???global.info.a_carregar???
Dr. Colin McVey completed his Bachelor's degree in Biochemistry in 1991 at the Queen's University in Belfast. He obtained his master’s in clinical laboratory medicine in the Dept of Haematology, from the same university in 1992, and his Doctor of Philosophy in Chemistry from the University of York in 2000. He has worked as a Research Assistant, Postdoc and Auxiliary Researcher at various academic institutions in the UK and Portugal. Since 2014, he has been a Principal Investigator (Research) at Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica. Dr. Colin McVey's research interests are in Biological Sciences with an emphasis on Biophysics, related to the fields of Virology and DNA binding proteins. In his professional activities, he has interacted with 132 collaborator(s) in co-authorship of scientific papers. He has published in high-impact journals and 4 book chapters. His scientific output has focussed on Structural Biology, in the areas of protein crystallization, and DNA viruses, particularly in the area of herpesvirus biology. His current focus is on the multifaceted latency-associated nuclear antigen (LANA) and its role in viral latency, DNA binding mechanism and chromatin modulation.
Read full resume ↓
Identification

Personal identification

Full name
Colin McVey

Citation names

  • McVey, Colin E.

Author identifiers

Ciência ID
EC1C-6BBD-4E1C
ORCID iD
0000-0001-7457-2130

Addresses

  • Instituto de Tecnologia Química e Biológica . Structural Virology Lab, Macromolecular Crystallography Unit, ITQB, Av.de República, EAN, 2780-157, Oeiras, Oeiras, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Virology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English (Mother tongue)
Portuguese Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
1996/10/01 - 2000/02/28
Concluded
 Chemistry (Doctor of Philosophy)
University of York Department of Chemistry, United Kingdom
"Structure function studies of Penicillin G acylase from E. coli" (THESIS/DISSERTATION)
 DPhil
1992
Concluded
 Masters in Clinical Laboratory Medicine (Master)
Queen's University Belfast, United Kingdom
"Expression cloning of murine erythropoietin" (THESIS/DISSERTATION)
 M.Med.Sc
1991
Concluded
 Biochemistry (Bachelor)
Queen's University Belfast Centre for Biomedical Sciences Education, United Kingdom
"N/A" (THESIS/DISSERTATION)
 BSc (Hons)
Affiliation

Science

Category
Host institution 		Employer
2019/10/01 - Current Principal Investigator (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/02/01 - 2019/01/31 Principal Investigator (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009/07/01 - 2014/01/31 Auxiliary Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2004/04/01 - 2007/03/31 Postdoc (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2001/09/01 - 2004/03/31 Postdoc (Research) Imperial College Faculty of Medicine - Saint Mary's Campus, United Kingdom
1999/02/01 - 2001/08/31 Postdoc (Research) Sir William Dunn School of Pathology, United Kingdom
1993/03/01 - 1999/09/30 Research Assistant (Research) University of York Department of Chemistry, United Kingdom

Others

Category
Host institution 		Employer
2007/07/01 - 2009/06/30 Spine2 deputy coordinator (Oeiras, Portugal) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projects

Grant

Designation Funders
2014/10 - 2019/10 STRUCTURAL STUDIES ON LANA INTERACTIONS AND ITS IMPACT ON TUMOUR VIRAL LATENT INFECTION
Provided by PTCRIS: 147538
IF/01023/2013/CP1173/CT0003
Principal investigator
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2011/11 - 2015/07 Pathogenesis of Kaposi's sarcoma herpesvirus LANA
Provided by PTCRIS: 116380
3529675
Principal investigator
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Medicina Molecular, Portugal

Harvard Medical School, United States
Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2014/08 GRIM-19, a novel protein involved in cell apoptosis: structure-function characterization
Provided by PTCRIS: 113064
 Fundação para a Ciência e a Tecnologia, I.P.
2006/07/01 - 2010/06/30 SPINE2-COMPLEXES Integrated project LSHG CT-2006-031220
LSHG-CT-2006- 031220
Researcher
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
 European Commission Seventh Framework Programme for Research and Technological Development Health
Concluded
2007/01 - 2008/12 Structure function studies of murine Toll-like receptors: Activation of the innate immune response
Provided by PTCRIS: 82296
 Fundação para a Ciência e a Tecnologia, I.P.
2005/05 - 2008/06 Structural genomics and human pathogenic bacteria
Provided by PTCRIS: 63856
 Fundação para a Ciência e a Tecnologia, I.P.
2005/09 - 2008/03 Structure function studies of murine Toll-like receptors: Activation of the innate immune response
Provided by PTCRIS: 55729
 Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2021/01/01 - 2025/12/31 Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

BioResources 4 Sustainability, Portugal

Universidade NOVA de Lisboa, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 iNOVA4Health - Programa de Medicina Translacional (iBET, CEDOC/FCM, IPOLFG e ITQB)
UID/Multi/04462/2019
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 4 - 2011-2012
PEst-OE/EQB/LA0004/2011
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/03/31 Estudos estruturais e funcionais de receptores Toll-like: Activação da resposta imunitária inata
POCI/SAU-IMI/55729/2004
Fundação Calouste Gulbenkian, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Gorynia, S.; Bandeiras, T.M.; Matias, P.M.; Pinho, F.G.; McVey, C.E.; Donner, P.; Carrondo, M.A.. RuvBL1 and RuvBL2 and their complex proteins implicated in many cellular pathways. 2012.
    10.1007/978-94-007-2530-0_5
Book chapter
  1. Gorynia, Sabine; Bandeiras, Tiago M.; Matias, Pedro M.; Pinho, Filipa G.; McVey, Colin E.; Donner, Peter; Carrondo, Maria Arménia. "RuvBL1 and RuvBL2 and Their Complex Proteins Implicated in Many Cellular Pathways". In NATO Science for Peace and Security Series A: Chemistry and Biology, edited by Carrondo, M.A.; Spadon, P., 55-63. Springer Netherlands, 2011.
    Published • 10.1007/978-94-007-2530-0_5
  2. Frazão, Carlos; McVey, Colin E.; Carrondo, MA. "Determinação da Estrutura da Ribonuclease II: uma enzima importante no controlo da expressão génica.". In Annualia, edited by Colaço, Jorge. Lisboa, Portugal: Editorial Verbo, 2007.
    Published
  3. Brannigan, J.A.; Ladurner, A.G.; McVey, Colin E.; Forney, L.J.. "Altered specificity mutants of penicillin acylase.". In In Perspectives on Protein Engineering, edited by Geisow M.; Epton, R., 124-126. United Kingdom: Mayflower Worldwide Ltd, 1995.
    Published
Conference abstract
  1. McVey, Colin E.. "Viral regulation of a histone methyltransferase". Paper presented in American Society for Virology Annual Meeting, Madison, 2022.
    Accepted
  2. Campos, Elisa J.; Asandei, Alina; McVey, Colin E.; dias, joão carlos; oliveira, asf; Soares, Claudio M.; Luchian, Tudor; Astier, Yann. "Sensing modified-gold nanoparticles with the a-hemolysin pore". Paper presented in 9th International Conference on Nanosciences & Nanotechnologies (NN12), Thessaloniki, 2012.
    Published
Conference poster
  1. Joana Batuca; McVey, Colin; Maria Arménia Carrondo; José Delgado Alves. "Anti-apolipoprotein A-I (ApoA-I) antibodies have different target epitopes in different clinical conditions". 2017.
    : https://doi.org/10.1016/j.atherosclerosis.2017.06.705
  2. Chitas, Rute; Ponnusamy, Rajesh; Custódio, Tânia F.; McVey, Colin E.. "Structural and biochemical analysis of LANA interactions with USP7". Paper presented in 20th International Workshop on Kaposi's Sarcoma Herpes Virus (KSHV) and Related Agents, 2017.
