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Joana Apolónio has a PhD in Mechanisms of Disease and Regenerative Medicine completed in 2019. During her PhD project she worked under the supervision of Dr. Pedro Castelo-Branco (UAlg) and Dr. Uri Tabori (Hospital for Sick Children, Toronto, Canada), and she was focused on the study of TERT promoter methylation status in breast cancer, namely, its impact on TERT transcriptional regulation and its clinical implications, as a disease biomarker and therapeutic target. Since 2020, holds a position as Auxiliar Researcher at the Algarve Biomedical Center/ Algarve Biomedical Center Research Institute (ABC-RI), where integrates the Epigenetics in Human Disease Group, coordinated by Dr. Pedro Castelo-Branco, and is the head of the Strategic Planning and Project Management Unit of ABC. Since 2022, she integrated the ABC CoLab team and holds a position as Invited Auxiliar Professor at the Faculty of Medicine and Biomedical Sciences, University of Algarve, where teaches units like Epigenetics and Problem-Based-Learning (PBL-clinical within the Master's Degree in Medicine). Through her academic path in cancer research, became highly experienced in a wide repertoire of cellular and molecular biology techniques. Has also excellent communication and team working skills coupled with personal qualities including competence, responsibility, dynamism, and with a strong commitment to high ethical standards. In the last years has been focused on the study of epigenetic alterations in cancer, including breast, colorectal, prostate, bladder and gliobastoma, and also in ageing. She has been deeply committed to attracting funding. Joana has participated in 13 research projects (both national and international), 1 as Principal Investigator (PI), and 12 as team member. As a result of her scientific career, published 18 articles in international journals with peer-review, resulting in more than 700 citations, with an h-index of 11 (according to Scopus). Her work was also presented in national and international meetings, counting with 12 oral communications and 25 poster presentations. Additionally, she received a total of 7 distinctions awards and/or honors. In 2025, she was awarded with a grant from the Portuguese League Against Cancer-NRS to further investigate THOR methylation as a non-invasive biomarker in breast cancer. Is highly engaged in supervising students conducting laboratory works with a total of 10 students in the last years: 1 PhD student in Biomedical Sciences (ongoing), 1 MSc in Medicine, 1 Biomedical Sciences monography and 7 Medicine monographs (1 ongoing). She was also a jury member and arguer of 1 academic MSc degree and 1 Bachelor's degree. Joana has also organized several meetings/events and is highly involved in several outreach and science communication activities. Additionally, Joana still collaborates with Dr. Uri Tabori (Hospital for Sick Children, Toronto, Canada) and has many collaborations with clinicians at the Algarve Local Health Unit, Faro. CAREER BREAKS/MATERNAL LEAVE (1): September 2020/February 2021 (reduced working hours until September 2021).
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Identificação

Identificação pessoal

Nome completo
Joana Dias Apolónio Viegas

Nomes de citação

  • Apolónio, Joana

Identificadores de autor

Ciência ID
791E-9E39-2795
ORCID iD
0000-0002-9727-1813

Endereços de correio eletrónico

  • joanadias_a@hotmail.com (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Médicas e da Saúde - Medicina Clínica - Oncologia
  • Ciências Médicas e da Saúde - Medicina Clínica
  • Ciências Naturais - Ciências Biológicas - Microbiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1)
Formação
Grau Classificação
2015/01/05 - 2019/10/29
Concluído
 Mechanisms of Disease and Regenerative Medicine (Doutoramento)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
"TERT Hypermethylated Oncologic Region (THOR) as a Biomarker for Breast Cancer." (TESE/DISSERTAÇÃO)
 Approved with High Distinction and Honor
2018/02/01 - 2018/03/31
Concluído
 Observership in Breast Cancer Clinical Practice (Outros)
Odette Cancer Centre, Canadá

Sunnybrook Health Sciences Centre, Canadá
2017/02/23 - 2017/02/23
Concluído
 Workshop - Gene Delivery for Biomedical application. (Outros)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2016/12/08 - 2016/12/10
Concluído
 Animal Experimentation Course (Category B, 42 hours, accreditation from FELASA) (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório (SPCAL) , Portugal
2015/05/11 - 2015/05/14
Concluído
 V Workshop on Cancer Research: Biological and molecular basis. (Outros)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 18 (in a scale from 0 to 20)
2014/04/28 - 2014/05/28
Concluído
 Pedagogical Aptitude Training course (CCP) (Outros)
Instituto do Emprego e Formação Profissional, Portugal
 Excellent
2011/10/05 - 2013/12/16
Concluído
 Master in Biomedical Sciences (Mestrado)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
"Acquisition of tolerance to essential oil components by pathogenic bacteria." (TESE/DISSERTAÇÃO)
 19 (in a scale from 0 to 20)
2007/09/24 - 2011/06/16
Concluído
 Degree in Biomedical Laboratory Sciences (Licenciatura)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
"Influence of obesity on lipid profile of patients with type II diabetes mellitus." (TESE/DISSERTAÇÃO)
 17 (in a scale from 0 to 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/07/29 - Atual Investigador (Investigação) Laboratório Colaborativo do Algarve Biomedical Center, Soluções Integradas para o Envelhecimento e Rejuvenescimento (ABC CoLAB), Portugal
2020/01/15 - Atual Gestão de Ciência e Tecnologia Algarve Biomedical Center, Portugal
Algarve Biomedical Center, Portugal
(...)
2020/01/15 - Atual Investigador Auxiliar (carreira) (Investigação) Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
Universidade do Algarve, Portugal
(...)
2014/01/15 - 2014/04/15 Investigador (Investigação) Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/01/01 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2021/03/01 - 2022/09/30 Assistente convidado (Docente Ensino Superior Politécnico) Universidade do Algarve Escola Superior de Saúde, Portugal

