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Pedro M. P. Gois studied chemistry at the New University of Lisbon, where he obtained his Ph.D. in 2005 under the supervision of Prof. Carlos Afonso on the synthesis of biologically active heterocycles using C-H insertion reactions catalysed by di-rhodium(II) complexes. From May 2005 to May 2008 he worked as a postdoctoral research fellow at the University of Sussex with Prof. F. Geoffrey N. Cloke FRS, at the University College of London with Prof. Stephen Caddick and at the Instituto Superior Técnico (Technical University of Lisbon) with Prof. Carlos Afonso on the discovery of new C-C bond formation reactions catalysed by NHC palladium complexes. In May 2008, he joined the Faculty of Pharmacy of the University of Lisbon (FFUL) as a research assistant in the medicinal chemistry group (iMed.ULisboa - Research Institute for Medicines), and in July 2013, Gois was appointed principal investigator at the same institution and head of the bioorganic group, whose mission was to develop bio-inspired synthetic methods. In 2017, he obtained his habilitation in pharmacy and was appointed assistant professor at the Faculty of Pharmacy. He holds now, the position of associate professor with habilitation at the FFUL and is a member of various governing bodies of the institution, such as the School and Scientific Councils, and is part of the Executive Commission of iMed.ULisboa. Currently, Gois heads the Chemical Biology Laboratory at iMed.ULisboa, which research programme focuses on the design of functional molecules that can be used to control biological processes and biomaterials.
Identificação

Identificação pessoal

Nome completo
Pedro Miguel Pimenta Gois

Nomes de citação

  • Gois, Pedro
  • Gois PMP

Identificadores de autor

Ciência ID
AD1B-6A14-C952
ORCID iD
0000-0002-7698-630X
Researcher Id
A-9251-2014
Scopus Author Id
6507726637

Domínios de atuação

  • Ciências Exatas - Química - Química Orgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2016/08/10
Concluído
Agregação em Farmácia (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Agregação em Farmácia" (TESE/DISSERTAÇÃO)
Aprovado por Unanimidade
2005/05/03 - 2008/04/01
Concluído
Pos-Doc (Pós-doutoramento)
Especialização em Catalysis
university college of london Chemistry Detarment, Reino Unido

University of Sussex Department of Chemistry and Biochemistry, Reino Unido

Universidade de Lisboa Instituto Superior Técnico, Portugal
2005
Concluído
Quimica Orgânica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Studies on the di-rhodium (II) catalysed cyclisation of 2-diazo-2-dietoxyphosphoryl-acetamidas" (TESE/DISSERTAÇÃO)
Aproved by Unanimity
2005
Concluído
Química (Doutoramento)
Especialização em Especialidade: Química Orgânica
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Estudo Sobre a Ciclização de 2-diazo2dietoxifosforil-acetamidas Catalizada por Catalizadores de Di-ródio (ii)" (TESE/DISSERTAÇÃO)
2000/09/07
Concluído
Química Aplicada (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
16 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2008/05/02 - 2013/07/02 Investigador Contratado (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2023/06/01 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2020/01/17 - Atual Executive Board member of iMed.Ulisboa Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2020/01/01 - Atual Head of the Chemical Biology Laboratory at iMed.ULisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2019/01/01 - Atual Member of the School Council Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/01/01 - Atual Member of the Scientific Council Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/01/01 - 2019/12/01 Head of the Bioorganic Group of iMed.Ulisboa Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2017/02/01 - Atual Assistant Professor with Habilitation Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/07/02 - 2017 Principal investigator FCT Investigator - Development grant Universidade de Lisboa Faculdade de Farmácia, Portugal
1999/06/01 - 1999/09/01 Pratical Course on the “Investigation of Grignard raction and by-products” Universitetet i Bergen Kjemisk institutt, Noruega
1998/02/01 - 1998/07/30 Laboratory assistant of the Química II discipline Universidade Nova de Lisboa Departamento de Química, Portugal
Projetos

Bolsa

Designação Financiadores
2022/01/17 - 2025/01/17 SmartBox: Engineering the first generation of ROS responsive ADCs
PTDC/QUI-OUT/3989/2021
Investigador responsável
FARM-ID, Associção da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARMID) , Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Em curso

Projeto

Designação Financiadores
2021/03/01 - Atual 1Pot2Cat: One-pot bimetallic catalyzed synthesis of challenging N-heterocycles
Co-Investigador Responsável (Co-IR)
FARM-ID, Associção da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARMID) , Portugal
Em curso
Produções