  3. Rute Chitas; Rajesh Ponnusamy; Tânia Custódio; McVey, Colin. "Structural and Biochemical Analysis of LANA interactions with USP7: Incorporation of a glutamine residue in substrate competition by KSHV LANA". Paper presented in 20th International Workshop on Kaposi ´s Sarcoma Herpes Virus (KSHV) and Related Agents, 2017.
  4. McVey, Colin E.; Marta Pires de Miranda; Pedro Simas. "Structural Virology of the Murid gamma-Herpesvirus 4 – Crystal structure of the latency-associated nuclear antigen (LANA) protein.". Paper presented in Eurovirology 2013: 5th European Congress of Virology, 2013.
  5. McVey, Colin E.; Marta Pires de Miranda. "“Improving crystal quality by combined Bioinformatics, Biophysical Characterization and Seeding Techniques.”". Paper presented in FEBS Practical Course. “Advanced Methods in Protein Crystallization V”, 19 to 22 June 2012 Academic and University Center at Nové Hrady, Czech Republic., 2012.
  6. McVey, Colin E.; Marta Pires de Miranda; Pedro Simas. "“Protein-protein interactions mediated by the gammaherpesvirus M2 protein”". Paper presented in EMBO meeting 2009 (Amesterdam, 29.Aug - 2 September 2009), 2009.
  7. McVey, Colin E.; Francisco Javier Enguita. "Crystal Structure of the Full-Length Sorbitol Operon Regulator SorC from Klebsiella pneumoniae: Structural Evidence for a Novel Transcriptional Regulation Mechanism". Paper presented in 25th European Crystallographic Meeting 16th to 21st. August 2009 in Istanbul, Turkey., 2009.
  8. McVey, Colin E.. "Nucleotide-binding Oligomerization Domain 2 (NOD2) interacts with its ligands through key domains two different approaches". Paper presented in SPINE2-COMPLEXES Annual meeting from July 15th to July 16th 2009. Lisbon, Portugal., 2009.
  9. McVey, Colin E.. "Biophysical characterization of the murine CARD-CARD domain of NOD2.". Paper presented in SPINE2-COMPLEXES Annual meeting from July 15th to July 16th 2009. Lisbon, Portugal., 2009.
  10. McVey, Colin E.. "A Scanning library approach to successful NLR expression.". Paper presented in SPINE2 First Annual Congress (Prague 8-10 June 2007), 2007.
  11. McVey, Colin E.; Barbas, Ana; Amblar, M.; Frazão, Carlos; Arraiano, C.M.; Carrondo, MA. "Crystallisation of and crystallographic analysis of RNase II from E. coli.". Paper presented in Protein Society Meeting, Barcelona, 2005.
  12. McVey, Colin E.. "Altering the substrate specificity of penicillin acylase". Paper presented in The Protein Society Second European Symposium, 1997.
Journal article
  1. Tan, Min; Li, Shijun; Juillard, Franceline; Chitas, Rute; Custódio, Tânia F; Xue, Han; Szymula, Agnieszka; et al. "MLL1 is regulated by KSHV LANA and is important for virus latency". Nucleic Acids Research 49 22 (2021): 12895-12911. http://dx.doi.org/10.1093/nar/gkab1094.
    Published • 10.1093/nar/gkab1094
  2. Pires de Miranda, Marta; Quendera, Ana Patrícia; McVey, Colin E.; Kaye, Kenneth M.; Simas, J. Pedro. "In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4". Journal of Virology 92 21 (2018): http://dx.doi.org/10.1128/jvi.01251-18.
    Open access • 10.1128/jvi.01251-18
  3. Habison, A.C.; de Miranda, M.P.; Beauchemin, C.; Tan, M.; Cerqueira, S.A.; Correia, B.; Ponnusamy, R.; et al. "Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA". PLoS Pathogens 13 9 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030456472&partnerID=MN8TOARS.
    10.1371/journal.ppat.1006555
  4. Campos, E.J.; McVey, C.E.; Astier, Y.. "Stochastic Detection of MPSA-Gold Nanoparticles Using a a-Hemolysin Nanopore Equipped with a Noncovalent Molecular Adaptor". Analytical Chemistry 88 12 (2016): 6214-6222. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975794177&partnerID=MN8TOARS.
    10.1021/acs.analchem.5b03558
  5. Cerqueira, S.A.; Tan, M.; Li, S.; Juillard, F.; McVey, C.E.; Kaye, K.M.; Simas, J.P.. "Latency-associated nuclear antigen E3 ubiquitin ligase activity impacts gammaherpesvirus-driven germinal center B cell proliferation". Journal of Virology 90 17 (2016): 7667-7683. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983567949&partnerID=MN8TOARS.
    10.1128/JVI.00813-16
  6. Pedersen, H.L.; Johnson, K.A.; Mcvey, C.E.; Leiros, I.; Moe, E.. "Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA". Acta Crystallographica Section D: Biological Crystallography 71 (2015): 2137-2149. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944217343&partnerID=MN8TOARS.
    10.1107/S1399004715014157
  7. Ponnusamy, R.; Petoukhov, M.V.; Correia, B.; Custodio, T.F.; Juillard, F.; Tan, M.; Pires De Miranda, M.; et al. "KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA". Nucleic Acids Research 43 20 (2015): 10039-10054. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949978455&partnerID=MN8TOARS.
    10.1093/nar/gkv987
  8. Li, S.; Tan, M.; Juillard, F.; Ponnusamy, R.; Correia, B.; Simas, J.P.; Carrondo, M.A.; McVey, C.E.; Kaye, K.M.. "The Kaposi sarcoma herpesvirus latency-associated nuclear antigen DNA binding domain dorsal positive electrostatic patch facilitates DNA replication and episome persistence". Journal of Biological Chemistry 290 47 (2015): 28084-28096. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947703640&partnerID=MN8TOARS.
    10.1074/jbc.M115.674622
  9. McVey, C.E.; Ferreira, M.J.; Correia, B.; Lahiri, S.; De Sanctis, D.; Carrondo, M.A.; Lindley, P.F.; et al. "The importance of the Abn2 calcium cluster in the endo-1,5-arabinanase activity from Bacillus subtilis Topical Issue in honor of Ivano Bertini. Guest editors: Lucia Banci, Claudio Luchinat". Journal of Biological Inorganic Chemistry 19 4-5 (2014): 505-513. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901949682&partnerID=MN8TOARS.
    10.1007/s00775-014-1105-x
  10. Campos, E.; McVey, C.E.; Carney, R.P.; Stellacci, F.; Astier, Y.; Yates, J.. "Sensing single mixed-monolayer protected gold nanoparticles by the a-hemolysin nanopore". Analytical Chemistry 85 21 (2013): 10149-10158. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887738853&partnerID=MN8TOARS.
    10.1021/ac4014836
  11. Pires De Miranda, M.; Lopes, F.B.; McVey, C.E.; Bustelo, X.R.; Simas, J.P.. "Role of Src homology domain binding in signaling complexes assembled by the murid gamma-herpesvirus M2 protein". Journal of Biological Chemistry 288 6 (2013): 3858-3870. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873692786&partnerID=MN8TOARS.
    10.1074/jbc.M112.439810
  12. Correia, B.; Cerqueira, S.A.; Beauchemin, C.; Pires de Miranda, M.; Li, S.; Ponnusamy, R.; Rodrigues, L.; et al. "Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency". PLoS Pathogens 9 10 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84887309755&partnerID=MN8TOARS.
    10.1371/journal.ppat.1003673
  13. Campos, E.; Asandei, A.; McVey, C.E.; Dias, J.C.; Oliveira, A.S.F.; Soares, C.M.; Luchian, T.; Astier, Y.. "The role of lys147 in the interaction between MPSA-gold nanoparticles and the a-hemolysin nanopore". Langmuir 28 44 (2012): 15643-15650. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868607116&partnerID=MN8TOARS.
    10.1021/la302613g
  14. Gorynia, S.; Bandeiras, T.M.; Pinho, F.G.; McVey, C.E.; Vonrhein, C.; Round, A.; Svergun, D.I.; et al. "Structural and functional insights into a dodecameric molecular machine - The RuvBL1/RuvBL2 complex". Journal of Structural Biology 176 3 (2011): 279-291. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455176998&partnerID=MN8TOARS.
    10.1016/j.jsb.2011.09.001
  15. de Sanctis, D.; McVey, C.E.; Enguita, F.J.; Carrondo, M.A.. "Crystal Structure of the Full-Length Sorbitol Operon Regulator SorC from Klebsiella pneumoniae: Structural Evidence for a Novel Transcriptional Regulation Mechanism". Journal of Molecular Biology 387 3 (2009): 759-770. http://www.scopus.com/inward/record.url?eid=2-s2.0-62049085612&partnerID=MN8TOARS.
    10.1016/j.jmb.2009.02.017
  16. De Sanctis, D.; Rêgo, A.T.; Marçal, D.; McVey, C.E.; Carrondo, M.A.; Enguita, F.J.. "Overexpression, purification and crystallization of the tetrameric form of SorC sorbitol operon regulator". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64 1 (2007): 22-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549029828&partnerID=MN8TOARS.
    10.1107/S1744309107060897
  17. Cooray, S.; Bahar, M.W.; Abrescia, N.G.A.; McVey, C.E.; Bartlett, N.W.; Chen, R.A.-J.; Stuart, D.I.; Grimes, J.M.; Smith, G.L.. "Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein". Journal of General Virology 88 6 (2007): 1656-1666. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249787896&partnerID=MN8TOARS.
    10.1099/vir.0.82772-0
  18. Frazão, C. *; McVey, Colin E. *; Amblar, M. *; Barbas, A.; Vonrhein, C.; Arraiano, C.M.; Carrondo, M.A.. Corresponding author: Arraiano, C.M.. "Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex". Nature 443 7107 (2006): 110-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748414894&partnerID=MN8TOARS https://www.nature.com/articles/nature05080#author-information.
    Published • 10.1038/nature05080
  19. McVey, C.E.; Amblar, M.; Barbas, A.; Cairrão, F.; Coelho, R.; Romáo, C.; Arraiano, C.M.; Carrondo, M.A.; Frazão, C.. "Expression, purification, crystallization and preliminary diffraction data characterization of Escherichia coli ribonuclease II (RNase II)". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62 7 (2006): 684-687. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745684855&partnerID=MN8TOARS.
    10.1107/S1744309106021506
  20. Bartlett, N.W.; Dumoutier, L.; Renauld, J.-C.; Kotenko, S.V.; McVey, C.E.; Lee, H.-J.; Smith, G.L.. "A new member of the interleukin 10-related cytokine family encoded by a poxvirus". Journal of General Virology 85 6 (2004): 1401-1412. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942633388&partnerID=MN8TOARS.
    10.1099/vir.0.79980-0
  21. Morillas, M.; McVey, C.E.; Brannigan, J.A.; Ladurner, A.G.; Forney, L.J.; Virden, R.. "Mutations of penicillin acylase residue B71 extend substrate specificity by decreasing steric constraints for substrate binding". Biochemical Journal 371 1 (2003): 143-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-0242286152&partnerID=MN8TOARS.
    10.1042/BJ20021383
  22. McVey, C.E.; Walsh, M.A.; Dodson, G.G.; Wilson, K.S.; Brannigan, J.A.. "Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism". Journal of Molecular Biology 313 1 (2001): 139-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035850792&partnerID=MN8TOARS.
    10.1006/jmbi.2001.5043
  23. Brannigan, J.A.; Dodson, G.G.; Done, S.H.; Hewitt, L.; McVey, C.E.; Wilson, K.S.. "Structural studies of penicillin acylase". Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology 88 1-3 (2000): 313-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033790948&partnerID=MN8TOARS.
  24. Suresh, C.G.; Pundle, A.V.; SivaRaman, H.; Rao, K.N.; Brannigan, J.A.; McVey, C.E.; Verma, C.S.; et al. "Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members". Nature Structural Biology 6 5 (1999): 414-416. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032915960&partnerID=MN8TOARS.
    10.1038/8213
  25. McVey, C.E.; Tolley, S.P.; Done, S.H.; Brannigan, J.A.; Wilson, K.S.. "A new crystal form of penicillin acylase from Escherichia coli". Acta Crystallographica Section D: Biological Crystallography 53 6 (1997): 777-779. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030782436&partnerID=MN8TOARS.
