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Tiago Gil Oliveira was a student in the joint MD/PhD program of the University of Minho, Portugal and Columbia University, NYC, USA. He performed his PhD studies at Columbia University, between 2007 and 2010, under the supervision of Prof. Gilbert Di Paolo and co-supervision by Prof. Nuno Sousa, and his MD studies at University of Minho. While studying the role of lipid signaling in Alzheimer’s disease pathogenesis, he showed that the ablation of the lipid-modulating enzyme, phospholipase D2, was protective in different Alzheimer’s disease models. In 2011 he started his post-graduate studies as Assistant Professor at the School of Medicine, University of Minho, where he teaches Anatomy to medical students. While in Minho he expanded his research interests to the study of mood disorders. Using an unbiased lipidomic approach, he showed that specific lipid signaling pathways were altered in a chronic stress model, unraveling new potential therapeutic targets. In parallel with his academic work he continued his medical career. He is currently a Neuroradiologist at Hospital de Braga and he is now using lipidomic approaches associated with brain imaging to study neurodegenerative diseases.
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Identificação

Identificação pessoal

Nome completo
Tiago Gil Oliveira

Nomes de citação

  • Oliveira, Tiago Gil

Identificadores de autor

Ciência ID
FB19-641C-5859
ORCID iD
0000-0003-0509-0562

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Patologia
  • Ciências Médicas e da Saúde - Medicina Básica - Patologia
  • Ciências Médicas e da Saúde - Medicina Clínica - Radiologia, Medicina Nuclear e Imagens Médicas
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2013/01/01 - 2018/04/17
Concluído
 Especialidade Médica em Neurorradiologia (Título de especialista)
Hospital de Braga, Portugal
 19.3
2011
Concluído
 LICENCIATURA EM MEDICINA COM MESTRADO INTEGRADO (Curso de Especialização Tecnológica)
Universidade do Minho Escola de Medicina, Portugal
"N/A" (TESE/DISSERTAÇÃO)
 16
2010
Concluído
 Medicina (Doutoramento)
Especialização em Especialidade: Medicina
Universidade do Minho, Portugal
"The Role Phospholipase D2 in Alzheirmer`s Disease" (TESE/DISSERTAÇÃO)
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/09/01 - Atual Professor Associado (Docente Universitário) Universidade do Minho, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/01/01 - 2022/09/01 Professor Auxiliar (Docente Universitário) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011 - 2020/01/01 Professor Auxiliar Convidado (Docente Universitário) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/04/18 - Atual Neuroradiologist Hospital de Braga, Portugal
2013/01/01 - 2018/04/17 Neuroradiology Resident Hospital de Braga, Portugal
2012/01/01 - 2012/12/31 General Resident Hospital de Braga, Portugal
2002/09/01 - 2011/07/01 Medical Student - MD/PhD program Universidade do Minho, Portugal
2007/09/01 - 2010/12/07 PhD student - MD/PhD program Columbia University, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2023/03/01 - 2026/02/28 The role of phospholipase D2 in Alzheimer’s disease
2022.05366.PTDC
Investigador responsável
Fundação para a Ciência e a Tecnologia, Portugal
Em curso
2023/01/01 - 2024/12/31 Brain imaging determinants of Alzheimer’s disease neuropathology
-
Investigador responsável
Fundação Amélia de Mello, Portugal
Em curso
2021/03 - 2023/02 Studying the differential impact of chronic stress on the longitudinal hippocampal axis by MRI
29817/20
 Brain and Behavior Research Foundation
2020/01/01 - 2021/12/31 The role of interneurons in spatial memory
320/18
Investigador responsável
Universidade do Minho, Portugal
 Fundação Bial
Em curso
2015/04 - 2017/09 The impact of lipid signaling modulation in cognition
253/14
 Fundação Bial

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
10.54499/LA/P/0050/2020
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2017/02/01 - 2021/04/30 Redes sinápticas e abordagens compreensivas de medicina personalizada em doenças neurocomportamentais ao longo da vida
SAICTPAC/0010/2015
Universidade de Aveiro, Portugal

