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Gil Levkowitz received his BSc. and MSc. from Tel Aviv University in Israel. He conducted his Ph.D. research in Prof. Yosef Yarden’s laboratory at the Weizmann Institute of Science focusing on epidermal growth factor receptor (EGFR) signaling, and earned his Ph.D. degree at 2000. He was a Post-Doctoral Fellow (2000-2002) in Arnon Rosenthal’s laboratory at Genentech Inc., (South San Francisco, USA) where he studied the embryonic development of the dopamine- secreting [termed ‘dopaminergic’] neuronal cell type, which is associated with Parkinson’s disease as well as other neurological disorders. He then spent approximately two years (2002-2003) as a project team leader at Rinat-Neuroscience Corp. in Palo Alto, USA (now Rinat-Pfizer Inc.), conducting research and pre-clinical development of drugs for Alzheimer’s and Parkinson’s diseases. Since returning to Israel he has been a Senior Scientist and then an Associate Professor at the Weizmann Institute. His lab is using zebrafish to study genetic pathways controlling hypothalamic neuronal circuits that have been associated with neurological conditions such as depression, chronic stress, autism and obesity. Prof. Levkowitz is the incumbent of the Elias Sourasky Professorial Chair.
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Identificação

Identificação pessoal

Nome completo
Gil Levkowitz

Identificadores de autor

Ciência ID
5611-5DC0-F794
ORCID iD
0000-0002-3896-1881
Formação
Grau Classificação
2002
Concluído
 Developmental Neurobiology (Pós-doutoramento)
Genentech Inc, Estados Unidos
2000
Concluído
 Growth Factors Signaling (Doctor of Philosophy)
Weizmann Institute of Science, Israel
1993
Concluído
 Developmental Neurobiology (Master)
Tel Aviv University, Israel
1991
Concluído
 Biology (Bachelor)
Tel Aviv University, Israel
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2004/01/01 - Atual Investigador principal (carreira) (Investigação) Weizmann Institute of Science, Israel
2000/05/01 - 2002/05/01 Pós-doutorado (Investigação) Genentech Inc, Estados Unidos
Genentech Inc, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/06/01 - Atual Professor Associado (Docente Universitário) Weizmann Institute of Science, Israel

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2002/06/01 - 2003/01/01 Project Team Leader Rinat Pfizer Global Research and Development, Estados Unidos
Rinat Pfizer Global Research and Development, Estados Unidos
Produções