Publicações

Artigo em revista
  1. Silva, Maria J. S. A.; Zhang, Yiyi; Vinck, Robin; Santos, Fábio M. F.; António, João P. M.; Gourdon-Grünewaldt, Lisa; Zaouter, Charlotte; et al. "BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation". Bioconjugate Chemistry 34 12 (2023): 2337-2344. http://dx.doi.org/10.1021/acs.bioconjchem.3c00449.
    10.1021/acs.bioconjchem.3c00449
  2. Padanha, Rita; Cavadas, Rafaela A. N.; Merino, Pedro; António, João P. M.; Gois, Pedro M. P.. "N-Terminal Cysteine Bioconjugation with (2-Cyanamidophenyl)boronic Acids Enables the Direct Formation of Benzodiazaborines on Peptides". Organic Letters 25 29 (2023): 5476-5480. http://dx.doi.org/10.1021/acs.orglett.3c01835.
    10.1021/acs.orglett.3c01835
  3. Gois, Pedro M. P.; António, João P. M.; Monteiro, Sofia A. G.. "Boronic Acids and Beyond: ROS-Responsive Prodrugs as Tools for a Safer and More Effective Cancer Chemotherapy". Synlett 34 18 (2023): 2129-2158. http://dx.doi.org/10.1055/a-2132-1356.
    10.1055/a-2132-1356
  4. Matos, Ana I.; Peres, Carina; Carreira, Barbara; Moura, Liane I. F.; Acúrcio, Rita C.; Vogel, Theresa; Wegener, Erik; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science 10 25 (2023): http://dx.doi.org/10.1002/advs.202300299.
    10.1002/advs.202300299
  5. Felicidade, João; Santos, Fabio M. F.; Arteaga, Jesús F.; Remón, Patricia; Campos-González, René; Nguyen, Ha-Chi; Nájera, Francisco; et al. "Engineering the BASHY Dye Platform toward Architectures with Responsive Fluorescence". Chemistry – A European Journal 29 31 (2023): http://dx.doi.org/10.1002/chem.202300579.
    10.1002/chem.202300579
  6. André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra; Nogueira, Sara; Bule, Pedro; Carvalho, Joana Inês; António, João P. M.; et al. "Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-31568-x.
    10.1038/s41598-023-31568-x
  7. Silva, Maria J. S. A.; Cavadas, Rafaela A. N.; Faustino, Hélio; Veiros, Luís F.; Gois, Pedro M. P.. "Interactive Bioconjugation at N -Terminal Cysteines by Using O -Salicylaldehyde Esters towards Dual Site-Selective Functionalization". Chemistry – A European Journal 28 67 (2022): http://dx.doi.org/10.1002/chem.202202377.
    10.1002/chem.202202377
  8. Afonso, Cláudia F.; Marques, Marta C.; António, João P. M.; Cordeiro, Carlos; Gois, Pedro M. P.; Cal, Pedro M. S. D.; Bernardes, Gonçalo J. L.. "Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones". Angewandte Chemie International Edition 61 46 (2022): http://dx.doi.org/10.1002/anie.202208543.
    10.1002/anie.202208543
  9. Mariama Djaló; Maria J. S. A. Silva; Hélio Faustino; Sandra N. Pinto; Ricardo Mendonça; Pedro M. P. Gois. "Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues". Chemical Communications 58 (2022): 7928-7931.
    10.1039/d2cc02204d
  10. Poeira, Diogo L.; Negrão, Ana Cláudia R.; Faustino, Hélio; Coelho, Jaime A. S.; Gomes, Clara S. B.; Gois, Pedro M. P.; Marques, M. Manuel B.. "Hypervalent Iodine(III) Reagents with Transferable Primary Amines: Structure and Reactivity on the Electrophilic a-Amination of Stabilized Enolates". Organic Letters 24 2 (2022): 776-781. http://dx.doi.org/10.1021/acs.orglett.1c04312.
    10.1021/acs.orglett.1c04312
  11. Baldo, Silvia; Antunes, Patrícia; Felicidade, João Falcão; Santos, Fábio M. F.; Arteaga, Jesús F.; Fernandes, Fábio; Pischel, Uwe; Pinto, Sandra N.; Gois, Pedro M. P.. "The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib–GV1001 Conjugate". ACS Medicinal Chemistry Letters 13 1 (2021): 128-133. http://dx.doi.org/10.1021/acsmedchemlett.1c00615.
    10.1021/acsmedchemlett.1c00615
  12. Pinto, Maria V.; Santos, Fábio M. F.; Barros, Catarina; Ribeiro, Ana Rita; Pischel, Uwe; Gois, Pedro M. P.; Fernandes, Adelaide. "BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination". Cells 10 11 (2021): 3163. http://dx.doi.org/10.3390/cells10113163.
    10.3390/cells10113163
  13. António, João P. M.; Carvalho, Joana Inês; André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Faustino, Hélio; Lopes, Ricardo M. R. M.; et al. "Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates". Angewandte Chemie International Edition 60 49 (2021): 25914-25921. http://dx.doi.org/10.1002/anie.202109835.
    10.1002/anie.202109835
  14. Zegota, Maksymilian Marek; Müller, Michael Andreas; Lantzberg, Bellinda; Kizilsavas, Gönül; Coelho, Jaime A. S.; Moscariello, Pierpaolo; Martínez-Negro, María; et al. "Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments". Journal of the American Chemical Society 143 41 (2021): 17047-17058. http://dx.doi.org/10.1021/jacs.1c06559.
    10.1021/jacs.1c06559
  15. Lopes, Raquel R.; Tomé, Catarina S.; Russo, Roberto; Paterna, Roberta; Leandro, João; Candeias, Nuno R.; Gonçalves, Lídia M. D.; et al. "Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives". Biomolecules 11 3 (2021): 462. http://dx.doi.org/10.3390/biom11030462.
    10.3390/biom11030462
  16. Silva, Maria J. S. A.; Gois, Pedro M. P.; Gasser, Gilles. "Unveiling the Potential of Transition Metal Complexes for Medicine: Translational in Situ Activation of Metal-Based Drugs from Bench to in Vivo Applications". ChemBioChem 22 10 (2021): 1740-1742. http://dx.doi.org/10.1002/cbic.202100015.
    10.1002/cbic.202100015
  17. José, Maria; Faustino, Hélio; Coelho, Jaime; Vaz Pinto, Maria; Fernandes, Adelaide; companon, ismael; Corzana, Francisco; et al. "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angewandte Chemie International Edition (2021): http://dx.doi.org/10.1002/anie.202016936.
    10.1002/anie.202016936
  18. António, João P. M.; Faustino, Hélio; Gois, Pedro M. P.. "A 2-formylphenylboronic acid (2FPBA)-maleimide crosslinker: a versatile platform for Cys-peptide–hydrazine conjugation and interplay". Organic & Biomolecular Chemistry 19 28 (2021): 6221-6226. http://dx.doi.org/10.1039/d1ob00917f.
    10.1039/d1ob00917f
  19. Xu, Lujuan; Silva, Maria J. S. A.; Gois, Pedro M. P.; Kuan, Seah Ling; Weil, Tanja. "Chemoselective cysteine or disulfide modification via single atom substitution in chloromethyl acryl reagents". Chemical Science 12 40 (2021): 13321-13330. http://dx.doi.org/10.1039/d1sc03250j.
