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Identificação

Identificação pessoal

Nome completo
Maria da Graça Beça Gonçalves Porto

Nomes de citação

  • Porto, Graça

Identificadores de autor

Ciência ID
431B-A46D-D7A0
ORCID iD
0000-0002-1923-4638
Formação
Grau Classificação
2005
Concluído
 Fisiopatologia (Título de Agregado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1995
Concluído
 Imuno-Hemoterapia (Título de Habilitação de Coordenação Científica)
Centro Hospitalar Universitário do Porto EPE, Portugal
1994
Concluído
 Imunologia (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1989
Concluído
 Imuno-hemoterapia (Título de especialista)
Centro Hospitalar Universitário do Porto EPE, Portugal
1979
Concluído
 Medicina (Licenciatura)
Universidade do Porto Faculdade de Medicina, Portugal
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2005 - Atual Professor Catedrático Convidado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1994 - 2005 Professor Associado Convidado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/01/02 - Atual Research Group Director Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2005 - Atual Director - Serviço de Imuno-hemoterapia Centro Hospitalar Universitário do Porto EPE, Portugal
1989 - 1995 Specialist - Hematology Centro Hospitalar Universitário do Porto EPE, Portugal
Projetos

Bolsa

Designação Financiadores
2016/01/01 - 2018/12/31 “Pathogenesis of arthropathy in hereditary hemochromatosis: a clinical and experimental approach”
NORTE-01-0145-FEDER-000012
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Concluído
2013/01/01 - 2016/12/31 “Modifiers of Expression of Hemochromatosis: looking for new markers of disease prognosis”
CHP 143/12 (112-DEFI/103-CES):
Investigador responsável
Centro Hospitalar Universitário do Porto EPE Centro Materno-Infantil do Norte Dr Albino Aroso, Portugal
Concluído
2009 - 2012 “Modifiers of expression of hemochromatosis: looking for new markers of disease prognosis”
PIC/IC/82785/2007
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Concluído
2008 - 2011 “The Genetics of CD8+ T lymphocyte homeostasis: implications in the clinical expression of Hereditary Hemochromatosis”
PTDC/SAU-GMG/67868/2006:
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Concluído
2008 - 2011 “The Genetics of CD8+ T lymphocyte homeostasis: implications in the clinical expression of Hereditary Hemochromatosis”
PTDC/SAU-GMG/67868/2006:
 N/A
2005 - 2008 “Hemochromatosis HFE and non-HFE: Basic and clinical aspects”
PDCT/MGI/50407/2005
Investigador responsável
Concluído
2001 - 2004 “HFE mutations and HLA polymorphisms: a population based study”
POCTI/32986/MGI/2000
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Concluído
1997 - 1999 “Study of HLA-H gene mutations in hemochromatosis patients: implications to the immunological abnormalities and disease heterogeneity”
PRAXIS/PSAU/P/SAU/98/96
Investigador responsável
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Concluído
1996 - 1999 “Clinical implications of iron overload: hemochromatosis as a model”
PECS/C/SAU/59/95
Investigador responsável
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Concluído
Produções

