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Invited Assistant Professor, School of Medicine, University of Minho, Braga, Portugal. Graduation in biology, University of Porto, Portugal; PhD in neuro-oncology, IARC, France; Post-doc in cancer genomics, IPATIMUP / Portugal and VUMC / The Netherlands. Researcher productivity CNPq 1B. Scientific Director of the Research and Teaching Institute (IEP) and Coordinator of the Molecular Oncology Research Center (CPOM) of Barretos Cancer Hospital, Barretos, SP. Brazil.Extraordinary Professor, at Pan African Cancer Research Institute, University of Pretoria, South Africa.
Identificação

Identificação pessoal

Nome completo
RUI MANUEL VIEIRA REIS

Nomes de citação

  • Reis, RM
  • Reis, Rui Manuel

Identificadores de autor

Ciência ID
FB1F-DC2C-25D4
ORCID iD
0000-0002-9639-7940
Google Scholar ID
PLkVSekAAAAJ
Researcher Id
B-1744-2018
Scopus Author Id
8203632800

Moradas

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2002 - 2003
Concluído
Health Sciences (Pós-doutoramento)
Especialização em Human and Medical Genetics
VU Medisch Centrum, Países Baixos

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1998 - 2002
Concluído
Biologia Humana (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

International Agency for Research on Cancer, França
"Genetic alterations associated with development of human diffusely infiltrating astrocytomas" (TESE/DISSERTAÇÃO)
1991 - 1995
Concluído
Biologia (Licenciatura)
Universidade do Porto, Portugal
"Involvement of Mycoplasma-like Organisms (MLO) as a causal agent for the Yellwos disease in Rubus plants" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2011 - Atual Investigador Coordenador (carreira) (Investigação) Hospital de Amor, Brasil
Centro de Pesquisa em Oncologia Molecular, Brasil
2010/05 - Atual Investigador principal (carreira) (Investigação) Hospital de Amor, Brasil
Centro de Pesquisa em Oncologia Molecular, Brasil
2003 - Atual Investigador principal (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2002 - 2003 Pós-doutorado (Investigação) VU Medisch Centrum, Países Baixos
2001 - 2003 Investigador (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2020 - Atual Professor Associado (Docente Universitário) Universidade do Minho, Portugal
2010 - 2019 Professor Auxiliar Convidado (Docente Universitário) Universidade do Minho, Portugal
2003 - 2010 Professor Auxiliar (Docente Universitário) Universidade do Minho, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2021/09 - Atual Extraordinary Professor University of Pretoria, África do Sul
Pan African Cancer Research Institute, África do Sul
2019 - 2021/12/13 Pró-Reitor Hospital de Amor, Brasil

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2015 - Atual Scientific Director- IEP Hospital de Amor, Brasil
2018 - 2021/12/01 Executive Director- IEP Hospital de Amor, Brasil
2015 - 2019 Coordinator of PIBIC Hospital de Amor, Brasil
1998 - 2001 PhD Student International Agency for Research on Cancer, França
1996 - 1997 Young Reasearch Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - Atual Embryonic T-box transcription factor Brachyury: Dissecting its role in prostate cancer biology and clinical application
PTDC/MED-ONC/31423/2017
Investigador responsável
Universidade do Minho Escola de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2016 - Atual O conceito de moléculas-combinadas: uma nova abordagem no tratamento de câncer de pulmão avançado
Cancer research UK grants
Investigador
Cancer Research UK
Em curso
2014 - Atual Avaliação do câncer ocupacional e do potencial risco em trabalhadores rurais expostos a agentes carcinogênicos ambientais e ocupacionais na região de Barretos
Chamamento Publico n°20 – Estudos e Pesquisas Aplicadas em Vigilância em Saúde
Investigador
Ministério da Saúde
Em curso
2013 - Atual Estudo do papel biológico e terapêutico da Raf kinase inhibitor protein (RKIP) em GISTs e sua correlação com o fenótipo de instabilidade de microssatélites (MSI)
14/2013
Investigador responsável
Fundação de Amparo à Pesquisa do Estado de São Paulo
Em curso
2013 - Atual Estudo funcional da modulação dos miRNAs, miR-451 e miR-720, em linhagens celulares de tumores humanos
12/23326-6
Investigador
Centro de Pesquisa em Oncologia Molecular, Brasil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Em curso
2010/01/01 - Atual Cell-intrinsic and microenvironmental signals intertwined: novel targets for therapeutic intervention in acute lymphoblastic leukemia?
Investigador
Instituto de Medicina Molecular, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia
2010 - Atual Role of WNK2 as a tumours suppressor gene in malignant gliomas
PTDC/SAU-OBD/100079/2008
Investigador
Em curso
2006 - Atual Molecular Profile of Portuguese GISTs
NOVASTIS2006
Investigador
Novartis Farma SA
Em curso
2023/05/01 - 2025/05/01 PAPEL DA CD24, UMA PROTEÍNA DO “CHECKPOINT” IMUNOLÓGICO, NA BIOLOGIA E TERAPIA DE MEDULOBLASTOMAS
FROC_ICVS_2023
Principal Investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
2016 - 2019 PersonalizedNOS: New avenues for the development of personalized medical interventions for neurological, oncologic and surgical disorders
NORTE-01-0145-FEDER-000013
Investigador
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluído
2014 - 2016 BIOPLAT – Plataforma Brasileira para Estudos de Bioprospecção de compostos naturias com potencial anticâncer em fase pré-clínica
MCTI/FINEP/MS/SCTIE/DECIT-1302/13
Investigador responsável
Finep
Concluído
2013 - 2015 Creation of large animal models to test the concepts of no scar, no radiation exposure approaches for minimally invasive surgery in the oncological field
NORTE-07-0124-FEDER-000017
Investigador
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluído
2013 - 2015 Estudo do efeito antineoplásico de extratos e derivados de Euphorbia tirucalli em tumores cerebrais e células tronco tumorais cerebrais
MCTI/CNPq Nº 73/2013
Investigador responsável
Conselho Nacional de Desenvolvimento Científico e Tecnológico
2012 - 2015 Estudo pré-clinico dos potenciais compostos anti-neoplásicos AM10 e AM11
Amazônia Fitomedicamentos
Investigador responsável
Centro de Pesquisa em Oncologia Molecular, Brasil
Amazônia Fitomedicamentos
2011/04/01 - 2014 The Transcriptome of the Oncogenic HOXA9 Homeoprotein in Human Glioblastoma: Characterization and Functional Significance
Investigador
Universidade do Minho Escola de Medicina, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
2011/02/01 - 2014 Identification of novel target genes in microsatellite unstable brain tumours
Investigador responsável
Universidade do Minho Escola de Medicina, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
2011 - 2014 Potential predictive biomarkers of anti-RTKs therapy response in gliomas: An “in vitro” and “in vivo” Study
PTDC/SAU-TOX/114549/2009
Investigador responsável
Universidade do Minho Escola de Medicina, Portugal
Concluído
2012 - 2013 Caracterização da instabilidade genômica em glioblastomas: identificação e elucidação de novas vias moleculares em tumores e culturas primárias
CNPq Nº 014/2011
Investigador responsável
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluído
2011 - 2013 Avaliação do papel de microRNAs diferencialmente expressos no controle de invasão e metástase do câncer de mama
10/16796-0
Investigador
Hospital do Câncer de Barretos. Fundação Pio XII (FP), Brasil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluído
2010 - 2012 Implantação do Centro de Pesquisa Translacional em Oncologia
CT-INFRA-02/2010
Investigador responsável
Centro de Pesquisa em Oncologia Molecular, Brasil
Finep
Concluído
2007 - 2009 Study of Therapeutic Target c-KIT in Brain Tumours
Prof. Francisco Gentil 2006
Investigador
Pfizer Biofarmacêutica Sociedade Unipessoal Lda
Concluído
2004 - 2009 Study of Molecular Predictive Factors of Chemotherapy Response in High-Grade Gliomas
Novartis2004
Investigador
Novartis Farma SA
Concluído
2003 - 2009 Analysis of Receptor Tyrosine Kinases in Uterine Cervix Cancer
Scheringh-Plough Grants
Investigador
Scheringh-Plough
Concluído
2002/12/01 - 2004 Application of microarray CGH for the study of chromosomal instability at different stages of gastric carcinogenesis
Bolseiro de Pós-Doutoramento
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído

Projeto

Designação Financiadores
2011/04/01 - 2014/09/30 O Transcriptoma da Homeoproteína Oncogénica HOXA9 em Glioblastomas Humanos: Caracterização e Consequências Funcionais
PTDC/SAU-GMG/113795/2009
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 26 - 2011-2012
PEst-C/SAU/LA0026/2011
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2012/02/29 Papel da proteína cinase WNK2 como gene supressor de gliomas malignos
PTDC/SAU-OBD/100079/2008
Universidade do Minho, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Moniz, Sonia; Martinho, Olga; Pinto, Filipe; Reis, Rui Manuel; Jordan, Peter. "Protein Kinase WNK2 has a Tumour Suppressor Role in Gliomas". 2012.
Artigo em revista
  1. Laura Torrens; Sarah Moody; Ana Carolina de Carvalho; Mariya Kazachkova; Behnoush Abedi-Ardekani; Saamin Cheema; Sergey Senkin; et al. "The complexity of tobacco smoke-induced mutagenesis in head and neck cancer". Nature Genetics (2025): http://dx.doi.org/10.1038/s41588-025-02134-0.
    10.1038/s41588-025-02134-0
  2. Vicente ALSA; de Souza Santos FA; Hirai WY; Lissa D; de Oliveira Cavagna R; da Silva ALV; Dos Reis MB; et al. "HOXA9 methylation is not associated with survival in Brazilian patients with lung adenocarcinoma.". Clinical epigenetics (2025): http://europepmc.org/abstract/med/39962529.
    10.1186/s13148-025-01831-1
  3. Natália Noronha Ferreira; Celisnolia Morais Leite; Natália Sanchez Moreno; Renata Rank Miranda; Paula Maria Pincela Lins; Camila Fernanda Rodero; Edilson de Oliveira Junior; et al. "Nose-to-Brain Delivery of Biomimetic Nanoparticles for Glioblastoma Targeted Therapy". ACS Applied Materials & Interfaces (2025): https://doi.org/10.1021/acsami.4c16837.
    10.1021/acsami.4c16837
  4. Megid RA; Ribeiro GG; Gomes INF; Laus AC; Ferro Leal L; Sussuchi da Silva L; Ariwoola AA; et al. "Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling.". Frontiers in molecular biosciences (2025): http://europepmc.org/abstract/med/39950162.
    10.3389/fmolb.2025.1537523
  5. Flávia Escremim de Paula; Murilo Bonatelli; Monise Tadin dos Reis; Karla Emília de Sá Rodrigues; Léon C. van Kempen; Gustavo Ramos Teixeira; Rui Manuel Reis. "Enhancing precision in sarcoma diagnosis: nCounter fusion panel implementation in a middle-income country". Therapeutic Advances in Medical Oncology (2025): https://doi.org/10.1177/17588359251318159.
    10.1177/17588359251318159
  6. Andrade DAP; Bonatelli M; de Paula FE; Berardinelli GN; Teixeira GR; Dos Reis MT; Barbin FF; et al. "Implementation of the ProMisE classifier and validation of its prognostic impact in Brazilian endometrial carcinomas.". Frontiers in oncology (2024): https://europepmc.org/articles/PMC11671357.
    10.3389/fonc.2024.1503901
  7. Resende PVS; Gomes INF; Peixoto MC; Stringhetta GR; Arantes LMRB; Kuzmin VA; Borissevitch I; et al. "Evaluation of the antineoplastic properties of the photosensitizer biscyanine in 2D and 3D tumor cell models and artificial skin models.". Journal of photochemistry and photobiology. B, Biology (2024): https://doi.org/10.1016/j.jphotobiol.2024.113078.
    10.1016/j.jphotobiol.2024.113078
  8. Dos Reis MB; Dos Santos W; de Carvalho AC; Lima AB; Reis MT; Santos F; Reis RM; Guimarães DP. "Plasma mutation profile of precursor lesions and colorectal cancer using the Oncomine Colon cfDNA Assay.". BMC cancer (2024): http://europepmc.org/abstract/med/39695441.
    10.1186/s12885-024-13287-2
  9. Bárbara Borella Fernandes; Jose Guilherme Datorre; Fabiana de Lima Vazquez; Ana Carolina de Carvalho Peters; Fabio Luiz Coracin; Rui Manuel Reis; Lidia Maria Rebolho Batista Arantes; Ricardo Ribeiro Gama. "Association of Fusobacterium nucleatum Levels by ddPCR in Oral Rinse Samples With Periodontal Disease in Oral Squamous Cell Carcinoma Patients and in Controls". Journal of Oral Pathology & Medicine (2024): https://doi.org/10.1111/jop.13580.
    10.1111/jop.13580
  10. Marcela Vieira Lordelo; Lucy W. Kivuti-Bitok; Cleyton Zanardo Oliveira; Luisa Aguirre Buexm; Rui Manuel Vieira Reis; Adhemar Longatto-Filho; Júlio César Possati-Resende; Fabiana de Lima Vazquez; José Humberto Tavares Guerreiro Fregnani. "Randomized experimental population-based study to evaluate the acceptance and completion of and preferences for cervical cancer screening". PLOS ONE (2024): https://doi.org/10.1371/journal.pone.0306130.
    10.1371/journal.pone.0306130
  11. Diptavo Dutta; Xinyu Guo; Timothy D. Winter; Om Jahagirdar; Mark P. Purdue; Mitchell J. Machiela; Bryan R. Gorman; et al. "Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma". The American Journal of Human Genetics (2024): http://dx.doi.org/10.1016/j.ajhg.2024.07.012.
    10.1016/j.ajhg.2024.07.012
  12. Luis Eduardo Rosa Zucca; Ana Carolina Laus; Bruna Pereira Sorroche; Eduarda Paro; Luciane Sussuchi; Rui Ferreira Marques; Gustavo Ramos Teixeira; et al. "Immune-checkpoint gene expression and BCG response in non-muscle invasive bladder cancer". Translational Oncology (2024): https://doi.org/10.1016/j.tranon.2024.102003.
    10.1016/j.tranon.2024.102003
  13. Ana Laura Vieira Alves; Angela Margarida Costa; Olga Martinho; Vinicius Duval da Silva; Peter Jordan; Viviane Aline Oliveira Silva; Rui Manuel Reis. "Correction: Alves et al. WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line. Cells 2020, 9, 485". Cells (2024): https://doi.org/10.3390/cells13141219.
    10.3390/cells13141219
  14. José Guilherme Datorre; Mariana Bisarro Reis; Ana Carolina de Carvalho; Jun Porto; Gabriela Helena Rodrigues; Adhara Lima; Monise Reis; et al. "Enhancing Colorectal Cancer Screening with Droplet Digital PCR (ddPCR) Analysis of Fusobacterium nucleatum in Fecal Immunochemical Test (FIT) Samples". Cancer Prevention Research (2024): http://dx.doi.org/10.1158/1940-6207.capr-23-0331.
    10.1158/1940-6207.capr-23-0331
  15. Causin, RL; Mariana Polezi; Ana Julia Aguiar de Freitas; Calfa S; Wanessa Fernanda Altei; Julia Oliveira Dias; Ana Carolina Laus; et al. "EV-miRNAs from breast cancer patients of plasma as potential prognostic biomarkers of disease recurrence". Heliyon (2024): http://dx.doi.org/10.1016/j.heliyon.2024.e33933.
    10.1016/j.heliyon.2024.e33933
  16. Diana Cardoso-Carneiro; Joana Pinheiro; Patrícia Fontão; Rosete Nogueira; Maria Gabriela-Freitas; Ana Raquel-Cunha; Adriana Mendes; et al. "Unveiling the RKIP and EGFR Inverse Relationship in Solid Tumors: A Case Study in Cervical Cancer". Cancers (2024): https://www.mdpi.com/2072-6694/16/12/2182.
    10.3390/cancers16122182
  17. Barateiro LGRP; de Oliveira Cavagna R; Dos Reis MB; de Paula FE; Teixeira GR; Moreno DA; Bonatelli M; et al. "Somatic mutational profiling and clinical impact of driver genes in Latin-Iberian medulloblastomas: Towards precision medicine.". Neuropathology : official journal of the Japanese Society of Neuropathology (2024): http://europepmc.org/abstract/med/38736183.
    10.1111/neup.12979
  18. Senkin S; Moody S; Díaz-Gay M; Abedi-Ardekani B; Cattiaux T; Ferreiro-Iglesias A; Wang J; et al. "Geographic variation of mutagenic exposures in kidney cancer genomes.". Nature (2024): http://europepmc.org/abstract/med/38693263.
    10.1038/s41586-024-07368-2
  19. Santarosa Vieira AG; da Silva LS; Albino da Silva EC; Laus AC; Faria TMV; van Helvoort Lengert A; Martins GE; et al. "Comprehensive microRNA expression analysis of pediatric gonadal germ cell tumors: unveiling novel biomarkers and signatures.". Molecular oncology (2024): http://europepmc.org/abstract/med/38725152.
    10.1002/1878-0261.13617
  20. Lorena Vázquez-Iglesias; Giovanna Maria Stanfoca Casagrande; Daniel García-Lojo; Letícia Ferro Leal; Tien Anh Ngo; Jorge Pérez-Juste; Rui Manuel Reis; Krishna Kant; Isabel Pastoriza-Santos. "SERS sensing for cancer biomarker: Approaches and directions". Bioactive Materials (2024): https://doi.org/10.1016/j.bioactmat.2023.12.018.
    10.1016/j.bioactmat.2023.12.018
  21. Laus AC; Gomes INF; da Silva ALV; da Silva LS; Milan MB; AparecidaTeixeira S; Martin ACBM; et al. "Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line.". Human cell (2024): http://europepmc.org/abstract/med/38565739.
    10.1007/s13577-024-01054-1
  22. Purdue MP; Dutta D; Machiela MJ; Gorman BR; Winter T; Okuhara D; Cleland S; et al. "Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions.". Nature genetics (2024): http://europepmc.org/abstract/med/38671320.
    10.1038/s41588-024-01725-7
  23. Joana Pereira-Vieira; Daniela D. Weber; Sâmia Silva; Catarina Barbosa-Matos; Sara Granja; Rui Manuel Reis; Odília Queirós; et al. "Glucose Metabolism as a Potential Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16040442.
    10.3390/pharmaceutics16040442
  24. Junior JNA; Preto DD'; Lazarini MEZN; de Lima MA; Bonatelli M; Berardinelli GN; da Silva VD; et al. "PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site.". International journal of clinical oncology (2024): http://europepmc.org/abstract/med/38528294.
    10.1007/s10147-024-02494-3
  25. Perdomo, Sandra; Abedi-Ardekani, Behnoush; de Carvalho, Ana Carolina; Ferreiro-Iglesias, Aida; Gaborieau, Valérie; Cattiaux, Thomas; Renard, Hélène; et al. "The Mutographs biorepository: A unique genomic resource to study cancer around the world". Cell Genomics (2024): 100500. http://dx.doi.org/10.1016/j.xgen.2024.100500.
    10.1016/j.xgen.2024.100500
  26. Pedro De Marchi; Leticia Ferro Leal; Luciane Sussuchi da Silva; Rodrigo de Oliveira Cavagna; Flavio Augusto Ferreira da Silva; Vinicius Duval da Silva; Eduardo CA da Silva; et al. "Gene expression profiles (GEPs) of immuno-oncologic pathways as predictors of response to checkpoint inhibitors in advanced NSCLC". Translational Oncology (2024): https://doi.org/10.1016/j.tranon.2023.101818.
