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Domingos de Carvalho Ferreira. Graduated in pharmaceutical sciences in 1984 and completed his PhD at the Faculdade de Farmácia, University of Porto in 1992. Currently a Full Professor at the Faculdade de Farmácia, University of Porto, member of the Quality Working Party at the European Medicines Agency, Vice-President of the evaluating commitee at Infarmed, and Full Professor at REQUIMTE, Applied biomolecular sciences unit. He has published 118 journal articles in Q1 journals. Has authored 4 books. He has participated/is currently participing in 6 porjects and was Principal Investigator in 2 projects. Research is focused on health sciences. At his CV, the most frequent topics of scientifc output are Health sciences, pharmacology and pharmacological sciences.
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Identificação

Identificação pessoal

Nome completo
Domingos de Carvalho Ferreira

Nomes de citação

  • Ferreira, Domingos

Identificadores de autor

Ciência ID
1C18-A963-BC5E
ORCID iD
0000-0001-6200-7169

Endereços de correio eletrónico

  • domingos@ff.up.pt (Profissional)

Telefones

Telemóvel
  • 919364623 (Pessoal)

Moradas

  • Faculdade de Farmácia da Universidade do Porto. Rua de Jorge Viterbo Ferreira n.º 228, 4050-313, Porto, Porto, Portugal (Profissional)
  • Rua Académica de S. Mamede, 90, 4465-015, S. Mamede de Infesta, Matosinhos, Portugal (Pessoal)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Italiano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Inglês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
1992
Concluído
 PhD Program (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Benzodiazepinas: Contribuição para o estudo de preparações farmacêuticas " (TESE/DISSERTAÇÃO)
 “Distinção e Louvor” por unanimidade
1984
Concluído
 Farmácia (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
 14 Valores
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2016 - Atual Professor Catedrático (Docente Universitário) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2012/06/25 - Atual Professor Catedrático (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
2003/09/16 - 2012/06/25 Professor Associado (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
2003 - 2012 Professor Associado (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
1992 - 2003 Professor Auxiliar (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
1987 - 1992 Assistente (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
1984 - 1987 Assistente Estagiário (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
1983 - 1984 Monitor (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2000/01/01 - Atual Quality Working Party member European Medicines Agency, Reino Unido
1993/01/01 - Atual Vice-present of the commitee of medicines' evaluation Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
1996/01/01 - 2012/05/01 Member of the European Pharmacopoeia Comission Council of Europe, França
1995/01/01 - 2012/05/01 Secretary of the delegacy of the Farmacopeia Portiguesa Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
1993 - 2012 Member of the delegacy of the Farmacopeia Portuguesa Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - Atual PANCREASMIMETIC - Establishment of a multifunctional stimuli-responsive pancreas mimetic
PTDC/MED-OUT/30466/2017, POCI-01-0145-FEDER-030466
Orientador
Em curso