Universidade do Minho, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2012/05/06 - 2015/10/05 A influência de interacções neurónio-glia na progressão de patologias induzidas pelo stress
PTDC/SAU-NSC/118194/2010
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/04/01 - 2015/07/31 The role of brain lipid metabolism in the modulation of chronic stress effects
PTDC/SAU-NMC/118971/2010
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 26 - 2011-2012
PEst-C/SAU/LA0026/2011
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2012/04/01 - 2015/08/31 Deciphering the role of Aβ and TAU among neuronal subpopulations in Alzheimer´s disease network malfunction.
PTDC/SAU-NSC/120590/2010
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Francisco C. Almeida; Kalicharan Patra; Andreas Giannisis; Anezka Niesnerova; Renu Nandakumar; Ewa Ellis; Tiago Gil Oliveira; Henrietta M. Nielsen. "APOE genotype dictates lipidomic signatures in primary human hepatocytes". Journal of Lipid Research (2024): https://doi.org/10.1016/j.jlr.2024.100498.
    10.1016/j.jlr.2024.100498
  2. Ferreira, J.P.; Leite-Moreira, A.; da Costa-Pereira, A.; Soares, A.J.; Robalo-Cordeiro, C.; Jerónimo, C.; Gavina, C.; et al. "Investigator-Led Clinical Research in Portugal: Problem Identification and Proposals for Improvement,Investigação Clínica da Iniciativa do Investigador em Portugal: Identificação de Problemas e Propostas para Melhoria". Acta Medica Portuguesa 36 5 (2023): 305-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-85159552183&partnerID=MN8TOARS.
    10.20344/amp.19333
  3. Pinho, J.; Almeida, F.C.; Araújo, J.M.; Machado, Á.; Costa, A.S.; Silva, F.; Francisco, A.; et al. "Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia". AJNR. American journal of neuroradiology 44 7 (2023): 792-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-85164624844&partnerID=MN8TOARS.
    10.3174/ajnr.A7900
  4. Calafate, S.; Özturan, G.; Thrupp, N.; Vanderlinden, J.; Santa-Marinha, L.; Morais-Ribeiro, R.; Ruggiero, A.; et al. "Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease". Nature Neuroscience 26 6 (2023): 1021-1031. http://www.scopus.com/inward/record.url?eid=2-s2.0-85159273259&partnerID=MN8TOARS.
    10.1038/s41593-023-01325-4
  5. André Miguel Miranda; Archana Ashok; Robin Barry Chan; Bowen Zhou; Yimeng Xu; Laura Beth McIntire; Estela Area-Gomez; et al. "Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice". Translational Psychiatry 12 1 (2022): https://doi.org/10.1038/s41398-022-01881-6.
    10.1038/s41398-022-01881-6
  6. Miguel Quintas-Neves; Merilee A. Teylan; Rafaela Morais-Ribeiro; Francisco Almeida; Charles N. Mock; Walter A. Kukull; John F. Crary; Tiago Gil Oliveira. "Divergent magnetic resonance imaging atrophy patterns in Alzheimer's disease and primary age-related tauopathy". Neurobiology of Aging (2022): https://doi.org/10.1016/j.neurobiolaging.2022.04.013.
    10.1016/j.neurobiolaging.2022.04.013
  7. Miguel Sá Breda; Ana Sousa Menezes; Tiago Gil Oliveira; Luís Dias. "Influence of Metabolic Syndrome on the Recovery from Idiopathic Sudden Sensorineural Hearing Loss". International Archives of Otorhinolaryngology (2022): https://doi.org/10.1055/s-0041-1741027.
    10.1055/s-0041-1741027
  8. Pinho, J.; Araújo, J.M.; Costa, A.S.; Silva, F.; Francisco, A.; Quintas-Neves, M.; Soares-Fernandes, J.; Ferreira, C.; Oliveira, T.G.. "Intracerebral Hemorrhage Recurrence in Patients with and without Cerebral Amyloid Angiopathy". Cerebrovascular Diseases Extra (2021): 15-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100287111&partnerID=MN8TOARS.
    10.1159/000513503
  9. Kalinichenko, L.S.; Mühle, C.; Jia, T.; Anderheiden, F.; Datz, M.; Eberle, A.-L.; Eulenburg, V.; et al. "Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects". Molecular Psychiatry 26 12 (2021): 7403-7416. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115835215&partnerID=MN8TOARS.
