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Ana Matos has completed the Bachelor's Degree in Biochemistry in July of 2019 by Universidade de Lisboa, Faculdade de Ciências and the Master in Biochemistry by Universidade de Lisboa, Faculdade de Ciências in March of 2022. Her curricular research training was held at the Neuroinflammation, Signaling and Neuroregeneration Lab coordinated by Professor Dora Brites, at iMed, Faculty of Pharmacy of the University of Lisbon and developed under the project FCT- PTDC/MED-NEU/31395/2017. She also concluded a Post-Graduate Course on Laboratory Animal Science in 2021/09/24 by Universidade de Lisboa, Faculdade de Farmácia. Ana has technical control over laboratorial techniques and equipment, namely RT-qPCR, Immunocytochemistry, Fluorescence Microscopy, Western Blot, Transfection (modulation of microRNAs), maintenance of iPSC cultures, primary cell cultures and tissue from mice spinal cord models and basic knowledge on Bioinformatics software (ImageJ, iBright and GraphPad). Works in the area of Natural sciences within Biological Sciences with emphasis on Biochemistry. Ana attended an online course from the Coursera platform by the University of Michigan on Human Neuroanatomy. In her curriculum Ciência Vitae, the most frequent terms in the context of scientific, technological and artistic-cultural output are: Amyotrophic Lateral Sclerosis; Neuroscience and Molecular Biology. Ana has a certificate of Proficiency in English by the University of Cambridge, concluded the 3rd grade of violin and musical training by Física Music Academy associated with the National Music Academy and 5 years of piano training by Canoa Music School. She also concluded the 4th level of horse riding and is an amateur photographer with basic knowledge on Photoshop editing software.
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Identification

Personal identification

Full name
Ana Teresa Mateus Aspra de Matos
Date of birth
1998/09/13
Gender
Female

Citation names

  • Matos, Ana Teresa

Author identifiers

Ciência ID
CB1E-9133-E112
ORCID iD
0000-0002-4030-8822

Email addresses

  • matos.ana.teresa@gmail.com (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2022/11/01 - 2026
Ongoing
 Doutoramento em Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/03/24 - 2022/05/16
Concluded
 Anatomy: Human Neuroanatomy (Outros)
University of Michigan, United States
2019/09/04 - 2022/03/16
Concluded
 Bioquímica (Mestrado)
Major in Bioquímica Médica
Universidade de Lisboa Faculdade de Ciências, Portugal
"Dissertation title: "miRNA Modulation in ALS Spinal Microglia", with a grade of 20/20 and under the project PTDC/MED-NEU/31395/2017 and LISBOA-01-0145-FEDER-031395" (THESIS/DISSERTATION)
 18/20
2021/09/24
Concluded
 Ciências em Animais de Laboratório - Parte Prática (Curso de Especialização Tecnológica)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 17/20
2021/07/14
Concluded
 Ciências em Animais de Laboratório - Parte Teórica (Curso de Especialização Tecnológica)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 16/20
2016/09/12 - 2019/07/23
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2022/11/01 - Current Contracted Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09 - 2021/12 Research Trainee (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Projects

Grant

Designation Funders
2020/09/14 - 2022/03/16 Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis ALS
PTDC/MED-NEU/31395/2017
Master Student
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference poster
  1. Matos, Ana Teresa; Borralho-Martins, Nísia; Rita Barbosa; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "miRNA Engineering of Pathological Microglia as a Promising Therapeutic Strategy for Amyotrophic Lateral Sclerosis". Paper presented in FENS Regional Meeting, 2023.
  2. Matos, Ana Teresa; Raquel Martin Baquero; Marta Gómez-Almería; Ana Martínez; Carmen Rodríguez-Cueto; Eva de Lago; Vaz, Ana Rita; Brites, Dora. "Promise of a Protein CK-1d Inhibitor for Reshaping Inflammatory miRNAs in the TDP-43 (A315T) Transgenic Mice". Paper presented in VII Symposium of th Portuguese Glial Network, 2023.
  3. Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Inhibiting miR-125b overexpression in ALS spinal microglia restores their homeostatic profile". Paper presented in VI Symposium of the Portuguese Glia Network, 2022.
  4. Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "miR-125b inhibitor recovers microglial homeostatic profile conveying neuroprotection in ALS". Paper presented in iMed.ULisboa Meeting 2022, 2022.
  5. Vaz, Ana Rita; Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Barbosa, Marta; Brites, Dora. "Regeneration of microglia homeostasis and paracrine signaling in models of spinal ALS disease". 2021.
  6. Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Studying the benefits of the regulation of inflammatory-miRNAs in rescuing microglia function in ALS". Paper presented in iMed.ULisboa Meeting 2021, 2021.
  7. Martins, Nísia; Matos, Ana Teresa; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Testing the benefits of the miRNA-reshaped secretome from motor neurons in spinal 3D cultures using ALS models". Paper presented in iMed.ULisboa Meeting 2021, 2021.
Journal article
  1. Loch-Neckel, Gecioni; Matos, Ana Teresa; Vaz, Ana Rita; Brites, Dora. "Challenges in the development of drug delivery systems based on small extracellular vesicles for therapy of brain diseases". Frontiers in Pharmacology (2022): https://www.frontiersin.org/articles/10.3389/fphar.2022.839790/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Pharmacology&id=839790.
    Published • 10.3389/FPHAR.2022.839790