    10.1107/S0907444997006707
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/06/09 KSHV LANA - A Chromatin Modulator SCAN Seminars
ITQB NOVA (Oeiras, Portugal)
2017/07/28 Structural and biochemical analysis of LANA interactions with USP7: Incorporation of a glutamine residue in substrate competition by KSHV LANA 20th International Workshop on Kaposi's Sarcoma Herpes Virus (KSHV) and Related Agents
Conventus Congressmanagement & Marketing GmbH (Berlin, Germany)
2016/03/16 The Pivotal Role of LANA in Kaposi Sarcoma Herpesvirus (KSHV) SCAN Seminars
ITQB NOVA (Oeiras, Portugal)
2014/07/17 Structural and biophysical characterisation of murine NOD2 regulation PCISBIO
ITQB NOVA (Oeiras, Portugal)
2014/02/19 Structural characterization of LANA: Impact on Herpesvirus Latency SCAN Seminars
ITQB NOVA (Oeiras, Portugal)
2012/12/09 Structural Characterization of LANA: Impact on Herpesvirus Latency Harvard-Portugal Annual Retreat
Harvard Medical School – Portugal Program in Translational Research (Lisbon, Portugal)
2010/10/09 Management and Dissemination of Structural Data Fundamentals of Modern Methods of Biocrystallography FEBS Practical and Lecture Course Biocrys 2010 - Fundamentals of Modern Methods of Biocrystallography 9th - 16th October 2010, Oeiras, Portugal
ITQB NOVA (Oeiras, Portugal)
2009/11/19 Cloning and expression in Pichia pastoris - An overview. Advanced Strategies for the Expression of Proteins and Protein Complexes in Yeast
Spine 2-Complexes Teach SG workshop (Barcelona, Spain)
2008/10/11 Preparing Proteins for Crystallization BioCrys 2008 - Fundamentals of Modern Methods of Biocrystallography
FEBS (Oeiras, Portugal)
2008/10/03 The Crystallographic Web of Knowledge Fundamentals of Modern Methods of Biocrystallography FEBS Practical and Lecture Course Biocrys 2008 - Fundamentals of Modern Methods of Biocrystallography
FEBS (Oeiras, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/02/24 - 2024/06/01 Understanding Kaposi's Sarcoma Herpesvirus LANA interactions with chromatin modifiers.
Supervisor of Ana Patrícia Costa Dias
 Biomedical Research (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2024/01/15 - 2024/03/01 (BSc Project) - Herpesvirus LANA interaction with the chromatin adapter Elongin BC.
Supervisor of Sara Agostinho
 Biologia Celular e Molecular (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/07/20 - 2023/09/06 Summer Internship - Herpesvirus LANA interaction with USP7 and Elongin BC 1) Basic introduction to laboratory techniques to study protein interactions. 2) Practical instruction on how to write a lab report.
Supervisor
 Bioquimica (Other)
Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal
2023/07/10 - 2023/09/06 (Summer Internship) - Herpesvirus LANA interaction with USP7 and Elongin BC 1) Basic introduction to laboratory techniques to study protein interactions. 2) Practical instruction on how to write a lab report.
Supervisor
 Biologia Celular e Molecular (Scientific initiation)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2023/06/15 - 2023/08/30 (Summer Internship) - Herpesvirus LANA interaction with USP7 and Elongin BC. 1) Basic introduction to laboratory techniques to study protein interactions and tutorial on how to write a lab report.
Supervisor of Sara Agostinho
 Biologia Celular e Molecular (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2017/09/01 - 2018/11/13 The role of Ubiquitin Specific Protease 7 on Latency associated Nuclear Antigen DNA binding
Supervisor
 MSc in Biochemistry for Health (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/01/18 - 2017/05/14 Role of LANA in the establishment and maintenance of the KSHV epigenome
Supervisor