    10.1016/j.tranon.2023.101818
  27. Lidia Maria Rebolho Batista Arantes; Renato José Silva-Oliveira; Ana Carolina de Carvalho; Matias Eliseo Melendez; Bruna Pereira Sorroche; Renan de Jesus Teixeira; Katiane Tostes; et al. "Unveiling the role of MGMT and DAPK hypermethylation in response to anti-EGFR agents: Molecular insights for advancing HNSCC treatment". Head & Neck (2023): https://doi.org/10.1002/hed.27602.
    10.1002/hed.27602
  28. Cíntia Regina Niederauer Ramos; Renato José Silva Oliveira; Marcela Nunes Rosa; Ariane Stéfani Pereira; Renata Barbosa Vahia de Abreu; Andre van Helvoort Lengert; Rui Manuel Reis; et al. "RAD50 Deficient in a Breast Cancer Model Predicts Sensitivity to PARP Inhibitors". Current Cancer Drug Targets (2023): https://doi.org/10.2174/1568009623666230418101511.
    10.2174/1568009623666230418101511
  29. Wesley Wang; Zeynep Temerit Kumm; Cindy Ho; Ideli Zanesco-Fontes; Gustavo Texiera; Rui Manuel Reis; Horacio Martinetto; et al. "Unsupervised machine learning models reveal predictive clinical markers of glioblastoma patient survival using white blood cell counts prior to initiating chemoradiation". Neuro-Oncology Advances (2023): https://doi.org/10.1093/noajnl/vdad140.
    10.1093/noajnl/vdad140
  30. de Oliveira C; Martins SFF; Gonçalves PG; Limone GA; Longatto-Filho A; Reis RM; Bidinotto LT. "Low EGFL7 expression is associated with high lymph node spread and invasion of lymphatic vessels in colorectal cancer.". Scientific reports (2023): http://europepmc.org/abstract/med/37957249.
    10.1038/s41598-023-47132-6
  31. Paula Rohr; Isabela Campanelli dos Santos; André van Helvoort Lengert; Marcos Alves de Lima; Rui Manuel Reis; Fernando Barbosa, Jr; Henrique Cesar Santejo Silveira. "Absolute telomere length in peripheral blood lymphocytes of workers exposed to construction environment". International Journal of Environmental Health Research (2023): https://doi.org/10.1080/09603123.2022.2066069.
    10.1080/09603123.2022.2066069
  32. Campanella NC; Gomes INF; Alves ALV; Leal LF; Evangelista AF; Rosa MN; Melendez ME; et al. "Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis.". Cancer cell international (2023): http://europepmc.org/abstract/med/37907993.
    10.1186/s12935-023-03102-6
  33. Oliveira AGS; Rocha MA; de Azevedo LS; Coelho ATM; Chagas RCR; Santos HB; Thomé RG; et al. "Tapirira guianensis is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in vivo.". Planta medica (2023): http://europepmc.org/abstract/med/37832581.
    10.1055/a-2181-2569
  34. Klein MO; Francisco LFV; Gomes INF; Serrano SV; Reis RM; Silveira HCS. "Hazard assessment of antineoplastic drugs and metabolites using cytotoxicity and genotoxicity assays.". Mutation research. Genetic toxicology and environmental mutagenesis (2023): http://europepmc.org/abstract/med/37973299.
    10.1016/j.mrgentox.2023.503704
  35. Moreno DA; Bonatelli M; Antoniazzi AP; de Paula FE; Leal LF; Garcia FAO; de Paula AE; et al. "High frequency of WNT-activated medulloblastomas with CTNNB1 wild type suggests a higher proportion of hereditary cases in a Latin-Iberian population.". Frontiers in oncology (2023): http://europepmc.org/abstract/med/37746264.
    10.3389/fonc.2023.1237170
  36. Fares AF; Li Y; Jiang M; Brown MC; Lam ACL; Aggarwal R; Schmid S; et al. "Association between duration of smoking abstinence before non-small-cell lung cancer diagnosis and survival: a retrospective, pooled analysis of cohort studies.". The Lancet. Public health (2023): http://europepmc.org/abstract/med/37633678.
    10.1016/s2468-2667(23)00131-7
  37. Santos FA; Reis RM; Barroti LC; Pereira AAL; Matsushita MM; de Carvalho AC; Datorre JG; Berardinelli GN; Araujo RLC. "Overall Survival, BRAF, RAS, and MSI Status in Patients Who Underwent Cetuximab After Refractory Chemotherapy for Metastatic Colorectal Cancer.". Journal of gastrointestinal cancer (2023): http://europepmc.org/abstract/med/37608030.
    10.1007/s12029-023-00964-x
  38. Adhara Brandão Lima; Mariana Bisarro dos Reis; Marcus Matsushita; Monise Tadin dos Reis; Marco Antônio de Oliveira; Rui Manuel Reis; Denise Peixoto Guimarães. "Combined SEPT9 and BMP3 methylation in plasma for colorectal cancer early detection and screening in a Brazilian population". Cancer Medicine (2023): https://doi.org/10.1002/cam4.6224.
    10.1002/cam4.6224
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  386. Almeida, M.I.; Reis, R.M.; Calin, G.A.; Almeida, M. I.; Reis, R. M.; Calin, G. A.. "MYC-microRNA-9-metastasis connection in breast cancer". Cell Research 20 6 (2010): 603-604. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953292594&partnerID=MN8TOARS.
    10.1038/cr.2010.70
  387. Costa, B.M.; Smith, J.S.; Chen, Y.; Chen, J.; Phillips, H.S.; Aldape, K.D.; Zardo, G.; et al. "Reversing HOXA9 oncogene activation by PI3K inhibition: Epigenetic mechanism and prognostic significance in human glioblastoma". Cancer Research 70 2 (2010): 453-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-76549121309&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-09-2189
  388. Almeida, M.I.; Reis, R.M.; Calin, G.A.; Almeida, M. I.; Reis, R. M.; Calin, G. A.. "MicroRNAs and metastases: The neuroblastoma link". Cancer Biology and Therapy 9 6 (2010): 453-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953717633&partnerID=MN8TOARS.
    11215 [pii]
  389. Gaspar, N.; Marshall, L.; Perryman, L.; Bax, D.A.; Little, S.E.; Viana-Pereira, M.; Sharp, S.Y.; et al. "MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature". Cancer Research 70 22 (2010): 9243-9252. http://www.scopus.com/inward/record.url?eid=2-s2.0-78549288561&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-10-1250
  390. Bax, D.A.; Mackay, A.; Little, S.E.; Carvalho, D.; Viana-Pereira, M.; Tamber, N.; Grigoriadis, A.E.; et al. "A distinct spectrum of copy number aberrations in pediatric high-grade gliomas". Clinical Cancer Research 16 13 (2010): 3368-3377. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954240113&partnerID=MN8TOARS.
    10.1158/1078-0432.CCR-10-0438
  391. Pinheiro, C.; Reis, R. M.; Ricardo, S.; Longatto-Filho, A.; Schmitt, F.; Baltazar, F.. "Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44.". J Biomed Biotechnol 2010 (2010): 427694-427694.
    10.1155/2010/427694
  392. Lima-Rodrigues, M.; Lamas, N.; Valle-Fernandes, A.; Cruz, A.; Vieira, A.; Oliveira, P.; Pedrosa, J.; et al. "The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment.". Inflamm Res 59 9 (2010): 743-53.
    10.1007/s00011-010-0185-5
  393. Longatto-Filho, A.; Pinheiro, C.; Martinho, O.; Moreira, M.A.R.; Ribeiro, L.F.J.; Queiroz, G.S.; Schmitt, F.C.; et al. "Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma". BMC Cancer 9 (2009): 212-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651093726&partnerID=MN8TOARS.
    10.1186/1471-2407-9-212
  394. Martinho, O.; Gouveia, A.; Viana-Pereira, M.; Silva, P.; Pimenta, A.; Reis, R.M.; Lopes, J.M.; Reis, R. M.; Lopes, J. M.. "Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs". Histopathology 55 1 (2009): 53-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-68049123582&partnerID=MN8TOARS.
    10.1111/j.1365-2559.2009.03323.x
  395. Longatto Filho, A.; Gonçalves, A.E.P.; Martinho, O.; Schmitt, F.C.; Reis, R.M.. "Liquid-based cytology in DNA-based molecular research viability and potential application". Analytical and Quantitative Cytology and Histology 31 6 (2009): 395-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-74549114803&partnerID=MN8TOARS.
  396. Pinto, C.; Veiga, I.; Pinheiro, M.; Peixoto, A.; Pinto, A.; Lopes, J. M.; Reis, R. M.; et al. "TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset.". Fam Cancer 8 4 (2009): 383-90.
    10.1007/s10689-009-9251-y
  397. Martinho, O.; Longatto-Filho, A.; Lambros, M. B.; Martins, A.; Pinheiro, C.; Silva, A.; Pardal, F.; et al. "Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.". Br J Cancer 101 6 (2009): 973-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-70249091030&partnerID=MN8TOARS.
    6605225 [pii]10.1038/sj.bjc.6605225
  398. Viana-Pereira, M.; Almeida, I.; Sousa, S.; Mahler-Araújo, B.; Seruca, R.; Pimentel, J.; Reis, R. M.; Reis, R.M.. "Analysis of microsatellite instability in medulloblastoma.". Neuro Oncol 11 5 (2009): 458-67. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349622987&partnerID=MN8TOARS.
    15228517-2008-115 [pii]10.1215/15228517-2008-115
  399. Bax, D. A.; Gaspar, N.; Little, S. E.; Marshall, L.; Perryman, L.; Regairaz, M.; Viana-Pereira, M.; et al. "EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines.". Clin Cancer Res 15 18 (2009): 5753-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349456789&partnerID=MN8TOARS.
    1078-0432.CCR-08-3210 [pii]10.1158/1078-0432.CCR-08-3210
  400. Bax, D. A.; Little, S. E.; Gaspar, N.; Perryman, L.; Marshall, L.; Viana-Pereira, M.; Jones, T. A.; et al. "Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.". PLoS One 4 4 (2009): e5209-e5209.
    10.1371/journal.pone.0005209
  401. Martinho, O.; Gouveia, A.; Silva, P.; Pimenta, A.; Reis, R. M.; Lopes, J. M.. "Loss of RKIP expression is associated with poor survival in GISTs.". Virchows Arch 455 3 (2009): 277-84.
    10.1007/s00428-009-0821-z
  402. Baruchel, S.; Sharp, J. R.; Bartels, U.; Hukin, J.; Odame, I.; Portwine, C.; Strother, D.; et al. "A Canadian paediatric brain tumour consortium (CPBTC) phase II molecularly targeted study of imatinib in recurrent and refractory paediatric central nervous system tumours.". Eur J Cancer 45 13 (2009): 2352-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-68749098341&partnerID=MN8TOARS.