    10.1039/d1sc03250j
  20. Paterna, Roberta; Padanha, Rita; Russo, Roberto; Frade, Raquel F.M.; Faustino, Hélio; Gois, Pedro M.P.. "Synthesis of 4-substituted-3-Hydroxyquinolin-2(1H)-ones with anticancer activity". Tetrahedron 76 51 (2020): 130983. http://dx.doi.org/10.1016/j.tet.2020.130983.
    10.1016/j.tet.2020.130983
  21. Russo, Roberto; Padanha, Rita; Fernandes, Fábio; Veiros, Luis F.; Corzana, Francisco; Gois, Pedro M. P.. "Engineering Boron Hot Spots for the Site-Selective Installation of Iminoboronates on Peptide Chains". Chemistry – A European Journal 26 66 (2020): 15226-15231. http://dx.doi.org/10.1002/chem.202002675.
    10.1002/chem.202002675
  22. Santos, Fábio M. F.; Domínguez, Zoe; Fernandes, João P. L.; Parente Carvalho, Cátia; Collado, Daniel; Pérez-Inestrosa, Ezequiel; Pinto, Maria V.; et al. "Cyanine-Like Boronic Acid-Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications". Chemistry – A European Journal 26 62 (2020): 14064-14069. http://dx.doi.org/10.1002/chem.202001623.
    10.1002/chem.202001623
  23. Lozano, Ana; Pamplona, Beatriz; Kilich, Tymon; Labuda, Marta; Mendes, Mónica; Pereira-da-Silva, João; García, Gustavo; et al. "The Role of Electron Transfer in the Fragmentation of Phenyl and Cyclohexyl Boronic Acids". International Journal of Molecular Sciences 20 22 (2019): 5578. http://dx.doi.org/10.3390/ijms20225578.
    10.3390/ijms20225578
  24. Hebel, Marco; Riegger, Andreas; Zegota, Maksymilian M.; Kizilsavas, Gönül; Gacanin, Jasmina; Pieszka, Michaela; Lückerath, Thorsten; et al. "Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes". Journal of the American Chemical Society 141 36 (2019): 14026-14031. http://dx.doi.org/10.1021/jacs.9b03107.
    Publicado • 10.1021/jacs.9b03107
  25. Conniot, João; Scomparin, Anna; Peres, Carina; Yeini, Eilam; Pozzi, Sabina; Matos, Ana I.; Kleiner, Ron; et al. "Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators". Nature Nanotechnology 14 9 (2019): 891-901. http://dx.doi.org/10.1038/s41565-019-0512-0.
    10.1038/s41565-019-0512-0
  26. Poeira, Diogo L.; Macara, João; Faustino, Hélio; Coelho, Jaime A. S.; Gois, Pedro M. P.; Marques, M. Manuel B.. "Hypervalent Iodine Mediated Sulfonamide Synthesis". European Journal of Organic Chemistry 2019 15 (2019): 2695-2701. http://dx.doi.org/10.1002/ejoc.201900259.
    10.1002/ejoc.201900259
  27. António, João P. M.; Russo, Roberto; Carvalho, Cátia Parente; Cal, Pedro M. S. D.; Gois, Pedro M. P.. "Boronic acids as building blocks for the construction of therapeutically useful bioconjugates". Chemical Society Reviews 48 13 (2019): 3513-3536. http://dx.doi.org/10.1039/c9cs00184k.
    10.1039/c9cs00184k
  28. Ravasco, João M. J. M.; Faustino, Hélio; Trindade, Alexandre; Gois, Pedro M. P.. "Bioconjugation with Maleimides: A Useful Tool for Chemical Biology". Chemistry – A European Journal 25 1 (2018): 43-59. http://dx.doi.org/10.1002/chem.201803174.
    10.1002/chem.201803174
  29. Jiménez, Vicente G.; Santos, Fábio M. F.; Castro-Fernández, Silvia; Cuerva, Juan M.; Gois, Pedro M. P.; Pischel, Uwe; Campaña, Araceli G.. "Circularly Polarized Luminescence of Boronic Acid-Derived Salicylidenehydrazone Complexes Containing Chiral Boron as Stereogenic Unit". The Journal of Organic Chemistry 83 22 (2018): 14057-14062. http://dx.doi.org/10.1021/acs.joc.8b01844.
    10.1021/acs.joc.8b01844
  30. Santos, Fábio M. F.; Domínguez, Zoe; Alcaide, María M.; Matos, Ana I.; Florindo, Helena F.; Candeias, Nuno R.; Gois, Pedro M. P.; Pischel, Uwe. "Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes". ChemPhotoChem 2 12 (2018): 1038-1045. http://dx.doi.org/10.1002/cptc.201800150.
    10.1002/cptc.201800150
  31. Lopes, Ricardo M. R. M.; Ventura, Ana E.; Silva, Liana C.; Faustino, Hélio; Gois, Pedro M. P.. "N,O -Iminoboronates: Reversible Iminoboronates with Improved Stability for Cancer Cells Targeted Delivery". Chemistry - A European Journal 24 48 (2018): 12495-12499. http://dx.doi.org/10.1002/chem.201802515.
    10.1002/chem.201802515
  32. António, João P. M.; Gonçalves, Lídia M.; Guedes, Rita C.; Moreira, Rui; Gois, Pedro M. P.. "Diazaborines as New Inhibitors of Human Neutrophil Elastase". ACS Omega 3 7 (2018): 7418-7423. http://dx.doi.org/10.1021/acsomega.8b00702.
    10.1021/acsomega.8b00702
  33. Alcaide, María M.; Santos, Fabio M. F.; Pais, Vânia F.; Carvalho, Joana Inês; Collado, Daniel; Pérez-Inestrosa, Ezequiel; Arteaga, Jesús F.; et al. "Electronic and Functional Scope of Boronic Acid Derived Salicylidenehydrazone (BASHY) Complexes as Fluorescent Dyes". The Journal of Organic Chemistry 82 14 (2017): 7151-7158. http://dx.doi.org/10.1021/acs.joc.7b00601.
    10.1021/acs.joc.7b00601
  34. Cal, Pedro M. S. D.; Sieglitz, Florian; Santos, Fábio M. F.; Parente Carvalho, Cátia; Guerreiro, Ana; Bertoldo, Jean B.; Pischel, Uwe; Gois, Pedro M. P.; Bernardes, Gonçalo J. L.. "Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells". Chemical Communications 53 2 (2017): 368-371. http://dx.doi.org/10.1039/c6cc08671c.
    10.1039/c6cc08671c
  35. Santos, F.M.F.; Matos, A.I.; Ventura, A.E.; Gonçalves, J.; Veiros, L.F.; Florindo, H.F.; Gois, P.M.P.; et al. "Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates". Angewandte Chemie - International Edition 56 32 (2017): 9346-9350. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022198030&partnerID=MN8TOARS.
    10.1002/anie.201703492
  36. Nunes, Mário A.P.; Gois, Pedro M.P.; Rosa, M. Emilia; Martins, Samuel; Fernandes, Pedro C.B.; Ribeiro, Maria H.L.. "Boronic acids as efficient cross linkers for PVA: synthesis and application of tunable hollow microspheres in biocatalysis". Tetrahedron 72 46 (2016): 7293-7305. http://dx.doi.org/10.1016/j.tet.2016.02.017.
    10.1016/j.tet.2016.02.017
  37. Nunes, Mário A.P.; Martins, Samuel; Rosa, M. Emilia; Gois, Pedro M.P.; Fernandes, Pedro C.B.; Ribeiro, Maria H.L.. "Improved thermostable polyvinyl alcohol electrospun nanofibers with entangled naringinase used in a novel mini-packed bed reactor". Bioresource Technology 213 (2016): 208-215. http://dx.doi.org/10.1016/j.biortech.2016.03.058.
    10.1016/j.biortech.2016.03.058
