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Inês Caria is a PhD student at iMed.ULisboa (Faculty of Pharmacy, University of Lisbon). Her background includes a bachelor in Molecular and Cellular Biology and a master in Molecular Genetics and Biomedicine. Currently, her main focus is to clarify the cytoprotective mechanisms of neuronal specific-CYP46A1 that may correct autophagy and mitophagy defects, and ameliorate neuroinflammation and cholesterol intracellular trafficking in Niemman's Pick type C1 Disease. So far, her work has been translated into several poster communications in national meetings and in an international conference and a recent publication in a journal. During her academic journey she continues to actively participate in activities that involve promoting science to younger generations (promoted by ¿Ciência Viva¿), as well as in participating in the iMed.ULisboa Postgraduate Students Commission (ipSC) responsible for organizing the yearly iMed.ULisboa Meeting.
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Identification

Personal identification

Full name
Inês de Sousa Caria

Citation names

  • Caria, Inês

Author identifiers

Ciência ID
2C16-FD3F-A9C2
ORCID iD
0000-0003-3222-0481

Email addresses

  • ines.desousacaria@gmail.com (Professional)

Telephones

Mobile phone
  • 927330785 (Personal)

Addresses

  • Rua Francisco Roque Aguiar, Nº19, R/C Frente, Oeiras, 2780-056, Oeiras, Oeiras, Portugal (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Education
Degree Classification
2022/07/13 - 2026/07/13
Ongoing
 PhD in Pharmacy (Doutoramento)
Major in Cellular and Molecular Biology
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/12
Concluded
 STEM Cell Technologies (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Lisboa Faculdade de Farmácia, Portugal
 18
2023/12
Concluded
 Curso Pós-Graduado de Atualização de Ciências em Animais de Laboratório - Categoria B (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 17
2023/02
Concluded
 Multidisciplinary Project-Based Learning in Pharmacy (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Lisboa Faculdade de Farmácia, Portugal
 19
2021/07 - 2022/07
Concluded
 Methods and Techniques for Scientific Research 2022 (Non-Degree Course) (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2020/04
Concluded
 Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Unanswered Role of Cholesterol Homeostasisin Parkinson’s Disease" (THESIS/DISSERTATION)
 18
2014 - 2017
Concluded
 Cellular and Molecular Biology (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2022/07/13 - Current Research Trainee (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07/12 - 2022/07/13 Research Trainee (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2020 Research Trainee (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2020/10/16 - 2021/03/26 Mathematics and Natural Sciences Tutor Centro de Estudos 9 de Abril, Portugal
2017/01 - 2017/02 Professional Internship Laboratório de Imunidade (CHLO), Portugal
Hospital de São Francisco Xavier, Portugal
Projects

Contract

Designation Funders
2021/07/12 - 2022/07/12 PGC-1alpha Isoforms as novel Therapeutic targets in Parkinson's Disease
PTDC/MED-FSL/30104/2017
Research Fellow
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Ongoing
2018 - 2020 PGC-1alpha Isoforms as novel Therapeutic targets in Parkinson's Disease
PTDC/MED-FSL/30104/2017
Other
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Outputs

