide Ctn[15–34]". International Journal of Molecular Sciences 21 21 (2020): 8339. http://dx.doi.org/10.3390/ijms21218339.
    10.3390/ijms21218339
  10. Marcin Makowski; Mário R. Felício; Isabel C. M. Fensterseifer; Octavio Franco; Nuno C. Santos; Sónia Gonçalves. "EcDBS1R4, an Antimicrobial Peptide Effective against Escherichia coli with In Vitro Fusogenic Ability". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/23/9104.
    10.3390/ijms21239104
  11. Maturana, Patricia; Gonçalves, Sónia; Martinez, Melina; Espeche, Juan C.; Santos, Nuno C.; Semorile, Liliana; Maffia, Paulo C.; Hollmann, Axel. Autor correspondente: Hollmann, Axel. "Interactions of “de novo” designed peptides with bacterial membranes: Implications in the antimicrobial activity". Biochimica et Biophysica Acta (BBA) - Biomembranes 1862 11 (2020): 183443. http://dx.doi.org/10.1016/j.bbamem.2020.183443.
    10.1016/j.bbamem.2020.183443
  12. Abreu, Sónia. "Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery". Pharmaceutics (2019): http://dx.doi.org/10.3390/pharmaceutics11110588.
    10.3390/pharmaceutics11110588
  13. Abreu, Sónia. "Selective antibacterial activity of the cationic peptide PaDBS1R6 against Gram-negative bacteria". Biochimica et Biophysica Acta (BBA) - Biomembranes (2019): http://dx.doi.org/10.1016/j.bbamem.2019.03.016.
    10.1016/j.bbamem.2019.03.016
  14. Abreu, Sónia. "Synergistic and antibiofilm activity of the antimicrobial peptide P5 against carbapenem-resistant Pseudomonas aeruginosa". Biochimica et Biophysica Acta (BBA) - Biomembranes (2019): http://dx.doi.org/10.1016/j.bbamem.2019.05.008.
    10.1016/j.bbamem.2019.05.008
  15. Abreu, Sónia. "Studies on interaction of green silver nanoparticles with whole bacteria by surface characterization techniques". Biochimica et Biophysica Acta (BBA) - Biomembranes (2019): http://dx.doi.org/10.1016/j.bbamem.2019.03.011.
    10.1016/j.bbamem.2019.03.011
  16. Abreu, Sónia. "Psd2 pea defensin shows a preference for mimetic membrane rafts enriched with glucosylceramide and ergosterol". Biochimica et Biophysica Acta (BBA) - Biomembranes (2019): http://dx.doi.org/10.1016/j.bbamem.2018.12.020.
    10.1016/j.bbamem.2018.12.020
  17. Abreu, Sónia. "Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide". Biochimica et Biophysica Acta (BBA) - Biomembranes (2019): http://dx.doi.org/10.1016/j.bbamem.2018.08.001.
    10.1016/j.bbamem.2018.08.001
  18. Carvalho, Patrícia M.; Felício, Mário R.; Santos, Nuno C.; Gonçalves, Sónia; Domingues, Marco M.. "Application of Light Scattering Techniques to Nanoparticle Characterization and Development". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00237.
    10.3389/fchem.2018.00237
  19. Bravo-Ferrada, Bárbara Mercedes; Gonçalves, Sónia; Semorile, Liliana; Santos, Nuno C.; Brizuela, Natalia S.; Elizabeth Tymczyszyn, E.; Hollmann, Axel. "Cell surface damage and morphological changes in Oenococcus oeni after freeze-drying and incubation in synthetic wine". Cryobiology 82 (2018): 15-21. http://dx.doi.org/10.1016/j.cryobiol.2018.04.014.
    10.1016/j.cryobiol.2018.04.014
  20. Gomes, Bárbara; Gonçalves, Sónia; Disalvo, Anibal; Hollmann, Axel; Santos, Nuno C.. "Effect of 25-hydroxycholesterol in viral membrane fusion: Insights on HIV inhibition". Biochimica et Biophysica Acta (BBA) - Biomembranes 1860 5 (2018): 1171-1178. http://dx.doi.org/10.1016/j.bbamem.2018.02.001.