  38. Candeias, Nuno R.; Paterna, Roberta; Gois, Pedro M. P.. "Homologation Reaction of Ketones with Diazo Compounds". Chemical Reviews 116 5 (2016): 2937-2981. http://dx.doi.org/10.1021/acs.chemrev.5b00381.
    10.1021/acs.chemrev.5b00381
  39. Faustino, Hélio; Silva, Maria J. S. A.; Veiros, Luís F.; Bernardes, Gonçalo J. L.; Gois, Pedro M. P.. "Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation". Chemical Science 7 8 (2016): 5052-5058. http://dx.doi.org/10.1039/c6sc01520d.
    10.1039/c6sc01520d
  40. Akkapeddi, Padma; Azizi, Saara-Anne; Freedy, Allyson M.; Cal, Pedro M. S. D.; Gois, Pedro M. P.; Bernardes, Gonçalo J. L.. "Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry". Chemical Science 7 5 (2016): 2954-2963. http://dx.doi.org/10.1039/c6sc00170j.
    10.1039/c6sc00170j
  41. Cal, P.M.S.D.; Frade, R.F.M.; Cordeiro, C.; Gois, P.M.P.. "Corrigendum to: Reversible Lysine Modification on Proteins by Using Functionalized Boronic Acids (Chem. Eur. J., (2015), 21, (8182-8187), 10.1002/chem.201500127)". Chemistry - A European Journal 22 47 (2016): 16711-16711. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994424448&partnerID=MN8TOARS.
    10.1002/chem.201503646
  42. Santos, Fábio M. F.; Rosa, João N.; Candeias, Nuno R.; Carvalho, Cátia Parente; Matos, Ana I.; Ventura, Ana E.; Florindo, Helena F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal 22 5 (2015): 1537-1537. http://dx.doi.org/10.1002/chem.201504919.
    10.1002/chem.201504919
  43. Cal, Pedro M. S. D.; Frade, Raquel F. M.; Cordeiro, Carlos; Gois, Pedro M. P.. "Reversible Lysine Modification on Proteins by Using Functionalized Boronic Acids". Chemistry - A European Journal 21 22 (2015): 8182-8187. http://dx.doi.org/10.1002/chem.201500127.
    10.1002/chem.201500127
  44. Lombard, Fanny J.; Coster, Mark J.. "Rhodium(ii)-catalysed intramolecular C–H insertion a- to oxygen: reactivity, selectivity and applications to natural product synthesis". Organic & Biomolecular Chemistry 13 23 (2015): 6419-6431. http://dx.doi.org/10.1039/c5ob00311c.
    10.1039/c5ob00311c
  45. Rosholm, Tomi; Gois, Pedro M. P.; Franzen, Robert; Candeias, Nuno R.. "Glycerol as an Efficient Medium for the Petasis Borono-Mannich Reaction". ChemistryOpen 4 1 (2014): 39-46. http://dx.doi.org/10.1002/open.201402066.
    10.1002/open.201402066
  46. Cal, Pedro M. S. D.; Bernardes, Gonçalo J. L.; Gois, Pedro M. P.. "Cysteine-Selective Reactions for Antibody Conjugation". Angewandte Chemie International Edition 53 40 (2014): 10585-10587. http://dx.doi.org/10.1002/anie.201405702.
    10.1002/anie.201405702
  47. Almeida, Ana R.; Dias, Roberto D.; Monteiro, Carlos J. P.; Abreu, Artur R.; Gois, Pedro M. P.; Bayon, J. Carles; Pereira, Mariette M.. "Rhodium-Catalysed Tandem Hydroformylation/Arylation Reaction with Boronic Acids". Advanced Synthesis & Catalysis 356 6 (2014): 1223-1228. http://dx.doi.org/10.1002/adsc.201300968.
    10.1002/adsc.201300968
  48. Montalbano, Francesco; Leandro, João; Farias, Gonçalo D. V. F.; Lino, Paulo R.; Guedes, Rita C.; Vicente, João B.; Leandro, Paula; Gois, Pedro M. P.. "Phenylalanine iminoboronates as new phenylalanine hydroxylase modulators". RSC Adv. 4 105 (2014): 61022-61027. http://dx.doi.org/10.1039/c4ra10306h.
    10.1039/c4ra10306h
  49. António, João P. M.; Frade, Raquel F. M.; Santos, Fábio M. F.; Coelho, Jaime A. S.; Afonso, Carlos A. M.; Gois, Pedro M. P.; Trindade, Alexandre F.. "NHC catalysed direct addition of HMF to diazo compounds: synthesis of acyl hydrazones with antitumor activity". RSC Adv. 4 55 (2014): 29352-29356. http://dx.doi.org/10.1039/c4ra03710c.
    10.1039/c4ra03710c
  50. Cal, Pedro M. S. D.; Frade, Raquel F. M.; Chudasama, Vijay; Cordeiro, Carlos; Caddick, Stephen; Gois, Pedro M. P.. "Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates". Chem. Commun. 50 40 (2014): 5261-5263. http://dx.doi.org/10.1039/c3cc47534d.
    10.1039/c3cc47534d
  51. Paterna, Roberta; André, Vânia; Duarte, M. Teresa; Veiros, Luis F.; Candeias, Nuno R.; Gois, Pedro M. P.. "Ring-Expansion Reaction of Isatins with Ethyl Diazoacetate Catalyzed by Dirhodium(II)/DBU Metal-Organic System: En Route to Viridicatin Alkaloids". European Journal of Organic Chemistry 2013 28 (2013): 6280-6290. http://dx.doi.org/10.1002/ejoc.201300796.
    10.1002/ejoc.201300796
  52. Santos, Fábio M. F.; Rosa, João N.; André, Vânia; Duarte, M. Teresa; Veiros, Luís F.; Gois, Pedro M. P.. "N-Heterocyclic Carbene Catalyzed Addition of Aldehydes to Diazo Compounds: Stereoselective Synthesis of N-Acylhydrazones". Organic Letters 15 7 (2013): 1760-1763. http://dx.doi.org/10.1021/ol400563w.
    10.1021/ol400563w
  53. Coelho, Jaime A. S.; Trindade, Alexandre F.; Wanke, Riccardo; Rocha, Bruno G. M.; Veiros, Luis F.; Gois, Pedro M. P.; Pombeiro, Armando J. L.; Afonso, Carlos A. M.. "N-Heterocyclic Carbene Dirhodium(II) Complexes as Catalysts for Allylic and Benzylic Oxidations". European Journal of Organic Chemistry 2013 8 (2013): 1471-1478. http://dx.doi.org/10.1002/ejoc.201201300.
    10.1002/ejoc.201201300
  54. Montalbano, Francesco; Cal, Pedro M. S. D.; Carvalho, Marta A. B. R.; Gonçalves, Lídia M.; Lucas, Susana D.; Guedes, Rita C.; Veiros, Luís F.; Moreira, Rui; Gois, Pedro M. P.. "Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction". Organic & Biomolecular Chemistry 11 27 (2013): 4465. http://dx.doi.org/10.1039/c3ob40614h.
    10.1039/c3ob40614h
  55. Candeias, Nuno R.; Carias, Carolina; Gomes, Luis F. R.; André, Vânia; Duarte, M. Teresa; Gois, Pedro M. P.; Afonso, Carlos A. M.. "Asymmetric Intramolecular C-H Insertion of a-Diazoacetamides in Water by Dirhodium(II) Catalysts Derived from Natural Amino Acids". Advanced Synthesis & Catalysis 354 16 (2012): 2921-2927. http://dx.doi.org/10.1002/adsc.201200101.
    10.1002/adsc.201200101
  56. Cal, Pedro M. S. D.; Vicente, João B.; Pires, Elisabete; Coelho, Ana V.; Veiros, Lui´s F.; Cordeiro, Carlos; Gois, Pedro M. P.. "Iminoboronates: A New Strategy for Reversible Protein Modification". Journal of the American Chemical Society 134 24 (2012): 10299-10305. http://dx.doi.org/10.1021/ja303436y.
    10.1021/ja303436y