    10.1038/s41380-021-01304-w
  10. Oliveira, Tiago Gil; Ifrah, Chloe; Fleysher, Roman; Stockman, Michael; Lipton, Michael L.. "Soccer heading and concussion are not associated with reduced brain volume or cortical thickness". PLOS ONE 15 8 (2020): e0235609. http://dx.doi.org/10.1371/journal.pone.0235609.
    10.1371/journal.pone.0235609
  11. van Kruining, Daan; Luo, Qian; van Echten-Deckert, Gerhild; Mielke, Michelle M.; Bowman, Andrew; Ellis, Shane; Oliveira, Tiago Gil; Martinez-Martinez, Pilar. "Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods". Advanced Drug Delivery Reviews (2020): http://dx.doi.org/10.1016/j.addr.2020.04.009.
    10.1016/j.addr.2020.04.009
  12. Gago, M.F.; Azevedo, O.; Guimarães, A.; Teresa Vide, A.; Lamas, N.J.; Oliveira, T.G.; Gaspar, P.; et al. "Parkinson's Disease and Fabry Disease: Clinical, Biochemical and Neuroimaging Analysis of Three Pedigrees". Journal of Parkinson's Disease 10 1 (2020): 141-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-85078502643&partnerID=MN8TOARS.
    10.3233/JPD-191704
  13. André Miguel Miranda; Francisca Vaz Bravo; Robin B. Chan; Nuno Sousa; Gilbert Di Paolo; Tiago Gil Oliveira. "Differential lipid composition and regulation along the hippocampal longitudinal axis". Translational Psychiatry 9 1 (2019): https://doi.org/10.1038/s41398-019-0478-6.
    10.1038/s41398-019-0478-6
  14. Miguel Quintas-Neves; Merilee A. Teylan; Lilah Besser; João Soares-Fernandes; Charles N. Mock; Walter A. Kukull; John F. Crary; Tiago Gil Oliveira. "Magnetic resonance imaging brain atrophy assessment in primary age-related tauopathy (PART)". Acta Neuropathologica Communications (2019): https://doi.org/10.1186/s40478-019-0842-z.
    10.1186/s40478-019-0842-z
  15. Tabbai, S.; Moreno-Fernández, R.D.; Zambrana-Infantes, E.; Nieto-Quero, A.; Chun, J.; García-Fernández, M.; Estivill-Torrús, G.; et al. "Effects of the LPA1 receptor deficiency and stress on the hippocampal LPA species in mice". Frontiers in Molecular Neuroscience 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85069514845&partnerID=MN8TOARS.
    10.3389/fnmol.2019.00146
  16. Francisca Vaz Bravo; Jorge Da Silva; Robin Barry Chan; Gilbert Di Paolo; Andreia Teixeira-Castro; Tiago Gil Oliveira. "Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-21918-5.
    10.1038/s41598-018-21918-5
  17. Miranda, A.M.; Lasiecka, Z.M.; Xu, Y.; Neufeld, J.; Shahriar, S.; Simoes, S.; Chan, R.B.; et al. "Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures". Nature Communications 9 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85040774881&partnerID=MN8TOARS.
    10.1038/s41467-017-02533-w
  18. Tiago Gil Oliveira; João Paulo Soares-Fernandes. "Brain MRI in a patient with classical galactosemia: acute event of unilateral hemispheric cerebral edema". Child's Nervous System 33 11 (2017): 1879-1880. https://doi.org/10.1007/s00381-017-3594-8.
    10.1007/s00381-017-3594-8
  19. Oliveira, T.G.; Chan, R.B.; Bravo, F.V.; Miranda, A.; Silva, R.R.; Zhou, B.; Marques, F.; et al. "The impact of chronic stress on the rat brain lipidome". Molecular Psychiatry 21 1 (2016): 80-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951906991&partnerID=MN8TOARS.
    10.1038/mp.2015.14
  20. Lamas, Nuno Jorge; Amorim, João Filipe Pinheiro; Almeida, António Manuel Melo Soares; Mendes, Sofia Silva; Martins, Sandra; Teixeira, Pedro Alexandre Leão Araújo Gonçalves; Oliveira, Tiago Gil; et al. "Ensino da Anatomia na Escola de Ciências da Saúde da Universidade do Minho". (2016): http://hdl.handle.net/1822/50986.
  21. Miranda, A.M.; Oliveira, T.G.. "Lipids under stress - A lipidomic approach for the study of mood disorders". BioEssays 37 11 (2015): 1226-1235. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944597098&partnerID=MN8TOARS.
    10.1002/bies.201500070