    10.1016/j.bbamem.2018.02.001
  21. Gomes, Bárbara; Augusto, Marcelo T.; Felício, Mário R.; Hollmann, Axel; Franco, Octávio L.; Gonçalves, Sónia; Santos, Nuno C.. "Designing improved active peptides for therapeutic approaches against infectious diseases". Biotechnology Advances 36 2 (2018): 415-429. http://dx.doi.org/10.1016/j.biotechadv.2018.01.004.
    10.1016/j.biotechadv.2018.01.004
  22. Abreu, Sónia. "Psd1 Effects on Candida albicans Planktonic Cells and Biofilms". Frontiers in Cellular and Infection Microbiology (2017): http://dx.doi.org/10.3389/fcimb.2017.00249.
    10.3389/fcimb.2017.00249
  23. Felício MR; Silva ON; Gonçalves S; Santos NC; Franco OL. "Peptides with Dual Antimicrobial and Anticancer Activities.". (2017): http://europepmc.org/abstract/med/28271058.
    10.3389/fchem.2017.00005
  24. Migliolo L; Felício MR; Cardoso MH; Silva ON; Xavier MA; Nolasco DO; de Oliveira AS; et al. "Structural and functional evaluation of the palindromic alanine-rich antimicrobial peptide Pa-MAP2.". (2016): http://europepmc.org/abstract/med/27063608.
    10.1016/j.bbamem.2016.04.003
  25. Ribeiro SM; Felício MR; Boas EV; Gonçalves S; Costa FF; Samy RP; Santos NC; Franco OL. "New frontiers for anti-biofilm drug development.". (2016): http://europepmc.org/abstract/med/26896562.
    10.1016/j.pharmthera.2016.02.006
  26. Cardoso MH; Ribeiro SM; Nolasco DO; de la Fuente-Núñez C; Felício MR; Gonçalves S; Matos CO; et al. "A polyalanine peptide derived from polar fish with anti-infectious activities.". (2016): http://europepmc.org/abstract/med/26916401.
    10.1038/srep21385
  27. Cardoso MH; Ribeiro SM; Nolasco DO; de la Fuente-Núñez C; Felício MR; Gonçalves S; Matos CO; et al. "Corrigendum: A polyalanine peptide derived from polar fish with anti-infectious activities.". (2016): http://europepmc.org/abstract/med/27435893.
    10.1038/srep28216
  28. Goncalves, Sonia; Silva, Patricia M.; Felicio, Mario R.; de Medeiros, Luciano N.; Kurtenbach, Eleonora; Santos, Nuno C.. "PSD1 Antimicrobial Activity Against Candida Albicans Planktonic Cells and Biofilms". Biophysical Journal 110 3 (2016): 417A-417A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375142700037&KeyUID=WOS:000375142700037.
  29. Felicio, Mario R.; Franco, Octavio L.; Cardoso, Marlon H.; Migliolo, Ludovico; Santos, Nuno C.; Goncalves, Sonia. "Pa-MAP 1.5 and 1.9: Mechanisms of Action of two Antimicrobial Peptides". Biophysical Journal 110 3 (2016): 78A-78A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375093500403&KeyUID=WOS:000375093500403.
  30. Hollmann A; Gonçalves S; Augusto MT; Castanho MA; Lee B; Santos NC. "Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture.". (2015): http://europepmc.org/abstract/med/25791807.
    10.1016/j.nano.2015.02.014
  31. Bravo-Ferrada BM; Gonçalves S; Semorile L; Santos NC; Tymczyszyn EE; Hollmann A. "Study of surface damage on cell envelope assessed by AFM and flow cytometry of Lactobacillus plantarum exposed to ethanol and dehydration.". (2015): http://europepmc.org/abstract/med/25766880.
    10.1111/jam.12796
  32. Viana, Juliane F. C.; Carrijo, Jessica; Freitas, Camila G.; Paul, Arghya; Alcaraz, Jarib; Lacorte, Cristiano C.; Migliolo, Ludovico; et al. "Antifungal nanofibers made by controlled release of sea animal derived peptide". Nanoscale 7 14 (2015): 6238-6246. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351934700037&KeyUID=WOS:000351934700037.
    10.1039/c5nr00767d
  33. Silva, Patricia M.; Goncalves, Sonia; Santos, Nuno C.; Abreu, Sónia. "Defensins: antifungal lessons from eukaryotes". Frontiers in Microbiology 5 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333211000001&KeyUID=WOS:000333211000001.