  57. Candeias, Nuno R.; Paterna, Roberta; Cal, Pedro M. S. D.; Góis, Pedro M. P.. "A Sustainable Protocol for the Aqueous Multicomponent Petasis Borono–Mannich Reaction". Journal of Chemical Education 89 6 (2012): 799-802. http://dx.doi.org/10.1021/ed200509q.
    10.1021/ed200509q
  58. Trindade, Alexandre F.; Coelho, Jaime A. S.; Afonso, Carlos A. M.; Veiros, Luis F.; Gois, Pedro M. P.. "Fine Tuning of Dirhodium(II) Complexes: Exploring the Axial Modification". ACS Catalysis 2 3 (2012): 370-383. http://dx.doi.org/10.1021/cs200597a.
    10.1021/cs200597a
  59. Montalbano, Francesco; Candeias, Nuno R.; Veiros, Luís F.; André, Vânia; Duarte, M. Teresa; Bronze, Maria R.; Moreira, Rui; Gois, Pedro M. P.. "Four-Component Assembly of Chiral N–B Heterocycles with a Natural Product-Like Framework". Organic Letters 14 4 (2012): 988-991. http://dx.doi.org/10.1021/ol203224n.
    10.1021/ol203224n
  60. Candeias, Nuno R.; Afonso, Carlos A. M.; Gois, Pedro M. P.. "Making expensive dirhodium(ii) catalysts cheaper: Rh(ii) recycling methods". Organic & Biomolecular Chemistry 10 17 (2012): 3357. http://dx.doi.org/10.1039/c2ob06731e.
    10.1039/c2ob06731e
  61. Zakrzewska, M.E.; Cal, P.M.S.D.; Candeias, N.R.; Bogel-Lukasik, R.; Afonso, C.A.M.; Ponte, M.N.; Gois, P.M.P.. "Intramolecular C-H insertion catalyzed by dirhodium(II) complexes using CO2as the reaction media". Green Chemistry Letters and Reviews 5 2 (2012): 211-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859505886&partnerID=MN8TOARS.
    10.1080/17518253.2011.620009
  62. R. Almeida, Ana; F. Peixoto, Andreia; J. F. Calvete, Mario; M. P. Gois, Pedro; M. Pereira, Mariette. "Rhodium(I) N-Heterocyclic Carbene Complexes as Catalysts for Hydroformylation of Olefins: An Overview". Current Organic Synthesis 8 5 (2011): 764-775. http://dx.doi.org/10.2174/157017911796957339.
    10.2174/157017911796957339
  63. Vila-Real, Helder; Alfaia, António J.; Rosa, João N.; Gois, Pedro M.P.; Rosa, M. Emilia; Calado, António R.T.; Ribeiro, Maria H.. "a-Rhamnosidase and ß-glucosidase expressed by naringinase immobilized on new ionic liquid sol–gel matrices: Activity and stability studies". Journal of Biotechnology 152 4 (2011): 147-158. http://dx.doi.org/10.1016/j.jbiotec.2010.08.005.
    10.1016/j.jbiotec.2010.08.005
  64. Reddy, R. Sudarshan; Rosa, João N.; Veiros, Luís F.; Caddick, Stephen; Gois, Pedro M. P.. "NHC/Iron cooperative catalysis: aerobic oxidative esterification of aldehydes with phenols". Organic & Biomolecular Chemistry 9 9 (2011): 3126. http://dx.doi.org/10.1039/c1ob05151b.
    10.1039/c1ob05151b
  65. Candeias, Nuno R.; Montalbano, Francesco; Cal, Pedro M. S. D.; Gois, Pedro M. P.. "Boronic Acids and Esters in the Petasis-Borono Mannich Multicomponent Reaction". Chemical Reviews 110 10 (2010): 6169-6193. http://dx.doi.org/10.1021/cr100108k.
    10.1021/cr100108k
  66. Trindade, Alexandre F.; André, Vânia; Duarte, M. Teresa; Veiros, Luís F.; Gois, Pedro M.P.; Afonso, Carlos A.M.. "Selective arylation of aldehydes with di-rhodium(II)/NHC catalysts". Tetrahedron 66 44 (2010): 8494-8502. http://dx.doi.org/10.1016/j.tet.2010.08.050.
    10.1016/j.tet.2010.08.050
  67. Rosa, Joa~o N.; Reddy, R. Sudarshan; Candeias, Nuno R.; Cal, Pedro M. S. D.; Gois, Pedro M. P.. "NHC-Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids". Organic Letters 12 12 (2010): 2686-2689. http://dx.doi.org/10.1021/ol100302e.
    10.1021/ol100302e
  68. Frade, Raquel F.M.; Candeias, Nuno R.; Duarte, Catarina M.M.; André, Vânia; Teresa Duarte, M.; Gois, Pedro M.P.; Afonso, Carlos A.M.. "New dirhodium complex with activity towards colorectal cancer". Bioorganic & Medicinal Chemistry Letters 20 11 (2010): 3413-3415. http://dx.doi.org/10.1016/j.bmcl.2010.04.002.
    10.1016/j.bmcl.2010.04.002
  69. Candeias, Nuno R.; Cal, Pedro M.S.D.; André, Vânia; Duarte, M. Teresa; Veiros, Luís F.; Gois, Pedro M.P.. "Water as the reaction medium for multicomponent reactions based on boronic acids". Tetrahedron 66 14 (2010): 2736-2745. http://dx.doi.org/10.1016/j.tet.2010.01.084.
    10.1016/j.tet.2010.01.084
  70. Afonso, Carlos; Gomes, Luis; Trindade, Alexandre; Candeias, Nuno; Veiros, Luís; Gois, Pedro. "Cyclization of Diazoacetamides Catalyzed by N-Heterocyclic Carbene Dirhodium(II) Complexes". Synthesis 2009 20 (2009): 3519-3526. http://dx.doi.org/10.1055/s-0029-1217005.
    10.1055/s-0029-1217005
  71. Candeias, Nuno R.; Branco, Luís C.; Gois, Pedro M. P.; Afonso, Carlos A. M.; Trindade, Alexandre F.. "More Sustainable Approaches for the Synthesis of N-Based Heterocycles". Chemical Reviews 109 6 (2009): 2703-2802. http://dx.doi.org/10.1021/cr800462w.
    10.1021/cr800462w
  72. Candeias, Nuno R.; Veiros, Luís F.; Afonso, Carlos A. M.; Gois, Pedro M. P.. "Water: A Suitable Medium for the Petasis Borono-Mannich Reaction". European Journal of Organic Chemistry 2009 12 (2009): 1859-1863. http://dx.doi.org/10.1002/ejoc.200900056.
    10.1002/ejoc.200900056
  73. Esposito, Oriana; Gois, Pedro M. P.; de K. Lewis, Alexandra K.; Caddick, Stephen; Cloke, F. Geoffrey N.; Hitchcock, Peter B.. "Alkylpalladium N-Heterocyclic Carbene Complexes: Synthesis, Reactivity, and Catalytic Properties". Organometallics 27 24 (2008): 6411-6418. http://dx.doi.org/10.1021/om800455h.
    10.1021/om800455h
  74. Gomes, Luis F.R.; Trindade, Alexandre F.; Candeias, Nuno R.; Gois, Pedro M.P.; Afonso, Carlos A.M.. "Intramolecular C–H insertion using NHC–di-rhodium(II) complexes: the influence of axial coordination". Tetrahedron Letters 49 52 (2008): 7372-7375. http://dx.doi.org/10.1016/j.tetlet.2008.10.054.
    10.1016/j.tetlet.2008.10.054
  75. Candeias, Nuno R.; Gois, Pedro M. P.; Veiros, Luis F.; Afonso, Carlos A. M.. "C-H Carbene Insertion of a-Diazo Acetamides by Photolysis in Non-Conventional Media". The Journal of Organic Chemistry 73 15 (2008): 5926-5932. http://dx.doi.org/10.1021/jo800980c.
    10.1021/jo800980c
  76. Trindade, Alexandre F.; Gois, Pedro M. P.; Veiros, Lui´s F.; Andre´, Va^nia; Duarte, M. Teresa; Afonso, Carlos A. M.; Caddick, Stephen; Cloke, F. Geoffrey N.. "Axial Coordination of NHC Ligands on Dirhodium(II) Complexes: Generation of a New Family of Catalysts". The Journal of Organic Chemistry 73 11 (2008): 4076-4086. http://dx.doi.org/10.1021/jo800087n.
    10.1021/jo800087n
  77. Gois, Pedro M. P.; Trindade, Alexandre F.; Veiros, Luís F.; André, Vania; Duarte, M. Teresa; Afonso, Carlos A. M.; Caddick, Stephen; Cloke, F. Geoffrey N.. "Tuning the Reactivity of Dirhodium(II) Complexes with Axial N-Heterocyclic Carbene Ligands: The Arylation of Aldehydes". Angewandte Chemie 119 30 (2007): 5852-5855. http://dx.doi.org/10.1002/ange.200700924.
    10.1002/ange.200700924
  78. Afonso, Carlos A. M.; Branco, Luís C.; Candeias, Nuno R.; Gois, Pedro M. P.; Lourenço, Nuno M. T.; Mateus, Nuno M. M.; Rosa, João N.. "Efficient catalyst reuse by simple dissolution in non-conventional media". Chem. Commun. 26 (2007): 2669-2679. http://dx.doi.org/10.1039/b607483a.
    10.1039/b607483a
  79. Candeias, Nuno R.; Gois, Pedro M. P.; Afonso, Carlos A. M.. "Rh(II)-Catalyzed Intramolecular C-H Insertion of Diazo Substrates in Water:  Scope and Limitations". The Journal of Organic Chemistry 71 15 (2006): 5489-5497. http://dx.doi.org/10.1021/jo060397a.
    10.1021/jo060397a
  80. Branco, Luís C.; Gois, Pedro M. P.; Lourenço, Nuno M. T.; Kurteva, Vanya B.; Afonso, Carlos A. M.. "Simple transformation of crystalline chiral natural anions to liquid medium and their use to induce chirality". Chem. Commun. 22 (2006): 2371-2372. http://dx.doi.org/10.1039/b600816j.
    10.1039/b600816j
  81. P. Gois, Pedro M.; Candeias, Nuno R.; Afonso, Carlos A.M.. "Preparation of enantioselective enriched a-(dialkoxyphosphoryl)lactams via intramolecular CH insertion with chiral dirhodium(II) catalysts". Journal of Molecular Catalysis A: Chemical 227 1-2 (2005): 17-24. http://dx.doi.org/10.1016/j.molcata.2004.09.041.
    10.1016/j.molcata.2004.09.041
  82. Candeias, Nuno R.; Gois, Pedro M. P.; Afonso, Carlos A. M.. "Rh(ii) catalysed intramolecular C–H insertion of diazo substrates in water: a simple and efficient approach to catalyst reuse". Chem. Commun. 3 (2005): 391-393. http://dx.doi.org/10.1039/b414233k.
    10.1039/b414233k
  83. Gois, Pedro M. P.; Afonso, Carlos A. M.. "Stereo- and Regiocontrol in the Formation of Lactams by Rhodium-Carbenoid C-H Insertion ofa-Diazoacetamides". European Journal of Organic Chemistry 2004 18 (2004): 3773-3788. http://dx.doi.org/10.1002/ejoc.200400237.
    10.1002/ejoc.200400237
  84. Gois, Pedro M. P.; Afonso, Carlos A. M.. "Dirhodium(II)-Catalyzed C—H Insertion on a-Diazo-a-phosphono-acetamides in an Ionic Liquid.". ChemInform 34 48 (2003): http://dx.doi.org/10.1002/chin.200348148.
    10.1002/chin.200348148
  85. Gois, Pedro M. P.; Afonso, Carlos A. M.. "Regio- and Stereoselective Dirhodium(II)-Catalysed Intramolecular C-H Insertion Reactions ofa-Diazo-a-(dialkoxyphosphoryl)acetamides and -acetates". European Journal of Organic Chemistry 2003 19 (2003): 3798-3810. http://dx.doi.org/10.1002/ejoc.200300330.
    10.1002/ejoc.200300330
  86. Norton Matos, Marta R. P.; Gois, Pedro M. P.; Mata, Maria L. E. N.; Cabrita, Eurico J.; Afonso, Carlos A. M.. "Studies on the Preparation of 4-Ethoxyalkyliden and 4-Aminoalkyliden-5(4H)-oxazolones". Synthetic Communications 33 8 (2003): 1285-1299. http://dx.doi.org/10.1081/scc-120018688.
    10.1081/scc-120018688
Livro
  1. Aguiar, S.; Dias, J.; Manuel, A.M.; Russo, R.; Gois, P.M.P.; da Silva, F.A.; Goncalves, J.. Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads. 2018.
    10.1016/bs.apcsb.2018.03.002
  2. Antonio, J.P.M.; Farias, G.D.V.; Santos, F.M.F.; Oliveira, R.; Cal, P.M.S.D.; Gois, P.M.P.. Boron-Nitrogen Bond: A Useful Molecular Construction Tool. 2016.
    10.1002/9781119113874.ch2
  3. Candeias, N.R.; Trindade, A.F.; Gois, P.M.P.; Afonso, C.A.M.. The Wolff Rearrangement. 2014.
    10.1016/B978-0-08-097742-3.00325-6
  4. Monteiro, C.M.; Trindade, A.F.; Gois, P.M.P.; Afonso, C.A.M.; Trindade, Alexandre F.; Gois, Pedro M. P.; Afonso, Carlos A. M.. Recyclable Stereoselective Catalysts. 2011.
    10.1002/9781118087992.ch1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/11/21 Exploring Boron Reagents for the Assembly of Functional Bioconjugates 11th PEGS Europe, Protein & Antibody Engineering Summit
PEGS Europe (Lisboa, Portugal)
2019/10/23 Boron a Useful Element for Chemical Biology Seminar – Chemistry Department University of Vienna
University of Vienna (Vienna, Áustria)
2019/09/26 Boron a Useful Element for Chemical Biology Seminar – Max Planck Institute for Polymer Research
Max Planck Institute for Polymer Research (Mainz, Alemanha)
2019/01/16 Functional Linkers for Targeted Delivery Seminar - Chimie Paristech PSL University
Paristech PSL University (Paris, França)
2019/01/15 Functional Linkers for Targeted Delivery ITN Protein Conjugates Winter School
Institut Curie (Paris, França)
2018/07/20 Functional Linkers for Targeted Delivery Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry
Italian Chemical Society (Palermo, Itália)
2018/07/17 Iminoboronates: Functional Linkers for Targeted Delivery Chemistry Department Seminars university degli studi milano
university degli studi milano
2018/06/26 Functional Linkers for Targeted Delivery 16th Boron Chemistry Meeting in the Americas
Boston College (Boston, Estados Unidos)
2018/03/20 Exploring iminoboronates in the assembly of reversible bioconjugates 255th ACS National Meeting
ACS (New Orleans, Estados Unidos)
2017/07/24 Not that Boring: Boron a useful element for chemical biology UCL - Department of Chemistry Seminars
University College of London (London, Reino Unido)
2017/04/10 Make it Function - Playing with Reversibility 5ºENEQ
Portuguese Chemical Society (Coimbra, Portugal)
2016/10 Iminoboronates: A useful construction tool for chemical biology City college of New York, Chemistry Department Seminars
City college of New York (New York City, Estados Unidos)
2015/09/02 Boronic acid: A useful building block for chemical biology International Symposium on Synthesis and Catalysis
Universidade de Évora (Évora, Portugal)
2015/03/01 B-N dative bond: A useful tool to modify proteins and to assemble tumor targeting conjugates FloHet, GAINESVILLE
Florida University (Florida, Estados Unidos)