Publicações

Artigo em revista
  1. Ana C. Moreira; Teles MJ; Tânia Silva; Clara M. Bento; Inês Simões Alves; Pereira L; João Tiago Guimarães; et al. "Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection". Viruses (2021): https://www.mdpi.com/1999-4915/13/12/2482.
    10.3390/v13122482
  2. Ferreira, A.V.; Duarte, T.L.; Marques, S.; Costa, P.; Neves, S.C.; dos Santos, T.; Granja, P.L.; Porto, G.. "Iron triggers the early stages of cartilage degeneration in vitro: The role of articular chondrocytes". Osteoarthritis and Cartilage Open 3 2 (2021): 100145. http://dx.doi.org/10.1016/j.ocarto.2021.100145.
    10.1016/j.ocarto.2021.100145
  3. Barton, James C.; Barton, J. Clayborn; Cruz, Eugénia; Teles, Maria José; Guimarães, João T.; Porto, Graça. "Chromosome 6p SNP microhaplotypes and IgG3 levels in hemochromatosis probands with HFE p.C282Y homozygosity". Blood Cells, Molecules, and Diseases 85 (2020): 102461. http://dx.doi.org/10.1016/j.bcmd.2020.102461.
    10.1016/j.bcmd.2020.102461
  4. Vinchi, Francesca; Porto, Graca; Simmelbauer, Andreas; Altamura, Sandro; Passos, Sara T; Garbowski, Maciej; Silva, André M N; et al. "Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction". European Heart Journal (2019): http://dx.doi.org/10.1093/eurheartj/ehz112.
    10.1093/eurheartj/ehz112
  5. Lim, P.J.; Duarte, T.L.; Arezes, J.; Garcia-Santos, D.; Hamdi, A.; Pasricha, S.-R.; Armitage, A.E.; et al. "Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin". Nature Metabolism 1 5 (2019): 519-531. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071448817&partnerID=MN8TOARS.
    10.1038/s42255-019-0063-6
  6. Simão, M.; Gavaia, P.J.; Camacho, A.; Porto, G.; Pinto, I.J.; Ea, H.-K.; Cancela, M.L.. "Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype". BioFactors 45 4 (2019): 583-597. http://www.scopus.com/inward/record.url?eid=2-s2.0-85070580966&partnerID=MN8TOARS.
    10.1002/biof.1520
  7. Porto, G.; Cruz, E.; Teles, M.J.; de Sousa, M.. "HFE related hemochromatosis: Uncovering the inextricable link between iron homeostasis and the immunological system". Pharmaceuticals 12 3 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073389026&partnerID=MN8TOARS.
    10.3390/ph12030122
  8. Simão, M.; Camacho, A.; Ostertag, A.; Cohen-Solal, M.; Pinto, I.J.; Porto, G.; Ea, H.-K.; Cancela, M.L.. "Correction: Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis (PLoS ONE (2018) 13: 11 (e0207441) DOI: 10.1371/journal.pone.0207441)". PLoS ONE 14 4 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85065427994&partnerID=MN8TOARS.
    10.1371/journal.pone.0216377
  9. França, M.; Martí-Bonmatí, L.; Silva, S.; Oliveira, C.; Alberich Bayarri, Á.; Vilas Boas, F.; Pessegueiro-Miranda, H.; Porto, G.. "Optimizing the management of hereditary haemochromatosis: the value of MRI R2* quantification to predict and monitor body iron stores". British Journal of Haematology 183 3 (2018): 491-493. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032351854&partnerID=MN8TOARS.
    10.1111/bjh.14982
  10. França, M.; Martí-Bonmatí, L.; Porto, G.; Silva, S.; Guimarães, S.; Alberich-Bayarri, Á.; Vizcaíno, J.R.; Pessegueiro Miranda, H.. "Tissue iron quantification in chronic liver diseases using MRI shows a relationship between iron accumulation in liver, spleen, and bone marrow". Clinical Radiology 73 2 (2018): 215.e1-215.e9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028474770&partnerID=MN8TOARS.
    10.1016/j.crad.2017.07.022
  11. Adams, P.; Altes, A.; Brissot, P.; Butzeck, B.; Cabantchik, I.; Cançado, R.; Distante, S.; et al. "Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype". Hepatology International 12 2 (2018): 83-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044480865&partnerID=MN8TOARS.