Publications

Conference abstract
  1. Nunes, Maria; Caria, Ines; Carvalho, Andreia; Costa, Daniela; Castro-Caldas, Margarida; Gama, Maria; Rodrigues, Elsa; Ruas, Jorge. "Unanswered role of cholesterol homeostasis in Parkinson's disease". 2019.
    10.3389/conf.fncel.2019.01.00024
Conference poster
  1. Caria, Inês; Nunes, Sofia; Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Mateus, Joana; Almeida, Rita Mendes; et al. "CYP46A1 Expression in NPC1 Cells May Ameliorate Autophagic Dysfunction By Facilitating Autophagosome-Lysosome Fusion". Paper presented in 20th International Symposium of the Portuguese Society for Metabolic Disorders, 2024.
  2. Caria, Inês; Nunes, Sofia; Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Mateus, Joana; Castro-Caldas, Margarida; et al. "How CYP46A1 May Influence Autophagy in Cellular and Animal Models of Niemann-Pick Type C Disease". Paper presented in XV iMed.ULisboa Postgraduate Students Meeting, 2024.
  3. Caria, Inês; Nunes, Sofia; Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Mateus, Joana; Almeida, Rita Mendes; et al. "CYP46A1 Ameliorates Autophagic Block In NPC1 KO Hela Cells By Facilitating Direct Autophagosome-Lysosome Fusion". Paper presented in XIV Encontro de Estudantes Pós-Graduados do iMed.ULisboa, 2023.
  4. Caria, Inês; Maria João Nunes; Viviana Ciracci; Mariana Castanheira; Andreia Neves Carvalho; Margarida Castro-Caldas; Maria João Gama; Elsa Rodrigues; Jorge Ruas. "Complex I-inhibition leads to cholesterol trafficking impairment in a model of Parkinson’s Disease". Paper presented in 13th iMed.ULisboa Postgraduate Students Meeting, 2022.
  5. Caria, Inês; Nunes, Maria João; Ciracci, Viviana; Castanheira, Mariana; Carvalho, Andreia Neves; Castro-Caldas, Margarida; Gama, Maria João; Rodrigues, Elsa; Ruas, Jorge. "Waiting for the Green Light: Is there a cholesterol traffic jam in Parkinson's Disease?". Paper presented in 5.ª Conferência Anual da redeSAÚDE "A Health Research Agenda Towards 2030", 2021.
  6. Caria, Inês; Nunes, MJ; Carvalho, AN; Castro-Caldas, M; Gama, MJ; Rodrigues, E; Ruas, JL. "Inhibition of the mitochondrial complex I by a Parkinson's Disease-inducing neurotoxin leads to a NPC1 phenotype in neuronal cells". Paper presented in 16th International Symposium of the Portuguese Society of Metabolic Disorders, 2020.
  7. Caria, Inês; Carvalho, Andreia N.; Costa, Daniela; Castro-Caldas, Margarida; Gama, Maria João; Rodrigues, Elsa; Ruas, Jorge L.. "Deciphering the role of cholesterol homeostasis in Parkinson's disease". Paper presented in 5th Annual Meeting of the Mind-Brain College and 17th Biomedical Engineering Meeting, 2019.
  8. Caria, Inês; Nunes, Maria J.; Carvalho, Andreia N.; Costa, Daniela; Castro-Caldas, Margarida; Gama, Maria J.; Rodrigues, Elsa; Ruas, Jorge L.. "Deciphering the role of cholesterol homeostasis in Parkinson's disease". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting & 4rd i3DU Meeting, 2019.
  9. Nunes, Maria J.; Caria, Inês; Carvalho, Andreia N.; Costa, Daniela; Castro-Caldas, Margarida; Rodrigues, Elsa; Ruas, Jorge L.. "Deciphering the role of cholesterol homeostasis in Parkinson's disease". Paper presented in The 7th Mediterranean Neuroscience Conference, 2019.
  10. Nunes, Maria J.; Caria, Inês; Carvalho, Andreia N.; Costa, Daniela; Castro-Caldas, Margarida; Gama, Maria J.; Rodrigues, Elsa; Ruas, Jorge L.. "Unanswered role of cholesterol homeostasis in Parkinson's disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
Journal article
  1. Caria, Inês; Nunes, Maria João; Ciraci, Viviana; Carvalho, Andreia Neves; Ranito, Catarina; Santos, Susana G.; Gama, Maria João; et al. "NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 2 (2024): 166980. http://dx.doi.org/10.1016/j.bbadis.2023.166980.
    10.1016/j.bbadis.2023.166980
  2. Kovalchuk, Daria Alexandrovna; Anjo, Sandra I.; Nunes, Maria João; Branco, Vasco; Santos, Fabiana; Caria, Inês; Castro-Caldas, Margarida; et al. "Cysteine redox post-translational modifications: the missing link between redox-signalling and mitochondrial dynamics and function in Parkinson's disease?". Free Radical Biology and Medicine 201 (2023): 35. http://dx.doi.org/10.1016/j.freeradbiomed.2023.03.142.
    10.1016/j.freeradbiomed.2023.03.142
Thesis / Dissertation
  1. Caria, Inês. "Unanswered Role of Cholesterol Homeostasis in Parkinson's Disease". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2020.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/03/14 Apresentação de seminário "Porque morrem os neurónios?" a alunos do 9º e 12ºano, dentro do programa da Semana Internacional do Cérebro 2022 organizado pelo Centro de Ciência Viva. Os Neurocientistas vão às Escolas
Ciência Viva (Lisboa, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/11/30 - 2021/11/30 Participação num congresso cientifico com um poster e um pitch oral intitulado "Waiting for the Green Light: Is there a cholesterol traffic jam in Parkinson's Disease?"
Conference
 5.ª Conferência Anual da redeSAÚDE "A Health Research Agenda Towards 2030"
Universidade de Lisboa, Portugal
2019/11/12 - 2019/11/12 Apresentação de um poster cientifico "Deciphering the role of cholesterol homeostasis in Parkinson's disease".
Conference
 5th Annual Meeting of the Mind-Brain College and 17th Biomedical Engineering IST/FMUL
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/07/15 - 2019/07/15 Apresentação de um poster cientifico "Deciphering the role of cholesterol homeostasis in Parkinson's disease".
Conference
 11th iMed.ULisboa Postgraduate Students Meeting & 4rd i3DU Meeting
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2019 - 2019 Apresentação de pequenas palestras e atividades intituladas "O Cérebro Trocado em Miúdos!", que resultou do programa "Cientificamente Provável", uma iniciativa colaborativa entre escolas (através da rede de bibliotecas) e os centros de investigação e universidades.
Workshop
 Cientificamente Provável 2019
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2017 Representante da Licenciatura de Biologia Celular e Molecular na iniciativa da Futurália 2017.
Exhibition
 Futurália 2017
Feira Internacional de Lisboa, Portugal
Distinctions

Other distinction

2020 Honorable Mention for Conference Poster in the 16th International Symposium of the Portuguese Society for Metabolic Disorders.