Publicações

Artigo em revista
  1. Ana Rita Nunes; Michael Gliksberg; Susana A.M. Varela; Magda Teles; Einav Wircer; Janna Blechman; Giovanni Petri; et al. "Developmental effects of oxytocin neurons on social affiliation and processing of social information". The Journal of Neuroscience (2021): JN--RM--2939--20-JN--RM--2939--20. https://doi.org/10.1523%2Fjneurosci.2939-20.2021.
    10.1523/jneurosci.2939-20.2021
  2. Ludmila Gordon; Gil Levkowitz. "Through the Open Window: How Does the Brain Talk to the Body?". Frontiers for Young Minds 9 (2021): https://doi.org/10.3389%2Ffrym.2021.534184.
    10.3389/frym.2021.534184
  3. Ribeiro D; Nunes AR; Teles M; Anbalagan S; Blechman J; Levkowitz G; Oliveira RF; Levkowitz, Gil. "Genetic variation in the social environment affects behavioral phenotypes of oxytocin receptor mutants in zebrafish.". eLife (2020): http://europepmc.org/abstract/med/32902385.
    10.7554/elife.56973
  4. Shlomo Wagner; Valery Grinevich; Gil Levkowitz. "Advances in Neurohypophysial Hormones Research". Journal of Neuroendocrinology (2020): e12853-e12853. https://doi.org/10.1111%2Fjne.12853.
    10.1111/jne.12853
  5. Ana Rita Nunes; Leonor Carreira; Savani Anbalagan; Janna Blechman; Gil Levkowitz; Rui F. Oliveira. "Perceptual mechanisms of social affiliation in zebrafish". Scientific Reports 10 1 (2020): https://doi.org/10.1038%2Fs41598-020-60154-8.
    10.1038/s41598-020-60154-8
  6. Qiyu Chen; Dena Leshkowitz; Janna Blechman; Gil Levkowitz. "Single-cell molecular and cellular architecture of the mouse neurohypophysis". eneuro (2020): ENEURO.0345-19.2019. https://doi.org/10.1523%2Feneuro.0345-19.2019.
    10.1523/eneuro.0345-19.2019
  7. Diogo Ribeiro; Ana Rita Nunes; Michael Gligsberg; Savani Anbalagan; Gil Levkowitz; Rui F. Oliveira. "Oxytocin receptor signaling modulates novelty recognition but not social preference in zebrafish". Journal of Neuroendocrinology (2020): https://doi.org/10.1111%2Fjne.12834.
    10.1111/jne.12834
  8. Kelly J. Robinson; Oliver J. Bosch; Gil Levkowitz; Karl Emanuel Busch; Andrew Jarman; Mike Ludwig. "Social creatures: model animal systems for studying the neuroendocrine mechanisms of social behaviour". Journal of Neuroendocrinology (2019): https://doi.org/10.1111%2Fjne.12807.
    10.1111/jne.12807
  9. Ludmila Gordon; Janna Blechman; Eyal Shimoni; Dvir Gur; Bela Anand-Apte; Gil Levkowitz. "Fenestrae-associated protein Plvap regulates the rate of blood-borne proteins passage into the hypophysis". Development (2019): dev.177790-dev.177790. https://doi.org/10.1242%2Fdev.177790.
    10.1242/dev.177790
  10. Savani Anbalagan; Janna Blechman; Michael Gliksberg; Ludmila Gordon; Ron Rotkopf; Tali Dadosh; Eyal Shimoni; et al. "Robo2 regulates synaptic oxytocin content by affecting actin dynamics". eLife 8 (2019): https://doi.org/10.7554%2Felife.45650.
    10.7554/elife.45650
  11. Polina Denichenko; Maxim Mogilevsky; Antoine Cléry; Thomas Welte; Jakob Biran; Odelia Shimshon; Georgina D. Barnabas; et al. "Specific inhibition of splicing factor activity by decoy RNA oligonucleotides". Nature Communications 10 1 (2019): https://doi.org/10.1038%2Fs41467-019-09523-0.
    10.1038/s41467-019-09523-0
  12. Savani Anbalagan; Ludmila Gordon; Janna Blechman; Ryota L. Matsuoka; Preethi Rajamannar; Einav Wircer; Jakob Biran; et al. "Pituicyte Cues Regulate the Development of Permeable Neuro-Vascular Interfaces". Developmental Cell (2018): https://doi.org/10.1016%2Fj.devcel.2018.10.017.
    10.1016/j.devcel.2018.10.017
  13. Janna Blechman; Savani Anbalagan; Gary G. Matthews; Gil Levkowitz. "Genome Editing Reveals Idiosyncrasy of CNGA2 Ion Channel-Directed Antibody Immunoreactivity Toward Oxytocin". Frontiers in Cell and Developmental Biology 6 (2018): https://doi.org/10.3389%2Ffcell.2018.00117.
    10.3389/fcell.2018.00117
  14. Gur, D.; Nicolas, J.-D.; Brumfeld, V.; Bar-Elli, O.; Oron, D.; Levkowitz, G.. "The Dual Functional Reflecting Iris of the Zebrafish". Advanced Science 5 8 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85051707583&partnerID=MN8TOARS.
    10.1002/advs.201800338
  15. Einav Wircer; Janna Blechman; Nataliya Borodovsky; Michael Tsoory; Ana Rita Nunes; Rui F Oliveira; Gil Levkowitz; et al. "Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior". eLife 6 (2017): https://doi.org/10.7554%2Felife.22170.
    10.7554/elife.22170
  16. Gliksberg, M.; Levkowitz, G.. "Smells Familiar: Pheromone-Induced Neurotransmitter Switching Mediates Social Discrimination". Neuron 95 6 (2017): 1229-1231. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031109052&partnerID=MN8TOARS.
    10.1016/j.neuron.2017.08.044
  17. Blechman, J.; Levkowitz, G.; Gothilf, Y.. "The not-so-long history of zebrafish research in Israel". International Journal of Developmental Biology 61 3-5 (2017): 149-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020310035&partnerID=MN8TOARS.
    10.1387/ijdb.160346gl
  18. Biran, J.; Levkowitz, G.. "Zebrafish Reel in Phenotypic Suppressors of Autism". Neuron 89 4 (2016): 673-675. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958212720&partnerID=MN8TOARS.
    10.1016/j.neuron.2016.02.005