    10.1007/s12072-018-9855-0
  12. Simão, M.; Camacho, A.; Ostertag, A.; Cohen-Solal, M.; Jorge Pinto, I.; Porto, G.; Hang Korng, E.; Leonor Cancela, M.. "Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis". PLoS ONE 13 11 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85056651093&partnerID=MN8TOARS.
    10.1371/journal.pone.0207441
  13. Pasricha, S.-R.; Lim, P.J.; Duarte, T.L.; Casu, C.; Oosterhuis, D.; Mleczko-Sanecka, K.; Suciu, M.; et al. "Hepcidin is regulated by promoter-associated histone acetylation and HDAC3". Nature Communications 8 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85028636590&partnerID=MN8TOARS.
    10.1038/s41467-017-00500-z
  14. Marques, O.; Canadas, A.; Faria, F.; Oliveira, E.; Amorim, I.; Seixas, F.; Gama, A.; et al. "Expression of iron-related proteins in feline and canine mammary gland reveals unexpected accumulation of iron". Biotechnic and Histochemistry (2017): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035104892&partnerID=MN8TOARS.
    10.1080/10520295.2017.1369160
  15. França, M.; Alberich-Bayarri, Á.; Martí-Bonmatí, L.; Oliveira, P.; Costa, F.E.; Porto, G.; Vizcaíno, J.R.; et al. "Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI". Abdominal Radiology (2017): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009854488&partnerID=MN8TOARS.
    10.1007/s00261-017-1048-0
  16. Duarte, T.L.; Caldas, C.; Santos, A.G.; Silva-Gomes, S.; Santos-Gonçalves, A.; Martins, M.J.; Porto, G.; Lopes, J.M.. "Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis". Redox Biology 11 (2017): 157-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002982394&partnerID=MN8TOARS.
    10.1016/j.redox.2016.11.013
  17. Porto, G.; Brissot, P.; Swinkels, D.W.; Zoller, H.; Kamarainen, O.; Patton, S.; Alonso, I.; Morris, M.; Keeney, S.. "EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH)". European Journal of Human Genetics 24 4 (2016): 479-495. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960397668&partnerID=MN8TOARS.
    10.1038/ejhg.2015.128
  18. Marques, O.; Rosa, A.; Leite, L.; Faustino, P.; Rêma, A.; Martins da Silva, B.; Porto, G.; Lopes, C.. "HFE Variants and the Expression of Iron-Related Proteins in Breast Cancer-Associated Lymphocytes and Macrophages". Cancer Microenvironment 9 2-3 (2016): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007506814&partnerID=MN8TOARS.
    10.1007/s12307-016-0191-4
  19. Marques, O.; Porto, G.; Rêma, A.; Faria, F.; Cruz Paula, A.; Gomez-Lazaro, M.; Silva, P.; Martins da Silva, B.; Lopes, C.. "Local iron homeostasis in the breast ductal carcinoma microenvironment". BMC Cancer 16 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84959276692&partnerID=MN8TOARS.
    10.1186/s12885-016-2228-y
  20. Couto, D.; Sousa, R.; Andrade, L.; Leander, M.; Lopez-Quintela, M.A.; Rivas, J.; Freitas, P.; et al. "Polyacrylic acid coated and non-coated iron oxide nanoparticles are not genotoxic to human T lymphocytes". Toxicology Letters 234 2 (2015): 67-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923079887&partnerID=MN8TOARS.
    10.1016/j.toxlet.2015.02.010
  21. Nazareth, T.; Sousa, C.A.; Porto, G.; Gonçalves, L.; Seixas, G.; Antunes, L.; Silva, A.C.; Teodósio, R.. "Impact of a Dengue Outbreak Experience in the Preventive Perceptions of the Community from a Temperate Region: Madeira Island, Portugal". PLoS Neglected Tropical Diseases 9 3 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928794605&partnerID=MN8TOARS.
    10.1371/journal.pntd.0003395
  22. Costa, M.; Cruz, E.; Oliveira, S.; Benes, V.; Ivacevic, T.; Silva, M.J.; Vieira, I.; et al. "Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of hfe as a negative regulator of cd8+ t-Lymphocyte activation and differentiation in vivo". PLoS ONE 10 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928335492&partnerID=MN8TOARS.
    10.1371/journal.pone.0124246
  23. Couto, D.; Freitas, M.; Porto, G.; Lopez-Quintela, M.A.; Rivas, J.; Freitas, P.; Carvalho, F.; Fernandes, E.. "Polyacrylic acid-coated and non-coated iron oxide nanoparticles induce cytokine activation in human blood cells through TAK1, p38 MAPK and JNK pro-inflammatory pathways". Archives of Toxicology 89 10 (2015): 1759-1769. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942195290&partnerID=MN8TOARS.
    10.1007/s00204-014-1325-4
  24. Maia, M.L.; Pereira, C.S.; Melo, G.; Pinheiro, I.; Exley, M.A.; Porto, G.; Macedo, M.F.. "Invariant Natural Killer T Cells are Reduced in Hereditary Hemochromatosis Patients". Journal of Clinical Immunology 35 1 (2015): 68-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925510182&partnerID=MN8TOARS.
    10.1007/s10875-014-0118-0
  25. Couto, D.; Freitas, M.; Vilas-Boas, V.; Dias, I.; Porto, G.; Lopez-Quintela, M.A.; Rivas, J.; et al. "Interaction of polyacrylic acid coated and non-coated iron oxide nanoparticles with human neutrophils". Toxicology Letters 225 1 (2014): 57-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890396434&partnerID=MN8TOARS.
    10.1016/j.toxlet.2013.11.020
  26. Marques, O.; da Silva, B.M.; Porto, G.; Lopes, C.. "Iron homeostasis in breast cancer". Cancer Letters 347 1 (2014): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897030816&partnerID=MN8TOARS.
    10.1016/j.canlet.2014.01.029
  27. Crespo, T.C.; Silva, B.; Marques, L.; Marcelino, E.; Maruta, C.; Costa, S.; Timóteo, T.; et al. "Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation". Neurobiology of Aging 35 4 (2014): 777-785. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891373826&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2013.10.078
  28. Pinto, J.P.; Arezes, J.; Dias, V.; Oliveira, S.; Vieira, I.; Costa, M.; Vos, M.; et al. "Physiological implications of NTBI uptake by T lymphocytes". Frontiers in Pharmacology 5 FEB (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84895529998&partnerID=MN8TOARS.
    10.3389/fphar.2014.00024
  29. Leandro, B.; Paneque, M.; Sequeiros, J.; Porto, G.. "Insufficient Referral for Genetic Counseling in the Management of Hereditary Haemochromatosis in Portugal: A Study of Perceptions of Health Professionals Requesting HFE Genotyping". Journal of Genetic Counseling (2014): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891553586&partnerID=MN8TOARS.
    10.1007/s10897-013-9681-4
  30. Nazareth, T.; Teodósio, R.; Porto, G.; Gonçalves, L.; Seixas, G.; Silva, A.C.; Sousa, C.A.. "Strengthening the perception-assessment tools for dengue prevention: A cross-sectional survey in a temperate region Madeira, Portugal". BMC Public Health 14 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893392510&partnerID=MN8TOARS.
    10.1186/1471-2458-14-39
  31. Ribeiro, D.; Freitas, M.; Tomé, S.M.; Silva, A.M.S.; Porto, G.; Cabrita, E.J.; Marques, M.M.B.; Fernandes, E.. "Inhibition of LOX by flavonoids: A structure-activity relationship study". European Journal of Medicinal Chemistry 72 (2014): 137-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890960018&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.11.030
  32. Teixeira, E.; Borlido-Santos, J.; Brissot, P.; Butzeck, B.; Courtois, F.; Evans, R.W.; Fernau, J.; et al. "The importance of the general practitioner as an information source for patients with hereditary haemochromatosis". Patient Education and Counseling 96 1 (2014): 86-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902273236&partnerID=MN8TOARS.
    10.1016/j.pec.2014.04.017
  33. Bettencourt, B.F.; Rocha, F.L.; Alves, H.; Amorim, R.; Caetano-Lopes, J.; Vieira-Sousa, E.; Pimentel-Santos, F.; et al. "Protective effect of an ERAP1 haplotype in ankylosing spondylitis: Investigating non-MHC genes in HLA-B27-positive individuals". Rheumatology (United Kingdom) 52 12 (2013): 2168-2176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887669101&partnerID=MN8TOARS.
    10.1093/rheumatology/ket269
  34. Roetto, A.; Porto, G.. "A novel mutation in the CUB sequence of matriptase-2 (TMPRSS6) is implicated in iron-resistant iron deficiency anaemia - response to Jaspers et al". British Journal of Haematology 160 4 (2013): 566-567. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873087970&partnerID=MN8TOARS.
    10.1111/bjh.12145
  35. Costa, M.; Cruz, E.; Barton, J.C.; Thorstensen, K.; Morais, S.; Da Silva, B.M.; Pinto, J.P.; et al. "Effects of highly conserved major histocompatibility complex (MHC) extended haplotypes on iron and low CD8+ T lymphocyte phenotypes in HFE C282Y homozygous hemochromatosis patients from three geographically distant areas". PLoS ONE 8 11 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891891855&partnerID=MN8TOARS.
    10.1371/journal.pone.0079990
  36. Freitas, M.; Costa, V.M.; Ribeiro, D.; Couto, D.; Porto, G.; Carvalho, F.; Fernandes, E.. "Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils". Toxicology Letters 219 2 (2013): 170-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876313471&partnerID=MN8TOARS.
    10.1016/j.toxlet.2013.03.007
  37. Arezes, J.; Costa, M.; Vieira, I.; Dias, V.; Kong, X.L.; Fernandes, R.; Vos, M.; et al. "Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: Evidence for the selective acquisition of oligomeric ferric citrate species". PLoS ONE 8 11 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891893020&partnerID=MN8TOARS.
    10.1371/journal.pone.0079870
  38. Ribeiro, D.; Freitas, M.; Tomé, S.M.; Silva, A.M.S.; Porto, G.; Fernandes, E.. "Modulation of human neutrophils' oxidative burst by flavonoids". European Journal of Medicinal Chemistry 67 (2013): 280-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882515383&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.06.019
  39. Pellegrino, R.M.; Coutinho, M.; D'Ascola, D.; Lopes, A.M.; Palmieri, A.; Carnuccio, F.; Costa, M.; et al. "Two novel mutations in the tmprss6 gene associated with iron-refractory iron-deficiency anaemia (irida) and partial expression in the heterozygous form". British Journal of Haematology 158 5 (2012): 668-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865112610&partnerID=MN8TOARS.
    10.1111/j.1365-2141.2012.09198.x
  40. Gomes, A.; Couto, D.; Alves, A.; Dias, I.; Freitas, M.; Porto, G.; Duarte, J.A.; Fernandes, E.. "Trihydroxyflavones with antioxidant and anti-inflammatory efficacy". BioFactors 38 5 (2012): 378-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867684223&partnerID=MN8TOARS.
    10.1002/biof.1033
  41. Freitas, M.; Lima, J.L.F.C.; Porto, G.; Fernandes, E.. "Metal-induced oxidative burst in isolated human neutrophils". Microchemical Journal 96 1 (2010): 167-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955559263&partnerID=MN8TOARS.
    10.1016/j.microc.2010.03.002
  42. Freitas, M.; Gomes, A.; Porto, G.; Fernandes, E.. "Nickel induces oxidative burst, NF-¿B activation and interleukin-8 production in human neutrophils". Journal of Biological Inorganic Chemistry 15 8 (2010): 1275-1283. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649960929&partnerID=MN8TOARS.
    10.1007/s00775-010-0685-3
  43. Beirão, I.; Moreira, L.; Barandela, T.; Lobato, L.; Silva, P.; Gouveia, C.M.; Carneiro, F.; et al. "Erythropoietin production by distal nephron in normal and familial amyloidotic adult human kidneys". Clinical Nephrology 74 5 (2010): 327-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649902510&partnerID=MN8TOARS.
  44. Freitas, M.; Porto, G.; Lima, J.L.F.C.; Fernandes, E.. "Zinc activates neutrophils' oxidative burst". BioMetals 23 1 (2010): 31-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949424370&partnerID=MN8TOARS.
    10.1007/s10534-009-9264-x
  45. MacEdo, M.F.; Porto, G.; Costa, M.; Vieira, C.P.; Rocha, B.; Cruz, E.. "Low numbers of CD8 + T lymphocytes in hereditary haemochromatosis are explained by a decrease of the most mature CD8 + effector memory T cells". Clinical and Experimental Immunology 159 3 (2010): 363-371. http://www.scopus.com/inward/record.url?eid=2-s2.0-74549195700&partnerID=MN8TOARS.
    10.1111/j.1365-2249.2009.04066.x
  46. Neves, J.V.; Olsson, I.A.S.; Porto, G.; Rodrigues, P.N.. "Hemochromatosis and pregnancy: Iron stores in the Hfe-/- mouse are not reduced by multiple pregnancies". American Journal of Physiology - Gastrointestinal and Liver Physiology 298 4 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77950193716&partnerID=MN8TOARS.
    10.1152/ajpgi.00449.2009
  47. Pinto, J.P.; Dias, V.; Zoller, H.; Porto, G.; Carmo, H.; Carvalho, F.; De Sousa, M.. "Hepcidin messenger RNA expression in human lymphocytes". Immunology 130 2 (2010): 217-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952061000&partnerID=MN8TOARS.
    10.1111/j.1365-2567.2009.03226.x
  48. Porto, B.; Vieira, R.; Porto, G.. "Increased capacity of lymphocytes from hereditary hemochromatosis patients homozygous for the C282Y HFE mutation to respond to the genotoxic effect of diepoxybutane". Mutation Research - Genetic Toxicology and Environmental Mutagenesis 673 1 (2009): 37-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-58949102761&partnerID=MN8TOARS.
    10.1016/j.mrgentox.2008.11.016
  49. Freitas, M.; Porto, G.; Lima, J.L.F.C.; Fernandes, E.. "Optimization of experimental settings for the analysis of human neutrophils oxidative burst in vitro". Talanta 78 4-5 (2009): 1476-1483. http://www.scopus.com/inward/record.url?eid=2-s2.0-63949083263&partnerID=MN8TOARS.
    10.1016/j.talanta.2009.02.050
  50. Correia, A.P.; Pinto, J.P.; Dias, V.; Mascarenhas, C.; Almeida, S.; Porto, G.. "CAT53 and HFE alleles in Alzheimer's disease: A putative protective role of the C282Y HFE mutation". Neuroscience Letters 457 3 (2009): 129-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349270547&partnerID=MN8TOARS.
    10.1016/j.neulet.2009.03.088
  51. Pinto, J.P.; Ramos, P.; de Almeida, S.F.; Oliveira, S.; Breda, L.; Michalak, M.; Porto, G.; Rivella, S.; de Sousa, M.. "Protective role of calreticulin in HFE hemochromatosis". Free Radical Biology and Medicine 44 1 (2008): 99-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-36249031555&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2007.09.014
  52. Freitas, M.; Porto, G.; Lima, J.L.F.C.; Fernandes, E.. "Isolation and activation of human neutrophils in vitro. The importance of the anticoagulant used during blood collection". Clinical Biochemistry 41 7-8 (2008): 570-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-41949102130&partnerID=MN8TOARS.
    10.1016/j.clinbiochem.2007.12.021
  53. Cruz, E.; Whittington, C.; Krikler, S.H.; Mascarenhas, C.; Lacerda, R.; Vieira, J.; Porto, G.. "A new 500 kb haplotype associated with high CD8+ T-lymphocyte numbers predicts a less severe expression of hereditary hemochromatosis.". BMC medical genetics 9 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-59649091028&partnerID=MN8TOARS.
    10.1186/1471-2350-9-97
  54. Pinto, J.P.; Ribeiro, S.; Pontes, H.; Thowfeequ, S.; Tosh, D.; Carvalho, F.; Porto, G.. "Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPa". Blood 111 12 (2008): 5727-5733. http://www.scopus.com/inward/record.url?eid=2-s2.0-47049116150&partnerID=MN8TOARS.
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  55. Beirão, I.; Moreira, L.; Porto, G.; Lobato, L.; Fonseca, I.; Cabrita, A.; Costa, P.M.P.. "Low erythropoietin production in familial amyloidosis TTR V30M is not related with renal congophilic amyloid deposition: A clinicopathologic study of twelve cases". Nephron - Clinical Practice 109 2 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-48249126810&partnerID=MN8TOARS.
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  56. Beirão, I.; Almeida, S.; Swinkels, D.; Costa, P.M.P.; Moreira, L.; Fonseca, I.; Freitas, C.; Cabrita, A.; Porto, G.. "Low serum levels of prohepcidin, but not hepcidin-25, are related to anemia in familial amyloidosis TTR V30M". Blood Cells, Molecules, and Diseases 41 2 (2008): 175-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-48749088914&partnerID=MN8TOARS.
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  57. Beirão, I.; Lobato, L.; Moreira, L.; Costa, P.M.P.; Fonseca, I.; Cabrita, A.; Porto, G.. "Long-term treatment of anemia with recombinant human erythropoietin in familial amyloidosis TTR V30M". Amyloid 15 3 (2008): 205-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-54249100410&partnerID=MN8TOARS.
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  80. Cardoso, C.; Porto, G.; Lacerda, R.; Resende, D.; Rodrigues, P.; Bravo, F.; Oliveira, J.C.; Justiça, B.; De Sousa, M.. "T-cell receptor repertoire in hereditary hemochromatosis: A study of 32 hemochromatosis patients and 274 healthy subjects". Human Immunology 62 5 (2001): 488-499. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035026079&partnerID=MN8TOARS.
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Livro
  1. Drakesmith, H.; Porto, G.; de Sousa, M.. Iron and the immune system. 2012.
    10.1007/978-1-60327-485-2_12
  2. Porto, G.; Da Silva, B.M.; Vicente, C.; Branco, H.; Fraga, J.; Soares, J.M.; De Sousa, M.. Hereditary Hemochromatosis (HH) in the North of Portugal: 2. HLA Haplotypes Found in First Six Families Studied. 1988.
    10.1111/j.1749-6632.1988.tb55525.x
  3. De Sousa, M.; Porto, G.; Fraga, J.; Da Silva, B.M.; Lacerda, R.; Santos, C.; Serráo, D.; Salgadinho, A.; Vicente, C.. Hereditary Hemochromatosis (HH) in the North of Portugal: 1. Preliminary Characterization of First 15 Cases. 1988.
    10.1111/j.1749-6632.1988.tb55524.x
Atividades

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2009 - 2009 BioIron 2009 - 3th Congress of the International BioIron Society (2009/06/08 - 2009/06/11)
Congresso (Presidente da Comissão Organizadora)
2002 - 2002 European Iron Club Meeting 2002 (2002 - 2002)
Congresso (Presidente da Comissão Organizadora)
1990 - 1990 European Iron Club Meeting 1990 (1990 - 1990)
Congresso (Presidente da Comissão Organizadora)

Arbitragem científica em conferência

Nome da conferência Local da conferência
2021/06/09 - 2021/06/17 26th Congress of the EuropeanHaematology Association(EHA2021 Virtual) European Haematology Association
2019 - 2020 25th Congress of the European Hematology Association (EHA)
2018 - 2019 24th Congress of the European Hematology Association (EHA)
2017 - 2018 23th Congress of the European Hematology Association (EHA)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2010 - 2018 GABBA - Graduate Program on Basic and Applied Biology Module - "Iron Biology" Iron Biology (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal