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Gil Castro began his scientific career at the Center for Experimental Cytology, University of Porto (1988 – 1994), where he did is PhD. As a postdoctoral researcher he moved to DNAX Research Institute, Palo Alto, CA,USA (1995 – 1998). He then moved to the Gulbenkian Institute for Science (1998 – 2000) to gain knowledge on molecular biology. He then moved to the Institute for Life and Health Sciences, University of Minho (2002 – present). This allowed him to focus his investigation on the immunological mechanism underlying protective/pathologic immune responses to M. tuberculosis. He has published 90 articles in specialized journals. He has received 10 awards and/or honors. He participates and/or participated in 11 projects, 5 of which as a principal investigator. He has already trained more than 30 students between masters and doctoral students.
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Identificação

Identificação pessoal

Nome completo
António Gil Pereira de Castro

Nomes de citação

  • Castro, Gil

Identificadores de autor

Ciência ID
2B14-A625-4C4A
ORCID iD
0000-0002-4684-4183

Telefones

Telefone
  • 253604815 Ext.: 604815 (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
1996
Concluído
 Biologia (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Faculdade de Ciências, Portugal
"Citocinas e Regulação da Imunidade Natural e Adquirida na Infecção Experimental do Ratinho por Mycobacterium Avium" (TESE/DISSERTAÇÃO)
1982 - 1987
Concluído
 Biologia (Licenciatura)
Especialização em Cientifico
Universidade do Porto Faculdade de Ciências, Portugal
 13
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2003/01/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003 - Atual Investigador principal (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Medicina, Portugal
(...)
2000/09/01 - 2002/07/31 Investigador (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2008 - Atual Professor Associado (Docente Universitário) Universidade do Minho, Portugal
2002/09/04 - 2008/03/01 Professor Auxiliar (Docente Universitário) Universidade do Minho, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/02/01 - Atual Conselho de escola Universidade do Minho Escola de Medicina, Portugal
2003/01/02 - 2020/03/02 Conselho científico/técnico-científico ou orgão correspondente Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
2011/02/01 - 2014/06/01 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade do Minho, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
1998/07/01 - 2000/07/31 Pos-Doc Instituto Gulbenkian de Ciência, Portugal
1995/01/06 - 1998/05/01 Pos-Doc Merck Research Laboratories Palo Alto, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2010 - 2013 BCG vaccination: a tool to identify new correlates of protection and pathology in experimental infection with Mycobacterium tuberculosis
PTDC/SAU-MII/101977/2008
Investigador responsável
Fundação para a Ciência e Tecnologia
2009 - 2012 Reconstitution and Homeostasis of the Immune System Following HIV-Infection
PIC/IC/83313/2007
Investigador responsável
Fundação para a Ciência e Tecnologia
2007 - 2010 Role of Interleukin-23 (IL-23) and IL-17 in the regulation of the immune response to the infection by Mycobacterium tuberculosis
PTDC/SAU-MII/70895/2006
Investigador responsável
Fundação para a Ciência e Tecnologia
2002 - 2004 The Immune Response to Allografts: Role of Anti-inflammatory Cytokines
POCTI/MGI/42345/2000
Investigador responsável
Fundação para a Ciência e Tecnologia

Projeto

Designação Financiadores
2018/06 - 2021/06 Immunological basis of failure in controlling Mycobacterium tuberculosis infection
PTDC/SAU-INF/28463/2017
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
2018 - 2021 Microbiota in cancer immunosurveillance: new avenues for immunotherapy
PTDC/MED-ONC/28658/2017
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Em curso
2017/06 - 2020/05 Immunometabolic Networks in the Regulation of Visceral Leishmaniasis
Infect-ERA/0001/2016
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
2014/03/31 - 2017 Deregulation of hematopoiesis by Interleukin-10 over-expression: implications for the development of hematological disorders
FCT-ANR/BIM-MEC/0007/2013
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Association Francophone Internationale de Recherche Scientifique en Éducation Portugal, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Concluído
2009/01/01 - 2012/01/01 Molecular mechanisms regulating the expression of IL-12 cytokines by Mycobacterium tuberculosis infected macrophages and dendritic cells.
PTDC/BIA-BCM/102776/2008
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluído
Produções