  22. Pinto, V.; Costa, J.C.; Morgado, P.; Mota, C.; Miranda, A.; Bravo, F.V.; Oliveira, T.G.; Cerqueira, J.J.; Sousa, N.. "Differential impact of chronic stress along the hippocampal dorsal–ventral axis". Brain Structure and Function 220 2 (2015): 1205-1212. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944558041&partnerID=MN8TOARS.
    10.1007/s00429-014-0713-0
  23. Pinho, J.; Machado, C.; Oliveira, T.G.; Soares, I.; Magalhães, Z.; Maré, R.. "Dynamic myelopathy in Hirayama disease". Spine Journal 14 11 (2014): 2789-2790. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908547653&partnerID=MN8TOARS.
    10.1016/j.spinee.2014.06.026
  24. Mesquita, S.D.; Ferreira, A.C.; Falcao, A.M.; Sousa, J.C.; Oliveira, T.G.; Correia-Neves, M.; Sousa, N.; Marques, F.; Palha, J.A.. "Lipocalin 2 modulates the cellular response to amyloid beta". Cell Death and Differentiation 21 10 (2014): 1588-1599. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900894981&partnerID=MN8TOARS.
    10.1038/cdd.2014.68
  25. Chan, R.B.; Oliveira, T.G.; Cortes, E.P.; Honig, L.S.; Duff, K.E.; Small, S.A.; Wenk, M.R.; Shui, G.; Di Paolo, G.. "Comparative lipidomic analysis of mouse and human brain with Alzheimer disease". Journal of Biological Chemistry 287 4 (2012): 2678-2688. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856072382&partnerID=MN8TOARS.
    10.1074/jbc.M111.274142
  26. Roque, S.; Oliveira, T.G.; Nobrega, C.; Barreira-Silva, P.; Nunes-Alves, C.; Sousa, N.; Palha, J.A.; Correia-Neves, M.. "Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration". Frontiers in Behavioral Neuroscience FEBRUARY (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855237730&partnerID=MN8TOARS.
    10.3389/fnbeh.2011.00004
  27. Oliveira, T.G.; Chan, R.B.; Tian, H.; Laredo, M.; Shui, G.; Staniszewski, A.; Zhang, H.; et al. "Phospholipase D2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits". Journal of Neuroscience 30 49 (2010): 16419-16428. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650064098&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3317-10.2010
  28. Oliveira, T.G.; Di Paolo, G.. "Phospholipase D in brain function and Alzheimer's disease". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1801 8 (2010): 799-805. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953243856&partnerID=MN8TOARS.
    10.1016/j.bbalip.2010.04.004
  29. Longatto Filho, A.; Oliveira, T.G.; Pinheiro, C.; de Carvalho, M.B.; Curioni, O.A.; da Cunha Mercante, A.M.; Schmitt, F.C.; Gattás, G.J.F.. "How useful is the assessment of lymphatic vascular density in oral carcinoma prognosis?". World Journal of Surgical Oncology 5 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-39049171778&partnerID=MN8TOARS.
    10.1186/1477-7819-5-140
Livro
  1. Silva, F.S.; Oliveira, T.G.; Alves, V.. Study of MRI-Based Biomarkers on Patients with Cerebral Amyloid Angiopathy Using Artificial Intelligence. 2021.
    10.1007/978-3-030-72657-7_18
Poster em conferência
  1. Francisca Vaz Bravo; DA SILVA, JORGE D.; Chan, Robin Barry; Di Paolo, Gilbert; Teixeira-Castro, Andreia; Oliveira, Tiago Gil. "The impact of PLD functional ablation in an Alzheimer's disease Caenorhabditis elegans model". Trabalho apresentado em 47th Society for Neuroscience, 2017.
  2. Francisca Vaz Bravo; DA SILVA, JORGE D.; Chan, Robin Barry; Di Paolo, Gilbert; Teixeira-Castro, Andreia; Oliveira, Tiago Gil. "The impact of phospholipase D functional ablation in physiology and in disease models in Caenorhabditis elegans". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, 2017.
Resumo em conferência
  1. P. Ribeiro, Inês; Rosana Aves; Morais-Ribeiro, Rafaela; Paiva, Sandra; Oliveira, Tiago Gil. Autor correspondente: Oliveira, Tiago Gil. "Expression of Mammalian PLD1 and PLD2 in the Yeast Model". 2022.
    10.21814/1822.75916
Tese / Dissertação
  1. Oliveira, Tiago Gil. "The role of phospholipase D2 in Alzheimer's disease". Doutoramento, 2010. http://hdl.handle.net/1822/12235.

