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Ana Teresa Rajado is currently a research fellow at Algarve Biomedical Center - Research Institute (ABC-Ri). Her main research interests are gene therapy, epigenetics, neurodegenerative disorders, aging, and computational biology. Within these fields, she developed 3 internships (molecular biology (160 hours, 2016), microbiology (40 hours, 2017) and neurosciences and gene therapies (400 hours, 2021)). She published a review paper as first author (Aging, 2023), and is co-author of 3 other reviews (Mechanisms of Ageing and Development, 2023; Biogerontology, 2023 and npj Aging, 2023) and of a research paper (Cell Reports, 2021). Additionally, she presented 2 posters (EMBO workshop, 2023, Alexandoupoli - Greece & ABC-Days, 2022, Sagres - Portugal) and did 2 post-graduate courses, one on Computational Biology and the other on Experimental Approaches to Biomedicine (20/20). Ana Teresa obtained her bachelor's degree in Biology in 2018 at University of Coimbra. During this degree she was part of the ERASMUS+ program, having studied at the University of Oslo during the Autumn semester of 2017-2018. Afterwards, she obtained her master's degree (MSc) in Biochemistry (2020) by the University of Coimbra. Her MSc thesis was developed at UC-Biotec, within the Rational Protein Engineering research group led by Dr Alexandra Carvalho. In this work, Molecular Modelling, Molecular Mechanics, as well as Molecular Dynamics tools were used to induce (and analyse) mutations on a genome editing enzyme (Cas12a, of the CRISPR-Cas system) amino acid sequence, in silico, to increase the interactions between the protein and its target nucleic acids and prevent potential off-target effects. This work led to her enrolling in advanced courses to develop computational skills on a broad range of bioinformatical tools, having given a hands-on lecture of Computational Biology. Afterwards, she volunteered as an intern at Algarve Biomedical Center - Research Institute (2021), within the Molecular Neuroscience and Gene Therapy research group led by Prof. Clévio Nóbrega, studying neurodegenerative disorders and particularly Spinocerebellar Ataxias type 2 and 3. During this internship, she acquired hands-on experience with several molecular biology techniques, animal behavior testing and cell culture. Afterwards, she joined the ALFA Score project at ABC-Ri as a research fellow, in January 2022, under the supervision of Prof. Pedro Castelo-Branco, who leads the research group Epigenetics and Human Disease. This project focused on the development of an algorithm to integrate multi-omics data with epigenetics, biochemical parameters and demographics to unravel patterns of healthy aging in the region of Algarve. Within the ALFA Score project, she acquired skills on epigenetics analysis, particularly regarding DNA methylation. Currently, she is a research fellow within the project AdvGT-CSB - "Advancing the development of a gene therapy for Cockayne Syndrome type B" - at the Molecular Neuroscience and Gene Therapy Lab, supervised by Prof. Clévio Nóbrega, on ABC-RI.
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Identificação

Identificação pessoal

Nome completo
Ana Teresa Rajado

Nomes de citação

  • Rajado, Ana Teresa
  • Rajado, A. T.

Identificadores de autor

Ciência ID
211E-A1B0-AC5E

Endereços de correio eletrónico

  • anateresa.rajado@abcmedicalg.pt (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A2)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2024/01/09 - 2025/01/09
Em curso
 Metodologia E Comunicação Científica Avançada (Pós-Graduação)
Especialização em Comunicação Científica
Universidade do Algarve - Campus de Gambelas, Portugal
2022/01 - 2022/12/31
Concluído
 Abordagens Experimentais em Biomedicina (Pós-Graduação)
Especialização em Biomedicina
Universidade do Algarve - Campus de Gambelas, Portugal
 20
2022/10/26 - 2022/10/27
Concluído
 Advanced Training - Tidy Data Visualisation with R (Outros)
Especialização em Computational Biology
Centro de Ciências do Mar, Portugal
2021/09 - 2021/12
Concluído
 Internship (Outros)
Especialização em Biomedicine
Algarve Biomedical Center - Research Institute, Portugal
2021/02 - 2021/07
Concluído
 German A1 (Outros)
Especialização em Languages
Instituto Politécnico de Coimbra Escola Superior de Educação de Coimbra, Portugal
 19
2021/05/24 - 2021/05/28
Concluído
 The CRISPR Revolution Workshop (Outros)
Especialização em Biomedicine
Algarve Biomedical Center - Research Institute, Portugal
2018/09 - 2020/11/10
Concluído
 Bioquímica (Mestrado)
Especialização em Biologia Computacional - Engenharia de Proteínas
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
"Computation meets experimentation to improve the catalysis and specificity of Cas12a genome editing enzyme" (TESE/DISSERTAÇÃO)
 17
2020/08/07 - 2020/11/07
Concluído
 Curso Não Conferente de Grau de Biologia Computacional (Outros)
Especialização em Biologia Computacional
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 APMB
2015/09 - 2018/06
Concluído
 Biologia (Licenciatura)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
 14
2017/08/10 - 2017/12/20
Concluído
 ERASMUS+ (Outros)
Especialização em Biosciences
Universitetet i Oslo, Noruega
2017/03 - 2017/05
Concluído
 Internship (Outros)
Especialização em Microbiology
Universidade de Coimbra Centre for Functional Ecology - Science for People & the Planet, Portugal
2016/07 - 2016/08
Concluído
 Summer Internship (Outros)
Especialização em Neuroscience
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/01/01 - Atual Investigador (Investigação) Algarve Biomedical Center - Research Institute, Portugal
Algarve Biomedical Center - Research Institute, Portugal
2022/01/01 - 2023/12/31 Investigador (Investigação) Universidade do Algarve Algarve Biomedical Center, Portugal
Universidade do Algarve Algarve Biomedical Center, Portugal
2020/08/07 - 2020/11/07 Estagiário de Investigação (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/02 - 2021/06 Recenseadora - Censos 2021 Instituto Nacional de Estatistica, Portugal
Instituto Nacional de Estatistica, Portugal
Projetos

Projeto

Designação Financiadores
2024/01/01 - 2024/09/30 AdvGT-CSB: Advancing the development of a gene therapy for Cockayne Syndrome type B
AdvGT-CSB
Bolseiro de Investigação
Algarve Biomedical Center Research Institute, Portugal
Em curso
2022/01/01 - 2023/12/31 ALFA Score - ALgarve Fit Aging Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável
ALG-01-0145-FEDER-072586
Bolseiro de Investigação
Algarve Biomedical Center - Research Institute, Portugal
Concluído
Produções

Publicações

Artigo em revista
  1. Brito, D. V. C.; Esteves, F.; Rajado, Ana Teresa; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. Autor correspondente: Nóbrega, C.. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging 9 1 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    Publicado • 10.1038/s41514-023-00120-6
  2. Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; Araújo, Inês; et al. Autor correspondente: Bragança, José. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854. http://dx.doi.org/10.1016/j.mad.2023.111854.
    10.1016/j.mad.2023.111854
  3. Silva, Nádia; Rajado, Ana Teresa; Esteves, Filipa; Brito, David; Apolónio, Joana; Roberto, Vânia Palma; Binnie, Alexandra; et al. Autor correspondente: Castelo-Branco, Pedro. "Measuring healthy ageing: current and future tools". Biogerontology (2023): http://dx.doi.org/10.1007/s10522-023-10041-2.
    10.1007/s10522-023-10041-2
  4. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David V.C.; ALFA Score Consortium; Binnie, Alexandra; Araújo, Inês Maria; et al. Autor correspondente: Pedro Castelo-Branco. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging 15 8 (2023): 3191-3217.
    Acesso aberto • Publicado • 10.18632/aging.204668
  5. Ramos, Helena; Soares, Maria I.L.; Silva, Joana; Raimundo, Liliana; Calheiros, Juliana; Gomes, Célia; Reis, Flávio; et al. Autor correspondente: Saraiva, Lucília. "A selective p53 activator and anticancer agent to improve colorectal cancer therapy". Cell Reports 35 2 (2021): 108982. http://dx.doi.org/10.1016/j.celrep.2021.108982.
    Publicado • 10.1016/j.celrep.2021.108982
Poster em conferência
  1. Ramos, Mónica; Santos, Daniela F.; Rajado, Ana Teresa; ALFA Score Consortium; Silva, Nádia; Araújo, Inês; Pedro Castelo-Branco. Autor correspondente: Pedro Castelo-Branco. "Associations between a DNA methylation-based telomere length estimator, the redox state, diet and aging in the Algarve population". Trabalho apresentado em IX Clinical Biochemistry Workshop, 2024.
  2. Matos, José; Castelo-Branco, Pedro; Silva, Nádia; Rajado, A. T.; Faleiro, Maria Leonor. Autor correspondente: Faleiro, Maria Leonor. "Gut Bacterial Metataxonomic Analysis of Elderly from Algarve". Trabalho apresentado em CONGRESS OF MICROBIOLOGY AND BIOTECHNOLOGY 2023, MICROTIOTEC23, 2023.
  3. Apolónio, Joana ; Silva, Nádia; Rajado, Ana Teresa; Brito, David; Esteves, Filipa; Clévio Nóbrega; Araújo, Inês; et al. Autor correspondente: Pedro Castelo-Branco. "ALFA Score - Algarve Fit Ageing Score Project, a multidisciplinary approach for ageing assessment". Trabalho apresentado em 19th Congress of the European Geriatric Medicine Society, 2023.
    https://doi.org/10.1007/s41999-023-00883-x
  4. Rajado, Ana Teresa; Pestana, Daniel; Silva, Nádia; Apolónio, Joana ; Esteves, Filipa; Brito, David V.C.; Trindade, Marlene; et al. Autor correspondente: Pedro Castelo-Branco. "Algarve Fit Ageing Score Project, A Multidisciplinary Approach To Assess Healthy Ageing Status". Trabalho apresentado em EMBO Workshop - Systems Biology: Linking chromatin and Epigenetics to Disease and Development, 2023.
  5. Marcelo, Adriana; Afonso, Inês T.; Rajado, Ana Teresa; Rafael G. Costa; Afonso-Reis, Ricardo; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues . Autor correspondente: Nóbrega, Clévio David Rodrigues. "Tackling Machado-Joseph disease through stress granules: is protein CARHSP1 a potential target for therapeutics?". Trabalho apresentado em FENS Regional Meeting 2023, 2023.
  6. Marcelo, Adriana; Afonso, Inês T.; Rajado, Ana Teresa; Rafael G. Costa; Afonso-Reis, Ricardo; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues . Autor correspondente: Nóbrega, Clévio David Rodrigues. "Stress granule protein CARHSP1 as a potential therapeutic strategy for MJD". Trabalho apresentado em ENCODS 2023, 2023.
  7. Marcelo, Adriana; Afonso, Inês T.; Rajado, Ana Teresa; Costa, Rafael G; Afonso-Reis, Ricardo; de Almeida, Luís Pereira; Nóbrega, Clévio David Rodrigues. "Modulation of stress granules components as a therapeutic approach for spinocerebellar ataxia type 3". Trabalho apresentado em V Encontro Anual do Algarve Biomedical Center, 2022.
  8. Rajado, Ana Teresa; Raquel P. Andrade; Apolónio, Joana ; Inês Maria Pombinho de Araújo; Brito, David V.C.; Sofia M. Calado; Esteves, Filipa; et al. "ALFA Score - Algarve Fit Ageing Score". Trabalho apresentado em ABC-Days, 2022.
  9. Koppenol, Rebekah; Conceição, André; Afonso, Inês T.; Rajado, Ana Teresa; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Generation of a novel transgenic mouse model of spinocerebellar ataxia type 2 expressing mutant ATXN2 in cerebellar Purkinge cells". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
Tese / Dissertação
  1. "Computation Meets Experimentation to Improve the Catalysis and Specificity of Cas12a Genome Editing Enzyme". Mestrado, Universidade de Coimbra, 2020.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/05/26 Algarve Fit Ageing Score Project, A Multidisciplinary Approach to Assess Healthy Ageing Status EMBO Workshop - Linking chromatin and epigenetics to disease and development
EMBO - Democritus University of Thrace, GR (Alexandroupoli, Grécia)
2022/10/14 ALFA Score - Algarve Fit Ageing Score ABC Days
Algarve Biomedical Center - Research Institute (Sagres, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2024/03/17 - 2024/03/17 Marcha Pelas Ataxias - Caminhada solidária de sensibilização sobre doenças do movimento, em particular sobre a Ataxia Espinocerebelosa do Tipo 2 e sobre a Ataxia Espinocerebelosa do Tipo 3. O valor angariado reverteu para a Associação Atlântica de Apoio aos Doentes de Machado Joseph e para a Associação Portuguesa de Ataxias Hereditárias. (2024/03/17 - 2024/03/17)
Outro (Membro da Comissão Organizadora)
 Algarve Biomedical Center Research Institute, Portugal
2023/10/23 - 2023/10/23 Mama em Movimento - Marcha/Corrida Solidária - 2ª Edição. Objetivo: obtenção de donativos decorrentes das inscrições, que serão entregues à Associação Oncológica do Algarve e à Liga Portuguesa Contra o Cancro com o intuito de apoiar e promover de atividades relacionadas com a prevenção e investigação em cancro da mama. (2023/10/23 - 2023/10/23)
Outro (Membro da Comissão Organizadora)
 Universidade do Algarve Algarve Biomedical Center, Portugal
2023/05/03 - 2023/05/05 FENS Regional Meeting 2023 - I was volunteer at this event. This enabled me not only to help the participants to have the best experience possible, but also allowed me to closely contact with amazing researchers who are pioneers in their neuroscience fields. (2023/05/03 - 2023/05/05)
Conferência (Outra)
 Algarve Biomedical Center - Research Institute, Portugal
2022/10/23 - 2022/10/23 Mama em Movimento - Marcha/Corrida Solidária. Objetivo: obtenção de donativos decorrentes das inscrições, que serão entregues à Associação Oncológica do Algarve com o intuito de apoiar e promover de atividades relacionadas com a prevenção e investigação em cancro da mama. (2022/10/23 - 2022/10/23)
Outro (Membro da Comissão Organizadora)
 Algarve Biomedical Center - Research Institute, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023/07/12 - 2023/07/13 Oncobiology Workshop, by Mahmoud A. Alfagih
Oficina (workshop)
 Oncobiology Workshop, by Mahmoud A. Alfagih
Algarve Biomedical Center - Research Institute, Portugal
2022/12/06 - 2022/12/07 International Conference "Aging Without Borders". Topic such as healthy aging, age-associated disroders (particularly neurodegenerative disorders) and strategies to study aging (for example through induced pluripotent stem cells and microbiome studies) were approached.
Congresso
 Ageing Without Borders
Algarve Biomedical Center - Research Institute, Portugal
2022/11/22 - 2022/11/22 Participation in a "Basic Life Support and Automatic External Defibrillator" course (7hours).
Outro
Algarve Biomedical Center - Research Institute, Portugal
2022/11/08 - 2022/11/08 Participation in the Algarve Biomedical Center - Research Institute Fall International Forum titled "Tackling the Burden of RARE diseases" - Algarve
Outro
 Fall International Forum
Algarve Biomedical Center - Research Institute, Portugal
2022/10/15 - 2022/10/15 Participation in the international science fair "FIC.A". Presentation of several activities developed within Algarve Biomedical Center - Research Institute - Oeiras.
Festival
 Festival Internacional de Ciência (FIC.A)
2022/04/12 - 2022/04/12 Participation in the Algarve Biomedical Center - Research Institute Spring International Forum titled "Gene and Cell Therapies for Healthy Ageing" - Algarve.
Outro
 Spring International Forum
Algarve Biomedical Center - Research Institute, Portugal
2022 - 2022 9 hours Online Course "Healthy Ageing: Concepts, interventions and Preparing for the Future", by University of Birmingham - FutureLearn Platform. This online course explored perceptions and experiences of healthy ageing, frailty, physical activity guidelines, debunked myths surrounding nutrition in older age, applied different research methodologies to extending healthspan via lifestyle interventions, and looked at preparing for the future.
Outro
 Online Course "Healthy Ageing: Concepts, interventions and Preparing for the Future"
University of Birmingham Birmingham Medical School, Reino Unido
2021/03/18 - 2021/03/21 Participation in the AIMS Meeting, promoted by the students association of the Faculty of Medicine of the University of Lisbon. I joined the workshops "Neurodevelopmental Disorders" and "Cancer Immunotherapy: Upgrade your Defenses".
Conferência
 AIMS Meeting
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 - 2021 Postgraduate-level online course (15 hours). It explored how genomic technologies (molecular genetic and cytogenetic techniques) are used in healthcare to investigate genetic disorders.
Outro
 Genomic Technologies in Clinical Diagnostics: Molecular Techniques
St George's Hospital Medical School, Reino Unido
2021 - 2021 Participation in the seminar "Emerging Gene Therapies for the Brain", by Beverly Davidson - Coimbra.
Seminário
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021 - 2021 Participation in the webinar "Gene Therapy and Genome Editing using Recombinant AAV vectors", by Nature.
Seminário
2021 - 2021 4 hours Online Course "Computer Programming for Everyone" by University of Leeds and Institute of Coding - FutureLearn Platform. This course presented computer programming and the problems it can be an answer to, the different coding languages and fundamental coding principles.
Outro
 Computer Programming for Everyone
University of Leeds School of Computing, Reino Unido
2021 - 2021 15 hours Online Course "Genomic Technologies in Clinical Diagnostics: Molecular Techniques" by St George's, University of London - FutureLearn Platform. This was a postgraduate level course that explored how genomic technologies (molecular genetic and cytogenetic techniques) are used in healthcare to investigate genetic disorders
Outro
 Online Course "Genomic Technologies in Clinical Diagnostics: Molecular Techniques"
St George's Hospital Medical School, Reino Unido
2021 - 2021 12 hours Online Course "Food as Medicine" by Monash University - FutureLearn Platform. This course explored the different types of food and how it can influence the treatment and prevention of disease.
Outro
 Food as Medicine
Monash University, Austrália
2021 - 2021 8 hours Online Course "Interdisciplinary Learning: Working Across Disciplines", by University of Leeds - Future Learn Platform. This course explored interdisciplinary learning applied to study and research projects. It focused on communication techniques, teamwork and planning encompassing the different disciplines and expertises that will contribute to the project.
Outro
 Interdisciplinary Learning: Working Across Disciplines
University of Leeds Institute of Communications Studies, Reino Unido
2020/08 - 2020/09 40 hours Online Course "Project Management" by FormaçaOnline.
Outro
 Project Management
2020 - 2020 Participation in the masterclass "A cell culture master class: What your cells wish they could tell you", by Science.
Outro
2019 - 2019 Participation in the seminar "The CRISPR revolution", by Chase Beisel - Coimbra.
Seminário
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019 - 2019 Microbiotec, a microbiology and biotecnology conference.
Encontro
 Microbiotec
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/04 - 2018/04 Attendance to the World Health Summit - Regional Meeting - Coimbra
Conferência
 World Health Summit - Regional Meeting
2018/03 - 2018/03 Participation in the XXI Nacional Meeting of Biology Students - Lisbon. Participation in an animal experimentation workshop.
Encontro
 Encontro Nacional de Estudantes de Biologia
2017/04 - 2017/04 Attendance to the "8th Symposium of Bioengineering" (18 hours), in Porto
Simpósio
 8th Symposium of Bioengineering
2016/07 - 2016/07 Participation in the XL Jornadas Portuguesas de Genética - Coimbra
Conferência
 XL Jornadas Portuguesas de Genética
2016/03 - 2016/03 Participation in the XIX Nacional Meeting of Biology Students - Coimbra. Participation in a science communication workshop.
Encontro
 Encontro Nacional de Estudantes de Biologia
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/02/27 - Atual Lecturer of the hands-on session "Molecular Dynamics" on the "Computational Biology" course of the PhD Program "Experimental Biology and Biomedicine" of University of Coimbra. Experimental Biology and Biomedicine (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2019/01 - 2019/04 Buddy of the program SPEAK. I taught conversational portuguese to a class of imigrants from 6 different nationalities. Conversational Portuguese (Outros)

Membro de associação

Nome da associação Tipo de participação
2016 - 2021 Orquestra Académica da Universidade de Coimbra Member
2015 - 2021 Tuna Académica da Universidade de Coimbra (TAUC). Member of TAUC's direction during the lective year of 2016-2017. Member
2016 - 2018 Núcleo de Estudantes de Biologia. Member of the Profissional Opportunities division during the lective year of 2016-2017, and member of the International Relationships division during 2017-2018. Member