    10.3389/fmicb.2014.00097
  34. Hollmann, Axel; Augusto, Marcelo T.; Goncalves, Sonia; Vigant, Frederic; Castanho, Miguel A. R. B.; Lee, Benhur; Santos, Nuno C.. "New Broad-Spectrum Viral Fusion Inhibitors Act by Deleterious Effect on the Viral Membrane through the Production Singlet Oxygen Molecules". Biophysical Journal 106 2 (2014): 708A-708A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337000404045&KeyUID=WOS:000337000404045.
  35. Gonçalves, S.; Abade, J.; Teixeira, A.; Santos, N.C.. "Lipid composition is a determinant for human defensin HNP1 selectivity.". Biopolymers 98 4 (2012): 313-321. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872050769&partnerID=MN8TOARS.
  36. Gonçalves, S.; Teixeira, A.; Abade, J.; De Medeiros, L.N.; Kurtenbach, E.; Santos, N.C.. "Evaluation of the membrane lipid selectivity of the pea defensin Psd1". Biochimica et Biophysica Acta - Biomembranes 1818 5 (2012): 1420-1426. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858719394&partnerID=MN8TOARS.
    10.1016/j.bbamem.2012.02.012
  37. Carvalho, F.A.; de Oliveira, S.; Freitas, T.; Gonçalves, S.; Santos, N.C.. "Variations on fibrinogen-erythrocyte interactions during cell aging". PLoS ONE 6 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953147017&partnerID=MN8TOARS.
    10.1371/journal.pone.0018167
  38. Matos, P.M.; Gonçalves, S.; Santos, N.C.. "Interaction of peptides with biomembranes assessed by potential-sensitive fluorescent probes". Journal of Peptide Science 14 4 (2008): 407-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149117742&partnerID=MN8TOARS.
    10.1002/psc.1005
  39. Gonçalves, S.; Santos, N.C.; Martins-Silva, J.; Saldanha, C.. "Fluorescence spectroscopy evaluation of fibrinogen-ß-estradiol binding". Journal of Photochemistry and Photobiology B: Biology 86 2 (2007): 170-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845567319&partnerID=MN8TOARS.
    10.1016/j.jphotobiol.2006.09.001
  40. Gonçalves, S.; Maria, A.V.; Silva-Herdade, A.S.; Martins e Silva, J.; Saldanha, C.. "Milk enriched with phytosterols reduces plasma cholesterol levels in healthy and hypercholesterolemic subjects". Nutrition Research 27 4 (2007): 200-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047273054&partnerID=MN8TOARS.
    10.1016/j.nutres.2007.03.003
  41. Saldanha, C.; Silva, A.S.; Gonçalves, S.; Martins-Silva, J.. "Modulation of erythrocyte hemorheological properties by band 3 phosphorylation and dephosphorylation". Clinical Hemorheology and Microcirculation 36 3 (2007): 183-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249881040&partnerID=MN8TOARS.
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Capítulo de livro
  1. Abreu, Sónia. "Antimicrobial Peptides: Effect on Bacterial Cells". 2019.
    10.1007/978-1-4939-8894-5_13
Edição de livro
  1. Gonçalves, Sónia. Membrane-Peptide Interactions: From Basics to Current Applications. Basel, Suiça: IJMS. 2020.
    Aceite para publicação • 10.1016/s0070-2161(08)x6010-1 • Editor

Outros

Outra produção
  1. Synergistic Effects of Antimicrobial Peptides in Overcoming Resistance. Research Topic titled for Antimicrobials, Resistance and Chemotherapy section in Frontiers in Microbiology. 2024. Ciobanasu ; Gonçalves, Sónia; Berthony Deslouches. https://www.frontiersin.org/research-topics/56876/synergistic-effects-of-antimicrobial-peptides-in-overcoming-resistance.
  2. Design, Modification and Application of Antimicrobial Peptides. A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".. 2023. Gonçalves, Sónia; Monteiro, Cláudia; Pereira, Ana Margarida; Soares-Castro, Pedro. https://www.mdpi.com/journal/antibiotics/special_issues/Peptide_design.
  3. Membrane–Peptide Interactions: From Basics to Current Applications. Special Issue in International Journal of Molecular Science.. 2022. Santos, NunoC; Gonçalves, Sónia. https://www.mdpi.com/journal/ijms/special_issues/Membrane_Peptide2.
  4. Research on Bacterial Cell Membranes. A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Functions".. 2022. Gonçalves, Sónia; Cardoso, Marlon H.. https://www.mdpi.com/journal/membranes/special_issues/bacterial_cell_memb.
  5. Membrane–Peptide Interactions: From Basics to Current Applications. A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".. 2021. Gonçalves, Sónia; Santos, Nuno C.. https://www.mdpi.com/journal/ijms/special_issues/Membrane_Peptide.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2018/01/30 Drug resistance in bacterial cells: biophysical characterization of peptide-membrane interactions-techniques to approach LisbonBiomed PhD Program week
Instituto de Medicina Molecular (Lisbon, Portugal)
2017/07 PaMAP´s analogs: antimicrobial peptides with anticancer activities. 1º Encontro A Química na Investigação da ULisboa
Colégio de Química, Universidade de Lisboa (Lisbon, Portugal)
2017/01/31 Drug resistance in bacterial cells: biophysical characterization of peptide-membrane interactions LisbonBiomed PhD Program week
Instituto de Medicina Molecular (Lisbon, Portugal)
2013/08/22 Lipid membrane: models as tools to study peptide-lipid interactions.
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (Rio de Janeiro, Brasil)
2012/07/04 Variations on fibrinogen-erythrocyte interactions during cell aging. XXII International Fibrinogen Wokshop. Biennial Meeting of the International Society on Fibrinogen Research (IFRS).
(Brighton, Reino Unido)
2009/07/01 Fibrinogen and erythrocyte membrane interaction: potential binding sites evaluation. 15th Conference of the European Society for Clinical Hemorheology and Microcirculation (ESCHM)
(St. Moritz, Suiça)
2007/09/19 Antioxidant Capacity and Aged Related Macular Degeneration. 7th International Conference Vitamins 2007: Nutrition and Diagnostics.
(Prague, República Checa)
2007/09/19 Antioxidant capacity and aged related macular degeneration. 7th International Conference Vitamins 2007: Nutrition and Diagnostics.
(Prague, República Checa)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/09/01 - 2024/10/31 Synthetic antimicrobial peptides to fight S. aureus biofilms.
Orientador
Masther in Medicine (Mestrado)
Instituto de Bioquímica, Faculdade de Medicina de Lisboa, Portugal
2023/09 - 2024/10 Exploring the biomedical potential of bacterial pigments towards antimicrobial solutions against human pathogens
Coorientador
Master in Biochemistry (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/03 - 2024/06 Antimicrobial and anticancer activities of peptide-conjugated nanoparticles. Peptide-conjugated nanoparticles as alternative approach in antimicrobial and anticancer therapies
Orientador
Doctor (Doutoramento)
NSantos Lab (Biomembranes Unit), Instituto de Medicina Molecular (IMM), Lisboa, Portugal
2022/09/01 - 2024/01/05 Antibiofilm effect of synthetic antimicrobial peptides on Gram-positive and Gram-negative bacteria
Orientador
Microbiologia Aplicada (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/06/01 - 2024 Peptides and collagen regulation: how to overcome skin aging.
Orientador
Investigação Biomédica (Mestrado)
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2022/09/01 - 2023/11/15 Towards antimicrobial solutions against human pathogens by exploiting the biotechnological potential of microbial pigments.
Orientador
TECNOLOGIAS CLÍNICO-LABORATORIAIS (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2022/09/01 - 2023/10/22 Harnessing the biomedical potential of bacterial pigments to develop antimicrobial solutions against multidrug-resistant pathogens.
Coorientador
Clinical-Laboratory Technologies (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2020/09/01 - 2022/02/28 Antimicrobial activity of peptide PaDBS1R3 against Gram-negative bacteria.