    S0959-8049(09)00348-7 [pii]10.1016/j.ejca.2009.05.008
  403. Manuel Lima-Rodrigues; Ana Valle-Fernandes; Nuno Lamas; Andrea Cruz; Fátima Baltazar; Fernanda Milanezi; Rui Nunes; et al. "A New Model of Laryngitis: Neuropeptide, Cyclooxygenase, and Cytokine Profile". Laryngoscope 118 1 (2008): 78-86. http://dx.doi.org/10.1097/mlg.0b013e3181492400.
    10.1097/mlg.0b013e3181492400
  404. Gomes, A.L.; Gouveia, A.; Capelinha, A.F.; De La Cruz, D.; Silva, P.; Reis, R.M.; Pimenta, A.; et al. "Molecular alterations of KIT and PDGFRA in GISTs: Evaluation of a Portuguese series". Journal of Clinical Pathology 61 2 (2008): 203-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-38849209234&partnerID=MN8TOARS.
    10.1136/jcp.2007.047043
  405. Viana-Pereira, M.; Lopes, J.M.; Little, S.; Milanezi, F.; Basto, D.; Pardal, F.; Jones, C.; Reis, R.M.. "Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas". Anticancer Research 28 2 A (2008): 913-920. http://www.scopus.com/inward/record.url?eid=2-s2.0-42549104976&partnerID=MN8TOARS.
  406. Martinho, O.; Gonçalves, A.; Moreira, M.A.R.; Ribeiro, L.F.J.; Queiroz, G.S.; Schmitt, F.C.; Reis, R.M.; et al. "KIT activation in uterine cervix adenosquamous carcinomas by KIT / SCF autocrine/paracrine stimulation loops". Gynecologic Oncology 111 2 (2008): 350-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-55849112592&partnerID=MN8TOARS.
    10.1016/j.ygyno.2008.07.011
  407. Lima-Ramos, V.; Pacheco-Figueiredo, L.; Costa, S.; Pardal, F.; Silva, A.; Amorim, J.; Lopes, J. M.; et al. "TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant therapy response of gliomas.". Cancer Genet Cytogenet 180 1 (2008): 14-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749023402&partnerID=MN8TOARS.
    S0165-4608(07)00586-9 [pii]10.1016/j.cancergencyto.2007.08.019
  408. Buffart, T.E.; Carvalho, B.; Mons, T.; Reis, R.M.; Moutinho, C.; Silva, P.; van Grieken, N.C.T.; et al. "DNA copy number profiles of gastric cancer precursor lesions". BMC Genomics 8 (2007): 345-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249020215&partnerID=MN8TOARS.
    10.1186/1471-2164-8-345
  409. Schmitt, F.C.; Gomes, A.L.; Milanezi, F.; Reis, R.; Bardales, R.H.. "Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration". Minerva Medica 98 4 (2007): 385-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749056265&partnerID=MN8TOARS.
  410. Gomes, A.L.; Reis-Filho, J.S.; Lopes, J.M.; Martinho, O.; Lambros, M.B.K.; Martins, A.; Schmitt, F.; Pardal, F.; Reis, R.M.. "Molecular alterations of KIT oncogene in gliomas". Cellular Oncology 29 5 (2007): 399-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547858153&partnerID=MN8TOARS.
  411. Gomes, A.L.; Bardales, R.H.; Milanezi, F.; Reis, R.M.; Schmitt, F.; Gomes, A. L.; Bardales, R. H.; Reis, R. M.. "Molecular analysis of c-Kit and PDGFRA in GISTs diagnosed by EUS". American Journal of Clinical Pathology 127 1 (2007): 89-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249077294&partnerID=MN8TOARS.
    10.1309/M1EC8JE9ACAMJACU
  412. Costa, B.M.; Ferreira, P.; Costa, S.; Canedo, P.; Oliveira, P.; Silva, A.; Pardal, F.; et al. "Association between functional EGF+61 polymorphism and glioma risk". Clinical Cancer Research 13 9 (2007): 2621-2626. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249104304&partnerID=MN8TOARS.
    10.1158/1078-0432.CCR-06-2606
  413. Carvalho, B.; Buffart, T.E.; Reis, R.M.; Mons, T.; Moutinho, C.; Silva, P.; Van Grieken, N.C.T.; et al. "Mixed gastric carcinomas show similar chromosomal aberrations in both their diffuse and glandular components". Cellular Oncology 28 5-6 (2006): 283-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845636631&partnerID=MN8TOARS.
  414. Reis-Filho, J. S.; Pinheiro, C.; Lambros, M. B.; Milanezi, F.; Carvalho, S.; Savage, K.; Simpson, P. T.; et al. "EGFR amplification and lack of activating mutations in metaplastic breast carcinomas.". J Pathol 209 4 (2006): 445-53.
    10.1002/path.2004
  415. Sambade, C.; Berglund, M.; Lagercrantz, S.; Sällström, J.; Reis, R. M.; Enblad, G.; Glimelius, B.; Sundström, C.. "U-2940, a human B-cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma.". Int J Cancer 118 3 (2006): 555-63.
    10.1002/ijc.21417
  416. Reis, R.M.; Reis-Filho, J.S.; Filho, A.L.; Tomarev, S.; Silva, P.; Lopes, J.M.; Reis, R. M.; et al. "Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors". Pathology Research and Practice 201 12 (2005): 771-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-30444456045&partnerID=MN8TOARS.
    10.1016/j.prp.2005.08.010
  417. Carvalho, I.; Milanezi, F.; Martins, A.; Reis, R. M.; Schmitt, F.; Reis, R.M.. "Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression.". Breast Cancer Res 7 5 (2005): R788-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644873490&partnerID=MN8TOARS.
    bcr1304 [pii]10.1186/bcr1304
  418. Basto, D.; Trovisco, V.; Lopes, J. M.; Martins, A.; Pardal, F.; Soares, P.; Reis, R. M.. "Mutation analysis of B-RAF gene in human gliomas.". Acta Neuropathol 109 2 (2005): 207-10.
    10.1007/s00401-004-0936-x
  419. Reis, R.M.; Martins, A.; Ribeiro, S.A.; Basto, D.; Longatto-Filho, A.; Schmitt, F.C.; Lopes, J.M.. "Molecular characterization of PDGFR-a/PDGF-A and c-KIT/SCF in gliosarcomas". Cellular Oncology 27 5-6 (2005): 319-326. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244460120&partnerID=MN8TOARS.
  420. REIS, RUI; Lopes, José Manuel. "Genetic alterations of adult and paediatric astrocytic tumours". Revista de Neurología 38 (2004): 8-15.
    Publicado
  421. Reis, R.M.; Nakamura, M.; Masuoka, J.; Watanabe, T.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas". Acta Neuropathologica 101 4 (2001): 297-304. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035032855&partnerID=MN8TOARS.
  422. Reis, R.M.; Herva, R.; Brandner, S.; Koivukangas, J.; Mironov, N.; Bär, W.; Kleihues, P.; Ohgaki, H.. "Second primary glioblastoma". Journal of Neuropathology and Experimental Neurology 60 2 (2001): 208-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035111348&partnerID=MN8TOARS.
  423. Reis, R.M.; Hara, A.; Kleihues, P.; Ohgaki, H.. "Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas". Acta Neuropathologica 102 5 (2001): 422-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034774966&partnerID=MN8TOARS.
  424. Reis, R.M.; Nakamura, M.; Masuoka, J.; Watanabe, T.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Erratum: Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas (Acta Neuropathologica (2001) vol. 101 (297-304))". Acta Neuropathologica 101 6 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034914191&partnerID=MN8TOARS.
  425. Rui M. Reis; Dilek Könü-Lebleblicioglu; Jose Manuel Lopes; Paul Kleihues; Hiroko Ohgaki. "Genetic Profile of Gliosarcomas". The American Journal of Pathology 156 2 (2000): 425-432. http://dx.doi.org/10.1016/s0002-9440(10)64746-3.
    10.1016/s0002-9440(10)64746-3
  426. Fujisawa, H.; Reis, R.M.; Nakamura, M.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas". Laboratory Investigation 80 1 (2000): 65-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033968345&partnerID=MN8TOARS.
  427. Alves, C.; Silva, F.; Gusmão, L.; Seruca, R.; Soares, P.; Reis, R. M.; Amorim, A.. "Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: characterisation in a normal population and in thyroid and gastric tumours.". Eur J Hum Genet 8 7 (2000): 540-4.
    10.1038/sj.ejhg.5200486
  428. Huang, H.; Reis, R.; Yonekawa, Y.; Lopes, J.M.; Kleihues, P.; Ohgaki, H.. "Identification in human brain tumors of DNA sequences specific for SV40 large T antigen". Brain Pathology 9 1 (1999): 33-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032958518&partnerID=MN8TOARS.
  429. Fujisawa, H.; Kurrer, M.; Reis, R. M.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.". Am J Pathol 155 2 (1999): 387-94.
    S0002-9440(10)65135-8 [pii]10.1016/S0002-9440(10)65135-8
Capítulo de livro
  1. Cardoso-Carneiro, Diana; Raquel-Cunha, Ana; Pinheiro, Joana; Gabriela-Freitas, Maria; Fontão, Patrícia; Reis, Rui M.; Martinho, Olga; et al. "Implications of RKIP protein in cancer prognosis and therapy response: A literature update". In Prognostic and Therapeutic Applications of RKIP in Cancer, 389-414. Elsevier, 2020.
    Publicado • 10.1016/b978-0-12-819612-0.00020-1
  2. Santana, IV; da Silva, V; REIS, RUI. "Classificação Molecular do Câncer de Mama". In Câncer de Mama: Uma Filosofia de Tratamento - Breast Unit Barretos, 204-209. Thieme Revinter, 2018.
    Publicado
  3. De Mello, Ramon Andrade; Luis, Michael; Araújo, António; Reis, Rui Manuel; Hespanhol, Venceslau. "The Role of Angiogenesis in Non-small Cell Lung Cancer Tumor Behavior". In Biochemical Basis and Therapeutic Implications of Angiogenesis, 217-239. Springer International Publishing, 2017.
    Publicado • 10.1007/978-3-319-61115-0_10
  4. Fernandes, Ana C.; Caeiro, Cláudia; Miranda-Gonçalves, Vera; Cury, Fernanda; Damasceno, Margarida; REIS, RUI; Martinho, Olga. "Bevacizumab for Glioblastoma Treatment: Reviewing Biological and Clinical Hypothesis for its Success and Failures". In Anti-Angiogenesis Drug Discovery and Development, 175-226. Bentham Science Publishers, 2016.
    Publicado • 10.2174/9781681081557116030007
  5. Gonçalves, Vera Miranda; Baltazar, Fátima; Reis, Rui Manuel. "Brain Tumor Metabolism — Unraveling Its Role in Finding New Therapeutic Targets". In Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor, 83. InTech, 2015.
    Publicado • 10.5772/59606
