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Joana FM Pires has both a BSc. Biomedical Science (since 2018) and MSc. (since 2018) degree in Molecular Biomedicine from Faculty of Medical Sciences of University of Aveiro. During her undergraduate studies, she became curious in studying how different organisms have different behaviors and levels of cognition. Therefore, she developed her Master Thesis in cooperation with the European Neuroscience Institute (ENI) - A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society under the supervision of Dr. Ira Milosevic. There, she was characterized the expression and localization of amisyn (STXBP6) in the different brain areas during mouse lifespan, using an optimized confocal acquisition technique of sagittal brain slices. This work helped in the characterization of functional and biological roles of this protein during exocytosis, as well as its variation at different developmental stages and how this impacts the SNARE complex. During her academic carrer and through competitive evaluation, she gained two Erasmus Scholarships, which allow her to develop scientific work in an early career stage, thus gaining solid knowledge in international laboratories. She also obtained a Master Research Fellow (MindGAP H2020/FET-Open project) in the field of Biomaterials at Biomark@UC to develop a novel portable biosensor device able to capture brain extracellular vesicles involved in mind/body interactions. This work resulted in an oral presentation at the ISEV2021 Annual Meeting. Joana FM Pires also involved in several in volunteer programs with children at the university hospital and in the organization and participation of scientific conference cycles. Recently she has been involved in science communication projects for non-specialised people, as the national coordinator of the Coimbra district of the international science festival "Pint of Science". Currently, she is a Master’s Research assistant at the Multidisciplinary Institute of Aging (MIA-Portugal), her research focus is to understand the molecular and cellular mechanisms/processes in neuronal metabolism that lead to increased disease susceptibility, collaborating in several research projects supported by start-up funds from MIA-Portugal (an H2020-funded Teaming project), two FCT projects and one ERC-Portugal award from FCT of Dr. Nuno Raimundo. Currently, had developed a series of advanced laboratory and management methodologies, that allow it to perform research with a high standard of scientific rigour. She is also co-author of a original article at Book Chapter in Aging: From Fundamental Biology to Societal Impact (doi:10.1016/c2020-0-00576-1) demonstrating her knowledge in the field. She also participated as second author in a review article on the role of lipids in the interaction between mitochondria and other cell organelles (revised and submitted to Trends in Cell Biology), and as third author in a research article on the role of lipids in the nuclear envelope in DNA repair (submitted to Cell). Joana Pires attended and presented her work at several national and international scientific meetings (e.g., selected poster presentation sessions - 3rd RESETageing Conference (2023), 2nd MIA Ageing Spring School (2024); was part of the organizing committee of MIA-Spring School 2022/2023 and was awarded with a participation and travel grant for the 22nd International Symposium on Chromaffin Cell Biology (2024). Joana Pires, has experience in molecular techniques (e.g. Western Blotting, qPCR, PCR) immunohistochemistry and immunofluorescence, as well as maintenance and manipulation of model organisms (e.g. mice). Moreover, she has expertise in isolation and culture of (i) whole brain samples (in mice) and (ii) primary cellular cultures of both cortical areas (in mice). She has a vast knowledge in mitochondrial characterization, confocal imaging as well as data treatment (GraphPad) and video and image analysis (ImageJ and Adobe Photoshop).
Identificação

Identificação pessoal

Nome completo
Joana Filipa Mariano Pires

Identificadores de autor

Ciência ID
201F-B779-DEA5

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2024/09/03 - 2024/09/13
Concluído
Summer School in Computational Biology (Outros)
Universidade de Coimbra, Portugal
2022/11/15 - 2023/02/17
Concluído
Laboratory Animal Science course (Function A & SS) (Outros)
Especialização em Function A + Modules 20, 21 and 22 - Equivalent to FELASA B training
Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2021/07/02 - 2021/07/29
Concluído
Cell Culture and Tissue Training Course (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/10/02 - 2020/11/19
Concluído
Clinical Investigator Certification Level 1 (Outros)
Universidade de Aveiro Associação para a Formação Profissional e Investigação, Portugal
2018/09/17 - 2020/07/14
Concluído
Molecular Biomedicine (Mestrado)
Especialização em Neuroscience, Molecular Biology
Universidade de Aveiro, Portugal
"Characterization of amisyn expression and localization in the brain over mouse lifespan" (TESE/DISSERTAÇÃO)
17
2015/09/19 - 2018/07/30
Concluído
Biomedical Science (Licenciatura)
Universidade da Beira Interior, Portugal
"Laser application in the treatment of Benign Prostatic Hyperplasia" (TESE/DISSERTAÇÃO)
13
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2021/12/15 - Atual Assistente de Investigação (carreira) (Investigação) Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2020/12/15 - 2021/12/15 Investigador (Investigação) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
BioMark Sensor Research, Universidade de Coimbra - , Portugal
2019/09/01 - 2020/02/29 Estagiário de Investigação (Investigação) Europäisches Neurowissenschaftliches Institut Göttingen, Alemanha
Universitätsmedizin Göttingen, Alemanha
2017/07 - 2017/09 Estagiário de Investigação (Investigação) Instituto de Biomedicina de Sevilla, Espanha
Instituto de Biomedicina de Sevilla, Espanha
Projetos