Outros

Outra produção
  1. SorCS2 deletion leads to altered neuronal lysosome activity. 2021. Almeida, S.; Miranda, A.M.; Tóth, A.E.; Nielsen, M.S.; Oliveira, T.G.; Glerup, S.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106370303&partnerID=MN8TOARS.
    10.1101/2021.04.08.439000
  2. Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning. Cell Reports. 2019. Marinha, L.S.; Castanho, I.; Silva, R.R.; Bravo, F.V.; Miranda, A.M.; Xu, Y.; Point du Jour, K.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85112498654&partnerID=MN8TOARS.
    10.2139/ssrn.3462748
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/11 The role of lipid signaling in Alzheimer’s disease NeuroDay
I3S Research Institute (Porto, Portugal)
2023/10 The role of lipid signaling in Alzheimer’s disease 1st Nova Medical School Research Week
Nova Medical School (Lisboa, Portugal)
2023/10 Anti-amyloid antibody treatment for Alzheimer’s disease 46th European Society of Neuroradiology Annual Meeting
ESNR (Vienna, Áustria)
2023/09 The role of the phospholipase D pathway in hippocampal functioning and Alzheimer’s disease 2nd Symposium on lipids in brain diseases
(Leiden, Países Baixos)
2023/09 Lipidomic insights into Alzheimer’s disease pathogenesis Lipidomic insights into Alzheimer’s disease pathogenesis
FEBBS (Funchal, Portugal)
2023/06 Brain magnetic resonance imaging changes in Frontotemporal Dementia 37th Portuguese Meeting on Brain Aging and Dementia
GEECD (Lisboa, Portugal)
2023/04 Lewy body co-pathology contributes to frontal lobe atrophy in Alzheimer’s disease and primary age-related tauopathy 4th Eurotau Meeting
(Lille, França)
2022/12 The role of the phospholipase D pathway in hippocampal functioning and Alzheimer’s disease Invited seminar
Columbia University, Taub Institute (New York, Estados Unidos)
2022/11 Unravelling Alzheimer’s disease pathogenesis through brain MRI & neuropathology approaches Invited Seminar
Champalimaud Foundation (Lisboa, Portugal)
2022/09 The role of the phospholipase D pathway in hippocampal functioning and Alzheimer’s disease 10th Westerberger Herbsttagung - Membranes and the Cytoskeleton in Health and Neurodegenerative Disease
Osnabrück University (Osnabrück, Alemanha)
2022/04 The role of the phospholipase D pathway in the nervous system functioning and Alzheimer's disease Invited Seminar
University of Geneva (Geneva, Suiça)
2022/02/03 Brain regional susceptibility to neurodegenerative disorders - from lipidomic signatures to MRI approaches (online) Invited seminar
Cornell University, NY, USA. Host: Mony de Leon (New York, Estados Unidos)
2021/10/25 Primary age-related tauopathy (PART) and Alzheimer’s disease show differential magnetic resonance imaging atrophy patterns 3rd Eurotau Meeting
Eurotau (Lille, França)
2021/10/15 The impact of chronic stress on the brain lipidome – implications for mood disorders and Alzheimer’s disease XXI Portuguese Society for Biochemistry, National Congress of Biochemistry
Portuguese Society for Biochemistry (Évora, Portugal)
2021/07/06 Differential impact of hippocampal longitudinal axis modulation in chronic stress and Alzheimer’s disease Invited seminar
NeuroSpin, Paris, France. Host: Sébastien Meriaux (Paris, França)
2021/02/14 Studying mood disorders and hippocampal functioning with lipidomic approaches Sphingolipid Biology Webinar Series
Sphingolipid Club - https://youtu.be/9IRpVXZ5co4 (Online Seminar, Estados Unidos)
2020/12/15 Brain Imaging in Alzheimer’s disease – from clinical practice to research International Workshop in Translational Neurology - Blood-Brain Barrier in the Clinical setting
CNC, Coimbra, Portugal [Online Seminar] (Coimbra, Portugal)
2020/12/14 My path from Neuroscience to Neuroradiology 2020 Faculty of Medicine, University of Lisbon, Day of Research
GAPIC, Office for Support for Scientific Research, Lisbon, Portugal (Lisboa, Portugal)
2020/12/14 14 years of the Minho MD/PhD Program III Research Symposium of the Portuguese Medical Schools - Online
Faculty of Medicine, University of Lisbon, Lisbon, Portugal (Lisboa, Portugal)
2020/09/04 Phospholipase D1 ablation disrupts mouse longitudinal hippocampal axis organization and functioning American Society for Biochemistry and Molecular Biology – Lipid Research Division Seminar Series”. September - https://www.asbmb.org/meetings-events/phospholipases-and-disease [Online Seminar]
American Society for Biochemistry and Molecular Biology – Lipid Research Division (Online Seminar, Estados Unidos)
2020/09/01 Brain imaging in Alzheimer’s disease – emerging new concepts from imaging-pathology studies 34th Portuguese Dementia and Brain Aging Study Group Meeting. [Online Seminar]
Portuguese Dementia and Brain Aging Study Group (Coimbra, Portugal)
2020/07/15 Lipid metabolism in hippocampal functioning 2nd Membrane Trafficking Workshop
International Iberian Nanotechnology Institute, Braga, Portugal. [Online Seminar] (Braga, Portugal)
2020/01 Alzheimer's disease, dementia and neurodegeneration - from patients to basic research Neuroscience and Mental Health course
University of Coimbra (Coimbra, Portugal)
2019/10 Phospholipase D1 ablation disrupts dorsal-ventral hippocampal axis 2019 Society for Neuroscience Meeting
Society for Neuroscience (Chicago, Estados Unidos)
2019/10 The role of the phospholipase D pathway in the nervous system functioning and Alzheimer's disease Invited Seminar
Kyunghee Koh - Thomas Jefferson University (Philadelphia, Portugal)
2019/06 Differential lipid composition and regulation along the hippocampal longitudinal axis 1st Membrane Trafficking Workshop
International Iberian Nanotechnology Institute (Braga, Portugal)
2019/06 The role of phospholipase D pathway in neurodegeneration XVI Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Lisboa, Portugal)
2019/03 Building an MD/PhD program as a scientific hub to promote biomedical research Orpheus Conference – 2019
Orpheus - University College Dublin (Dublin, Irlanda)
2018/11 Quantitative neuroimaging metrics to study neurodegenerative diseases 2018 Portuguese Neurology Society Conference
Portuguese Neurology Society (Porto, Portugal)
2018/07 The role of phospholipase D in nervous system physiology and pathology Invited seminar
Mount Sinai Hospital - Edoardo M. Marcora (New York, Estados Unidos)
2018/07 Lipids under stress 2nd Small Meeting on Endocytic Trafficking and Signaling
International Iberian Nanotechnology Institute (Braga, Portugal)
2017/09 Lipids under stress – a lipidomic approach for the study of mood disorders XII Sphingolipid Club Meeting
Sphingolipid Club (Trabia, Itália)
2017/06 Macrostructural impact of Soccer in brain morphometry: MRI volumetric and cortical thickness analysis XIII Portuguese Neuroradiology Meeting
Portuguese Neuroradiology Society (Estarreja, Portugal)
2017/06 The impact of chronic stress on the rat brain lipidome”. Invited seminar 2017 – ICVS open day
ICVS - University of Minho (Braga, Portugal)
2016/10 Lipids under stress – a lipidomic approach for the study of mood disorders Invited seminar
New York University - Robert C. Froemke (New York, Estados Unidos)
2016/06 Lipids under stress – a lipidomic approach for the study of mood disorders Invited seminar
Ana Cristina Rego - University of Coimbra (Coimbra, Portugal)
2016/06 Lipids under stress – a lipidomic approach for the study of mood disorders Invited seminar
Friedrich-Alexander-University Erlangen-Nuremberg - Christian P. Müller (Erlangen, Alemanha)
2015/01 The role of antiphospholipid antibodies in the antiphospholipid syndrome 2015 Portuguese Stroke Conference
Portuguese Stroke Society (Porto, Portugal)
2014/09 Lipid signaling in brain physiology and pathology Thomas Jefferson / Minho Universities Joint Meeting - Invited seminar
ICVS - University of Minho (Braga, Portugal)
2013/10 Lipid signaling in Alzheimer’s disease”. Invited seminar – “”, IBRO Meeting – Current aspects in the pathophysiology of Alzheimer’s disease
IBRO (Braga, Portugal)
2013/05 Characterization of a phospholipase D mutant C. elegans model 2013 European MD/PhD Conference
European MD/PhD Association (Paris, França)
2010/11 The role of Phospholipase D2 in Alzheimer’s disease”. Selected from abstract submission 2010 Society for Neuroscience Meeting
Society for Neuroscience (San Diego, Estados Unidos)
2006/12 Tumour Lymphangiogenesis in Head and Neck Squamous Cell Carcinoma XLI Congress of the Portuguese Society for Microscopy
Portuguese Society for Microscopy (Braga, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017 - Atual Lipid signaling determinants of hippocampal excitability
Orientador
 Medicine (Doutoramento)
2016 - Atual Anti-inflammatory effect of carbon monoxide on the neuron-microglia bidirectional communication
Coorientador
 Ageing and Chronic Diseases (Doutoramento)
2015 - 2019 Dissecting the mechanisms of dynein recruitment to the nuclear envelope during neocortical development
Coorientador
 Medicina (Doutoramento)
Universidade do Minho, Portugal
2014 - 2019 Investigating the role of Taranis and Wingless/Wnt signaling in sleeping regulation
Coorientador
 Medicina (Doutoramento)
Universidade do Minho, Portugal
2014 - 2018 Endolysosomal dysfunction and exosome secretion: implications for neurodegenerative disorders
Orientador
 Medicina (Doutoramento)
Universidade do Minho, Portugal
2013 - 2018 The role of signaling lipids in the nervous system physiology and pathology: mechanistic insights of the phospholipase D pathway in neurodegenerative diseases
Orientador
 Envelhecimento e Doenças Crónicas (associação) (Doutoramento)
Universidade do Minho, Portugal
2014 - 2015 The impact of phospholipase D ablation in the mouse hippocampus
Orientador
 Ciências da Saúde (Mestrado)
Universidade do Minho, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2014 - Atual ICVS International Seminar Series - Various (2014)
Seminário (Coorganizador)
 Universidade do Minho, Portugal