  6. Paixao Becker, Aline; Scapulatempo-Neto, Cristovam; Neder, Luciano; Chimelli, Leila; Reis, Rui M.. "Pilocytic Astrocytoma: Anatomic, Pathological and Molecular Aspects". In Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors, 127-143. InTech, 2013.
    Publicado • 10.5772/53956
  7. de Mello, Ramon Andrade; Luis, Michael; Araújo, António; Reis, Rui Manuel; Hespanhol, Venceslau. "Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small-Cell Lung Cancer Tumor Behavior: Implications in Risk Assessment and Clinical Outcome". In Biochemical Basis and Therapeutic Implications of Angiogenesis, 381-403. Springer, New York, 2013.
    Publicado • 10.1007/978-1-4614-5857-9_20
  8. Viana-Pereira, Marta; Jones, Chris; Reis, Rui Manuel. "Pediatric High-Grade Glioma: Role of Microsatellite Instability". In Pediatric Cancer: Diagnosis, Therapy and Prognosis, 205-210. Springer, Dordrecht, 2012.
    Publicado • 10.1007/978-94-007-4528-5_22
  9. Nogueira-de-Souza, Naiara Correa; Almeida, José Reinaldo; Serrano, Sérgio V.; REIS, RUI. "BRAF in glioblastomas: Clinical implications". In Glioblastoma: Risk Factors, Diagnosis and Treatment Options, 227-240. Nova Science Publishers, Inc., 2012.
    Publicado
  10. Becker, AP; Caravina, G; Clara, C; REIS, RUI. "The Role of Immunohistochemistry in the Diagnostic and Prognostic of Glioblastoma Patients". In Glioblastoma: Risk Factors, Diagnosis and Treatment Options, 173-199. Nova Science Publishers, 2012.
    Publicado
  11. Martinho, Olga; Reis, Rui Manuel. "Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA)". In Tumors of the Central Nervous System, 109-118. Springer, Dordrecht, 2011.
    Publicado • 10.1007/978-94-007-0344-5_12
  12. Viana-Pereira, Marta; Jones, Chris; Reis, Rui M.. "Genetic Instability in Paediatric and Adult Brain Tumours". In Molecular Targets of CNS Tumors, 19. InTech, 2011.
    Publicado • 10.5772/19571
  13. Ohgaki, H.; Biernat, W.; REIS, RUI; Hegi, M.; Kleihues, P.. "Gliosarcoma". In WHO Classification of Tumours. Pathology and Genetics of Tumours of the Nervous System, 42-44. IARC Press, 2000.
    Publicado
Poster em conferência
  1. Daniel Moreno; Murilo Bonatelli; Flávia E. de Paula; Gustavo Teixeira; Iara Santana; Fabiano Saggioro; Luciano Neder; et al. "Alta frequência de meduloblastomas WNT CTNNB1 tipo selvagem sugere maior proporção de casos hereditários na população latino-ibérica". Trabalho apresentado em XVIII CONGRESSO BRASILEIRO e XXXIV CONGRESSO LATINO-AMERICANO DE ONCOLOGIA PEDIÁTRICA, 2023.
  2. Raquel-Cunha, Ana; Pinheiro, Joana; Cardoso-Carneiro, Diana; Fontão, Patrícia; Gabriela-Freitas, Maria; Reis, Rui Manuel; Martinho, Olga. "Untangling the role of RKIP in NSCLC aggressiveness: an in vitro /in vivo and in silico analysis". Trabalho apresentado em II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer, 2021.
  3. Sónia Pires-Celeiro; Baltazar, Fátima; Reis, Rui Manuel; Viana-Pereira, Marta. "SPINT2: a potential biomarker for melanoma patients". Trabalho apresentado em II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  4. Raquel-Cunha, Ana; Pinheiro, Joana; Cardoso-Carneiro, Diana; Fontão, Patrícia; Gabriela-Freitas, Maria; Reis, Rui Manuel; Martinho, Olga. "A proteína RKIP como um novo preditor de resposta a terapias anti-EGFR em cancro do pulmão". Trabalho apresentado em 3º Encontro Nacional de Jovens Investigadoresem Oncologia, 2021.
  5. Fontão, Patrícia; Raquel-Cunha, Ana; Cardoso-Carneiro, Diana; Pinheiro, Joana; Gabriela-Freitas, Maria; Mendes, Adriana; Reis, Rui Manuel; Martinho, Olga. "Fator de transcrição embrionário T-boxBrachyury como biomarcador de resposta e alvo terapêutico em cancro do pulmão". Trabalho apresentado em 3º Encontro Nacional de Jovens Investigadoresem Oncologia, 2021.
  6. Cardoso-Carneiro, Diana; Raquel-Cunha, Ana; Fontão, Patrícia; Pinheiro, Joana; Gabriela-Freitas, Maria; Nogueira, Rosete; Reis, Rui Manuel; Martinho, Olga. "Compreender a regulação e sinalização da RKIP no cancro do colo do útero: RKIP/HER loop". Trabalho apresentado em 3º Encontro Nacionalde Jovens Investigadoresem Oncologia, 2021.
  7. Fontão, Patrícia; Raquel-Cunha, Ana; Cardoso-Carneiro, Diana; Pinheiro, Joana; Gabriela-Freitas, Maria; Mendes, Adriana; Reis, Rui Manuel; Martinho, Olga. "Exploring the predictive andtherapeutic value of the embryonic T-box transcription factor Brachyury in lung cancer". Trabalho apresentado em II ASPIC-ASEICA International Meeting -Current Trends in Precision Medicine in Cancer, 2021.
  8. Sónia Pires-Celeiro; Fátima Balazar; Reis, Rui Manuel; Marta Viana-Pereira. "SPINT2 downregulation in Melanoma influences EMT". Trabalho apresentado em EACR 2021 Virtual Congress, 2021.
  9. Fontão, Patrícia; Raquel-Cunha, Ana; Cardoso-Carneiro, Diana; Pinheiro, Joana; Gabriela-Freitas, Maria; Mendes, Adriana; Martinho, Olga; Reis, Rui Manuel. "Embryonic T-box transcription factor Brachyury as a predictive biomarker andtherapeutic target in lung cancer". Trabalho apresentado em 27th Porto CancerMeeting – Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  10. Costa, AM; Martins, F; Oliveira, R.; Cavadas, B; Pinto, F; Cardoso, P; Castro, F; et al. "Modulation of macrophage-cancer cell interaction by the hypoxic colon cancer microenvironment.". Trabalho apresentado em I ASEICA-ASPIC International Meeting, 2019.
  11. Martins, F; Oliveira, R.; Cavadas, B; Pinto, F; Cardoso, AP; Castro, F; Loureiro, JP; et al. "Hypoxia alters colon cancer macrophage-cancer cell interactions.". Trabalho apresentado em SICR 2019 – Symposium on Immunomodulation in Cancer & Regeneration, 2019.
  12. Oliveira, R.; Martins, F; Cavadas, Bruno; Pinto, F; Cardoso, AP; Castro, F; Loureiro, JP; et al. "Colon cancer hypoxic ecosystem alters macrophage-cancer cell interactions.". Trabalho apresentado em 26th Porto Cancer Meeting, 2019.
  13. Lima, Jorge; Reis, Rui Manuel; Catarino, Telmo; Peixoto, Joana; Vinagre, João; Batista, Rui; Castro, Ligia; et al. "Abstract C118: TERT promoter mutations in human gliomas.". Trabalho apresentado em AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, 2013.
Pré-impressão
  1. Diaz-Gay M; dos Santos W; Moody S; Kazachkova M; Abbasi A; Steele CD; Vangara R; et al. "Geographic and age-related variations in mutational processes in colorectal cancer". 2025. http://europepmc.org/abstract/PPR/PPR981289.
    10.1101/2025.02.13.25322219
  2. Torrens L; Moody S; de Carvalho AC; Kazachkova M; Abedi-Ardekani B; Cheema S; Senkin S; et al. "The Complexity of Tobacco Smoke-Induced Mutagenesis in Head and Neck Cancer". 2024. http://europepmc.org/abstract/PPR/PPR838403.
    10.1101/2024.04.15.24305006
  3. Junior JNA; Preto DD; Lazarini MEZN; de Lima MA; Bonatelli M; Berardinelli GN; Silva VDd; et al. "PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site". 2023. http://europepmc.org/abstract/PPR/PPR765319.
    10.21203/rs.3.rs-3369856/v1
  4. Senkin S; Moody S; Díaz-Gay M; Abedi-Ardekani B; Cattiaux T; Ferreiro-Iglesias A; Wang J; et al. "Geographic variation of mutagenic exposures in kidney cancer genomes". 2023. http://europepmc.org/abstract/PPR/PPR683557.
    10.1101/2023.06.20.23291538
  5. Melendez ME; Silva-Oliveira RJ; Evangelista AF; Pelloso ARA; Arantes LMR; Reis RM; De Carvalho AC; Carvalho AL. "Biological and molecular characterization of HCB-289: a Brazilian head and neck cancer stem-like cell line". 2023. http://europepmc.org/abstract/PPR/PPR650507.
    10.21203/rs.3.rs-2787430/v1
  6. Wang W; Kumm ZT; Ho C; Zanesco-Fontes I; Texiera G; Reis RM; Martinetto H; et al. "Unsupervised machine learning models reveal predictive markers of glioblastoma patient survival using white blood cell counts prior to initiating chemoradiation". 2023. http://europepmc.org/abstract/PPR/PPR648892.
    10.21203/rs.3.rs-2834239/v1
  7. Vicente ALSA; Novoloaca A; Cahais V; Awada Z; Cuenin C; Spitz N; Carvalho AL; et al. "Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure". 2022. http://europepmc.org/abstract/PPR/PPR500672.
    10.1101/2022.05.30.22275777
  8. Evangelista AF; Oliveira RJ; Silva VAO; Vieira RADC; Reis RM; Marques MMC. "Integrative analysis of mRNA and miRNA pro¿les identifies miR-193 and miR-210 as potential regulatory biomarkers in di¿erent molecular subtypes of breast cancer". 2021. http://europepmc.org/abstract/PPR/PPR267280.
    10.21203/rs.3.rs-47634/v2
  9. Santos Wd; Reis MBd; Porto J; Carvalho ACd; Matsushita M; Oliveira G; Syrjänen K; Reis RM; Guimaraes D. "Somatic targeted mutation profiling of colorectal cancer precursor lesions". 2021. http://europepmc.org/abstract/PPR/PPR314864.
    10.21203/rs.3.rs-428174/v1
Resumo em conferência
  1. Costa, Ângela Margarida; Martins, Flávia; Oliveira, Rosa; Pinto, Filipe; Castro, Flávia; Cardoso, Ana Patrícia; Cavadas, Bruno; et al. "The hypoxia impact in the macrophage-driven cancer cell invasive phenotype". Trabalho apresentado em 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention, Lisbon, 2018.
    Publicado
  2. Viana Pereira, M; Martinho, O; Lopes, JM; Mahler Araujo, B; Pimentel, JG; Reis, RM. "Absence of KIT gene mutations and amplification in medulloblastomas". 2008.
  3. Martinho, O; Gouveia, A; Viana Pereira, M; Silva, P; Pimenta, A; Reis, RM; Lopes, JM. "Analysis of MAP kinase signalling pathway in KIT & PDGFRA wild-type GISTs". 2008.
    10.1016/s1359-6349(08)72517-5
  4. Gomes, Ana L.; Reis-Filho, J.S.; Lopes, José Manuel; Lambros, M.; Martins, Albino; Schmitt, Fernando; Pardal, F.; Reis, Rui Manuel. "Study of molecular mechanisms underlying oncogenic c-Kit overexpression in gliomas.". Trabalho apresentado em XLI Congress of the Portuguese Society for Microscopy,, Braga, 2006.