Bolsa

Designação Financiadores
2020/12/15 - 2021/12/15 MindGAP - Bridging the gap between Mind, Brain and Body: exosome role and monitoring (GA829040)
Bolseiro de Investigação
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
EU Framework Programme for Research and Innovation Euratom
Em curso
2019/09/01 - 2020/01/31 Characterization of amisyn expression and localization in the brain over mouse lifespan
Bolseiro de Mestrado
Europäisches Neurowissenschaftliches Institut Göttingen, Alemanha
Concluído

Projeto

Designação Financiadores
2023/03/01 - 2024/08/31 Different intracellular AMPK pools modulate mitochondria-ER contact sites
2022.04407.PTDC
Investigador
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso

Outro

Designação Financiadores
2017/07/13 - 2017/09/13 New therapeutic alternatives to treat adenovirus infections
USE-13901-D
Bolseiro de Iniciação Científica
Universidad de León Instituto de Biomedicina, Espanha
Concluído
Produções

Publicações

Artigo em revista
  1. Domingues, Neuza; Joana F. Pires; Milosevic, Ira; Raimundo, Nuno. "Role of lipids in inter-organelle communication". Trends in Cell Biology (2024):
    No prelo
Capítulo de livro
  1. Carvalho, Cristina; Pires, Joana; Paula I. Moreira; Raimundo, Nuno. "Disrupted cellular quality control mechanisms in aging". In Aging From Fundamental Biology to Societal Impact, editado por Paulo J. Oliveira; João O. Malva. Portugal: Elsevier, 2022.
    Publicado • 10.1016/c2020-0-00576-1
Poster em conferência
  1. Joana F. Pires; Jialin Jin; Milosevic, Ira. "Amisyn expression and distribution in the mammalian aged brains". Trabalho apresentado em RESETageing conference 2023, 2023.
  2. Domingues, Neuza; Joana F. Pires; Raimundo, Nuno. Autor correspondente: Raimundo, Nuno. "Unveiling the molecular mechanisms of Batten disease in the absence of CLN3". Trabalho apresentado em Gordon Research Conference Lysosomal Diseases, 2023.
Pré-impressão
  1. Domingues, Neuza; Calcagni’, Alessia; Pires, Joana; Freire, Sofia Roque; Herz, Niculin Joachim; Huynh, Tuong; Wieciorek, Katarzyna; et al. "Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling". 2024. http://dx.doi.org/10.1101/2024.05.31.596474.
    10.1101/2024.05.31.596474
Resumo em conferência
  1. Manuela Maria Teixeira Basto de Faria Frasco; Mariana Amorim ; Joana F. Pires; Maria Goreti Ferreira Sales. "Plastic antibodies tailored as photonic materials for sensing extracellular vesicles". Trabalho apresentado em ISEV2022, Journal of Extracellular Vesicles, 2022.
    Publicado • 10.1002/jev2.12224
Tese / Dissertação
  1. "Characterization of amisyn expression and localization in the brain over mouse lifespan". Mestrado, Universidade de Aveiro Departamento de Ciências Médicas, 2020. https://ria.ua.pt/handle/10773/29008.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/05/30 Characterization of amisyn expression and localization in the brain over mouse lifespan "Weekly @CNC" Seminar
(Coimbra, Portugal)
2023/05/13 Unveiling the molecular mechanisms of Batten disease in the absence of CLN3 Gordon Research Conference (GRC) 2023
GRC Frontiers of Science Fund (Barcelona, Espanha)
2022/05/26 Plastic antibodies adapted as photonic materials for detection of extracellular vesicles. ISEV 2022 meeting
International Society for Extracellular Vesicles (Lyon, França)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2023/09/29 - 2023/09/29 2023 European Researchers' Night (2023/09/29 - 2023/09/29)
Oficina (workshop) (Membro da Comissão Científica)
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2022/10 - 2022/10 FIC.A - Festival Internacional de Ciência 2022 (2022/10 - 2022/10) (2022/10 - 2022/10) Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2022/09/30 - 2022/09/30 2022 European Researchers' Night (2022/09/30 - 2022/09/30)
Oficina (workshop) (Membro da Comissão Organizadora)
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2022/04/04 - 2022/04/08 Ageing Spring School 2022 (2022/04/04 - 2022/04/08) (2022/04/04 - 2022/04/08)
Conferência
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2017/03/08 - 2017/03/11 Participation in the organization of the event "VIII National Biomedical Sciences Conference". The Journeys consist in the debate of themes inherent to biomedical research in Portugal and of the scientific community. The lectures focus on areas such as Biomaterials, Bioinformatics, Instrumentation, Neuroscience, Forensic Sciences, with prestigious names of Portuguese science. (2017/03/08 - 2017/03/11)
Conferência (Outra)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2024/08/01 - 2024/08/01 Dissemination of science by the University of Coimbra in the Education Space at Expofacic in Cantanhede, offering interactive activities for all ages, with a special focus on young people.
Outro
EXPOFACIC | Atelier da Ciência UC, MIA-Portugal
Universidade de Coimbra, Portugal
2024/02/07 - 2024/02/07 SEMANA DA CIÊNCIA UC, Escola Secundária Artur Gonçalves de Torres Novas, promoted by the University of Coimbra. The activity comprised the ecomprised a lecture/introduction and hands-on on the genetics of aging, with the participation of high-school students.
Universidade de Coimbra, Portugal
2023/12/04 - 2023/12/07 EIT Health Ageing PhD School Annual Retreat 2023
Encontro
EIT Health Ageing PhD School Annual Retreat 2023
EIT Health, Alemanha
2021/06/29 - 2021/06/29 8th Biotech Health Annual Symposium: Biotech Talks | The Future is Now
Simpósio
8th BiotechHealth Annual Symposium, “Biotech Talks | The Future is Now”
Universidade do Porto, Portugal
2018/11/20 - 2018/11/20 Participation in conference "Signalling Afternoon" whose main focus was the debate on cell signaling pathways and their fundamental role in the processes of proliferation, growth, differentiation and cell death.
Conferência
Signalling Afternoon
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/07/05 - 2018/07/06 Participation "XII Annual CICS-UBI Symposium" whose main objective was to make known the research being carried out at the Health Sciences Research Centre in the fields of biomedical, biotechnological and drug development research, diagnosis, omonitoring and treatment of diseases existing in modern societies.
Simpósio
XII Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/02/23 - 2018/02/23 Participation in the "I Encontro das Tecnologias da Saude da CHCB" promoted by the Technical Council of Diagnosis and Therapy of the CHCB intends to share knowledge and experiences among all Health Technicians in the areas of diagnosis and therapy, intervenient in diagnosis and research. The central theme of this meeting was entitled "Evaluate, Diagnose and Treat".
Encontro
I Encontro das Tecnologias da Saude da CHCB - Evaluate, Diagnose and Treat
Centro Hospitalar Cova da Beira EPE, Portugal
2018 - 2018 Participation in a children's volunteer project - "Hospital da Faz de Conta" Faculty of Health Sciences, UBI(2018) that helped me develop capacities such as solidarity, responsibility and communication with children.
Encontro
Hospital Faz de Conta
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2017 - 2018 Participation in a children's volunteer project - "Canto da Cigarra" Cova da Beira Hospital Center, (Covilhã) which aims to humanize the hospital space by providing psychosocial well-being to children under 12 years of age.
Encontro
Canto da Cigarra
Centro Hospitalar Cova da Beira EPE, Portugal
2016/11/09 - 2016/11/30 Participation in the "II Cycle of Biomedical Conferences in the Afternoon" where researchers from different areas expose the research that is being done in Biotechnology, Reproduction Biology, Medical Devices/Biosensors, Biomaterials, Neurophysiology, Oncobiology, Entrepreneurship and Medical Imaging.
Conferência
II Cycle of Biomedical Conferences in the Afternoon
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2021/10 - 2023/05 She is the coordinator of Coimbra Pint of Science - an international science festival that makes scientific discussion accessible to the whole population in order to bridge the communication gap that exists in this area.
Coordenador

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023/06/14 - Atual International Journal of Biochemistry and Cell Biology (1357-2725)
Distinções

Prémio

2024 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2023 Travel Award to participate in 22nd International Symposium on Chromaffin Cell Biology 2024