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Researcher at the Center for Neuroscience and Cell Biology, University of Coimbra, and Assistant Professor at the Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal. Obtained his PhD degree in Biochemistry in 2007, MSc degree Cell Biology in 1996, and Bachelor degree in Biochemistry in 1990, all of them by the Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal. Has co-authored 60 research papers, all of them published in peer-reviewed scientific international journals (h-index = 25; >2360 citations; WoS, February 2024). Co-supervised 1 PhD project, and co-supervised more than 60 MSc projects. Field of expertise is Neurosciences. Keywords: neuromodulation, neuroprotection, adenosine, caffeine, ATP, A2A adenosine receptors, hippocampus, synaptic plasticity, memory, Alzheimer's disease.
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Identificação

Identificação pessoal

Nome completo
Ângelo José Ribeiro Tomé

Nomes de citação

  • Tomé, Ângelo R.

Identificadores de autor

Ciência ID
361F-D6BE-03A5
ORCID iD
0000-0001-8671-989X
Researcher Id
AAL-1963-2020
Scopus Author Id
7006456425

Moradas

  • CNC-Centro de Neurociências e Biologia Celular, Edifício da Faculdade de Medicina, Piso 1, Polo I, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2007/03/28
Concluído
 Bioquímica (Doutoramento)
Especialização em Biofísica Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Departamento de Bioquímica, Portugal
"Distribuição e Função de Receptores de ATP Extracelular em Células Cromafins Adrenais" (TESE/DISSERTAÇÃO)
 Aprovado com Louvor e Distinção
1996/06/14
Concluído
 Biologia Celular (Mestrado)
Especialização em Não Aplicável
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Departamento de Bioquímica, Portugal
"Homeostasia do Cálcio Intracelular em Células Cromafins: Regulação por Activação de Canais Iónicos e Receptores Purinérgicos" (TESE/DISSERTAÇÃO)
 Muito Bom
1990/11/14
Concluído
 Bioquímica (Licenciatura)
Especialização em Não Aplicável
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Departamento de Química, Portugal
"Estudos da Interacção de Iões de Metais Alcalinos com Reagentes de Desvio Paramagnético por RMN Multinuclear" (TESE/DISSERTAÇÃO)
 18
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1996/06/14 - Atual Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1991 - 1996/06/13 Estagiário de Investigação (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/03/28 - Atual Professor Auxiliar (Docente Universitário) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Bioquímica, Portugal
(...)
1996/06/14 - 2007/03/27 Assistente (Docente Universitário) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
(...)
1991/01/02 - 1996/06/13 Assistente Estagiário (Docente Universitário) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Química, Portugal
(...)
1989/10/01 - 1991/01/01 Monitor (Docente Universitário) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Departamento de Química, Portugal
Produções

Publicações

Artigo em revista
  1. Masella, G.; Silva, F.; Corti, E.; Azkona, G.; Madeira, M.F.; Tomé, Â.R.; Ferreira, S.G.; et al. "The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity". Molecular Psychiatry (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85182453561&partnerID=MN8TOARS.
    10.1038/s41380-024-02412-z
  2. Ana Cristina de Bem Alves; Ana Elisa Speck; Hémelin Resende Farias; Leo Meira Martins; Naiara Souza dos Santos; Gabriela Pannata; Ana Paula Tavares; et al. "The striatum drives the ergogenic effects of caffeine". Purinergic Signalling (2023): https://doi.org/10.1007/s11302-023-09922-5.
    10.1007/s11302-023-09922-5
  3. Ana P. Simões; Marina A. M. Portes; Cátia R. Lopes; Felipe Vanz; Vanessa S. Lourenço; Anna Pliássova; Ingride L. Gaspar; et al. "Adenosine A2A receptors control generalization of contextual fear in rats". Translational Psychiatry (2023): https://doi.org/10.1038/s41398-023-02613-0.
    10.1038/s41398-023-02613-0
  4. Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation". Biomolecules (2023): https://doi.org/10.3390/biom13040715.
    10.3390/biom13040715
  5. Cátia R. Lopes; Joana S. Silva; Joana Santos; Matilde S. Rodrigues; Daniela Madeira; Andreia Oliveira; Ana Moreira-de-Sá; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/8/6968.
    10.3390/ijms24086968
  6. Cátia R. Lopes; Andreia Oliveira; Ingride Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al. "Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas". Biomolecules (2023): https://doi.org/10.3390/biom13010106.
    10.3390/biom13010106
  7. Fernandes, M.Y.D.; Lopes, J.P.; Silva, H.B.; Andrade, G.M.; Cunha, R.A.; Tomé, A.R.. "Caffeic acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity in mouse hippocampal slices". Neuroscience Letters 808 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85158899696&partnerID=MN8TOARS.
    10.1016/j.neulet.2023.137292
  8. Dias, L.; Pochmann, D.; Lemos, C.; Silva, H.B.; Real, J.I.; Gonçalves, F.Q.; Rial, D.; et al. "Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress". ACS Chemical Neuroscience 14 7 (2023): 1299-1309. http://www.scopus.com/inward/record.url?eid=2-s2.0-85149749803&partnerID=MN8TOARS.
    10.1021/acschemneuro.2c00810
  9. Gonçalves, F.Q.; Valada, P.; Matos, M.; Cunha, R.A.; Tomé, A.R.. "Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals". Purinergic Signalling (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85151354718&partnerID=MN8TOARS.
    10.1007/s11302-023-09937-y
  10. Gonçalves, F.Q.; Matheus, F.C.; Silva, H.B.; Real, J.I.; Rial, D.; Rodrigues, R.J.; Oses, J.-P.; et al. "Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease". Molecular Neurobiology 60 3 (2023): 1659-1674. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144644475&partnerID=MN8TOARS.
    10.1007/s12035-022-03162-1
  11. Dias, L.; Madeira, D.; Dias, R.; Tomé, Â.R.; Cunha, R.A.; Agostinho, P.. "Aß1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes". Cellular and Molecular Life Sciences 79 8 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85135192622&partnerID=MN8TOARS.
    10.1007/s00018-022-04492-y
  12. Carvalho da Silva, António M; Lemos, Cristina; Silva, Henrique Bernardo; Ferreira, Ildete L.; Tomé, Ângelo R.; Rego, A. Cristina; Cunha, Rodrigo A.; et al. "Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer's Disease". Frontiers in Aging Neuroscience 14 (2022): http://hdl.handle.net/10316/103249.
    https://doi.org/10.3389/fnagi.2022.835885
  13. Gomez-Castro, Ferran; Zappettini, Stefania; Pressey, Jessica C.; Silva, Carla G.; Russeau, Marion; Gervasi, Nicolas; Figueiredo, Marta; et al. "Convergence of adenosine and GABA signaling for synapse stabilization during development". Science 374 6568 (2021): http://dx.doi.org/10.1126/science.abk2055.
    10.1126/science.abk2055
  14. Augusto, Elisabete; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, Marco; et al. "Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction". Neurobiology of Disease 157 (2021): 105441. http://dx.doi.org/10.1016/j.nbd.2021.105441.
    10.1016/j.nbd.2021.105441
  15. Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Queiroz; Nunes, Ana; Pochmann, Daniela; Machado, Nuno J.; Tome, Angelo; et al. "Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress". Frontiers in Cellular Neuroscience 15 (2021): http://dx.doi.org/10.3389/fncel.2021.639322.
    10.3389/fncel.2021.639322
  16. Speck, Ana E.; Aguiar, Aderbal S.; Ferreira, Samira G.; Silva, Henrique; Tome, Angelo; Agostinho, Paula; Cunha, Rodrigo A.; Prediger, Rui D.. "Exercise decreases aberrant corticostriatal plasticity in an animal model of L-DOPA-induced dyskinesia". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2021): http://dx.doi.org/10.1152/ajpregu.00295.2020.
    10.1152/ajpregu.00295.2020
  17. Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas. "Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02275-9.
    10.1007/s12035-020-02275-9
  18. Fernandes, Mara Yone D.; Dobrachinski, Fernando; Silva, Henrique B.; Lopes, João Pedro; Gonçalves, Francisco Q.; Soares, Felix A A; Porciúncula, Lisiane O.; et al. "Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices". Scientific Reports 11 1 (2021): http://hdl.handle.net/10316/105447.
    https://doi.org/10.1038/s41598-021-89964-0
  19. Cátia R. Lopes; Vanessa S. Lourenço; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas. "Use of knockout mice to explore CNS effects of adenosine". Biochemical Pharmacology (2020): 114367-114367. https://doi.org/10.1016/j.bcp.2020.114367.
    10.1016/j.bcp.2020.114367
  20. Moreira-de-Sá, Ana; Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, Paula; et al. "Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome". Neurobiology of Disease 146 (2020): 105137. http://hdl.handle.net/10316/101263.
    https://doi.org/10.1016/j.nbd.2020.105137
  21. Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Tomé, Ângelo R.; Cunha, Rodrigo A.; et al. "Role of adenosine in epilepsy and seizures". Journal of Caffeine and Adenosine Research 10 2 (2020): 45-60. http://hdl.handle.net/10451/46426.
    10.1089/caff.2019.0022
  22. Mendes, V.M.; Coelho, M.; Tomé, A.R.; Cunha, R.A.; Manadas, B.; Mendes, Vera M.; Coelho, Margarida; et al. "Validation of an LC-MS/MS Method for the quantification of caffeine and theobromine using non-matched matrix calibration curve". Molecules 24 16 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070695102&partnerID=MN8TOARS.
    10.3390/molecules24162863
  23. Carmo, M.; Gonçalves, F.Q.; Canas, P.M.; Oses, J.-P.; Fernandes, F.D.; Duarte, F.V.; Palmeira, C.M.; et al. "Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease". British Journal of Pharmacology 176 18 (2019): 3666-3680. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070072977&partnerID=MN8TOARS.
    10.1111/bph.14771
  24. Gonçalves, F.Q.; Lopes, J.P.; Silva, H.B.; Lemos, C.; Silva, A.C.; Gonçalves, N.; Tomé, Â.R.; et al. "Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine". Neurobiology of Disease 132 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070868674&partnerID=MN8TOARS.
    10.1016/j.nbd.2019.104570
  25. Tiago M. Alfaro; Diana I. Rodrigues; Ângelo R. Tomé; Rodrigo A. Cunha; Carlos Robalo Cordeiro. "Adenosine A2A receptors are up-regulated and control the activation of human alveolar macrophages". Pulmonary Pharmacology & Therapeutics 45 (2017): 90-94. https://doi.org/10.1016/j.pupt.2017.04.009.
    10.1016/j.pupt.2017.04.009
  26. Boia, R.; Elvas, F.; Madeira, M.H.; Aires, I.D.; Rodrigues-Neves, A.C.; Tralhão, P.; Szabó, E.C.; et al. "Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage". Cell Death and Disease 8 10 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041823993&partnerID=MN8TOARS.
    10.1038/cddis.2017.451
  27. Amorim, J.A.; Canas, P.M.; Tomé, A.R.; Rolo, A.P.; Agostinho, P.; Palmeira, C.M.; Cunha, R.A.. "Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer's Disease". Journal of Alzheimer's Disease 60 2 (2017): 525-536. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029613373&partnerID=MN8TOARS.
    10.3233/JAD-170356
  28. Machado, Nuno J.; Simoes, Ana Patricia; Silva, Henrique B.; Ardais, Ana Paula; Kaster, Manuella P.; Garcao, Pedro; Rodrigues, Diana I.; et al. "Caffeine reverts memory but not mood impairment in a depression-prone mouse strain with up-regulated Adenosine A(2A) receptor in hippocampal glutamate synapses". Molecular Neurobiology 54 2 (2017): 1552-1563. http://hdl.handle.net/10400.1/13201.
    10.1007/s12035-016-9774-9
  29. Li, P.; Rial, D.; Canas, P.M.; Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al. "Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory". Molecular Psychiatry 20 11 (2015): 1339-1349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946498281&partnerID=MN8TOARS.
    10.1038/mp.2014.182
  30. Li, W.; Silva, H.B.; Real, J.; Wang, Y.-M.; Rial, D.; Li, P.; Payen, M.-P.; et al. "Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models". Neurobiology of Disease 79 (2015): 70-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929459097&partnerID=MN8TOARS.
    10.1016/j.nbd.2015.03.030
  31. Kaster, M.P.; Machado, N.J.; Silva, H.B.; Nunes, A.; Ardais, A.P.; Santana, M.; Baqi, Y.; et al. "Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress". Proceedings of the National Academy of Sciences of the United States of America 112 25 (2015): 7833-7838. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934894606&partnerID=MN8TOARS.
    10.1073/pnas.1423088112
  32. Rodrigues, R.J.; Tomé, A.R.; Cunha, R.A.; Rodrigues, Ricardo J.; Tomé, Ângelo R.; Cunha, Rodrigo A.. "ATP as a multi-target danger signal in the brain". Frontiers in Neuroscience 9 APR (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928660389&partnerID=MN8TOARS.
    10.3389/fnins.2015.00148
  33. Ribeiro, P.O.; Antunes, L.M.; Nunes, C.S.; Silva, H.B.; Cunha, R.A.; Tomé, Â.R.; Ribeiro, Patrícia O.; et al. "The effects of different concentrations of the alpha2-adrenoceptor agonist medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice". Anesthesia and Analgesia 120 5 (2015): 1130-1137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937967119&partnerID=MN8TOARS.
    10.1213/ANE.0000000000000636
  34. Ribeiro, P.O.; Silva, H.B.; Tomé, Â.R.; Cunha, R.A.; Antunes, L.M.. "Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia". Lab Animal 43 10 (2014): 353-357. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964301385&partnerID=MN8TOARS.
    10.1038/laban.571
  35. Ribeiro, P.O.; Tomé, Â.R.; Silva, H.B.; Cunha, R.A.; Antunes, L.M.. "Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices". Brain Research 1560 (2014): 10-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898450346&partnerID=MN8TOARS.
    10.1016/j.brainres.2014.03.004
  36. Salamone, Alessia; Zappettini, Stefania; Grilli, Massimo; Guendalina, Paula; Tomé, Angelo R.; Chen, Jiayang; Pittaluga, Anna; et al. "Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens". Neuropharmacology 79 (2014): 488-497. http://hdl.handle.net/10316/27138.
    10.1016/j.neuropharm.2013.12.014
  37. Rial, Daniel; Castro, Adalberto A.; Machado, Nuno J.; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; et al. "Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease". PLoS ONE 9 12 (2014): http://hdl.handle.net/10316/109641.
    https://doi.org/10.1371/journal.pone.0114216
  38. Ferreira, S. G.; Gonçalves, F. Q.; Marques, J. M.; Tomé, Â. R.; Rodrigues, R. J.; Nunes-Correia, I.; Ledent, C.; et al. "Presynaptic A2A adenosine receptors dampen CB1 cannabinoid receptor-mediated inhibition of corticostriatal glutamatergic transmission". British Journal of Pharmacology 172 4 (2014): 1074-1086. http://hdl.handle.net/10316/27660.
    https://doi.org/10.1111/bph.12970
  39. Zappettini, Stefania; Grilli, Massimo; Olivero, Guendalina; Chen, Jiayang; Padolecchia, Cristina; Pittaluga, Anna; Tomé, Ângelo R.; et al. "Nicotinic a7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens". Frontiers in Cellular Neuroscience 8 OCT (2014): http://hdl.handle.net/10316/109425.
    https://doi.org/10.3389/fncel.2014.00332
  40. Silva, C.G.; Métin, C.; Fazeli, W.; Machado, N.J.; Darmopil, S.; Launay, P.-S.; Ghestem, A.; et al. "Adenosine receptor antagonists including caffeine alter fetal brain development in mice". Science Translational Medicine 5 197 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883887587&partnerID=MN8TOARS.
    10.1126/scitranslmed.3006258
  41. Garção, P.; Szabõ, E.C.; Wopereis, S.; Castro, A.A.; Tomé, A.R.; Prediger, R.D.; Cunha, R.A.; Agostinho, P.; Köfalvi, A.. "Functional interaction between pre-synaptic a6ß2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum". British Journal of Pharmacology 169 7 (2013): 1600-1611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880322083&partnerID=MN8TOARS.
    10.1111/bph.12234
  42. Simões, A.P.; Duarte, J.A.; Agasse, F.; Canas, P.M.; Tomé, A.R.; Agostinho, P.; Cunha, R.A.. "Blockade of adenosine A2A receptors prevents interleukin-1ß-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway". Journal of Neuroinflammation 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865050131&partnerID=MN8TOARS.
    10.1186/1742-2094-9-204
  43. Gomes, C.V.; Kaster, M.P.; Tomé, A.R.; Agostinho, P.M.; Cunha, R.A.. "Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration". Biochimica et Biophysica Acta - Biomembranes 1808 5 (2011): 1380-1399. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953220421&partnerID=MN8TOARS.
    10.1016/j.bbamem.2010.12.001
  44. Rebola, N.; Simões, A.P.; Canas, P.M.; Tomé, A.R.; Andrade, G.M.; Barry, C.E.; Agostinho, P.M.; Lynch, M.A.; Cunha, R.A.. "Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction". Journal of Neurochemistry 117 1 (2011): 100-111. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952548073&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07178.x
  45. Antunes, Célia M.; Rosário, Luís M.; Barbosa, Rui M.; Silva, Amélia S.; Baldeiras, Inês E.; Tomé, Ângelo R.; Santos, Rosa M.; et al. "Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in the absence of functional K-ATP channels". Endocrine Journal 55 4 (2009): 639-650. http://hdl.handle.net/10174/1525.
    10.1507/endocrj.K07E-131
  46. Silva, A.M.; Rodrigues, R.J.; Tomé, Â.R.; Cunha, R.A.; Misler, S.; Rosário, L.M.; Santos, R.M.. "Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic ß cells". Pancreas 36 3 (2008): 279-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149170881&partnerID=MN8TOARS.
    10.1097/MPA.0b013e31815a8473
  47. Tomé, Ângelo R.; Castro, Enrique; Santos, Rosa M.; Rosário, Luís M.; Tomé, A.R.; Castro, E.; Santos, R.M.; Rosário, L.M.. "Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP". BMC Neuroscience 8 (2007): http://hdl.handle.net/10316/12647.
    10.1186/1471-2202-8-41
  48. Tomé, Ângelo R.; Castro, Enrique; Santos, Rosa M.; Rosário, Luís M.; Tomé, A.R.; Castro, E.; Santos, R.M.; Rosário, L.M.. "Functional distribution of Ca2+-coupled P2 purinergic receptors among adrenergic and noradrenergic bovine adrenal chromaffin cells". BMC Neuroscience 8 (2007): http://hdl.handle.net/10316/12648.
    10.1186/1471-2202-8-39
  49. Fonseca, C. P.; Montezinho, L. P.; Nabais, C.; Tomé, A. R.; Freitas, H.; Geraldes, C. F. G. C.; Castro, M. M. C. A.; et al. "Effects of Li+ transport and intracellular binding on Li+/Mg2+ competition in bovine chromaffin cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1691 2-3 (2004): 79-90. http://hdl.handle.net/10316/3866.
    https://doi.org/10.1016/j.bbamcr.2003.12.005
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    10.1078/0171-9335-00128
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Capítulo de livro
  1. Salgado, A.P.; Santos, R.M.; Pereira, F.C.; Fernandes, A.P.; Tome, Angelo R.; Flatt, P.R.; Ramasamy R.; Rosário, L.M.. "Glucose Signalling in Clonal Insulin-Secreting BRIN-BD11 Cells: Role of Cytosolic Ca2+ and Redox State". In Molecular Mechanisms of Transcellular Signaling: From Membrane Receptors to Transcription Factors, editado por Thiery, J.P., 212-220. Amsterdam, Países Baixos: IOS Press, 1999.
    Publicado