 Bioquímica (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/01/14 - 2016/06/28 LANA interaction with USP7
Supervisor
 BSc Biochemistry research project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/09/01 - 2015/08/31 Staying under the radar - the multifunctional LANA Protein http://hdl.handle.net/10362/16215
Supervisor of Tânia filipa fernandes santos alves Custódio
 Bioquímica (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/04/01 - 2015/03/31 Structural Virology of the murid Gamma-Herpesvirus 4 (MuHV-4) - Elucidating the roles of viral latency proteins M2 and ORF73
Supervisor
 Doctoral Program in Structural Biology (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/03/01 - 2013 Structural studies on mammalian innate immunity receptors FCT - DFRH - SFRH/BD/65898/2009
Co-supervisor
 Biological Chemistry (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2009/07/15 - 2009/07/16 Part of the organising committee for SPINE2-COMPLEXES Annual meeting from 15th- 16th July, 2009, Lisbon, Portugal. Management and creation of the Meeting and registration website . (2009/07/15 - 2009/07/16)
Conference (Member of the Organising Committee)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/02/10 - 2020/02/10 We recently had a visit from 12th-grade students of Escola Secundária da Moura as part of the "Cientificamente Provável" program, which is a joint initiative by the Ministries of Education and Science, Technology, and Higher Education. This program is designed to promote knowledge and enrich the educational experience of young people by establishing closer links between higher education, research institutions, and basic and secondary schools. It is implemented through the School Libraries Network and our science communication office.
Round table
 Visit Moura High School - What is Research - Ask a Structural Virologist
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/11 PhD Jury - Effects of Wolbachia on transposable element dynamics and on fitness traits in Drosophila melanogaster
President of the jury
 Ana Teresa Mendes Eugénio (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2023/03/21 PhD Jury - The Role of the Periaqueductal Gray in Female Sexual Behaviour.
President of the jury
 Baylor Craig Brangers (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2022/04/27 Atypical culture conditions and process intensification to enhance vaccine production using insect cells
President of the jury
 Ricardo Jorge Carvalho Correia (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/09/20 President of PhD Jury Dissertation presented to obtain the Ph.D degree in Molecular Biosciences
President of the jury
 Ana Lina Pereira Rodrigues (PhD)
Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/07/19 At the crossroad between innate immunity and RNA editing: Structural and biochemical studies of the Za domain family and the RNA editing enzyme ADAR1
(Thesis) Main arguer
 Krzysztof Kus (PhD)
Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/11/21 Phage Display as a Tool for Generation of Biotherapeutic Agents for Breast Cancer
(Thesis) Main arguer
 Andreia Teixeira Ferreira (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/11/15 Human ceruloplasmin and neurotransmitters: complex stabilization and crystallization
(Thesis) Main arguer
 Daniela Mesquita Moutinho (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008/11/21 Structural studies on family III alcohol dehydrogenases from pathogenic bacteria.
Thesis Member
 David Marçal (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019/10/01 - 2023/10/31 PhD committee (Diogo Athayde) - My main role is to guide the decision-making process on the progress of the PhD and execution of the thesis plan. We convened in the first year to approve the initial plan for the thesis and once again to give final approval. Once a year, we meet to evaluate the student's progress and determine if they are making sufficient progress towards their goal.
Member
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2013/09/04 - 2016/08/31 PhD committee (Sofia Cerqueira) - My main role is to guide the decision-making process on the progress of the PhD and execution of the thesis plan. We convened in the first year to approve the initial plan for the thesis and once again to give final approval. Once a year, we met to evaluate the student's progress and determine if they are making sufficient advances towards their goal.
Member
 Instituto de Medicina Molecular, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/03/10 - Current Master of Computational Biology and Bioinformatics - The program of Biomolecular Simulation Biologia Computacional e Bioinformática (Mestrado integrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/09/01 - Current MolBios PhD Program PhD (Curso de doutoramento (conclusão de unidades curriculares)) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/09/01 - 2021/08/31 Viruses MBpS - Functional organization of the cell Master in Biochemistry for Health (Curso de mestrado (conclusão do curso de especialização)) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2022/05/26 The subtle connection between a tumor virus and leukemia - ITQB NOVA researcher's study unravels how herpes oncoviruses are linked with a leukemia related-protein. Kaposi's sarcoma-associated herpesvirus (KSHV) is one of seven currently known human cancer viruses, or oncoviruses, and a leading cause of malignancy in AIDS. KSHV establishes persistent, lifelong infection of its human host and persists latently in tumour cells. In a new study, researchers revealed how virus latency is linked to the Mixed-lineage leukaemia 1 protein. https://www.itqb.unl.pt/news/kshv-imunocompromised
2013/11/18 Interview and newspaper article revealing the structure determination of the DNA binding domain of the LANA protein. Article also highlights the link between KSHV infection and HIV AIDS for public outreach purposes. It highlights how Kaposi¿s sarcoma went from a rare skin cancer, appearing in older men, and affecting certain parts of the globe, to a disease more spread when AIDS emerged. It also highlighted the importance of the viral LANA protein and how the structure was solved by the X-ray crystallography technique. Publico newspaper
2009/11/18 The Prémio Câmara Pestana 2008 was attributed to the research work "Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex" published in Nature (2006) by ITQB researchers, Carlos Frazão, Colin E. McVey, Mónica Amblar, Ana Barbas, Cecília M. Arraiano and Maria A. Carrondo. This is the second year in a row that this scientific award is attributed to research work produced at ITQB. https://www.rostos.pt/inicio2.asp?cronica=71738&mostra=2&seccao=as-

Mentoring / Tutoring

Topic Student name
2018/08/01 - 2018/10/31 Understanding the Interactions of the KSHV LANA protein Sara Castelli - Erasmus Traineeship Program
2012/04/01 - 2015/11/30 Training and Mentoring of a Post-Doctoral Fellow Rajesh Ponnusamy
2014/02/01 - 2015/09/30 Training and mentoring of Research assistant. Ana Sofia Ferreira-Ramos
2011/12/01 - 2014/01/31 Training and mentoring of Research assistant. Sara Loureiro Brandão
2005/07/01 - 2008/07/31 Training and mentoring of Post-doctoral Research assistant. Daniele de Sanctis
2006/09/01 - 2007/09/30 Training and mentoring of a Research assistant. Miguel Lopes
Distinctions

Other distinction

2008 Prémio Câmara Pestana 2008
Instituto Camara Pestana, Portugal

Glaxo Wellcome Farmaceutica Lda, Portugal
2007 Medalha Municipal de Mérito - Grau Ouro
Camara Municipal Oeiras, Portugal
1997 Awarded the Shell Postgraduate Chemistry Research Poster Prize.