Outras Carreiras

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/10/10 - 2014/12/31 Técnico Principal (Técnico de Diagnóstico e Terapêutica - Técnico de Análises Clínicas e de Saúde Pública) SYNLAB Portugal, Portugal
SYNLAB Portugal, Portugal
2011/09/01 - 2012/06/30 Técnico Principal (Técnico de Diagnóstico e Terapêutica - Técnico de Análises Clínicas e de Saúde Pública) Laboratório de Análises Clínicas A. Reis Valle, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/05 - 2019/10/29 PhD student Universidade do Algarve, Portugal
2012/09/01 - 2013/12/16 Master student Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Projetos

Bolsa

Designação Financiadores
2023/01/01 - Atual Strategic Plan of the Algarve Biomedical Center
CAC/0007/2022
Investigador
Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2025/03/01 - 2027/02/28 hTERT promoter methylation as a biomarker for breast cancer detection in the blood.
Bolsa de Investigação em Oncologia LPCC-NRS 2025
Investigador responsável
Algarve Biomedical Center, Portugal

Algarve Biomedical Center Research Institute, Portugal
Liga Portuguesa Contra o Cancro
Em curso
2023/06/14 - 2024/01/14 Equity in health for LGBTQIA+ people
Grant Agreement no. 101058677
Investigador
European Commission
2022/04/01 - 2023/12/31 PtCRIN - Portuguese Clinical Research Infrastructure network - Development of the Advanced Clinical Research Center and clinical trial management in the Algarve
ALG-01-0145-FEDER-072680
Investigador
2021/04/01 - 2023/12/31 PtCAC Portuguese Network of Clinical Academic Centers: Center of Research Excellence of the Academic Center for Biomedical Research and Training in the Algarve (CRE-ABC)
ALG-01-0145-FEDER-072682
Investigador
2021/01/01 - 2023/12/31 ALFA Score - ALgarve Fit Ageing Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável
ALG-01-0145-FEDER- 072586
Investigador
Concluído
2015 - 2020 Targeting the telomere maintenance pathway for cancer diagnostics and therapeutics.
Canadian Cancer Society Impact Grants
Bolseiro de Doutoramento
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

University of Toronto Faculty of Medicine, Canadá

Hospital for Sick Children, Canadá
Canadian Cancer Society
Em curso
2015 - 2020 Novel implications of THOR hypermethylation in telomere maintenance and gliomagenesis.
Early Renewal-Canadian Institutes of Health Research
Bolseiro de Doutoramento
Hospital for Sick Children, Canadá

Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
Canadian Institutes of Health Research
Em curso
2015/01/01 - 2019/10/29 Tert Hypermethylated Oncologic Region (THOR) as a biomarker for Breast Cancer.
PD/BD/105899/2014
Bolseiro de Doutoramento
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015/01 - 2019/10 Tert Hypermethylated Oncologic Region (THOR) as a biomarker for Breast Cancer.
PD/BD/105899/2014
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2018 - 2019 Xenografting of bovine ovarian tissue as a model for testing new drugs and examining angiogenesis, follicle premature depletion and dynamics.
Grant CIISA
Investigador
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal
Concluído
2015/01/05 - 2017/01/14 Diagnostic, prognostic and therapeutic implications of THOR - Tert Hypermethylated Oncologic Region in breast cancer.
Maratona da Saúde
Bolseiro de Doutoramento
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
 Maratona da Saúde Association

Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2017 Utilization of THOR hypermethylation for stratification and noninvasive detection of cancer.
Innovation grant Canadian Cancer Research Society
Bolseiro de Doutoramento
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Hospital for Sick Children, Canadá
Canadian Cancer Society Research Institute
Concluído
2012/05/15 - 2013/12/16 Acquisition of tolerance to essential oil components by pathogenic bacteria.
Pest-OE/EQB/LA0023/2013
Bolseiro de Mestrado
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2025/01/02 - 2026/12/31 ABA: Algarve Brain Aging Imaging Study: Estudo imagiológico do envelhecimento cerebral na população do Algarve
ALGARVE-FEDER-01343800
Investigador
Algarve Biomedical Center, Portugal
Em curso
2024/01/01 - 2026/12/31 NUMAPLUS. Más Allá del Nuevo Modelo Asistencial: Regiones Cardio aseguradas.
0237_NUMAPLUS_5_E
Investigador
Algarve Biomedical Center, Portugal
Em curso
2023/02/01 - 2024/07/31 ExCITinG - Exploring CITED2 role in glioblastoma stem cell biology
2022.09209.PTDC
10.54499/2022.09209.PTDC
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2020/03/31 Centre for Biomedical Research
UID/BIM/04773/2019
Universidade do Algarve, Portugal

Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2020/04/02 - 2022/09/30 Centro de Testes à COVID-19 no Algarve: Sistema "Drive-Thru" e Rastreio em Lares de Idosos.
Sistema "Drive-Thru" e Rastreio em Lares de Idosos.
Investigador
Algarve Biomedical Center, Portugal
Em curso
Produções

Publicações

Artigo em revista
  1. Paiva-Correia, António; Hellquist, Henrik; Apolónio, Joana ; Castelo-Branco, Pedro. "Role of Ancillary Techniques in the Differential Diagnosis of Salivary Gland Carcinomas". APMIS 133 2 (2025): https://doi.org/10.1111/apm.70008.
    Publicado • 10.1111/apm.70008
  2. Esteves, Filipa; Pedro Castelo-Branco; Apolónio, Joana. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research.". Stem Cell Research Vol 81 (2024):
    Publicado
  3. Nádia Silva; Ana Teresa Rajado; Filipa Esteves; David Brito; Joana Apolónio; Vânia Palma Roberto; Alexandra Binnie; et al. "Measuring healthy ageing: current and future tools". Biogerontology (2023): https://doi.org/10.1007/s10522-023-10041-2.
    10.1007/s10522-023-10041-2
  4. Nunes, Francisca Martins; Apolónio, Joana Dias; Mota-Pinto, Anabela; Leão, Ricardo. "Epigenetic alterations in urothelial bladder cancer associated with disease outcomes". International Journal of Urology (2023): http://dx.doi.org/10.1111/iju.15335.
    Publicado • 10.1111/iju.15335
  5. Brito, D. V. C.; Esteves, F.; Rajado, A. T.; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging 9 1 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    10.1038/s41514-023-00120-6
  6. Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; Araújo, Inês; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854. http://dx.doi.org/10.1016/j.mad.2023.111854.
    Publicado • 10.1016/j.mad.2023.111854
  7. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; Araújo, Inês M.; Nóbrega, Clévio; et al. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging (2023): https://doi.org/10.18632/aging.204668.
    Publicado • 10.18632/aging.204668
  8. Apolónio, Joana Dias; Dias, João S.; Fernandes, Mónica Teotónio; Komosa, Martin; Lipman, Tatiana; Zhang, Cindy H.; Leão, Ricardo; et al. "THOR is a targetable epigenetic biomarker with clinical implications in breast cancer". Clinical Epigenetics 14 1 (2022): http://dx.doi.org/10.1186/s13148-022-01396-3.
    10.1186/s13148-022-01396-3
  9. Pimenta, Jorge M.B.G.A.; Pires, Virgínia M.R.; Nolasco, Sofia; Castelo-Branco, Pedro; Marques, Carla C.; Apolónio, Joana; Azevedo, Rita; et al. "Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis". Biochemical and Biophysical Research Communications 598 (2022): 95-99. http://dx.doi.org/10.1016/j.bbrc.2022.02.012.
    10.1016/j.bbrc.2022.02.012
  10. Donghyun D. Lee; Martin Komosa; Sumedha Sudhaman; Ricardo Leão; Cindy H. Zhang; Joana D. Apolonio; Thomas Hermanns; et al. "Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer". Journal of Clinical Investigation (2021): https://doi.org/10.1172/JCI146915.
    10.1172/JCI146915
  11. Bernardo P. de Almeida; Joana Dias Apolónio; Alexandra Binnie; Pedro Castelo-Branco. "Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers". BMC Cancer 19 1 (2019): https://doi.org/10.1186/s12885-019-5403-0.
    Publicado • 10.1186/s12885-019-5403-0
  12. De Mello, Ramon Andrade; Faleiro, Inês; Apolónio, Joana D; Tabori, Uri; Price, Aryeh J; Roberto, Vânia P; Castelo-Branco, Pedro. "Hot topics in epigenetic regulation of cancer self-renewal for pancreatic tumors: future trends". Future Oncology 15 7 (2019): 683-685. http://dx.doi.org/10.2217/fon-2018-0153.
    Publicado • 10.2217/fon-2018-0153
  13. Leão, Ricardo; Lee, Donghyun; Figueiredo, Arnaldo; Hermanns, Thomas; Komosa, Martin; Zhang, Cindy; Lipman, Tatiana; et al. "Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer". International Journal of Cancer 144 7 (2018): 1676-1684. http://dx.doi.org/10.1002/ijc.31935.
    Publicado • 10.1002/ijc.31935
  14. Lee, Donghyun D.; Leão, Ricardo; Komosa, Martin; Gallo, Marco; Zhang, Cindy H.; Lipman, Tatiana; Apolónio, Joana D.; et al. "DNA hypermethylation within TERT promoter upregulates TERT expression in cancer". Journal of Clinical Investigation 129 1 (2018): 223-229. http://dx.doi.org/10.1172/jci121303.
    Publicado • 10.1172/jci121303
  15. Leão, Ricardo; Apolónio, Joana Dias; Lee, Donghyun; Figueiredo, Arnaldo; Tabori, Uri; Castelo-Branco, Pedro. "Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer". Journal of Biomedical Science 25 1 (2018): http://dx.doi.org/10.1186/s12929-018-0422-8.
    Publicado • 10.1186/s12929-018-0422-8
  16. Faleiro, Inês; Apolónio, Joana Dias; Price, Aryeh J; De Mello, Ramon Andrade; Roberto, Vânia Palma; Tabori, Uri; Castelo-Branco, Pedro. "The TERT hypermethylated oncologic region predicts recurrence and survival in pancreatic cancer". Future Oncology 13 23 (2017): 2045-2051. http://dx.doi.org/10.2217/fon-2017-0167.
    Publicado • 10.2217/fon-2017-0167
  17. Apolónio, Joana Dias; Pedro Castelo-Branco; Ricardo Leão; Tatiana Lipman; Brittany Campbell; Donghyun Lee; Cindy Zhang; Uri Tabori. "A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study.". Oncotarget 7 36 (2016): 57726-57736. https://doi.org/10.18632/oncotarget.10639.
    Publicado • 10.18632/oncotarget.10639
  18. Apolónio, Joana Dias; Maria Leonor Faleiro; Maria Graça Miguel; Luis Neto. "No induction of antimicrobial resistance in Staphylococcus aureus and Listeria monocytogenes during continuous exposure to eugenol and citral.". FEMS Microbiology Letters 354 2 (2014): 92-101. https://doi.org/10.1111/1574-6968.12440.
    Publicado • 10.1111/1574-6968.12440
Capítulo de livro
  1. Apolónio, Joana ; Fernandes, Mónica T; Leão, Ricardo Romão Nazário; Paredes, Joana. "Mecanismos moleculares do cancro". In Fisiopatologia - bases da medicina moderna. Portugal, 2024.
    Em revisão
Poster em conferência
  1. Paiva-Correia, António; Apolónio, Joana ; Pedro Castelo-Branco; Henrik Hellquist. "Salivary gland tumours are epigenetically regulated by THOR methylation.". Trabalho apresentado em 36th European Congress of Pathology, 7 - 11 September 2024 | Florence, Italy, 2024.
  2. Apolónio, Joana ; Cardoso, Candida; Pedro Castelo-Branco. "THOR: Tert Hypermethylated Oncologic Region- a novel breast cancer biomarker for liquid biopsy.". Trabalho apresentado em 6th ASPIC International Congress, April 29th and 30th, 2024, University of Algarve, Faro, Portugal, 2024.
  3. Mónica Ramos; Daniela Santos; A.T. Rajado; Apolónio, Joana Dias; Nádia Margarida Silva; Pedro Castelo-Branco. "Associations between a DNA methylation-based telomere length estimator, the redox state, diet, and aging in the Algarve population.". Trabalho apresentado em X Workshop de Bioquímica Clínica (IX-CBW), University of Algarve, 2024, 2024.
  4. Fernandes, Mónica T.; Apolónio, Joana ; Esteves, Filipa; De Sousa-Coelho, Ana Luísa; Sofia M. Calado; Marreiros, Ana; Pedro Castelo-Branco. "Unveiling a novel epigenetic biomarker for personalized medicine in gliomas". Trabalho apresentado em Congresso Nacional dos Farmacêuticos, CNF24: Mais Inovação, Melhor Saúde, 2024.
  5. Fernandes, Mónica Teotónio; Apolónio, Joana Dias; De Sousa-Coelho, Ana Luísa; Pedro Castelo-Branco. "CITED4 methylation is a novel prognosis biomarker in gliomas". Trabalho apresentado em EACR-AstraZenecaCancer Epigenetics Virtual Event, Worldwide, 2023.
  6. Apolónio, Joana ; Gabriela Valadas; Fernandes, Mónica Teotónio. "THOR A targetable epigenetic biomarker in BC, finding new paths for its use". Trabalho apresentado em XX Jornadas de Senologia, October 13 and 14, 2023, Palácio de Congresso do Algarve, Albufeira, Portugal., 2023.
  7. Apolónio, Joana Dias; Nádia Margarida Silva; ALFA Score consortium. "ALFA Score - Algarve Fit Ageing Score Project, a multidisciplinary approach for ageing assessment". Trabalho apresentado em 19º EuGMS Congress, 20 – 22 September 2023, Helsinki, Finland., 2023.
  8. Rajado, Ana Teresa; Pestana, Daniel; Silva, Nádia; Apolónio, Joana ; Esteves, Filipa; Brito, David V.C.; Trindade, Marlene; et al. Autor correspondente: Pedro Castelo-Branco. "Algarve Fit Ageing Score Project, A Multidisciplinary Approach To Assess Healthy Ageing Status". Trabalho apresentado em EMBO Workshop Systems Biology: Linking chromatin and Epigenetics to Disease and Development, 2023.