2014/09/27 Boron based dynamic bonding: an emerging tool for synthesis and bioconjugation CulturChem Seminars
UPMC (Paris, França)
2014/09/19 Exploring dynamic bonds to modulate the activity and structure of proteins iMed.ULisboa Seminars
iMed.ULisboa (Lisboa, Portugal)
2014/09/19 Boron based dynamic bonding: an emerging construction tool for Chemical Biology DEPARTMENT OF CHEMISTRY Seminars
UNIVERSITY OF CAMBRIDGE
2014/05/14 Exploring Boronic Acids as a Construction Tool in Chemical biology Huelva University Chemistry Department Seminars
Huelva University (Huelva, Espanha)
2014/04/29 Boron based dynamic bonding: an emerging tool for Bioconjugation 4º PYCHEM
Portuguese Chemical Society (Coimbra, Portugal)
2014/02/10 Unraveling Boron Based Biologics JORTEC
FCT/UNL (Almada, Portugal)
2013/06/14 Catalysts or ligands! The dual life of N-Heterocyclic Carbenes Vicente Seabra's Award - SPQ
Portuguese Chemical Society (Aveiro, Portugal)
2013/05/24 Mass Spectroscopy an invaluable tool to unravel the mechanism of action of N-B heterocycles Seminario - Faculdade de Ciência da UL
Faculdade de Ciência da UL (Lisboa, Portugal)
2013/05/17 Boron promoted assembly of new human neutrophile elastase inhibitors 1st Symposium on medicinal chemistry
Minho University (Braga, Portugal)
2013/04/09 Boron promoted assembly of simple building blocks as an efficient strategy to modify proteins and discover biological active heterocycles Portuguese Young Organic Chemist Award -SPQ
Portuguese Chemical Society (Lisboa, Portugal)
2012/09/02 Metal-Organo multicatalysis: An emerging concept XXV international Conference on organometallic Chemistry (XXV ICOMC)
ICOMC (Lisboa, Portugal)
2012/07/12 Harnessing the N-B Bond as a Strategy to Modify Proteins and Assemble Heterocycles with a Natural Product-Like Framework Organic Chemistry Symposium (6SPJ-OCS) - Eurojoc - Invited Plenary
Portuguese Chemical Society (Lisboa, Portugal)
2012/07/12 Boron promoted assembly of simple building blocks as an efficient strategy to modify proteins and discover biological active heterocycles ESOC
ESOC (Marseille, França)
2012/03/12 Cooperative Metal-Organo Catalysis: An emerging Concept Seminários do Instituto de Química, Universidade de Campinas
Universidade de Campinas (Campinas, Brasil)
2012/03/12 NHCs: Catalysts and/or Ligands: The dual life of a molecule in Cooperative Metal-Organo Catalysis Seminários do Instituto de Química, Universidade de São Paulo
Universidade de São Paulo (São Paulo, Brasil)
2011/07/03 Cooperative Metal-Organo Catalysis: The Best of Two Worlds! XXII Encontro Nacional da SPQ
Portuguese Chemical Society (Braga, Portugal)
2010/01/29 Tuning the reactivity of Rhodium and Iron using N-Heterocyclic carbenes Seminars and Colloquia at UCL Chemistry
UCL Chemistry (London, Reino Unido)
2009/10/28 C-C and C-X bond formation using metal-catalysed processes and Multicomponent-Reactions Seminários Científicos - Hovione e Universidades
Hovione SA (Loures, Portugal)
2009/10/19 Towards molecular complexity: C-C bond formation in water using Metals and MCR Flash Conference on Water
Era Chemistry (Alemanha)
2009/07/16 Catalysis and MCRs useful approaches towards C-C and C-X bond formation Young Investigator Workshop Chateau Liblice Czech Republic
Euchems (Liblice, República Checa)
2008/04/02 A perfect structural match of NHC Ligands onto Rh dimers induces subtle reactivity: The efficient Alkylation of Aldehydes Ciclo de conferencias do DQ-FCT/UNL
DQ-FCT/UNL (Almada, Portugal)
2007/09/23 Axial coordination of NHC Rh dimers: A perfect structural match indices subtle reactivity 8º Encontro Nacional de Ctatálise e Materiais Porosos
Portuguese Chemical Society (Lamego, Portugal)
2004/11/23 Dirhodium(II) Catalysed Intramolecular C-H Insertion on diazo-(diethoxyphosphoryl)acetamidas, an Expeditious way to prepare Heterocycles TransMediterranean Colloquium on Heterocyclic Chemistry (TRAMECH 2004).
(Marrahech, Marrocos)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2020/05/01 - 2024/05/01 Boron a Hot-Spot in the Periodic Table for Chemical Biology
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/01/01 - 2023/01/01 Development and Scale-Up of Peptide Drug Conjugates
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/01/01 - 2021/01/01 New bioconjugation strategies for selective cysteine functionalization
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/01/01 - 2021/01/01 Design of ROS Sensitive Traceless Linkers for Drug Delivery
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/01/01 - 2021/01/01 Targeted delivery of boronic acids through bioconjugation
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/01/01 - 2020/01/01 Cysteine Functionalization in the Synthesis of Complex and Well-Defined Bioconjugates
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/01/01 - 2020/01/01 Design of boronated multifunctional tumor-targeting drug conjugates
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/01/01 - 2019/01/01 Chemical site-selective functionalization of proteins with boronic acids
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/01/01 - 2018/01/01 Iminoboronates as useful scaffolds for tumor targeting
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/01/01 - 2017/01/01 3-Hydroxy-quinolin-2(1H)-ones, a useful scaffold: Synthesis and biological evaluation
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/01/01 - 2015/01/01 Síntese de ligandos bifuncionais quirais para o desenvolvimento de reacções multicomponente com catalisadores heterobimetálicos: Funcionalização de olefinas heteroaromáticas com potencial Atividade biológica
Coorientador
2010/01/01 - 2014/01/01 NEW TOOLS FOR CHEMICAL MODIFICATION OF PROTEINS
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/01/01 - 2014/01/01 Boronic acids as partners in Multicomponent reactions
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/01/01 - 2010/01/01 NHC-diRhodium (II) complexes Synthesis, Chracterization and catalytic evaluatiuon
Coorientador de Alexandre Trindade
Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2004/11/23 - 2004/11/27 TransMediterranean Colloquium on Heterocyclic Chemistry (TRAMECH 2004) Marrahech, Marrocos
Distinções

Prémio

2023 Scientific Award in Chemistry and Chemical Engineering
2022 Pioneering Investigator 2022 by Chemical Communication
Royal Society of Chemistry, Reino Unido
2013 Portuguese Young Organic Chemistry Award
Sociedade Portuguesa de Química, Portugal
2013 Emerging Investigator 2014- Chemical Communications
Royal Society of Chemistry, Reino Unido
2012 Vicente Seabra Medal (best chemist under 40)
Sociedade Portuguesa de Química, Portugal
2008 Honor Mention - UTL Young Researcher Award
Universidade de Lisboa Instituto Superior Técnico, Portugal
2001 School Merit Award
Universidade Nova de Lisboa, Portugal

Título

2023 President of the Medicinal Chemistry and Chemical Biology Division
Sociedade Portuguesa de Química, Portugal
2019 Coordinator of the SPQ division Chemistry for Life Sciences
Sociedade Portuguesa de Bioquímica, Portugal

Outra distinção

2023 General Secretary (adjunct)
Sociedade Portuguesa de Química, Portugal
2016 Vice presidente da divisão de química orgânica
Sociedade Portuguesa de Química, Portugal
2014 President of the Portuguese Chemical Society Lisbon division
Sociedade Portuguesa de Química, Portugal
2012 European Journal of Organic Chemistry plenary lecture at the 6SPJ
2012 2012 FCT Investigator - Development grant
Fundação para a Ciência e a Tecnologia, Portugal
2009 Portuguese representative at the Young Investigator Workshop
Sociedade Portuguesa de Química, Portugal