Publicações

Artigo em conferência
  1. Oliveira, J.T.; Picciochi, R.; Santos, T.C.; Malafaya, P.B.; Sousa, R.A.; Marques, A.P.; Castro, A.G.; et al. "Injectable gellan gum hydrogels as supports for cartilage tissue engineering applications: In vitro characterization and initial in vivo studies". 2008.
  2. Santos, T.C.; Tuzlakoglu, K.; Morton, T.; Reise, K.; Marques, A.P.; Castro, A.G.; Redl, H.; Reis, R.L.; Van Griensven, M.. "In vivo evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using adipose derived adult stem cells and transgenic mice". 2008.
Artigo em revista
  1. Marne Azarias-da-Silva; pierre nioche; Calaiselvy Soudaramourty; Anne Bull-Maurer; Mounira Tiouajni; kong dechuan; Ouafa Zghidi-Abouzid; et al. "Repetitive mRNA vaccination is required to improve the quality of broad-spectrum anti–SARS-CoV-2 antibodies in the absence of CXCL13". Science Advances (2023): http://dx.doi.org/10.1126/sciadv.adg2122.
    10.1126/sciadv.adg2122
  2. André Santa Cruz; Ana Mendes-Frias; Marne Azarias-da-Silva; Sónia André; Ana Isabel Oliveira; Olga Pires; Marta Mendes; et al. "Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+ß7 integrin+ T cells and anti-SARS-CoV-2 IgA response". Nature Communications (2023): http://dx.doi.org/10.1038/s41467-023-37368-1.
    10.1038/s41467-023-37368-1
  3. Paula Roberta Aguiar Pastrez; Ana Margarida Barbosa; Vânia Sammartino Mariano; Rhafaela Lima Causin; Antonio Gil Castro; Egídio Torrado; Longatto-Filho A. "Interleukin-8 and Interleukin-6 Are Biomarkers of Poor Prognosis in Esophageal Squamous Cell Carcinoma". Cancers (2023): http://dx.doi.org/10.3390/cancers15071997.
    10.3390/cancers15071997
  4. Daniel Barreira Rodrigues; Helena R. Moreira; Mariana T. Cerqueira; Alexandra P. Marques; António G. Castro; Rui L. Reis; R.P. Pirraco. "Highly tailorable gellan gum nanoparticles as a platform for the development of T cell activator systems". Biomaterials Research (2022): http://dx.doi.org/10.1186/s40824-022-00297-z.
    10.1186/s40824-022-00297-z
  5. Sonia André; Marne Azarias da Silva; Morgane Picard; Aurélie Alleaume-Buteau; Lucy Kundura; Renaud Cezar; Calaiselvy Soudaramourty; et al. "Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients". Cell Death & Disease (2022): http://dx.doi.org/10.1038/s41419-022-05190-0.
    10.1038/s41419-022-05190-0
  6. Catarina M. Ferreira; Consuelo Micheli; Palmira Barreira-Silva; Ana Margarida Barbosa; Mariana Resende; Manuel Vilanova; Ricardo Silvestre; et al. "IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection". Frontiers in Immunology (2022): http://dx.doi.org/10.3389/fimmu.2022.946181.
    10.3389/fimmu.2022.946181
  7. Alves, A.L.; Costa-Gouveia, J.; Vieira de Castro, J.; Sotelo, C.G.; Vázquez, J.A.; Pérez-Martín, R.I.; Torrado, E.; et al. "Study of the immunologic response of marine-derived collagen and gelatin extracts for tissue engineering applications". Acta Biomaterialia 141 (2022): 123-131. http://dx.doi.org/10.1016/j.actbio.2022.01.009.
    10.1016/j.actbio.2022.01.009
  8. André, Sonia; Picard, Morgane; Cezar, Renaud; Roux-Dalvai, Florence; Alleaume-Butaux, Aurélie; Soundaramourty, Calaiselvy; Cruz, André Santa; et al. "T cell apoptosis characterizes severe Covid-19 disease". Cell Death & Differentiation (2022): http://dx.doi.org/10.1038/s41418-022-00936-x.
    10.1038/s41418-022-00936-x
  9. "Immune System Efficiency in Cancer and the Microbiota Influence.". Pathobiology : journal of immunopathology, molecular and cellular biology (2021): https://doi.org/10.1159/000512326.
    10.1159/000512326
  10. Cardoso, A.; Martins, A.C.; Maceiras, A.R.; Liu, W.; Castro, I.; Castro, A.G.; Bandeira, A.; et al. "Interleukin-10 induces interferon-¿-dependent emergency myelopoiesis". Cell Reports 37 4 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85119977049&partnerID=MN8TOARS.
    10.1016/j.celrep.2021.109887
  11. Ferreira, C.M.; Barbosa, A.M.; Barreira-Silva, P.; Silvestre, R.; Cunha, C.; Carvalho, A.; Rodrigues, F.; et al. "Early IL-10 promotes vasculatureassociated CD4+ T cells unable to control Mycobacterium tuberculosis infection". JCI Insight 6 21 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118899876&partnerID=MN8TOARS.
    10.1172/jci.insight.150060
  12. Zamboni, F.; Cengiz, I.F.; Barbosa, A.M.; Castro, A.G.; Reis, R.L.; Oliveira, J.M.; Collins, M.N.. "Towards the development of a female animal model of t1dm using hyaluronic acid nanocoated cell transplantation: Refinements and considerations for future protocols". Pharmaceutics 13 11 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85119622614&partnerID=MN8TOARS.
    10.3390/pharmaceutics13111925
  13. Barbosa, A.M.; Martinho, O.; Nogueira, R.; Campos, J.; Lobo, L.; Pinto, H.; Longatto-Filho, A.; et al. "Increased cd3+, cd8+, or foxp3+ t lymphocyte infiltrations are associated with the pathogenesis of colorectal cancer but not with the overall survival of patients". Biology 10 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85113948564&partnerID=MN8TOARS.
    10.3390/biology10080808
  14. Santa Cruz, A.; Mendes-Frias, A.; Oliveira, A.I.; Dias, L.; Matos, A.R.; Carvalho, A.; Capela, C.; et al. "Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia". Frontiers in Immunology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102130540&partnerID=MN8TOARS.
    10.3389/fimmu.2021.613422
  15. "Dysregulation of glycerophospholipid metabolism during Behçet's disease contributes to a pro-inflammatory phenotype of circulating monocytes.". Journal of translational autoimmunity (2020): https://europepmc.org/articles/PMC7388368.
    10.1016/j.jtauto.2020.100056
  16. "Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production.". Nature communications (2020): https://europepmc.org/articles/PMC7181847.
    10.1038/s41467-020-15832-6
  17. Mesquita, Inês; Ferreira, Carolina; Moreira, Diana; Kluck, George Eduardo Gabriel; Barbosa, Ana Margarida; Torrado, Egídio; Dinis-Oliveira, Ricardo Jorge; et al. "The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis". Cell Reports 30 12 (2020): 4052-4064.e7. http://dx.doi.org/10.1016/j.celrep.2020.02.098.
    10.1016/j.celrep.2020.02.098
  18. "Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization.". Frontiers in immunology (2020): https://europepmc.org/articles/PMC7876410.
    10.3389/fimmu.2020.589863
  19. Mariana Resende; Catarina M. Ferreira; Ana Margarida Barbosa; Marcos S. Cardoso; Jeremy Sousa; Margarida Saraiva; António G. Castro; Rui Appelberg; Egídio Torrado. "Myeloid HIF-1a regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection". Immunology 159 1 (2020): 121-129. https://doi.org/10.1111/imm.13131.
    10.1111/imm.13131
  20. Resende, M.; Cardoso, M.S.; Fróis-Martins, R.; Borges, M.; Jordan, M.B.; Castro, A.G.; Appelberg, R.. "TNF-mediated compensatory immunity to mycobacterium avium in the absence of macrophage activation by IFN-¿". Journal of Immunology 203 9 (2019): 2451-2458. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073667502&partnerID=MN8TOARS.
    10.4049/jimmunol.1801594
  21. Meira, L.; Chaves, C.; Araújo, D.; Almeida, L.; Boaventura, R.; Ramos, A.; Carvalho, T.; et al. "Predictors and outcomes of disseminated tuberculosis in an intermediate burden setting". Pulmonology 25 6 (2019): 320-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-85061974321&partnerID=MN8TOARS.
    10.1016/j.pulmoe.2018.11.001
  22. Fraga, A.G.; Trigo, G.; Murthy, R.K.; Akhtar, S.; Hebbur, M.; Pacheco, A.R.; Dominguez, J.; et al. "Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection". PLoS Neglected Tropical Diseases 13 8 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071832074&partnerID=MN8TOARS.
    10.1371/journal.pntd.0007113
  23. Castro, Gil. "The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis". Cytokine (2018): http://dx.doi.org/10.1016/j.cyto.2018.07.001.
    10.1016/j.cyto.2018.07.001
  24. Castro, Gil. "A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis". mSphere (2018): http://dx.doi.org/10.1128/msphere.00352-18.
    10.1128/msphere.00352-18
  25. Castro, Gil. "L-Threonine Supplementation During Colitis Onset Delays Disease Recovery". Frontiers in Physiology (2018): http://dx.doi.org/10.3389/fphys.2018.01247.
    10.3389/fphys.2018.01247
  26. Castro, Gil. "The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis". Frontiers in Immunology (2018): http://dx.doi.org/10.3389/fimmu.2018.00400.
    10.3389/fimmu.2018.00400
  27. Silva, E.M.; Mariano, V.S.; Aguiar Pastrez, P.R.; Pinto, M.C.; Castro, A.G.; Syrjanen, K.J.; Longatto-Filho, A.. "High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer". PLoS ONE 12 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85024483810&partnerID=MN8TOARS.
    10.1371/journal.pone.0181125
  28. Cunha, C.; Gonçalves, S.M.; Duarte-Oliveira, C.; Leite, L.; Lagrou, K.; Marques, A.; Lupiañez, C.B.; et al. "IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity". Journal of Allergy and Clinical Immunology 140 3 (2017): 867-870.e9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019152778&partnerID=MN8TOARS.
    10.1016/j.jaci.2017.02.034
  29. Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.. "Interferon-ß regulates the production of IL-10 by toll-like receptor-activated microglia". GLIA 65 9 (2017): 1439-1451. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021258982&partnerID=MN8TOARS.
    10.1002/glia.23172
  30. Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.. "Balancing the immune response in the brain: IL-10 and its regulation". Journal of Neuroinflammation 13 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997106994&partnerID=MN8TOARS.
    10.1186/s12974-016-0763-8
  31. Bastos, H.N.; Osório, N.S.; Castro, A.G.; Ramos, A.; Carvalho, T.; Meira, L.; Araújo, D.; et al. "A prediction rule to stratify mortality risk of patients with pulmonary tuberculosis". PLoS ONE 11 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84992386220&partnerID=MN8TOARS.
    10.1371/journal.pone.0162797
  32. Silva, J.P.; Gonçalves, C.; Costa, C.; Sousa, J.; Silva-Gomes, R.; Castro, A.G.; Pedrosa, J.; Appelberg, R.; Gama, F.M.. "Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment". Journal of Controlled Release 235 (2016): 112-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973165158&partnerID=MN8TOARS.
    10.1016/j.jconrel.2016.05.064
  33. Moreira-Teixeira, L.; Sousa, J.; McNab, F.W.; Torrado, E.; Cardoso, F.; Machado, H.; Castro, F.; et al. "Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-¿ signaling". Journal of Immunology 197 12 (2016): 4714-4726. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002328285&partnerID=MN8TOARS.
    10.4049/jimmunol.1600584
  34. Cruz, A.; Torrado, E.; Carmona, J.; Fraga, A.G.; Costa, P.; Rodrigues, F.; Appelberg, R.; et al. "BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells". Vaccine 33 1 (2015): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919360521&partnerID=MN8TOARS.
    10.1016/j.vaccine.2014.11.013
  35. Silva-Gomes, R.; Marcq, E.; Trigo, G.; Gonçalves, C.M.; Longatto-Filho, A.; Castro, A.G.; Pedrosa, J.; Fraga, A.G.. "Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model". PLoS Neglected Tropical Diseases 9 12 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84953274374&partnerID=MN8TOARS.
    10.1371/journal.pntd.0004265
  36. Cardoso, F.; Castro, F.; Moreira-Teixeira, L.; Sousa, J.; Torrado, E.; Silvestre, R.; Castro, A.G.; Saraiva, M.; Pais, T.F.. "Myeloid sirtuin 2 expression does not impact long-term Mycobacterium tuberculosis control". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940426429&partnerID=MN8TOARS.
    10.1371/journal.pone.0131904
  37. Cruz, A.; Ludovico, P.; Torrado, E.; Gama, J.B.; Sousa, J.; Gaifem, J.; Appelberg, R.; et al. "IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages". Frontiers in Immunology 6 SEP (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946550863&partnerID=MN8TOARS.
    10.3389/fimmu.2015.00498
  38. Carvalho, A.; Costa, P.; Triunfante, V.; Branca, F.; Rodrigues, F.; Santos, C.L.; Correia-Neves, M.; et al. "Analysis of a local HIV-1 epidemic in portugal highlights established transmission of Non-B and Non-G subtypes". Journal of Clinical Microbiology 53 5 (2015): 1506-1514. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928032043&partnerID=MN8TOARS.
    10.1128/JCM.03611-14
  39. Teixeira-Coelho, M.; Guedes, J.; Ferreirinha, P.; Howes, A.; Pedrosa, J.; Rodrigues, F.; Lai, W.S.; et al. "Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages". European Journal of Immunology 44 3 (2014): 856-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896030127&partnerID=MN8TOARS.
    10.1002/eji.201343734
  40. Santos, T.C.; Höring, B.; Reise, K.; Marques, A.P.; Silva, S.S.; Oliveira, J.M.; Mano, J.F.; et al. "In vivo performance of chitosan/soy-based membranes as wound-dressing devices for acute skin wounds". Tissue Engineering - Part A 19 7-8 (2013): 860-869. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874732614&partnerID=MN8TOARS.
    10.1089/ten.tea.2011.0651
  41. Menino, J.F.; Saraiva, M.; Gomes-Rezende, J.; Sturme, M.; Pedrosa, J.; Castro, A.G.; Ludovico, P.; Goldman, G.H.; Rodrigues, F.. "P. brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation". PLoS ONE 8 9 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884191896&partnerID=MN8TOARS.
    10.1371/journal.pone.0074725
  42. Carmona, J.; Cruz, A.; Moreira-Teixeira, L.; Sousa, C.; Sousa, J.; Osorio, N.S.; Saraiva, A.L.; et al. "Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response". PLoS ONE 8 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879468975&partnerID=MN8TOARS.
    10.1371/journal.pone.0067277
  43. Horta, A.; Nobrega, C.; Amorim-Machado, P.; Coutinho-Teixeira, V.; Barreira-Silva, P.; Boavida, S.; Costa, P.; et al. "Poor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4+ T Cells". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874234588&partnerID=MN8TOARS.
    10.1371/journal.pone.0057336
  44. Trigo, G.; Martins, T.G.; Fraga, A.G.; Longatto-Filho, A.; Castro, A.G.; Azeredo, J.; Pedrosa, J.. "Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model". PLoS Neglected Tropical Diseases 7 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876876365&partnerID=MN8TOARS.
    10.1371/journal.pntd.0002183
  45. Menino, J.F.; Saraiva, M.; Gomes-Alves, A.G.; Lobo-Silva, D.; Sturme, M.; Gomes-Rezende, J.; Saraiva, A.L.; et al. "TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival". PLoS Neglected Tropical Diseases 7 7 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880846173&partnerID=MN8TOARS.
    10.1371/journal.pntd.0002317
  46. Rada, T.; Carvalho, P.P.; Santos, T.C.; Castro, A.G.; Reis, R.L.; Gomes, M.E.. "Chondrogenic potential of two hASCs subpopulations loaded onto gellan gum hydrogel evaluated in a nude mice model". Current Stem Cell Research and Therapy 8 5 (2013): 357-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888089078&partnerID=MN8TOARS.
    10.2174/1574888X113089990049
  47. Osório, N.S.; Rodrigues, F.; Gagneux, S.; Pedrosa, J.; Pinto-Carbó, M.; Castro, A.G.; Young, D.; Comas, I.; Saraiva, M.. "Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure". Molecular Biology and Evolution 30 6 (2013): 1326-1336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727980&partnerID=MN8TOARS.
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  48. Santos, T.C.; Morton, T.J.; Moritz, M.; Pfeifer, S.; Reise, K.; Marques, A.P.; Castro, A.G.; Reis, R.L.; Van Griensven, M.. "Vascular endothelial growth factor and fibroblast growth factor-2 incorporation in starch-based bone tissue-engineered constructs promote the in vivo expression of neovascularization mediators". Tissue Engineering - Part A 19 7-8 (2013): 834-848. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874685019&partnerID=MN8TOARS.
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  49. Fraga, A.G.; Martins, T.G.; Torrado, E.; Huygen, K.; Portaels, F.; Silva, M.T.; Castro, A.G.; Pedrosa, J.. "Cellular immunity confers transient protection in experimental buruli ulcer following BCG or mycolactone-negative mycobacterium ulcerans vaccination". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857837898&partnerID=MN8TOARS.
    10.1371/journal.pone.0033406
  50. Mishra, A.K.; Alves, J.E.; Krumbach, K.; Nigou, J.; Castro, A.G.; Geurtsen, J.; Eggeling, L.; Saraiva, M.; Besra, G.S.. "Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation". Journal of Biological Chemistry 287 53 (2012): 44173-44183. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871782017&partnerID=MN8TOARS.
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Outros