2018 - 2018 2nd MD/PhD retreat - As PhD in Medicine course director I organised the program retreat, which also had the participation of external committee member, Prof. Alcino Silva (UCLA, USA). (2018 - 2018)
Encontro (Presidente da Comissão Organizadora)
 Universidade do Minho, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023 Investigating the association of endocytic trafficking regulator CD2AP gene variant K633R and the risk of developing Alzheimer´s disease
Arguente principal
 Farzaneh Sadat Mirfakhar (Doutoramento)
Universidade Nova de Lisboa, Portugal
2023 Corticostriatal circuitry dysfunction in neuropsychiatric disorders
Arguente
 Diana Rodrigues (Doutoramento)
Universidade do Minho, Portugal
2023 Psychostimulants and neuroninflammation: finding critical players in the crosstalk between glial cells and neurons
Arguente principal
 Joana Catarina da Silva Bravo (Doutoramento)
Universidade do Porto, Portugal
2023 Self-modulation of executive system with real-time fMRI: a neurofeedback protocol design and implementation in autism
Arguente principal
 Daniela Jardim Pereira (Doutoramento)
Universidade de Coimbra, Portugal
2023 Developmental venous anomalies, cerebral cavernous malformations and beyound: neuroimaging insight into pediatric cerebrovenous vascular malformations
Arguente principal
 Ana Filipa Geraldo (Doutoramento)
Universidade do Porto, Portugal
2023 Dissecting the role of parvalbumin positive inhibitory neurons in the cellular and behavioral phenotypes associated with Gprasp2 deletion
Arguente principal
 Mariana Barradas Serrano Laranjo (Doutoramento)
Universidade de Coimbra, Portugal
2023 The role of functional connectivity in the treatment of depression: exploring novel neuroimaging techniques
Vogal
 Joana Reis (Doutoramento)
Universidade do Minho, Portugal
2022/02/24 An integrative approach to the study of diet on cognitive function in ageing and effects of age on behavioural change: associations between Mediterranean diet and MRI-based measures and the effect of age on a brief motivational intervention
Arguente
 Belina Rodrigues (Doutoramento)
Universidade do Minho, Portugal
2022 The Role of Serotonin in Regulation of Benign Prostatic Growth – Implications for Benign Prostatic Hyperplasia Etiology
Arguente
 Emanuel Carvalho Dias (Doutoramento)
2022 Apolipoprotein E lipidation in Alzheimer’s disease
Arguente principal
 Karina Linder (Doutoramento)
Université de Genève, Suiça
2022 MRI biomarkers of the stressed brain: disclosing interactions between perception, morphology and functioning
Arguente
 Inês Caetano (Doutoramento)
Universidade do Minho, Portugal
2022 Serotonergic signaling modulation as a thepareutic strategy for Machado-Joseph disease: finding the molecular traits
Arguente
 Stéphanie Oliveira (Doutoramento)
Universidade do Minho, Portugal
2022 Studying the neuroprotective role of bone marrow-derived mesenchymal stem cell secretome using in vitro and in vivo models of Parkinson’s disease
Arguente
 Bárbara Pinheiro (Doutoramento)
Universidade do Minho, Portugal
2021/12/16 The impact of the genetic risk factor BIN1 on Alzheimer’s disease development
Arguente principal
 Catarina Perdigão (Doutoramento)
Universidade Nova de Lisboa, Portugal
2021/11/24 The human brain connectome in aging: MRI biomarkers of cognitive preservation and decline
Arguente
 Ana Coelho (Doutoramento)
Universidade do Minho, Portugal
2021/11/15 Carbon monoxide modulation of glial cells on cytoprotection
Arguente principal
 Daniela Dias-Pedroso (Doutoramento)
Universidade Nova de Lisboa Comprehensive Health Research Centre, Portugal
2021/09/07 Chronic stress and glucocorticoid actions in brain plasticity and Tau pathology
Arguente
 Chrysoula Dioli (Doutoramento)
Universidade do Minho, Portugal
2021/07/07 Development of vascularizable hydrogels to promote spinal cord injury repair: from RGD to mimetic ligands
Arguente
 Luís António Rocha (Doutoramento)
Universidade do Minho, Portugal
2021/05/12 Insights from Caenorhabditis elegans models into neurogenetic disorders of the motor system: from fundamental to translational research
Arguente
 Jorge Diogo Da Silva (Doutoramento)
Universidade do Minho, Portugal
2021/05/04 Validation of a Novel Intervention Based on Digital Biofeedback for Home-based Rehabilitation after Hip or Knee Replacement
Arguente
 Fernando Correia (Doutoramento)
Universidade do Minho, Portugal
2021/02/04 Cognitive and emotional regulation in stress and obsessive-compulsive disorder
Arguente
 Sónia Ferreira (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2020/11/01 Exploring the crosstalk between mood and metabolism: new insights from ageing, obesity and depression
Arguente
 Carlos Portugal Nunes (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2020/09/04 The Role of TorsinA in Brain Lipid Metabolism
Arguente principal
 Ana Cascalho (Doutoramento)
Katholieke Universiteit Leuven Departement Cellulaire en Moleculaire Geneeskunde, Bélgica

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018 - Atual Co-Responsible for the organization of the curricular area “Final Optional Project” – equivalent to the Master in Medicine thesis during the sixth year of Medical School Final Optional Project Universidade do Minho, Portugal
2018 - Atual Lecturer in “Clinical Neurosciences” – responsible for classes on clinical neuroimaging during the fourth year of Medical School Clinical Neurosciences (Mestrado integrado) Universidade do Minho, Portugal
2018 - Atual Lecturer in “Biopathology” - responsible for classes on various aspects of disease mechanisms during the third year of Medical School Biopathology (Mestrado integrado) Universidade do Minho, Portugal
2018 - Atual Lecturer in “Molecules and Cells” – responsible for classes on lipid signaling and metabolism during the first year of Medical School Molecules and Cells (Mestrado integrado) Universidade do Minho, Portugal
2017 - Atual Fundamentals in Neuroscience - Coordinator Fundamentals in Neuroscience (Doutoramento) Universidade do Minho, Portugal
2015 - Atual Responsible for the organization of the “Central Nervous System” course, as part of the second year Medical School curricular unit “Functional and Organic Systems III” Functional and Organic Systems III (Mestrado integrado) Universidade do Minho, Portugal
2011 - Atual Lecturer in Gross Anatomy, Neuroanatomy and Clinical Anatomy, as part of the academic training of the first and second year Medical School in “Functional and Organic Systems I, II and III”; and first year Medical School (4 year track) in “Fundamentals in Medicine” Functional and Organic Systems I, II and III (Mestrado integrado) Universidade do Minho, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2021/02/15 - 2021/02/15 RUM - Information Broadcast Artificial Intelligence - Alzheimer's disease diagnosis

Membro de associação

Nome da associação Tipo de participação
2023/05 - Atual Portuguese Society for Neuroscience President
2017 - Atual Sphingolipid Club Board Member
2019 - 2023 Portuguese Society for Neuroscience Vice-President
2015 - 2019 Portuguese Society for Neuroscience Secretary
2009 - 2010 Faculty 1000 biology Faculty Member
Distinções

Prémio

2022 Prémio Pfizer
Sociedade das Ciências Médicas de Lisboa, Portugal

Outra distinção

2017 2017 Research Award (for the highest impact original research work in 2016)
2014 Scholarship in Clinical Research