Orientador
Biomedical Engneering (Mestrado)
Associação para a Inovação e Desenvolvimento da FCT, Portugal
2020/09/01 - 2022/02/28 Antibiofilm effect of de novo-designed antimicrobial peptides
Orientador
Microbiologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 - 2022 Antimicrobial activity of peptide PaDBS1R3 against Gram-negative bacteria
Orientador
Master in Biomedical Engeenering (Mestrado)
Universidade Nova de Lisboa, Portugal
2020 - 2022 Antibiofilm effect of de novo-designed antimicrobial peptides
Orientador
Master in Microbiology (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/03 - 2021/06 Design and mechanistic characterization of novel antimicrobial and anticancer peptides
Orientador
Doctor in Biomedical Sciences (Doutoramento)
Universidade de Lisboa, Portugal
2015/09/01 - 2021 Design and mechanistic characterization of novel antimicrobial and anticancer peptides
Orientador
Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/09/01 - 2016/12/15 Mechanism of action and membrane selectivity of a novel antimicrobial peptide
Orientador
Microbiologia Aplicada (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - 2016 Mechanism of action and membrane selectivity of a novel antimicrobial peptide
Orientador
Master in Applied Microbiology (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/01/01 - 2015/12/31 Molecular interactions of circulating fibrinogen as a risk factor for cardiovascular and cerebrovascular pathologies.
Orientador
Instituto de Medicina Molecular, Portugal
2012/01/01 - 2013/12/31 Employing amyloid fibrils as biosensors of the interaction of peptides with phospholipids and/or protein domains
Coorientador
Instituto de Medicina Molecular, Portugal
2009/05/01 - 2010/12/31 HNP1 as antimicrobial peptide
Orientador
Instituto de Bioquímica, Faculdade de Medicina de Lisboa, Portugal
2007/01/01 - 2010/12/31 Degeneração Macular em Doentes de Avançada Idade
Coorientador de Ana Sofia Pereira Hernandes
Master Degree (Licenciatura/Bacharelato)
Instituto de Bioquímica, Faculdade de Medicina de Lisboa, Portugal
2008/05/01 - 2009/12/31 Psd1 as antimicrobial peptide
Orientador
Instituto de Bioquímica, Faculdade de Medicina de Lisboa, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019/07/16 - 2019/07/18 4º ECQUL – Chemistry Shaping the Future & Summer School 2019 (2019/07/16 - 2019/07/18)
Conferência (Membro da Comissão Organizadora)
Colégio de Química, Portugal
2018/06 - 2018/06 3º ECQUL_CHEMISTRY AT ULISBOA & 2018 SUMMER SCHOOL (2018/06 - 2018/06)
Conferência (Membro da Comissão Organizadora)
Colégio de Química, Portugal
2017/08 - 2017/12 2º ECQULUL-Chemistry PhD Meeting (2017/12/04 - 2017/12/05)
Conferência (Membro da Comissão Organizadora)
Colégio de Química, Portugal
2017/03 - 2017/06 1º ECQUL-A Química na Investigação da ULisboa (2017/06 - 2017/06)
Conferência (Membro da Comissão Organizadora)
Colégio de Química, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019/07/16 - 2019/07/18 4º ECQUL – Chemistry Shapping the Future & Summer School 2019 Reitoria, Universidade de Lisboa
2018/06/27 - 2018/06/29 3º ECQUL_CHEMISTRY AT ULISBOA & 2018 SUMMER SCHOOL Reitoria, Universidade de Lisboa
2017/12/04 - 2017/12/05 2º ECQULUL-Chemistry PhD Meeting Reitoria, Universidade de Lisboa
2017/07/20 - 2017/07/21 1º ECQUL-A Química na Investigação da ULisboa Reitoria, Universidade de Lisboa

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2010 - 2024/12/31 Animals; Chemistry - An Asian Journal; BBA - Biomembranes; ; Biochimie; Toxics; Journal of Fluorescence; Electronic Journal of BiotechnologyArchives of Biochemistry and Biophysics.

Tutoria

Tópico Nome do aluno
2017/01/01 - 2019/12/31 Supervisor of GAPIC fellowship André Antunes Miranda
2010/01/01 - 2011/12/31 Supervisor of GAPIC fellowship Teresa Prior Filipe
2008/01/01 - 2009/12/31 Supervisor of GAPIC fellowship Maria Luis Sacras
2008/01/01 - 2009/12/31 Supervisor of GAPIC fellowship Cláudia Antunes Penetra
Distinções

Prémio

1998 Conicit-Best Cientific Work in Chemistry
Consejo Nacional de Investigaciones Cientificas y Tecnologicas, Venezuela