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I completed in 2012 a PhD in Biosciences (Cell and Molecular Biology) at the University of Coimbra, working in the ‘Mitochondria, Metabolism & Disease’ group at CNC under the supervision of Prof. Carlos Palmeira (Department of Life Sciences, University of Coimbra), an expert on mitochondria. During the PhD, I visited the lab of Prof. Luca Scorrano (University of Padua, Italy) where I learned cutting-edge approaches for the study of mitochondrial biology and mitochondrial dynamics (fusion/fission). I was hired in 2013 as an Invited Assistant Professor at the University of Coimbra, teaching Cell and Molecular Biology. In 2014 I got a Postdoc fellowship in a competitive call from FCT for studying the role of miRNAs in mitochondria, namely in metabolic disease. Also, I continued working on several projects enduring in the lab: mitochondrial regulation and bioenergetics stimulation as a therapeutic strategy in hyperglycemia, obesity, metabolic syndrome and diabetes; improving mitochondria in Parkinson’s Disease (funded by MJFox Foundation); mitophagy and mitochondrial biogenesis following exposure to environmental toxicants (funded by CAPES, Brazil) or to silver nanoparticles (funded by US Aerospace R&D); mitochondrial biogenesis and beneficial effects of berberine and resveratrol/SIRT1 activation in metabolic dysfunction. In 2016, I joined Exogenus Therapeutics (Biocant Park, Cantanhede, Portugal), as an R&D scientist; this is a drug development company using exosome-based technology to develop innovative therapeutic agents. In 2018, I joined the Neuronal Signaling research group at CNC, led by Prof. Carlos Duarte (Department of Life Sciences, University of Coimbra). I worked on an exciting project about the role of neuronal chloride homeostasis in epilepsy (PI: Dr. Miranda Mele). From 2019 I have been invited to teach Methods in Molecular Biology at the University of Coimbra; this not only forces me to keep molecular biology concepts and methods updated but also gets me to know students who are promising scientists allowing me to train them with more enthusiasm. From 2021 I have been working on a funded project entitled ‘Regulation of mitochondrial fission by brain-derived neurotrophic factor (BDNF): role in synaptic plasticity and in epileptogenesis’, in which I am co-PI. In the last years, additionally to working directly on the research project designing and performing experiments, I have also been much involved in training/supervising several students in the laboratory. From 2023 I am an Invited Assistant Professor at the Department of Life Sciences of the University of Coimbra, where I have been teaching biochemistry, molecular biology and neurobiology-related courses for undergrad and MSc degrees. Published a total of 34 journal articles in international peer-reviewed journals (including seven as 1st author and two as last author) and 3 book chapters (one as 1st author), reaching an H-index of 20 with 10 000+ total citations (Scopus and Web of Science). Among these are 2 highly cited papers (top 1% in the academic field). Co-PI in a project on mitochondria, BDNF and epilepsy, entitled 'Regulation of mitochondrial fission by brain-derived neurotrophic factor (BDNF): role in synaptic plasticity and in epileptogenesis'.
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Identificação

Identificação pessoal

Nome completo
Filipe Valente Duarte
Género
Masculino

Nomes de citação

  • Duarte, FV

Identificadores de autor

Ciência ID
2F19-B13F-C24C
ORCID iD
0000-0003-0287-0328
Researcher Id
M-7714-2013
Scopus Author Id
35933126100

Endereços de correio eletrónico

  • fvduarte@uc.pt (Profissional)

Telefones

Fax
  • 239822776 (Profissional)
Telefone
  • 239820190 (Profissional)

Moradas

  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas
  • Ciências Médicas e da Saúde - Medicina Básica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Italiano Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A1) Utilizador independente (B2)
Formação
Grau Classificação
2015/07
Concluído
 Biosatistics for research (Postgraduate Certificate)
Laboratory of Biostatistics and Medical Informatics (LBIM) - Coimbra Institute for Clinical and Biomedical Research (ICBR), Portugal
2014/12
Concluído
 2nd Course in Mitochondrial Medicine (Postgraduate Certificate)
MEET - Mitochondrial European Educational Training, Itália
2012/11/30
Concluído
 PhD in Biosciences (Doctor)
Especialização em Specialization in Cell and Molecular Biology
Faculty of Sciences and Technology, University of Coimbra, Portugal
"Dibenzofuran exposure: cellular and mitochondrial damage." (TESE/DISSERTAÇÃO)
 Approved with distinction and honors (grade 20/20)
2010
Concluído
 Proteomics Workshop (Postgraduate Certificate)
Mass Spectrometry Center, University of Aveiro, Portugal
"n/a" (TESE/DISSERTAÇÃO)
2009/01
Concluído
 Inflammation: an experimental approach (Postgraduate Certificate)
Centre of Molecular Pathogenesis, Faculty of Pharmacy, University of Lisbon, Portugal
"n/a" (TESE/DISSERTAÇÃO)
2009
Concluído
 Gene silencing using RNA interference (Postgraduate Certificate)
Life and Health Sciences Research Institute (ICVS), School of Health Sciences (ECS), University of Minho, Portugal
"Gene silencing using RNA interference" (TESE/DISSERTAÇÃO)
2007/07/31
Concluído
 Degree in Biology (BSc) (Bachelor)
Especialização em Scientific Specialization
Faculty of Sciences and Technology, University of Coimbra, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 Good (16/20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/09 - 2024/08 Investigador Contratado (Investigação) CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2016/06/01 - 2018/08/31 Investigador Contratado (Investigação) Exogenus Therapeutics, Portugal
2014/09 - 2016/05 Pós-doutorado (Investigação) CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/09 - Atual Professor Auxiliar Convidado (Docente Universitário) Department of Life Sciences, University of Coimbra, Portugal
2013/09/01 - 2014/08/31 Professor Auxiliar Convidado (Docente Universitário) Department of Life Sciences, University of Coimbra, Portugal
Projetos

Bolsa

Designação Financiadores
2014/09 - 2016/05 The role of miRNAs in the mitochondrial regulation in metabolic disease
SFRH/BPD/94898/2013
Bolseiro de Pós-Doutoramento
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Desativado
2013/09 - 2016/05 Evaluation of the ability of PBDEs exposure to induce autophagy/mitophagy and cause mitochondrial biogenesis alterations in HepG2 cells
A018_2013
Bolseiro de Cientista Convidado
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 National Research Center (CNPq - Brazil)
Concluído
2010/03 - 2013/03 Long-term beneficial influence of early metabolic control: prevention of hyperglycemic memory through stimulation of bioenergetics
Provided by PTCRIS: 103514
PTDC / QUI-BIQ / 103514 / 2008
103514
Bolseiro de Integração na Investigação
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/12 - 2012/12 Ability of a mitochondria improver, Berberine, to attenuate Parkinson's Disease
RRIA 2011
Bolseiro de Integração na Investigação
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 The Michael J. Fox foundation for Parkinson’s Research
Concluído
2007/09 - 2012/11 Dibenzofuran exposure: cellular and mitochondrial damage
n/a
Bolseiro de Doutoramento
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/09 - 2010/08 Alterations in the physiological pathways and molecular mechanisms regulating energy homeostasis in obesity and metabolic syndrome - Identification of new strategies and therapeutical targets
PTDC / SAU-OSM / 72443 / 2006
Bolseiro de Integração na Investigação
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2008/01 - 2010/01 Modulation of the metabolic pathways regarding mitochondrial oxidative stress in hyperglycemic conditions - Relevance for diabetes prevention
PTDC / QUI / 72826 / 2006
Bolseiro de Integração na Investigação
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2021/03 - Atual Regulation of mitochondrial fission by brain-derived neurotrophic factor (BDNF): role in synaptic plasticity and in epileptogenesis (co-PI)
PTDC / MED-NEU / 3736 / 2020
Investigador responsável
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
2018/10 - 2021/05 Targeting the K+-Cl- cotransporter (KCC2) to maintain GABAergic neurotransmission: a novel therapeutic strategy for epilepsy
PTDC / MED-FAR / 30659 / 2017
Investigador
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2013 - 2013 Chronic effects of silver nanoparticles (AgNPs) on rat liver, kidney and heart mitochondrial function
EOARD, ref. FA8655-13-1-3036
Bolseiro de Integração na Investigação
Department of Life Sciences, University of Coimbra, Portugal
 European Office of Aerospace Research and Development (USA)
Concluído
2007/06 - 2008/06 In vitro assessment of silver nanoparticles toxicity in hepatic mitochondrial function
EOARD, ref. FA8655- 07-1-3047
Bolseiro de Integração na Investigação
Department of Life Sciences, University of Coimbra, Portugal
 European Office of Aerospace Research and Development (USA)
Concluído
Produções

Publicações

Artigo em revista
  1. Marta Zaninello; Pedro Baptista; Filipe V. Duarte. "Mitochondrial Dynamics and mRNA Translation: A Local Synaptic Tale". Biology (2024): https://doi.org/10.3390/biology13090746.
    10.3390/biology13090746
  2. Filipe V. Duarte; Daniele Ciampi; Carlos B. Duarte. "Mitochondria as central hubs in synaptic modulation". Cellular and Molecular Life Sciences (2023): https://doi.org/10.1007/s00018-023-04814-8.
    10.1007/s00018-023-04814-8
  3. Inês C. Rodrigues; Sílvia C. Rodrigues; Filipe V. Duarte; Paula M. da Costa; Paulo M. da Costa. "The Role of Outer Membrane Proteins in UPEC Antimicrobial Resistance: A Systematic Review". Membranes (2022): https://doi.org/10.3390/membranes12100981.
    10.3390/membranes12100981
  4. Sílvia C. Rodrigues; Renato M. S. Cardoso; Patricia C. Freire; Cláudia F. Gomes; Filipe V. Duarte; Ricardo Pires das Neves; Joana Simões-Correia. "Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22189797.
    10.3390/ijms22189797
  5. Silvia C. Rodrigues; Renato M. S. Cardoso; Claudia F. Gomes; Filipe V. Duarte; Patricia C. Freire; Ricardo Neves; Joana Simoes-Correia. "Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles". Membranes (2021): https://doi.org/10.3390/membranes11090647.
    10.3390/membranes11090647
  6. Mele, Miranda; Vieira, Ricardo; Correia, Bárbara; De Luca, Pasqualino; Duarte, Filipe V.; Pinheiro, Paulo S.; Duarte, Carlos B.. "Transient incubation of cultured hippocampal neurons in the absence of magnesium induces rhythmic and synchronized epileptiform-like activity". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-90486-y.
    10.1038/s41598-021-90486-y
  7. Cardoso, Renato M. S.; Rodrigues, Silvia C.; Gomes, Claudia F.; Duarte, Filipe V.; Romao, Maryse; Leal, Ermelindo C.; Freire, Patricia C.; Neves, Ricardo; Simões-Correia, Joana. "Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use". Stem Cells Translational Medicine 10 6 (2021): 910-921. http://dx.doi.org/10.1002/sctm.20-0376.
    Publicado • 10.1002/sctm.20-0376
  8. Rodrigues, Sílvia C.; Cardoso, Renato M. S.; Duarte, Filipe V.. "Mitochondrial microRNAs: A Putative Role in Tissue Regeneration". Biology 9 12 (2020): 486. http://dx.doi.org/10.3390/biology9120486.
    Publicado • 10.3390/biology9120486
  9. Duarte, FV. "Mitochondrial physiology". Bioenergetics Communications (2020): http://dx.doi.org/10.26124/bec:2020-0001.v1.
    10.26124bec2020-0001.v1
  10. Marta Carmo; Francisco Q. Gonçalves; Paula M. Canas; Jean-Pierre Oses; Francisco D. Fernandes; Filipe V. Duarte; Carlos M. Palmeira; et al. "Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A 2A receptor over-activation in a rat model of Parkinson's disease". British Journal of Pharmacology (2019): https://doi.org/10.1111/bph.14771.
    10.1111/bph.14771
  11. Théry, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Alcaraz, Maria Jose; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; et al. "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines". Journal of Extracellular Vesicles 7 1 (2018): 1535750. http://dx.doi.org/10.1080/20013078.2018.1535750.
    10.1080/20013078.2018.1535750
  12. Lilian Cristina Pereira; Luiz Felipe Cabral Miranda; Mariana Furio Franco-Bernardes; Maria Julia Tasso; Filipe Valente Duarte; Ana Teresa Inácio Varela; Anabela Pinto Rolo; Carlos Manuel Marques Palmeira; Daniel Junqueira Dorta. "Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity". Chemico-Biological Interactions 291 (2018): 192-201. https://doi.org/10.1016/j.cbi.2018.06.021.
    10.1016/j.cbi.2018.06.021
  13. Teodoro JS; Varela AT; Duarte FV; Gomes AP; Palmeira CM; Rolo AP. "Indirubin and NAD+ prevent mitochondrial ischaemia/reperfusion damage in fatty livers.". European journal of clinical investigation (2018): http://europepmc.org/abstract/med/29603199.
    10.1111/eci.12932
  14. Pereira LC; Duarte FV; Varela ATIF; Rolo AP; Palmeira CMM; Dorta DJ. "Exposure to BDE-153 induces autophagy in HepG2 cells.". Toxicology in vitro : an international journal published in association with BIBRA (2017): http://europepmc.org/abstract/med/28396260.
    10.1016/j.tiv.2017.04.005
  15. Duarte FV; Amorim JA; Varela AT; Teodoro JS; Gomes AP; Cunha RA; Palmeira CM; Rolo AP. "Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver.". Purinergic signalling (2017): http://europepmc.org/abstract/med/27848069.
    10.1007/s11302-016-9548-x
  16. Lilian Cristina Pereira; Filipe Valente Duarte; Ana Teresa Inácio Ferreira Varela; Anabela Pinto Rolo; Carlos Manuel Marques Palmeira; Daniel Junqueira Dorta. "An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity". Toxicology 376 (2017): 59-65. https://doi.org/10.1016/j.tox.2016.05.022.
    10.1016/j.tox.2016.05.022
  17. Pereira, L.C.; Souza, A.O.; Tasso, M.J.; Oliveira, A.M.C.; Duarte, F.V.; Palmeira, C.M.; Dorta, D.J.. "Exposure to decabromodiphenyl ether (BDE-209) produces mitochondrial dysfunction in rat liver and cell death". Journal of Toxicology and Environmental Health - Part A: Current Issues 80 19-21 (2017): 1129-1144. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033371791&partnerID=MN8TOARS.
    10.1080/15287394.2017.1357370
  18. Souza AO; Tasso MJ; Oliveira AM; Pereira LC; Duarte FV; Oliveira DP; Palmeira CM; Dorta DJ. "Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47).". Basic & clinical pharmacology & toxicology (2016): http://europepmc.org/abstract/med/27060917.
    10.1111/bcpt.12598
  19. Teodoro JS; Gomes AP; Varela AT; Duarte FV; Rolo AP; Palmeira CM. "Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats.". Toxicology mechanisms and methods (2016): http://europepmc.org/abstract/med/27790925.
    10.1080/15376516.2016.1222643
  20. Teodoro JS; Silva R; Varela AT; Duarte FV; Rolo AP; Hussain S; Palmeira CM. "Low-dose, subchronic exposure to silver nanoparticles causes mitochondrial alterations in Sprague-Dawley rats.". Nanomedicine (London, England) (2016): http://europepmc.org/abstract/med/27171910.
    10.2217/nnm-2016-0049
  21. Duarte, F.V.; Amorim, J.A.; Palmeira, C.M.; Rolo, A.P.. "Regulation of Mitochondrial Function and its Impact in Metabolic Stress". Current Medicinal Chemistry 22 20 (2015): 2468-2479. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938567587&partnerID=MN8TOARS.
    10.2174/0929867322666150514095910
  22. Duarte, F.V.; Palmeira, C.M.; Rolo, A.P.. "The role of microRNAs in mitochondria: Small players acting wide". Genes 5 4 (2014): 865-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907528499&partnerID=MN8TOARS.
    10.3390/genes5040865
  23. Teodoro, J.S.; Zouhar, P.; Flachs, P.; Bardova, K.; Janovska, P.; Gomes, A.P.; Duarte, F.V.; et al. "Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice". International Journal of Obesity 38 8 (2014): 1027-1034. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905663740&partnerID=MN8TOARS.
    10.1038/ijo.2013.230
  24. Teodoro, J.S.; Gomes, A.P.; Varela, A.T.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M.. "Uncovering the beginning of diabetes: The cellular redox status and oxidative stress as starting players in hyperglycemic damage". Molecular and Cellular Biochemistry 376 1-2 (2013): 103-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874278002&partnerID=MN8TOARS.
    10.1007/s11010-012-1555-9
  25. Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Varela, A.T.; Peixoto, F.M.; Rolo, A.P.; Palmeira, C.M.. "Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation". Mitochondrion 13 6 (2013): 637-646. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884937949&partnerID=MN8TOARS.
    10.1016/j.mito.2013.09.002
  26. Duarte, F.V.; Gomes, A.P.; Teodoro, J.S.; Varela, A.T.; Moreno, A.J.M.; Rolo, A.P.; Palmeira, C.M.. "Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier". Toxicology in Vitro 27 8 (2013): 2160-2168. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885795993&partnerID=MN8TOARS.
    10.1016/j.tiv.2013.08.009
  27. Gomes, A.P.; Duarte, F.V.; Nunes, P.; Hubbard, B.P.; Teodoro, J.S.; Varela, A.T.; Jones, J.G.; et al. "Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis". Biochimica et Biophysica Acta - Molecular Basis of Disease 1822 2 (2012): 185-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-83255163155&partnerID=MN8TOARS.
    10.1016/j.bbadis.2011.10.008
  28. Duarte, F.V.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M.. "Exposure to dibenzofuran triggers autophagy in lung cells". Toxicology Letters 209 1 (2012): 35-42. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300268700005&KeyUID=WOS:000300268700005.
    10.1016/j.toxlet.2011.11.029
  29. Price, N.L.; Gomes, A.P.; Ling, A.J.Y.; Duarte, F.V.; Martin-Montalvo, A.; North, B.J.; Agarwal, B.; et al. "SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function". Cell Metabolism 15 5 (2012): 675-690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860477354&partnerID=MN8TOARS.
    10.1016/j.cmet.2012.04.003
  30. Duarte, F.V.; Simões, A.M.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M.. "Exposure to dibenzofuran affects lung mitochondrial function in vitro". Toxicology Mechanisms and Methods 21 8 (2011): 571-576. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000295177300002&KeyUID=WOS:000295177300002.
    10.3109/15376516.2011.576714
  31. Teodoro, J.S.; Simões, A.M.; Duarte, F.V.; Rolo, A.P.; Murdoch, R.C.; Hussain, S.M.; Palmeira, C.M.. "Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective". Toxicology in Vitro 25 3 (2011): 664-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952039156&partnerID=MN8TOARS.
    10.1016/j.tiv.2011.01.004
  32. Simes, A.M.; Duarte, F.V.; Teodoro, J.S.; Rolo, A.P.; Palmeira, C.M.. "Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and tetraethyl lead affects lung mitochondria bioenergetics". Toxicology Mechanisms and Methods 20 1 (2010): 1-6. http://www.scopus.com/inward/record.url?eid=2-s2.0-77149123078&partnerID=MN8TOARS.
    10.3109/15376510903527916
  33. Varela, A.T.; Simões, A.M.; Teodoro, J.S.; Duarte, F.V.; Gomes, A.P.; Palmeira, C.M.; Rolo, A.P.. "Indirubin-3'-oxime prevents hepatic I/R damage by inhibiting GSK-3ß and mitochondrial permeability transition". Mitochondrion 10 5 (2010): 456-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955424602&partnerID=MN8TOARS.
    10.1016/j.mito.2010.04.006
  34. Teodoro, J.S.; Rolo, A.P.; Duarte, F.V.; Simões, A.M.; Palmeira, C.M.. "Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression". Mitochondrion 8 5-6 (2008): 367-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949089576&partnerID=MN8TOARS.
    10.1016/j.mito.2008.07.008
  35. Varela, A.T.; Gomes, A.P.; Simões, A.M.; Teodoro, J.S.; Duarte, F.V.; Rolo, A.P.; Palmeira, C.M.. "Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction". Toxicology and Applied Pharmacology 233 2 (2008): 179-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-56049123388&partnerID=MN8TOARS.
    10.1016/j.taap.2008.08.005
Capítulo de livro
  1. Teodoro, João S.; Duarte, Filipe V.; Rolo, Anabela P.; Palmeira, Carlos M.. "Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals". In Nutraceuticals - Efficacy, Safety and Toxicity, editado por Ramesh C. Gupta, 387-400. Elsevier, 2016.
    10.1016/b978-0-12-802147-7.00028-0
  2. Duarte, Filipe V.; Palmeira, Carlos M.; Rolo, Anabela P.. "The Emerging Role of MitomiRs in the Pathophysiology of Human Disease". In Advances in Experimental Medicine and Biology, editado por G. Santulli, 123-154. Springer International Publishing, 2015.
    Publicado • 10.1007/978-3-319-22671-2_8
  3. Palmeira, Carlos M.; Duarte, Filipe V.; Teodoro, João S.; Varela, Ana T.; Rolo, Anabela P.; Duarte, FV. "Biomarkers of mitochondrial dysfunction and toxicity". In Biomarkers in Toxicology, 847-861. Elsevier, 2014.
    10.1016/b978-0-12-404630-6.00051-8
Edição de número de revista
  1. Duarte, FV; Cláudia M. Deus. "The Emerging Role of Mitochondria in Neurobiology". Biology (2024): mdpi.com/journal/biology/special_issues/VNGR57Y8P9.
    Editor convidado
  2. Duarte, FV. "Membranes: Opening the Door to Therapy". Membranes (2023): https://www.mdpi.com/journal/membranes/special_issues/357U3SEMY7.
    Editor convidado
  3. Duarte, FV. "New Advances in Epilepsy, Neurotransmission and Synaptic Function". Biology (2021): https://www.mdpi.com/journal/biology/special_issues/NAENSF.
    Editor convidado
Poster em conferência
  1. Duarte, FV. "K+-Cl--cotransporter (KCC2) as a novel therapeutic target for epilepsy". Trabalho apresentado em FIRST VIRTUAL ESN CONFERENCE: Future perspectives for European neurochemistry - a young scientists conference, 2021.
  2. Duarte, FV. "K+-Cl--cotransporter (KCC2) as a novel therapeutic strategy for epilepsy". Trabalho apresentado em 33º eENE (National Epilepsy Meeting, Portugal), 2021.
  3. Duarte, FV. "20+ conference posters (Full list available upon request)". Trabalho apresentado em International scientific conferences, 2020.
Pré-impressão
  1. Marta Zaninello; Pedro Baptista; Filipe V Duarte. "mRNA Trafficking and Local Translation: Shaping Mitochondria in the Synapse". 2024. https://doi.org/10.20944/preprints202408.1029.v1.
    10.20944/preprints202408.1029.v1
  2. R.M.S. Cardoso; S.C. Rodrigues; C. F. Gomes; F.V. Duarte; M. Romao; E.C. Leal; P.C. Freire; R. Neves; J. Simões-Correia. "Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use". 2020. https://doi.org/10.1101/2020.12.18.423416.
    10.1101/2020.12.18.423416
Resumo em conferência
  1. Duarte, FV. "15+ conference abstracts (Full list available upon request)". Trabalho apresentado em International scientific conferences, 2020.
Tese / Dissertação
  1. Palmeira, Carlos Manuel Marques; Rolo, Anabela Pinto. "Dibenzofuran exposure: cellular and mitochondrial damage". Doutoramento, 2012. http://hdl.handle.net/10316/21299.

Outros

Outra produção
  1. Mitochondrial respiratory states and rates. 2019. Duarte, FV.
    10.26124/mitofit:190001.v6
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/11/25 BDNF-induced synaptic plasticity: the role of mitochondrial fission International Conference on Cell Science and Regenerative Medicine
United Research Forum (Porto, Portugal)
2010/10 Dibenzofuran-induced mitochondrial dysfunction MITOFOOD - Bioactive Food Components, Mitochondrial Function and Health (COST Action FA0602)
Department of Life Sciences, University of Coimbra (Coimbra, Portugal)
2008/02 Obesity-related alterations in mitochondrial biogenesis and function: implications for metabolic disease Young Scientist Seminar
CNC - Center for Neuroscience and Cell Biology, University of Coimbra (Coimbra, Portugal)
2007/12 Exposure to Dibenzofuran affects lung mitochondria bioenergetics and cell proliferation XXXVIII Annual Meeting from the Portuguese Society of Pharmacology and VII Meeting of Toxicology
Portuguese Society of Pharmacology (Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023 - 2023 Regulation of mitochondrial fission by Brain-Derived Neurotrophic Factor (BDNF): role in synaptic plasticity
Coorientador
 Biotechnology (Licenciatura/Bacharelato)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2022 - 2022 Study of BDNF as mediator of mitochondrial fission in cultured hippocampal neurons.
Coorientador
 Biomedical Sciences (Licenciatura/Bacharelato)
Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya (Spain), Espanha
2020/02 - 2020/08 BDNF signaling in the regulation of neuronal mitochondria
Orientador de Chiara Corrado
 Biology (Mestrado)
Universita degli Studi di Salerno, Itália
2016 - 2017/12 Implementation of biomolecular methods to explore the mode of action of Exo-Wound in vitro
Coorientador de Cláudia Filipa de Oliveira Gomes
 Biochemistry (Specialization in biomolecular methods) (Mestrado)
University of Aveiro, Portugal
2013 - 2015 Modulation of mitochondrial stress response by sestrin 2
Coorientador de Maria Carolina Costa e Santos Baptista Rodrigues
 Applied Biology (Mestrado)
Department of Biology, University of Aveiro, Portugal
2013 - 2014 Modulation of mitochondrial function in obesity
Coorientador de Rute Arriegas
 Biochemistry (Licenciatura/Bacharelato)
University of Évora, Portugal
2012 - 2013 Does Alzheimer's disease selectively affect synaptic mitochondria?
Coorientador de João Filipe Alves Amorim
 Cell and Molecular Biology (Mestrado)
Department of Life Sciences, University of Coimbra, Portugal
2010 - 2011 Hyperglycemic memory in C2C12 cells: a mitochondrial view
Coorientador de Davide Zampieri
 Industrial Biotechnology (Mestrado)
University of Padova, Itália
2009 - 2010 The effects of Berberine in AMPK signaling and stimulation of mitochondrial function in diet-induced obesity model
Coorientador de Anabela Marques Simões
 Cell and Molecular Biology (Mestrado)
Department of Life Sciences, University of Coimbra, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2024 - Atual Symposium chair at the 25th ESN Biennial Meeting (May 2025, Naxos, Greece) Symposium title: RNA dynamics and translation - key to brain function (2024)
Simpósio (Outra)
 European Society for Neurochemistry, Reino Unido

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2008 - Atual Scientifiic dissemination activities - Ciência Viva initiative Ciência Viva initiative
2008 - Atual Scientific dissemination activities - European Researchers' Night
2024/06/25 - 2024/06/29 Poster presentation (BDNF-induced synaptic plasticity: the role of mitochondrial fission)
Congresso
 FENS Forum 2024
Federation of European Neuroscience Societies, Bélgica
2023/08/08 - 2023/08/11 Poster presentation (The interplay between BDNF signaling and hippocampal dendritic mitochondria)
Encontro
 ISN-ESN Meeting
International Society for Neurochemistry, Suiça

European Society for Neurochemistry, Reino Unido
2022/10/20 - 2022/10/21 Poster presentation (Regulation of hippocampal dendritic mitochondria by BDNF)
Encontro
 8th European Synapse Meeting
2021/12/01 - 2021/12/03 XVII Meeting of the Portuguese Society for Neurosciences (SPN)
Encontro
 XVII Meeting of the Portuguese Society for Neurosciences (SPN)
Portuguese Society for Neurosciences (SPN), Portugal
2020/01/23 - 2020/01/24 The Neurobiology of Socio-Sexual Behavior - Mini-symposium
Simpósio
 The Neurobiology of Socio-Sexual Behavior - Mini-symposium
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2019/05/30 - 2019/06/01 XVI Meeting of the Portuguese Society for Neurosciences (SPN)
Encontro
 XVI Meeting of the Portuguese Society for Neurosciences (SPN)
Portuguese Society for Neurosciences (SPN), Portugal
2018/02/16 - 2018/02/17 1st Meeting on Vesicular Biology
Encontro
 1st Meeting on Vesicular Biology
Faculty of Medicine, University of Coimbra, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021 - Atual Biology (Topical Advisory Panel)
2020 - 2021 Biology (Topic Editor Board) MDPI
2019 - 2021 MitoFit Preprints (International Editorial Board)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024/09 - Atual 2024 Summer School in Computational Biology Universidade de Coimbra, Portugal
2019 - Atual MTBM - Métodos e Técnicas em Biologia Molecular (Methods and Techniques in Molecular Biology) Biology (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2013 - 2016 Obesity-related alterations in mitochondrial biogenesis and function - Implications for metabolic disease Course: Eating Disorders and Metabolic Diseases. Master’s degree in Cellular and Molecular Biology, University of Coimbra (Postgraduate Certificate) Department of Life Sciences, University of Coimbra, Portugal
2008 - 2016 Dioxins and lung toxicity Course: Toxicity and Disease. Master’s degree in Cellular and Molecular Biology, University of Coimbra (Postgraduate Certificate) Department of Life Sciences, University of Coimbra, Portugal
2008 - 2016 Mitochondrial dynamics and disease Course: Toxicity and Disease. Master’s degree in Cellular and Molecular Biology, University of Coimbra (Postgraduate Certificate) Department of Life Sciences, University of Coimbra, Portugal
2008 - 2016 Environmental pollution and respiratory diseases Course: Toxicity and Disease. Master’s degree in Cellular and Molecular Biology, University of Coimbra (Postgraduate Certificate) Department of Life Sciences, University of Coimbra, Portugal
2013/05 - 2013/05 Mitochondrial morphology and dynamics Advanced Course in “Cellular Mechanisms of Disease” (Postgraduate Certificate) Department of Biology, University of Aveiro, Portugal
2013/05 - 2013/05 Metabolism regulation: The role of genetic mechanisms Advanced Course in “Cellular Mechanisms of Disease” (Postgraduate Certificate) Department of Biology, University of Aveiro, Portugal
2013/02 - 2013/02 (Epi)Genetic regulation of mitochondrial function and metabolism diseases Advanced Course in “Interactions of Nutrients with Mitochondria and Gene Expression”. Doctoral Programme in Experimental Biology and Biomedicine (BEB) (Postgraduate Certificate) CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
2013/01 - 2013/01 Mitochondrial morphology and dynamics Advanced Course in “Molecular and Cellular Toxicology” (Postgraduate Certificate) Department of Biology, University of Aveiro, Portugal
2013/01 - 2013/01 Environmental pollutants: toxicity and disease Advanced Course in “Molecular and Cellular Toxicology” (Postgraduate Certificate) Department of Biology, University of Aveiro, Portugal
2012/02 - 2012/02 Environmental pollutants: toxicity and disease Advanced Course in “Molecular Biology and Genetics: Toxicity, Metabolism and Disease” (Postgraduate Certificate) Department of Biology, University of Aveiro, Portugal
2012/02 - 2012/02 Mitochondrial morphology and dynamics: rescue from dysfunction? Advanced Course in “Molecular Biology and Genetics: Toxicity, Metabolism and Disease” (Postgraduate Certificate) Department of Biology, University of Aveiro, Portugal
2008 - 2012 Environmental pollutants as endocrine disruptors Course: Endocrine Disruptors. Master’s degree in Cellular and Molecular Biology, University of Coimbra (Postgraduate Certificate) Department of Life Sciences, University of Coimbra, Portugal
2011/02 - 2011/02 Rescue from dysfunction: mitochondria and salvage strategies. Advanced Course in “Mitochondrial Dynamics and Metabolic Diseases”. Doctoral Programme in Experimental Biology and Biomedicine (BEB) (Postgraduate Certificate) CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Portugal

Membro de associação

Nome da associação Tipo de participação
2023 - Atual European Society for Neurochemistry (ESN)
2023 - Atual International Society for Neurochemistry (ISN)
2023 - Atual Federation of European Neuroscience Societies (FENS)
2019 - 2021 Portuguese Society for Neurosciences (SPN) Member
2016 - 2018 International Society for Extracellular Vesicles (ISEV) Member
2007 - 2016 Portuguese Biochemical Society (SPB) Member

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2018 - Atual Several journals, listed below
Distinções

Prémio

2013 Postdoc fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2007 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2022 Fellowship to attend the the 8th European Synapse Meeting
2014 Fellowship to attend the MEET '2nd Course in Mitochondrial Medicine'
MEET - Mitochondrial European Educational Training, Itália
2013 Fellowship to attend the 38th FEBS Congress - Mechanisms in Biology