Projeto

Designação Financiadores
2017 - Atual Castanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications: A sustainable approach
PTDC/ASP-AGR/29277/2017
Investigador
Universidade do Porto Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2014 - Atual Navigating through marine-derived fungi "
PTDC/MAR-BIO/4694/2014.
Investigador
Universidade do Porto Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
2014 - Atual Navigating through marine-derived fungi "
PTDC/MAR-BIO/4694/2014.
 Fundação para a Ciência e a Tecnologia
2011 - Atual Desenvolvimento de filmes vaginais contendo nanopartículas carregadas com antiretrovíricos em combinação para prevenção da transmissão
VIH - VIH/SAU/0021/2011
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - Atual EncapsDevice: Development of polymeric nanostructures for nasal and pulmonary delivery of peptides and proteins
info:eu-repo/grantAgreement/FCT/3599-PPCDT/100291/PT
Investigador
Universidade do Porto Faculdade de Farmácia, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
2009 - Atual Development of a dynamic human cell model of the blood-brain barrier and a liposome membrane model to test the passage into the brain of drugs incorporated into lipid nanoparticles. Correlations in vivo / in vitro
PTDC / SAU-FAR / 112277/2009.
Investigador responsável
Universidade do Porto Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2008 - Atual NanoFreeze - lyophilization process as a strategy to reduce the instability of therapeutic proteins encapsulated in nanoparticles
PTDC / SAU-FCF / 104492/2008
Investigador
Universidade do Porto Faculdade de Farmácia, Portugal
Concluído
2008 - Atual NanoFreeze - lyophilization process as a strategy to reduce the instability of therapeutic proteins encapsulated in nanoparticles
PTDC / SAU-FCF / 104492/2008
 N/A
2007 - Atual "Study of controlled release of medicines and development of automated analysis techniques incorporating electrochemical sensors for monitoring its"
PRAXIS XXI
Investigador
Universidade do Porto Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2006 - Atual "In vivo / in vitro correlation of intestinal absorption of proteins using animals models and shard-2 based co-culture cell lines"
PTDC / SAU-FCT / 70651/2006
Investigador responsável
Universidade do Porto Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/06/01 - 2019/06/01 Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents
PTDC/MAR-BIO/4694/2014
Provided by PTCRIS: 143327
POCI-01-0145-FEDER-016790
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Fundação Ensino e Cultura Fernando Pessoa, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Marques, Claudia; Azevedo, Ana Rita; Carvalho, Isabel; Bárbara B. Mendes; Ferreira, M.; Ferreira, G.; Moreira, A. R.; et al. "Solid lipid nanoparticles as carriers for camptothecin delivery to brain tumor using an in vitro blood brain barrier model.". Trabalho apresentado em 51st Congress of the European Societies of Toxicology (EUROTOX), Porto, 2015.
    Aceite para publicação
  2. Teixeira, J.; Gehm, C.; Júlio, A.; Castro, C.; Fonseca, J.; Martins, S.; Ferreira, D.; Sarmento, B.. "Chitosan as mucoadhesive agent to enhance absorption of therapeutic proteins encapsulated into solid lipid nanoparticles". 2009.
Artigo em jornal
  1. João Paulo Peixoto; Vasco Miguel de Almeida Marques; Paula Santos; Reinaldo Ferreira; STEFANI, SILVIO ROBERTO; Ferreira, Domingos. "Online advertising performance: facebook and google", International Journal of Development Research, 2021, https://doi.org/10.37118/ijdr.23319.12.2021.
Artigo em revista
  1. Vieira, A.C.C.; Chaves, L.L.; Pinheiro, M.; Lima, S.C.; Neto, P.J.R.; Ferreira, D.; Sarmento, B.; Reis, S.. "Lipid nanoparticles coated with chitosan using a one-step association method to target rifampicin to alveolar macrophages". Carbohydrate Polymers 252 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85091926219&partnerID=MN8TOARS.
    10.1016/j.carbpol.2020.116978
  2. Campos, J.C.; Cunha, D.; Ferreira, D.C.; Reis, S.; Costa, P.J.. "Oromucosal precursors of in loco hydrogels for wound-dressing and drug delivery in oral mucositis: Retain, resist, and release". Materials Science and Engineering C 118 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090214906&partnerID=MN8TOARS.
    10.1016/j.msec.2020.111413
  3. Sousa, F.; Ferreira, D.; Reis, S.; Costa, P.. "Current insights on antifungal therapy: Novel nanotechnology approaches for drug delivery systems and new drugs from natural sources". Pharmaceuticals 13 9 (2020): 1-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090823870&partnerID=MN8TOARS.
    10.3390/ph13090248
  4. Alves, A.; Correia-da-Silva, M.; Nunes, C.; Campos, J.; Sousa, E.; Silva, P.M.A.; Bousbaa, H.; et al. "Discovery of a new xanthone against glioma: Synthesis and Development of (Pro)liposome Formulations". Molecules 24 3 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060533704&partnerID=MN8TOARS.
    10.3390/molecules24030409
  5. Chaves, L.L.; Silveri, A.; Vieira, A.C.C.; Ferreira, D.; Cristiano, M.C.; Paolino, D.; Di Marzio, L.; et al. "pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization". International Journal of Biological Macromolecules 133 (2019): 1268-1279. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065421875&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2019.04.178
  6. Campos, J.C.; Ferreira, D.C.; Lima, S.; Reis, S.; Costa, P.J.. "Swellable polymeric particles for the local delivery of budesonide in oral mucositis". International Journal of Pharmaceutics 566 (2019): 126-140. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066149158&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2019.05.057
  7. Alexandre C. C. Vieira; Luíse L. Chaves; Marina Pinheiro; Sofia A. Costa Lima; Domingos Ferreira; Bruno Sarmento; Salette Reis. "Mannosylated solid lipid nanoparticles for the selective delivery of rifampicin to macrophages". Artificial Cells, Nanomedicine, and Biotechnology 46 sup1 (2018): 653-663. https://doi.org/10.1080/21691401.2018.1434186.
    10.1080/21691401.2018.1434186
  8. Chaves, L.L.; Costa Lima, S.A.; Vieira, A.C.C.; Barreiros, L.; Segundo, M.A.; Ferreira, D.; Sarmento, B.; Reis, S.. "Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability". European Journal of Pharmaceutical Sciences 112 (2018): 28-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033398806&partnerID=MN8TOARS.
    10.1016/j.ejps.2017.11.004
  9. Vieira, A.C.C.; Chaves, L.L.; Pinheiro, S.; Pinto, S.; Pinheiro, M.; Lima, S.C.; Ferreira, D.; Sarmento, B.; Reis, S.. "Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosis". International Journal of Pharmaceutics 536 1 (2018): 478-485. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037993500&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2017.11.071
  10. Braz, L.; Grenha, A.; Corvo, M.C.; Lourenço, J.P.; Ferreira, D.; Sarmento, B.; Rosa da Costa, A.M.. "Synthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticles". Carbohydrate Polymers 181 (2018): 974-985. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035047109&partnerID=MN8TOARS.
    10.1016/j.carbpol.2017.11.052
  11. Chaves, L.L.; Costa Lima, S.A.; Vieira, A.C.C.; Barreiros, L.; Segundo, M.A.; Ferreira, D.; Sarmento, B.; Reis, S.. "Nanosystems as modulators of intestinal dapsone and clofazimine delivery". Biomedicine and Pharmacotherapy 103 (2018): 1392-1396. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052816711&partnerID=MN8TOARS.
    10.1016/j.biopha.2018.04.195
  12. Chaves, L.L.; Lima, S.; Vieira, A.C.C.; Ferreira, D.; Sarmento, B.; Reis, S.. "Overcoming clofazimine intrinsic toxicity: statistical modelling and characterization of solid lipid nanoparticles". Journal of the Royal Society Interface 15 139 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85048526062&partnerID=MN8TOARS.
    10.1098/rsif.2017.0932
  13. Campos, J.C.; Cunha, J.D.; Ferreira, D.C.; Reis, S.; Costa, P.J.. "Challenges in the local delivery of peptides and proteins for oral mucositis management". European Journal of Pharmaceutics and Biopharmaceutics 128 (2018): 131-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046344996&partnerID=MN8TOARS.
    10.1016/j.ejpb.2018.04.025
  14. Nascimento, A.V.; Singh, A.; Bousbaa, H.; Ferreira, D.; Sarmento, B.; Amiji, M.M.. "Overcoming cisplatin resistance in non-small cell lung cancer with Mad2 silencing siRNA delivered systemically using EGFR-targeted chitosan nanoparticles". Acta Biomaterialia 47 (2017): 71-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991255345&partnerID=MN8TOARS.
    10.1016/j.actbio.2016.09.045
  15. Braz, L.; Grenha, A.; Ferreira, D.; Rosa da Costa, A.M.; Gamazo, C.; Sarmento, B.. "Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization". International Journal of Biological Macromolecules 96 (2017): 786-797. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008620894&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2016.12.076
  16. Chaves, L.L.; Costa Lima, S.A.; Vieira, A.C.; Barreiros, L.; Segundo, M.A.; Ferreira, D.; Sarmento, B.; Reis, S.. "PH-sensitive nanoparticles for improved oral delivery of dapsone: Risk assessment, design, optimization and characterization". Nanomedicine 12 16 (2017): 1975-1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026748544&partnerID=MN8TOARS.
    10.2217/nnm-2017-0105
  17. Vieira, A.C.C.; Chaves, L.L.; Pinheiro, M.; Ferreira, D.; Sarmento, B.; Reis, S.. "Design and statistical modeling of mannose-decorated dapsone-containing nanoparticles as a strategy of targeting intestinal M-cells". International Journal of Nanomedicine 11 (2016): 2601-2617. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973495882&partnerID=MN8TOARS.
    10.2147/IJN.S104908
  18. Nascimento, A.V.; Gattacceca, F.; Singh, A.; Bousbaa, H.; Ferreira, D.; Sarmento, B.; Amiji, M.M.. "Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models". Nanomedicine 11 7 (2016): 767-781. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962124740&partnerID=MN8TOARS.
    10.2217/nnm.16.14
  19. da Silva, S.B.; Ferreira, D.; Pintado, M.; Sarmento, B.. "Chitosan-based nanoparticles for rosmarinic acid ocular delivery-In vitro tests". International Journal of Biological Macromolecules 84 (2016): 112-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950272691&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2015.11.070
  20. Andrade, F.; Fonte, P.; Costa, A.; Reis, C.C.; Nunes, R.; Almeida, A.; Ferreira, D.; Oliva, M.; Sarmento, B.. "Pharmacological and toxicological assessment of innovative self-Assembled polymeric micelles as powders for insulin pulmonary delivery". Nanomedicine 11 17 (2016): 2305-2317. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984604987&partnerID=MN8TOARS.
    10.2217/nnm-2016-0045
  21. Cunha-Reis, C.; Machado, A.; Barreiros, L.; Araújo, F.; Nunes, R.; Seabra, V.; Ferreira, D.; et al. "Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs". Journal of Controlled Release 243 (2016): 43-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990849820&partnerID=MN8TOARS.
    10.1016/j.jconrel.2016.09.020
  22. Machado, A.; Cunha-Reis, C.; Araújo, F.; Nunes, R.; Seabra, V.; Ferreira, D.; das Neves, J.; Sarmento, B.. "Development and in vivo safety assessment of tenofovir-loaded nanoparticles-in-film as a novel vaginal microbicide delivery system". Acta Biomaterialia 44 (2016): 332-340. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992121833&partnerID=MN8TOARS.
    10.1016/j.actbio.2016.08.018
  23. Nascimento, A.V.; Bousbaa, H.; Ferreira, D.; Sarmento, B.. "Non-small cell lung carcinoma: An overview on targeted therapy". Current Drug Targets 16 13 (2015): 1448-1463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946402070&partnerID=MN8TOARS.
  24. Nascimento, A.V.; Singh, A.; Bousbaa, H.; Ferreira, D.; Sarmento, B.; Amiji, M.M.. "Combinatorial-Designed Epidermal Growth Factor Receptor-Targeted Chitosan Nanoparticles for Encapsulation and Delivery of Lipid-Modified Platinum Derivatives in Wild-Type and Resistant Non-Small-Cell Lung Cancer Cells". Molecular Pharmaceutics 12 12 (2015): 4466-4477. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948985757&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.5b00642
  25. Carvalho, I.M.; Coelho, P.B.; Costa, P.C.; Marques, C.S.; Oliveira, R.S.; Ferreira, D.C.. "Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders". NeuroMolecular Medicine 17 4 (2015): 404-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947127602&partnerID=MN8TOARS.
    10.1007/s12017-015-8369-3
  26. Andrade, F.; Neves, J.D.; Gener, P.; Schwartz, S.; Ferreira, D.; Oliva, M.; Sarmento, B.. "Biological assessment of self-assembled polymeric micelles for pulmonary administration of insulin". Nanomedicine: Nanotechnology, Biology, and Medicine 11 7 (2015): 1621-1631. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942105468&partnerID=MN8TOARS.
    10.1016/j.nano.2015.05.006
  27. Da Silva, S.B.; Amorim, M.; Fonte, P.; Madureira, R.; Ferreira, D.; Pintado, M.; Sarmento, B.. "Natural extracts into chitosan nanocarriers for rosmarinic acid drug delivery". Pharmaceutical Biology 53 5 (2015): 642-652. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924364390&partnerID=MN8TOARS.
    10.3109/13880209.2014.935949
  28. Andrade, F.; Fonte, P.; Oliva, M.; Videira, M.; Ferreira, D.; Sarmento, B.. "Solid state formulations composed by amphiphilic polymers for delivery of proteins: Characterization and stability". International Journal of Pharmaceutics 486 1-2 (2015): 195-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926357674&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2015.03.050
  29. Chaves, L.L.; Vieira, A.C.C.; Ferreira, D.; Sarmento, B.; Reis, S.. "Rational and precise development of amorphous polymeric systems with dapsone by response surface methodology". International Journal of Biological Macromolecules 81 (2015): 662-671. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941216501&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2015.08.009
  30. Carvalho, I.M.; Marques, C.S.; Oliveira, R.S.; Coelho, P.B.; Costa, P.C.; Ferreira, D.C.. "Sustained drug release by contact lenses for glaucoma treatment - A review". Journal of Controlled Release 202 (2015): 76-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922575853&partnerID=MN8TOARS.
    10.1016/j.jconrel.2015.01.023
  31. Mendes, B.; Marques, C.; Carvalho, I.; Costa, P.; Martins, S.; Ferreira, D.; Sarmento, B.. "Influence of glioma cells on a new co-culture in vitro blood-brain barrier model for characterization and validation of permeability". International Journal of Pharmaceutics 490 1-2 (2015): 94-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929990184&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2015.05.027
  32. Nascimento AV; Singh A; Bousbaa H; Ferreira D; Sarmento B; Amiji MM. "Mad2 Checkpoint Gene Silencing Using Epidermal Growth Factor Receptor-Targeted Chitosan Nanoparticles in Non-Small Cell Lung Cancer Model.". (2014): http://europepmc.org/abstract/med/25256346.
  33. Nascimento AV; Bousbaa H; Ferreira D; Sarmento B. "Non-small Cell Lung Carcinoma: An Overview on Targeted Therapy.". (2014): http://europepmc.org/abstract/med/24875380.
  34. Chaves LL; Vieira AC; Reis S; Sarmento B; Ferreira DC. "Quality by design: discussing and assessing the solid dispersions risk.". (2014): http://europepmc.org/abstract/med/24517867.
    10.2174/1567201811666140211110943
  35. Nascimento, A.V.; Singh, A.; Bousbaa, H.; Ferreira, D.; Sarmento, B.; Amiji, M.M.. "Mad2 checkpoint gene silencing using epidermal growth factor receptor-targeted chitosan nanoparticles in non-small cell lung cancer model". Molecular Pharmaceutics 11 10 (2014): 3515-3527. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908009342&partnerID=MN8TOARS.
    10.1021/mp5002894
  36. Nunes da Silva, M.; Cardoso, A.R.; Ferreira, D.; Brito, M.; Pintado, M.E.; Vasconcelos, M.W.. "Chitosan as a biocontrol agent against the pinewood nematode (Bursaphelenchus xylophilus)". Forest Pathology 44 5 (2014): 420-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907951496&partnerID=MN8TOARS.
    10.1111/efp.12136
  37. Gomes MJ; Martins S; Ferreira D; Segundo MA; Reis S. "Lipid nanoparticles for topical and transdermal application for alopecia treatment: development, physicochemical characterization, and in vitro release and penetration studies.". (2014): http://europepmc.org/abstract/med/24634584.
    10.2147/IJN.S45561
  38. Soares S; Fonte P; Costa A; Andrade J; Seabra V; Ferreira D; Reis S; Sarmento B. "Effect of freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin-loaded solid lipid nanoparticles.". (2013): http://europepmc.org/abstract/med/24036086.
    10.1016/j.ijpharm.2013.08.076
  39. Andrade F; Rafael D; Videira M; Ferreira D; Sosnik A; Sarmento B. "Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases.". (2013): http://europepmc.org/abstract/med/23932923.
    10.1016/j.addr.2013.07.020
  40. Martins SM; Sarmento B; Nunes C; Lúcio M; Reis S; Ferreira DC. "Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration.". (2013): http://europepmc.org/abstract/med/23994244.
    10.1016/j.ejpb.2013.08.011
  41. Moretton MA; Chiappetta DA; Andrade F; das Neves J; Ferreira D; Sarmento B; Sosnik A. "Hydrolyzed galactomannan-modified nanoparticles and flower-like polymeric micelles for the active targeting of rifampicin to macrophages.". (2013): http://europepmc.org/abstract/med/23858973.
    10.1166/jbn.2013.1600
  42. Antunes F; Andrade F; Araújo F; Ferreira D; Sarmento B. "Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs.". (2013): http://europepmc.org/abstract/med/23159710.
    10.1016/j.ejpb.2012.10.003
  43. Antunes F; Andrade F; Ferreira D; Nielsen HM; Sarmento B. "Models to predict intestinal absorption of therapeutic peptides and proteins.". (2013): http://europepmc.org/abstract/med/21933113.
    10.2174/138920013804545160
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  51. Silva AC; Amaral MH; González-Mira E; Santos D; Ferreira D. "Solid lipid nanoparticles (SLN)--based hydrogels as potential carriers for oral transmucosal delivery of risperidone: preparation and characterization studies.". (2012): http://europepmc.org/abstract/med/22293602.
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  52. Martins S; Tho I; Souto E; Ferreira D; Brandl M. "Multivariate design for the evaluation of lipid and surfactant composition effect for optimisation of lipid nanoparticles.". (2012): http://europepmc.org/abstract/med/22245538.
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  53. Detoni CB; de Oliveira DM; Santo IE; Pedro AS; El-Bacha R; da Silva Velozo E; Ferreira D; Sarmento B; de Magalhães Cabral-Albuquerque EC. "Evaluation of thermal-oxidative stability and antiglioma activity of Zanthoxylum tingoassuiba essential oil entrapped into multi- and unilamellar liposomes.". (2012): http://europepmc.org/abstract/med/21548711.
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  54. Martins SM; Wendling T; Gonçalves VM; Sarmento B; Ferreira DC. "Development and validation of a simple reversed-phase HPLC method for the determination of camptothecin in animal organs following administration in solid lipid nanoparticles.". (2012): http://europepmc.org/abstract/med/22153332.
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  55. Silva AC; Santos D; Ferreira D; Lopes CM. "Lipid-based nanocarriers as an alternative for oral delivery of poorly water- soluble drugs: peroral and mucosal routes.". (2012): http://europepmc.org/abstract/med/22834821.
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  56. Silva, A.C.; Lopes, C.M.; Fonsecaa, J.; Soares, M.E.; Santos, D.; Souto, E.B.; Ferreira, D.. "Risperidone release from Solid Lipid Nanoparticles (SLN): Validated HPLC method and modelling kinetic profile". Current Pharmaceutical Analysis 8 4 (2012): 307-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857786253&partnerID=MN8TOARS.
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  57. Andrade F; Antunes F; Nascimento AV; da Silva SB; das Neves J; Ferreira D; Sarmento B. "Chitosan formulations as carriers for therapeutic proteins.". (2011): http://europepmc.org/abstract/med/21091431.
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  60. Fonte, P.; Nogueira, T.; Gehm, C.; Ferreira, D.; Sarmento, B.. "Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin". Drug Delivery and Translational Research 1 4 (2011): 299-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857786020&partnerID=MN8TOARS.
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  67. Sarmento B; Ribeiro A; Veiga F; Sampaio P; Neufeld R; Ferreira D. "Alginate/chitosan nanoparticles are effective for oral insulin delivery.". (2007): http://europepmc.org/abstract/med/17577641.
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  68. Sarmento B; Ribeiro A; Veiga F; Ferreira D; Neufeld R. "Oral bioavailability of insulin contained in polysaccharide nanoparticles.". (2007): http://europepmc.org/abstract/med/17877397.
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  69. Ribeiro LS; Falcão AC; Patrício JA; Ferreira DC; Veiga FJ. "Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimize the oral bioavailability of vinpocetine.". (2007): http://europepmc.org/abstract/med/17530626.
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  70. Sarmento B; Ribeiro AJ; Veiga F; Ferreira DC; Neufeld RJ. "Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation.". (2007): http://europepmc.org/abstract/med/17685304.
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  71. Sarmento B; Ferreira DC; Jorgensen L; van de Weert M. "Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles.". (2007): http://europepmc.org/abstract/med/17101268.
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  72. Sarmento B; Martins S; Ferreira D; Souto EB. "Oral insulin delivery by means of solid lipid nanoparticles.". (2007): http://europepmc.org/abstract/med/18203440.
  73. Martins S; Sarmento B; Ferreira DC; Souto EB. "Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles.". (2007): http://europepmc.org/abstract/med/18203427.
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  77. Sarmento, B.; Martins, S.; Ferreira, D.; Souto, E.B.. "Oral insulin delivery by means of solid lipid nanoparticles". International Journal of Nanomedicine 2 4 (2007): 743-749. http://www.scopus.com/inward/record.url?eid=2-s2.0-41849134910&partnerID=MN8TOARS.
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  117. Ferreira, D.C.; Prista, L.V.N.; Morgado, R.M.R.; Lobo, J.M.S.. "Sustained release oxazepam tablets,COMPRIMIDOS DE ACCAO PROLONGADA CONTENDO OXAZEPAM". Revista Portuguesa de Farmacia 42 1 (1992): 31-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026645279&partnerID=MN8TOARS.
  118. Carvalho Ferreira, D.; Nogueira Prista, L.V.; Ramos Morgado, R.M.; Sousa Lobo, J.M.. "The stability of lorazepam solutions: II. The influence of solvents,ESTABILIDADE DO LORAZEPAM EM SOLUCOES AQUOSAS: II. INFLUENCIA DO SOLVENTE". Revista Portuguesa de Farmacia 42 2 (1992): 19-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026714925&partnerID=MN8TOARS.
  119. Ferreira, D.C.; Prista, L.V.N.; Morgado, R.M.R.; Lobo, J.M.S.. "The stability of lorazepam in aqueous solutions: I. The influence of pH,ESTABILIDADE DO LORAZEPAM EM SOLUCOES AQUOSAS: I - INFLUENCIA DO PH". Revista Portuguesa de Farmacia 42 1 (1992): 26-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026654703&partnerID=MN8TOARS.
  120. Ferreira, D.C.; Prista, L.V.N.; Morgado, R.M.R.; Lobo, J.M.S.. "The stability of lorazepam in aqueous solutions. III. The influence of surfactants,ESTABILIDADE DO LORAZEPAM EM SOLUCOES AQUOSAS: III - INFLUENCIA DOS TENSIOACTIVOS". Revista Portuguesa de Farmacia 42 3 (1992): 34-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026485355&partnerID=MN8TOARS.
  121. Carvalho Ferreira, D.; Guedes Bahia, M.F.; Nogueira Prista, L.N.; Cancelo Carrilho, A.N.. "Effect of sodium lauryl sulfate on the partitioning of lorazepam in 1-octanol/water,EFEITO DO SULFATO DE LAURILO E SODIO NA PARTILHA DO LORAZEPAM EM 1-OCTANOL/AGUA". Anales de la Real Academia de Farmacia 57 4 (1991): 595-602. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026324184&partnerID=MN8TOARS.
  122. Carvalho Ferreira, D.; Nogueira Prista, L.V.; Ramos Morgado, R.M.; Cancelo Carrilho, A.P.. "Determination of the dielectric requirement and the solubility parameter of 1,4-benzodiazepines". Anales de la Real Academia de Farmacia 56 4 (1990): 493-501. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025652803&partnerID=MN8TOARS.
Capítulo de livro
  1. Marques, Joana Moreira; Nunes, Rute; Florindo, Helena; Ferreira, Domingos; Sarmento, Bruno. "A demanding path from iPSCs toward pancreatic ß- and a-cells". In Recent Advances in iPSC-Derived Cell Types, 227-256. Elsevier, 2021.
    10.1016/b978-0-12-822230-0.00002-8
Livro
  1. Vasconcelos, T.; da Silva, S.B.; Ferreira, D.; Pintado, M.; Marques, S.. Cell-based in vitro models for ocular permeability studies. 2016.
  2. Da Silva, S.B.; Borges, S.; Ramos, Ó.; Pintado, M.; Ferreira, D.; Sarmento, B.. Treating retinopathies - Nanotechnology as a tool in protecting antioxidants agents. 2012.
    10.1007/978-3-642-30018-9_158
  3. Sarmento, B.; Ferreira, D.; Vasconcelos, T.. Polymer-Based Delivery Systems for Oral Delivery of Peptides and Proteins. 2009.
    10.1002/9780470688397.ch11
  4. Martins, S.; Ferreira, D.C.; Souto, E.B.. Lipid Nanoparticle-Based Systems for Delivery of Biomacromolecule Therapeutics. 2009.
    10.1002/9780470688397.ch7
Poster em conferência
  1. Marques, Joana Moreira; Nunes, Rute; Florindo, Helena; Ferreira, Domingos; Sarmento, Bruno. "Bioengineered glucose-responsive nanoparticles in artificial pancreas for Diabetes therapy". Trabalho apresentado em XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  2. Moreira Marques, Joana; Nunes, Rute; Florindo, Helena; Ferreira, Domingos; Sarmento, Bruno. "NanoIntelligent bioartificial pancreas for Diabetes therapy". Trabalho apresentado em 47th Annual Meeting of the Controlled Release Society (Virtual), 2020.
  3. Marques, Joana Moreira; Nunes, Rute; Florindo, Helena; Ferreira, Domingos; Sarmento, Bruno. "Glucose-responsive nanoparticles embedded in a 3D-engineered pancreas". Trabalho apresentado em Training School on Advanced spectroscopic analytical methods and new technologies in drug delivery, 2019.
  4. Moreira Marques, Joana; Nunes, Rute; Florindo, Helena; Ferreira, Domingos; Sarmento, Bruno. "Stimuli-responsive nanoparticles for pancreas mimetic construct". Trabalho apresentado em 8th i3S Annual Meeting, 2019.
  5. Moreira Marques, Joana; Nunes, Rute; Florindo, Helena; Ferreira, Domingos; Sarmento, Bruno. "Multifunctional stimuli-responsive pancreas mimetic". Trabalho apresentado em 2nd PhDay - PhD countdown: a time for Science - i3S, 2019.
  6. Pinheiro, Marina; Vieira, Alexandre; Lopes, Luíse; Ferreira, Domingos; Sarmento, Bruno; Reis, Salette. "Application of experimental design as optimization strategy in the development of nanoparticles as drug delivery systems for poorly soluble drugs as dapsone". Trabalho apresentado em Encontro Galego Português de Química, 2015.
  7. Pinheiro, Marina; Vieira, Alexandre; Lopes, Luíse; Ferreira, Domingos; Sarmento, Bruno; Reis, Salette. "Dual Site-Specific and Ph-Sensitive Drug Delivery System for the Improvement of the Pulmonary Tubercolosis Treatment". Trabalho apresentado em AAPS Annual Meeting and Exposition, 2015.
  8. Pinheiro, Marina; Vieira, Alexandre; Lopes, Luíse; Ferreira, Domingos; Sarmento, Bruno; Reis, Salette. "Development of solid lipid nanoparticles of dapsone as a novel drug release system against mycobacterium leprae". Trabalho apresentado em XXIV Encontro Nacional da Sociedade Portuguesa de Química, 2015.
  9. Pinheiro, Marina; Vieira, Alexandre; Lopes, Luíse; Ferreira, Domingos; Sarmento, Bruno; Reis, Salette. "Application of drug delivery systems for treatment of pulmonary tuberculosis". Trabalho apresentado em Bio Engineering Conference¿14, 2014.
  10. Marques, Claudia; Bárbara B. Mendes; Azevedo, A. R.; Costa, Paulo; Martins, Susana; Sarmento, Bruno; Ferreira, Domingos. "Drug loaded-lipid nanoparticles as carriers for drug delivery to glioma using an in vitro blood brain barrier model.". Trabalho apresentado em 11th International Conference on Nanosciences & Nanotechnologies, 2014.
  11. Marques, Claudia; Mendes, Bárbara; Azevedo, Ana Rita; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Drug loaded-lipid nanoparticles as carriers for drug delivery to gliomas using an in vitro blood brain barrier model". Trabalho apresentado em 11th International Conference on Nanosciences & Nanotechnologies (NN14), 2014.
  12. Mendes, Bárbara; Marques, Claudia; Martins, Susana; Costa, Paulo; Ferreira, Domingos; Sarmento, Bruno. "Development of an in vitro Blood-Brain Barrier model for drug-loaded solid lipid nanoparticles delivery". Trabalho apresentado em 5th International Conference on Advanced Nanomaterials (ANM2014), 2014.
  13. Mendes, Bárbara; Marques, Claudia; Costa, Paulo; Ferreira, Domingos; Sarmento, Bruno. "Development and characterization of a co-culture two-dimensional blood-brain barrier for the study and correlation of drug permeation". Trabalho apresentado em 7.º Encontro Investigação Jovem da Universidade do Porto, 2014.
Resumo em conferência
  1. Pinheiro, Sara; Pinto, Soraia; Magalhães, Joana; Chaves, Luíse L.; Vieira, Alexandre C.C.; Pinheiro, Marina; Ferreira, Domingos; Sarmento, Bruno; Reis, Salette. "Solid lipid nanoparticles for specific delivery of rifampicin to alveolar macrophages". Trabalho apresentado em 9º Encontro de Investigação Jovem da Universidade do Porto, Porto, 2016.
    Publicado

Outros

Outra produção
  1. Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies. 2006. Sarmento B; Ferreira D; Veiga F; Ribeiro A. http://europepmc.org/abstract/AGR/IND43853742.
    10.1016/j.carbpol.2006.02.008
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019 - Atual Synergic approach to the treatment of glioblastoma through a novel xanthone-polymersome system
Orientador de Ana daniela Coutinho Alves
Universidade do Porto Faculdade de Farmácia, Portugal
2018 - Atual Multistage pancreas biomimetic construct based on synergism of functionalized nanomedicines and cell differentiation
Coorientador de Joana Beatriz Antunes Moreira Carvalho Marques
Universidade do Porto Faculdade de Farmácia, Portugal
2018 - Atual Discovery of Multitargeting small-mollecules against cancer-related imunossupressive players
Coorientador de Carlota Miguel Leonardo de Sousa
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - Atual Desenvolvimento de um sistema bucal de libertação prolongada para o tratamento paliativo de mucosite oral induzida por tratamentos oncológicos
Coorientador de João Costa Campos
Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2017 Orphans drugs: A regulatory, Ethical and Pharmacoeconomic framework
Orientador de Flávia Patrícia Ribeiro Moreira
Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2017 Development of a proliposome formulation as a drug carrier for a novel antitumor drug
Coorientador de Ana Daniela Coutinho Alves
Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2017 In vitro/in vivo correlation of peguilated lipid nanoparticles for intravenous administration of daptomycin
Coorientador de Alexandre Couto Carneiro Vieira
Universidade do Porto Faculdade de Farmácia, Portugal
2013 - 2017 New technologies for the improvement of leprosy multidrug therapy: a quality by design approach
Orientador de Luíse Lopes Chaves
Universidade do Porto Faculdade de Farmácia, Portugal
2012 - 2016 Innovative functional polymer therapeutic nano technologies for isRNA delivery in lung câncer
Coorientador de Ana Vanessa Hortas do Nascimento
Universidade do Porto Faculdade de Farmácia, Portugal
2012 - 2016 Synthesis of Locust Bean Gum new derivates and their application in nanoparticulate drug delivery systems
Coorientador
Universidade do Porto Faculdade de Farmácia, Portugal
2013 - 2015 Production of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) containing antitumoral drug (saquinavir)
Coorientador de Ana Rita dos Santos Azevedo
2013 - 2015 Desenvolvimento de prolipossomas com paclitaxel: uma nova abordagem na terapia do cancro
Orientador
2013 - 2015 Development of proliposomes as a vehicle to deliver new molecules with antitumor activity
Orientador de Ana Rita Silva Moreira
Universidade do Porto Faculdade de Farmácia, Portugal
2011 - 2015 Glucose-sensitive nanocarriers for ccontrolled pulmonar administration of insulin contained into polymeric micelles
Coorientador de Fernanda Raquel da Silva Andrade
Universidade do Porto Faculdade de Farmácia, Portugal
2012 - 2014 Development of Oral Tablets Containing Nicorandil
Orientador de Miguel António Pires de Matos
Universidade do Porto Faculdade de Farmácia, Portugal
2012 - 2014 “Development and characterization of a co-cultuure two-dimensional blood-brain barrier for the study and correlation of drug permeation
Orientador de Bárbara Bruna da Silva Mendes
2010 - 2014 Antioxidant containing chitosan nanomedicines for the prevention and treat of Diabetic Retinopathy
Coorientador de Sara Isabel Macedo Baptista da Silva
2008 - 2012 Drug delivery across blood-brain-barrier by means of IV administration of lipid nanoparticles
Orientador de Susana Amélia Marques Martins
Universidade do Porto Faculdade de Farmácia, Portugal
2008 - 2012 “Development of a novel oral lipid-based carrier for hormone delivery
Orientador de Ana Catarina da Cruz Rodrigues da Silva
Universidade do Porto Faculdade de Farmácia, Portugal
2008 - 2010 A process analytical technology approach based on spectroscopic techniques and multivariate data analysis: quantifying ternary mixtures of amlodipine besylate solid forms
Orientador de Ana Filipa Fontelonga de Lemos
Universidade do Porto Faculdade de Farmácia, Portugal
2006 - 2008 Estudo de libertação do buflomedil piridoxal fosfato (BPP) a partir de sistemas matriciais
Orientador de Pedro Pedro Miguel da Costa Barrocas
Universidade do Porto Faculdade de Farmácia, Portugal
2004 - 2008 Desenvolvimento de formulações de libertação modificada de ranitidina
Coorientador de Pedro Miguel Barata da Silva Coelho
2004 - 2008 Desenvolvimento, formulação e avaliação de sistemas de libertação transdémica incorporando sistemas ternários de complexação (fármaco/ciclodextrina/polímero)
Coorientador de Rita Sanches Oliveira
Universidade do Porto Faculdade de Farmácia, Portugal
2003 - 2007 Improvement of peptidic drugs oral availability through their encapsulation in polyelectrolytes complexes
Orientador de Bruno Filipe Carmelino Sarmento
Universidade do Porto Faculdade de Farmácia, Portugal
2002 - 2005 Aumento da biodisponibilidade oral de fármacos peptídeos recorrendo à encapsulação em alginato e quitosano
Coorientador de Catarina Isabel de Bulhão Pato Mendes da Silva
Universidade de Coimbra Faculdade de Farmácia, Portugal
2000 - 2005 Sistemas multicomponentes com ciclodextrinas como estratégia para optimizar a biodisponibilidade de fármacos – Aplicação em medicamentos de libertação controlada
Orientador de Laura Sofia dos Santos Ribeiro
Universidade de Coimbra Faculdade de Farmácia, Portugal
2001 - 2003 Preparações para inalação – Avaliação aerodinâmica das partículas finas
Orientador de Carla Isabel Amante Carlos
Universidade do Porto Faculdade de Farmácia, Portugal
2001 - 2003 Modulação da libertação de teofilina a partir de comprimidos matriciais carboméricos
Coorientador de Pedro Miguel Barata da Silva Coelho
Universidade do Porto Faculdade de Farmácia, Portugal
1998 - 2003 Modulation transfer of drugs. Effect of the drug release characteristics models
Coorientador de Maria Helena dos Anjos Rodrigues Amaral
Universidade do Porto Faculdade de Farmácia, Portugal
1995 - 1997 Formulação de comprimidos contendo piroxicam
Orientador de Angélica Cristiane Moreira
Universidade do Porto Faculdade de Farmácia, Portugal