Outros

Outra produção
  1. Molecular Profile of Driver Genes in Lung Adenocarcinomas of Brazilian Patients Who Have Never Smoked: Implications for Targeted Therapies.. 2024. Rui Manuel Reis; Rodrigo de Oliveira Cavagna; Flavia Escremim de Paula; Gustavo Noriz Berardinelli; Murilo Bonatelli; Iara Santana; Eduardo Caetano Albino da Silva; et al. https://doi.org/10.1093/oncolo/oyae129.
    10.1093/oncolo/oyae129
  2. Integrative analysis of mRNA and miRNA pro¿les identifies miR-193 and miR-210 as potential regulatory biomarkers in di¿erent molecular subtypes of breast cancer. 2020. Evangelista AF; Oliveira RJ; Silva VAO; Vieira RADC; Reis RM; Marques MMC. http://europepmc.org/abstract/PPR/PPR200593.
    10.21203/rs.3.rs-47634/v1
  3. Frequency of HPV detection in chagasic megaesophagus associated or not with esophageal squamous cell carcinoma. 2020. Munari FF; Sichero L; Cruvinel-Carloni A; Lacerda CF; Nunes EM; Oliveira ATTd; Scapulatempo-Neto C; et al. http://europepmc.org/abstract/PPR/PPR185754.
    10.21203/rs.3.rs-18204/v2
  4. HPV detection within a case series of chagasic megaesophagus associated or not with esophageal squamous cell carcinoma. 2020. Longatto-Filho A; Munari F; Sichero L; Cruvinel-Carloni A; Lacerda C; Nunes E; Oliveira A; et al. http://europepmc.org/abstract/PPR/PPR122149.
    10.21203/rs.3.rs-18204/v1
  5. Potential biomarkers of ductal carcinoma in situ progression. 2020. Dettogni RS; Stur E; Laus AC; Vieira RAdC; Marques MMC; Santana IVV; Pulido JZ; et al. http://europepmc.org/abstract/PPR/PPR132630.
    10.21203/rs.2.16192/v2
  6. Squamous differentiation portends poor prognosis in low and intermediate-risk endometrioid endometrial cancer. 2019. de Andrade DAP; da Silva VD; de Macedo Matsushita G; Alves de Lima M; de Andrade Vieira M; Cunha Andrade CEM; Luís Schmidt R; Reis RM; Reis Rd. http://europepmc.org/abstract/PPR/PPR85175.
    10.1101/698316
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/07/01 - Atual RKIP-regulated miRNAs in Gastrointestinal Stromal Tumor (GIST
Orientador
Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - Atual Identification of the gene expression profile in metastatic renal cell carcinomas treated with sunitinib and its predictive response value
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2019 - Atual Design and Implementation of an Integrated Lung Cancer Screening and Prevention Program using Mobile Computed Tomography
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2019 - Atual Methylation analysis of tumor suppressor genes SEPT9, NDRG4 and BMP3 in the plasma of participants in the colorectal cancer screening program at the Barretos Cancer Hospital
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2019 - Atual Development and implementation of a control and process management system for the medical and multiprofessional home secretary
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2019 - Atual RKIP protein as a novel predictor of EGFR targeted therapy response in lung cancer
Coorientador
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Hospital de Amor, Brasil
2018 - Atual Development of a gene expression panel to predict lymph node involvement in patients with non-small cell lung cancer
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - Atual Applicability of a nomogram including clinical and molecular variables in the stratification of risk groups in pediatric medulloblastoma
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - Atual Identification of predictive biomarkers of response to treatment with temozolomide in glioblastoma
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - Atual Analysis of somatic changes in the number of DNA copies of renal clear cell carcinoma
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - Atual RKIP protein as metastatic and therapeutic biomarker in cervical cancer
Coorientador
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Hospital de Amor, Brasil
2018 - Atual Molecular Profile Identification Associated With Response To Treatment With Immunological Checkpoints Inhibitors In Patients With Non-Small Cell Lung Cancer
Orientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2017 - Atual Study Of Biomarkers Response To Cetuximabe And Perspectives For The Use Of Anti-Egfr Combi-Molecules In Solid Tumors
Orientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2017 - Atual Recommended Low Risk Endometric Adenocarcinoma. Is There A Predictive Genetic Signature For This Population?
Coorientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2017 - Atual Evaluation Of Braf Mutation As A Predictive Factor Of Benefit To Chemotherapy In Patients With Metastatic Or Locally Advanced Irresectable Cancer Treated With Cetuximab In The Barretos Cancer Hospital
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2015 - Atual Molecular characterization of MTAP (Methylthioadenosine phosphorylase) and evaluation of its therapeutic potential in gliomas
Orientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2022/01/02 - 2033/12/30 Characterization and biological impact of medulloblastomas immune profile
Orientador
Oncology (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/12/01 - 2026/12/31 Risco Genético de Cancro Colorretal Esporádico na Região do Minho: Um Estudo GWAS (Genome-Wide Association Study)
Orientador
Oncology (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - 2023 ValidaçãO de biomarcadores preditivos da resposta à temozolomida em glioblastomas.
Orientador de Ideli Zanesco Fontes Baptista
Hospital de Amor, Brasil
2020 - 2023 Caracterização do efeito biológico do composto semissintético derivado de Euphorbia tirucalli in vitro e in vivo, a partir do estabelecimento de um modelo xenográfico derivado de pacientes com câncer de esôfago.
Orientador de Ana Laura Vieira Alves
Hospital de Amor, Brasil
2020 - 2023 Avaliação da frequência e impacto clínico das laterações moleculares “drivers” em 1000 pacientes com c6ancer de pulmão de células não pequenas tratados no Hospital de Câncer de Barretos.
Orientador de Rodrigo de Oliveira Cavagna
Hospital de Amor, Brasil
2020 - 2022 Associação da instabilidade de microssatélites (MSI) e vírus Epstein-Barr (EBV) com a resposta patológica em pacientes com adenocarcinoma gástrico submetidos a quimioterapia perioperatória com Flofox e Flot.
Orientador de Diego Burgardt
Hospital de Amor, Brasil
2020 - 2022 Análise de Brotamento Tumoral como fator prognóstico em pacientes com carcinoma colorretal do Hospital de Câncer de Barretos.
Orientador de Monise Tadin Reis
Hospital de Amor, Brasil
2016 - 2020 In vitro and in vivo characterization of the antineoplastic potential of natural plant extracts and derivatives in commercial and primary cervical tumor lines
Orientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2018 - 2019 New Diagnostic Method for Detecting Alk / Ret / Ros1 Fusions in Patients with Lung Adenocarcinoma Without Mutations in Kras and Egfr Genes
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2018 - 2019 Dissecting chemotherapy resistance in prostate cancer: interplay between RKIP and androgen stimulation
Coorientador
Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2019 Characterization of the involvement of the WNK2 protein in autophagic and endocytic vesicular traffic in gliomas
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2017 - 2019 Evaluation of expression and prognostic potential of genes present in the chr9p22.1-p21.3 locus in gliomas
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2017 - 2019 Analysis of the frequency of BRAF gene mutations and association with clinicopathological characteristics of patients with lung adenocarcinoma for future direction of clinical management with target therapy
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2017 - 2019 Post-doc supervision of Nathalia Campanella (FAPESP Fellowship)
Orientador
Hospital de Amor, Brasil
2016 - 2019 Analysis of the hypermethylation profile of a panel of tumor suppressor genes in precursor lesions and colorectal cancer
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2016 - 2019 Mutational profile of an extensive panel of oncogenes and tumor suppressor genes in colorectal cancer and its precursor lesions
Coorientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2015 - 2019 Post-Doc Supervision of Olga Martinho (FCT Fellowship)
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018 Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma
Coorientador
Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018 Post-doc supervision of Juliana Alves Uzuelli (FAPESP Fellowship)
Orientador
Hospital de Amor, Brasil
2017 - 2018 Evaluation of potential RKIP and SDHB biomarkers in gastrointestinal stromal tumors (GISTs)
Orientador
Hospital de Amor, Brasil
2016 - 2018 Genotypic frequency of the EGF + 61 A> G polymorphism and analysis of associated melanoma risk in a miscigenic population
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2016 - 2018 Detection of high-risk HPV DNA and analysis of the mutational status of the KRAS and PIK3Ca genes and the inflammatory cytokine panel in patients with esophageal cancer and chagasic megaesophagus with and without cancer
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2016 - 2018 Application of visual programming analysis methods to cervical cancer data from The Cancer Genome Atlas
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2011 - 2018 Post-Doc Supervision of Marta Viana Pereira (FCT Fellowship)
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2017 Epidemiological, clinical-pathological and therapeutic characterization and its correlation with the ethnic ancestry of Brazilian patients with colorectal cancer
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2015 - 2017 Evaluation Of Anti-Tumoral Partitioning Activity And Chlorophormal Fractions Of Miconia Chamissois naudin In Human Glioma Lines
Coorientador
Biotechnology (Mestrado)
Universidade Federal de São João del-Rei, Brasil
2015 - 2017 Evaluation of the antineoplastic activity of enriched fractions of Annona coroacea Mart. in gynecological strains
