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Luís Gales, born in 1971, graduated in Chemical Engineering from the Faculty of Engineering of the University of Porto (FEUP) in 1994. In 1995, having been awarded a Ph.D. Scholarship from FCT, he pursued his Ph.D. in Chemical Engineering, completing it in 2000 at the University of Porto (FEUP) under the supervision of Carlos Costa and Adélio Mendes . He served as a Lecturer at Instituto de Ciências Biomédicas Abel Salazar (ICBAS) at the University of Porto (UP) from 2000 to 2002 and later as an Assistant Professor in the Molecular Biology Department of ICBAS from 2002 to 2007. Since 2007, he has been an Associate Professor of Biophysics at ICBAS and currently holds the position of sub-director of the Molecular Biology Department. He was elected as a member of the Council of Representatives and of the Pedagogical Council of ICBAS. Luís Gales employs biophysical techniques to explore the molecular mechanisms behind protein self-assembly, ultimately resulting in the development of amyloid. His ultimate goal is to suggest innovative diagnostic and therapeutic approaches for neurodegenerative diseases, particularly transthyretin-related amyloidosis. He has contributed to over 100 publications (h-index of 32).
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Identificação

Identificação pessoal

Nome completo
Luís Miguel Gales Pereira Pinto

Nomes de citação

  • Gales, Luís

Identificadores de autor

Ciência ID
371C-F2FE-9964
ORCID iD
0000-0002-8352-6539
Google Scholar ID
https://www.scopus.com/authid/detail.uri?authorId=6602831499
Scopus Author Id
6602831499

Telefones

Telefone
  • 220408800 (Profissional)

Moradas

  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biofísica
Formação
Grau Classificação
1995 - 2000
Concluído
 Engenharia Química (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
 Aprovado por unanimidade
1989/09/01 - 1994/07/30
Concluído
 Engenharia Química (Licenciatura)
Especialização em Biopolímeros
Universidade do Porto Faculdade de Engenharia, Portugal
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2000 - Atual Investigador (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/02/01 - Atual Professor Associado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2002/02 - 2007/02 Professor Auxiliar (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projetos

Projeto

Designação Financiadores
2021/01/01 - 2024/02/29 PhaseAGE - Excellence Hub on Phase Transitions in Aging and Age-Related Disorders
GRANT_NUMBER: 952334
Investigador
Em curso
2018/07/01 - 2022/06/30 Dipeptide Crystals as Biomaterials for Gas Purification
PTDC/QUI-QFI/29914/2017
Investigador
Associação para a Inovação e Desenvolvimento da FCT
Em curso
2018/07/01 - 2021/06/30 Cyanobacterial extracellular polymeric substances (EPS): From the genes to the industrial toolbox
PTDC/BIA-MIC/28779/2017
Investigador
Associação para a Inovação e Desenvolvimento da FCT
Em curso
2016/05/01 - 2019/12/31 Porto Neurosciences and Neurologic Disease Research Initiative at i3S
NORTE-01-0145-FEDER-000008
Investigador
Em curso
2015/01/01 - 2018/06/30 Setting a rational screening program for transthyretin-Aß binding stabilizing compounds that may lead to potential Alzheimer´s disease modulating drugs.
Projeto Coordenado 20140330-31-32-33-34
Investigador
Fundació la Marató de TV3
Concluído
2015/01/01 - 2016/01/01 Caracterização físico-química de vedantes de cortiça
cork1
Investigador responsável
M.A.Silva Cortiças, Lda
Concluído
2013/07/01 - 2015/10/31 Characterization and application of the novel molinate hydrolase (MolA) in bioremediation processes
info:eu-repo/grantAgreement/FCT/COMPETE/130494/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/01 - 2012/06/30 The Macromolecular Structure of Suberin
info:eu-repo/grantAgreement/FCT/3599-PPCDT/70589/PT
Investigador
Fundação para a Ciência e a Tecnologia
2008/02/01 - 2011/12/31 Synthesis of conducting nanostructures by selective metal deposition on amyloid fibers
PTDC/CTM/64191/2006
Investigador responsável
Associação para a Inovação e Desenvolvimento da FCT
Concluído
2007/11/01 - 2011/04/30 Characterization of a new metabolic pathway: mineralization of the herbicide molinate
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/66653/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2005/07/01 - 2008/11/30 Familial Amyloidotic Polineuropathy – a contribution for a therapeutic strategy
POCI/SAU-NEU/58735/2004
Investigador
Associação para a Inovação e Desenvolvimento da FCT
Concluído
2003/10/01 - 2007/03/31 Amyloid fibres: searching for therapeutical and diagnosis agents
info:eu-repo/grantAgreement/FCT/POCI/44821/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2001/04/01 - 2004/03/31 Transthyretin (TTR) interaction with the receptor for advanced glycation end products (RAGE): a possible pathway leading to neurodegeneration
info:eu-repo/grantAgreement/FCT/POCI/35735/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2000/11/01 - 2002/03/14 Amyloid fibers
Praxis/P/SAU/13236/1998
Investigador
Associação para a Inovação e Desenvolvimento da FCT
Concluído
Produções