  9. Apolónio, Joana Dias; Fernandes, Mónica Teotónio; Pedro Castelo-Branco; Bragança, José. "CITED4 methylation status is a potential prognostic biomarker for glioma in elderly patients". Trabalho apresentado em International Conference Ageing Without Borders; December 6 and 7, 2022, Faro, Portugal., 2022.
  10. Apolónio, Joana Dias; Andrade, Raquel G. D.; Nádia Margarida Silva; Pedro Castelo-Branco; Ana Teresa Rajado; ALFA Score consortium. "ALFA Score - Algarve Fit Ageing Score Project, a multidisciplinary approach for ageing assessment". Trabalho apresentado em ABC Days, October 12 – 14, 2022, Sagres, Portugal., 2022.
  11. Fernandes, MT; Apolónio, Joana Dias; Castelo-Branco, Pedro; Bragança, J.. "CITED4 role in gliomas - revisiting previous studies and providing new clues". Trabalho apresentado em ABC Days, October 12 – 14, 2022, Sagres, Portugal., 2022.
  12. Apolónio, Joana Dias; ALFA Score consortium. "ALFA Score - Algarve Fit Ageing Score Project, a multidisciplinary approach for ageing assessment". Trabalho apresentado em International Conference Ageing Without Borders; December 6 and 7, 2022, Faro, Portugal., 2022.
  13. Rajado, Ana Teresa; Raquel P. Andrade; Apolónio, Joana ; Inês Maria Pombinho de Araújo; Brito, David V.C.; Sofia M. Calado; Esteves, Filipa; et al. "ALFA Score - Algarve Fit Ageing Score". Trabalho apresentado em ABC-Days, 2022.
  14. Apolónio, Joana Dias; Fernandes, Mónica Teotónio. "THOR is a targetable epigenetic biomarker with clinical implications in breast cancer". Trabalho apresentado em 5th Aspic International Congress, June 30th and July 1st, at the IPO-Porto Auditorium, 2022, Porto, Portugal., 2022.
  15. Fernandes, Mónica T; Apolónio, Joana Dias; Castelo-Branco, P.; Bragança, José. "CITED4 hypomethylation in the 3’UTR is associated with an adverse prognosis in glioblastoma". Trabalho apresentado em 5th Aspic International Congress, June 30th and July 1st, at the IPO-Porto Auditorium, 2022, Porto, Portugal., 2022.
  16. Apolónio, Joana ; Pedro Castelo-Branco; Vânia Palma Roberto; Gabriela Valadas; João Silva Dias; Uri Tabori. "THOR: A DNA methylation-based marker for breast cancer". Trabalho apresentado em XVIII Jornadas de Senologia, Portimão, Portugal., 2019.
  17. Pereira RM; Pimenta, J.; Castelo-Branco P; Apolónio, Joana Dias; Pires VMR; Nolasco S; Marques CC; et al. "Epigenetic behavior of prion-type genes in bovine granulosa cells (abstract p.69)". Trabalho apresentado em XI Congreso Ibérico sobre Recursos Genéticos Animales (SERGA-SPREGA), 2018.
  18. Jorge Pimenta; Apolónio, Joana ; Pedro Castelo-Branco; Pires V.M; Nolasco S. "Comportamento epigenético de genes do tipo priónico em células da granulosa de bovino.". Trabalho apresentado em XI Congreso Ibérico sobre Recursos Genéticos Animales. Murcia, Spain., 2018.
  19. Apolónio, Joana ; Pedro Castelo-Branco; Uri Tabori. "A DNA methylation-based marker for breast cancer management". Trabalho apresentado em Keystone Symposia Conference, Cancer Epigenetics: New Mechanisms, New Therapies. Breckenridge, Colorado, USA., 2018.
  20. Apolónio, Joana ; Bernardo Pereira de Almeida; Alexandra Binnie; Pedro Castelo-Branco. "Roadmap of DNA methylation in breast cancer identifies 15 novel potential biomarkers". Trabalho apresentado em 2nd CBMR/ProRegem Annual Meeting, Faro, Portugal., 2017.
  21. Vânia Palma Roberto; Apolónio, Joana ; Pedro Castelo-Branco. "Uncovering new epigenetic biomarkers in colorectal cancer.". Trabalho apresentado em 2nd CBMR/ProRegem Annual Meeting, Faro, Portugal., 2017.
  22. Leão, Ricardo; Lee, Donghyun; Apolónio, Joana ; Figueiredo, Arnaldo; Pedro Castelo-Branco; Uri Tabori. "Integrated molecular signatures of TERT promoter deregulation predict disease progression in non-muscle invasive bladder cancer". Trabalho apresentado em Telomeres & Telomerase Meeting, Cold Spring Harbor, NY, USA., 2017.
  23. Apolónio, Joana ; Vânia Palma Roberto; Uri Tabori; Pedro Castelo-Branco. "Uncovering the potential of a DNA methylation-based biomarker for breast cancer.". Trabalho apresentado em Genetics and Genome Biology Annual Retreat. Sickkids Hospital, University of Toronto, Canada., 2017.
  24. Sara Ramalhete; Apolónio, Joana ; Pedro Castelo-Branco. "Dna Methylation patterns in oncogenes and tumor suppressors in breast cancer.". Trabalho apresentado em 1st CBMR/ProRegem Annual Meeting, Faro, Portugal., 2016.
  25. Apolónio, Joana ; Célia Domingos; Pedro Castelo-Branco. "Uncovering the potential of THOR as a biomarker for breast cancer". Trabalho apresentado em 2nd ASPIC International Congress, IPO, Porto, Portugal., 2016.
  26. Célia Domingos; Luís Relvas; Apolónio, Joana ; Pedro Castelo-Branco. "THOR methylation as a new tool for the clinical management of colorectal cancer". Trabalho apresentado em 2nd ASPIC International Congress, IPO, Porto, Portugal., 2016.
Tese / Dissertação
  1. Apolónio, Joana. "TERT Hypermethylated Oncologic Region (THOR) as a Biomarker for Breast Cancer". Doutoramento, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2019.
  2. Apolónio, Joana. "Acquisition of tolerance to essential oil components by pathogenic bacteria.". Mestrado, Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, 2013.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/10/05 Biomarcador THOR: novo alvo de diagnóstico precoce no cancro da mama? Highlights no Cancro da Mama para Clínicos 2024
Lusíadas Knowledge Center (Faro, Portugal)
2023/05/24 Wellness & Healthcare Tourism IPBN Tourism Conference, May 24, 2023, Quinta do Lago, Clubhouse, Portugal
IPBN
2023/02/17 Investigation of biomarkers and their application in clinical practice. 2º Congresso do Cancro da Mama do Algarve, Hotel Vila Galé - Lagos, Portugal.
2022/07/14 A revisão por pares como meio de desenvolvimento da escrita científica em contexto de aula Congresso Nacional de Práticas Pedagógicas no Ensino Superior (CNaPPES), Coimbra
(Coimbra, Portugal)
2022/05/28 DNA methylation and its potential as a biomarker in breast cancer VII Congresso Luso-Brasileiro de Patologia Experimental, May 28, 2022, Coimbra, Portugal.
2021/10/08 Epigenetic alterations associated with aging. IV Jornadas do Algarve Biomedical Center-ABC
Algarve Biomedical Center (Moura, Portugal)
2019/03/29 Targeted DNA Demethylation of TERT hypermethylated oncologic region (THOR) in Breast Cancer. 3rd Annual Meeting of Algarve Biomedical Center
Algarve Biomedical Center ( Albufeira, Portugal)
2018/11/16 Gene silencing (siRNA) of Bos taurus prion-like genes, and its relation to progesterone (P4) and 17b-estradiol (E2) concentrations. Exploring the boundaries of animal, veterinary and biomedical sciences. CIISA congress 2018
CIISA- Centre for Interdisciplinary Research in Animal Health (Lisbon, Portugal)
2018/05/10 TERT methylation: a potential diagnostic and prognostic tool for the management of colorectal cancer. 3rd ASPIC International Congress
Portuguese Association for Cancer Research (Lisbon, Portugal)
2018/03/16 TERT methylation in colorectal cancer: from molecular mechanisms to clinic significance 2nd Annual Meeting of Algarve Biomedical Center
Algarve Biomedical Center (Olhão, Portugal)
2015/11/13 THOR as a biomarker for breast cancer. VII National Meeting of Health Sciences and Technology
Lisbon School of Health Technology (Lisbon, Portugal)
2011/10/21 Obesity influence on lipid profile of patients with diabetes mellitus type II. VI National Meeting of Health Sciences and Technology
Lisbon School of Health Technology (Lisbon, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/11/01 - Atual THORbio: a new liquid biopsy biomarker for breast cancer detection and monitoring.
Orientador
 PhD in Biomedical Sciences (Doutoramento)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2023/03/13 - 2023/04/20 Supervisor of medical student, Susana Matias, on An exploratory study of PRAC2, TDRD10, and TMEM132C genes as new potential epigenetic biomarkers for diagnosis and prognosis in breast cancer, Traineeship. Faculty of Medicine and Biomedical Sciences, UAlg.
Orientador
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2022/03/15 - 2022/04/20 Supervisor of medical student, Sofia Gomes, on DNA methylation as a new biomarker in pancreatic ductal adenocarcinoma via TGF-ß and Hedgehog signaling pathways, Traineeship. Faculty of Medicine and Biomedical Sciences, University of Algarve, Faro, Portugal.
Orientador
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2021/05/01 - 2022/03/24 Identification of new epigenetic biomarkers in urothelial bladder cancer.
Coorientador
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/01/04 - 2016/06/30 DNA methylation patterns in Oncogenes and Tumor Suppressors”
Coorientador
 Biochemical Sciences (Licenciatura/Bacharelato)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2024/10/27 - 2024/10/27 3rd Edition of the Solidarity walk and run “Mama em Movimento”, organized by ABC in partnership with the Algarviana Team - Cultural and Sports Association, and with the support of the Algarve Oncological Association (AOA) and Portuguese Cancer League (LPCC-NRS), October 27, 2024, Faro, Portugal. (2024/10/27 - 2024/10/27)
Outro (Presidente da Comissão Organizadora)
 Algarve Biomedical Center, Portugal
2023/10/29 - 2023/10/29 2nd edition of the Solidarity walk and run Mama em Movimento, organized by ABC in partnership with the Algarviana Team - Cultural and Sports Association, and with the support of the Algarve Oncological Association (AOA) and Portuguese Cancer League (LPCC-NRS), October 29, 2023, Faro, Portugal. (2023/10/29 - 2023/10/29)
Outro (Presidente da Comissão Organizadora)
 Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
2022/12/06 - 2022/12/07 Member of the Organizing Committee of the International Conference Aging Without Borders, December 6-7, 2022, Faro, Portugal. (2022/12/06 - 2022/12/07)
Congresso (Membro da Comissão Organizadora)
 Algarve Biomedical Center Research Institute, Portugal
2022/10/23 - 2022/10/23 1st edition of the Solidarity walk and run ¿Mama em Movimento¿, organized by ABC in partnership with the Algarviana Team - Cultural and Sports Association, and with the support of the Algarve Oncological Association (AOA) October 23, 2022, Faro, Portugal. (2022/10/23 - 2022/10/23)
2021/03/10 - 2021/03/10 Organization of the International Conference "Clinical Academic Centers: The Impact on Clinical Research", March 10, 2021, Cineteatro Louletano, Loulé. Hybrid event (in person and live online). (2021/03/10 - 2021/03/10) Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
2018/10/22 - 2018/10/31 Organization of a fundraising to support breast cancer care in collaboration with Algarve Oncology Association. Raising awareness and sharing information about Breast Cancer and the role of Algarve Oncology Association. Promote the collection of donations to support the fight against breast cancer. (2018/10/22 - 2018/10/31)
Outro (Coorganizador)
 Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Associação Oncológica do Algarve, Portugal
2017/09/08 - 2017/09/08 Organization of the 2nd CBMR/ProRegem Annual Meeting (2017/09/08 - 2017/09/08)
Encontro (Membro da Comissão Organizadora)
 Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2016/07/01 - 2016/07/01 Organization of the 1st CBMR/ProRegem annual meeting. (2016/07/01 - 2016/07/01)
Encontro (Membro da Comissão Organizadora)
 Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2025/02/04 - 2025/02/04 X JORNADAS DE INVESTIGAÇÃO EM ONCOLOGIA, organized by Portuguese League Against Cancer - South Regional Nucleus (LPCC-NRS).
Encontro
 X JORNADAS DE INVESTIGAÇÃO EM ONCOLOGIA
Liga Portuguesa Contra o Cancro Núcleo Regional do Sul, Portugal
2024/11/20 - 2024/11/20 Participation in the Science and Technology Week - ABC-RI Day at CCV Algarve, Activity for the 3rd Cycle and Secondary School, entitled “Are we the same age as our cells? Aging begins when we are born and from the age of 25 physical decline begins. What factors allow us to live longer and better?”, organized by the Life Sciences Center of Algarve and University of Algarve, November 20, 2024, Faro, Portugal.
Seminário
 Science and Technology Week - ABC-RI Day at CCV Algarve
Algarve Biomedical Center Research Institute, Portugal

Life Sciences Center of Algarve , Portugal

Universidade do Algarve, Portugal
2024/10/01 - 2024/10/01 Participation in the National Cancer Hub - PT Session, organized by AICIB and DGS, at Secção Regional do Norte da Ordem dos Médicos, Sala Braga, October 1, 2024, Porto, Portugal.
Mesa-redonda
 National Cancer Hub - PT Session
AICIB - Agência de Investigação Clínica e Inovação Biomédica, Portugal
2024/04/12 - 2024/04/12 IX JORNADAS DE INVESTIGAÇÃO EM ONCOLOGIA, organized by Portuguese League Against Cancer - South Regional Nucleus (LPCC-NRS).
Encontro
 IX JORNADAS DE INVESTIGAÇÃO EM ONCOLOGIA
Liga Portuguesa Contra o Cancro Núcleo Regional do Sul, Portugal
2020/03/09 - 2020/03/12 Clarification sessions about COVID-19 disease to the community and companies
Seminário
Algarve Biomedical Center, Portugal
2016/11/21 - 2016/11/25 European Week of Science, organized by the Life Sciences Center of Algarve and University of Algarve
Seminário
 European Week of Science.
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Life Sciences Center of Algarve , Portugal
2014/12/17 - 2014/12/17 Monitor of students from the student award winners “Uma Forma de Cancro”, Life Sciences Center of Algarve and DCBM, University of Algarve, Faro, Portugal.
Oficina (workshop)
 Student award winners “Uma Forma de Cancro”
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Life Sciences Center of Algarve , Portugal
2013/05/15 - 2013/05/15 Participation in the project "Being a Doctor and /or Scientist for a day".
Exposição
 Project "Being a Doctor and /or Scientist for a day".
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/10/08 Bachelor's Degree in Biomedical Sciences, at Faculty of Medicine and Biomedical Sciences, of Graduate João Coelho – dissertation on “MicroRNAs circulantes preditores do sucesso da cirurgia bariátrica”.
Arguente principal
 João Coelho (Outro)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2022/07/07 Effects of Carica papaya extracts on expression patterns of fetal hemoglobin regulatory genes.
Arguente principal
 Maria Inês Mendes (Mestrado)
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019/03/04 - 2019/05/31 Seminars for the Pharmacy degree: “Technologies for genome edition”, May 14. (3h) “Molecular Biology of Cancer”, April 23. (3h) Practical class: “Restriction enzymes, cloning and plasmid DNA extraction”, April 3. (4h) Pharmacy (Licenciatura) Universidade do Algarve Escola Superior de Saúde, Portugal
2016/10/04 - 2016/10/29 Seminars for the advanced course in Applied Epigenetics to the Clinical Laboratory Diagnosis: “Discussion of the role of Epigenetics in clinical laboratory diagnosis”, October 27. (3h) “Databases: Roadmap Epigenomics Project and TCGA”, October 22. (4h) “Epigenetic alterations associated to breast cancer”, October 20. (3h) Advanced course in Applied Epigenetics to the Clinical Laboratory Diagnosis (Outros) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2015/01/05 - 2015/03/08 Seminar for the classes of Oncolabs II of the Master in Oncobiology: “Extraction, Restriction and electrophoresis of plasmidic DNA”, January 12 (4h). Master in Oncobiology (Mestrado) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2014/02/17 - 2014/05/30 Seminar for the Technology and Food Safety Degree, “Innate Immune System, April 30 (2h). Technology and Food Safety (Licenciatura) Universidade do Algarve, Portugal

Membro de associação

Nome da associação Tipo de participação
2015 - Atual ASPIC - Portuguese Association for Cancer Research.
2015 - Atual EACR - European Association of Cancer Research.

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020/04/30 - 2020/05/19 Member of the evaluation committee of the proposals submitted to the 2nd edition of FCT-Research4Covid19.
Membro
 Fundação para a Ciência e a Tecnologia, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2018/11/01 - 2018/11/20 Reviewer of the article “MiR-202 inhibits cell proliferation, invasion and migration in breast cancer by targeting ROCK1 gene” Journal of Cellular Biochemistry, Manuscript ID: JCB-18-2656. November, 2018. Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Tutoria

Tópico Nome do aluno
2017/01/02 - 2017/02/03 “DNA methylation patterns of MGP in cancer”. Nuno Carrasco
2017/01/02 - 2017/02/03 “Methylation Patterns in Tumor Suppressor Genes and Oncogenes involved in Breast Cancer”. Maria Mouzinho
2016/01/04 - 2016/02/05 "Epigenetic regulation of TERT Hypermethylated Oncologic Region (THOR) and its implications in the diagnosis and prognosis of Colorectal Cancer" Luis Relvas
2015/06/20 - 2015/07/28 “THOR methylation in pancreatic and thyroid carcinoma”. Inês Faleiro
Distinções

Prémio

2025 Oncology Research Fellowship LPCC-NRS 2025
Liga Portuguesa Contra o Cancro Núcleo Regional do Sul, Portugal
2019 Best oral communication entitled “Targeted DNA Demethylation of TERT hypermethylated oncologic region (THOR) in Breast Cancer”
Algarve Biomedical Center, Portugal
2017 EACR Travel Fellowship
European Association For Cancer Research, Reino Unido
2016 Award of excellence from the Directorate General for Higher Education (DGES)
Direção-Geral do Ensino Superior (DGES), Portugal
2015 Merit award of Master Degree in Biomedical Sciences from New University of Lisbon
Universidade Nova de Lisboa, Portugal
2012 Merit Award of Degree in Biomedical Laboratory Sciences
Caixa Geral de Depositos, Portugal

Outra distinção

2011 Erasmus Scholarship
Ministério da Educação, Portugal