Coorientador
Biotechnology (Mestrado)
Universidade Federal de São João del-Rei, Brasil
2015 - 2017 Post-doc supervision of Carla Carolina Munari (CNPq Fellowship)
Orientador
Hospital de Amor, Brasil
2013 - 2017 Elucidation of the molecular and clinical impact of microsatellite instability in patients with sporadic colorectal carcinoma at the Barretos Cancer Hospital.
Orientador
Oncolgy (Doutoramento)
Hospital de Amor, Brasil
2014 - 2016 Expression of the AXL tyrosine kinase receptor in patients with metastatic renal cell carcinoma treated with sunitinib and its association with clinical and pathological outcomes
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2014 - 2016 Characterization of the antineoplastic potential of natural compounds and their derivatives in commercial, primary and brain tumor stem cells
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2014 - 2016 Mutational Characterization of KRAS and BRAF Oncogenes and Analysis of MSI in Precursor Lesions of Colorectal Cancer
Coorientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2014 - 2016 Monocarboxylate Transporters in gliomas: regulation and therapeutic implications
Coorientador
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014 - 2016 Study of prognostic and therapeutic response biomarkers in gastrointestinal stromal tumors (GISTs)
Orientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2012 - 2016 Identification of new predictive biomarkers of the response to anti-EGFR therapy in solid tumors.
Orientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2011 - 2016 Learning from the embryo: Understanding early embryonic T gene – Brachyury – impact in human tumorigenesis
Orientador
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2015 Post-doc supervision of Giovanna Barbarini Longato (CNPq Fellowship)
Orientador
Hospital de Amor, Brasil
2014 - 2015 Study of Mutations of the HDI-1 Gene in Gliomas
Orientador
Hospital de Amor, Brasil
2014 - 2015 Potentiation studies of Eufol compost derived from the Euphorbia tirucalli plant encapsulated in zeolites as drug delivery systems for in vitro models of brain tumors
Orientador
Hospital de Amor, Brasil
2013 - 2015 Post-Doc Supervision of Renata Costa Camargo (CNPq fellowship)
Orientador
Hospital de Amor, Brasil
2012 - 2015 Assessment of the MAPK pathway in the oncogenesis of pilocytic astrocytomas
Orientador
Oncology (Doutoramento)
Hospital de Amor, Brasil
2014 - 2014 Post-doc supervision of Rosana Antunes Silveira (CAPES Fellowship)
Orientador
Hospital de Amor, Brasil
2012 - 2014 Post-doc supervision of Viviane Silva (Amazônia Fitomedicamentos Fellowship)
Orientador
Hospital de Amor, Brasil
2010 - 2014 Head and Neck Squamous Cell Carcinoma: integrating genomic, epigenetic and transcriptomic data - from bench to clinical applications
Coorientador
Health Sciences and Technology (Doutoramento)
Universidade de Coimbra, Portugal
2009 - 2014 Identification of intragenic copy number alterations and fusion genes in paediatric glioblastoma
Coorientador
Human Biology (Doutoramento)
Universidade de Coimbra, Portugal
2011 - 2013 Study of the tumor suppressor gene, TP53, in squamous cell carcinoma of the esophagus associated with chagasic megaesophagus
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2011 - 2013 Cytogenetic and Molecular characterization of Primary Glioma Strains
Orientador
Oncology (Mestrado)
Hospital de Amor, Brasil
2011 - 2013 Post-doc supervision of Lucas Tadeu Bidinotto (FAPESP Fellowship)
Orientador
Hospital de Amor, Brasil
2009 - 2013 Study of the Influence of Polymorphisms in the Angiogenesis Pathway in Lung Cancer
Coorientador
Human Biology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2012 Role of WNK2 protein kinase as a suppressor gene for malignant gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011 - 2012 Potential predictive biomarkers of anti-RTKs therapy response in gliomas: An in vitro and in vivo Study
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2012 microRNAs in cancer: biological effects of microRNAs in colorectal cancer
Orientador
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2012 Role of monocarboxylate transporters in the metabolic remodeling of glioblastomas
Coorientador
Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2012 Study of Biomarkers of Proliferation and Neovascularization: Clinical, Imagiological and Molecular Correlation
Coorientador
Clinical Sciences (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2012 Exploitation of monocarboxylate transporters (MCTs) as potential therapeutic targets in brain tumours
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2011 Evaluation of inhibition of monocarboxylate transporters in gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2011 Post-doc supervision of Bruno Costa (FCT Fellowship)
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2011 RTKs and MAPK pathway alterations in solid tumors: dissecting prognostic and therapeutic biomarkers
Orientador
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2011 Development of Computational Tools for the Integrated Analysis of DNA Microarray Data with Applications in Cancer Research
Coorientador
Bioinformatics (Doutoramento)
Universidade do Minho Departamento de Informática, Portugal
2007 - 2011 Study of New Potential Molecular Targets for Pediatric Brain Tumors Therapy
Orientador
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Study of SPINT2 methylation and correlation with MET tyrosine kinase receptor expression
Orientador
Biochemistry (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Drug encapsulation in nanostructures: Application in tumor cell lines
Orientador
Chemistry (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Influence of HOXA9 Expression in the Cellular Response to Chemotherapy
Orientador
Biochemistry (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 HOXA9's role in the response of gliomas to temozolomide and radiotherapy
Orientador
Medicine (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2010 Role of tumour suppressor gene RKIP in solid tumors
Orientador
Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2010 Evaluation of Microsatellite Instability in Brain Tumors
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Analysis of the G-174C polymorphism in the IL-6 gene in breast cancer
Orientador
Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Association of the T-1237C polymorphism in the Toll Like Receptor 9 (TLR9) gene with susceptibility to the development of breast cancer and gliomas
Orientador
Medicine (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Is the plexin B1 gene mutated in prostate cancer?
Orientador
Medicine (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Epigenetic and expression analysis of AP-2a in brain tumors
Orientador
Medicine (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2009 Establishment and characterization of two in vivo models for gliomagenesis
Orientador
Medical Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2009 Implementation of an integrative platform for gene expression data analysis
Coorientador
Bioinformatics (Mestrado)
Universidade do Minho Departamento de Informática, Portugal
2008 - 2009 Association between EGF + 61 polymorphism and risk for breast cancer
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2008 Evaluation of RKIP expression in glioblastomas
Orientador
Medicine (Curso de aperfeiçoamento / especialização)
Universidade do Minho Escola de Medicina, Portugal
2008 - 2008 Evaluation of the prognostic potential of the MGMT gene in glioblastomas at Hospital S.João
Orientador
Medicine (Curso de aperfeiçoamento / especialização)
Universidade do Minho Escola de Medicina, Portugal
2008 - 2008 Methylation study of the AP2-alpha gene in medulloblastomas
Orientador
Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2008 Role of MGMT and HOXA9 in the prognosis of glioblastomas
Orientador
Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2008 Expression of tyrosine kinase receptors PDGFRa, KIT and VEGFR-2 in gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2008 TP53 mutations in Portuguese glioblastomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2008 Evaluation of KIT mutations in GISTs
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2008 Molecular Determinants of Glioma Risk and Patient Prognosis
Orientador
Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2007 Analysis of TP53 mutations in gliomas
Orientador
Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2007 Analysis of the potential of the liquid-based cytology medium for molecular studies
Orientador
Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2007 Analysis of c-kit changes in human tumors
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2007 Optimization of PDGFRA mutations in gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2006 Study of EGFR mutations in bladder carcinomas
Orientador
Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2006 Analysis of EGFR mutations in breast cancer
Orientador
Applied Biology (Licenciatura/Bacharelato)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Analysis of molecular changes in solid tumors
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Molecular changes in glial tumors
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Influence of epigenetic changes in response to chemotherapy in patients with gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2005 Molecular Characterization of EGFRvIII and B-RAF Oncogenes in Gliomas
Orientador
Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2005 Polymorphism analysis of TP53 (codon 72) in gliomas
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2003/02 - Atual Fundamentals of medical genetics. Health Sciences (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2003/02 - Atual Genetics Medicine (Mestrado integrado) Universidade do Minho Escola de Medicina, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2011 - Atual Member of the Post-graduation committee.
Membro
Hospital de Amor, Brasil
Distinções