Outra produção
  1. Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection. 2018. Fraga, A.G.; Trigo, G.; Dominguez, J.; Silva-Gomes, R.; Gonçalves, C.M.; Hugo, O.; Castro, A.G.; Azeredo, J.; Pedrosa, J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092863359&partnerID=MN8TOARS.
    10.1101/507129
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017 - Atual Epigenetics and Genetics of Hematopoietic Stem Cells Heterogeneity
Coorientador
Instituto Gulbenkian de Ciência, Portugal
2017 - Atual Production, characterization and functionalization of dendronized polymers as aAPC systems
Coorientador
Universidade do Minho - Campus de Azurém, Portugal
2017 - Atual Dissecting the immunometabolic crosstalk of IL-17A/F-induced macrophage reprogramming during infection
Coorientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012 - 2017 Assembly of granulomas during mycobacterial infections in mice: cellular and molecular dynamics
Orientador
Universidade do Minho Escola de Medicina, Portugal
2009 - 2016 Polyssacharide-based nanogels: novel tackling and treating approach of non-small cancer lung cells
Coorientador
Universidade do Minho Escola de Engenharia, Portugal
2013 - 2014 Impact of IL-10 and SIRT-2 in the protective immune response to Mycobacterium tuberculosis and Listeria monocytogenes infections
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2013 Paracoccidioides brasiliensis: virulence factors and host susceptibility
Coorientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2013 Characterization of the immune response following infection by multi-drug-resistant strains of Mycobacterium tuberculosis
Orientador
Universidade do Minho Escola de Medicina, Portugal
2007 - 2012 Impact of mycobacterial recognition by toll like receptors in the regulation of IL-10 and T helper type of responses
Orientador
Universidade do Minho Escola de Medicina, Portugal
2010 - 2011 Regulatory CD4+ T cells in the immune system homeostasis of HIV-infected patients under anti-retroviral therapy
Orientador
2010 - 2011 Importance of TLR2 on recognition and IL-17 presence on the innate immune responses to mycobacteria
Orientador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2010 Understanding Buruli Ulcer: Elucidation of the cellular and molecular mechanisms underlying infection with Mycobacterium ulcerans
Coorientador
Universidade do Minho Escola de Medicina, Portugal
2004 - 2009 In vivo performance and assessment of inflammatory response to starch-based scaffolds for tissue engineering
Coorientador
Universidade do Minho, Portugal
2003 - 2006 Understanding BCG vaccination: implications for the design of new preventive strategies against mycobacteriosis
Orientador
Universidade do Minho Escola de Medicina, Portugal
2004 - 2005 Prevenção das parasitoses gastrintestinais – de transmissão fecal-oral
Orientador
Universidade do Porto Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019 - 2019 Research Seminar “The frontiers of research in ILD (2019 - 2019)
Conferência (Membro da Comissão Organizadora)
2019 - 2019 XII Minho Medical Meeting (2019 - 2019)
Encontro (Membro da Comissão Científica)
 Universidade do Minho Escola de Medicina, Portugal
2015 - 2015 XLI Reunião Anual da Sociedade Portuguesa de Imunologia (SPI): “From basic Immunology to the latest clinical breakthrough (2015 - 2015)
Congresso (Membro da Comissão Organizadora)
 Universidade do Minho Escola de Medicina, Portugal
2010 - 2010 XXXVI Reunião Anual da Sociedade Portuguesa de Imunologia (SPI): “Fighting Intracellular Pathogens: from bench to bedside (2010 - 2010)
Congresso (Membro da Comissão Organizadora)
2006 - 2006 XXXII Reunião Anual da Sociedade Portuguesa de Imunologia (SPI): “Innate and Acquired Immunity: evolution and regulation” (2006 - 2006)
Congresso (Membro da Comissão Organizadora)
 Universidade do Minho Escola de Medicina, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2018/05/23 Sensing and transcriptional requirements of innate lymphoid cells
Arguente principal
 Rita Gomes Domingues (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 Mechanisms of action and antimycobacterial activity of antimicrobial peptides
Arguente principal
 Tânia Martins da Silva (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/12/17 Towards the therapeutic use of regulatory T cells for the treatment of human autoimmune diseases
Arguente principal
 Maria Catarina Mota da Silva (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/07/13 Immunoglobulin, somatic hypermutation and the survival of B cells
Arguente principal
 Pedro José Ponce de Leão de Azevedo Geraldes (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/06/29 Cationic liposomes as antigen delivery systems: developemnt of na immunoprotective strategy against Candida albicans
Arguente principal
 Maria Catarina Santos Carneiro (Doutoramento)
Universidade do Minho Departamento de Biologia, Portugal
2014 Macrophage-Mycobacterium avium subsp. paratuberculosis interplay in inflammatory bowel disease: possible immunopathological implications
Arguente principal
 Nair Alexandra Barbosa Nazareth Campos (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2013/11/21 Unravel key elements of tissue engineering constructs in the route to skin regeneration
Arguente principal
 MarianaTeixeira Cerqueira (Doutoramento)
Universidade do Minho Centro de Engenharia Biológica, Portugal
2013/10/16 The immune response to mycobacteria of distinct virulence
Arguente principal
 Manuel António Afonso Pereira Barroso (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/01/25 Impact of immunomodulatory proteins: at the level of the cell and the whole animal
Arguente principal
 Vivian Leite de Oliveira (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/03/16 The Leishmania TDR1 family-related gene: functional studies and evaluation of TDR1 recombinant protein as a vaccine against leishmaniasis
Arguente principal
 Ana Marta Franco da Silva (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2011 Co-cultures and cell sheet engineering as relevant tools to improve the outcome of bone tissue engineering strategies
Arguente
 Rogério Pedro Lemos de Sousa Pirraco (Doutoramento)
Universidade do Minho Escola de Engenharia, Portugal
2010 CD38 and Immune function: role of infections by intracellular bacteria and systemic autoimmunity
Arguente principal
 Marta Susana de Almeida Viegas da Silva (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010 On the origin of Human CD8+ NK-like T cells: a role for IL-15 and hepatocytes?
Arguente principal
 Margareta Isabel Pereira Correia (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009 Modulação de células dendriticas e monócitos pelo vírus da imunodeficiência Humana tipo 2
Arguente principal
 Rita Jorge Dias Cavaleiro (Doutoramento)
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
2008 The role of antigen presenting cells in immune regulation mediated by regulatory T cells
Arguente principal
 Andreia Cristina Leitão Correia Simão Lino (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006 GFP Tagged IL-10 Knock-in Mice
Arguente principal
 Dinis Pedro Parente Calado (Doutoramento)
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
2005 Inflammatory responses to biomaterials: interactions between leukocytes and self-assembled monolayers
Arguente principal
 Maria Judite Tavares Moreira Novais Barbosa (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2004 Clonagem e caracterização de proteínas imunomoduladoras de Streptococcus sobrinus
Arguente
 Isabel Vicência Franco Campos Matias da Veiga Malta (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2004 Regulatory CD4 T cell function and dynamics in inflammation
Arguente principal
 Íris Maria Ferreira Caramalho (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2001 Modulação da resposta imunológica do ratinho à infecção pelo Mycobacterium avium: papel da IL-10 e da IL-12 em estratégias de imunomodulação, vacinação e quimioterapia
Vogal
 Regina Augusta Alves Pereira da Silva (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2001 Cytokines as potential co-adjuvants in a subunit vaccine against tuberculosis
Arguente
 Irene Sofia Leal (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000 Protecção por neutrófilos nas infecções murinas por Mycobacterium tuberculosis e Mycobacterium avium: uma actividade não-fagocítica de um fagócito profissional
Arguente
 Jorge Pedrosa (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000 Interacção do Mycobacterium avium com o macrófago em apoptose
Vogal
 Teresa Faria Pais (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000 Interacção Mycobacterium avium – hospedeiro: factores de virulência e mecanismos de resistência
Vogal
 Manuela Florido (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2011 - Atual Frontiers in Immunology (1664-3224) Frontiers Media SA

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2019 - Atual Membro de painel de avaliação do Concurso de Bolsas de Doutoramento
Avaliador
 Associação para a Inovação e Desenvolvimento da FCT, Portugal Associação para a Inovação e Desenvolvimento da FCT

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2019 - 2019 Graduate woman in science

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2011 Prémio Pulido Valente Ciência atribuído a estudo da UMinho UMDicas
2011 Revacinação com BCG pode ter "efeito maléfico" Jornal Noticias

Entrevista / Programa (rádio / tv)

Programa Tema
2011 - 2011 SIC Noticias Investigação: Estudo da Universidade do Minho recebe Prémio Pulido Valente Ciência 2010
2011 - 2011 RTP Noticias Revacinação com BCG pode ser negativa

Membro de associação

Nome da associação Tipo de participação
1998 - Atual Sociedade Portuguesa de Imunologia Sócio e Presidente Conselho Fiscal
Distinções

Prémio

2010 SPI Best Paper Award
Sociedade Portuguesa de Imunologia, Portugal
2010 Prémio Pulido Valente Ciência
2006 Prémio de Excelência em Imunologia Mário Arala Chaves
Sociedade Portuguesa de Imunologia, Portugal
1994 Prémio Pfizer
Pfizer Portugal, Portugal