  19. Biran, J.; Tahor, M.; Wircer, E.; Levkowitz, G.. "Role of developmental factors in hypothalamic function". Frontiers in Neuroanatomy 9 APR (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930669411&partnerID=MN8TOARS.
    10.3389/fnana.2015.00047
  20. Blechman, J.; Levkowitz, G.. "Alternative splicing of the pituitary adenylate cyclase-activating polypeptide receptor PAC1: Mechanisms of fine tuning of brain activity". Frontiers in Endocrinology 4 MAY (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884182594&partnerID=MN8TOARS.
    10.3389/fendo.2013.00055
  21. Amir-Zilberstein, L.; Blechman, J.; Sztainberg, Y.; Norton, W.; Reuveny, A.; Borodovsky, N.; Tahor, M.; et al. "Homeodomain Protein Otp and Activity-Dependent Splicing Modulate Neuronal Adaptation to Stress". Neuron 73 2 (2012): 279-291. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856296590&partnerID=MN8TOARS.
    10.1016/j.neuron.2011.11.019
  22. Gutnick, A.; Levkowitz, G.. "The Neurohypophysis: Fishing for New Insights". Journal of Neuroendocrinology 24 6 (2012): 973-974. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860900028&partnerID=MN8TOARS.
    10.1111/j.1365-2826.2012.02292.x
  23. Blechman, J.; Amir-Zilberstein, L.; Gutnick, A.; Ben-Dor, S.; Levkowitz, G.. "The metabolic regulator PGC-1a directly controls the expression of the hypothalamic neuropeptide oxytocin". Journal of Neuroscience 31 42 (2011): 14835-14840. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054757880&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.1798-11.2011
  24. Gutnick, A.; Blechman, J.; Kaslin, J.; Herwig, L.; Belting, H.-G.; Affolter, M.; Bonkowsky, J.; Levkowitz, G.. "The Hypothalamic Neuropeptide Oxytocin Is Required for Formation of the Neurovascular Interface of the Pituitary". Developmental Cell 21 4 (2011): 642-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054736169&partnerID=MN8TOARS.
    10.1016/j.devcel.2011.09.004
  25. Machluf, Y.; Levkowitz, G.. "Visualization of mRNA expression in the zebrafish embryo.". Methods in molecular biology (Clifton, N.J.) 714 (2011): 83-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960073267&partnerID=MN8TOARS.
    10.1007/978-1-61779-005-8_6
  26. Palevitch, O.; Abraham, E.; Borodovsky, N.; Levkowitz, G.; Zohar, Y.; Gothilf, Y.. "Cxcl12a-Cxcr4b signaling is important for proper development of the forebrain GnRH system in zebrafish". General and Comparative Endocrinology 165 2 (2010): 262-268. http://www.scopus.com/inward/record.url?eid=2-s2.0-71549145276&partnerID=MN8TOARS.
    10.1016/j.ygcen.2009.07.001
  27. Russek-Blum, N.; Nabel-Rosen, H.; Levkowitz, G.. "Two-photon-based photoactivation in live zebrafish embryos". Journal of Visualized Experiments 46 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-80355125608&partnerID=MN8TOARS.
    10.3791/1902
  28. Russek-Blum, N.; Nabel-Rosen, H.; Levkowitz, G.. "High resolution fate map of the zebrafish diencephalon". Developmental Dynamics 238 7 (2009): 1827-1835. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649579855&partnerID=MN8TOARS.
    10.1002/dvdy.21987
  29. Palevitch, O.; Abraham, E.; Borodovsky, N.; Levkowitz, G.; Zohar, Y.; Gothilf, Y.. "Nasal embryonic LHRH factor plays a role in the developmental migration and projection of gonadotropin-releasing hormone 3 neurons in zebrafish". Developmental Dynamics 238 1 (2009): 66-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149242345&partnerID=MN8TOARS.
    10.1002/dvdy.21823
  30. Borodovsky, N.; Ponomaryov, T.; Frenkel, S.; Levkowitz, G.. "Neural protein olig2 acts upstream of the transcriptional regulator sim1 to specify diencephalic dopaminergic neurons". Developmental Dynamics 238 4 (2009): 826-834. http://www.scopus.com/inward/record.url?eid=2-s2.0-63849087590&partnerID=MN8TOARS.
    10.1002/dvdy.21894
  31. Russek-Blum, N.; Gutnick, A.; Nabel-Rosen, H.; Blechman, J.; Staudt, N.; Dorsky, R.I.; Houart, C.; Levkowitz, G.. "Dopaminergic neuronal cluster size is determined during early forebrain patterning". Development 135 20 (2008): 3401-3413. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149214747&partnerID=MN8TOARS.
    10.1242/dev.024232
  32. Blechman, J.; Borodovsky, N.; Eisenberg, M.; Nabel-Rosen, H.; Grimm, J.; Levkowitz, G.. "Specification of hypothalamic neurons by dual regulation of the homeodomain protein Orthopedia". Development 134 24 (2007): 4417-4426. http://www.scopus.com/inward/record.url?eid=2-s2.0-38349026620&partnerID=MN8TOARS.
    10.1242/dev.011262
  33. Wilcock, D.M.; Rojiani, A.; Rosenthal, A.; Levkowitz, G.; Subbarao, S.; Alamed, J.; Wilson, D.; et al. "Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition". Journal of Neuroscience 24 27 (2004): 6144-6151. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042839092&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.1090-04.2004
  34. Levkowitz, G.; Zeller, J.; Sirotkin, H.I.; French, D.; Schilbach, S.; Hashimoto, H.; Hibi, M.; Talbot, W.S.; Rosenthal, A.. "Zinc finger protein too few controls the development of monoaminergic neurons". Nature Neuroscience 6 1 (2003): 28-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037223399&partnerID=MN8TOARS.
    10.1038/nn979