Other

Other output
  1. Papel do DHA e sinergia com a Vitamina B12 na prevenção das doenças neurodegenerativas. Monography for the purpose of the Processes in Nutrition, Environment and Health subject from the Master in Biochemistry by the Faculty of Sciences, University of Lisbon. 2020.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/08 INFLAMMATORY MIRNAS AS BIOMARKERS AND THERAPEUTIC TARGETS IN ALS DISEASE MODELS 5 4 th Meeting of the Portuguese Society of Pharmacology, 4 2 nd Meeting of Clinical Pharmacology and 2 3 r d Meeting of Toxicology
(Lisbon, Portugal)
2023/11/18 Terapias emergentes na ELA: explorando o composto IGS-2.7 na preservação da homeostasia celularno ratinho mTDP-43 I Seminário APELA(R) para as Doenças Neurodegenerativas
Associação APELA (Portugal)
2023/11/07 Therapeutic Strategies Targeting miR-125b expression to revert ALS malfunctioning Microglia Virtual Workshop on Biochemistry of Ageing
(Portugal)
2022/07/19 Regulation of miR-125b in senescent-like microglia recovers their homeostatic immune profile and prevents spinal cord pathogenicity Innovative Models And Therapies For Amyotrophic Lateral Sclerosis online workshop
(Lisbon, Portugal)
2021/02 miRNA Modulation in ALS Spinal Microglia 3rd Biochemistry Masters Meeting
Faculdade de Ciências - Universidade de Lisboa (Lisboa, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/04/01 - Current Immunological role of glia in synucleinopathies by Professor Laurent Roybon (01/04)
Seminar
 Neurocience Seminars
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2021/11/10 - 2021/11/10 Modulation of TDP-43 with protein kinase inhibitors, a new avenue for ALS pharmcotherapy by Professor Ana Martinez
Seminar
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/10/01 - 2021/10/15 -Translational neuroimmunology in multiple sclerosis pathogenesis by Professor Adelaide Fernandes (1/10) -Regulation of tumour immune microenvironment using advanced neuro-immuno-therapy by Professor Helena Florindo (8/10) -Macromolecular strategies for enhancing immunotherapy responses by Professor Lutz Nuhn (15/10)
Seminar
 Promoting Health by Adressing the Disease
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2021/09/01 - 2021/09/01 -On brains and vessels: How perivascular fibroblasts contribute to ALS neurodegeneration by Professor Sebastian Lewandowski
Seminar
 Sattelite Seminar
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/02/12 - 2021/04/16 Seminars: - Translating discoveries to improve health options by Professor María J. Vincent (12/02) - Neuro-immune interactions: a holistic paradigm in CNS pathology and regeneration by Professor Dora Brites (26/02) - Getting published in 2021 and beyond: how to adapt to a rapidly changing publication landscape by Professor Ruben Ragg (12/03) - Science under the microscope: on science communication by Professor Joana Lobo Antunes (09/04) - Metabolic Regulation of Adult Neurogenesis by Professor Susana Solá (16/04)
Seminar
 iMed.ULisboa Seminars
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2021/03/30 - 2021/03/30 Session 1: Emerging technologies and advanced models -Scalable generation of cerebellar organoids from human pluripotent stem cells by Professor Teresa Pereira -Ageing Barriers in cellular reprogramming by Professor Bruno Bernardo de Jesus -The choroid-plexus brain barrier: in and out of the brain in aging by Professor Joana Palha -Progeria as a model of physiological vascular ageing? by Professor Lino Ferreira
Workshop
 Virtual Workshop on Biochemistry of Ageing
Sociedade Portuguesa de Bioquímica, Portugal
2021/03/30 - 2021/03/30 Session 2: Disease mechanisms and therapeutic strategies -The landscape of adaptive evolution of a gut commensal bacteria in aging mice by Professor Hugo Barreto -Telomere shortening creates a pro-tumorigenic environment by Professor Bruno Miguel Lopes-Bastos -The potential of microRNAs modulation in Alzheimer’s Disease by Professor Ana Teresa Viegas -Inhibition of age-associated genomic instability: emerging strategy to delay cellular senescence and aging by Professor Elsa Logarinho
Workshop
 Virtual Workshop on Biochemistry of Ageing
Sociedade Portuguesa de Bioquímica, Portugal
2021/03/17 - 2021/03/17 Brain Gain - À Descoberta das Neurociências -Patologias do cérebro e terapias by Professora Ana Azevedo -Estimulação cerebral profunda - DBS by Professor Rui Vaz
Seminar
 Brain Gain - À Descoberta das Neurociências
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/02/26 - 2021/02/26 Warm-up Olimpiadas Universitárias da Bioquímica (26/02/2021) Zebrafish avatars towards personalized medicine and the study of innate-immune interactions by Professora Rita Fior
Seminar
 Warm-up Olimpiadas Universitárias da Bioquímica
2019/04/12 - 2019/04/14 Encontro Nacional de Estudantes de Bioquímica
Conference
 XII ENEBIOQ - National Biochemistry Students Conference
Universidade de Aveiro, Portugal
2019/04/13 - 2019/04/13 Workshop about Phage Therapy conducted by Dr. Adelaide de Almeida
Workshop
 XII ENEBIOQ - National Biochemistry Students Conference
Universidade de Aveiro, Portugal
2018 - 2019 -Mitochondrial Biology and Neurodegeneration by Professor Vanessa Morais -Retinal Degeneration and Gene Therapy by Professor Miguel Seabra -Enzyme Evolution by Professor Lígia O. Martins -Cancer Immunology by Professor Bruno Silva-Santos
Seminar
 Biochemistry Masterclass Seminars
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/06/29 - 2017/07/03 The Universidade de Lisboa organizes Summer at ULisboa to give students an opportunity to get to know and experiment its rhythm and its academic spirit. The Participants get to know and interact dynamically in labs, classrooms, research centers and other areas that are a part ULisboa’s daily life.
Other
 Summer at ULisboa
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal