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Jorge H. Leitão is Associate Professor with Habilitation at the Department of Bioengineering, Instituto Superior Técnico (University of Lisbon), Portugal, since 2015. His current research interests are focused on post-transcription regulation of bacterial gene expression and the roles played by small non-coding regulatory RNAs and RNA chaperones on the biology and pathogenesis of bacteria of the Burkholderia cepacia complex . Other research interests include exopolysacharide biosynthesis by Gram(-) bacteria, resistance to antimicrobials and development of novel antimicrobials, and the molecular characterization of microbial populations of ecological, industrial, and health interest.
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Identificação

Identificação pessoal

Nome completo
Jorge Humberto Gomes Leitão

Nomes de citação

  • Leitão, Jorge

Identificadores de autor

Ciência ID
4116-A4E6-8814
ORCID iD
0000-0001-8850-274X

Endereços de correio eletrónico

  • jorgeleitao@tecnico.ulisboa.pt (Profissional)

Telefones

Telefone
  • 218417688 (Profissional)

Moradas

  • Instituto Superior Técnico, Departamento de Bioengenharia, Torre Sul, piso 6. Av. Rovisco Pais, 1049-001, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Microbiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2015/06/16
Concluído
 Biotecnologia (Título de Agregado)
Especialização em Microbiologia Molecular
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Aprovado por unanimidade
1992/02/01 - 2006/01/30
Concluído
 Biotecnologia e Biociências (Doutoramento)
Especialização em Ciências Biológicas/Microbiologia Molecular
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Distinção e Louvor
1989/10/01 - 1992/02/10
Concluído
 Biotecnologia (Engenharia Bioquímica) (Mestrado)
Especialização em Microbiologia
Universidade de Lisboa Instituto Superior Técnico, Portugal
1984/10/01 - 1989/09/13
Concluído
 Engenharia Química (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
 14
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/01 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal
Projetos

Projeto

Designação Financiadores
2023/02 - 2024/07 Are non-coding RNAs contained in Burkholderia cepacia complex extracellular vesicles used to manipulate the host's immune response?
2022.07091.PTDC
IBB - Instituto de Bioengenharia e Biociências, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/01/01 - 2019/12/31 B-Safecoat – Desenvolvimento de novas tintas com propriedades auto-desinfetantes
POCI-01-0247-FEDER-017875
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal
Concluído
2016/05/01 - 2019/10/31 CNCVir - The coding and noncoding virulome of Burkholderia cenocepacia
PTDC/BIA-MIC/1615/2014
Investigador responsável
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2013/04/01 - 2015/04/01 Exploitation of immunogenic proteins of the Burkholderia cepacia complex to design new diagnostic and therapeutic strategies
PTDC/BBB-BIO/1958/2012
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012/01/01 - 2014/12/31 RNomics-Bcc: RNomics studies to identify small non-coding RNAs of Burkholderia cepacia complex involved in host-pathogen interactions
PTDC/BIA-MIC/119091/2010
Investigador responsável
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
2010/01/01 - 2013/06/30 Exploiting the type II phosphomannose isomerase BceAJ as a new target for the development of new antimicrobials and for biotechnological applications
PTDC/EBB-BIO/098352/2008
Investigador responsável
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009/04 - 2012/04 Assinatura ADHRES: perfil de expressão de genes envolvidos na adesão (ADH) e na resistência a antibióticos (RES) em biofilmes bacterianos
ERA-PTG/SAU/0001/2008
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal
Concluído
2010/01/01 - 2011/12/31 Regulation of Burkholderia cepacia complex gene expression under low oxygen tensions
A-09/10
Investigador responsável
Concluído
2008/01/01 - 2011/09/30 Optimization and Control of Intermittent UASB Reactors and Microbial Population Dynamics
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/65025/PT
Investigador
Concluído
2007/12/01 - 2010/12/30 Regulation of exopolysaccharide biosynthesis and virulence of Burkholderia cepacia by protein-tyrosine phosphorylation
info:eu-repo/grantAgreement/FCT/3599-PPCDT/65210/PT
Investigador
Fundação para a Ciência e a Tecnologia
2007/10/27 - 2010/10/26 Acute versus persistent infection by Burkholderia cepacia complex bacteria in cystic fibrosis patients: underlying mechanisms, in particular the role of exopolysaccharide biosynthesis
info:eu-repo/grantAgreement/FCT/3599-PPCDT/69591/PT
Investigador
Fundação para a Ciência e a Tecnologia
2007/07/01 - 2010/10/01 Pseudomonas aeruginosa and Burkholderia cepacia infections in cystic fibrosis
PSAU/P/SAU/59/96
Investigador
Concluído
2006/01/01 - 2007/12/31 Virulence of Burkholderia cepacia complex strains from cystic fibrosis patients assessed in the gp91(phox-/-) mouse model
GRICES/DAAD
Investigador responsável
Universidade de Lisboa Instituto Superior Técnico, Portugal
2003/06/01 - 2006/07/01 Studies to produce an exopolysaccharide-vaccine to protect cystic fibrosis patients against Burkholderia cepacia infections
info:eu-repo/grantAgreement/FCT/POCI/38273/PT
Investigador responsável
Fundação para a Ciência e a Tecnologia
1996/05/01 - 1999/04/30 Genetic and environmental manipulation of bacterial exopolysaccharide biosynthetic pathways
2/2.1/BIO/1125/95
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal
Concluído
Produções

Publicações

Artigo em conferência
  1. Sousa, S.A.; Ramos, C.G.; Feliciano, J.; Leitão, J.H.. "Identification and exploitation of Burkholderia cepacia complex virulence factors as potential antimicrobial targets". 2011.
    10.1109/ENBENG.2011.6026036
  2. Ramos, C.G.; Sousa, S.A.; Grilo, A.M.; Da Costa, P.J.P.; Feliciano, J.R.; Leitão, J.H.. "A RNomics-based strategy identifies regulatory small RNAs in Burkholderia cepacia complex". 2011.
    10.1109/ENBENG.2011.6026035
Artigo em revista
  1. Gonçalo R. Matos; Joana R. Feliciano; Jorge H. Leitão. "Non-coding regulatory sRNAs from bacteria of the Burkholderia cepacia complex". Applied Microbiology and Biotechnology (2024): https://doi.org/10.1007/s00253-024-13121-6.
    10.1007/s00253-024-13121-6
  2. António Seixas; Carolina Silva; Joana Monteiro Marques; Patrícia Mateus; Manuel J. Rodríguez-Ortega; Joana Feliciano; Jorge H. Leitão; Sousa SA. "Surface-Exposed Protein Moieties of Burkholderia cenocepacia J2315 in Microaerophilic and Aerobic Conditions". Vaccines (2024): https://www.mdpi.com/2076-393X/12/4/398.
    10.3390/vaccines12040398
  3. António M. M. Seixas; Sara C. Gomes; Carolina Silva; Leonilde M. Moreira; Jorge H. Leitão; Sílvia A. Sousa. "A Polyclonal Antibody against a Burkholderia cenocepacia OmpA-like Protein Strongly Impairs Pseudomonas aeruginosa and B. multivorans Virulence". Vaccines (2024): https://doi.org/10.3390/vaccines12020207.
    10.3390/vaccines12020207
  4. Jorge H. Leitão; Joana R. Feliciano; Nitin Amdare. "Advances in Human Pathogen Control—A 21st Century Challenge". Vaccines (2023): https://doi.org/10.3390/vaccines11091449.
    10.3390/vaccines11091449
  5. Tiago Pita; Joana R. Feliciano; Jorge H. Leitão. "Identification of Burkholderia cenocepacia non-coding RNAs expressed during Caenorhabditis elegans infection". Applied Microbiology and Biotechnology (2023): https://doi.org/10.1007/s00253-023-12530-3.
    10.1007/s00253-023-12530-3
  6. Rui N. L. Carvalho; Luisa L. Monteiro; Silvia A. Sousa; Sudarsu V. Ramanaiah; Jorge H. Leitão; Cristina M. Cordas; Luis P. Fonseca. "Design and Optimization of Microbial Fuel Cells and Evaluation of a New Air-Breathing Cathode Based on Carbon Felt Modified with a Hydrogel—Ion Jelly®". Energies (2023): https://doi.org/10.3390/en16104238.
    10.3390/en16104238
  7. Andreia Sousa; Joana F. Santos; Francisco Silva; Sílvia A. Sousa; Jorge H. Leitão; António P. Matos; Teresa Pinheiro; et al. "Antitumoral and Antimicrobial Activities of Block Copolymer Micelles Containing Gold Bisdithiolate Complexes". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15020564.
    10.3390/pharmaceutics15020564
  8. Tomasz Bogiel; Dagmara Depka; Stanislaw Kruszewski; Adrianna Rutkowska; Piotr Kanarek; Mateusz Rzepka; Jorge H. Leitão; Aleksander Deptula; Eugenia Gospodarek-Komkowska. "Comparison of Virulence-Factor-Encoding Genes and Genotype Distribution amongst Clinical Pseudomonas aeruginosa Strains". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24021269.
    10.3390/ijms24021269
  9. Paulo J. G. Bettencourt; Jorge H. Leitão. "Microbial Antigen Identification and Vaccine Delivery Systems". Vaccines (2022): https://doi.org/10.3390/vaccines10122053.
    10.3390/vaccines10122053
  10. António Seixas; Sousa SA; Jorge H. Leitão. "Antibody-Based Immunotherapies as a Tool for Tackling Multidrug-Resistant Bacterial Infections". Vaccines (2022): https://www.mdpi.com/2076-393X/10/11/1789.
    10.3390/vaccines10111789
  11. Joana P. Costa; Teresa Pinheiro; Maria S. Martins; M. Fernanda N. N. Carvalho; Joana R. Feliciano; Jorge H. Leitão; Rafaela A. L. Silva; et al. "Tuning the Biological Activity of Camphorimine Complexes through Metal Selection". Antibiotics (2022): https://doi.org/10.3390/antibiotics11081010.
    10.3390/antibiotics11081010
  12. Yann Le Gal; Agathe Filatre-Furcate; Dominique Lorcy; Olivier Jeannin; Thierry ROISNEL; Vincent Dorcet; Diana Fontinha; et al. "Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/13/7146.
    10.3390/ijms23137146
  13. "Estrogens in wastewaters: Can different operating conditions improve their removal in anaerobic conditions?". Water and Environment Journal (2022): http://dx.doi.org/10.1111/wej.12773.
    10.1111/wej.12773
  14. "Bioelectricity generation using long-term operated biocathode: RFLP based microbial diversity analysis". Biotechnology Reports 32 (2021): e00693-e00693. http://dx.doi.org/10.1016/j.btre.2021.e00693.
    10.1016/j.btre.2021.e00693
  15. António M. M. Seixas; Sílvia A. Sousa; Joana R. Feliciano; Sara C. Gomes; Mirela R. Ferreira; Leonilde M. Moreira; Jorge H. Leitão. "A Polyclonal Antibody Raised against the Burkholderia cenocepacia OmpA-like Protein BCAL2645 Impairs the Bacterium Adhesion and Invasion of Human Epithelial Cells In Vitro". Biomedicines (2021): https://doi.org/10.3390/biomedicines9121788.
    10.3390/biomedicines9121788
  16. Joana P. Costa; Sílvia A. Sousa; Catarina Soeiro; Jorge H. Leitão; Adelino M. Galvão; Fernanda Marques; M. Fernanda N. N. Carvalho. "Synthesis and Characterization of Camphorimine Au(I) Complexes with a Remarkably High Antibacterial Activity towards B. contaminans and P. aeruginosa". Antibiotics 10 10 (2021): 1272-1272. https://doi.org/10.3390/antibiotics10101272.
    10.3390/antibiotics10101272
  17. Sousa SA; Joana Feliciano; Tiago Pita; Catarina Soeiro; Beatriz L. Mendes; Luis G. Alves; Jorge H. Leitão. "Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials". Antibiotics (2021): https://www.mdpi.com/2079-6382/10/8/942.
    10.3390/antibiotics10080942
  18. Sílvia A. Sousa; António M. M. Seixas; Joana M. M. Marques; Jorge H. Leitão. "Immunization and Immunotherapy Approaches against Pseudomonas aeruginosa and Burkholderia cepacia Complex Infections". Vaccines 9 6 (2021): 670-670. https://doi.org/10.3390/vaccines9060670.
    10.3390/vaccines9060670
  19. Mihaela Cudalbeanu; David Peitinho; Francisco Silva; Rosa Marques; Teresa Pinheiro; Ana C. Ferreira; Fernanda Marques; et al. "Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties". Nanomaterials (2021): https://www.mdpi.com/2079-4991/11/6/1562.
    10.3390/nano11061562
  20. Louros, Vitória L.; Lima, Diana L.D.; Leitão, Jorge H.; Esteves, Valdemar I.; Nadais, Helena G.A.. "Impact of UASB reactors operation mode on the removal of estrone and 17a-ethinylestradiol from wastewaters". Science of The Total Environment 764 (2021): 144291. http://dx.doi.org/10.1016/j.scitotenv.2020.144291.
    Acesso aberto • Publicado • 10.1016/j.scitotenv.2020.144291
  21. Joana P. Costa; Sílvia A. Sousa; Adelino M. Galvão; J. Miguel Mata; Jorge H. Leitão; M. Fernanda N. N. Carvalho. "Key Parameters on the Antibacterial Activity of Silver Camphor Complexes". Antibiotics (2021): https://doi.org/10.3390/antibiotics10020135.
    10.3390/antibiotics10020135
  22. Tiago Pita; Joana R. Feliciano; Jorge H. Leitão. "Extracellular RNAs in Bacterial Infections: From Emerging Key Players on Host-Pathogen Interactions to Exploitable Biomarkers and Therapeutic Targets". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21249634.
    10.3390/ijms21249634
  23. Jorge H. Leitão; Manuel J. Rodríguez-Ortega. "Omics and Bioinformatics Approaches to Identify Novel Antigens for Vaccine Investigation and Development". Vaccines 8 4 (2020): 653-653. https://doi.org/10.3390/vaccines8040653.
    10.3390/vaccines8040653
  24. Sílvia A. Sousa; António M.M. Seixas; Manoj Mandal; Manuel J. Rodríguez-Ortega; Jorge H. Leitão. "Characterization of the Burkholderia cenocepacia J2315 Surface-Exposed Immunoproteome". Vaccines (2020): https://doi.org/10.3390/vaccines8030509.
    10.3390/vaccines8030509
  25. Jorge H. Leitão. "Listeria monocytogenes as a Vector for Cancer Immunotherapy". Vaccines 8 3 (2020): 439-439. https://doi.org/10.3390/vaccines8030439.
    10.3390/vaccines8030439
  26. Leitão, Jorge H.. "New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action". Antibiotics 9 8 (2020): 471. http://dx.doi.org/10.3390/antibiotics9080471.
    Acesso aberto • 10.3390/antibiotics9080471
  27. Jorge H. Leitão. "Microbial Virulence Factors". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21155320.
    10.3390/ijms21155320
  28. Feliciano, Joana R.; Seixas, António M. M.; Pita, Tiago; Leitão, Jorge H.. "Comparative Genomics and Evolutionary Analysis of RNA-Binding Proteins of Burkholderia cenocepacia J2315 and Other Members of the B. cepacia Complex". Genes 11 2 (2020): 231. http://dx.doi.org/10.3390/genes11020231.
    10.3390/genes11020231
  29. Sílvia A. Sousa; Pedro Soares-Castro; António M.M. Seixas; Joana R. Feliciano; Bernardo Balugas; Celeste Barreto; Luísa Pereira; Pedro M. Santos; Jorge H. Leitão. "New insights into the immunoproteome of B. cenocepacia J2315 using serum samples from cystic fibrosis patients". New Biotechnology 54 (2020): 62-70. https://doi.org/10.1016/j.nbt.2019.08.006.
    10.1016/j.nbt.2019.08.006
  30. Sousa, Sílvia A.; Leitão, Jorge H.; Silva, Rafaela A.L.; Belo, Dulce; Santos, Isabel C.; Guerreiro, Joana F.; Martins, Marta; et al. "On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities". Journal of Inorganic Biochemistry 202 (2020): 110904. http://dx.doi.org/10.1016/j.jinorgbio.2019.110904.
    10.1016/j.jinorgbio.2019.110904
  31. Fontinha, Diana; Sousa, Sílvia A.; Morais, Tânia S.; Prudêncio, Miguel; Leitão, Jorge H.; Le Gal, Yann; Lorcy, Dominique; et al. "Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents". Metallomics 12 6 (2020): 974-987. http://dx.doi.org/10.1039/d0mt00064g.
    10.1039/d0mt00064g
  32. Mihaela Cudalbeanu; Bianca Furdui; Geta Cârâc; Vasilica Barbu; Alina Viorica Iancu; Fernanda Marques; Jorge Humberto Leitão; Sílvia Andreia Sousa; Rodica Mihaela Dinica. "Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts". Antibiotics 9 1 (2019): 7-7. https://doi.org/10.3390/antibiotics9010007.
    10.3390/antibiotics9010007
  33. Luis G. Alves; João F. Portel; Sílvia A. Sousa; Olga Ferreira; Stephanie Almada; Elisabete R. Silva; Ana M. Martins; Jorge H. Leitão. "Investigations into the Structure/Antibacterial Activity Relationships of Cyclam and Cyclen Derivatives". Antibiotics 8 4 (2019): 224-224. https://doi.org/10.3390/antibiotics8040224.
    10.3390/antibiotics8040224
  34. Leitão, Jorge. "Ag(I) camphor complexes: antimicrobial activity by design". Journal of Inorganic Biochemistry (2019): http://dx.doi.org/10.1016/j.jinorgbio.2019.110791.
    10.1016/j.jinorgbio.2019.110791
  35. Joana P. Costa; M. Joana F. Pinheiro; Sílvia A. Sousa; Ana M. Botelho do Rego; Fernanda Marques; M. Conceição Oliveira; Jorge H. Leitão; Nuno P. Mira; M. Fernanda N. N. Carvalho. "Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains". Antibiotics (2019): https://doi.org/10.3390/antibiotics8030144.
    10.3390/antibiotics8030144
  36. Louros, Vitória L.; Lima, Diana L.D.; Leitão, Jorge H.; Esteves, Valdemar I.; Nadais, Helena G.. "Determination of estrone and 17a-ethinylestradiol in digested sludge by ultrasonic liquid extraction and high-performance liquid chromatography with fluorescence detection". Journal of Separation Science (2019): http://dx.doi.org/10.1002/jssc.201801114.
    10.1002/jssc.201801114
  37. Leitão, Jorge. "Differential effects of Th17 cytokines during the response of neutrophils to Burkholderia cenocepacia outer membrane protein A". Central European Journal of Immunology (2019): http://dx.doi.org/10.5114/ceji.2019.92800.
    10.5114/ceji.2019.92800
  38. Tiago Pita; Joana R. Feliciano; Jorge H. Leitão. "Small Noncoding Regulatory RNAs from Pseudomonas aeruginosa and Burkholderia cepacia Complex". International Journal of Molecular Sciences (2018): http://www.mdpi.com/1422-0067/19/12/3759.
    10.3390/ijms19123759
  39. Leitão, Jorge. "Silver Camphor Imine Complexes: Novel Antibacterial Compounds from Old Medicines". Antibiotics (2018): http://www.mdpi.com/2079-6382/7/3/65.
    10.3390/antibiotics7030065
  40. Leitão, Jorge. "Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Burkholderia cepacia Complex". Vaccines (2018): http://www.mdpi.com/2076-393X/6/2/34.
    10.3390/vaccines6020034
  41. Martina, Pablo; Leguizamon, Mariana; Prieto, Claudia I.; Sousa, Silvia A.; Montanaro, Patricia; Draghi, Walter O.; Stämmler, Maren; et al. "Burkholderia puraquae sp. nov., a novel species of the Burkholderia cepacia complex isolated from hospital settings and agricultural soils". International Journal of Systematic and Evolutionary Microbiology 68 1 (2018): 14-20. http://dx.doi.org/10.1099/ijsem.0.002293.
    10.1099/ijsem.0.002293
  42. Ana S. Moreira; Dalila Mil-Homens; Sílvia A. Sousa; Carla P. Coutinho; Ana Pinto-de-Oliveira; Christian G. Ramos; Sandra C. dos Santos; et al. "Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection". Virulence (2017): 1-15. https://doi.org/10.1080/21505594.2016.1237334.
    10.1080/21505594.2016.1237334
  43. João M. S. Cardoso; Andrew C. Singer; Soraia I. Guerreiro; Andreia Lourenço; Marta M. Alves; M. Fátima Montemor; Nuno P. Mira; Jorge H. Leitão; M. Fernanda N. N. Carvalho. "Ag(I) camphorimine complexes with antimicrobial activity towards clinically important bacteria and species of the Candida genus". PLOS ONE (2017):
    10.1371/journal.pone.0177355
  44. Luis G. Alves; Pedro F. Pinheiro; Joana R. Feliciano; Diana P. Dâmaso; Jorge H. Leitão; Ana M. Martins. "Synthesis, antimicrobial activity and toxicity to nematodes of cyclam derivatives". International Journal of Antimicrobial Agents (2017):
    10.1016/j.ijantimicag.2017.03.002
  45. Sílvia Sousa; Joana Feliciano; Tiago Pita; Soraia Guerreiro; Jorge Leitão. "Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review". Genes 8 12 (2017): 43-43. https://doi.org/10.3390/genes8010043.
    10.3390/genes8010043
  46. Sousa SA; Morad M; Feliciano JR; Pita T; Nady S; El-Hennamy RE; Abdel-Rahman M; et al. "The Burkholderia cenocepacia OmpA-like protein BCAL2958: identification, characterization, and detection of anti-BCAL2958 antibodies in serum from B. cepacia complex-infected Cystic Fibrosis patients.". (2016): http://europepmc.org/abstract/med/27325348.
    10.1186/s13568-016-0212-1
  47. Cardoso JM; Galvão AM; Guerreiro SI; Leitão JH; Suarez AC; Carvalho MF. "Antibacterial activity of silver camphorimine coordination polymers.". (2016): http://europepmc.org/abstract/med/27007331.
    10.1039/c6dt00099a
  48. Feliciano, J.R.; Grilo, A.M.; Guerreiro, S.I.; Sousa, S.A.; Leitão, J.H.. "Hfq: A multifaceted RNA chaperone involved in virulence". Future Microbiology 11 1 (2016): 137-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952690345&partnerID=MN8TOARS.
    10.2217/fmb.15.128
  49. Sílvia A. Sousa; Jorge H. Leitão; Raul C. Martins; João M. Sanches; Jasjit S. Suri; Alejandro Giorgetti. "Bioinformatics Applications in Life Sciences and Technologies". BioMed Research International 2016 (2016): 1-2. http://dx.doi.org/10.1155/2016/3603827.
    10.1155/2016/3603827
  50. Gil FN; Moreira-Santos M; Chelinho S; Pereira C; Feliciano JR; Leitão JH; Sousa JP; Ribeiro R; Viegas CA. "Suitability of a Saccharomyces cerevisiae-based assay to assess the toxicity of pyrimethanil sprayed soils via surface runoff: comparison with standard aquatic and soil toxicity assays.". (2015): http://europepmc.org/abstract/med/25461018.
    10.1016/j.scitotenv.2014.09.094
  51. Jorge H. Leitão. "Regulation of Hfq mRNA and protein levels in Escherichia coli and Pseudomonas aeruginosa by the Burkholderia cenocepacia MtvR sRNA". plos one (2014):
    10.1371/journal.pone.0098813
  52. Leitão, Jorge; Sousa, Silvia A.; Grilo, A.M.; Feliciano, J.R.. "Bioinformatics: A Molecular Microbiologist’s Perspective". Current Bioinformatics (2014):
    10.2174/1574893608999140109121908
  53. Couras, C.S.; Louros, V.L.; Grilo, A.M.; Leitão, J.H.; Capela, M.I.; Arroja, L.M.; Nadais, M.H.. "Effects of operational shocks on key microbial populations for biogas production in UASB (Upflow Anaerobic Sludge Blanket) reactors". Energy 73 (2014): 866-874. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905725678&partnerID=MN8TOARS.
    10.1016/j.energy.2014.06.098
  54. Ramos, C.G.; Grilo, A.M.; da Costa, J.P.; Feliciano, J.R.; Leitão, J.H.. "Retraction for ramos et al., MtvR is a global small noncoding regulatory RNA in Burkholderia cenocepacia [J. Bacteriol. 195, 16, (2013) 3514-3523]". Journal of Bacteriology 196 22 (2014): 3981-3981. http://www.scopus.com/inward/record.url?eid=2-s2.0-84917692999&partnerID=MN8TOARS.
    10.1128/JB.02299-14
  55. Ramos, C.G.; Sousa, S.A.; Grilo, A.M.; Feliciano, J.R.; Leitão, J.H.. "Retraction for ramos et al., The second RNA chaperone, Hfq2, is also required for survival under stress and full virulence of Burkholderia cenocepacia J2315 [J. Bacteriol. 193, 7, (2011) 1515-1526]". Journal of Bacteriology 196 22 (2014): 3980-3980. http://www.scopus.com/inward/record.url?eid=2-s2.0-84917695085&partnerID=MN8TOARS.
    10.1128/JB.02242-14
  56. Sousa, S.A.; Feliciano, J.R.; Pinheiro, P.F.; Leitão, J.H.. "Biochemical and Functional Studies on the Burkholderia cepacia Complex bceN Gene, Encoding a GDP-D-Mannose 4,6-Dehydratase". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874519520&partnerID=MN8TOARS.
    10.1371/journal.pone.0056902
  57. Ramos, C.G.; Grilo, A.M.; Da Costa, P.J.P.; Feliciano, J.R.; Leitão, J.H.. "MtvR is a global small noncoding regulatory RNA in Burkholderia cenocepacia". Journal of Bacteriology 195 16 (2013): 3514-3523. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880969985&partnerID=MN8TOARS.
    10.1128/JB.00242-13
  58. Ramos, C.G.; Grilo, A.M.; da Costa, P.J.P.; Leitão, J.H.. "Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315". Genomics 101 2 (2013): 139-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876113265&partnerID=MN8TOARS.
    10.1016/j.ygeno.2012.10.006
  59. Ramos, C.G.; da Costa, P.J.P.; Döring, G.; Leitão, J.H.. "The Novel Cis-Encoded Small RNA h2cR Is a Negative Regulator of hfq2 in Burkholderia cenocepacia". PLoS ONE 7 10 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867651374&partnerID=MN8TOARS.
    10.1371/journal.pone.0047896
  60. Nadais, H.; Barbosa, M.; Capela, I.; Arroja, L.; Ramos, C.G.; Grilo, A.; Sousa, S.A.; Leitão, J.H.. "Enhancing wastewater degradation and biogas production by intermittent operation of UASB reactors". Energy 36 4 (2011): 2164-2168. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952818378&partnerID=MN8TOARS.
    10.1016/j.energy.2010.03.007
  61. Teplitski, M.; Leitão, J.H.; Sela, S.. "Microbial ecology and global health". International Journal of Microbiology (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052465198&partnerID=MN8TOARS.
    10.1155/2011/564701
  62. Sousa, S.A.; Ramos, C.G.; Leitão, J.H.. "Burkholderia cepacia complex: Emerging multihost pathogens equipped with a wide range of virulence factors and determinants". International Journal of Microbiology (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79951969857&partnerID=MN8TOARS.
    10.1155/2011/607575
  63. Mendes, S.; Farinha, A.; Ramos, C.G.; Leitão, J.H.; Viegas, C.A.; Martins, L.O.. "Synergistic action of azoreductase and laccase leads to maximal decolourization and detoxification of model dye-containing wastewaters". Bioresource Technology 102 21 (2011): 9852-9859. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053093583&partnerID=MN8TOARS.
    10.1016/j.biortech.2011.07.108
  64. Ramos, C.G.; Sousa, S.A.; Grilo, A.M.; Feliciano, J.R.; Leitão, J.H.. "The second RNA chaperone, Hfq2, is also required for survival under stress and full virulence of Burkholderia cenocepacia J2315". Journal of Bacteriology 193 7 (2011): 1515-1526. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952810034&partnerID=MN8TOARS.
    10.1128/JB.01375-10
  65. Ramos, C.G.; Grilo, A.M.; Sousa, S.A.; Barbosa, M.L.; Nadais, H.; Leitão, J.H.. "A new methodology combining PCR, cloning, and sequencing of clones discriminated by RFLP for the study of microbial populations: Application to an UASB reactor sample". Applied Microbiology and Biotechnology 85 3 (2010): 801-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-74149086569&partnerID=MN8TOARS.
    10.1007/s00253-009-2268-1
  66. Leitão, J.H.; Sousa, S.A.; Ferreira, A.S.; Ramos, C.G.; Silva, I.N.; Moreira, L.M.. "Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepacia complex pathogens and related species". Applied Microbiology and Biotechnology 87 1 (2010): 31-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952889261&partnerID=MN8TOARS.
    10.1007/s00253-010-2528-0
  67. Sousa, S.A.; Ramos, C.G.; Moreira, L.M.; Leitão, J.H.. "The hfq gene is required for stress resistance and full virulence of Burkholderia cepacia to the nematode Caenorhabditis elegans". Microbiology 156 3 (2010): 896-908. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749301868&partnerID=MN8TOARS.
    10.1099/mic.0.035139-0
  68. Ramos, C.G.; Sousa, S.A.; Grilo, A.M.; Eberl, L.; Leitão, J.H.. "The Burkholderia cenocepacia K56-2 pleiotropic regulator Pbr, is required for stress resistance and virulence". Microbial Pathogenesis 48 5 (2010): 168-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952954310&partnerID=MN8TOARS.
    10.1016/j.micpath.2010.02.006
  69. Ferreira, A.S.; Leitão, J.H.; Silva, I.N.; Pinheiros, P.F.; Sousa, S.A.; Ramos, C.G.; Moreira, L.M.. "Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions". Applied and Environmental Microbiology 76 2 (2010): 441-450. http://www.scopus.com/inward/record.url?eid=2-s2.0-75249087222&partnerID=MN8TOARS.
    10.1128/AEM.01828-09
  70. Sousa, S.A.; Moreira, L.M.; Leitão, J.H.. "Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities". Applied Microbiology and Biotechnology 80 6 (2008): 1015-1022. http://www.scopus.com/inward/record.url?eid=2-s2.0-53249134462&partnerID=MN8TOARS.
    10.1007/s00253-008-1612-1
  71. Leitão, J.H.; Sousa, S.A.; Cunha, M.V.; Salgado, M.J.; Melo-Cristino, J.; Barreto, M.C.; Sá-Correia, I.. "Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected cystic fibrosis patients: A five-year survey in the major Portuguese treatment center". European Journal of Clinical Microbiology and Infectious Diseases 27 11 (2008): 1101-1111. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549117784&partnerID=MN8TOARS.
    10.1007/s10096-008-0552-0
  72. Sousa, S.A.; Ramos, C.G.; Almeida, F.; Meirinhos-Soares, L.; Wopperer, J.; Schwager, S.; Eberl, L.; Leitão, J.H.. "Burkholderia cenocepacia J2315 acyl carrier protein: A potential target for antimicrobials' development?". Microbial Pathogenesis 45 5-6 (2008): 331-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-56749152413&partnerID=MN8TOARS.
    10.1016/j.micpath.2008.08.002
  73. Ferreira, A.S.; Leitão, J.H.; Sousa, S.A.; Cosme, A.M.; Sá-Correia, I.; Moreira, L.M.. "Functional analysis of Burkholderia cepacia genes bceD and bceF, encoding a phospholyrosine phosphatase and a tyrosine autokinase, respectively: Role in exopolysaccharide biosynthesis and biofilm formation". Applied and Environmental Microbiology 73 2 (2007): 524-534. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846443658&partnerID=MN8TOARS.
    10.1128/AEM.01450-06
  74. Sousa, S.A.; Ulrich, M.; Bragonzi, A.; Burke, M.; Worlitzsch, D.; Leitão, J.H.; Meisner, C.; et al. "Virulence of Burkholderia cepacia complex strains in gp91phox-/-mice". Cellular Microbiology 9 12 (2007): 2817-2825. http://www.scopus.com/inward/record.url?eid=2-s2.0-35948975135&partnerID=MN8TOARS.
    10.1111/j.1462-5822.2007.00998.x
  75. Sousa, S.A.; Moreira, L.M.; Wopperer, J.; Eberl, L.; Sá-Correia, I.; Leitão, J.H.. "The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities". Biochemical and Biophysical Research Communications 353 1 (2007): 200-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845659599&partnerID=MN8TOARS.
    10.1016/j.bbrc.2006.12.016
  76. Cunha, M.V.; Sousa, S.A.; Leitão, J.H.; Moreira, L.M.; Videira, P.A.; Sá-Correia, I.. "Studies on the involvement of the exopolysaccharide produced by cystic fibrosis-associated isolates of the Burkholderia cepacia complex in biofilm formation and in persistence of respiratory infections". Journal of Clinical Microbiology 42 7 (2004): 3052-3058. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142721877&partnerID=MN8TOARS.
    10.1128/JCM.42.7.3052-3058.2004
  77. Tavares, I.M.; Leitão, J.H.; Sá-Correia, I.. "Chromosomal organization and transcription analysis of genes in the vicinity of Pseudomonas aeruginosa glmM gene encoding phosphoglucosamine mutase". Biochemical and Biophysical Research Communications 302 2 (2003): 363-371. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037428282&partnerID=MN8TOARS.
    10.1016/S0006-291X(03)00169-4
  78. Sist, P.; Cescutti, P.; Skerlavaj, S.; Urbani, R.; Leitão, J.H.; Sá-Correia, I.; Rizzo, R.. "Macromolecular and solution properties of Cepacian: The exopolysaccharide produced by a strain of Burkholderia cepacia isolated from a cystic fibrosis patient". Carbohydrate Research 338 18 (2003): 1861-1867. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142026900&partnerID=MN8TOARS.
    10.1016/S0008-6215(03)00306-9
  79. Cunha, M.V.; Leitão, J.H.; Mahenthiralingam, E.; Vandamme, P.; Lito, L.; Barreto, C.; Salgado, M.J.; Sá-Correia, I.. "Molecular analysis of Burkholderia cepacia complex isolates from a Portuguese cystic fibrosis center: A 7-year study". Journal of Clinical Microbiology 41 9 (2003): 4113-4120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041919475&partnerID=MN8TOARS.
    10.1128/JCM.41.9.4113-4120.2003
  80. Moreira, L.M.; Videira, P.A.; Sousa, S.A.; Leitão, J.H.; Cunha, M.V.; Sá-Correia, I.. "Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepacia complex exopolysaccharide". Biochemical and Biophysical Research Communications 312 2 (2003): 323-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344845053&partnerID=MN8TOARS.
    10.1016/j.bbrc.2003.10.118
  81. Richau, J.A.; Leitão, J.H.; Correia, M.; Lito, L.; Salgado, M.J.; Barreto, C.; Cescutti, P.; Sá-Correia, I.. "Molecular typing and exopolysaccharide biosynthesis of Burkholderia cepacia isolates from a Portuguese cystic fibrosis center". Journal of Clinical Microbiology 38 4 (2000): 1651-1655. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034000149&partnerID=MN8TOARS.
  82. Richau, J.A.; Leitão, J.H.; Sá-Correia, I.. "Enzymes leading to the nucleotide sugar precursors for exopolysaccharide synthesis in Burkholderia cepacia". Biochemical and Biophysical Research Communications 276 1 (2000): 71-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034675270&partnerID=MN8TOARS.
    10.1006/bbrc.2000.3438
  83. Tavares, I.M.; Jolly, L.; Pompeo, F.; Leitão, J.H.; Fialho, A.M.; Sá-Correia, I.; Mengin-Lecreulx, D.. "Identification of the Pseudomonas aeruginosa glmM gene, encoding phosphoglucosamine mutase". Journal of Bacteriology 182 16 (2000): 4453-4457. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033894595&partnerID=MN8TOARS.
    10.1128/JB.182.16.4453-4457.2000
  84. Cescutti, P.; Bosco, M.; Picotti, F.; Impallomeni, G.; Leitão, J.H.; Richau, J.A.; Sá-Correia, I.. "Structural study of the exopolysaccharide produced by a clinical isolate of Burkholderia cepacia". Biochemical and Biophysical Research Communications 273 3 (2000): 1088-1094. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034647932&partnerID=MN8TOARS.
    10.1006/bbrc.2000.3059
  85. Fialho, A.M.; Martins, L.O.; Donval, M.-L.; Leitão, J.H.; Ridout, M.J.; Jay, A.J.; Morris, V.J.; Sá-Correia, I.. "Structures and properties of gellan polymers produced by Sphingomonas paucimobilis ATCC 31461 from lactose compared with those produced from glucose and from cheese whey". Applied and Environmental Microbiology 65 6 (1999): 2485-2491. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032978642&partnerID=MN8TOARS.
  86. Tavares, I.M.; Leitão, J.H.; Fialho, A.M.; Sá-Correia, I.. "Pattern of changes in the activity of enzymes of GDP-D-mannuronic acid synthesis and in the level of transcription of algA, algC and algD genes accompanying the loss and emergence of mucoidy in Pseudomonas aeruginosa". Research in Microbiology 150 2 (1999): 105-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032709367&partnerID=MN8TOARS.
    10.1016/S0923-2508(99)80028-X
  87. Jay, A.J.; Colquhoun, I.J.; Ridout, M.J.; Brownsey, G.J.; Morris, V.J.; Fialho, A.M.; Leitão, J.H.; Sá-Correia, I.. "Analysis of structure and function of gellans with different substitution patterns". Carbohydrate Polymers 35 3-4 (1998): 179-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032017644&partnerID=MN8TOARS.
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Capítulo de livro
  1. Leitão, Jorge H.; Feliciano, Joana R.; Sousa, Sílvia A.; Pita, Tiago; Guerreiro, Soraia I.. "Burkholderia cepacia Complex Infections Among Cystic Fibrosis Patients: Perspectives and Challenges". In Progress in Understanding Cystic Fibrosis. InTech, 2017.
    10.5772/67712
  2. Leitão, J.H.; Ramos, C.G.; Feliciano, J.R.; Sousa, S.A.; Grilo, A.M.; da Costa, P.J.P.. "Hfq-like RNA chaperones and small non-coding regulatory RNAs: A new paradigm of bacterial gene regulation". 2014.
  3. Leitão, Jorge. "Experimental and bioinformatics approaches to identify potential targets and develop novel strategies to fight infections caused by multiresistant Burkholderia cepacia complex bacteria". In Microbial Pathogens and Human Diseases, 372-383. Espanha: Formatex, 2013.
    Publicado
  4. Ramos, C.G.; Leitão, J.H.. "Caenorhabditis elegans as a research tool to unveil bacterial virulence determinants: Lessons from the Burkholderia cepacia complex". 2012.
  5. Ramos, C.G.; Grilo, A.M.; da Costa, P.J.P.; Nadais, H.; Leitão, J.H.. "Extraction and purification of DNA from UASB reactors sludge samples". 2012.
  6. Leitão, Jorge. "Identification of novel antimicrobials using a live-animal infection model". In Determination of Biological Activities: A Laboratory Manual. Ponta Delgada, Portugal, 2012.
    Publicado
  7. A., Silvia; R., Joana; H., Jorge. "Activated Sugar Precursors: Biosynthetic Pathways and Biological Roles of an Important Class of Intermediate Metabolites in Bacteria". In Biotechnology of Biopolymers. InTech, 2011.
    10.5772/19649
  8. Leitão, Jorge. "Bacterial type II PMIs: exploitable bifunctional enzymes for biotechnological applications and the rational design of antimicrobials". In Biopolymers. Croácia: Intech, 2010.
    Publicado
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018 - 2018 Design, testing, and scale-up of medical device class IIb: risk analysis as a crucial tool for pharmaceutical industry
Coorientador
 Engenharia Farmacêutica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/01/01 - 2017/03/27 Towards the unveiling of the multifarious virulence mechanisms of the Burkholderia cepacia complex: exopolysaccharide biosynthesis, RNA chaperones, and development of an animal infection model
Orientador
 Biotecnologia e Biociências
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Investigating Arx role in mushroom body development in Platynereis dumerilii Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Nanostructured lipid carriers as a delivery system of tobramycin and ciprofloxacin: preparation, testing and validation in the Caenorhabditis elegans model Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Antibacterial activity of camphorimine Ag(I) complexes Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Studies with Vibrio alginolyticus OmpK towards the development of a vaccine for aquacultured Solea senegalensis Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Assessment of anti-parasitic and antibacterial effect of quinoline drugs Microbiologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Natural antimicrobial and antioxidant substances and their application in food and cosmetics Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 The DEAD-box helicase Ded1, an mRNA cap associated protein in yeast Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011/01/02 - 2016/02/03 Role of RNA chaperones and small non-coding RNAs in virulence of Burkholderia cepacia complex
Orientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Development and Evaluation of a novel and innovative drug sensitivity assay for Plasmodium falciparum Microbiologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Effect of the presence of acetic acid and lactic acid at low pH in physiology and virulence of Candida albicans and Candida glabrata: emphasis on the role played by genes of the CgHaa1-regulon Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Identification of Burkholderia cenocepacia K56-2 Virulence-Related sRNAs Using Caenorhabditis elegans Infection Model Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Molecular identification of rhizosphere bacteria from Phragmites sp. growing in a constructed wetland treating benzene derivative compounds Microbiologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Use of rapeseed, coffee and breadcrumbs waste by-products as substrates for microbial production of bioethanol Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Using chimeric viruses to study Kaposi´s Sarcoma Associated Herpesvirus pathogenesis in mice Microbiologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Synthesis and characterization of the antimicrobial activity of two cyclam derivatives Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015 Set-up and comparison of the Droplet Digital PCR method with quantitative RT-PCR in assessing the levels of microRNA-124 from plasma and brain tissue of rats with traumatic brain injury Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2010/06/01 - 2014/07/24 Identification of molecular biomarkers relevant for environmental biomonitoring of pesticide toxicity using simple eukaryotic models
Coorientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2014 Caracterização de populações microbianas em células de combustível para a produção de bioeletricidade Bioengenharia e Nanossistemas (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008/10/01 - 2011/11/02 Role of sRNAs on the virulence of the Burkholderia cepacia complex
Orientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2003/01/01 - 2007/03/23 Burkholderia cepacia complex infections in cystic fibrosis patients: biosynthesis and role of the exopolysaccharide and investigation of other potential virulence factors
Orientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1999/01/01 - 2003/06/06 “Biossíntese de peptidoglicano e alginato em Pseudomonas aeruginosa: análise funcional do gene glmM que codifica a fosfoglucosamina mutase
Coorientador
 Biotecnologia e Biociências (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2018/12/10 Caracterização microbiológica e molecular das estirpes de Salmonella spp. isoladas em amostras clínicas, águas residuais e alimentos na região de Luanda e dos seus perfis de resistência aos antimicrobianos – o seu impacto na saúde pública
Vogal
 Moisés Francisco (Doutoramento)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017/03/27 Towards the unveiling of the multifarious virulence mechanisms of the Burkholderia cepacia complex: exopolysaccharide biosynthesis, RNA chaperones, and development of an animal infection model
Orientador
 Joana Rita Rodrigues Feliciano (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/07/18 Characterization of genes of unknown function in Bacillus subtilis: gene regulation and functional analysis
Arguente principal
 Lia Raquel Marques Godinho (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/04/29 Chronic respiratory infections by Burkholderia cepacia complex bacteria in cystic fibrosis patients: epidemiology and variation of virulence, membrane lipid and metabolite profiles during long-term residence in the lungs
Vogal
 Ana Sílvia Soares Mendes Moreira (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/02/22 Insights into bacterial colony morphology evolution and diversification during infection development in cystic fibrosis
Arguente
 Ana Margarida Rodrigues de Sousa (Doutoramento)
Universidade do Minho, Portugal
2016 Identification and characterization of small non-coding RNAs from bacteria of the Burkholderia cepacia complex
Orientador
 André Manuel Sardinha Grilo (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/12/16 Interference of Mycobacterium tuberculosis with the endocytic/ antigen presentation pathways on macrophages and dendritic cells
Arguente
 David Alexandre Rodrigues Pires (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/07/30 Human factors required for Mycobacterium tuberculosis macrophage infection
Arguente
 Nuno Baltazar do Carmo (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 Analysis of a role of the LysR-type regulator ShvR in virulence of Burkholderia cenocepacia using zebrafish as a model Margarida Castro Gomes (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/12/10 Insights into the ecology of polymicrobial biofilms involved in cystic fibrosis
Arguente
 Susana Patrícia Peixoto Lopes (Doutoramento)
Universidade do Minho, Portugal
2013/10/17 Bacterial protein azurin as a new therapeutic tool to treat poor prognosis breast cancer with overexpression of P-cadherin
Arguente
 Nuno Filipe Santos Bernardes (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/07/03 Precious transition metals: The importance of Zn2+, Mn2+ and Cu2+ in the human pathogen Enterococcus faecalis
Arguente principal
 Marta Coelho Abrantes (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/03/20 Burkholderia cenocepacia pathogenesis: unraveling the virulence functions of trimeric autotransporter adhesins and development of alternative therapies to target this pathogen
Arguente
 Dalila Madeira do Nascimento Mil-Homens (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/01/20 Impacto of herbicides on non-target organisms in sustainable rice production systems: effects of bentazon and molinate on the autochtonous cyanobacteria Anabaena cylindrica and Nostoc muscorum
Arguente
 Victor Manuel Fernandes Galhano (Doutoramento)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2011/12/21 Cyanobacterial extracellular polymeric substances (EPS): insights in the production/biosynthesis and applications in heavy metals recovery
Arguente principal
 Sara Bernardes Pereira (Doutoramento)
Universidade do Porto, Portugal
2011/11 Roles played by Hfq-like RNA chaperones and sRNAs on the virulence of Burkholderia cepacia complex bacteria
Orientador
 Christian Gomes da Silva Ramos (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011/01/28 Functional studies on bolA and related genes: increasing the understanding of a protein with pleiotropic effects
Arguente
 Inês Batista Guinote (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/12/14 Genomic and transcriptomic features of Chlamydia trachomatis: tracking the basis for the ecological success
Arguente
 Alexandra Isabel Cardoso Nunes (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/01 Regulation and biosynthesis of the exopolysaccharide cepacian by Burkholderia strains
Arguente
 Ana Sofia de Jesus Ferreira (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2009/01 Functional analysis of the outer membrane protein TolC from Sinorhizobium meliloti: role in protein secretion, polysaccharide biosynthesis and symbiosis
Arguente
 Ana Maria Cosme (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008/11 The antimycobacterial activity of thioridazine derivatives against drug resistant Mycobacterium tuberculosis: in vitro, ex vivo and in vivo studies
Vogal
 Marta Sofia Lopes Martins (Doutoramento)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2006 Characterization of the gene bolA and its function in cell morphology and survival
Vogal
 Patrick de Oliveira Freire (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2004 O complexo Burkholderia cepacia em infecções respiratórias de doentes portugueses com fibrose quística: epidemiologia molecular, resistência a antibióticos e presumíveis factores de virulência e persistência da infecção
Vogal
 Mónica Sofia Vieira Cunha (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2002/02 Burkholderia cepacia nas infecções respiratórias de doentes portugueses com fibrose quística: epidemiologia molecular e biossíntese de exopolissacárido
Vogal
 João António Richau Cagarrinho (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019/06/01 - 2024/12/31 International Journal of Molecular Sciences (1573-0972) MDPI
2019/09/01 - 2020/05/31 Vaccines (2076-393X) MDPI AG
2019/10/01 - 2020/03/31 Antibiotics (2079-6382) MDPI AG

Membro de associação

Nome da associação Tipo de participação
2005/01/01 - Atual Sociedade Portuguesa de Microbiologia Sócio
1989/01/01 - Atual Sociedade Portuguesa de Biotecnologia
Distinções

Outra distinção

2017 Docente Excelente
Universidade de Lisboa Instituto Superior Técnico, Portugal