  35. Levkowitz, G.; Oved, S.; Klapper, L.N.; Harari, D.; Lavi, S.; Sela, M.; Yarden, Y.; et al. "c-Cbl is a suppressor of the Neu oncogene". Journal of Biological Chemistry 275 45 (2000): 35532-35539. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034634678&partnerID=MN8TOARS.
    10.1074/jbc.M002661200
  36. Levkowitz, G.; Waterman, H.; Ettenberg, S.A.; Katz, M.; Tsygankov, A.Y.; Alroy, I.; Lavi, S.; et al. "Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1". Molecular Cell 4 6 (1999): 1029-1040. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033392493&partnerID=MN8TOARS.
  37. Waterman, H.; Levkowitz, G.; Alroy, I.; Yarden, Y.. "The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor". Journal of Biological Chemistry 274 32 (1999): 22151-22154. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033529537&partnerID=MN8TOARS.
    10.1074/jbc.274.32.22151
  38. Levkowitz, G.; Waterman, H.; Zamir, E.; Kam, Z.; Oved, S.; Langdon, W.Y.; Beguinot, L.; Geiger, B.; Yarden, Y.. "c-Cb1/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor". Genes and Development 12 23 (1998): 3663-3674. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032217156&partnerID=MN8TOARS.
  39. Tzahar, E.; Moyer, J.D.; Waterman, H.; Barbacci, E.G.; Bao, J.; Levkowitz, G.; Shelly, M.; et al. "Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network". EMBO Journal 17 20 (1998): 5948-5963. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032531927&partnerID=MN8TOARS.
    10.1093/emboj/17.20.5948
  40. Tzahar, E.; Pinkas-Kramarski, R.; Moyer, J.D.; Klapper, L.N.; Alroy, I.; Levkowitz, G.; Shelly, M.; et al. "Bivalence of EGF-like ligands drives the ErbB signaling network". EMBO Journal 16 16 (1997): 4938-4950. http://www.scopus.com/inward/record.url?eid=2-s2.0-20244367576&partnerID=MN8TOARS.
    10.1093/emboj/16.16.4938
  41. Pinkas-Kramarski, R.; Eilam, R.; Alroy, I.; Levkowitz, G.; Lonai, P.; Yarden, Y.. "Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation". Oncogene 15 23 (1997): 2803-2815. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031465112&partnerID=MN8TOARS.
  42. Levkowitz, G.; Klapper, L.N.; Tzahar, E.; Freywald, A.; Sela, M.; Yarden, Y.. "Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins". Oncogene 12 5 (1996): 1117-1125. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029917264&partnerID=MN8TOARS.
  43. Pinkas-Kramarski, R.; Soussan, L.; Waterman, H.; Levkowitz, G.; Alroy, I.; Klapper, L.; Lavi, S.; et al. "Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions". EMBO Journal 15 10 (1996): 2452-2467. http://www.scopus.com/inward/record.url?eid=2-s2.0-2142843806&partnerID=MN8TOARS.
  44. Tzahar, E.; Waterman, H.; Chen, X.; Levkowitz, G.; Karunagaran, D.; Lavi, S.; Ratzkin, B.J.; Yarden, Y.. "A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor". Molecular and Cellular Biology 16 10 (1996): 5276-5287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029814271&partnerID=MN8TOARS.
  45. Chen, X.; Levkowitz, G.; Tzahar, E.; Karunagaran, D.; Lavi, S.; Ben-Baruch, N.; Leitner, O.; et al. "An immunological approach reveals biological differences between the two NDF/heregulin receptors, ErbB-3 and ErbB-4". Journal of Biological Chemistry 271 13 (1996): 7620-7629. http://www.scopus.com/inward/record.url?eid=2-s2.0-13344284648&partnerID=MN8TOARS.
    10.1074/jbc.271.13.7620
  46. Dong, Z.; Brennan, A.; Liu, N.; Yarden, Y.; Lefkowitz, G.; Mirsky, R.; Jessen, K.R.; Levkowitz, Gil. "Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors". Neuron 15 3 (1995): 585-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029146540&partnerID=MN8TOARS.
    10.1016/0896-6273(95)90147-7
  47. Berko-Flint, Y.; Levkowitz, G.; Vardimon, L.. "Involvement of c-Jun in the control of glucocorticoid receptor transcriptional activity during development of chicken retinal tissue". EMBO Journal 13 3 (1994): 646-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028157769&partnerID=MN8TOARS.
  48. Tzahari, E.; Levkowitz, G.; Karunagaran, D.; Yi, L.; Peles, E.; Lavi, S.; Chang, D.; et al. "ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms". Journal of Biological Chemistry 269 40 (1994): 25226-25233. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027971393&partnerID=MN8TOARS.
Capítulo de livro
  1. Levkowitz, Gil. "Development and Function of the Zebrafish Neuroendocrine System". 2018.
    10.1002/9781119391128.ch5
  2. Levkowitz, Gil; Einav Wircer; Shifra Ben-Dor; Gil Levkowitz. "Non-mammalian models for neurohypophysial peptides". 2016.
    DOI: 10.1002/9781118760369.ch14
Edição de livro
  1. Levkowitz, Gil. Model Animals in Neuroendocrinology: From Worm to Mouse to Man. 2018.
    10.1002/9781119391128
Livro
  1. Book Editor, Model Animals in Neuroendocrinology (ed. M. Ludwig & G. Levkowitz). An open-ended series of books “Masterclass in Neuroendocrinology Series”, a joint venture between the International Neuroendocrine Federation (http://neuroendonow.com) and Wiley-Blackwell. Book was written by experts for students, trainees, established researchers, and teachers.. 2018.
    Editor
  2. Machluf, Y.; Gutnick, A.; Levkowitz, G.. Development of the zebrafish hypothalamus. 2011.
    10.1111/j.1749-6632.2010.05945.x

Propriedade Intelectual

Patente
  1. GIL LEVKOWITZ. 2005. "METHODS OF TREATING ALZHEIMER'S DISEASE USING ANTIBODIES DIRECTED AGAINST AMYLOID BETA PEPTIDE AND COMPOSITIONS THEREOF.".

Outros

Outra produção
  1. The Neurohypophysis and Urophysis: Ancient Piscine Neurovascular Interfaces. 2022. Preethi Rajamannar; Iswarya Arokiadhas; Gil Levkowitz; Jakob Biran. https://doi.org/10.1007%2F978-3-030-86630-3_4.
    10.1007/978-3-030-86630-3_4
  2. Stress resilience is established during development and is regulated by complement factors. 2022.
    https://doi.org/10.1101/2022.01.31.478444
  3. Oxytocin signaling regulates the homeostatic response to cold stress in poikilothermic vertebrates.. 2022.
  4. Oxytocin regulation of social transmission of fear in zebrafish reveals its evolutionary conserved role in emotional contagion. 2021.
    https://doi.org/10.1101/2021.10.06.463413
  5. Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior. 2020. Levkowitz, Gil. https://doi.org/10.1101%2F2020.01.24.918185.
    10.1101/2020.01.24.918185
  6. ErbB. 2002. Gil Levkowitz; Yosef Yarden.
    10.1002/0471203076.emm0787
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022 Sexual dimorphism of neuronal circuits and behavior.
Weizmann Institute, Israel.
2021 Keynote Lecture on Regulatory Peptides : 23rd International Symposium on Regulatory Peptides (RegPep2020). Acapulco Diamante, Mexico.
2021 Cold Spring Harbor Meeting on the “Brain Barriers” (formerly known as the “Blood-Brain Barrier”). Cold Spring Harbor Laboratory, NY, USA. (virtual)
2021 Developing Neural Circuits Course 2020. Okinawa Institute of Science and Technology. Okinawa, Japan. (virtual)
2020 9th Congress of the Federation of the Israel Societies for Experimental Biology (FISEB). Eilat, Israel.
2019 Annual conference of the Israel Endocrine Society (IES). Kfar Blum, Israel.
2019 Symposium: From single cell to single molecule imaging in endocrine systems. University of Edinburgh, Edinburgh UK
2019 14th International Zebrafish Conference - Suzhou, China.
2019 German-Israel-MINERVA School “Bridging the gap between genes and behavior: Neuropeptide regulation of socio-emotional behaviors”. Regensburg, Germany.
2019 2nd Munich Winter Conference on Stress. Garmisch-Partenkirchen, Germany.
2018 12th Pituitary and Hypothalamus meeting, Tepoztalan, Mexico.
2018 18th European Neuroendocrine Association (ENEA) conference. Wroclaw, Poland.
2018 State-of-the-Art speaker: European Society for Comparative Endocrinology (ESCE). Glasgow, UK.
2018 State-of-the-Art speaker: 9th International Congress of Neuroendocrinology (ICN 2018) - International Neuroendocrine Federation, Toronto, Canada.
2018 5th European Zebrafish Principal Investigators Meeting (EZPM). Trento, Italy.
2017 Distinguished guest speaker: Lifecourse Biology Symposium: From development to disease and the clinic. Sheffield, UK.
2017 The MBL Zebrafish Genetics and Development Course – A special 20th anniversary symposium marking 20 successful years training the next generation. Woods Hole, USA.
2017 Behaviour 2017, a joint meeting of the 35th International Ethological Conference (IEC) and the 2017 Summer Meeting of the Association for the Study of Animal Behaviour (ASAB). Estoril, Portugal.
2017 Plenary Speaker: 12th World Congress on Neurohypophysial Hormones, Mangaratiba, Rio de Janeiro, Brazil.
2017 Joint Weizmann-SISSA (The International School for Advanced Studies) conference for statistical physics and brain research. Weizmann Institute, Rehovot, Israel.
2017 8th Congress of the Federation of the Israel Societies for Experimental Biology (FISEB). Eilat, Israel.
2016 10th Pituitary and Hypothalamus meeting, Lauret. France.
2016 Michigan-Israel Partnership for Research and Education Symposium. Ann Arbor, MI, USA.
2016 Annual meeting of the Israel Society of Physiology and Pharmacology (ISPP). Tel Aviv, Israel.
2016 4th European Zebrafish Principal Investigators Meeting (EZPM). Lisbon, Portugal
2015 Assembly and Disassembly of the Nervous System. A Student-Organized International Conference. Weizmann Institute, Rehovot, Israel
2014 8th Pituitary Meeting, University of Edinburgh, Edinburgh, Scotland, UK.
2014 24th Pasteur-Weizmann Symposium. Biological Communication. Institut Pasteur, Paris, France.
2014 9th Federation of European Neuroscience Society (FENS) Forum, Milan, Italy.
2014 3rd European Zebrafish Principal Investigators Meeting (EZPM). Ein-Gedi, Israel.
2014 7th Congress of the Federation of the Israel Societies for Experimental Biology (FISEB). Eilat, Israel.
2014 The Life Sciences Faculties Lecture. Weizmann Institute of Science, Rehovot, Israel.
2013 45th European Brain and Behaviour Society, Munich, Germany.
2013 The Israeli Society for Developmental Biology, Cesaria, Israel
2011 10th International Symposium on VIP, PACAP and Related Peptides. Eilat, Israel.
2011 6th Congress of the Federation of the Israel Societies for Experimental Biology (FISEB). Eilat, Israel.
2010 Department of Neurobiology, Harvard Medical School, Boston, MA, USA
2010 State-of-the-Art speaker: International Congress of Neuroendocrinology (International Neuroendocrine Federation), Rouen, France.
2010 22nd Pasteur-Weizmann Symposium - Stems Cells - From Basic Biology to Clinical Therapies. Rome, Italy.
2009 European Neuropeptide Club and the US Summer Neuropeptide Conference. Salzburg, Austria.
2009 Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
2008 3rd Strategic Conference of Zebrafish Investigators. Asilomar, Pacific Grove, CA, USA
2008 Albert-Ludwigs-Universität Freiburg Seminar series: “From cells to organs: Molecular mechanisms of Organogenesis”. University of Freiburg, Freiburg, Germany.
2008 9th international Nerve Growth Factor meeting (NGF 2008). Kfar Blum, Israel.
2008 Gordon Research Conference on Neural Development (Hot topics), Salve Regina University, USA.
2008 17th Biennial Meeting of the International Society for Development Neuroscience. Asilomar, Pacific Grove, CA, USA.
2008 Minna-James-Heineman International Symposium: Multidisciplinary challenges in biology: From Cell Cycle Control to Embryo Organogenesis. Weizmann Institute, Israel.

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2012 - 2014 Studying Anxiety Behavior In Zebrafish Larvae Using Genetic Perturbation Of The Hypothalamo-Pituitary-Adrenal (HPA) Axis
Orientador de Eva Mishor
Weizmann Institute of Science, Israel
2012 - 2014 Studying the dynamics of the oxytocinergic system and its effect on behavior using the larval zebrafish model system
Orientador de Michael Gliksberg
Weizmann Institute of Science, Israel
2008 - 2012 The role of axona-vascular interactions in the morphogenesis of the neurohypophysis
Orientador de Amos Gutnick
Weizmann Institute of Science, Israel
2007 - 2012 Regulation of hypothalamic development by the transcription factor Sim1
Orientador de Nataliya Borodovsky
Weizmann Institute of Science, Israel
2004 - 2009 Identification of novel determinants of dopaminergic and isotocinergic neural fates: Lhx5 and Wnt-antagonists act downstream of the conserved transcriptional regulator Fezf2
Orientador de Yossy Machluf
Weizmann Institute of Science, Israel
2004 - 2009 Deciphering Developmental Processes that Determine the Size of Dopaminergic Neuronal Population in the Zebrafish Brain
Orientador de Niva Russek-Blum
Weizmann Institute of Science, Israel
2007 - 2008 Dopaminergic neurons specification requires the sequential activity of pan-neuronal and type-specific transcription factors
Orientador de Shani Frenkel
Weizmann Institute of Science, Israel
2006 - 2007 Genetic cascade underlying cell fate decision in the zebrafish hypothalamus
Orientador de Maya Lavid
Weizmann Institute of Science, Israel
2005 - 2006 Genetic cascade underlying cell fate decisions in the zebrafish hypothalamus
Orientador de Nataliya Borodovsky
Weizmann Institute of Science, Israel
2004 - 2005 In vivo Labeling of Zebrafish Neurons as a Prospective Tool for Realtime Analysis of Dopaminergic Neural Development
Orientador de Hila Sberro
Weizmann Institute of Science, Israel
2004 - 2005 The role of Wnt pathway antagonists (e.g. Dkk1 and Wif1) in regulating the number of dopaminergic progenitors
Orientador de Amos Gutnick
Weizmann Institute of Science, Israel

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022 - Atual Programme Organizing Committee: 10th International Congress of Neuroendocrinology (ICN 2022) - International Neuroendocrine Federation, Glasgow, UK. (2022)
2020 - Atual International Organizing Committee, 14th World Congress on Neurohypophysial Hormones (WCNH), Atlanta, USA. (2022)
2013 - Atual Organizing Committee, 10th World Congress on Neurohypophysial Hormones Bristol, UK. (2013)
2020 - 2020 Advisory Committee (Neuroscience and Endocrinology): The 9th Congress of the Federation of the Israel Societies for Experimental Biology (FISEB). Eilat, Israel. (2020 - 2020)
Congresso (Outra)
2020 - 2020 International Scientific Committee: The 23rd International Symposium on Regulatory Peptides: RegPep2020 of the International Regulatory Peptide Society (IRPS). Acapulco, Mexico (2020 - 2020)
Congresso (Membro da Comissão Científica)
2019 - 2019 Main co-Organizer: 13th World Congress on Neurohypophysial Hormones (WCNH), Ein Gedi, Israel (2019 - 2019)
Congresso (Coorganizador)
2017 - 2017 Symposium organizer: ‘Effects of oxytocin on social behavior in fish and mammals’. Behaviour 2017, a joint meeting of the 35th International Ethological Conference (IEC) and the 2017 Summer Meeting of the Association for the Study of Animal Behaviour (ASAB). Estoril, Portugal. (2017 - 2017)
Encontro (Outra)
2017 - 2017 International Organizing Committee, 12th World Congress on Neurohypophysial Hormones (WCNH), Mangaratiba, RJ, Brazil. (2017 - 2017)
Congresso (Membro da Comissão Organizadora)
2016 - 2016 Scientific Advisor, Student-Organized International Conference on Hormones and Behavior. Weizmann Institute, Rehovot, Israel (2016 - 2016)
Conferência (Membro da Comissão Científica)
 Weizmann Institute of Science, Israel
2015 - 2015 International Organizing Committee, 11th World Congress on Neurohypophysial Hormones (WCNH), Queenstown, New Zealand. (2015 - 2015)
Congresso (Membro da Comissão Organizadora)
2013 - 2013 International Organizing Committee, 10th World Congress on Neurohypophysial Hormones (WCNH), Bristol, United Kingdom. (2013 - 2013)
Congresso (Membro da Comissão Organizadora)
2011 - 2011 Organizing committee, Measuring Behavior and Physiology: Bridging the Genotype Phenotype Gap, Weizmann Institute of Science, Rehovot, Israel (2011 - 2011)
Congresso (Membro da Comissão Organizadora)
 Weizmann Institute of Science, Israel
2011 - 2011 Symposium organizer: ‘Genetic Models for Neurohypophyseal Development and Function’. 9th World Congress on Neurohypophysial Hormones (WCNH 2011). Northeastern University, Boston, MA, USA (2011 - 2011)
Congresso (Coorganizador)
2011 - 2011 Organizing committee, 10th International Symposium on VIP, PACAP and Related Peptides. Eilat, Israel (2011 - 2011)
Simpósio (Membro da Comissão Organizadora)
2010 - 2010 Main co-organizer: The 2nd Israeli Meeting on Zebrafish as a Model Organism for Biomedical Studies. Tel Aviv, Israel (2010 - 2010)
Congresso (Coorganizador)
2009 - 2009 Scientific program advisory committee, 6th European Zebrafish Development and Genetics Meeting, Rome, Italy (2009 - 2009)
Congresso (Membro da Comissão Científica)
2008 - 2008 Main co-organizer: Zebrafish as a Model Organism: New horizon for basic and applied research. (2008 - 2008)
Conferência (Coorganizador)
 Tel Aviv University, Israel
2008 - 2008 Main co-organizer: Minna-James-Heineman international mini symposium: “Multidisciplinary challenges in biology: From Cell Cycle Control to Embryo Organogenesis” (2008 - 2008)
Simpósio (Coorganizador)
 Weizmann Institute of Science, Israel

Arbitragem científica em conferência

Nome da conferência Local da conferência
2022 - Atual The 23rd International Symposium on Regulatory Peptides RegPep2020 of the International Regulatory Peptide Society (IRPS). Acapulco, Mexico.

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019 - Atual Journal of Neuroendocrinology / Guest Senior Editor. Special Issue of the 13th World Congress of Neurohypophysial Hormones 2019.
2019 - Atual eLife

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2012 - 2015 Member, Theses Committee of the Weizmann’s Scientific Council
2007 - 2008 Faculty of Biology Senior Scientists representative to the Scientific Council.

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021 - Atual Developing Neural Circuits Course 2020. Okinawa Institute of Science and Technology. Okinawa, Japan.
2019 - Atual Nanocourse on Neuroendocrinology, Gulbenkian Institute of Science, Oeiras, Portugal.
2019 - Atual Neurobiology: brain and behaviour course. PhD Programme in Integrative Biology and Biomedicine. Gulbenkian Institute of Science, Oeiras, Portugal.
2005 - Atual Coordinator, DeShalit Workshop for B.Sc. students of the Life Sciences, Weizmann Institute.
1998 - Atual Instructor in the EMBO practical course on Signal Transduction by Polypeptide Growth Factors. Weizmann Institute.
2007 - 2011 Head, Weizmann Institute’s Undergraduate Summer Program, Kupcient-Getz Summer School for International and Israeli Students, Weizmann Institute.
2005 - 2011 Developmental Neurobiology Course, Weizmann Institute.
2005 - 2007 Seminar course on Molecular Neurobiology: From Development to Function, Weizmann Institute.
1994 - 1996 Mentor in the 26th, 27th and 28th Dr. Bessie F. Lawrence International Summer Science Institute, Youth Activities Section, Weizmann Institute.
1991 - 1993 Biochemistry laboratory instructor, Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.

Membro de associação

Nome da associação Tipo de participação
2021 - Atual Governing Council Member - International Regulatory Peptide Society (IRPS).

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019 - Atual Member of the Weizmann ¿Institutional Animal Care and Use Committee (IACUC)¿.¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿
2016 - Atual Executive board member, European network on Fish Biomedical Models (EuFishBioMed).
2013 - Atual Ad hoc Chairman, Users Committee of the Bioinformatics Unit of the Israel National Center for Personalized Medicine (INCP).
2013 - Atual Advisory Committee Member, Aharon Katzir-Katchalsky Center of the Weizmann Institute.
2018 - 2021 Member of the Weizmann’s Scientific Council Senior Scientists Appointments and Promotion Committee (V9).
2015 - 2021 Member of the Weizmann’s Life Sciences Faculties Postdoctoral Training Program Committee.
2014 - 2020 Member of the Weizmann’s Life Sciences Board of Studies of the Feinberg Graduate School.
2016 - 2019 Member of the Weizmann’s Scientific Council Staff Scientists Appointment and Promotions Committee.
2015 - 2018 Member of the Life Sciences Faculties Staff Scientist Appointment and Promotions Committee, Weizmann Institute.
2012 - 2015 Member of the Weizmann ¿Institutional Animal Care and Use Committee (IACUC)¿.¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿
2009 - 2015 European network on Fish Biomedical Models (EuFishBioMed), COST action member country representative.
Distinções

Prémio

2009 The Teva Pharmaceutical Research Award in Biotechnology for outstanding young scientist
Teva Pharmaceuticals USA Inc, Estados Unidos
2008 Program committee award at the 17th Biennial Meeting of the International Society for Development Neuroscience (ISDN)
International Society for Development Neuroscience, Estados Unidos
2005 The Richard Heikilla award for young researcher
National Parkinson Foundation, Estados Unidos
1999 John F. Kennedy prize for excellence in PhD studies
Weizmann Institute of Science, Israel

Título

2013 Incumbent of the Elias Sourasky Professorial Chair
Weizmann Institute of Science, Israel
2004 The Tauro Career Development Chair in biomedical research
Weizmann Institute of Science, Israel
2000 Long-term postdoctoral fellowship
European Molecular Biology Laboratory Hamburg, Alemanha

Outra distinção

2001 Long-term postdoctoral fellowship (declined)
Human Frontier Science Program, França
1997 A fellowship of distinction for outstanding achievement in research
Weizmann Institute of Science, Israel
1994 Lillian Hilman Kugler scholarship in cancer research
Weizmann Institute of Science, Israel
1993 Scholarship for academic achievements
Tel Aviv University, Israel