Publicações

Artigo em conferência
  1. Afonso, R.; Durão, J.; Gales, L.. "Dipeptide crystals as excellent permselective materials". 2011.
  2. Gales, Luís. "Dipeptide crystals: perfect pores for permeable membranes". 2010.
Artigo em revista
  1. Leite, José P.; Costa-Rodrigues, Diogo; Gales, Luís. "Inhibitors of Transthyretin Amyloidosis: How to Rank Drug Candidates Using X-ray Crystallography Data". Molecules 29 4 (2024): 895. http://dx.doi.org/10.3390/molecules29040895.
    Publicado • 10.3390/molecules29040895
  2. Rodrigues, T.; Mota, R.; Gales, L.; Tamagnini, P.; Campo-Deaño, L.. "Microrheological characterisation of Cyanoflan in human blood plasma". Carbohydrate Polymers 326 (2024): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179587749&doi=10.1016%2fj.carbpol.2023.121575&partnerID=40&md5=870db2d780cfdabf34a22ddb6ba122be.
    10.1016/j.carbpol.2023.121575
  3. José P. Leite; Frederico Lourenço; Rute Oliveira; Sérgio F. Sousa; Marta V. Mendes; Luís Gales. "Crystal structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG". Journal of Structural Biology (2023): https://doi.org/10.1016/j.jsb.2023.108038.
    10.1016/j.jsb.2023.108038
  4. Gales, Luís. "Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets". Neural Regeneration Research 19 3 (2023): 497-498. http://dx.doi.org/10.4103/1673-5374.380897.
    10.4103/1673-5374.380897
  5. Klaram, Rotchana; Dethoup, Tida; Machado, Fátima P.; Gales, Luís; Kumla, Decha; Hafez Ghoran, Salar; Sousa, Emília; et al. "Pentaketides and 5-p-Hydroxyphenyl-2-pyridone Derivative from the Culture Extract of a Marine Sponge-Associated Fungus Hamigera avellanea KUFA0732". Marine Drugs 21 6 (2023): 344. http://dx.doi.org/10.3390/md21060344.
    10.3390/md21060344
  6. Machado, Fátima P.; Rodrigues, Inês C.; Georgopolou, Aikaterini; Gales, Luís; Pereira, José A.; Costa, Paulo M.; Mistry, Sharad; et al. "New Hybrid Phenalenone Dimer, Highly Conjugated Dihydroxylated C28 Steroid and Azaphilone from the Culture Extract of a Marine Sponge-Associated Fungus, Talaromyces pinophilus KUFA 1767". Marine Drugs 21 3 (2023): 194. http://dx.doi.org/10.3390/md21030194.
    10.3390/md21030194
  7. Leite, José P.; Figueira, Flávio; Mendes, Ricardo F.; Almeida Paz, Filipe A.; Gales, Luís. "Metal–Organic Frameworks as Sensors for Human Amyloid Diseases". ACS Sensors 8 3 (2023): 1033-1053. http://dx.doi.org/10.1021/acssensors.2c02741.
    10.1021/acssensors.2c02741
  8. Soares, Iris; Rodrigues, Inês; da Costa, Paulo Martins; Gales, Luís. "Antibacterial and Antibiofilm Properties of Self-Assembled Dipeptide Nanotubes". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/1/328.
    10.3390/ijms24010328
  9. Ferreira, Maria J.; Rodrigues, Tony A.; Pedrosa, Ana G.; Gales, Luís; Salvador, Armindo; Francisco, Tânia; Azevedo, Jorge E.. "The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis". Redox Biology 63 (2023): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160316858&doi=10.1016%2fj.redox.2023.102764&partnerID=40&md5=f67debb9dd2ac64cb43d7f2854f9df0a.
    10.1016/j.redox.2023.102764
  10. Biernacki, K.; Lopes, J.; Afonso, R.; Mendes, A.; Gales, L.; Magalhães, A.L.. "Selective adsorption and separation of light hydrocarbon gases in VI/IV dipeptide crystals". Microporous and Mesoporous Materials 345 (2022): 112284. http://dx.doi.org/10.1016/j.micromeso.2022.112284.
    10.1016/j.micromeso.2022.112284
  11. Fátima P. Machado; Inês C. Rodrigues; Luís Gales; José A. Pereira; Paulo M. Costa; Tida Dethoup; Sharad Mistry; et al. "New Alkylpyridinium Anthraquinone, Isocoumarin, C-Glucosyl Resorcinol Derivative and Prenylated Pyranoxanthones from the Culture of a Marine Sponge-Associated Fungus, Aspergillus stellatus KUFA 2017". Marine Drugs (2022): https://doi.org/10.3390/md20110672.
    10.3390/md20110672
  12. Cardoso, Joana; Freitas-Silva, Joana; Durães, Fernando; Carvalho, Diogo Teixeira; Gales, Luís; Pinto, Madalena; Sousa, Emília; Pinto, Eugénia. "Antifungal Activity of a Library of Aminothioxanthones". Antibiotics 11 11 (2022): 1488. http://dx.doi.org/10.3390/antibiotics11111488.
    10.3390/antibiotics11111488
  13. Rodrigues, T.; Mota, R.; Gales, L.; Campo-Deaño, L.. "Understanding the complex rheology of human blood plasma". Journal of Rheology 66 4 (2022): 761-774. http://dx.doi.org/10.1122/8.0000442.
    10.1122/8.0000442
  14. Cotrina, Ellen Y.; Santos, Luis Miguel; Rivas, Josep; Blasi, Daniel; Leite, José Pedro; Liz, Márcia A.; Busquets, Maria Antònia; et al. "Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease". European Journal of Medicinal Chemistry 226 (2021): 113847. http://dx.doi.org/10.1016/j.ejmech.2021.113847.
    10.1016/j.ejmech.2021.113847
  15. José P. Leite; Marta G. Lete; Susan B. Fowler; Ana Gimeno; Juliana F. Rocha; Sérgio F. Sousa; Carl I. Webster; Jesús J. Jiménez-Bar`bero; Luís Gales. "Aß31–35 Decreases Neprilysin-Mediated Alzheimer’s Amyloid-ß Peptide Degradation". ACS Chemical Neuroscience (2021): https://doi.org/10.1021/acschemneuro.1c00432.
    10.1021/acschemneuro.1c00432
  16. Long, Solida; Furlani, Izadora L.; Oliveira, Juliana M. de; Resende, Diana I. S. P.; Silva, Artur M. S.; Gales, Luís; Pereira, José A.; et al. "Determination of the Absolute Configuration of Bioactive Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones and Study of Their In Vitro Metabolic Profile". Molecules 26 16 (2021): 5070. http://dx.doi.org/10.3390/molecules26165070.
    10.3390/molecules26165070
  17. Fernando Durães; Andreia Palmeira; Bárbara Cruz; Joana Freitas-Silva; Nikoletta Szemerédi; Luís Gales; Paulo Martins da Costa; et al. "Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors". Pharmaceuticals 14 6 (2021): 572-572. https://doi.org/10.3390/ph14060572.
    10.3390/ph14060572
  18. Fernando Durães; Patrícia M. A. Silva; Pedro Novais; Isabel Amorim; Luís Gales; Cátia I. C. Esteves; Samuel Guieu; et al. "Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity". Molecules 26 11 (2021): 3315-3315. https://doi.org/10.3390/molecules26113315.
    10.3390/molecules26113315
  19. Solida Long; Joana B. Loureiro; Carla Carvalho; Luís Gales; Lucília Saraiva; Madalena M. M. Pinto; Ploenthip Puthongking; Emília Sousa. "Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53". Molecules 26 6 (2021): 1637-1637. https://doi.org/10.3390/molecules26061637.
    10.3390/molecules26061637
  20. Gales, Luís. "1,3-Dioxepine and spiropyran derivatives of viomellein and other dimeric naphthopyranones from cultures of Aspergillus elegans KUFA0015 and their antibacterial activity". Phytochemistry 181 (2021): 112575-112575. http://dx.doi.org/10.1016/j.phytochem.2020.112575.
    10.1016/j.phytochem.2020.112575
  21. Ellen Y. Cotrina; Ângela Oliveira; José Pedro Leite; Jordi Llop; Luis Gales; Jordi Quintana; Isabel Cardoso; Gemma Arsequell. "Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21197166.
    10.3390/ijms21197166
  22. Gales, Luís. "Dissection of the key steps of amyloid-ß peptide 1-40 fibrillogenesis.". International journal of biological macromolecules (2020): https://doi.org/10.1016/j.ijbiomac.2020.08.023.
    10.1016/j.ijbiomac.2020.08.023
  23. Gales, Luís. "Synthesis of a Small Library of Nature-Inspired Xanthones and Study of Their Antimicrobial Activity.". Molecules (Basel, Switzerland) (2020): https://europepmc.org/articles/PMC7287773.
    10.3390/molecules25102405
  24. Phyo, Y.Z.; Teixeira, J.; Tiritan, M.E.; Cravo, S.; Palmeira, A.; Gales, L.; Silva, A.M.S.; et al. "New chiral stationary phases for liquid chromatography based on small molecules: Development, enantioresolution evaluation and chiral recognition mechanisms". Chirality 32 1 (2020): 81-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075466338&partnerID=MN8TOARS.
    10.1002/chir.23142
  25. Ricardo F. Mendes; Flávio Figueira; José P. Leite; Luís Gales; Filipe A. Almeida Paz. "Metal–organic frameworks: a future toolbox for biomedicine?". Chemical Society Reviews (2020): https://doi.org/10.1039/D0CS00883D.
    10.1039/D0CS00883D
  26. Rute Pereira; Telma Barbosa; Luís Gales; Elsa Oliveira; Rosário Santos; Jorge Oliveira; Mário Sousa. "Clinical and Genetic Analysis of Children with Kartagener Syndrome". Cells (2019): https://doi.org/10.3390/cells8080900.
    10.3390/cells8080900
  27. Luís Gales. "Tegsedi (Inotersen): An Antisense Oligonucleotide Approved for the Treatment of Adult Patients with Hereditary Transthyretin Amyloidosis". Pharmaceuticals 12 2 (2019): 78-78. https://doi.org/10.3390/ph12020078.
    10.3390/ph12020078
  28. José P. Leite; Diogo Rodrigues; Susana Ferreira; Flávio Figueira; Filipe A. Almeida Paz; Luís Gales. "Mesoporous Metal–Organic Frameworks as Effective Nucleating Agents in Protein Crystallography". Crystal Growth & Design (2019): https://doi.org/10.1021/acs.cgd.8b01444.
    10.1021/acs.cgd.8b01444
  29. Berta N. Estevinho; Rita Mota; José P. Leite; Paula Tamagnini; Luís Gales; Fernando Rocha. "Application of a cyanobacterial extracellular polymeric substance in the microencapsulation of vitamin B12". Powder Technology 343 (2019): 644-651. https://doi.org/10.1016/j.powtec.2018.11.079.
    10.1016/j.powtec.2018.11.079
  30. Decha Kumla; Tida Dethoup; Luis Gales; José A Pereira; Joana Freitas-Silva; Paulo Martins da Costa; Artur M. S. Silva; Madalena M. M. Pinto; Anake Kijjoa. "Erubescensoic Acid, a New Polyketide and a Xanthonopyrone SPF-3059-26 from the Culture of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA 0220 and Antibacterial Activity Evaluation of Some of Its Constituents". Molecules (2019): http://www.mdpi.com/1420-3049/24/1/208.
    10.3390/molecules24010208
  31. Gales, Luís. "Fluorescence properties of the amyloid indicator dye thioflavin T in constrained environments". Dyes and Pigments 160 (2019): 64-70. http://www.sciencedirect.com/science/article/pii/S0143720818300925.
    https://doi.org/10.1016/j.dyepig.2018.07.049
  32. Reis, A.C.; Kolvenbach, B.A.; Chami, M.; Gales, L.; Egas, C.; Corvini, P.F.-X.; Nunes, O.C.. "Comparative genomics reveals a novel genetic organization of the sad cluster in the sulfonamide-degrader 'Candidatus Leucobacter sulfamidivorax' strain GP". BMC genomics 20 1 (2019): 885-885. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075496018&partnerID=MN8TOARS.
    10.1186/s12864-019-6206-z
  33. Joana Durão; Nuno Vale; Salomé Gomes; Paula Gomes; Cristina C. Barrias; Luís Gales. "Nitric Oxide Release from Antimicrobial Peptide Hydrogels for Wound Healing". Biomolecules (2018): https://doi.org/10.3390/biom9010004.
    10.3390/biom9010004
  34. Leite JP; Gales L. "Alzheimer's Aß1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Aß product.". FEBS letters (2018): http://europepmc.org/abstract/med/30403288.
    10.1002/1873-3468.13285
  35. Buttachon S; Ramos AA; Inácio Â; Dethoup T; Gales L; Lee M; Costa PM; et al. "Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Aspergillus candidus KUFA0062.". Marine drugs (2018): http://europepmc.org/abstract/med/29642369.
    10.3390/md16040119
  36. Pereira, S.B.; Santos, M.; Leite, J.P.; Flores, C.; Eisfeld, C.; Büttel, Z.; Mota, R.; et al. "The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803". MicrobiologyOpen (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060602531&partnerID=MN8TOARS.
    10.1002/mbo3.753
  37. Gales, Luís. "Transport Properties of Light Gases in Nanochannels of L–Leu-L-Ser Dipeptide Crystals: A Comparative Study by Molecular Dynamics Simulations". ChemistrySelect 3 20 (2018): 5517-5525. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047658538&doi=10.1002%2fslct.201800559&partnerID=40&md5=e30d90e9495e4f48afa48cd247128a7c.
    10.1002/slct.201800559
  38. Gales, Luís. "Chromone Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA0220 and Their Antibacterial Activity". Marine drugs (2018): https://doi.org/10.3390/md16080289.
    10.3390/md16080289
  39. May Zin, W.W.; Buttachon, S.; Dethoup, T.; Pereira, J.A.; Gales, L.; Inácio, Â.; Costa, P.M.; et al. "Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA 0006". Phytochemistry 141 (2017): 86-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019971424&partnerID=MN8TOARS.
    10.1016/j.phytochem.2017.05.015
  40. Noinart, J.; Buttachon, S.; Dethoup, T.; Gales, L.; Pereira, J.A.; Urbatzka, R.; Freitas, S.; et al. "A new ergosterol analog, a new bis-anthraquinone and anti-obesity activity of anthraquinones from the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207". Marine Drugs 15 5 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019610771&partnerID=MN8TOARS.
    10.3390/md15050139
  41. Kumla, D.; Aung, T.S.; Buttachon, S.; Dethoup, T.; Gales, L.; Pereira, J.A.; Inácio, Â.; et al. "A new dihydrochromone dimer and other secondary metabolites from cultures of the marine sponge-associated fungi Neosartorya fennelliae KUFA 0811 and Neosartorya tsunodae KUFC 9213". Marine Drugs 15 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85039868505&partnerID=MN8TOARS.
    10.3390/md15120375
  42. Gales, Luís. "Cyanobacterium-Derived Extracellular Carbohydrate Polymer for the Controlled Delivery of Functional Proteins". Macromolecular Bioscience 17 2 (2017): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988663806&doi=10.1002%2fmabi.201600206&partnerID=40&md5=ceaa0f9926b0662d2f3449cdea2e9fa9.
    10.1002/mabi.201600206
  43. Gales, Luís. "New polyketides and new benzoic acid derivatives from the marine sponge-associated fungus Neosartorya quadricincta KUFA 0081". Marine Drugs 14 7 (2016): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979223422&partnerID=40&md5=b2920bb0e367afb7acb1be0c38b49fe4.
    10.3390/md14070134
  44. Carvalho, N.; Coelho, E.; Gales, L.; Costa, V.; Teixeira, J.A.; Moradas-Ferreira, P.. "Production of orotic acid by a Klura3d mutant of Kluyveromyces lactis". Journal of Bioscience and Bioengineering 121 6 (2016): 625-630. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950152580&partnerID=MN8TOARS.
    10.1016/j.jbiosc.2015.10.008
  45. Lopes, A.R.; Sousa, V.M.; Estevinho, B.N.; Leite, J.P.; Moreira, N.F.F.; Gales, L.; Rocha, F.; Nunes, O.C.. "Production of microparticles of molinate degrading biocatalysts using the spray drying technique". Chemosphere 161 (2016): 61-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978389071&partnerID=MN8TOARS.
    10.1016/j.chemosphere.2016.07.006
  46. Afonso, R.; Gales, L.; Mendes, A.. "Kinetic derivation of common isotherm equations for surface and micropore adsorption". Adsorption 22 7 (2016): 963-971. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982156308&partnerID=MN8TOARS.
    10.1007/s10450-016-9803-z
  47. Gales, Luís. "Secondary Metabolites from the Culture of the Marine Sponge-Associated Fungi Talaromyces tratensis and Sporidesmium circinophorum". Planta Medica 82 9-10 (2016): 888-896. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976629140&partnerID=40&md5=fdf452b5ed468a7eb08cc161370d69c5.
    10.1055/s-0042-103687
  48. Gales, Luís. "New cyclotetrapeptides and a new diketopiperzine derivative from the marine sponge-associated fungus Neosartorya glabra KUFA 0702". Marine Drugs 14 7 (2016): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979518314&partnerID=40&md5=175f5e230345881cd76cb9937bd799ef.
    10.3390/md14070136
  49. Gales, Luís. "A surface thermodynamics approach to modelling single-file adsorption in ultramicroporous materials". Microporous and Mesoporous Materials 225 (2016): 543-551. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958214502&partnerID=40&md5=43c6a607b97ed5937bf15ecdca0402f7.
    10.1016/j.micromeso.2016.01.041
  50. Gales, Luís. "Structure-Guided Engineering of Molinate Hydrolase for the Degradation of Thiocarbamate Pesticides". PLoS ONE 10 4 (2015): e0123430-e0123430. http://dx.doi.org/10.1371%2Fjournal.pone.0123430.
    10.1371/journal.pone.0123430
  51. Durão, J.; Gales, L.. "Peptide self-assembly for therapeutic applications". Current Organic Chemistry 19 19 (2015): 1874-1881. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940913846&partnerID=MN8TOARS.
    10.2174/1385272819666150608220036
  52. Gales, Luís. "A New Meroditerpene and a New Tryptoquivaline Analog from the Algicolous Fungus Neosartorya takakii KUFC 7898". Marine Drugs (2015): http://www.mdpi.com/1660-3397/13/6/3776.
    10.3390/md13063776
  53. Gales, Luís. "Decreasing the toxicity of paraquat through the complexation with sodium salicylate: Stoichiometric analysis". Toxicology 336 (2015): 96-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940055375&partnerID=40&md5=83e284e965853a9c24fbf97b3dcf059d.
    10.1016/j.tox.2015.08.005
  54. Emami, S.; Paz, F.A.A.; Mendes, A.; Gales, L.. "Toward the construction of 3D dipeptide-metal frameworks". Crystal Growth and Design 14 9 (2014): 4777-4780. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906875641&partnerID=MN8TOARS.
    10.1021/cg500925x
  55. Gales, Luís. "New Isocoumarin Derivatives and Meroterpenoids from the Marine Sponge-Associated Fungus Aspergillus similanensis sp. nov. KUFA 0013". Marine Drugs (2014): http://www.mdpi.com/1660-3397/12/10/5160.
    10.3390/md12105160
  56. Ferreira, N.; Pereira-Henriques, A.; Attar, A.; Klärner, F.-G.; Schrader, T.; Bitan, G.; Gales, L.; Saraiva, M.J.; Almeida, M.R.. "Molecular Tweezers Targeting Transthyretin Amyloidosis". Neurotherapeutics 11 2 (2014): 450-461. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899492342&partnerID=MN8TOARS.
    10.1007/s13311-013-0256-8
  57. Afonso, R.; Mendes, A.; Gales, L.. "Hydrophobic dipeptide crystals: A promising Ag-free class of ultramicroporous materials showing argon/oxygen adsorption selectivity". Physical Chemistry Chemical Physics 16 36 (2014): 19386-19393. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906536100&partnerID=MN8TOARS.
    10.1039/c4cp02085e
  58. Cruz, C.F.; Fernandes, M.M.; Gomes, A.C.; Coderch, L.; Martí, M.; Méndez, S.; Gales, L.; et al. "Keratins and lipids in ethnic hair". International Journal of Cosmetic Science 35 3 (2013): 244-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877800810&partnerID=MN8TOARS.
    10.1111/ics.12035
  59. Azevedo, C.M.G.; Afonso, C.M.M.; Soares, J.X.; Reis, S.; Sousa, D.; Lima, R.T.; Vasconcelos, M.H.; et al. "Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models". European Journal of Medicinal Chemistry 69 (2013): 798-816. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885009924&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.012
  60. Mota, R.; Guimarães, R.; Büttel, Z.; Rossi, F.; Colica, G.; Silva, C.J.; Santos, C.; et al. "Production and characterization of extracellular carbohydrate polymer from Cyanothece sp. CCY 0110". Carbohydrate Polymers 92 2 (2013): 1408-1415. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869866310&partnerID=MN8TOARS.
    10.1016/j.carbpol.2012.10.070
  61. Durão, J.; Gales, L.. "Guest diffusion in dipeptide crystals". CrystEngComm 15 8 (2013): 1532-1535. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873310299&partnerID=MN8TOARS.
    10.1039/c2ce26392k
  62. Durão, J.; Gales, L.. "Permeation of light gases through hexagonal ice". Materials 5 9 (2012): 1593-1601. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866151978&partnerID=MN8TOARS.
    10.3390/ma5091593
  63. Gomes, N.M.; Dethoup, T.; Singburaudom, N.; Gales, L.; Silva, A.M.S.; Kijjoa, A.. "Eurocristatine, a new diketopiperazine dimer from the marine sponge-associated fungus Eurotium cristatum". Phytochemistry Letters 5 4 (2012): 717-720. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869500048&partnerID=MN8TOARS.
    10.1016/j.phytol.2012.07.010
  64. Afonso, R.; Mendes, A.; Gales, L.. "Peptide-based solids: Porosity and zeolitic behavior". Journal of Materials Chemistry 22 5 (2012): 1709-1723. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855666967&partnerID=MN8TOARS.
    10.1039/c1jm13568f
  65. Buttachon, S.; Chandrapatya, A.; Manoch, L.; Silva, A.; Gales, L.; Bruyère, C.; Kiss, R.; Kijjoa, A.. "Sartorymensin, a new indole alkaloid, and new analogues of tryptoquivaline and fiscalins produced by Neosartorya siamensis (KUFC 6349)". Tetrahedron 68 15 (2012): 3253-3262. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858707940&partnerID=MN8TOARS.
    10.1016/j.tet.2012.02.024
  66. Ferreira, C.; Crespo, R.; Martins, P.M.; Gales, L.; Rocha, F.; Damas, A.M.. "Small temperature oscillations promote protein crystallization". CrystEngComm 13 8 (2011): 3051-3056. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953168840&partnerID=MN8TOARS.
    10.1039/c0ce00550a
  67. Kijjoa, A.; Santos, S.; Dethoup, T.; Manoch, L.; Almeida, A.P.; Vasconcelos, M.H.; Silva, A.; Gales, L.; Herz, W.. "Sartoryglabrins, analogs of ardeemins, from Neosartorya glabra". Natural Product Communications 6 6 (2011): 807-812. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959215170&partnerID=MN8TOARS.
  68. Duarte, M.; Ferreira-da-Silva, F.; Lünsdorf, H.; Junca, H.; Gales, L.; Pieper, D.H.; Nunes, O.C.. "Gulosibacter molinativorax ON4 T molinate hydrolase, a novel cobalt-dependent amidohydrolase". Journal of Bacteriology 193 20 (2011): 5810-5816. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053604140&partnerID=MN8TOARS.
    10.1128/JB.05054-11
  69. Castro-Rodrigues, A.F.; Gales, L.; Saraiva, M.J.; Damas, A.M.. "Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils". Acta Crystallographica Section D: Biological Crystallography 67 12 (2011): 1035-1044. http://www.scopus.com/inward/record.url?eid=2-s2.0-82455198838&partnerID=MN8TOARS.
    10.1107/S090744491104491X
  70. Neves, M.P.; Cidade, H.; Pinto, M.; Silva, A.M.S.; Gales, L.; Damas, A.M.; Lima, R.T.; Vasconcelos, M.H.; Nascimento, M.D.S.J.. "Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis". European Journal of Medicinal Chemistry 46 6 (2011): 2562-2574. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955635866&partnerID=MN8TOARS.
    10.1016/j.ejmech.2011.03.047
  71. Crespo, R.; Martins, P.M.; Gales, L.; Rocha, F.; Damas, A.M.. "Potential use of ultrasound to promote protein crystallization". Journal of Applied Crystallography 43 6 (2010): 1419-1425. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649524231&partnerID=MN8TOARS.
    10.1107/S0021889810040951
  72. Ferreira, M.J.F.; Fernandes, V.R.; Gales, L.; Rangel, C.M.; Pinto, A.M.F.R.. "Effects of the addition of an organic polymer on the hydrolysis of sodium tetrahydroborate in batch reactors". International Journal of Hydrogen Energy 35 20 (2010): 11456-11469. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957331018&partnerID=MN8TOARS.
    10.1016/j.ijhydene.2010.07.079
  73. Freitas, V.L.S.; Gomes, J.R.B.; Gales, L.; Damas, A.M.; Ribeiro Da Silva, M.D.M.C.. "Experimental and computational studies on the structural and thermodynamic properties of two sulfur heterocyclic keto compounds". Journal of Chemical and Engineering Data 55 11 (2010): 5009-5017. http://www.scopus.com/inward/record.url?eid=2-s2.0-78449295503&partnerID=MN8TOARS.
    10.1021/je100603q
  74. Afonso, R.V.; Durão, J.; Mendes, A.; Damas, A.M.; Gales, L.. "Dipeptide crystals as excellent permselective materials: Sequential exclusion of argon, nitrogen, and oxygen". Angewandte Chemie - International Edition 49 17 (2010): 3034-3036. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951172416&partnerID=MN8TOARS.
    10.1002/anie.201000007
  75. Ferreira, M.J.F.; Gales, L.; Fernandes, V.R.; Rangel, C.M.; Pinto, A.M.F.R.. "Alkali free hydrolysis of sodium borohydride for hydrogen generation under pressure". International Journal of Hydrogen Energy 35 18 (2010): 9869-9878. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956174818&partnerID=MN8TOARS.
    10.1016/j.ijhydene.2010.02.121
  76. Sousa, E.; Paiva, A.; Nazareth, N.; Gales, L.; Damas, A.M.; Nascimento, M.S.J.; Pinto, M.. "Bromoalkoxyxanthones as promising antitumor agents: Synthesis, crystal structure and effect on human tumor cell lines". European Journal of Medicinal Chemistry 44 9 (2009): 3830-3835. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650578617&partnerID=MN8TOARS.
    10.1016/j.ejmech.2009.04.011
  77. Gales, L.; Castanheiro, R.A.P.; Pinto, M.M.M.; Damas, A.M.. "1-Hydr-oxy-3-(3-methyl-but-2-en-yloxy)xanthone". Acta Crystallographica Section E: Structure Reports Online 65 11 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70449450672&partnerID=MN8TOARS.
    10.1107/S1600536809040069
  78. Mairal, T.; Nieto, J.; Pinto, M.; Almeida, M.R.; Gales, L.; Ballesteros, A.; Barluenga, J.; et al. "Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors". PLoS ONE 4 1 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-59249100931&partnerID=MN8TOARS.
    10.1371/journal.pone.0004124
  79. Jordana, X.; Galtés, I.; Couto, A.R.; Gales, L.; Damas, M.; Lima, M.; Bruges-Armas, J.. "The coexistence of ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis - A postmortem diagnosis". Clinical Rheumatology 28 3 (2009): 353-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-59749101392&partnerID=MN8TOARS.
    10.1007/s10067-008-1068-9
  80. Ferreira, M.J.F.; Fernandes, V.R.; Rangel, C.M.; Gales, L.; Pinto, A.M.F.R.. "Successive loadings of reactant in the hydrogen generation by hydrolysis of sodium borohydride in batch reactors". Journal of New Materials for Electrochemical Systems 12 2-3 (2009): 153-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449355037&partnerID=MN8TOARS.
  81. Gales, L.; Almeida, M.R.; Arsequell, G.; Valencia, G.; Saraiva, M.J.; Damas, A.M.. "Iodination of salicylic acid improves its binding to transthyretin". Biochimica et Biophysica Acta - Proteins and Proteomics 1784 3 (2008): 512-517. http://www.scopus.com/inward/record.url?eid=2-s2.0-43049162388&partnerID=MN8TOARS.
    10.1016/j.bbapap.2007.11.014
  82. Dethoup, T.; Manoch, L.; Kijjoa, A.; Pinto, M.; Gales, L.; Damas, A.M.; Silva, A.M.S.; Eaton, G.; Herz, W.. "Merodrimanes and other constituents from Talaromyces thailandiasis". Journal of Natural Products 70 7 (2007): 1200-1202. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548046228&partnerID=MN8TOARS.
    10.1021/np0680578
  83. Castanheiro, R.A.P.; Pinto, M.M.M.; Silva, A.M.S.; Cravo, S.M.M.; Gales, L.; Damas, A.M.; Nazareth, N.; Nascimento, M.S.J.; Eaton, G.. "Dihydroxyxanthones prenylated derivatives: Synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7". Bioorganic and Medicinal Chemistry 15 18 (2007): 6080-6088. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447630284&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.06.037
  84. Gales, L.; Saraiva, M.J.; Damas, A.M.. "Structural basis for the protective role of sulfite against transthyretin amyloid formation". Biochimica et Biophysica Acta - Proteins and Proteomics 1774 1 (2007): 59-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846117955&partnerID=MN8TOARS.
    10.1016/j.bbapap.2006.10.015
  85. Gomes, J.R.B.; Sousa, E.A.; Gonçalves, J.M.; Gales, L.; Damas, A.M.; Gomes, P.; Pandey, S.; Acree Jr., W.E.; Da Silva, M.D.M.C.R.. "Energetic and structural characterization of 2-R-3-methylquinoxaline-1,4- dioxides (R = benzoyl or tert-butoxycarbonyl): Experimental and computational studies". Journal of Physical Organic Chemistry 20 7 (2007): 491-498. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547326774&partnerID=MN8TOARS.
    10.1002/poc.1184
  86. Damas, A.M.; Almeida, M.R.; Gales, L.; Cardoso, I.; Saraiva, M.J.. "Pharmacologic approaches in the treatment of familial amyloidotic polyneuropathy,Utilização de fármacos na terapia da polineuropatia amiloidótica familiar". Sinapse 6 1 SUPPL. 1 (2006): 168-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745382011&partnerID=MN8TOARS.
  87. Ferreira-da-Silva, F.; Pereira, P.J.B.; Gales, L.; Roessle, M.; Svergun, D.I.; Moradas-Ferreira, P.; Damas, A.M.. "The crystal and solution structures of glyceraldehyde-3-phosphate dehydrogenase reveal different quaternary structures". Journal of Biological Chemistry 281 44 (2006): 33433-33440. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845918427&partnerID=MN8TOARS.
    10.1074/jbc.M605267200
  88. Gales, L.; Cortes, L.; Almeida, C.; Melo, C.V.; Costa, M.D.C.; Maciel, P.; Clarke, D.T.; Damas, A.M.; Macedo-Ribeiro, S.. "Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: Trapping early oligomers of non-expanded ataxin-3". Journal of Molecular Biology 353 3 (2005): 642-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244434741&partnerID=MN8TOARS.
    10.1016/j.jmb.2005.08.061
  89. Maia, F.; Almeida, M.D.R.; Gales, L.; Kijjoa, A.; Pinto, M.M.M.; Saraiva, M.J.; Damas, A.M.. "The binding of xanthone derivatives to transthyretin". Biochemical Pharmacology 70 12 (2005): 1861-1869. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744528447&partnerID=MN8TOARS.
    10.1016/j.bcp.2005.09.012
  90. Almeida, M.R.; Gales, L.; Damas, A.M.; Cardoso, I.; Saraiva, M.J.. "Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses". Current Drug Targets: CNS and Neurological Disorders 4 5 (2005): 587-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-26844484754&partnerID=MN8TOARS.
    10.2174/156800705774322076
  91. Gales, L.; Damas, A.M.. "Xanthones - A structural perspective". Current Medicinal Chemistry 12 21 (2005): 2499-2515. http://www.scopus.com/inward/record.url?eid=2-s2.0-26044453521&partnerID=MN8TOARS.
    10.2174/092986705774370727
  92. Vieira, L.M.M.; Kijjoa, A.; Wilirat, R.; Nascimento, M.S.J.; Gales, L.; Damas, A.M.; Silva, A.M.S.; Mondranondra, I.-O.; Herz, W.. "Erratum: Bioactive friedolanostanes and 11(10¿8)-abeolanostanes from the bark of Garcinia speciosa (Journal of Natural Products (2004) 67 (2043-2046))". Journal of Natural Products 68 6 (2005): 969-970. http://www.scopus.com/inward/record.url?eid=2-s2.0-22544436956&partnerID=MN8TOARS.
    10.1021/np058058k
  93. Gales, L.; Sousa, M.E.; Pinto, M.M.M.; Damas, A.M.. "3,4-Dihydroxy-9H-xanthen-9-one trihydrate". Acta Crystallographica Section E: Structure Reports Online 61 7 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-32244442730&partnerID=MN8TOARS.
    10.1107/S1600536805018994
  94. Gales, L.; Macedo-Ribeiro, S.; Arsequell, G.; Valencia, G.; Saraiva, M.J.; Damas, A.M.. "Human transthyretin in complex with iododiflunisal: Structural features associated with a potent amyloid inhibitor". Biochemical Journal 388 2 (2005): 615-621. http://www.scopus.com/inward/record.url?eid=2-s2.0-20544432502&partnerID=MN8TOARS.
    10.1042/BJ20042035
  95. Vieira, L.M.M.; Kijjoa, A.; Wilairat, R.; Nascimento, M.S.J.; Gales, L.; Damas, A.M.; Silva, A.M.S.; Mondranondra, I.-O.; Herz, W.. "Bioactive friedolanostanes and 11(10¿8)-abeolanostanes from the bark of Garcinia speciosa". Journal of Natural Products 67 12 (2004): 2043-2047. http://www.scopus.com/inward/record.url?eid=2-s2.0-11844273863&partnerID=MN8TOARS.
    10.1021/np049773h
  96. Vieira, L.M.M.; Kijjoa, A.; Silva, A.M.S.; Mondranondra, I.-O.; Kengthong, S.; Gales, L.; Damas, A.M.; Herz, W.. "Lanostanes and friedolanostanes from the bark of Garcinia speciosa". Phytochemistry 65 4 (2004): 393-398. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842306095&partnerID=MN8TOARS.
    10.1016/j.phytochem.2003.10.024
  97. Gales, L.; Mendes, A.; Costa, C.. "Recovery of acetone, ethyl acetate and ethanol by thermal pressure swing adsorption". Chemical Engineering Science 58 23-24 (2003): 5279-5289. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344287141&partnerID=MN8TOARS.
    10.1016/j.ces.2003.09.006
  98. Gales, L.; Cardoso, I.; Fayard, B.; Quintanilha, A.; Saraiva, M.J.; Damas, A.M.. "X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization". Journal of Biological Chemistry 278 13 (2003): 11654-11660. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038514252&partnerID=MN8TOARS.
    10.1074/jbc.M210798200
  99. Gales, L.; Cardoso, I.; Fayard, B.; Saraiva, M.J.; Damas, A.M.. "Sulphur K-edge XANES spectroscopy of transthyretin amyloid fibres". Spectroscopy 16 3-4 (2002): 281-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036965577&partnerID=MN8TOARS.
  100. Gales, L.; Mendes, A.; Costa, C.. "Removal of acetone, ethyl acetate and ethanol vapors from air using a hollow fiber PDMS membrane module". Journal of Membrane Science 197 1-2 (2002): 211-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037086772&partnerID=MN8TOARS.
    10.1016/S0376-7388(01)00628-7
  101. Filomena Costa, M.; Da Costa, M.R.G.; Marcelo Curto, M.J.; Magrinho, M.; Damas, A.M.; Gales, L.. "Synthesis of chiral (7R)-[¿6-5-(N,N-dimethylamino)-7-formyl-1,3-benzodioxole]chromium complex and its application in the synthesis of optically active cis-ß-lactams". Journal of Organometallic Chemistry 632 1-2 (2001): 27-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042871470&partnerID=MN8TOARS.
    10.1016/S0022-328X(01)00806-3
  102. Watanadilok, R.; Sonchaeng, P.; Kijjoa, A.; Damas, A.M.; Gales, L.; Silva, A.M.S.; Herz, W.. "Tetillapyrone and nortetillapyrone, two unusual hydroxypyran-2-ones from the marine sponge Tetilla japonica". Journal of Natural Products 64 8 (2001): 1056-1058. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034874827&partnerID=MN8TOARS.
    10.1021/np0100690
  103. Gales, L.; De Sousa, M.E.; Pinto, M.M.M.; Kijjoa, A.; Damas, A.M.. "Naturally occurring 1,2,8-trimethoxy-xanthone and biphenyl ether intermediates leading to 1,2-dimethoxy-xanthone". Acta Crystallographica Section C: Crystal Structure Communications 57 11 (2001): 1319-1323. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035498028&partnerID=MN8TOARS.
  104. Gales, L.; Mendes, A.; Costa, C.. "Hysteresis in the cyclic adsorption of acetone, ethanol and ethyl acetate on activated carbon". Carbon 38 7 (2000): 1083-1088. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033750083&partnerID=MN8TOARS.
    10.1016/S0008-6223(99)00224-9
  105. Mendes,A; Pinto, Luís; Costa, C. "Approximations for Intraparticle Mass Diffusion/Convection Models: A Review". Developments in Chemical Engineering & Mineral Processing 4 (1996): 105-125.
    Publicado
Artigo em revista (magazine)
  1. Damas, A.M.; Almeida, M.R.; Gales, L.; Cardoso, I.; Saraiva, M.J.. "Utilização de fármacos na terapia da polineuropatia amiloidótica familiar", Sinapse – Revista da Sociedade Portuguesa de Neurologia, 2006
Livro
  1. Leiro, V.; Moreno, P.M.; Sarmento, B.; Durão, J.; Gales, L.; Pêgo, A.P.; Barrias, C.C.. Design and preparation of biomimetic and bioinspired materials. 2016.
  2. Gales, L.; Aronson, J.K.. Thyroid hormones, iodine and iodides, and antithyroid drugs. 2014.
    10.1016/B978-0-444-62635-6.00041-3
  3. Gales, L.; Damas, A.M.. Three-dimensional structure of Xanthones. 2013.
Poster em conferência
  1. Gales, Luís. "Small-molecule chaperones of transthyretin/Abeta peptide interaction based on iododiflunisal scaffold as disease-modifying drug candidates for Alzheimer´s disease". Trabalho apresentado em The 14th International Conference on Alzheimer´s & Parkinson´s Diseases., 2019.
  2. Gales, Luís. "Alzheimer’s Aß 1-40 peptide degradation by the metalloprotease thermolysin: evidence of inhibition by a C-terminal Aß product In Workshop Strategies and tools for modulating pathologic protein self-assembly.". Trabalho apresentado em i3S anual meeting, 2019.
  3. Gales, Luís. "Mesoporous metal-organic frameworks as nucleating agentes in protein crystallography". Trabalho apresentado em XXIV Encontro Luso Galego de Química, 2018.
  4. Gales, Luís. "Alzheimer’s Aß1-40 peptide degradation by thermolysin: evidence of inhibition by a C-terminal Aß product". Trabalho apresentado em MCbiology PhD Symposium, 2018.
  5. Gales, Luís. "Structure-based drug design of transthyretin stabilizers”". Trabalho apresentado em From Protein Structure to Biological Function Through Interactomics: an integrated View (2nd Edition), 2018.
  6. Gales, Luís. "Synthesis of novel thiochromene quinazolines by copper-catalyzed tandem Ullmann type C – N coupling and dehydrative cyclization". Trabalho apresentado em 12º Encontro Nacional de Química Orgânica/5º Encontro Nacional de Química Terapêutica (12ºENQO/5ºENQT), 2018.
  7. Gales, Luís. "Role of the Wzc and Wzb interaction in the production of extracellular polymeric substances (EPS) by cyanobacteria". Trabalho apresentado em 5th i3S Annual Meeting, 2016.
  8. Gales, Luís. "Molinate bioremediation strategy using a microencapsulation approach". Trabalho apresentado em 6th Congress of European Microbiologists – FEMS 2015, 2015.
  9. Gales, Luís. "Diffusion of small gases inside dipeptide nanotubes. A non equilibrium molecular dynamics study.". Trabalho apresentado em XXIV Encontro Nacional da Sociedade Portuguesa de Química, 2015.
  10. Gales, Luís. "Development and validation of UV spectrophotometric method for determining the degradation of molinate by a free and microencapsulated enzyme.". Trabalho apresentado em 2nd International Conference on Chemical Engineering - ICCE 2014, 2014.
  11. Gales, Luís. "Bioactive Secondary Metabolites from Marine Sponge-Associated Fungi collected from the Gulf of Thailand.". Trabalho apresentado em MaNaPro 2013 XIV International Symposium on Marine Natural Products, 2013.
  12. Gales, Luís. "Modelling L-leucyl-L-serine (LS) dipeptide nanotubes. A molecular dynamics study". Trabalho apresentado em 11º Encontro Nacional de Química. Física, 2013.
  13. Gales, Luís. "Insights into the molecular mechanism of action of a new inhibitor of p53:MDM2 interaction". Trabalho apresentado em 6th Brazilian Symposium on Medicinal Chemistry – BrazMedChem2012, 2012.
  14. Gales, Luís. "Extracellular polymeric substances (EPS) from the unicellular cyanobacterium Cyanothece sp. CCY 0110: conditions influencing their production and polymer characterization". Trabalho apresentado em 14th International Symposium on Phototrophic Prokaryotes., 2012.
  15. Gales, Luís. "Bioactive secondary metabolites from the marine-sponge associated fungus Eurotium cristatum". Trabalho apresentado em 2nd International Symposium of Modern Medicine, Traditional Chinese Medicine and Uighur Medicine, 2012.
  16. Gales, Luís. "Extracellular polymeric substances (EPS) from Cyanothece sp. CCY 0110: conditions influencing their production and EPS characterization". Trabalho apresentado em MicroBiotec11, 2011.
  17. Gales, Luís. "Dipeptide crystals as excellent permselective materials". Trabalho apresentado em 24th European Conference on Biomaterials, 2011.
  18. Gales, Luís. "Extracellular polymeric substances (EPS) produced by cyanothece sp. CCY 0110: inducing factors, genes, and characteristics". Trabalho apresentado em 8th European Workshop on Molecular Biology of Cyanobacteria, 2011.
  19. Gales, Luís. "The Use of Ultrasounds in Protein Crystallization". Trabalho apresentado em British Association for Crystal Growth 2010 Conference, 2010.
  20. Gales, Luís. "Small Temperature Oscilations Greatly Affect Protein Crystallization". Trabalho apresentado em Advances in Protein Crystallography, 2010.
  21. Gales, Luís. "Dipeptide crystals as promising adsorbents and permselective organic zeolites". Trabalho apresentado em 5th International Zeolite Membrane Meeting, 2010.
  22. Gales, Luís. "Hydrogen storage in less Polar Organic Polymeric Solutions (lPOPS) under pressure". Trabalho apresentado em Hypothesis VIII, 7th Hydrogen Power Theoretical and Engineering Solutions International Symposium, 2009.
  23. Gales, Luís. "Structural and energetic studies of plycyclic compounds with sulphur hateroatoms". Trabalho apresentado em 1st National Meeting on Medicinal Chemistry, 2008.
  24. Gales, Luís. "Structural studies on an amyloidogenic transthyretin variant". Trabalho apresentado em 1st National Meeting on Medicinal Chemistry, 2008.
  25. Gales, Luís. "Iodination of salicylic acid improves its binding to transthyretin". Trabalho apresentado em 1st National Meeting on Medicinal Chemistry, 2008.
  26. Gales, Luís. "Crystallographic studies on transthyretin amyloidogenic properties". Trabalho apresentado em Symposium and meeting on “Systemic amyloidoses and relared issues, 2008.
  27. Gales, Luís. "The crystal structure of transthyretin in complex with 3,5-diiodosalicylic acid". Trabalho apresentado em 1st SMARTER Crystallography Workshop, 2007.
  28. Gales, Luís. "Packing interactions of the protein subunits in transthyretin amyloid fibres: the role of sulphur-containing amino acids". Trabalho apresentado em International School on Structural Characterization of Nanostructures, 2007.
  29. Gales, Luís. "The crystal structure of transthyretin in complex with 2-hydroxy-3,4-diiodo benzoic acid". Trabalho apresentado em XV Congresso Nacional de Bioquímica, Aveiro, 2006.
  30. Gales, Luís. "Structural and energetic studies of 2-Methyl-3-tert-Butyloxycarbonylquinoxaline-1,4-dioxide". Trabalho apresentado em VIth Ibero-American Congress of Biophysics, 2006.
  31. Gales, Luís. "Structural basis of the protective role of sulfite against transthyretin amyloid formation". Trabalho apresentado em VIth Ibero-American Congress of Biophysics, 2006.
  32. Gales, Luís. "Structural aspects of iododiflunisal binding to human transthyretin". Trabalho apresentado em VIth European Symposium of the Protein Society, 2005.
  33. Gales, Luís. "Crystal structure of human transthyretin in complex with iododiflunisal, a potent amyloid inhibitor". Trabalho apresentado em XIV Congresso Nacional de Bioquímica, 2004.
  34. Gales, Luís. "A new bromoalkoxyxanthone: synthesis, crystal structure and effect on human tumour cell lines". Trabalho apresentado em Transmediterranean Colloquium on Heterocyclic Chemistry, TRAMECH 2004, 2004.
  35. Gales, Luís. "Amyloid-like properties of non-expanded (14Q) human ataxin-3 oligomers.". Trabalho apresentado em FENS Abstr., vol.2, A020.18, 2004, 2004.
  36. Gales, Luís. "Sulfur oxidation in transthyretin is observed upon fibrillization: an x-ray absorption spectroscopy study". Trabalho apresentado em 21st European Crystallographic Meeting, 2003.
  37. Gales, Luís. "Lanostane-type tripernes from Garcinia speciosa". Trabalho apresentado em 5º Encontro Nacional de Química Orgânica, 2003.
  38. Gales, Luís. "Two Unusual Hydroxypyran-2-ones from the Marine Sponge Tetilla japonica". Trabalho apresentado em 3rd Euroconference on Marine Natural Products, 2002.
  39. Gales, Luís. "Determination of sulphur oxidation state in the soluble and fibrillar forms of thransthyretin by XANES spectroscopy". Trabalho apresentado em First International Conference on Biomedical Spectroscopy: From Molecules to Men, 2002.
  40. Gales, Luís. "Transthyretin Amyloid Fibres". Trabalho apresentado em 11th Annual Fibre Diffraction and Non-Crystalline Diffraction Workshop, 2002.
  41. Gales, Luís. "Laboratory classes on protein characterization – an integrated approach on biochemistry and biophysics". Trabalho apresentado em Congresso Nacional de Bioquímica, 2000.
  42. Gales, Luís. "Arquitectura de uma unidade de modelização no âmbito de uma biofísica laboratorial para estudantes de bioquímica". Trabalho apresentado em Congresso Nacional de Bioquímica, 2000.

Propriedade Intelectual

Patente
  1. US11458202B2 Cyanobacterium Extracellular Polymer, Compositions and Uses Thereof” (04.10.2022). Rita Mota, Sara Pereira,. 2022. "Cyanobacterium Extracellular Polymer, Compositions and Uses Thereof".
  2. Pinto, Luís; Rita Mota, Sara Pereira, José Leite, Paula Tamagnini. 2017. "Cyanobacterium Extracellular Polymer, Compositions and Uses Thereof". Portugal.
    Permitida
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/11/16 Tricyclic compounds derivatives as new potential neuroprotective agentes XXVI Encontro Galego-Portugués de Química
(Espanha)
2022/04/20 Synthesis and neuroprotection studies of new tricyclic compounds 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting,
(Portugal)
2021/05/19 Towards the discovery of small molecules with potential neuroprotective properties 7th Portuguese Young Chemists Meeting
(Portugal)
2021/04/13 Microrheology of a cyanobacterial extracellular polymer in human blood plasma 14th Annual European Rheology Conference
2020/12/17 Quantifying the linear viscoelasticity of human blood plasma. How elastic is it? 18th International Congress on Rheology
(Brasil)
2017/08/20 Production of Extracellular Polymeric Substances (EPS) in Synechocystis PCC 6803: the Role of WZC and WZB 10th European Workshop on the Molecular Biolgy of Cyanobacteria
(Roménia)
2017 Applications of cyanobacterial extracellular polymeric substances (EPS) 6th China-Europe Symposium on Biomaterials in Regenerative Medicine
2016/06/26 Gas Diffusion Inside L-Leucine-L-Serine Dipeptide Nanopores. A Non-Equilibrium Molecular Dynamics Study 13th International Conference on Diffusion in Solids and Liquids
(Áustria)
2013/07/13 Nanotube-forming hydrophobic dipeptides: structure, properties and applications 9th European-Biophysical-Societies-Association Congress
European-Biophysical-Societies-Association (Lisbon, Portugal)
2012/11/22 Peptide based functional materials Conferences of the Portuguese Biophysical Society
(Portugal)
2012/07/09 Peptide based materials: properties and potential applications Conferências do Programa Doutoral de Química,, FCUP
2010/07/05 Dipeptide crystals: potential applications in adsorption and membrane processes Ciência 2010
2009/09/13 Hydrogen gas storage in liquid organic media under pressure HYCELTEC 2009, 2nd Iberian Symposium on Hydrogen, Fuel Cells and Advanced Batteries
(Portugal)
2009/05/07 Peptide-based nanoporous crystals: synthesis and applications IBMC retreat
2009/04/01 NaOH free hydrolysis of sodium borohydride for hydrogen production HYPOTHESIS VIII, 7th Hydrogen Power Theoretical and Engineering Solutions International Symposium
(Portugal)
2008/07/01 Successive loadings of reactant in the hydrogen generation by hydrolysis of sodium borohydride in batch reactors HYCELTEC 2008, 1st Iberian Symposium on Hydrogen, Fuel Cells and Advanced Batteries
2008 TTR amyloidosis: structural insights and implications on therapeutical strategies 1st National Meeting on Medicinal Chemistry
(Portugal)
2006 Applications of sulfur X-ray absorption spectroscopy in Centre of Biological Engineering (invited by Artur Cavaco-Paulo)
2004 Molecular basis of protein aggregation in amyloid diseases 3rdPortuguese-Spanish Biophysics Congress
(Portugal)
2002 Sulphur K-edge XANES spectroscopy of transthyretin amyloid fibres XIII Congresso Nacional de Bioquímica
1998 Organic vapors separation from air using a combined membrane and adsorption technology – a simulation study 7th International Chemical Engineering Conference
(Portugal)
1997 Study of the hysteresis on the adsorption of VOCs on activated carbon in 23rd Biennial Conference on Carbon
(Estados Unidos)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019/10/01 - Atual EPS-MOF two step method for recognition of plasma proteins in disease relevant conformation: application to transthyretin amyloidosis
Orientador
 Biotecnologia Molecular e Celular aplicada às Ciências da Saúde (BiotechHealth) (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/02/01 - 2022/07/31 Materiais cristalinos (MOFs) para construção de sensores para potenciais biomarcadores de amiloidoses
Orientador
 Licenciatura Bioquímica (Licenciatura/Bacharelato)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01/01 - 2022/06/01 Cross-linked Thermolysin Crystals as Biosensors for Amyloid-ß Peptide
Orientador
 Programa de Mobilidade: Programa Erasmus+ Estágios (Licenciatura/Bacharelato)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2022/03/18 Unveiling the structural basis for Alzheimer´s amyloid-ß peptide aggregation using new crystallization approaches
Orientador
 Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2021/12/02 Unveiling biosynthetic pathways for the production of extracellular polymeric substances (EPS) in cyanobacteria and possible applications of the polymers
Coorientador
 Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2018 Release and celular uptake of anticancer drugs encapsulated in apoferritin
Orientador
 Mestrado Integrado de Bioengenharia (Mestrado)
2010 - 2016/07/08 Peptide self-assembled materials for gas transport
Orientador de Joana Durão
 Engenharia Biomédica (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2009 - 2016/06/09 Experimental results and theoretical investigation of adsorption of gases in crystalline hydrophobic dipeptides
Orientador de Rui Afonso
 Engenharia Química e Biológica (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2012 - 2013 Synthesis of peptide-based porous materials
Coorientador
 Ciências de Engenharia, orientação em Engenharia Química (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2012 - 2013 Characterization of the novel molinate hydrolase for bioremediation processes
Orientador
 Bioengenharia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 - 2013 Containers to improve the solubility and bioavailability of poorly water-soluble pharmaceuticals
Orientador
 Bioengenharia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 - 2013 Nitric oxide delivering biomolecular assemblies for biomedical applications
Orientador
 Bioengenharia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2012 RGD-based metal organic frameworks for selective delivery of therapeutics to tumour vasculature
Orientador
 Bioengenharia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018/03/23 - 2018/03/26 Workshop – À descoberta do mundo dos cristais - da biologia molecular à nanotecnologia, in XI ENEBIOQ – Encontro Nacional de Estudantes de Bioquímica, Porto, Portugal (2018/03/25 - 2018/03/25)
Oficina (workshop) (Coorganizador)
2015/03/20 - 2015/03/22 Workshop – Protein Crystallography, in III Biomedical Congress 20-22 March ICBAS, Porto, Portugal (2015/03/21 - 2015/03/21)
Oficina (workshop) (Coorganizador)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2018/06/23 - 2018/06/28 Advanced Course in Marine Natural Products: Discovery and Structure Elucidation, in CIIMAR, 23-28 Jun 2018.
Encontro

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/02/19 Synthesis and application of ROS generators nanomaterials for antioxidante biomolecules screening and for assessing their potential in cell protection during phototherapy
Arguente
 Gabriel Silva Graça (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/12/18 Deteção de biomarcadores aniónicos para discriminação de células cancerígenas
Arguente
 Eduarda Manuela Pinho Andrade (Mestrado)
Universidade de Aveiro, Portugal
2023/11/28 Discovery of Aberrant Protein Self-Assembly Fingerprints in Molecular Hallmarks of Aging
Arguente
 Tiago André Carneiro Major (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2023/03/14 Biochemical and structural sharacterization of desulfurization enzymes
Arguente
 Ana Rita Coelho Reis da Encarnação (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2022/11/30 Detection of biomarkers associated to cancer
Arguente
 Fábio Alexandre Gomes Ramalho (Mestrado)
Universidade de Aveiro, Portugal
2022/11/29 In vivo and in vitro characterization of a bacterial transporter
Arguente
 Inês Rosa Figueiredo da Costa (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/06/02 Modulation of mechanisms driving TTR amyloidogenesis: from tetramer destabilization to TTR proteolysis
Vogal
 Carla Filipa Pereira Bezerra (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/03/18 Biophysical analysis of Alzheimer’s amyloid-ß peptide assembly and clearance pathways
Orientador
 José Pedro Leite (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/11/24 Rolling Circle Amplification (RCA) on-ship towards covid-19 molecular diagnostics
Arguente
 João Carlos Varela (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/07/16 Epithelial Organization at Mitotic Exit
Vogal
 Mariana Costa Osswald (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/06/09 Regulation of the KtrAB cation channel
Vogal
 Celso Moura Teixeira Duarte (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/07/20 Structure-function analysis of a carbohydrate esterase family 5 enzyme from Thielavia terrestris
Arguente
 Leonor Vieira Carneiro (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/14 Bioactive Secondary Metabolites from Marine-Derived Fungi Collected from Thai Waters
Vogal
 Decha Kumla (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/12/19 Molecular sensors of codon ambiguity in Candida albicans signaling pathways
Vogal
 Joana Fraga (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/21 Study of bioactive secondary metabolites from the marine sponges and marine sponge – associated fungi.
Vogal
 Chadaporn Prompanya (Doutoramento)
2018/06/29 Biochemical and structural characterization of novel mycobacterial drug targets
Vogal
 Tatiana Barros Reis Cereija (Doutoramento)
2018/06/07 Determinação de impurezas metálicas e não-metálicas em medicamentos e suplementos alimentares por fluorescência de raios X dispersiva em comprimento de onda (WDXRF) e avaliação dos potenciais riscos na saúde
Vogal
 • Maria Alexandra Gil Figueiredo (Doutoramento)
2017/09/29 Pharmacological chaperones to prevent transthyretin amyloidosis
Arguente principal
 Francisca Garcia de Carvalho Pinheiro (Mestrado)
2017/03/08 Cristalização avançada de moléculas biologicamente relevantes
Vogal
 Cecília Fernanda de Sá Ferreira Rodrigues (Doutoramento)
2016/12/22 Synthesis and characterization of small pore membranes and their application to the separation of hydrogen containing mixtures.
Vogal
 Simão Pedro Pereira Cardoso (Doutoramento)
2016/07/08 Peptide self-assembled materials for gas transport
Orientador
 Joana Durão (Doutoramento)
2016/06/09 Experimental results and theoretical investigation of adsorption of gases in crystalline hydrophobic dipeptides
Orientador
 Rui Vieira Afonso (Doutoramento)
2015/12/18 Structural and biochemical characterization of the interaction of calmodulin with the EAG1 potassium channel cytoplasmic regions.
Vogal
 Maria João Marques de Carvalho (Doutoramento)
2014/07/07 Assessment of the Binding Properties of KtrA to ATP and ADP
Arguente principal
 João Miguel Antunes Santos (Mestrado)
2014/06/17 Isolation, characterization and biological activity evaluation of bioactive compounds from marine sponge-associated fungi.
Vogal
 Nelson Gonçalo Mortágua Gomes (Doutoramento)
2013/12/20 Functional and structural studies of two enzymes: membrane bound kinase and Z-DNA/Z-RNA-binding protein
Arguente principal
 Ana Lúcia Rebelo do Rosário (Doutoramento)
2013/07/27 Structure-function analysis of multi-copper oxidases.
Arguente principal
 Catarina Isabel Simões Pires da Silva (Doutoramento)
2011/12/13 Modulation of transthyretin amyloidogenesis by small ligands: in vitro and in vivo studies
Vogal
 Nelson Carlos Gomes Ferreira (Doutoramento)
2010/09/14 Ataxin-3 aggregation and its impact on membrane destabilization
Arguente principal
 João Ribas (Mestrado)
2009/12/16 Structural Analysis of PAS Domains from EAG Potassium Channels
Arguente principal
 Ricardo Adaixo (Mestrado)
2007/12/11 Role of Transthyretin in Amyloid beta toxicity.
Arguente principal
 Ana Rita Costa (Mestrado)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - 2020 Phytochemistry (0031-9422) Elsevier
2019 - 2019 Theranostics (1838-7640) Ivyspring International Publisher
2018 - 2018 Crystals (2073-4352) MDPI AG
2018 - 2018 Dyes and Pigments (0143-7208) Elsevier
2018 - 2018 International Journal of Nanomedicine (1178-2013) Dove Medical Press
2018 - 2018 Marine Drugs (1660-3397) MDPI AG
2018 - 2018 Nanoscale (2040-3372) The Royal Society of Chemistry
2018 - 2018 AIMS Biophysics (2377-9098) American Institute of Mathematical Sciences
2017 - 2018 Acta Biomaterialia (1742-7061) Elsevier
2015 - 2017 Molecules (1420-3049) MDPI AG
2016 - 2016 Adsorption Science & Technology (2048-4038) SAGE Publications
2016 - 2016 Journal of Food Biochemistry (1745-4514) Wiley (Blackwell Publishing)
2016 - 2016 RSC Advances (2046-2069) The Royal Society of Chemistry
2015 - 2015 Acta Crystallographica Section C Crystal Structure Communications (1600-5759) International Union of Crystallography
2015 - 2015 Arabian Journal of Chemistry (1878-5352) Elsevier
2015 - 2015 International Journal of Hydrogen Energy (0360-3199) Elsevier
2015 - 2015 Journal of Materials Chemistry B (2050-7518) The Royal Society of Chemistry
2015 - 2015 PLoS ONE (1932-6203) Public Library of Science
2011 - 2015 Biochemical Pharmacology (0006-2952) Elsevier
2012 - 2014 CrystEngComm (1466-8033) The Royal Society of Chemistry
2013 - 2013 Materials
2011 - 2011 Powder Technology (0032-5910) Elsevier

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2019 - 2019 National Science Centre of Poland. Funding Schemes OPUS: General proposals. Panel ST4 - Physical and analytical chemical sciences. Project reviewer
Avaliador
2011 - 2011 •Programa de Iniciação à Investigação da U.Porto – Concurso 2011 PROJECTOS PLURIDISCIPLINARES

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018 - Atual Fundamentals of Biophysics and Chemistry Medicina (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - Atual Structure and Function of Proteins (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - Atual Nanotechnology for health Bioengenharia (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006 - Atual Biophysics Bioengenharia (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1998 - Atual Biophysics/ Biophysics and Biochemistry Ciências do Meio Aquático (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1998 - Atual Biophysics Bioquímica (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1998 - Atual Biophysics Ciências Veterinárias (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1998 - 2018 Biophysics Medicina (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2003 - 2010 Protein Crystallography GABBA Doctoral Program, University of Porto (Doktor (PhD)) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023/05/25 - Atual Sub-director of the Molecular Biology Department (ICBAS)
Presidente / Vice-presidente
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/03/25 - Atual Representante ICBAS na Comissão de elaboração do programa doutoral em Física Médica da U.Porto (sede administrativa FCUP) ICBAS representative on the Commission for the preparation of the doctoral program in Medical Physics at the U.Porto (administrative headquarters FCUP)
2011/05/26 - 2013/05/26 Member of the Teaching Standards Committee
2010/02/23 - 2012/02/23 Member of the Representatives Council
Membro
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006 - 2010 Assistant Director of Master in Bioengineering
Membro

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023/05/01 - Atual Contratação de Professor Auxiliar para a área disciplinar de Biofísica Médica da Universidade de Coimbra (Edital n.º 667/2023). Maio de 2023
2018/07 - 2018/07 Integrou o júri no momento concursal de seleção internacional para a contratação pelo IBMC de 1 doutorado (a) ao abrigo do artigo 23.º do decreto-lei n.º 57/2016, de 29 de agosto, alterado pela lei nº 57/2017, de 19 de julho (posição 30). Julho 2018
Distinções

Prémio

2021 Laboratório da Sociedade Portuguesa de Medicina da Reprodução - Implications of treatment of COVID-19 infection for human sperm
Sociedade Portuguesa de Medicina da Reprodução, Portugal