Prémio

2024 Merit Award
2024 Honorable Mention
2023 Best Translational Research Poster
A.C.Camargo Cancer Center, Brasil
2023 Best Poster Award- XIII Congresso Nacional
Associação Portuguesa de Neuro-Oncologia, Portugal
2022 Best Poster
XXIX Congresso de Pneumologia do Norte, Portugal
2021 Best Poster
XV Congresso da MutaGen-Brasil, Brasil
2021 Best oral presentation
Brazilian Breast Cancer Symposium, Brasil
2020 3rd Place, Oral Presentation
American Association for Cancer Research, Estados Unidos
2019 Best Oral Presentation
Sociedade Brasileira de Patologia, Brasil
2019 Best Poster
ACCamargo Cancer Center, Brasil
2019 Best Poster
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 Best Oral Presentation
Society for Neuro Oncology Latin America, Brasil
2017 Best Poster
2017 Awards SBP and EPOAHT
Sociedade Brasileira de Patologia, Brasil
2017 3rd place Prize for Best Work
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, Brasil
2017 Best Oral Presentation
Sociedade Brasileira de Patologia, Brasil
2016 50-for-50: Empowering future cancer research leaders
International Agency for Research on Cancer, França
2015 Best Poster in the field of "Mecanismos de ação de drogas"
Sociedade Brasileira de Bioquímica e Biologia Molecular, Brasil

International Union of Biochemistry and Molecular Biology, Canadá
2015 2nd place Prize for Best Oral Presentation
Hospital de Amor, Brasil
2015 Best Poster
Hospital de Amor, Brasil
2015 2nd place Prize for Best Poster
Hospital de Amor, Brasil
2015 Best article published in “Acta Urológica Portuguesa”
Sociedade Portuguesa de Neurologia, Portugal
2015 Best work of the session "Apresentação Oral / Temas Livres"
Sociedade Brasileira de Patologia, Brasil
2015 Best Poster in the field of "Bioquímica e Biologia Molecular dos Eucariotos Superiores"
Sociedade Brasileira de Bioquímica e Biologia Molecular, Brasil

International Union of Biochemistry and Molecular Biology, Canadá
2014 Award Newton Freire-Maia - in genetics and human evolution and medical genetics
2014 2nd place Prize for the Best Poster
2014 2nd place Prize for the Best Oral Presentation
Sociedade Portuguesa de Oncologia, Portugal
2014 Best Oral Presentation
Hospital de Amor, Brasil
2014 2nd place Prize for the Best Oral Presentation
Hospital de Amor, Brasil
2014 Best Poster
Hospital de Amor, Brasil
2013 Best Poster
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013 Best Oral Presentation
Hospital de Amor, Brasil
2013 Honor Mention
2012 Best Oral Presentation
2012 Travel Award
2012 “VII Prêmio Saúde Abril 2012”
2011 Best Poster in Translational Research
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2011 Merit Award
International Society of Oncology and Biomarkers, Reino Unido
2009 3rd place Prize for the Best Oral Presentation
2009 Best Poster
2009 2nd place Prize for the Best Oral Presentation in Oncology and Molecular Biology
Universidade do Porto Faculdade de Medicina, Portugal
2009 Best Poster in Oncology and Molecular Biology
Universidade do Porto Faculdade de Medicina, Portugal
2009 Best Oral Presentation
2009 Best Scientific Work
2007 1st Prize in Neurosciences
Universidade do Porto Faculdade de Medicina, Portugal
2006 1st Prize in Clinical Research
2006 1st Prize in Oncology
Universidade do Porto Faculdade de Medicina, Portugal
2006 1st Pfizer Prize in "Research in Oncology Diseases, Prof. Francisco Gentil"
2005 Best Poster
Sociedade Portuguesa de Oncologia, Portugal
1995 Highest classification in Biology at University of Porto
Fundação Engenheiro António de Almeida, Portugal